diff --git a/lib/jsorolla b/lib/jsorolla
index 6b5c62588..fed62514e 160000
--- a/lib/jsorolla
+++ b/lib/jsorolla
@@ -1 +1 @@
-Subproject commit 6b5c625884d9c51c20b025a1897113a1f93fdadf
+Subproject commit fed62514e9686be7aa1a712b033b6d8eef305815
diff --git a/package.json b/package.json
index d0acaa53c..d425b461a 100644
--- a/package.json
+++ b/package.json
@@ -1,6 +1,6 @@
 {
   "name": "iva",
-  "version": "1.0.0-rc3",
+  "version": "1.0.0-rc4",
   "description": "IVA description",
   "repository": {
     "type": "git",
@@ -36,7 +36,7 @@
     "crypto-js": "~3.1.9-1",
     "eonasdan-bootstrap-datetimepicker": "~4.17.43",
     "file-saver": "~1.3.2",
-    "font-awesome": "*",
+    "@fortawesome/fontawesome-free": "^5.6.0",
     "highcharts": "~4.2.7",
     "jquery": "~2.2.4",
     "jquery.json-viewer": "^1.1.0",
diff --git a/src/conf/config.js b/src/conf/config.js
index d7cc3e177..7d4933da5 100644
--- a/src/conf/config.js
+++ b/src/conf/config.js
@@ -77,7 +77,7 @@ const opencga = {
 
