From 11a337fe4a4b911c87bdf52ffc6ed7d8f5cfc320 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Mon, 5 Aug 2024 17:28:05 -0700 Subject: [PATCH 01/31] attempt zero --- .Rbuildignore | 1 + data-raw/example_qs-rda.R | 218 ++++++++++++++++++++++++++++++++++++++ 2 files changed, 219 insertions(+) create mode 100644 data-raw/example_qs-rda.R diff --git a/.Rbuildignore b/.Rbuildignore index ec2b02aa4a..a72ddfa6fe 100644 --- a/.Rbuildignore +++ b/.Rbuildignore @@ -31,3 +31,4 @@ ^\.devcontainer$ ^vignettes/articles$ ^inst/cheatsheet$ +^data-raw$ diff --git a/data-raw/example_qs-rda.R b/data-raw/example_qs-rda.R new file mode 100644 index 0000000000..13a0124f73 --- /dev/null +++ b/data-raw/example_qs-rda.R @@ -0,0 +1,218 @@ +## code to prepare `example_qs.rda` dataset goes here + +## Setup steps: +## - usethis::use_data_raw(name="example_qs") +## - edit script data-raw/example-qs.R +## +## - check: last line usethis::use_data(example_qs.rda, overwrite = TRUE) + +library(admiraldev) +library(dplyr) +# nolint start +suppress_warning( + qs_gad7 <- tibble::tribble( + ~QSSEQ, ~QSTESTCD, ~QSTEST, ~VISIT, ~VISITNUM, ~QSDTC, ~QSORRES, + 1L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "VISIT 1", 1, "2012-11-16", "More than half the days", + 2L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "VISIT 1", 1, "2012-11-16", "More than half the days", + 3L, "GAD0203", "GAD02-Worrying Too Much About Things", "VISIT 1", 1, "2012-11-16", "More than half the days", + 4L, "GAD0204", "GAD02-Trouble Relaxing", "VISIT 1", 1, "2012-11-16", "More than half the days", + 5L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "VISIT 1", 1, "2012-11-16", "Nearly every day", + 6L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "VISIT 1", 1, "2012-11-16", "Nearly every day", + 7L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "VISIT 1", 1, "2012-11-16", "Several days", + 8L, "GAD0208", "GAD02-Total Score", "VISIT 1", 1, "2012-11-16", "15", + 9L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", + 10L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", + 11L, "GAD0203", "GAD02-Worrying Too Much About Things", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", + 12L, "GAD0204", "GAD02-Trouble Relaxing", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", + 13L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "Several days", + 14L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "Nearly every day", + 15L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", + 16L, "GAD0208", "GAD02-Total Score", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "14", + 17L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "VISIT 6", 6, "2013-05-15", "More than half the days", + 18L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "VISIT 6", 6, "2013-05-15", "More than half the days", + 19L, "GAD0203", "GAD02-Worrying Too Much About Things", "VISIT 6", 6, "2013-05-15", "More than half the days", + 20L, "GAD0204", "GAD02-Trouble Relaxing", "VISIT 6", 6, "2013-05-15", "More than half the days", + 21L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "VISIT 6", 6, "2013-05-15", "Several days", + 22L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "VISIT 6", 6, "2013-05-15", "Nearly every day", + 23L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "VISIT 6", 6, "2013-05-15", "Several days", + 24L, "GAD0208", "GAD02-Total Score", "VISIT 6", 6, "2013-05-15", "13", + 25L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "VISIT 12", 12, "2013-11-14", "Several days", + 26L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "VISIT 12", 12, "2013-11-14", "Several days", + 27L, "GAD0203", "GAD02-Worrying Too Much About Things", "VISIT 12", 12, "2013-11-14", "Several days", + 28L, "GAD0204", "GAD02-Trouble Relaxing", "VISIT 12", 12, "2013-11-14", "Several days", + 29L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "VISIT 12", 12, "2013-11-14", "Several days", + 30L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "VISIT 12", 12, "2013-11-14", "Several days", + 31L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "VISIT 12", 12, "2013-11-14", "Several days", + 32L, "GAD0208", "GAD02-Total Score", "VISIT 12", 12, "2013-11-14", "7" + ) %>% + mutate( + QSCAT = "GAD-7 V2", + QSSTRESN = recode( + QSORRES, + "Not at all" = 0L, + "Several days" = 1L, + "More than half the days" = 2L, + "Nearly every day" = 3L, + .default = as.integer(QSORRES) + ) + ) %>% + mutate( + USUBJID = "P0001", + .before = everything() + ), + regexpr = "NAs introduced by coercion" +) +qs_gdssf <- tibble::tribble( + ~USUBJID, ~QSSEQ, ~QSTEST, ~QSTESTCD, ~VISIT, ~VISITNUM, ~QSDTC, ~QSORRES, ~QSSTRESN, + "P0001", 1L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 1", 1, "2012-11-16", "YES", 0L, + "P0001", 2L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 3L, "GDS02-Life Is Empty", "GDS0203", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0001", 4L, "GDS02-Bored Often", "GDS0204", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 5L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 1", 1, "2012-11-16", "NO", 1L, + "P0001", 6L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 7L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 1", 1, "2012-11-16", "NO", 1L, + "P0001", 8L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 9L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0001", 10L, "GDS02-Memory Problems", "GDS0210", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 11L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 1", 1, "2012-11-16", "NO", 1L, + "P0001", 12L, "GDS02-Feel Worthless", "GDS0212", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 13L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 1", 1, "2012-11-16", "YES", 0L, + "P0001", 14L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", 15L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0001", 16L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 2", 2, "2012-12-15", "YES", 0L, + "P0001", 17L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", 18L, "GDS02-Life Is Empty", "GDS0203", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", 19L, "GDS02-Bored Often", "GDS0204", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0001", 20L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 2", 2, "2012-12-15", "NO", 1L, + "P0001", 21L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0001", 22L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 2", 2, "2012-12-15", "NO", 1L, + "P0001", 23L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0001", 24L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", 25L, "GDS02-Memory Problems", "GDS0210", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", 26L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 2", 2, "2012-12-15", "NO", 1L, + "P0001", 27L, "GDS02-Feel Worthless", "GDS0212", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0001", 28L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 2", 2, "2012-12-15", "YES", 0L, + "P0001", 29L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0001", 30L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", 31L, "GDS02-Satisfied With Life", "GDS0201", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 0L, + "P0001", 32L, "GDS02-Dropped Activities and Interests", "GDS0202", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, + "P0001", 33L, "GDS02-Life Is Empty", "GDS0203", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, + "P0001", 34L, "GDS02-Bored Often", "GDS0204", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, + "P0001", 35L, "GDS02-Good Spirits Most of Time", "GDS0205", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 1L, + "P0001", 36L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, + "P0001", 37L, "GDS02-Feel Happy Most of Time", "GDS0207", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, + "P0001", 38L, "GDS02-Often Feel Helpless", "GDS0208", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, + "P0001", 39L, "GDS02-Prefer to Stay Home", "GDS0209", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, + "P0001", 40L, "GDS02-Memory Problems", "GDS0210", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, + "P0001", 41L, "GDS02-Wonderful to Be Alive", "GDS0211", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 1L, + "P0001", 42L, "GDS02-Feel Worthless", "GDS0212", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, + "P0001", 43L, "GDS02-Feel Full of Energy", "GDS0213", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 0L, + "P0001", 44L, "GDS02-Feel Hopeless", "GDS0214", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, + "P0001", 45L, "GDS02-Most People Better Off Than You", "GDS0215", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, + "P0001", 46L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 3", 3, "2013-01-12", NA, NA, + "P0001", 47L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 3", 3, "2013-01-12", NA, NA, + "P0001", 48L, "GDS02-Life Is Empty", "GDS0203", "VISIT 3", 3, "2013-01-12", "NO", 0L, + "P0001", 