@@ -83,6 +83,7 @@ export const DRUGS_CURRENTLY_IN_ONCOKB = `Drug(s) currently in ${ONCOKB_TM}`;
83
83
export const DRUGS_REMOVED_FROM_ONCOKB = `Drug(s) removed from ${ ONCOKB_TM } ` ;
84
84
export const DRUGS_DEMOTED_IN_ONCOKB = `Drug(s) demoted in ${ ONCOKB_TM } ` ;
85
85
export const DRUGS_PROMOTED_IN_ONCOKB = `Drug(s) promoted in ${ ONCOKB_TM } ` ;
86
+ export const DRUGS_CHANGED_IN_ONCOKB = `Drug(s) changed in ${ ONCOKB_TM } ` ;
86
87
export const DRUGS_ASSOCIATED_WITH_CURRENT_LEVEL =
87
88
'Drug(s) Associated with the Current Level' ;
88
89
export const UPDATED_SENSITIVITY_LEVEL = 'Updated Sensitivity Level' ;
@@ -141,6 +142,16 @@ export const CHANGED_ANNOTATION_DRUG_COLUMNS = [
141
142
{ name : EVIDENCE } ,
142
143
] ;
143
144
145
+ export const CHANGED_ANNOTATION_DRUG_SAME_HIGHEST_LEVEL_COLUMNS = [
146
+ { name : LEVEL } ,
147
+ { name : GENE } ,
148
+ { name : MUTATION } ,
149
+ { name : CANCER_TYPE } ,
150
+ { name : DRUGS_CURRENTLY_IN_ONCOKB } ,
151
+ { name : DRUGS_CHANGED_IN_ONCOKB } ,
152
+ { name : EVIDENCE } ,
153
+ ] ;
154
+
144
155
export const CHANGED_ANNOTATION_ADDITIONAL_DRUG_SAME_LEVEL_COLUMNS = [
145
156
{ name : GENE } ,
146
157
{ name : MUTATION } ,
@@ -250,6 +261,167 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
250
261
// https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
251
262
252
263
export const NEWS_BY_DATE : { [ date : string ] : NewsData } = {
264
+ '07022024' : {
265
+ priorityNews : [
266
+ < span >
267
+ Release of{ ' ' }
268
+ < a
269
+ href = "https://sop.oncokb.org/?version=v4.1"
270
+ target = "_blank"
271
+ rel = "noopener noreferrer"
272
+ >
273
+ { ONCOKB_TM } SOP v4.1
274
+ </ a >
275
+ </ span > ,
276
+ < span >
277
+ Updated HUGO symbol for gene SLC9A3R1 to{ ' ' }
278
+ < GenePageLink hugoSymbol = "NHERF1" />
279
+ </ span > ,
280
+ ] ,
281
+ changedAnnotations : [
282
+ {
283
+ columnHeaderType :
284
+ AnnotationColumnHeaderType . PROMOTION_TUMOR_TYPE_SPECIFIC_EVIDENCE ,
285
+ content : [
286
+ [
287
+ 'KRAS' ,
288
+ 'G12C' ,
289
+ 'Colorectal Cancer' ,
290
+ < div >
291
+ < div style = { { fontStyle : 'italic' } } >
292
+ { DRUGS_CURRENTLY_IN_ONCOKB } :
293
+ </ div >
294
+ < div style = { { textDecoration : 'underline' } } > Sensitivity</ div >
295
+ < div >
296
+ Adagrasib + Cetuximab, Adagrasib + Panitumumab, Sotorasib +
297
+ Cetuximab, Sotorasib + Panitumumab (Level 2)
298
+ </ div >
299
+ < br > </ br >
300
+ < div style = { { textDecoration : 'underline' } } > Resistance</ div >
301
+ < div >
302
+ Tucatinib + Trastuzumab, Cetuximab, Panitumumab (Level R1)
303
+ </ div >
304
+ < br > </ br >
305
+ < div style = { { fontStyle : 'italic' } } >
306
+ { DRUGS_PROMOTED_IN_ONCOKB } :
307
+ </ div >
308
+ < div > Adagrasib + Cetuximab (Level 1)</ div >