 const application = {
     title: "IVA",
-    version: "v1.0.0-rc3",
+    version: "v1.0.0-rc4",
     logo: "img/opencb-logo.png",
     // The order, title and nested submenus are respected
     menu: [
@@ -91,6 +91,11 @@ const application = {
             title: "Aggregation Stats",
             visibility: "public",
         },
+        {
+            id: "clinicalAnalysisPortal",
+            title: "Interpretation Portal",
+            visibility: "public",
+        },
         {
             id: "beacon",
             title: "Beacon",
@@ -99,22 +104,8 @@ const application = {
         {
             id: "case",
             title: "Clinical",
-            visibility: "public",
+            visibility: "none",
             submenu: [
-                {
-                    id: "clinicalAnalysisPortal",
-                    title: "Interpretation Portal",
-                    visibility: "public",
-                },
-                {
-                    id: "interpretation",
-                    title: "Variant Interpreter",
-                    visibility: "public",
-                },
-                {
-                    separator: true,
-                    visibility: "public",
-                },
                 {
                     id: "clinical",
                     title: "Clinical (Old)",
@@ -124,7 +115,7 @@ const application = {
         },
         {
             id: "genomeBrowser",
-            title: "Genome Browser (Beta)",
+            title: "Genome Browser",
             visibility: "public"
         },
         {
@@ -185,9 +176,14 @@ const application = {
                     category: true,
                     visibility: "public",
                 },
+                {
+                    id: "interpretation",
+                    title: "Variant Interpreter",
+                    visibility: "public",
+                },
                 {
                     id: "tiering",
-                    title: "Tiering (Genomics England)",
+                    title: "OpenCGA Tiering (Based on GEL Tiering)",
                     visibility: "public",
                 },
                 {
@@ -223,7 +219,7 @@ const application = {
         },
         {
             id: "catalog",
-            title: "Catalog (New!)",
+            title: "Catalog Metadata",
             visibility: "public",
             submenu: [
                 {
@@ -283,7 +279,7 @@ const application = {
         visible: true,
     },
     settings: {
-        visibility: "public",
+        visible: false,
     },
     about: {
         dropdown: true,
@@ -367,12 +363,16 @@ const populationFrequencies = {
         common: "#0000ff",
         unobserved: "black"
     },
+    tooltip: `<strong>1000 Genomes</strong> Only considers variants whose observed allelic frequency in the 1000 genomes phase 3 database 
+                is below (or above) the defined value. Genome-wide allelic frequencies were obtained from more than 2.500 genomes.<br><br>
+              <strong>gnomAD Genomes</strong> Only considers variants whose observed allelic frequency in the gnomAD Genomes database is 
+                below (or above) the defined value. Frequencies were calculated from about 15,000 unrelated individuals`,
     studies: [
         {
             id: "1kG_phase3",
             title: "1000 Genomes",
-            tooltip: "Only considers variants whose observed allelic frequency in the 1000 genomes phase 3 database is below (or above) " +
-                "the defined value. Genome-wide allelic frequencies were obtained from more than 2.500 genomes.",
+            // tooltip: "Only considers variants whose observed allelic frequency in the 1000 genomes phase 3 database is below (or above) " +
+            //     "the defined value. Genome-wide allelic frequencies were obtained from more than 2.500 genomes.",
             populations: [
                 {
                     id: "ALL", title: "All populations [ALL]",
@@ -397,8 +397,8 @@ const populationFrequencies = {
         {
             id: "GNOMAD_GENOMES",
             title: "gnomAD Genomes",
-            tooltip: "Only considers variants whose observed allelic frequency in the gnomAD Genomes database is below (or above) the " +
-                "defined value. Frequencies were calculated from about 15,000 unrelated individuals.",
+            // tooltip: "Only considers variants whose observed allelic frequency in the gnomAD Genomes database is below (or above) the " +
+            //     "defined value. Frequencies were calculated from about 15,000 unrelated individuals.",
             populations: [
                 {
                     id: "ALL", title: "gnomAD [ALL]",
diff --git a/src/conf/tools.js b/src/conf/tools.js
index c90f5edc2..ddab97209 100644
--- a/src/conf/tools.js
+++ b/src/conf/tools.js
@@ -17,6 +17,7 @@
 /**
  * Created by imedina on 05/06/17.
  */
+
 const filterMenu = {
     searchButtonText: "Search",
     tooltip: {
@@ -77,7 +78,7 @@ const filterMenu = {
                 },
                 {
                     id: "biotype",
-                    title: "Biotype",
+                    title: "Gene Biotype",
                     biotypes: [
                         "3prime_overlapping_ncrna", "IG_C_gene", "IG_C_pseudogene", "IG_D_gene", "IG_J_gene", "IG_J_pseudogene",
                         "IG_V_gene", "IG_V_pseudogene", "Mt_rRNA", "Mt_tRNA", "TR_C_gene", "TR_D_gene", "TR_J_gene", "TR_J_pseudogene",
@@ -104,13 +105,8 @@ const filterMenu = {
                 {
                     id: "populationFrequency",
                     title: "Select Population Frequency",
-                    tooltip: "<strong>1000 Genomes</strong> only considers variants whose observed allelic frequency in the 1000 Genomes " +
-                    "Phase 3 project is below (or above) the defined value. Allele frequencies were obtained from about 2,500 samples." +
-                    "<br><strong>ExAC</strong> only considers variants whose observed allelic frequency in the The Exome Aggregation " +
-                    "Consortium (ExAC) database is below (or above) the defined value. ExAC covers only exomic positions. " +
-                    "The frequencies were obtained using more than 60.000 exomes." +
-                    "<br><strong>ESP56500</strong> only considers variants whose observed allelic frequency in the Exome Variant Server " +
-                    "(ESP6500) database is below (or above) the defined value. ESP6500 covers only exomic positions from about 6000 exomes"
+                    tooltip: populationFrequencies.tooltip,
+                    showSetAll: true
                 }
             ]
         },
@@ -247,7 +243,7 @@ const tools = {
             examples: [
                 {
                     name: "Example BRCA2",
-                    active: true,
+                    active: false,
                     query: {
                         gene: "BRCA2",
                         conservation: "phylop<0.001"
@@ -304,13 +300,13 @@ const tools = {
             {
                 id: "network",
                 component: "reactome-variant-network",
-                title: "Gene network"
+                title: "Reactome Pathways"
             },
-            {
-                id: "template",
-                component: "opencga-variant-detail-template",
-                title: "Template"
-            }
+            // {
+            //     id: "template",
+            //     component: "opencga-variant-detail-template",
+            //     title: "Template"
+            // }
         ]
     },
     interpretation: {
@@ -318,7 +314,20 @@ const tools = {
         active: false,
         filter: {
             menu: interpreterMenu,
+            lof: ["transcript_ablation", "splice_acceptor_variant", "splice_donor_variant", "stop_gained", "frameshift_variant",
+                "stop_lost", "start_lost", "transcript_amplification", "inframe_insertion", "inframe_deletion"],
             examples: [
+                {
+                    name: "Default (protein and missense)",
+                    active: true,
+                    query: {
+                        biotype: "protein_coding",
+                        // alternate_frequency: "1kG_phase3:ALL<0.001;GNOMAD_GENOMES:ALL<0.001",
+                        ct: "transcript_ablation,splice_acceptor_variant,splice_donor_variant,stop_gained," +
+                            "frameshift_variant,stop_lost,start_lost,transcript_amplification,inframe_insertion,inframe_deletion," +
+                            "missense_variant",
+                    }
+                },
                 {
                     name: "Tiering (AR)",
                     active: false,
@@ -345,19 +354,6 @@ const tools = {
                             "SO:0001821,SO:0001822,SO:0001583,SO:0001630,SO:0001626"
                     }
                 },
-                {
-                    name: "Clinical Interpretation",
-                    active: true,
-                    query: {
-                        region: "1",
-                        biotype: "protein_coding",
-                        alternate_frequency: "1kG_phase3:ALL<0.001;GNOMAD_GENOMES:ALL<0.001",
-                        ct: "transcript_ablation,splice_acceptor_variant,splice_donor_variant,stop_gained," +
-                            "frameshift_variant,stop_lost,start_lost,transcript_amplification,inframe_insertion,inframe_deletion," +
-                            "missense_variant",
-                        // genotype: "NA12877:0/1;NA12878:0/1;NA12879:0/1,1/1"
-                    }
-                },
                 {
                     name: "Stickler syndrome",
                     query: {
@@ -403,11 +399,11 @@ const tools = {
                 //     "lovd", "hgmd", "icgc", "sahgp"
                 // ]
             },
-            {
-                id: "template",
-                component: "opencga-variant-detail-template",
-                title: "Template"
-            }
+            // {
+            //     id: "template",
+            //     component: "opencga-variant-detail-template",
+            //     title: "Template"
+            // }
         ],
         css: {
             style: "font-size: 12px"
diff --git a/src/index.html b/src/index.html
index fea6f19cb..07ffc1f39 100644
--- a/src/index.html
+++ b/src/index.html
@@ -85,7 +85,8 @@
     <!-- /build -->
 
