diff --git a/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md b/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md
index 2299a1573a9..51ae981b732 100644
--- a/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md
+++ b/src/OpenTelemetry.Instrumentation.GrpcNetClient/CHANGELOG.md
@@ -2,6 +2,14 @@
 
 ## Unreleased
 
+* **Breaking Change** :
+  [SuppressDownstreamInstrumentation](https://github.com/open-telemetry/opentelemetry-dotnet/tree/main/src/OpenTelemetry.Instrumentation.GrpcNetClient#suppressdownstreaminstrumentation)
+  option will no longer be supported when used with certain versions of
+  `OpenTelemetry.Instrumentation.Http` package. Check out this
+  [issue](https://github.com/open-telemetry/opentelemetry-dotnet/issues/5092)
+  for details and workaround.
+  ([#5077](https://github.com/open-telemetry/opentelemetry-dotnet/pull/5077))
+
 ## 1.6.0-beta.3
 
 Released 2023-Nov-17
diff --git a/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md b/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
index 2d5b686bfcc..5ef8ca9eb84 100644
--- a/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
+++ b/src/OpenTelemetry.Instrumentation.Http/CHANGELOG.md
@@ -11,6 +11,14 @@
 * Update activity DisplayName as per the specification.
   ([#5078](https://github.com/open-telemetry/opentelemetry-dotnet/pull/5078))
 
+* Removed reference to `OpenTelemetry` package. This is a **breaking change**
+  for users relying on
+  [SuppressDownstreamInstrumentation](https://github.com/open-telemetry/opentelemetry-dotnet/tree/main/src/OpenTelemetry.Instrumentation.GrpcNetClient#suppressdownstreaminstrumentation)
+  option in `OpenTelemetry.Instrumentation.GrpcNetClient`. For details, check
+  out this
+  [issue](https://github.com/open-telemetry/opentelemetry-dotnet/issues/5092).
+  ([#5077](https://github.com/open-telemetry/opentelemetry-dotnet/pull/5077))
+
 ## 1.6.0-beta.3
 
 Released 2023-Nov-17
diff --git a/src/OpenTelemetry.Instrumentation.Http/HttpClientInstrumentationOptions.cs b/src/OpenTelemetry.Instrumentation.Http/HttpClientInstrumentationOptions.cs
index 30c2b41641d..f0cd19691e2 100644
--- a/src/OpenTelemetry.Instrumentation.Http/HttpClientInstrumentationOptions.cs
+++ b/src/OpenTelemetry.Instrumentation.Http/HttpClientInstrumentationOptions.cs
@@ -20,9 +20,7 @@
 using System.Net.Http;
 #endif
 using System.Runtime.CompilerServices;
-using Microsoft.Extensions.Configuration;
 using OpenTelemetry.Instrumentation.Http.Implementation;
-using static OpenTelemetry.Internal.HttpSemanticConventionHelper;
 
 namespace OpenTelemetry.Instrumentation.Http;
 
@@ -31,23 +29,6 @@ namespace OpenTelemetry.Instrumentation.Http;
 /// </summary>
 public class HttpClientInstrumentationOptions
 {
-    internal readonly HttpSemanticConvention HttpSemanticConvention;
-
-    /// <summary>
-    /// Initializes a new instance of the <see cref="HttpClientInstrumentationOptions"/> class.
-    /// </summary>
-    public HttpClientInstrumentationOptions()
-        : this(new ConfigurationBuilder().AddEnvironmentVariables().Build())
-    {
-    }
-
-    internal HttpClientInstrumentationOptions(IConfiguration configuration)
-    {
-        Debug.Assert(configuration != null, "configuration was null");
-
-        this.HttpSemanticConvention = GetSemanticConventionOptIn(configuration);
-    }
-
     /// <summary>
     /// Gets or sets a filter function that determines whether or not to
     /// collect telemetry on a per request basis.
diff --git a/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs b/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs
index fb14e16c87f..f71707b37a5 100644
--- a/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs
+++ b/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerDiagnosticListener.cs
@@ -104,11 +104,6 @@ public void OnStartActivity(Activity activity, object payload)
         // By this time, samplers have already run and
         // activity.IsAllDataRequested populated accordingly.
 
-        if (Sdk.SuppressInstrumentation)
-        {
-            return;
-        }
-
         if (!TryFetchRequest(payload, out HttpRequestMessage request))
         {
             HttpInstrumentationEventSource.Log.NullPayload(nameof(HttpHandlerDiagnosticListener), nameof(this.OnStartActivity));
diff --git a/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerMetricsDiagnosticListener.cs b/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerMetricsDiagnosticListener.cs
index b3d45af15e8..15f6b6c1023 100644
--- a/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerMetricsDiagnosticListener.cs
+++ b/src/OpenTelemetry.Instrumentation.Http/Implementation/HttpHandlerMetricsDiagnosticListener.cs
@@ -66,11 +66,6 @@ public override void OnEventWritten(string name, object payload)
 
     public void OnStopEventWritten(Activity activity, object payload)
     {
-        if (Sdk.SuppressInstrumentation)
-        {
-            return;
-        }
-
         if (TryFetchRequest(payload, out HttpRequestMessage request))
         {
             // see the spec https://github.com/open-telemetry/semantic-conventions/blob/v1.23.0/docs/http/http-metrics.md
diff --git a/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj b/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
index b9295759edf..32f80e31c21 100644
--- a/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
+++ b/src/OpenTelemetry.Instrumentation.Http/OpenTelemetry.Instrumentation.Http.csproj
@@ -12,24 +12,22 @@
 