309
+ </ div > ,
310
+ '2' ,
311
+ '1' ,
312
+ < WithSeparator separator = { EVIDENCE_COLUMN_SEPARATOR } >
313
+ < FdaApprovalLink
314
+ approval = "Adagrasib + Cetuximab"
315
+ link = "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-adagrasib-cetuximab-kras-g12c-mutated-colorectal-cancer"
316
+ />
317
+ < PMIDLink pmids = "38587856" />
318
+ </ WithSeparator > ,
319
+ ] ,
320
+ [
321
+ 'KRAS' ,
322
+ 'G12C' ,
323
+ 'Biliary Tract Cancer' ,
324
+ 'Adagrasib' ,
325
+ '3A' ,
326
+ '2' ,
327
+ < WithSeparator separator = { EVIDENCE_COLUMN_SEPARATOR } >
328
+ < span >
329
+ Inclusion in NCCN Biliary Tract Cancer Guidelines V2.2024
330
+ </ span >
331
+ < PMIDLink pmids = "37099736" />
332
+ </ WithSeparator > ,
333
+ ] ,
334
+ ] ,
335
+ } ,
336
+ {
337
+ columnHeaderType : AnnotationColumnHeaderType . ADDITIONAL_SAME_LEVEL_DRUG ,
338
+ title : `Updated therapeutic implications - Addition of therapy(s) associated with a tumor type-specific leveled alteration(s) (without changing the alteration's highest level of evidence)` ,
339
+ content : [
340
+ [
341
+ 'EGFR' ,
342
+ 'Exon 19 in-frame deletion, L858R' ,
343
+ 'Non-Small Cell Lung Cancer' ,
344
+ '1' ,
345
+ 'Erlotinib, Afatinib, Gefitinib, Dacomitinib, Erlotinib + Ramucirumab, Osimertinib (Level 1); Patritumab Deruxtecan (Level 3A)' ,
346
+ 'Osimertinib + Chemotherapy (Level 1); Amivantamab + Chemotherapy (Level 2); Amivantamab + Lazertinib (Level 3A)' ,
347
+ < WithSeparator separator = { EVIDENCE_COLUMN_SEPARATOR } >
348
+ < FdaApprovalLink
349
+ approval = "Osimertinib with Chemotherapy"
350
+ link = "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-osimertinib-chemotherapy-egfr-mutated-non-small-cell-lung-cancer"
351
+ />
352
+ < span >
353
+ Inclusion of Amivantamab + Chemotherapy in NCCN Non-Small Cell
354
+ Lung Cancer Guidelines V5.2024
355
+ </ span >
356
+ < PMIDLink
357
+ pmids = "37937763, 37710001, 37879444, 38924756"
358
+ wrapText
359
+ />
360
+ </ WithSeparator > ,
361
+ ] ,
362
+ [
363
+ 'EGFR' ,
364
+ 'S768I, L861Q, G719X' ,
365
+ 'Non-Small Cell Lung Cancer' ,
366
+ '1' ,
367
+ 'Afatinib (Level 1); Osimertinib (Level 2); Patritumab Deruxtecan (Level 3A)' ,
368
+ 'Erlotinib, Gefitinib, Dacomitinib, Amivantamab + Chemotherapy (Level 2); Amivantamab + Lazertinib (Level 3A)' ,
369
+ < WithSeparator separator = { EVIDENCE_COLUMN_SEPARATOR } >
370
+ < span >
371
+ Inclusion of Erlotinib, Gefitinib, Dacomitinib and Amivantamab +
372
+ Chemotherapy in NCCN Non-Small Cell Lung Cancer Guidelines
373
+ V5.2024
374
+ </ span >
375
+ < PMIDLink pmids = "37879444, 25668120, 35770100" wrapText />
376
+ < AbstractLink
377
+ abstract = "Cho, B.C. et al., Abstract #8516, ASCO 2024"
378
+ link = "https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.8516"