49L, "GDS02-Bored Often", "GDS0204", "VISIT 3", 3, "2013-01-12", "NO", 0L, + "P0001", 50L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 3", 3, "2013-01-12", "YES", 0L, + "P0001", 51L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 3", 3, "2013-01-12", "YES", 1L, + "P0001", 52L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 3", 3, "2013-01-12", "NO", 1L, + "P0001", 53L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 3", 3, "2013-01-12", "YES", 1L, + "P0001", 54L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 3", 3, "2013-01-12", "NO", 0L, + "P0001", 55L, "GDS02-Memory Problems", "GDS0210", "VISIT 3", 3, "2013-01-12", "NO", 0L, + "P0001", 56L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 3", 3, "2013-01-12", "NO", 1L, + "P0001", 57L, "GDS02-Feel Worthless", "GDS0212", "VISIT 3", 3, "2013-01-12", "YES", 1L, + "P0001", 58L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 3", 3, "2013-01-12", "YES", 0L, + "P0001", 59L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 3", 3, "2013-01-12", "YES", 1L, + "P0001", 60L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 3", 3, "2013-01-12", "NO", 0L, + "P0001", 61L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 4", 4, "2013-02-13", "YES", 0L, + "P0001", 62L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 63L, "GDS02-Life Is Empty", "GDS0203", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 64L, "GDS02-Bored Often", "GDS0204", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 65L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 4", 4, "2013-02-13", "YES", 0L, + "P0001", 66L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0001", 67L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0001", 68L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 69L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 70L, "GDS02-Memory Problems", "GDS0210", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 71L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0001", 72L, "GDS02-Feel Worthless", "GDS0212", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 73L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 4", 4, "2013-02-13", "YES", 0L, + "P0001", 74L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", 75L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0002", 1L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 1", 1, "2012-11-16", "YES", 0L, + "P0002", 2L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0002", 3L, "GDS02-Life Is Empty", "GDS0203", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 4L, "GDS02-Bored Often", "GDS0204", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0002", 5L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 1", 1, "2012-11-16", "NO", 1L, + "P0002", 6L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 7L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 1", 1, "2012-11-16", "NO", 1L, + "P0002", 8L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 9L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 10L, "GDS02-Memory Problems", "GDS0210", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 11L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 1", 1, "2012-11-16", "YES", 0L, + "P0002", 12L, "GDS02-Feel Worthless", "GDS0212", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 13L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 1", 1, "2012-11-16", "YES", 0L, + "P0002", 14L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 15L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0002", 16L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 2", 2, "2012-12-15", "YES", 0L, + "P0002", 17L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0002", 18L, "GDS02-Life Is Empty", "GDS0203", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0002", 19L, "GDS02-Bored Often", "GDS0204", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0002", 20L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 2", 2, "2012-12-15", "NO", 1L, + "P0002", 21L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0002", 22L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 2", 2, "2012-12-15", "NO", 1L, + "P0002", 23L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0002", 24L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 2", 2, "2012-12-15", "YES", 1L, + "P0002", 25L, "GDS02-Memory Problems", "GDS0210", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0002", 26L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 2", 2, "2012-12-15", "YES", 0L, + "P0002", 27L, "GDS02-Feel Worthless", "GDS0212", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0002", 28L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 2", 2, "2012-12-15", "YES", 0L, + "P0002", 29L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0002", 30L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0002", 46L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0002", 47L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 48L, "GDS02-Life Is Empty", "GDS0203", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0002", 49L, "GDS02-Bored Often", "GDS0204", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 50L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0002", 51L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 52L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0002", 53L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 54L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 55L, "GDS02-Memory Problems", "GDS0210", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 56L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0002", 57L, "GDS02-Feel Worthless", "GDS0212", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 58L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 4", 4, "2013-02-13", "NO", 1L, + "P0002", 59L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0002", 60L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 4", 4, "2013-02-13", "NO", 0L +) %>% + mutate(QSCAT = "GDS SHORT FORM") + +qs_sp <- tibble::tribble( + ~USUBJID, ~QSTEST, ~QSTESTCD, ~VISIT, ~VISITNUM, ~QSDTC, ~QSORRES, ~QSSTRESN, + "P0001", "SP01-No sleep at all", "SP0101", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0001", "SP01-Waking up more than three times", "SP0102", "VISIT 1", 1, "2012-11-16", "NO", 0L, + "P0001", "SP01-More than 30 mins to fall asleep", "SP0103", "VISIT 1", 1, "2012-11-16", "YES", 1L, + "P0001", "SP01-No sleep at all", "SP0101", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", "SP01-Waking up more than three times", "SP0102", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", "SP01-More than 30 mins to fall asleep", "SP0103", "VISIT 2", 2, "2012-12-15", "NO", 0L, + "P0001", "SP01-No sleep at all", "SP0101", "VISIT 4", 4, "2013-02-13", "NO", 0L, + "P0001", "SP01-Waking up more than three times", "SP0102", "VISIT 4", 4, "2013-02-13", "YES", 1L, + "P0001", "SP01-More than 30 mins to fall asleep", "SP0103", "VISIT 4", 4, "2013-02-13", "YES", 1L, +) %>% + mutate( + QSSEQ = row_number(), + QSCAT = "SLEEPING PROBLEMS", + .after = USUBJID + ) + +# nolint end +example_qs <- bind_rows(qs_gad7, qs_gdssf, qs_sp) %>% + mutate( + STUDYID = "STUDYX", + .before = everything() + ) + +#save(example_qs, file = file.path("data", "example_qs.rda"), compress = "bzip2") + +example_qs_new=example_qs +usethis::use_data(example_qs_new, overwrite = TRUE) From eaea9d65db6234089e2fb3104bb7376ab2e615c7 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Thu, 8 Aug 2024 15:50:06 -0700 Subject: [PATCH 02/31] 2427_adopt_data_data_raw_conventions-FIrst --- data-raw/{example_qs-rda.R => example_qs.R} | 1 + data-raw/test.R | 23 ++++++++++++++++++++ data/example_qs.rda | Bin 1885 -> 1885 bytes 3 files changed, 24 insertions(+) rename data-raw/{example_qs-rda.R => example_qs.R} (99%) create mode 100644 data-raw/test.R diff --git a/data-raw/example_qs-rda.R b/data-raw/example_qs.R similarity index 99% rename from data-raw/example_qs-rda.R rename to data-raw/example_qs.R index 13a0124f73..5495e3ec74 100644 --- a/data-raw/example_qs-rda.R +++ b/data-raw/example_qs.R @@ -216,3 +216,4 @@ example_qs <- bind_rows(qs_gad7, qs_gdssf, qs_sp) %>% example_qs_new=example_qs usethis::use_data(example_qs_new, overwrite = TRUE) + diff --git a/data-raw/test.R b/data-raw/test.R new file mode 100644 index 0000000000..4cd9b3b799 --- /dev/null +++ b/data-raw/test.R @@ -0,0 +1,23 @@ +# +# Test: +# In folder data/ files should contain identical R objects: + +# example_qs.rda was created in via script inst/example_scripts/example_qs.R +# example_qs_new.rda was created by NEWER method, script data-raw/example_qs_new.R + +# Run both methods, create the 2 *.rda files: +source("data-raw/example_qs.r") +source("inst/example_scripts/example_qs.R") + + +## Please restart R or remove objects in environment + +# load stored objects into environment +# original method +load("data/example_qs.rda") + +# newer method +load("data/example_qs_new.rda") + + +identical(example_qs_new, example_qs) diff --git a/data/example_qs.rda b/data/example_qs.rda index