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Investigate potential for using shared mutations for clustering #175

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matsen opened this issue Mar 23, 2016 · 2 comments
Open

Investigate potential for using shared mutations for clustering #175

matsen opened this issue Mar 23, 2016 · 2 comments

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@matsen
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matsen commented Mar 23, 2016

This paper finds that B cell phylogenies look like this:

screenshot 2016-03-23 at 6 56 11 am

This could be very helpful for BCR clustering, because we could use shared mutations to distinguish between lineages.

In a collection of the biggish clusters on real data, do we see this too?

This could be evaluated by either building trees or by looking at shared mutations in germline encoded regions.

@psathyrella
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Very similar to #29

@matsen
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matsen commented Apr 6, 2016

Make this a second phase?

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