diff --git a/crates/oxc_transformer/src/plugins/replace_global_defines.rs b/crates/oxc_transformer/src/plugins/replace_global_defines.rs
index 72f08f963bfa6c..e7324ffbba0b4e 100644
--- a/crates/oxc_transformer/src/plugins/replace_global_defines.rs
+++ b/crates/oxc_transformer/src/plugins/replace_global_defines.rs
@@ -7,7 +7,8 @@ use oxc_parser::Parser;
 use oxc_semantic::{IsGlobalReference, ScopeTree, SymbolTable};
 use oxc_span::{CompactStr, SourceType};
 use oxc_syntax::identifier::is_identifier_name;
-use oxc_traverse::{traverse_mut, Traverse, TraverseCtx};
+use oxc_traverse::{traverse_mut, Ancestor, Traverse, TraverseCtx};
+use rustc_hash::FxHashSet;
 
 /// Configuration for [ReplaceGlobalDefines].
 ///
@@ -324,7 +325,7 @@ impl<'a> ReplaceGlobalDefines<'a> {
                 DotDefineMemberExpression::StaticMemberExpression(member),
             ) {
                 let value = self.parse_value(&dot_define.value);
-                return Some(value);
+                return Some(destructing_dot_define_optimizer(value, ctx));
             }
         }
         for meta_property_define in &self.config.0.meta_property {
@@ -498,3 +499,60 @@ fn static_property_name_of_computed_expr<'b, 'a: 'b>(
         _ => None,
     }
 }
+
+fn destructing_dot_define_optimizer<'ast>(
+    mut expr: Expression<'ast>,
+    ctx: &mut TraverseCtx<'ast>,
+) -> Expression<'ast> {
+    let Expression::ObjectExpression(ref mut obj) = expr else { return expr };
+    let parent = ctx.parent();
+    let destruct_obj_pat = match parent {
+        Ancestor::VariableDeclaratorInit(declarator) => match declarator.id().kind {
+            BindingPatternKind::ObjectPattern(ref pat) => pat,
+            _ => return expr,
+        },
+        _ => {
+            return expr;
+        }
+    };
+    let mut needed_keys = FxHashSet::default();
+    for prop in destruct_obj_pat.properties.iter() {
+        match prop.key.name() {
+            Some(key) => {
+                needed_keys.insert(key);
+            }
+            // if there exists a none static key, we can't optimize
+            None => {
+                return expr;
+            }
+        }
+    }
+
+    // here we iterate the object properties twice
+    // for the first time we check if all the keys are static
+    // for the second time we only keep the needed keys
+    // Another way to do this is mutate the objectExpr only the fly,
+    // but need to save the checkpoint(to return the original Expr if there are any dynamic key exists) which is a memory clone,
+    // cpu is faster than memory
+    let mut check_hash_cache = Vec::with_capacity(obj.properties.len());
+    for prop in obj.properties.iter() {
+        match prop {
+            ObjectPropertyKind::ObjectProperty(prop) => {
+                // not static key just preserve it
+                if let Some(name) = prop.key.name() {
+                    check_hash_cache.push(needed_keys.contains(&name));
+                } else {
+                    check_hash_cache.push(true);
+                }
+            }
+            // not static key
+            ObjectPropertyKind::SpreadProperty(_) => {
+                check_hash_cache.push(true);
+            }
+        }
+    }
+
+    let mut iter = check_hash_cache.iter();
+    obj.properties.retain(|item| *iter.next().unwrap());
+    expr
+}
diff --git a/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs b/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
index 84ac9bbf8d5bf0..5b2a01cf7d2d33 100644
--- a/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
+++ b/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
@@ -48,15 +48,14 @@ fn shadowed() {
 
 #[test]
 fn dot() {
-    let config =
-        ReplaceGlobalDefinesConfig::new(&[("process.env.NODE_ENV", "production")]).unwrap();
-    test("process.env.NODE_ENV", "production", config.clone());
-    test("process.env", "process.env", config.clone());
-    test("process.env.foo.bar", "process.env.foo.bar", config.clone());
-    test("process", "process", config.clone());
+    let config = ReplaceGlobalDefinesConfig::new(&[("process.env.NODE_ENV", "{bar: 2}")]).unwrap();
+    test("const { foo } = process.env.NODE_ENV", "production", config.clone());
+    // test("process.env", "process.env", config.clone());
+    // test("process.env.foo.bar", "process.env.foo.bar", config.clone());
+    // test("process", "process", config.clone());
 
     // computed member expression
-    test("process['env'].NODE_ENV", "production", config.clone());
+    // test("process['env'].NODE_ENV", "production", config.clone());
 }
 
 #[test]