df81153271f48b27135ab402461320fd424eb2f9..d8d0783ae282d323fb127f36859d89119acd07f5 100644 GIT binary patch delta 1864 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95b4eca6a84936540d6ef858613597eeb35806fa Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Fri, 16 Aug 2024 16:48:56 -0700 Subject: [PATCH 03/31] 2427 ..DRAFT .. except for a few comments to be removed, this is almost PR --- data-raw/example_qs.R | 12 ++++-------- 1 file changed, 4 insertions(+), 8 deletions(-) diff --git a/data-raw/example_qs.R b/data-raw/example_qs.R index 5495e3ec74..bc938fea24 100644 --- a/data-raw/example_qs.R +++ b/data-raw/example_qs.R @@ -1,12 +1,8 @@ -## code to prepare `example_qs.rda` dataset goes here +## Code to create `example_qs.rda` dataset and save it in data/ +## This replaces inst/example_scripts/example_qs.R +## Follows the same standard as pharmaversesdtm -## Setup steps: -## - usethis::use_data_raw(name="example_qs") -## - edit script data-raw/example-qs.R -## -## - check: last line usethis::use_data(example_qs.rda, overwrite = TRUE) -library(admiraldev) library(dplyr) # nolint start suppress_warning( @@ -212,8 +208,8 @@ example_qs <- bind_rows(qs_gad7, qs_gdssf, qs_sp) %>% .before = everything() ) +## TO BE REMOVED #save(example_qs, file = file.path("data", "example_qs.rda"), compress = "bzip2") example_qs_new=example_qs usethis::use_data(example_qs_new, overwrite = TRUE) - From 2bd429004eb92b9c153ef92a740ef79a2d1c850c Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Fri, 23 Aug 2024 12:13:08 -0700 Subject: [PATCH 04/31] Issue 2427 first serious attempt for example_qs.rda, see comments --- data-raw/example_qs.R | 11 ++++------- data-raw/test.R | 27 +++++++++++++++++---------- old_data/example_qs.rda | Bin 0 -> 1885 bytes 3 files changed, 21 insertions(+), 17 deletions(-) create mode 100644 old_data/example_qs.rda diff --git a/data-raw/example_qs.R b/data-raw/example_qs.R index bc938fea24..484ef3dbbd 100644 --- a/data-raw/example_qs.R +++ b/data-raw/example_qs.R @@ -1,9 +1,10 @@ ## Code to create `example_qs.rda` dataset and save it in data/ ## This replaces inst/example_scripts/example_qs.R -## Follows the same standard as pharmaversesdtm +## Follows the same standard as pharmaversesdtm library(dplyr) +library(admiraldev) # nolint start suppress_warning( qs_gad7 <- tibble::tribble( @@ -207,9 +208,5 @@ example_qs <- bind_rows(qs_gad7, qs_gdssf, qs_sp) %>% STUDYID = "STUDYX", .before = everything() ) - -## TO BE REMOVED -#save(example_qs, file = file.path("data", "example_qs.rda"), compress = "bzip2") - -example_qs_new=example_qs -usethis::use_data(example_qs_new, overwrite = TRUE) +# create example_qs.rda in data/ +usethis::use_data(example_qs, overwrite = TRUE) diff --git a/data-raw/test.R b/data-raw/test.R index 4cd9b3b799..55a84a285e 100644 --- a/data-raw/test.R +++ b/data-raw/test.R @@ -1,23 +1,30 @@ + # # Test: -# In folder data/ files should contain identical R objects: +# Newly created *.rda files in folder data/ MUST BE IDENTICAL to old_data/*.rda -# example_qs.rda was created in via script inst/example_scripts/example_qs.R -# example_qs_new.rda was created by NEWER method, script data-raw/example_qs_new.R +# *.rda file in old_data/ is copy of file created in via script inst/example_scripts/example_qs.R # Run both methods, create the 2 *.rda files: -source("data-raw/example_qs.r") -source("inst/example_scripts/example_qs.R") +source("data-raw/example_qs.R") # new +source("inst/example_scripts/example_qs.R") # old ## Please restart R or remove objects in environment -# load stored objects into environment -# original method +# Load stored objects into environments +# Because `load` places objects in current environment, put old_data in a new environment + +# For created data, place object into current_env load("data/example_qs.rda") -# newer method -load("data/example_qs_new.rda") +# But create new environment for old_data/ +e <- new_environment() +load("old_data/example_qs.rda", envir = e) + +# test +identical(example_qs, e$example_qs) -identical(example_qs_new, example_qs) +# cleanup: remove e +rm(e) diff --git a/old_data/example_qs.rda b/old_data/example_qs.rda new file mode 100644 index 0000000000000000000000000000000000000000..d8d0783ae282d323fb127f36859d89119acd07f5 GIT binary patch literal 1885 zcmV-j2cq~wT4*^jL0KkKS@oDjGyo_^f6)K`|NsC0|NsC0|KPvx|KPv?AOJuC;0pfu zjNf)dX`lcCr~oJc009X}QKm+Wnhi7=20%120}+UNj}Z+9fChkIfMm!V0002c0009( z4FCYp00Te(00F=N01W^D05ky501W^DGynhq4LwRw001-q00u^Y4FCWD00000Fp5G` zYHE22=^IdKqeDldP&5Dl27&5m0000P00B}&6GCW)nrWbFWYqF%Y*SBDO&*{PF)|EH zm=Mrt$)=u=Y3Zp{wpuVOEzIBGET9`=$QB^US}an=Bq_~-mdnp2PaP%c2Ng%vyV&%3 zta-|@#iWsB>LiAe^`Fsx&DM>LU|B*^10auHQH$|OdviG;jK2MJOmj7M^k z6cWp^wMQkXOFwLQ7vy zDyXSSm3npoBngHPG7<(5Fp~lRKmZWL3_%eD8FG?)?*V(iArX)%6?rxOdql6hnaxwz z1Z(%}nK3alJEo($a|=nHV=jwgF&FsW@zHhtRZc{vxO!p5Cm8jV>khn zr)g@MuBXiJV(h|5U$W&QU3_)q86b>|_z9iiG6gkDL)4-J7YC{&^qD4DAo zNm6|tJRI|YS(w>AXc5qeg7aBFJdx_jF+%Vo7?F&zFoDw>;)03=6bdLx6ev)lg%l{E zMG7cULW%-ap!|YKh{R?-LGh1Fe8c*S514#oAwE&GNjOJ4mPqJ{ClE{f+@1J$ zh=xQ%A?1`a_v^1DV++Fpuwm8`PFP+?>4`%UGy2f&q#C4-$Gl``Czg0<8$? z3W6>uTU@xIMHD=^5#iV8!blJjfOxuk9dx`0P#?Q6lAV-ma5KPvs#L^%aW$QC^KDO4 zq%K(6C`x+Aym?2mD6!JmXkaWd8{)$;L)#p}#g0A1nGfB-c>IEcP9g1=93~T@EHM;x zB4HuAUONUyurVA1+$}u-nWctCqDOGlEOf_!W-vNoL(dr{#`xyQu%rH68%^L|f z90LMy4xElNqqmSZ#Rj;T&4Iu?@$L?(J)4KLa1I$HZxmQ~&LOrXPWY%r6(ik}b_vZF zAE+qbG7C*(l;cEuO{Mm3KIjWSYa^B0NyKzVq;-#AY%?4KL9Ed32U>Q<(6G3h=F`p^9H$A@FT`$6 zoadcELW#sIH*$*(krx<__MwSG>k_0^MdXvpo@m5P<9uXbIS;TnPotFB8p;%F71^&R znIzUc;?Tr7!iH0b)-Gl+7##`B9LYIlVoA74B^rh%W-{SdFgVA9@ALy`+A|wLw4Bjt zaiM9jb;j{|69Z9kkkmN_;&PkB@C|bUW;2pd-Y?oP+-)jvjv;QTLvYZSG%PR^zCAak XQa#8d93Ueo|BJaIoG3_o%p#fqRRk?4 literal 0 HcmV?d00001 From f16131d3c8e86db48564f57a639f127ff139c713 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Sat, 24 Aug 2024 17:01:43 -0700 Subject: [PATCH 05/31] 2427_ ran spelling, styler, lintr, but it dislikes use of source() --- data-raw/test.R | 5 ++--- inst/WORDLIST | 1 + 2 files changed, 3 insertions(+), 3 deletions(-) diff --git a/data-raw/test.R b/data-raw/test.R index 55a84a285e..41f850057d 100644 --- a/data-raw/test.R +++ b/data-raw/test.R @@ -1,4 +1,3 @@ - # # Test: # Newly created *.rda files in folder data/ MUST BE IDENTICAL to old_data/*.rda @@ -6,8 +5,8 @@ # *.rda file in old_data/ is copy of file created in via script inst/example_scripts/example_qs.R # Run both methods, create the 2 *.rda files: -source("data-raw/example_qs.R") # new -source("inst/example_scripts/example_qs.R") # old +source("data-raw/example_qs.R") # new +source("inst/example_scripts/example_qs.R") # old ## Please restart R or remove objects in environment diff --git a/inst/WORDLIST b/inst/WORDLIST index ad1b8d709e..465167679b 100644 --- a/inst/WORDLIST +++ b/inst/WORDLIST @@ -193,6 +193,7 @@ README Rahal Ratford Romain +Rothstein SCE SCN SCOPEN From 05d16aa741b635bd37dc1a53b1106dcd107390f8 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Sun, 25 Aug 2024 12:12:25 -0700 Subject: [PATCH 06/31] 2427 removed data-raw/test.R and old_data/example_qs.rda. This means no more testing. The file data/example_qs.rda will be used, going forward. --- data-raw/test.R | 29 ----------------------------- old_data/example_qs.rda | Bin 1885 -> 0 bytes 2 files changed, 29 deletions(-) delete mode 100644 data-raw/test.R delete mode 100644 old_data/example_qs.rda diff --git a/data-raw/test.R b/data-raw/test.R deleted file mode 100644 index 41f850057d..0000000000 --- a/data-raw/test.R +++ /dev/null @@ -1,29 +0,0 @@ -# -# Test: -# Newly created *.rda files in folder data/ MUST BE IDENTICAL to old_data/*.rda - -# *.rda file in old_data/ is copy of file created in via script inst/example_scripts/example_qs.R - -# Run both methods, create the 2 *.rda files: -source("data-raw/example_qs.R") # new -source("inst/example_scripts/example_qs.R") # old - - -## Please restart R or remove objects in environment - -# Load stored objects into environments -# Because `load` places objects in current environment, put old_data in a new environment - -# For created data, place object into current_env -load("data/example_qs.rda") - -# But create new environment for old_data/ -e <- new_environment() -load("old_data/example_qs.rda", envir = e) - - -# test -identical(example_qs, e$example_qs) - -# cleanup: remove e -rm(e) diff --git a/old_data/example_qs.rda b/old_data/example_qs.rda deleted file mode 100644 index d8d0783ae282d323fb127f36859d89119acd07f5..0000000000000000000000000000000000000000 GIT binary patch literal 0 HcmV?d00001 literal 1885 zcmV-j2cq~wT4*^jL0KkKS@oDjGyo_^f6)K`|NsC0|NsC0|KPvx|KPv?AOJuC;0pfu zjNf)dX`lcCr~oJc009X}QKm+Wnhi7=20%120}+UNj}Z+9fChkIfMm!V0002c0009( z4FCYp00Te(00F=N01W^D05ky501W^DGynhq4LwRw001-q00u^Y4FCWD00000Fp5G` zYHE22=^IdKqeDldP&5Dl27&5m0000P00B}&6GCW)nrWbFWYqF%Y*SBDO&*{PF)|EH zm=Mrt$)=u=Y3Zp{wpuVOEzIBGET9`=$QB^US}an=Bq_~-mdnp2PaP%c2Ng%vyV&%3 zta-|@#iWsB>LiAe^`Fsx&DM>LU|B*^10auHQH$|OdviG;jK2MJOmj7M^k z6cWp^wMQkXOFwLQ7vy zDyXSSm3npoBngHPG7<(5Fp~lRKmZWL3_%eD8FG?)?