diff --git a/.github/workflows/build_daily.yaml b/.github/workflows/build_daily.yaml
index 1c7e9459687..fe64c21dfe2 100644
--- a/.github/workflows/build_daily.yaml
+++ b/.github/workflows/build_daily.yaml
@@ -152,3 +152,38 @@ jobs:
           steps: ${{ toJson(steps) }}
           channel: '#contour-ci-notifications'
         if: ${{ failure() && github.ref == 'refs/heads/main' }}
+  e2e-endpoint-slices:
+    runs-on: ubuntu-latest
+    steps:
+      - uses: actions/checkout@v3
+      - uses: actions/cache@v3
+        with:
+          # * Module download cache
+          # * Build cache (Linux)
+          path: |
+            ~/go/pkg/mod
+            ~/.cache/go-build
+          key: ${{ runner.os }}-${{ github.job }}-go-${{ hashFiles('**/go.sum') }}
+          restore-keys: |
+            ${{ runner.os }}-${{ github.job }}-go-
+      - uses: actions/setup-go@v4
+        with:
+          go-version: ${{ env.GO_VERSION }}
+          cache: false
+      - name: add deps to path
+        run: |
+          ./hack/actions/install-kubernetes-toolchain.sh $GITHUB_WORKSPACE/bin
+          echo "$GITHUB_WORKSPACE/bin" >> $GITHUB_PATH
+      - name: e2e tests
+        env:
+          CONTOUR_E2E_IMAGE: ghcr.io/projectcontour/contour:main
+          CONTOUR_E2E_USE_ENDPOINT_SLICES: true
+        run: |
+          make setup-kind-cluster run-e2e cleanup-kind
+      - uses: act10ns/slack@v2
+        with:
+          status: ${{ job.status }}
+          steps: ${{ toJson(steps) }}
+          channel: '#contour-ci-notifications'
+        if: ${{ failure() && github.ref == 'refs/heads/main' }}
+
diff --git a/internal/xdscache/v3/endpointslicetranslator_test.go b/internal/xdscache/v3/endpointslicetranslator_test.go
index 6a75ce36716..198c3620186 100644
--- a/internal/xdscache/v3/endpointslicetranslator_test.go
+++ b/internal/xdscache/v3/endpointslicetranslator_test.go
@@ -665,11 +665,6 @@ func TestEndpointSliceTranslatorRemoveEndpoints(t *testing.T) {
 			observer := &simpleObserver{}
 			endpointSliceTranslator.Observer = observer
 
-			// TODO(jpeach): this doesn't actually test
-			// that deleting endpoints works. We ought to
-			// ensure the cache is populated first and
-			// only after that, verify that deletion gives
-			// the expected result.
 			endpointSliceTranslator.OnDelete(tc.endpointSlice)
 			got := endpointSliceTranslator.Contents()
 			protobuf.ExpectEqual(t, tc.want, got)
diff --git a/test/e2e/fixtures.go b/test/e2e/fixtures.go
index 2e584b9e660..95762b1d2cc 100644
--- a/test/e2e/fixtures.go
+++ b/test/e2e/fixtures.go
@@ -19,6 +19,7 @@ import (
 	"context"
 	"io"
 	"os"
+	"strconv"
 
 	"github.com/onsi/ginkgo/v2"
 	contour_api_v1alpha1 "github.com/projectcontour/contour/apis/projectcontour/v1alpha1"
@@ -566,6 +567,7 @@ func DefaultContourConfiguration() *contour_api_v1alpha1.ContourConfiguration {
 				Address: listenAllAddress(),
 				Port:    8000,
 			},
+			UseEndpointSlice: UseEndpointSlicesFromEnv(),
 			Envoy: &contour_api_v1alpha1.EnvoyConfig{
 				DefaultHTTPVersions: []contour_api_v1alpha1.HTTPVersionType{
 					"HTTP/1.1", "HTTP/2",
@@ -638,6 +640,17 @@ func XDSServerTypeFromEnv() contour_api_v1alpha1.XDSServerType {
 	return serverType
 }
 
+func UseEndpointSlicesFromEnv() bool {
+	useFromEnv, found := os.LookupEnv("CONTOUR_E2E_USE_ENDPOINT_SLICES")
+	if found {
+		useEndpointSlices, err := strconv.ParseBool(useFromEnv)
+		if err == nil {
+			return useEndpointSlices
+		}
+	}
+	return false
+}
+
 func valOrDefault(val, defaultVal string) string {
 	if val != "" {
 		return val
diff --git a/test/e2e/infra/endpointslice_test.go b/test/e2e/infra/endpointslice_test.go
index eeec2fb8035..576c8043831 100644
--- a/test/e2e/infra/endpointslice_test.go
+++ b/test/e2e/infra/endpointslice_test.go
@@ -60,7 +60,7 @@ func testSimpleEndpointSlice(namespace string) {
 		}
 
 		f.CreateHTTPProxyAndWaitFor(p, e2e.HTTPProxyValid)
-		time.Sleep(time.Second * 120)
+		time.Sleep(time.Second * 5)
 
 		k8sPodIPs, err := f.Fixtures.Echo.ListPodIPs(namespace, "echo")
 		require.NoError(f.T(), err)