     <!-- build:css css/font-awesome.min.css -->
-    <link rel="stylesheet" href="../node_modules/font-awesome/css/font-awesome.min.css">
+    <!--<link rel="stylesheet" href="../node_modules/font-awesome/css/font-awesome.min.css">-->
+    <link rel="stylesheet" href="../node_modules/@fortawesome/fontawesome-free/css/all.min.css">
     <!-- /build -->
 
     <!-- build:css css/jquery.qtip.min.css -->
diff --git a/src/iva-app.html b/src/iva-app.html
index b35800c15..777d48ead 100644
--- a/src/iva-app.html
+++ b/src/iva-app.html
@@ -40,13 +40,13 @@
 <link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/family/opencga-family-browser.html">
 <link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/cohorts/opencga-cohort-browser.html">
 <link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/panel/opencga-panel-browser.html">
-<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/clinical/opencga-clinical-portal.html">
-<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/clinical/opencga-clinical-analysis-browser.html">
-<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/clinical/opencga-clinical-analysis-portal.html">
-<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/catalog/clinical/opencga-clinical-analysis-editor.html">
+<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/opencga-clinical-portal.html">
+<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/opencga-clinical-analysis-browser.html">
+<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/opencga-clinical-review-cases.html">
+<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/opencga-clinical-analysis-editor.html">
 
 <link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/clinical-interpretation-view.html">
-<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/opencga-variant-clinical.html">
+<link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/clinical/obsolete/opencga-variant-clinical.html">
 
 <link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/variant/opencga-variant-browser.html">
 <link rel="import" href="../lib/jsorolla/src/core/webcomponents/opencga/variant/opencga-variant-interpretation.html">
@@ -82,8 +82,8 @@
         </custom-style>
 
         <div>
-            <div style="height: 60px;">
-                <nav class="navbar navbar-inverse navbar-fixed-top">
+            <div>
+                <nav class="navbar navbar-inverse" style="margin-bottom: 5px; border-radius: 0px">
                     <div class="container-fluid">
 
                         <!-- Brand and toggle get grouped for better mobile display -->
@@ -168,10 +168,12 @@
                                             <!--<li>-->
                                             <!--<a data-target="#jobModal" data-toggle="modal"><i class="fa fa-bars" aria-hidden="true"></i> Jobs</a>-->
                                             <!--</li>-->
-                                            <li role="separator" class="divider"></li>
-                                            <li>
-                                                <a href="#settings"><i class="fa fa-cog" aria-hidden="true"></i> Settings</a>
-                                            </li>
+                                            <template is="dom-if" if="{{config.settings.visible}}">
+                                                <li role="separator" class="divider"></li>
+                                                <li>
+                                                    <a href="#settings"><i class="fa fa-cog" aria-hidden="true"></i> Settings</a>
+                                                </li>
+                                            </template>
                                         </ul>
                                     </li>
                                 </template>
@@ -258,18 +260,21 @@
             </div>
             <!-- End of navigation bar -->
 
