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Copy pathCICR_Li-Rinzel1994.cps
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CICR_Li-Rinzel1994.cps
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<body xmlns="http://www.w3.org/1999/xhtml"><h1>Li-Rinzel model of calcium oscillations</h1>
<p>This is a core model of calcium-induded calcium release developed by <a href="https://doi.org/10.1006/jtbi.1994.1041">Li and Rinzel</a>, a reduced version of an earlier mechanistic model by <a href="https://doi.org/10.1073/pnas.89.20.9895">De Young and Keizer</a>. The reduction, based on time scale separation, follows a formalism similar to that used by Hodgkin and Huxley to develop a model of excitability of the neuronal plasma membrane.</p>
<p style="font-size:small"><b>CC0 1.0 Universal</b>: To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Creative Commons CC0">CC0 Public Domain Dedication</a> for more information.</p></body>
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<ModelParameter cn="CN=Root,Model=CICR model by Li and Rinzel,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=h" value="2" type="ReactionParameter" simulationType="fixed"/>
<ModelParameter cn="CN=Root,Model=CICR model by Li and Rinzel,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=Shalve" value="0.10000000000000001" type="ReactionParameter" simulationType="assignment">
<InitialExpression>
<CN=Root,Model=CICR model by Li and Rinzel,Vector=Values[k_pl],Reference=InitialValue>
</InitialExpression>
</ModelParameter>
<ModelParameter cn="CN=Root,Model=CICR model by Li and Rinzel,Vector=Reactions[R4],ParameterGroup=Parameters,Parameter=V" value="0.018000000000000002" type="ReactionParameter" simulationType="assignment">
<InitialExpression>
<CN=Root,Model=CICR model by Li and Rinzel,Vector=Values[e_v4],Reference=InitialValue>
</InitialExpression>
</ModelParameter>
</ModelParameterGroup>
</ModelParameterGroup>
</ModelParameterSet>
</ListOfModelParameterSets>
<StateTemplate>
<StateTemplateVariable objectReference="Model_0"/>
<StateTemplateVariable objectReference="ModelValue_10"/>
<StateTemplateVariable objectReference="ModelValue_6"/>
<StateTemplateVariable objectReference="Metabolite_2"/>
<StateTemplateVariable objectReference="Metabolite_0"/>
<StateTemplateVariable objectReference="ModelValue_1"/>
<StateTemplateVariable objectReference="ModelValue_0"/>
<StateTemplateVariable objectReference="Metabolite_1"/>
<StateTemplateVariable objectReference="Compartment_1"/>
<StateTemplateVariable objectReference="Compartment_0"/>
<StateTemplateVariable objectReference="ModelValue_17"/>
<StateTemplateVariable objectReference="ModelValue_16"/>
<StateTemplateVariable objectReference="ModelValue_15"/>
<StateTemplateVariable objectReference="ModelValue_14"/>
<StateTemplateVariable objectReference="ModelValue_13"/>
<StateTemplateVariable objectReference="ModelValue_12"/>
<StateTemplateVariable objectReference="ModelValue_11"/>
<StateTemplateVariable objectReference="ModelValue_9"/>
<StateTemplateVariable objectReference="ModelValue_8"/>
<StateTemplateVariable objectReference="ModelValue_7"/>
<StateTemplateVariable objectReference="ModelValue_5"/>
<StateTemplateVariable objectReference="ModelValue_4"/>
<StateTemplateVariable objectReference="ModelValue_3"/>
<StateTemplateVariable objectReference="ModelValue_2"/>
</StateTemplate>
<InitialState type="initialState">
0 2 0.80000000000000004 1.204428152e+17 5.8593801989189192e+18 0.012 0.018000000000000002 3.613284456e+17 1 0.185 0.02 0.59999999999999998 0.17999999999999999 40 0.13 0.40000000000000002 0.20000000000000001 0.40000000000000002 0.185 1 1.8 1.2 0.10000000000000001 0.01
</InitialState>
</Model>