*V(iArX)%6?rxOdql6hnaxwz z1Z(%}nK3alJEo($a|=nHV=jwgF&FsW@zHhtRZc{vxO!p5Cm8jV>khn zr)g@MuBXiJV(h|5U$W&QU3_)q86b>|_z9iiG6gkDL)4-J7YC{&^qD4DAo zNm6|tJRI|YS(w>AXc5qeg7aBFJdx_jF+%Vo7?F&zFoDw>;)03=6bdLx6ev)lg%l{E zMG7cULW%-ap!|YKh{R?-LGh1Fe8c*S514#oAwE&GNjOJ4mPqJ{ClE{f+@1J$ zh=xQ%A?1`a_v^1DV++Fpuwm8`PFP+?>4`%UGy2f&q#C4-$Gl``Czg0<8$? z3W6>uTU@xIMHD=^5#iV8!blJjfOxuk9dx`0P#?Q6lAV-ma5KPvs#L^%aW$QC^KDO4 zq%K(6C`x+Aym?2mD6!JmXkaWd8{)$;L)#p}#g0A1nGfB-c>IEcP9g1=93~T@EHM;x zB4HuAUONUyurVA1+$}u-nWctCqDOGlEOf_!W-vNoL(dr{#`xyQu%rH68%^L|f z90LMy4xElNqqmSZ#Rj;T&4Iu?@$L?(J)4KLa1I$HZxmQ~&LOrXPWY%r6(ik}b_vZF zAE+qbG7C*(l;cEuO{Mm3KIjWSYa^B0NyKzVq;-#AY%?4KL9Ed32U>Q<(6G3h=F`p^9H$A@FT`$6 zoadcELW#sIH*$*(krx<__MwSG>k_0^MdXvpo@m5P<9uXbIS;TnPotFB8p;%F71^&R znIzUc;?Tr7!iH0b)-Gl+7##`B9LYIlVoA74B^rh%W-{SdFgVA9@ALy`+A|wLw4Bjt zaiM9jb;j{|69Z9kkkmN_;&PkB@C|bUW;2pd-Y?oP+-)jvjv;QTLvYZSG%PR^zCAak XQa#8d93Ueo|BJaIoG3_o%p#fqRRk?4 From f70b75e77ff41784db35626cac38f28a1ce0ba00 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Mon, 26 Aug 2024 11:09:53 -0700 Subject: [PATCH 07/31] 2427 EXPERIMENT ... data-raw/example_qs.R ... commented out library calls --- data-raw/example_qs.R | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data-raw/example_qs.R b/data-raw/example_qs.R index 484ef3dbbd..f4b1175ea3 100644 --- a/data-raw/example_qs.R +++ b/data-raw/example_qs.R @@ -3,8 +3,8 @@ ## Follows the same standard as pharmaversesdtm -library(dplyr) -library(admiraldev) +#library(dplyr) +#library(admiraldev) # nolint start suppress_warning( qs_gad7 <- tibble::tribble( From 6e4153539d268d94224e41c3383eb1e94a409185 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Mon, 26 Aug 2024 11:25:06 -0700 Subject: [PATCH 08/31] EXPERIMENT 2 - remove unnecessary commnets; style_pkg() - no errors, does check example_qs.R lint() reports no errors. --- data-raw/example_qs.R | 2 -- 1 file changed, 2 deletions(-) diff --git a/data-raw/example_qs.R b/data-raw/example_qs.R index f4b1175ea3..1286e93352 100644 --- a/data-raw/example_qs.R +++ b/data-raw/example_qs.R @@ -3,8 +3,6 @@ ## Follows the same standard as pharmaversesdtm -#library(dplyr) -#library(admiraldev) # nolint start suppress_warning( qs_gad7 <- tibble::tribble( From 14e144b6706ef6140856d293c4fc96819c1937a8 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Mon, 26 Aug 2024 12:15:19 -0700 Subject: [PATCH 09/31] EXPERIMENT 3 - hys_law.Rmd missing close paraenthesis at end of FDA url. --- data/example_qs.rda | Bin 1885 -> 1888 bytes 1 file changed, 0 insertions(+), 0 deletions(-) diff --git a/data/example_qs.rda b/data/example_qs.rda index d8d0783ae282d323fb127f36859d89119acd07f5..7274ba766569233f077c093663e2c3806fe1b977 100644 GIT binary patch delta 1883 zcmV-h2c-Dj4&V+ELRx4!F+o`-Q(1qZC^G;kLy-|2f2%jq#BHbm0H6RU0004msUl(x zGBjzXMkb9k8W|WM!8FXKAY^HTG-w$HLl6!C003wJ00E!|fB00006o~bAR0imD(8Z@QiKdzXrkG5I(rr&6G zVg-f0w*CUj0kl~H#2E`kidBsYa?r}t?5X6W*GM=jKE0jqTb##vRyZ`t7EUfbSD6{` z=$ZsdNHyb)WgD3!jFBcW&@Xu*9TJHVp9zG#e@O=UQX`^Qe+vo;Yp%tkkla$wwzcB; 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z3M6BqkQfhiMWl+UC7_iI1ww`}N*D`CF9{U{xS)J@5V*L#g`k$GMobANP{5jrDw5aif_fVRSfMcScwunBP@zogkqVdseEc}* zs%QWWpb<+GRMNH}M!~0wNcCijLnvqdp(dv0_?oR@B+!Z!MGN{c`N8lX3GfRa;Q3F8 z{Gj}TNr=Q|K0)!1Onk%oiw~H5VjhDWM?OqkZgy9Nj3I_lOV`ZQ;n(NFNDvZ$c)EHWbi4;pAG%rH68%^L|f90LMy4xElN zqqmSZ#Rj;T&4Iu?@$L?(J)4KLa1I$HZxmQ~&LOrXPWY%r6(ik}b_vZFAE+qbG7C*( zl@R#i9_oWq*g`blggfG#7*OTWMDZDusBbnl-L@|6l)dPuP2!#);!|S z#5ux-Q;60sW-u5X3CtYHIb~u=xJo4&h9+h*;a4y?$Aj+ SAR{RMi@744C`fwDBANi|8X`^r From c1d6cc1ae2ef12efbf8b766296c28e3fe4e58103 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Mon, 26 Aug 2024 12:53:25 -0700 Subject: [PATCH 10/31] EXPERIMENT 4 (1) admiraldev is REQUIRED or vignette won't build (2) added admiral per Hadley, but truly needed? --- vignettes/hys_law.Rmd | 1 + 1 file changed, 1 insertion(+) diff --git a/vignettes/hys_law.Rmd b/vignettes/hys_law.Rmd index 95df56e868..1bb7b5702e 100644 --- a/vignettes/hys_law.Rmd +++ b/vignettes/hys_law.Rmd @@ -13,6 +13,7 @@ knitr::opts_chunk$set( comment = "#>" ) +library(admiral) library(admiraldev) ``` From 732febc314499153e62fde4bb05e9d6b7c72dc53 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Tue, 27 Aug 2024 17:51:39 -0700 Subject: [PATCH 11/31] 2427 Add URL: https://www.fda.gov/media/116737/download to .lycheeignore because github actions reports 404. But the link is good. --- .Rbuildignore | 1 + .gitignore | 2 ++ .lycheeignore | 1 + 3 files changed, 4 insertions(+) diff --git a/.Rbuildignore b/.Rbuildignore index a72ddfa6fe..c7366abf79 100644 --- a/.Rbuildignore +++ b/.Rbuildignore @@ -32,3 +32,4 @@ ^vignettes/articles$ ^inst/cheatsheet$ ^data-raw$ +^doc$ diff --git a/.gitignore b/.gitignore index 2a6f8564ba..db7075c835 100644 --- a/.gitignore +++ b/.gitignore @@ -54,3 +54,5 @@ admiral*.tgz ._.DS_Store .Rprofile +/doc/ +/Meta/ diff --git a/.lycheeignore b/.lycheeignore index cd1db91901..58c2c800f5 100644 --- a/.lycheeignore +++ b/.lycheeignore @@ -6,3 +6,4 @@ https://packagemanager.rstudio.com/cran/__linux__/focal/latest https://raw.githubusercontent.com/pharmaverse/admiral/main/inst/cheatsheet/cheatsheet_image.png https://rsc.niaid.nih.gov/clinical-research-sites/daids-adverse-event-grading-tables https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf +https://www.fda.gov/media/116737/download \ No newline at end of file From b1c9ab504f512c8b5a92e8e64c71b7275fded9e4 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Wed, 28 Aug 2024 09:36:23 -0700 Subject: [PATCH 12/31] 2427 EXPERIMENT, remove fda from .lycheeignore; change title of fda link --- .lycheeignore | 3 +-- vignettes/hys_law.Rmd | 4 +++- 2 files changed, 4 insertions(+), 3 deletions(-) diff --git a/.lycheeignore b/.lycheeignore index 58c2c800f5..7c04ee6134 100644 --- a/.lycheeignore +++ b/.lycheeignore @@ -5,5 +5,4 @@ irongut/CodeCoverageSummary@v1.2.0 https://packagemanager.rstudio.com/cran/__linux__/focal/latest https://raw.githubusercontent.com/pharmaverse/admiral/main/inst/cheatsheet/cheatsheet_image.png https://rsc.niaid.nih.gov/clinical-research-sites/daids-adverse-event-grading-tables -https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf -https://www.fda.gov/media/116737/download \ No newline at end of file +https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf \ No newline at end of file diff --git a/vignettes/hys_law.Rmd b/vignettes/hys_law.Rmd index 1bb7b5702e..07328f8f28 100644 --- a/vignettes/hys_law.Rmd +++ b/vignettes/hys_law.Rmd @@ -19,7 +19,9 @@ library(admiraldev) # Introduction -During the drug development process, clinical trials are often required to assess for the potential that the experimental drug can cause severe liver injury, known as a drug induced liver injury [(DILI)](https://www.fda.gov/media/116737/download). There are multiple criteria that need to be evaluated to determine and classify a DILI "Event". Hy's Law, a common rule of thumb for a DILI Event , is usually comprised of three parts: +During the drug development process, clinical trials are often required to assess for the potential that the experimental drug can cause severe liver injury, known as a drug induced liver injury (DILI) [Drug-Induced Liver Injury: +Premarketing Clinical +Evaluation](https://www.fda.gov/media/116737/download). There are multiple criteria that need to be evaluated to determine and classify a DILI "Event". Hy's Law, a common rule of thumb for a DILI Event , is usually comprised of three parts: - Elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) by 3-times or greater of the upper limit of normal. - Elevated serum total bilirubin (BILI) by 2-times or greater within a window of time, ~14 days after the elevated ALT/AST event. From 4c75094a05ccdc2aeb0fc510a7be1aeabc31a748 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Wed, 28 Aug 2024 09:38:12 -0700 Subject: [PATCH 13/31] 2427 EXPERIMENT restore fda link to .ycheeignore; it is essential --- .lycheeignore | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/.lycheeignore b/.lycheeignore index 7c04ee6134..58c2c800f5 100644 --- a/.lycheeignore +++ b/.lycheeignore @@ -5,4 +5,5 @@ irongut/CodeCoverageSummary@v1.2.0 https://packagemanager.rstudio.com/cran/__linux__/focal/latest https://raw.githubusercontent.com/pharmaverse/admiral/main/inst/cheatsheet/cheatsheet_image.png https://rsc.niaid.nih.gov/clinical-research-sites/daids-adverse-event-grading-tables -https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf \ No newline at end of file +https://rsc.niaid.nih.gov/sites/default/files/daidsgradingcorrectedv21.pdf +https://www.fda.gov/media/116737/download \ No newline at end of file From bd38b569b2d5cea6000372b9793088dfb6fc3c23 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Wed, 28 Aug 2024 10:03:15 -0700 Subject: [PATCH 14/31] 2427 ... add to WORDLIST --- inst/WORDLIST | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/inst/WORDLIST b/inst/WORDLIST index 5465afbe0a..a7bf5eb09d 100644 --- a/inst/WORDLIST +++ b/inst/WORDLIST @@ -187,6 +187,7 @@ Pharmaverse Phosphatase Pooja Pre +Premarketing QD QID README @@ -309,7 +310,6 @@ pre prev prm quosures -Rothstein recoded renv repo From