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Package for Automated Non-Compartmental Analysis" +author: + - name: Ercan Suekuer, Jana Spinner, Gerardo R +description: "(A Roche x Appsilon x Human Predictions Collaboration)" +# Note that the date below will be auto-updated when the post is merged. +date: "2024-11-20" +# Please do not use any non-default categories. +# You can find the default categories in the repository README.md +categories: [Shiny, ADaM, TLG, Submissions] +# Feel free to change the image +image: "aNCA_logo.png" +--- + + + +```{r setup, include=FALSE} +long_slug <- "zzz_DO_NOT_EDIT_a_nca" +# renv::use(lockfile = "renv.lock") +``` + + + + + +### What is [aNCA](https://github.com/pharmaverse/aNCA)? + +The [aNCA](https://github.com/pharmaverse/aNCA) package is an open source tool developed in collaboration between Roche, Appsilon, and Human Predictions. This new addition to the [pharmaverse](https://pharmaverse.org/) is designed to simplify Non-Compartmental Analysis (NCA), making it more accessible for all scientists across industries. + +### **The aNCA package empowers users to:** + +- Perform NCA on both non-clinical and clinical data +- Automatically calculate PK parameters for various dosing regimens +- Conduct manual selections and exclusions for lambda-z regression +- Visualize results dynamically with editable plots and summary tables +- Export PK parameters into a comprehensive, ready-to-use reports + +This tool is built using `shiny` with user-friendliness in mind, allowing both novice and experienced users to seamlessly integrate it into their workflows. + + + +### **Get Started!** + +To try out the package, head to the [GitHub](https://github.com/pharmaverse/aNCA) repository and follow the installation steps. There you can also find how to contribute or share feedback with us (don't forget to star the project if you like it!). Let’s keep pushing the boundaries of open-source tools! + + + +```{r, echo=FALSE} +source("appendix.R") +insert_appendix( + repo_spec = "pharmaverse/blog", + name = long_slug, + # file_name should be the name of your file + file_name = list.files() %>% stringr::str_subset(".qmd") %>% first() +) +``` diff --git a/posts/zzz_DO_NOT_EDIT_a_nca/appendix.R b/posts/zzz_DO_NOT_EDIT_a_nca/appendix.R new file mode 100644 index 00000000..1438595d --- /dev/null +++ b/posts/zzz_DO_NOT_EDIT_a_nca/appendix.R @@ -0,0 +1,73 @@ +suppressMessages(library(dplyr)) +# markdown helpers -------------------------------------------------------- + +markdown_appendix <- function(name, content) { + paste(paste("##", name, "{.appendix}"), " ", content, sep = "\n") +} +markdown_link <- function(text, path) { + paste0("[", text, "](", path, ")") +} + + + +# worker functions -------------------------------------------------------- + +insert_source <- function(repo_spec, name, + collection = "posts", + branch = "main", + host = "https://github.com", + text = "Source", + file_name) { + path <- paste( + host, + repo_spec, + "tree", + branch, + collection, + name, + file_name, + sep = "/" + ) + return(markdown_link(text, path)) +} + +insert_timestamp <- function(tzone = Sys.timezone()) { + time <- lubridate::now(tzone = tzone) + stamp <- as.character(time, tz = tzone, usetz = TRUE) + return(stamp) +} + +insert_lockfile <- function(repo_spec, name, + collection = "posts", + branch = "main", + host = "https://github.com", + text = "Session info") { + path <- path <- "https://pharmaverse.github.io/blog/session_info.html" + + return(markdown_link(text, path)) +} + + + +# top level function ------------------------------------------------------ + +insert_appendix <- function(repo_spec, name, collection = "posts", file_name) { + appendices <- paste( + markdown_appendix( + name = "Last updated", + content = insert_timestamp() + ), + " ", + markdown_appendix( + name = "Details", + content = paste( + insert_source(repo_spec, name, collection, file_name = file_name), + # get renv information, + insert_lockfile(repo_spec, name, collection), + sep = ", " + ) + ), + sep = "\n" + ) + knitr::asis_output(appendices) +} diff --git a/posts/zzz_DO_NOT_EDIT_a_nca/pharmaverse.png b/posts/zzz_DO_NOT_EDIT_a_nca/pharmaverse.png new file mode 100644 index 00000000..7ee40c66 Binary files /dev/null and b/posts/zzz_DO_NOT_EDIT_a_nca/pharmaverse.png differ