-
             <!--Breadcrumb-->
-            <ol hidden$="{{!_isBreadcrumbVisible}}" id="breadcrumb" class="breadcrumb" style="margin-bottom: 1px;padding-left: 40px"></ol>
-
+            <div>
+                <ol hidden$="{{!_isBreadcrumbVisible}}" id="breadcrumb" class="breadcrumb" style="margin-bottom: 1px;padding-left: 40px"></ol>
+            </div>
 
             <!-- This is where main application is rendered -->
             <div>
                 <template is="dom-if" if="{{config.enabledComponents.home}}">
                     <div class="center">
                         <div class="content" id="home">
-                            <welcome-web project={{opencgaSession.project}} study="{{opencgaSession.study.alias}}" version="{{config.version}}"
-                                         cellbase-client={{cellbaseClient}} on-search="quickSearch"></welcome-web>
+                            <welcome-web opencga-session="{{opencgaSession}}"
+                                         version="{{config.version}}"
+                                         cellbase-client={{cellbaseClient}}
+                                         on-search="quickSearch">
+                            </welcome-web>
                         </div>
 
                     </div>
@@ -359,14 +364,16 @@
 
                 <template is="dom-if" if="{{config.enabledComponents.panel}}">
                     <div class="content" id="panel">
-                        <opencga-panel-browser opencga-session="{{opencgaSession}}" opencga-client="{{opencgaClient}}" cellbase-client="{{cellbaseClient}}"
-                                               on-notifymessage="onNotifyMessage" event-notify-name="{{config.notifyEventMessage}}" ></opencga-panel-browser>
+                        <opencga-panel-browser opencga-session="{{opencgaSession}}" opencga-client="{{opencgaClient}}"
+                                               cellbase-client="{{cellbaseClient}}"
+                                               on-notifymessage="onNotifyMessage" event-notify-name="{{config.notifyEventMessage}}">
+                        </opencga-panel-browser>
                     </div>
                 </template>
 
                 <template is="dom-if" if="{{config.enabledComponents.beacon}}">
                     <div class="content" id="beacon">
-                        <variant-beacon opencga-client="{{opencgaClient}}" project="{{opencgaSession.project}}" studies="{{opencgaSession.project.studies}}"
+                        <variant-beacon opencga-session="{{opencgaSession}}"
                                         hosts="{{config.tools.beacon.hosts}}">
                         </variant-beacon>
                     </div>
@@ -881,48 +888,48 @@
                 this.renderHashFragments();
             }
 
-            _setup(projects) {
-                // We check that at least one project with one study exist, otherwise we do not do anything
-                if (UtilsNew.isNotUndefined(projects) && projects.length > 0 && projects[0].studies.length > 0) {
-                    this.projects = projects;
-                    this.project = projects[0];
-                    this.study = projects[0].studies[0];
-
-                    let _this = this;
-                    let projectPromises = [];
-                    projects.forEach(function (project) {
-                        let studyPromises = [];
-                        project.studies.forEach(function (study) {
-                            studyPromises.push(_this.opencgaClient.studies().summary(project.alias + ":" + study.alias));
-                        });
-                        projectPromises.push(Promise.all(studyPromises)
-                            .then(function (responses) {
-                                let studies = [];
-                                responses.forEach(function (response) {
-                                    let study = response.response[0].result[0];
-                                    study.creationDate = moment(study.creationDate, "YYYYMMDDHHmmss").format('D MMM YY');
-                                    studies.push(study);
-                                });
-                                return studies;
-                            }));
-                    });
-
-                    let _projects = [];
-                    Promise.all(projectPromises)
-                        .then(function (responses) {
-                            for (let i = 0; i < responses.length; i++) {
-                                _projects.push({
-                                    id: _this.projects[i].id,
-                                    alias: _this.projects[i].alias,
-                                    name: _this.projects[i].name,
-                                    organism: _this.projects[i].organism,
-                                    studies: responses[i]
-                                });
-                            }
-                            _this.studySummaries = _projects;
-                        });
-                }
-            }
+            // _setup(projects) {
+            //     // We check that at least one project with one study exist, otherwise we do not do anything
+            //     if (UtilsNew.isNotUndefined(projects) && projects.length > 0 && projects[0].studies.length > 0) {
+            //         this.projects = projects;
+            //         this.project = projects[0];
+            //         this.study = projects[0].studies[0];
+            //
+            //         let _this = this;
+            //         let projectPromises = [];
+            //         projects.forEach(function (project) {
+            //             let studyPromises = [];
+            //             project.studies.forEach(function (study) {
+            //                 studyPromises.push(_this.opencgaClient.studies().summary(project.alias + ":" + study.alias));
+            //             });
+            //             projectPromises.push(Promise.all(studyPromises)
+            //                 .then(function (responses) {
+            //                     let studies = [];
+            //                     responses.forEach(function (response) {
+            //                         let study = response.response[0].result[0];
+            //                         study.creationDate = moment(study.creationDate, "YYYYMMDDHHmmss").format('D MMM YY');
+            //                         studies.push(study);
+            //                     });
+            //                     return studies;
+            //                 }));
+            //         });
+            //
+            //         let _projects = [];
+            //         Promise.all(projectPromises)
+            //             .then(function (responses) {
+            //                 for (let i = 0; i < responses.length; i++) {
+            //                     _projects.push({
+            //                         id: _this.projects[i].id,
+            //                         alias: _this.projects[i].alias,
+            //                         name: _this.projects[i].name,
+            //                         organism: _this.projects[i].organism,
+            //                         studies: responses[i]
+            //                     });
+            //                 }
+            //                 _this.studySummaries = _projects;
+            //             });
+            //     }
+            // }
 