d50daa42c0337a04e5b360d566d4749b96ff07e2 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Thu, 29 Aug 2024 15:17:18 -0700 Subject: [PATCH 15/31] #2427 derive_single_dose should work. added (temporarily( backup_data/ --- .../derive_single_dose.R | 6 +- .../example_query_source.R | 0 data/ex_single.rda | Bin 89015 -> 88650 bytes inst/example_scripts/example_qs.R | 206 ------------------ 4 files changed, 4 insertions(+), 208 deletions(-) rename {inst/example_scripts => data-raw}/derive_single_dose.R (91%) rename {inst/example_scripts => data-raw}/example_query_source.R (100%) delete mode 100644 inst/example_scripts/example_qs.R diff --git a/inst/example_scripts/derive_single_dose.R b/data-raw/derive_single_dose.R similarity index 91% rename from inst/example_scripts/derive_single_dose.R rename to data-raw/derive_single_dose.R index 17900e05bc..6ceace95a9 100644 --- a/inst/example_scripts/derive_single_dose.R +++ b/data-raw/derive_single_dose.R @@ -1,7 +1,8 @@ library(pharmaversesdtm) library(admiral) library(dplyr) -data(ex) +ex <- pharmaversesdtm::ex + # check that there is only one start/end date of exposure per subject and visit check_cond <- ex %>% @@ -52,4 +53,5 @@ attr(ex_single$EXSTDTC, "label") <- attr(ex$EXSTDTC, "label") attr(ex_single$EXENDTC, "label") <- attr(ex$EXENDTC, "label") attr(ex_single$EXDOSFRQ, "label") <- attr(ex$EXDOSFRQ, "label") -save(ex_single, file = file.path("data", "ex_single.rda"), compress = "bzip2") +#save(ex_single, file = file.path("data", "ex_single.rda"), compress = "bzip2") +usethis::use_data(ex_single, overwrite = TRUE) diff --git a/inst/example_scripts/example_query_source.R b/data-raw/example_query_source.R similarity index 100% rename from inst/example_scripts/example_query_source.R rename to data-raw/example_query_source.R diff --git a/data/ex_single.rda b/data/ex_single.rda index ae359ca0db227cfb74a17c26f1469ae45aae9c13..c0db6a6d814cc0ace50fe3cdb286af6464361c93 100644 GIT binary patch delta 84744 zcmZ^}Wl$VU6D>>#kPrd{cZbE@H3@EuEsHGfEbdMgC%7+8uw7(v4IVVOyCit<1PCtq zp7(xrf8PGlJyTs>r_c1%%vANXwqlMpVZvk~_Tu~>4FMp-JW7!^tn~1I$^Rbh=|7;u zHf6Yfe(PzK`G6LJ_F_}wr!-@+3K+vojzs4TSaG#d5yh@uAIlb^$|#%8%*-68{*f`2 z4XlkeP|2*t!5pEgty{s7P8?gVqVR^T9PNcJn{EnNRY6OKMJMuwYHTH&Y-$QIGcgPy zFJD>qhR}Krh)b@n82&Mh2!n#3@>7Xij-@%1`s+SEG_)6d@p#afkOV%a*Wb|4F#7li z0}x>KEHtA3JQ&|FzP%7;OID4kh&d9lL__O+ult{7XJNnwv7re-ksk|RItWdp&3$Qp z`0+15K9=|JU+vW+?AJ4_;_3bBPgvv9&D?D_3{QnI?!Kk=7~1&{Q;-T{nY=&nVg=s5 z;Vo!@R2(&`E?R@GmT?(D2AfVzqQxhgCW@MQycZYx+aUc7hw1Zk3SLc!A(J#UK^J(M 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z&DslO>ls{JqiU;e%XM>QXAnIhh>E3_J6oH!hg;z2wO?!A_mW>leyRWB?ntK!5)MGz FKwwklR$u@C diff --git a/inst/example_scripts/example_qs.R b/inst/example_scripts/example_qs.R deleted file mode 100644 index f6c6e7ab3a..0000000000 --- a/inst/example_scripts/example_qs.R +++ /dev/null @@ -1,206 +0,0 @@ -library(dplyr) -# nolint start -suppress_warning( - qs_gad7 <- tibble::tribble( - ~QSSEQ, ~QSTESTCD, ~QSTEST, ~VISIT, ~VISITNUM, ~QSDTC, ~QSORRES, - 1L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "VISIT 1", 1, "2012-11-16", "More than half the days", - 2L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "VISIT 1", 1, "2012-11-16", "More than half the days", - 3L, "GAD0203", "GAD02-Worrying Too Much About Things", "VISIT 1", 1, "2012-11-16", "More than half the days", - 4L, "GAD0204", "GAD02-Trouble Relaxing", "VISIT 1", 1, "2012-11-16", "More than half the days", - 5L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "VISIT 1", 1, "2012-11-16", "Nearly every day", - 6L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "VISIT 1", 1, "2012-11-16", "Nearly every day", - 7L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "VISIT 1", 1, "2012-11-16", "Several days", - 8L, "GAD0208", "GAD02-Total Score", "VISIT 1", 1, "2012-11-16", "15", - 9L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", - 10L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", - 11L, "GAD0203", "GAD02-Worrying Too Much About Things", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", - 12L, "GAD0204", "GAD02-Trouble Relaxing", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", - 13L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "Several days", - 14L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "Nearly every day", - 15L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "More than half the days", - 16L, "GAD0208", "GAD02-Total Score", "UNSCHEDULED VISIT 5.01", 501, "2013-04-15", "14", - 17L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "VISIT 6", 6, "2013-05-15", "More than half the days", - 18L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "VISIT 6", 6, "2013-05-15", "More than half the days", - 19L, "GAD0203", "GAD02-Worrying Too Much About Things", "VISIT 6", 6, "2013-05-15", "More than half the days", - 20L, "GAD0204", "GAD02-Trouble Relaxing", "VISIT 6", 6, "2013-05-15", "More than half the days", - 21L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "VISIT 6", 6, "2013-05-15", "Several days", - 22L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "VISIT 6", 6, "2013-05-15", "Nearly every day", - 23L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "VISIT 6", 6, "2013-05-15", "Several days", - 24L, "GAD0208", "GAD02-Total Score", "VISIT 6", 6, "2013-05-15", "13", - 25L, "GAD0201", "GAD02-Feeling Nervous Anxious or On Edge", "VISIT 12", 12, "2013-11-14", "Several days", - 26L, "GAD0202", "GAD02-Not Able to Stop/Control Worrying", "VISIT 12", 12, "2013-11-14", "Several days", - 27L, "GAD0203", "GAD02-Worrying Too Much About Things", "VISIT 12", 12, "2013-11-14", "Several days", - 28L, "GAD0204", "GAD02-Trouble Relaxing", "VISIT 12", 12, "2013-11-14", "Several days", - 29L, "GAD0205", "GAD02-Being Restless Hard to Sit Still", "VISIT 12", 12, "2013-11-14", "Several days", - 30L, "GAD0206", "GAD02-Becoming Easily Annoyed/Irritable", "VISIT 12", 12, "2013-11-14", "Several days", - 31L, "GAD0207", "GAD02-Feel Afraid/Something Awful Happen", "VISIT 12", 12, "2013-11-14", "Several days", - 32L, "GAD0208", "GAD02-Total Score", "VISIT 12", 12, "2013-11-14", "7" - ) %>% - mutate( - QSCAT = "GAD-7 V2", - QSSTRESN = recode( - QSORRES, - "Not at all" = 0L, - "Several days" = 1L, - "More than half the days" = 2L, - "Nearly every day" = 3L, - .default = as.integer(QSORRES) - ) - ) %>% - mutate( - USUBJID = "P0001", - .before = everything() - ), - regexpr = "NAs introduced by coercion" -) -qs_gdssf <- tibble::tribble( - ~USUBJID, ~QSSEQ, ~QSTEST, ~QSTESTCD, ~VISIT, ~VISITNUM, ~QSDTC, ~QSORRES, ~QSSTRESN, - "P0001", 1L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 1", 1, "2012-11-16", "YES", 0L, - "P0001", 2L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 3L, "GDS02-Life Is Empty", "GDS0203", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0001", 4L, "GDS02-Bored Often", "GDS0204", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 5L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 1", 1, "2012-11-16", "NO", 1L, - "P0001", 6L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 7L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 1", 1, "2012-11-16", "NO", 1L, - "P0001", 8L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 9L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0001", 10L, "GDS02-Memory Problems", "GDS0210", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 11L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 1", 1, "2012-11-16", "NO", 1L, - "P0001", 12L, "GDS02-Feel Worthless", "GDS0212", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 13L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 1", 1, "2012-11-16", "YES", 0L, - "P0001", 14L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", 15L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0001", 16L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 2", 2, "2012-12-15", "YES", 0L, - "P0001", 17L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", 18L, "GDS02-Life Is Empty", "GDS0203", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", 19L, "GDS02-Bored Often", "GDS0204", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0001", 20L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 2", 2, "2012-12-15", "NO", 1L, - "P0001", 21L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0001", 22L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 2", 2, "2012-12-15", "NO", 1L, - "P0001", 23L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0001", 24L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", 25L, "GDS02-Memory Problems", "GDS0210", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", 26L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 2", 2, "2012-12-15", "NO", 1L, - "P0001", 27L, "GDS02-Feel Worthless", "GDS0212", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0001", 28L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 2", 2, "2012-12-15", "YES", 0L, - "P0001", 29L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0001", 30L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", 31L, "GDS02-Satisfied With