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Update news for v4.18 (#1131)
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src/main/webapp/app/config/constants.tsx

+1
Original file line numberDiff line numberDiff line change
@@ -800,6 +800,7 @@ export type DataRelease = {
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};
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export const DATA_RELEASES: DataRelease[] = [
803+
{ date: '07022024', version: 'v4.18' },
803804
{ date: '06042024', version: 'v4.17' },
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{ date: '05012024', version: 'v4.16' },
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{ date: '03212024', version: 'v4.15' },

src/main/webapp/app/pages/aboutGroup/FdaRecognitionPage.tsx

+2-2
Original file line numberDiff line numberDiff line change
@@ -72,7 +72,7 @@ const FdaRecognitionPage = () => {
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<h5>Important Database Links</h5>
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<ul>
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<li>
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<SopPageLink version={2.0} />
75+
<SopPageLink version={4.1} />
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</li>
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<li>
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<LevelOfEvidencePageLink
@@ -148,7 +148,7 @@ const FdaRecognitionPage = () => {
148148
<h5>Scope of {ONCOKB_TM} Recognition</h5>
149149
<p>
150150
The FDA has reviewed all {ONCOKB_TM} processes documented in the{' '}
151-
<SopPageLink version={2.0} />, which include the following:
151+
<SopPageLink version={4.1} />, which include the following:
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</p>
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<ol>
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<li>

src/main/webapp/app/pages/newsPage/ChangedAnnotatonListItem.tsx

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Original file line numberDiff line numberDiff line change
@@ -10,6 +10,7 @@ import {
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CHANGED_ANNOTATION_SENSITIVITY_LEVEL_COLUMNS,
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UPDATED_IMPLICATION_COLUMNS,
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CHANGED_ANNOTATION_DRUG_REMOVAL_SAME_HIGHEST_LEVEL_COLUMNS,
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CHANGED_ANNOTATION_DRUG_SAME_HIGHEST_LEVEL_COLUMNS,
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} from 'app/pages/newsPage/NewsPageContent';
1415
import { SimpleTable, SimpleTableRow } from 'app/components/SimpleTable';
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import { Row } from 'react-bootstrap';
@@ -32,6 +33,7 @@ export enum AnnotationColumnHeaderType {
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ADDITIONAL_SENSITIVITY_LEVEL_DRUG,
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DRUG_REMOVAL,
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DRUG_REMOVAL_SAME_HIGHEST_LEVEL,
36+
DRUG_UPDATE_SAME_HIGHEST_LEVEL,
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DEMOTION_TUMOR_TYPE_SPECIFIC_EVIDENCE,
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PROMOTION_TUMOR_TYPE_SPECIFIC_EVIDENCE,
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NEW_ALTERATION_WITH_LEVEL,
@@ -61,6 +63,11 @@ export const ChangedAnnotationListItem = (props: {
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defaultTitle =
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'Updated therapeutic implications - Addition of therapies for variants with a level of evidence';
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break;
66+
case AnnotationColumnHeaderType.DRUG_UPDATE_SAME_HIGHEST_LEVEL:
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annotationColumnHeader = CHANGED_ANNOTATION_DRUG_SAME_HIGHEST_LEVEL_COLUMNS;
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useOneLineRowClass = false;
69+
defaultTitle = `Updated therapeutic implications - Changed drug specific tumor-type level of evidence for an alteration-tumor type-drug association currently in OncoKB (without changing the alteration's highest level of evidence)`;
70+
break;
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case AnnotationColumnHeaderType.ADDITIONAL_DIFF_LEVEL_DRUG:
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annotationColumnHeader = CHANGED_ANNOTATION_ADDITIONAL_DRUG_DIFF_LEVEL_COLUMNS;
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useOneLineRowClass = false;

src/main/webapp/app/pages/newsPage/NewsPage.tsx

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Original file line numberDiff line numberDiff line change
@@ -91,6 +91,7 @@ export default class NewsPage extends React.Component<{
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<CitationText />
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</div>
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<div className="mt-2">
94+
<NewsList date={'07022024'} />
9495
<NewsList date={'06042024'} />
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<NewsList date={'05012024'} />
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<NewsList date={'03212024'} />