379
+ />
380
+ </ WithSeparator > ,
381
+ ] ,
382
+ [
383
+ 'ERBB2' ,
384
+ 'Amplification' ,
385
+ 'Biliary Tract Cancer' ,
386
+ '2' ,
387
+ 'Trastuzumab + Pertuzumab' ,
388
+ 'Tucatinib + Trastuzumab (Level 2)' ,
389
+ < WithSeparator separator = { EVIDENCE_COLUMN_SEPARATOR } >
390
+ < span >
391
+ Inclusion in NCCN Biliary Tract Cancer Guidelines V2.2024
392
+ </ span >
393
+ < PMIDLink pmids = "37751561" />
394
+ </ WithSeparator > ,
395
+ ] ,
396
+ ] ,
397
+ } ,
398
+ {
399
+ columnHeaderType :
400
+ AnnotationColumnHeaderType . DRUG_UPDATE_SAME_HIGHEST_LEVEL ,
401
+ content : [
402
+ [
403
+ '1' ,
404
+ 'NTRK1, NTRK2, NTRK3' ,
405
+ 'Fusions' ,
406
+ 'All Solid Tumors' ,
407
+ 'Larotrectinib, Entrectinib (Level 1); Repotrectinib (Level 3A)' ,
408
+ 'Repotrectinib (Level 1)' ,
409
+ < WithSeparator separator = { EVIDENCE_COLUMN_SEPARATOR } >
410
+ < FdaApprovalLink
411
+ approval = "Repotrectinib"
412
+ link = "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-repotrectinib-adult-and-pediatric-patients-ntrk-gene-fusion-positive"
413
+ /> { ' ' }
414
+ < AbstractLink
415
+ abstract = "Solomon, B.J., et al., Abstract #1372P, Ann Oncol Vol 34, Suppl 2, 2023"
416
+ link = "https://www.annalsofoncology.org/article/S0923-7534(23)03242-8/fulltext"
417
+ />
418
+ </ WithSeparator > ,
419
+ ] ,
420
+ ] ,
421
+ } ,
422
+ ] ,
423
+ newlyAddedGenes : [ 'LMNA' , 'PRCC' , 'UBA1' , 'UBTF' , 'RIOK2' ] ,
424
+ } ,
253
425
'06042024' : {
254
426
priorityNews : [
255
427
< span >
@@ -283,7 +455,10 @@ export const NEWS_BY_DATE: { [date: string]: NewsData } = {
283
455
Inclusion in Colon Cancer NCCN Guidelines V2.2024 and in Small
284
456
Bowel Adenocarcinoma NCCN Guidelines V3.2024
285
457
</ span >
286
- < PMIDLink pmids = "26028255, 31682550, 28734759, 37917058" />
458
+ < PMIDLink
459
+ pmids = "26028255, 31682550, 28734759, 37917058"
460
+ wrapText
461
+ />
287
462
< AbstractLink
288
463
abstract = "Chae et al. Abstract# 3417, AACR 2020"
289
464
link = "https://aacrjournals.org/cancerres/article/80/16_Supplement/3417/642689/Abstract-3417-A-phase-II-basket-trial-of-dual-anti"
@@ -306,7 +481,10 @@ export const NEWS_BY_DATE: { [date: string]: NewsData } = {
306
481
Inclusion in Colon Cancer NCCN Guidelines V2.2024 and in Small
307
482
Bowel Adenocarcinoma NCCN Guidelines V3.2024
308
483
</ span >
309
- < PMIDLink pmids = "26028255, 31682550, 28734759, 37917058" />
484
+ < PMIDLink
485
+ pmids = "26028255, 31682550, 28734759, 37917058"
486
+ wrapText
487
+ />
310
488
< AbstractLink
311
489
abstract = "Chae et al. Abstract# 3417, AACR 2020"
312
490
link = "https://aacrjournals.org/cancerres/article/80/16_Supplement/3417/642689/Abstract-3417-A-phase-II-basket-trial-of-dual-anti"
0 commit comments