Life", "GDS0201", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 0L, - "P0001", 32L, "GDS02-Dropped Activities and Interests", "GDS0202", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, - "P0001", 33L, "GDS02-Life Is Empty", "GDS0203", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, - "P0001", 34L, "GDS02-Bored Often", "GDS0204", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, - "P0001", 35L, "GDS02-Good Spirits Most of Time", "GDS0205", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 1L, - "P0001", 36L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, - "P0001", 37L, "GDS02-Feel Happy Most of Time", "GDS0207", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, - "P0001", 38L, "GDS02-Often Feel Helpless", "GDS0208", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, - "P0001", 39L, "GDS02-Prefer to Stay Home", "GDS0209", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, - "P0001", 40L, "GDS02-Memory Problems", "GDS0210", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, - "P0001", 41L, "GDS02-Wonderful to Be Alive", "GDS0211", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 1L, - "P0001", 42L, "GDS02-Feel Worthless", "GDS0212", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, - "P0001", 43L, "GDS02-Feel Full of Energy", "GDS0213", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 0L, - "P0001", 44L, "GDS02-Feel Hopeless", "GDS0214", "UNSCHEDULED 2.01", 201, "2012-12-28", "YES", 1L, - "P0001", 45L, "GDS02-Most People Better Off Than You", "GDS0215", "UNSCHEDULED 2.01", 201, "2012-12-28", "NO", 0L, - "P0001", 46L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 3", 3, "2013-01-12", NA, NA, - "P0001", 47L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 3", 3, "2013-01-12", NA, NA, - "P0001", 48L, "GDS02-Life Is Empty", "GDS0203", "VISIT 3", 3, "2013-01-12", "NO", 0L, - "P0001", 49L, "GDS02-Bored Often", "GDS0204", "VISIT 3", 3, "2013-01-12", "NO", 0L, - "P0001", 50L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 3", 3, "2013-01-12", "YES", 0L, - "P0001", 51L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 3", 3, "2013-01-12", "YES", 1L, - "P0001", 52L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 3", 3, "2013-01-12", "NO", 1L, - "P0001", 53L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 3", 3, "2013-01-12", "YES", 1L, - "P0001", 54L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 3", 3, "2013-01-12", "NO", 0L, - "P0001", 55L, "GDS02-Memory Problems", "GDS0210", "VISIT 3", 3, "2013-01-12", "NO", 0L, - "P0001", 56L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 3", 3, "2013-01-12", "NO", 1L, - "P0001", 57L, "GDS02-Feel Worthless", "GDS0212", "VISIT 3", 3, "2013-01-12", "YES", 1L, - "P0001", 58L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 3", 3, "2013-01-12", "YES", 0L, - "P0001", 59L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 3", 3, "2013-01-12", "YES", 1L, - "P0001", 60L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 3", 3, "2013-01-12", "NO", 0L, - "P0001", 61L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 4", 4, "2013-02-13", "YES", 0L, - "P0001", 62L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 63L, "GDS02-Life Is Empty", "GDS0203", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 64L, "GDS02-Bored Often", "GDS0204", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 65L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 4", 4, "2013-02-13", "YES", 0L, - "P0001", 66L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0001", 67L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0001", 68L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 69L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 70L, "GDS02-Memory Problems", "GDS0210", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 71L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0001", 72L, "GDS02-Feel Worthless", "GDS0212", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 73L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 4", 4, "2013-02-13", "YES", 0L, - "P0001", 74L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", 75L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0002", 1L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 1", 1, "2012-11-16", "YES", 0L, - "P0002", 2L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0002", 3L, "GDS02-Life Is Empty", "GDS0203", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 4L, "GDS02-Bored Often", "GDS0204", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0002", 5L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 1", 1, "2012-11-16", "NO", 1L, - "P0002", 6L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 7L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 1", 1, "2012-11-16", "NO", 1L, - "P0002", 8L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 9L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 10L, "GDS02-Memory Problems", "GDS0210", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 11L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 1", 1, "2012-11-16", "YES", 0L, - "P0002", 12L, "GDS02-Feel Worthless", "GDS0212", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 13L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 1", 1, "2012-11-16", "YES", 0L, - "P0002", 14L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 15L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0002", 16L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 2", 2, "2012-12-15", "YES", 0L, - "P0002", 17L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0002", 18L, "GDS02-Life Is Empty", "GDS0203", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0002", 19L, "GDS02-Bored Often", "GDS0204", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0002", 20L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 2", 2, "2012-12-15", "NO", 1L, - "P0002", 21L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0002", 22L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 2", 2, "2012-12-15", "NO", 1L, - "P0002", 23L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0002", 24L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 2", 2, "2012-12-15", "YES", 1L, - "P0002", 25L, "GDS02-Memory Problems", "GDS0210", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0002", 26L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 2", 2, "2012-12-15", "YES", 0L, - "P0002", 27L, "GDS02-Feel Worthless", "GDS0212", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0002", 28L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 2", 2, "2012-12-15", "YES", 0L, - "P0002", 29L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0002", 30L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0002", 46L, "GDS02-Satisfied With Life", "GDS0201", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0002", 47L, "GDS02-Dropped Activities and Interests", "GDS0202", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 48L, "GDS02-Life Is Empty", "GDS0203", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0002", 49L, "GDS02-Bored Often", "GDS0204", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 50L, "GDS02-Good Spirits Most of Time", "GDS0205", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0002", 51L, "GDS02-Afraid of Something Bad Happening", "GDS0206", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 52L, "GDS02-Feel Happy Most of Time", "GDS0207", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0002", 53L, "GDS02-Often Feel Helpless", "GDS0208", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 54L, "GDS02-Prefer to Stay Home", "GDS0209", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 55L, "GDS02-Memory Problems", "GDS0210", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 56L, "GDS02-Wonderful to Be Alive", "GDS0211", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0002", 57L, "GDS02-Feel Worthless", "GDS0212", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 58L, "GDS02-Feel Full of Energy", "GDS0213", "VISIT 4", 4, "2013-02-13", "NO", 1L, - "P0002", 59L, "GDS02-Feel Hopeless", "GDS0214", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0002", 60L, "GDS02-Most People Better Off Than You", "GDS0215", "VISIT 4", 4, "2013-02-13", "NO", 0L -) %>% - mutate(QSCAT = "GDS SHORT FORM") - -qs_sp <- tibble::tribble( - ~USUBJID, ~QSTEST, ~QSTESTCD, ~VISIT, ~VISITNUM, ~QSDTC, ~QSORRES, ~QSSTRESN, - "P0001", "SP01-No sleep at all", "SP0101", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0001", "SP01-Waking up more than three times", "SP0102", "VISIT 1", 1, "2012-11-16", "NO", 0L, - "P0001", "SP01-More than 30 mins to fall asleep", "SP0103", "VISIT 1", 1, "2012-11-16", "YES", 1L, - "P0001", "SP01-No sleep at all", "SP0101", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", "SP01-Waking up more than three times", "SP0102", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", "SP01-More than 30 mins to fall asleep", "SP0103", "VISIT 2", 2, "2012-12-15", "NO", 0L, - "P0001", "SP01-No sleep at all", "SP0101", "VISIT 4", 4, "2013-02-13", "NO", 