   <ItemGroup>
     <Compile Include="$(RepoRoot)\src\Shared\Guard.cs" Link="Includes\Guard.cs" />
-    <Compile Include="$(RepoRoot)\src\Shared\EnvironmentVariables\*.cs" Link="Includes\EnvironmentVariables\%(Filename).cs" />
-    <Compile Include="$(RepoRoot)\src\Shared\HttpSemanticConventionHelper.cs" Link="Includes\HttpSemanticConventionHelper.cs" />
-    <Compile Include="$(RepoRoot)\src\Shared\Options\*.cs" Link="Includes\Options\%(Filename).cs" />
     <Compile Include="$(RepoRoot)\src\Shared\Shims\NullableAttributes.cs" Link="Includes\Shims\NullableAttributes.cs" />
     <Compile Include="$(RepoRoot)\src\Shared\RequestMethodHelper.cs" Link="Includes\RequestMethodHelper.cs" />
   </ItemGroup>
 
   <ItemGroup Condition="'$(RunningDotNetPack)' != 'true'">
-    <ProjectReference Include="$(RepoRoot)\src\OpenTelemetry\OpenTelemetry.csproj" />
+    <ProjectReference Include="$(RepoRoot)\src\OpenTelemetry.Api.ProviderBuilderExtensions\OpenTelemetry.Api.ProviderBuilderExtensions.csproj" />
   </ItemGroup>
 
   <!-- Instrumentation packages when published should take a dependency only on the latest stable version of the API/SDK. -->
   <ItemGroup Condition="'$(RunningDotNetPack)' == 'true'">
-    <PackageReference Include="OpenTelemetry" />
+    <PackageReference Include="OpenTelemetry.Api.ProviderBuilderExtensions" />
   </ItemGroup>
 
   <ItemGroup>
     <Reference Include="System.Net.Http" Condition="'$(TargetFramework)' == '$(NetFrameworkMinimumSupportedVersion)'" />
+    <PackageReference Include="Microsoft.Extensions.Options" />
   </ItemGroup>
 
 </Project>
diff --git a/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs b/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs
index f8bb13a615c..cf0863091f0 100644
--- a/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs
+++ b/src/OpenTelemetry.Instrumentation.Http/TracerProviderBuilderExtensions.cs
@@ -72,8 +72,6 @@ public static TracerProviderBuilder AddHttpClientInstrumentation(
             {
                 services.Configure(name, configureHttpClientInstrumentationOptions);
             }
-
-            services.RegisterOptionsFactory(configuration => new HttpClientInstrumentationOptions(configuration));
         });
 
 #if NETFRAMEWORK
diff --git a/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs b/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs
index e94ae3ef9e9..53328008bfb 100644
--- a/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs
+++ b/test/OpenTelemetry.Instrumentation.Grpc.Tests/GrpcTests.client.cs
@@ -390,7 +390,7 @@ public void GrpcAndHttpClientInstrumentationIsInvoked(bool shouldEnrich)
         Assert.Equal(shouldEnrich ? "yes" : "no", grpcSpan.Tags.Where(tag => tag.Key == "enrichedWithHttpResponseMessage").FirstOrDefault().Value);
     }
 
-    [Fact]
+    [Fact(Skip = "https://github.com/open-telemetry/opentelemetry-dotnet/issues/5092")]
     public void GrpcAndHttpClientInstrumentationWithSuppressInstrumentation()
     {
         var uri = new Uri($"http://localhost:{this.server.Port}");
@@ -443,7 +443,7 @@ public void GrpcAndHttpClientInstrumentationWithSuppressInstrumentation()
         Assert.Equal(0, grpcSpan4.GetTagValue(SemanticConventions.AttributeRpcGrpcStatusCode));
     }
 
-    [Fact]
+    [Fact(Skip = "https://github.com/open-telemetry/opentelemetry-dotnet/issues/5092")]
     public void GrpcPropagatesContextWithSuppressInstrumentationOptionSetToTrue()
     {
         try
@@ -586,7 +586,7 @@ public void GrpcDoesNotPropagateContextWithSuppressInstrumentationOptionSetToFal
         }
     }
 
-    [Fact]
+    [Fact(Skip = "https://github.com/open-telemetry/opentelemetry-dotnet/issues/5092")]
     public void GrpcClientInstrumentationRespectsSdkSuppressInstrumentation()
     {
         try
diff --git a/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs b/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs
index 0f0b487d5c9..97794e53d54 100644
--- a/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs
+++ b/test/OpenTelemetry.Instrumentation.Http.Tests/HttpClientTests.Basic.cs
@@ -278,7 +278,7 @@ public async Task InjectsHeadersAsync_CustomFormat()
         }));
     }
 
-    [Fact]
+    [Fact(Skip = "https://github.com/open-telemetry/opentelemetry-dotnet/issues/5092")]
     public async Task RespectsSuppress()
     {
         try