             renderHashFragments() {
                 console.log("renderHashFragments - DEBUG")
diff --git a/src/welcome.html b/src/welcome.html
index 714b0e526..6467fa49a 100644
--- a/src/welcome.html
+++ b/src/welcome.html
@@ -43,18 +43,20 @@ <h2>Overview</h2>
             <!--placeholder="Search for a gene, transcript, protein or a variant" on-blur="onBlur" on-keyup="onKeyup">-->
             <!--<br>-->
 
-            <div style="padding: 20px 10px">
-                <input id="welcomeSearchTextBox" type="text" class="form-control input-lg" list="FeatureDatalist" on-keyup="callAutocomplete"
-                       placeholder="Search for gene symbols, genomic regions or variants" value="">
-                <datalist id="FeatureDatalist"></datalist>
-                <!-- Examples -->
-                <span style="font-size: 0.8em; padding-left: 10px">
+            <template is="dom-if" if="{{checkProjects}}">
+                <div style="padding: 20px 10px">
+                    <input id="welcomeSearchTextBox" type="text" class="form-control input-lg" list="FeatureDatalist" on-keyup="callAutocomplete"
+                           placeholder="Search for gene symbols, genomic regions or variants" value="">
+                    <datalist id="FeatureDatalist"></datalist>
+                    <!-- Examples -->
+                    <span style="font-size: 0.8em; padding-left: 10px">
                     Examples - Gene: <a on-click="onExampleClick" data-type="gene" style="cursor: pointer">BRCA2</a>,
                     Region: <a on-click="onExampleClick" data-type="region" style="cursor: pointer">3</a>, <a on-click="onExampleClick" data-type="region" style="cursor: pointer">3:113000-1150000</a>,
                     SNP: <a on-click="onExampleClick" data-type="snp" style="cursor: pointer">rs445909</a>
                     Variant: <a on-click="onExampleClick" data-type="variant" style="cursor: pointer">13:32962274:G:T</a>
                 </span>
-            </div>
+                </div>
+            </template>
             <br>
             <h4>Note:</h4>
             <p style="font-size:14px">
@@ -74,6 +76,8 @@ <h4>Note:</h4>
 
             constructor() {
                 super();
+
+                this.checkProjects = false;
             }
 
             static get is() {
@@ -82,6 +86,10 @@ <h4>Note:</h4>
 
             static get properties() {
                 return {
+                    opencgaSession: {
+                        type: Object,
+                        observer: "opencgaSessionObserver"
+                    },
                     version: {
                         type: String
                     },
@@ -105,6 +113,14 @@ <h4>Note:</h4>
             //     }
             // }
 
+            opencgaSessionObserver() {
+                if (UtilsNew.isNotUndefinedOrNull(this.opencgaSession) && UtilsNew.isNotUndefinedOrNull(this.opencgaSession.project)) {
+                    this.checkProjects = true;
+                } else {
+                    this.checkProjects = false;
+                }
+            }
+
             onExampleClick(e) {
                 let query = {};
                 switch (e.currentTarget.dataset.type) {
@@ -137,7 +153,7 @@ <h4>Note:</h4>
                 let featureId = PolymerUtils.getElementById("welcomeSearchTextBox").value;
                 if (UtilsNew.isNotEmpty(featureId)) {
                     let query = {};
-                    if (featureId.startsWith("chr") || featureId.match(/^\d/)) {
+                    if (featureId.startsWith("chr") || featureId === "X" || featureId === "Y" || featureId === "MT" || featureId.match(/^\d/)) {
                         if (featureId.split(":").length < 3) {
                             // It's a region, contains only one ':' character
                             query.region = featureId;