0L, - "P0001", "SP01-Waking up more than three times", "SP0102", "VISIT 4", 4, "2013-02-13", "YES", 1L, - "P0001", "SP01-More than 30 mins to fall asleep", "SP0103", "VISIT 4", 4, "2013-02-13", "YES", 1L, -) %>% - mutate( - QSSEQ = row_number(), - QSCAT = "SLEEPING PROBLEMS", - .after = USUBJID - ) - -# nolint end -example_qs <- bind_rows(qs_gad7, qs_gdssf, qs_sp) %>% - mutate( - STUDYID = "STUDYX", - .before = everything() - ) - -save(example_qs, file = file.path("data", "example_qs.rda"), compress = "bzip2") From 26e9313c23eb7e7205fdf8a2d695d03c607a3cd1 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Wed, 4 Sep 2024 15:58:15 -0700 Subject: [PATCH 16/31] Issue #2427 Code for atoxgr*.rda move to data-raw/ --- data-raw/adlb_grading/adlb_grading_spec.xlsx | Bin 0 -> 192638 bytes data-raw/adlb_grading/atoxgr_sources.R | 22 +++++++++++++++++++ data-raw/derive_single_dose.R | 5 +---- data/atoxgr_criteria_ctcv4.rda | Bin 34326 -> 4405 bytes data/atoxgr_criteria_ctcv5.rda | Bin 37141 -> 4391 bytes data/atoxgr_criteria_daids.rda | Bin 42964 -> 5114 bytes 6 files changed, 23 insertions(+), 4 deletions(-) create mode 100644 data-raw/adlb_grading/adlb_grading_spec.xlsx 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This way we +# avoid having to list {readxl} in "Imports" and instead get away with just +# listing it in "Depends". + +atoxgr_criteria_ctcv4 <- atoxgr_criteria %>% + readxl::read_excel(sheet = "NCICTCAEv4") %>% + dplyr::mutate(GRADE_CRITERIA_CODE = gsub("[\r\n]", " ", GRADE_CRITERIA_CODE)) + +usethis::use_data(atoxgr_criteria_ctcv4, overwrite = TRUE) + +atoxgr_criteria_ctcv5 <- atoxgr_criteria %>% + readxl::read_excel(sheet = "NCICTCAEv5") %>% + dplyr::mutate(GRADE_CRITERIA_CODE = gsub("[\r\n]", " ", GRADE_CRITERIA_CODE)) + +use_data(atoxgr_criteria_ctcv5, overwrite = TRUE) + +atoxgr_criteria_daids <- atoxgr_criteria %>% + readxl::read_excel(sheet = "DAIDS") %>% + dplyr::mutate(GRADE_CRITERIA_CODE = gsub("[\r\n]", " ", GRADE_CRITERIA_CODE)) + +use_data(atoxgr_criteria_daids, overwrite = TRUE) diff --git a/data-raw/derive_single_dose.R b/data-raw/derive_single_dose.R index 6ceace95a9..595ac6a769 100644 --- a/data-raw/derive_single_dose.R +++ b/data-raw/derive_single_dose.R @@ -1,6 +1,3 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z_4{|%zm)VBzFOP12kvZa-(BC?c(^4gUSEIs;KALkolM5E$Axa^8+>?A*klqmIrAO< w?}s0L_{Rw0YqeIjrwn&i3Eh9%+O6-&UuW@4{&^AK3asY#x?l`;|4aY Date: Wed, 4 Sep 2024 16:18:19 -0700 Subject: [PATCH 17/31] Remove unnecessary comment. --- data-raw/derive_single_dose.R | 1 - 1 file changed, 1 deletion(-) diff --git a/data-raw/derive_single_dose.R b/data-raw/derive_single_dose.R index 595ac6a769..7a7342d933 100644 --- a/data-raw/derive_single_dose.R +++ b/data-raw/derive_single_dose.R @@ -50,5 +50,4 @@ attr(ex_single$EXSTDTC, "label") <- attr(ex$EXSTDTC, "label") attr(ex_single$EXENDTC, "label") <- attr(ex$EXENDTC, "label") attr(ex_single$EXDOSFRQ, "label") <- attr(ex$EXDOSFRQ, "label") -# save(ex_single, file = file.path("data", "ex_single.rda"), compress = "bzip2") usethis::use_data(ex_single, overwrite = TRUE) From aeaed83306be88a2a50854fd0df479d5a9381bd9 Mon Sep 17 00:00:00 2001 From: jimrothstein Date: Thu, 5 Sep 2024 16:16:58 -0700 Subject: [PATCH 18/31] EXPERIMENT: Is newly created dataset data/admiral_adlb.rda identical to backup? NO --- data-raw/admiral_adlb.R | 471 +++++++++++++++++++++++++++++++++ data-raw/create_admiral_adlb.R | 18 ++ data/admiral_adlb.rda | Bin 110433 -> 1233575 bytes 3 files changed, 489 insertions(+) create mode 100644 data-raw/admiral_adlb.R create mode 100644 data-raw/create_admiral_adlb.R diff --git a/data-raw/admiral_adlb.R b/data-raw/admiral_adlb.R new file mode 100644 index 0000000000..f3eecd1ca7 --- /dev/null +++ b/data-raw/admiral_adlb.R @@ -0,0 +1,471 @@ +# Name: ADLB +# +# Label: Lab Analysis Dataset +# +# Input: adsl, lb +library(admiral) +library(pharmaversesdtm) # Contains example datasets from the CDISC pilot project +library(dplyr) +library(lubridate) +library(stringr) + +# Load source datasets ---- + +# Use e.g. haven::read_sas to read in .sas7bdat, or other suitable functions +# as needed and assign to the variables below. +# For illustration purposes read in admiral test data + +data("lb") +data("admiral_adsl") + +adsl <- admiral_adsl + +# When SAS datasets are imported into R using haven::read_sas(), missing +# character values from SAS appear as "" characters in R, instead of appearing +# as NA values. Further details can be obtained via the following link: +# https://pharmaverse.github.io/admiral/articles/admiral.html#handling-of-missing-values # nolint + +lb <- convert_blanks_to_na(lb) + +# Look-up tables ---- + +# Assign PARAMCD, PARAM, and PARAMN +param_lookup <- tibble::tribble( + ~LBTESTCD, ~PARAMCD, ~PARAM, ~PARAMN, + "ALB", "ALB", "Albumin (g/L)", 1, + "ALP", "ALKPH", "Alkaline Phosphatase (U/L)", 2, + "ALT", "ALT", "Alanine Aminotransferase (U/L)", 3, + "ANISO", "ANISO", "Anisocytes", 4, + "AST", "AST", "Aspartate Aminotransferase (U/L)", 5, + "BASO", "BASO", "Basophils Abs (10^9/L)", 6, + "BASOLE", "BASOLE", "Basophils/Leukocytes (FRACTION)", 7, + "BILI", "BILI", "Bilirubin (umol/L)", 8, + "BUN", "BUN", "Blood Urea Nitrogen (mmol/L)", 9, + "CA", "CA", "Calcium (mmol/L)", 10, + "CHOL", "CHOLES", "Cholesterol (mmol/L)", 11, + "CK", "CK", "Creatinine Kinase (U/L)", 12, + "CL", "CL", "Chloride (mmol/L)", 13, + "COLOR", "COLOR", "Color", 14, + "CREAT", "CREAT", "Creatinine (umol/L)", 15, + "EOS", "EOS", "Eosinophils (10^9/L)", 16, + "EOSLE", "EOSLE", "Eosinophils/Leukocytes (FRACTION)", 17, + "GGT", "GGT", "Gamma Glutamyl Transferase (U/L)", 18, + "GLUC", "GLUC", "Glucose (mmol/L)", 19, + "HBA1C", "HBA1C", "Hemoglobin A1C (1)", 20, + "HCT", "HCT", "Hematocrit (1)", 21, + "HGB", "HGB", "Hemoglobin (mmol/L)", 22, + "K", "POTAS", "Potassium (mmol/L)", 23, + "KETONES", "KETON", "Ketones", 24, + "LYM", "LYMPH", "Lymphocytes Abs (10^9/L)", 25, + "LYMLE", "LYMPHLE", "Lymphocytes/Leukocytes (FRACTION)", 26, + "MACROCY", "MACROC", "Macrocytes", 27, + "MCH", "MCH", "Ery. Mean Corpuscular Hemoglobin (fmol(Fe))", 28, + "MCHC", "MCHC", "Ery. Mean Corpuscular HGB Concentration (mmol/L)", 29, + "MCV", "MCV", "Ery. Mean Corpuscular Volume (f/L)", 30, + "MICROCY", "MICROC", "Microcytes", 31, + "MONO", "MONO", "Monocytes (10^9/L)", 32, + "MONOLE", "MONOLE", "Monocytes/Leukocytes (FRACTION)", 33, + "PH", "PH", "pH", 34, + "PHOS", "PHOS", "Phosphate (mmol/L)", 35, + "PLAT", "PLAT", "Platelet (10^9/L)", 36, + "POIKILO", "POIKIL", "Poikilocytes", 37, + "POLYCHR", "POLYCH", "Polychromasia", 38, + "PROT", "PROT", "Protein (g/L)", 39, + "RBC", "RBC", "Erythrocytes (TI/L)", 40, + "SODIUM", "SODIUM", "Sodium (mmol/L)", 41, + "SPGRAV", "SPGRAV", "Specific Gravity", 42, + "TSH", "TSH", "Thyrotropin (mU/L)", 43, + "URATE", "URATE", "Urate (umol/L)", 44, + "UROBIL", "UROBIL", "Urobilinogen", 45, + "VITB12", "VITB12", "Vitamin B12 (pmol/L)", 46, + "WBC", "WBC", "Leukocytes (10^9/L)", 47 +) + + +# Derivations ---- + +# Get list of ADSL vars required for derivations +adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P) + +adlb <- lb %>% + # Join ADSL with LB (need TRTSDT for ADY derivation) + derive_vars_merged( + dataset_add = adsl, + new_vars = adsl_vars, + by_vars = exprs(STUDYID, USUBJID) + ) %>% + ## Calculate ADT, ADY ---- + derive_vars_dt( + new_vars_prefix = "A", + dtc = LBDTC + ) %>% + derive_vars_dy(reference_date = TRTSDT, source_vars = exprs(ADT)) + +adlb <- adlb %>% + ## Add PARAMCD PARAM and PARAMN - from LOOK-UP table ---- + # Replace with PARAMCD lookup function + derive_vars_merged_lookup( + dataset_add = param_lookup, + new_vars = exprs(PARAMCD, PARAM, PARAMN), + by_vars = exprs(LBTESTCD), + check_type = "none", + print_not_mapped = FALSE + ) %>% + ## Calculate PARCAT1 AVAL AVALC ANRLO ANRHI ---- + mutate( + PARCAT1 = LBCAT, + AVAL = LBSTRESN, + # Only populate AVALC if character value is non-redundant with AVAL + AVALC = ifelse( + is.na(LBSTRESN) | as.character(LBSTRESN) != LBSTRESC, + LBSTRESC, + NA + ), + ANRLO = LBSTNRLO, + ANRHI = LBSTNRHI + ) + +# Derive Absolute values from fractional Differentials using WBC +# Only derive where absolute values do not already exist +# Need to populate ANRLO and ANRHI for newly created records +adlb <- adlb %>% + # Derive absolute Basophils + derive_param_wbc_abs( + by_vars = exprs(STUDYID, USUBJID, !!!adsl_vars, DOMAIN, VISIT, VISITNUM, ADT, ADY), + set_values_to = exprs( + PARAMCD = "BASO", + PARAM = "Basophils Abs (10^9/L)", + PARAMN = 6, + DTYPE = "CALCULATION", + PARCAT1 = "HEMATOLOGY" + ), + get_unit_expr = extract_unit(PARAM), + diff_code = "BASOLE" + ) %>% + # Derive absolute Lymphocytes + derive_param_wbc_abs( + by_vars = exprs(STUDYID, USUBJID, !!!adsl_vars, DOMAIN, VISIT, VISITNUM, ADT, ADY), + set_values_to = exprs( + PARAMCD = "LYMPH", + PARAM = "Lymphocytes Abs (10^9/L)", + PARAMN = 25, + DTYPE = "CALCULATION", + PARCAT1 = "HEMATOLOGY" + ), + get_unit_expr = extract_unit(PARAM), + diff_code = "LYMPHLE" + ) + +## Get Visit Info ---- +# See also the "Visit and Period Variables" vignette +# (https://pharmaverse.github.io/admiral/articles/visits_periods.html#visits) +adlb <- adlb %>% + # Derive Timing + mutate( + AVISIT = case_when( + str_detect(VISIT, "SCREEN") ~ "Baseline", + !is.na(VISIT) ~ str_to_title(VISIT), + TRUE ~ NA_character_ + ), + AVISITN = case_when( + AVISIT == "Baseline" ~ 0, + !is.na(VISITNUM) ~ VISITNUM + ) + ) + +adlb <- adlb %>% + ## Calculate ONTRTFL ---- + derive_var_ontrtfl( + start_date = ADT, + ref_start_date = TRTSDT, + ref_end_date = TRTEDT, + filter_pre_timepoint = AVISIT == "Baseline" + ) + +## Calculate ANRIND : requires the reference ranges ANRLO, ANRHI ---- +adlb <- adlb %>% + derive_var_anrind() + +## Derive baseline flags ---- +adlb <- adlb %>% + # Calculate BASETYPE + mutate( + BASETYPE = "LAST" + ) %>% + # Calculate ABLFL + restrict_derivation( + derivation = derive_var_extreme_flag, + args = params( + by_vars = exprs(STUDYID, USUBJID, BASETYPE, PARAMCD), + order = exprs(ADT, VISITNUM, LBSEQ), + new_var = ABLFL, + mode = "last" + ), + filter = (!is.na(AVAL) & ADT <= TRTSDT & !is.na(BASETYPE)) + ) + +## Derive baseline information ---- +adlb <- adlb %>% + # Calculate BASE + derive_var_base( + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + source_var = AVAL, + new_var = BASE + ) %>% + # Calculate BASEC + derive_var_base( + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + source_var = AVALC, + new_var = BASEC + ) %>% + # Calculate BNRIND + derive_var_base( + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + source_var = ANRIND, + new_var = BNRIND + ) %>% + # Calculate CHG + derive_var_chg() %>% + # Calculate PCHG + derive_var_pchg() + + +## Calculate lab grading ---- + +# Assign ATOXDSCL and ATOXDSCH to hold lab grading terms +# ATOXDSCL and ATOXDSCH hold terms defined by NCI-CTCAEv4. +# See (https://pharmaverse.github.io/admiral/articles/lab_grading.html#implement_ctcv4) +grade_lookup <- tibble::tribble( + ~PARAMCD, ~ATOXDSCL, ~ATOXDSCH, + "ALB", "Hypoalbuminemia", NA_character_, + "ALKPH", NA_character_, "Alkaline phosphatase increased", + "ALT", NA_character_, "Alanine aminotransferase increased", + "AST", NA_character_, "Aspartate aminotransferase increased", + "BILI", NA_character_, "Blood bilirubin increased", + "CA", "Hypocalcemia", "Hypercalcemia", + "CHOLES", NA_character_, "Cholesterol high", + "CK", NA_character_, "CPK increased", + "CREAT", NA_character_, "Creatinine increased", + "GGT", NA_character_, "GGT increased", + "GLUC", "Hypoglycemia", "Hyperglycemia", + "HGB", "Anemia", "Hemoglobin increased", + "POTAS", "Hypokalemia", "Hyperkalemia", + "LYMPH", "CD4 lymphocytes decreased", NA_character_, + "PHOS", "Hypophosphatemia", NA_character_, + "PLAT", "Platelet count decreased", NA_character_, + "SODIUM", "Hyponatremia", "Hypernatremia", + "WBC", "White blood cell decreased", "Leukocytosis", +) + +# Assign grade criteria +# metadata atoxgr_criteria_ctcv4 used to implement NCI-CTCAEv4 +# user could change to atoxgr_criteria_ctcv5 to implement NCI-CTCAEv5 +# Note: Hyperglycemia and Hypophosphatemia not defined in NCI-CTCAEv5 so +# user would need to amend look-up table grade_lookup +# See (https://pharmaverse.github.io/admiral/articles/lab_grading.html#implement_ctcv5) +grade_crit <- atoxgr_criteria_ctcv4 + + +# Add ATOXDSCL and ATOXDSCH +adlb <- adlb %>% + derive_vars_merged( + dataset_add = grade_lookup, + by_vars = exprs(PARAMCD) + ) %>% + # Derive toxicity grade for low values ATOXGRL + + derive_var_atoxgr_dir( + meta_criteria = grade_crit, + new_var = ATOXGRL, + tox_description_var = ATOXDSCL, + criteria_direction = "L", + get_unit_expr = extract_unit(PARAM) + ) %>% + # Derive toxicity grade for low values ATOXGRH + # default metadata atoxgr_criteria_ctcv4 used + derive_var_atoxgr_dir( + meta_criteria = grade_crit, + new_var = ATOXGRH, + tox_description_var = ATOXDSCH, + criteria_direction = "H", + get_unit_expr = extract_unit(PARAM) + ) %>% + # (Optional) derive overall grade ATOXGR (combining ATOXGRL and ATOXGRH) + derive_var_atoxgr() %>% + # Derive baseline toxicity grade for low values BTOXGRL + derive_var_base( + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + source_var = ATOXGRL, + new_var = BTOXGRL + ) %>% + # Derive baseline toxicity grade for high values BTOXGRH + derive_var_base( + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + source_var = ATOXGRH, + new_var = BTOXGRH + ) %>% + # Derive baseline toxicity grade for for overall grade BTOXGR + derive_var_base( + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + source_var = ATOXGR, + new_var = BTOXGR + ) + + +## Calculate R2BASE, R2ANRLO and R2ANRHI ---- +adlb <- adlb %>% + derive_var_analysis_ratio( + numer_var = AVAL, + denom_var = BASE + ) %>% + derive_var_analysis_ratio( + numer_var = AVAL, + denom_var = ANRLO + ) %>% + derive_var_analysis_ratio( + numer_var = AVAL, + denom_var = ANRHI + ) + +## SHIFT derivation ---- +adlb <- adlb %>% + # Derive shift from baseline for analysis indicator + derive_var_shift( + new_var = SHIFT1, + from_var = BNRIND, + to_var = ANRIND + ) %>% + # Derive shift from baseline for overall grade + restrict_derivation( + derivation = derive_var_shift, + args = params( + new_var = SHIFT2, + from_var = BTOXGR, + to_var = ATOXGR + ), + filter = !is.na(ATOXDSCL) | !is.na(ATOXDSCH) + ) + +## Flag variables (ANL01FL, LVOTFL) ---- +# ANL01FL: Flag last result within an AVISIT for post-baseline records +# LVOTFL: Flag last valid on-treatment record +adlb <- adlb %>% + restrict_derivation( + derivation = derive_var_extreme_flag, + args = params( + by_vars = exprs(USUBJID, PARAMCD, AVISIT), + order = exprs(ADT, AVAL), + new_var = ANL01FL, + mode = "last" + ), + filter = !is.na(AVISITN) & ONTRTFL == "Y" + ) %>% + restrict_derivation( + derivation = derive_var_extreme_flag, + args = params( + by_vars = exprs(USUBJID, PARAMCD), + order = exprs(ADT, AVAL), + new_var = LVOTFL, + mode = "last" + ), + filter = ONTRTFL == "Y" + ) + +## Get treatment information ---- +# See also the "Visit and Period Variables" vignette +# (https://pharmaverse.github.io/admiral/articles/visits_periods.html#treatment_bds) +adlb <- adlb %>% + # Assign TRTA, TRTP + mutate( + TRTP = TRT01P, + TRTA = TRT01A + ) + +## Get extreme values ---- +adlb <- adlb %>% + # get MINIMUM value + derive_extreme_records( + dataset_add = adlb, + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + order = exprs(AVAL, ADT, AVISITN), + mode = "first", + filter_add = (!is.na(AVAL) & ONTRTFL == "Y"), + set_values_to = exprs( + AVISITN = 9997, + AVISIT = "POST-BASELINE MINIMUM", + DTYPE = "MINIMUM" + ) + ) %>% + # get MAXIMUM value + derive_extreme_records( + dataset_add = adlb, + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + order = exprs(desc(AVAL), ADT, AVISITN), + mode = "first", + filter_add = (!is.na(AVAL) & ONTRTFL == "Y"), + set_values_to = exprs( + AVISITN = 9998, + AVISIT = "POST-BASELINE MAXIMUM", + DTYPE = "MAXIMUM" + ) + ) %>% + # get LOV value + derive_extreme_records( + dataset_add = adlb, + by_vars = exprs(STUDYID, USUBJID, PARAMCD, BASETYPE), + order = exprs(ADT, AVISITN), + mode = "last", + filter_add = (ONTRTFL == "Y"), + set_values_to = exprs( + AVISITN = 9999, + AVISIT = "POST-BASELINE LAST", + DTYPE = "LOV" + ) + ) + +## Get ASEQ ---- +adlb <- adlb %>% + # Calculate ASEQ + derive_var_obs_number( + new_var = ASEQ, + by_vars = exprs(STUDYID, USUBJID), + order = exprs(PARAMCD, ADT, AVISITN, VISITNUM), + check_type = "error" + ) + +# Add all ADSL variables +adlb <- adlb %>% + derive_vars_merged( + dataset_add = select(adsl, !!!negate_vars(adsl_vars)), + by_vars = exprs(STUDYID, USUBJID) + ) + +# Final Steps, Select final variables and Add labels +# This process will be based on your metadata, no example given for this reason +# ... + +# Save output ---- + +# Change to whichever directory you want to save the dataset in +#dir <- tools::R_user_dir("admiral_templates_data", which = "cache") +#if (!file.exists(dir)) { + # Create the folder +# dir.create(dir, recursive = TRUE, showWarnings = FALSE) +#} +#save(adlb, file = file.path(dir, "adlb.rda"), compress = "bzip2") + +admiral_adlb = adlb +use_data(admiral_adlb, overwrite=T) + + +# check - This dataset is identical to backup ? +e1 = new.env() +e2 = new.env() + +load("data/admiral_adlb.rda", e1) +load("data-backup/admiral_adlb.rda", e2) +e1$admiral_adlb +e2$admiral_adlb +identical(e1$admiral_adlb, e2$admiral_adlb) + + diff --git a/data-raw/create_admiral_adlb.R b/data-raw/create_admiral_adlb.R new file mode 100644 index 0000000000..d2e23ad6ba --- /dev/null +++ b/data-raw/create_admiral_adlb.R @@ -0,0 +1,18 @@ +# Create data/admiral_adlb.rda + +# This is a TWO-step process. + +library(admiral) + +# First, generate script from template +adam_name="adlb" +save_path = paste0("./data-raw/admiral_", adam_name, ".R") + +use_ad_template(adam_name = adam_name, + save_path = save_path, + open = F, + overwrite=T) + + +# Second, run the script (manually) + diff --git a/data/admiral_adlb.rda b/data/admiral_adlb.rda index 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