src/main/webapp/app/pages/newsPage/NewsPageContent.tsx

+180-2
Original file line numberDiff line numberDiff line change
@@ -83,6 +83,7 @@ export const DRUGS_CURRENTLY_IN_ONCOKB = `Drug(s) currently in ${ONCOKB_TM}`;
8383
export const DRUGS_REMOVED_FROM_ONCOKB = `Drug(s) removed from ${ONCOKB_TM}`;
8484
export const DRUGS_DEMOTED_IN_ONCOKB = `Drug(s) demoted in ${ONCOKB_TM}`;
8585
export const DRUGS_PROMOTED_IN_ONCOKB = `Drug(s) promoted in ${ONCOKB_TM}`;
86+
export const DRUGS_CHANGED_IN_ONCOKB = `Drug(s) changed in ${ONCOKB_TM}`;
8687
export const DRUGS_ASSOCIATED_WITH_CURRENT_LEVEL =
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'Drug(s) Associated with the Current Level';
8889
export const UPDATED_SENSITIVITY_LEVEL = 'Updated Sensitivity Level';
@@ -141,6 +142,16 @@ export const CHANGED_ANNOTATION_DRUG_COLUMNS = [
141142
{ name: EVIDENCE },
142143
];
143144

145+
export const CHANGED_ANNOTATION_DRUG_SAME_HIGHEST_LEVEL_COLUMNS = [
146+
{ name: LEVEL },
147+
{ name: GENE },
148+
{ name: MUTATION },
149+
{ name: CANCER_TYPE },
150+
{ name: DRUGS_CURRENTLY_IN_ONCOKB },
151+
{ name: DRUGS_CHANGED_IN_ONCOKB },
152+
{ name: EVIDENCE },
153+
];
154+
144155
export const CHANGED_ANNOTATION_ADDITIONAL_DRUG_SAME_LEVEL_COLUMNS = [
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{ name: GENE },
146157
{ name: MUTATION },
@@ -250,6 +261,167 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
250261
// https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
251262

252263
export const NEWS_BY_DATE: { [date: string]: NewsData } = {
264+
'07022024': {
265+
priorityNews: [
266+
<span>
267+
Release of{' '}
268+
<a
269+
href="https://sop.oncokb.org/?version=v4.1"
270+
target="_blank"
271+
rel="noopener noreferrer"
272+
>
273+
{ONCOKB_TM} SOP v4.1
274+
</a>
275+
</span>,
276+
<span>
277+
Updated HUGO symbol for gene SLC9A3R1 to{' '}
278+
<GenePageLink hugoSymbol="NHERF1" />
279+
</span>,
280+
],
281+
changedAnnotations: [
282+
{
283+
columnHeaderType:
284+
AnnotationColumnHeaderType.PROMOTION_TUMOR_TYPE_SPECIFIC_EVIDENCE,
285+
content: [
286+
[
287+
'KRAS',
288+
'G12C',
289+
'Colorectal Cancer',
290+
<div>
291+
<div style={{ fontStyle: 'italic' }}>
292+
{DRUGS_CURRENTLY_IN_ONCOKB}:
293+
</div>
294+
<div style={{ textDecoration: 'underline' }}>Sensitivity</div>
295+
<div>
296+
Adagrasib + Cetuximab, Adagrasib + Panitumumab, Sotorasib +
297+
Cetuximab, Sotorasib + Panitumumab (Level 2)
298+
</div>
299+
<br></br>
300+
<div style={{ textDecoration: 'underline' }}>Resistance</div>
301+
<div>
302+
Tucatinib + Trastuzumab, Cetuximab, Panitumumab (Level R1)
303+
</div>
304+
<br></br>
305+
<div style={{ fontStyle: 'italic' }}>
306+
{DRUGS_PROMOTED_IN_ONCOKB}:
307+
</div>
308+
<div>Adagrasib + Cetuximab (Level 1)</div>
309+
</div>,
310+
'2',
311+
'1',
312+
<WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
313+
<FdaApprovalLink
314+
approval="Adagrasib + Cetuximab"
315+
link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-adagrasib-cetuximab-kras-g12c-mutated-colorectal-cancer"
316+
/>
317+
<PMIDLink pmids="38587856" />
318+
</WithSeparator>,
319+
],
320+
[
321+
'KRAS',
322+
'G12C',
323+
'Biliary Tract Cancer',
324+
'Adagrasib',
325+
'3A',
326+
'2',
327+
<WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
328+
<span>
329+
Inclusion in NCCN Biliary Tract Cancer Guidelines V2.2024
330+
</span>
331+
<PMIDLink pmids="37099736" />
332+
</WithSeparator>,
333+
],
334+
],
335+
},
336+
{
337+
columnHeaderType: AnnotationColumnHeaderType.ADDITIONAL_SAME_LEVEL_DRUG,
338+
title: `Updated therapeutic implications - Addition of therapy(s) associated with a tumor type-specific leveled alteration(s) (without changing the alteration's highest level of evidence)`,
339+
content: [
340+
[
341+
'EGFR',
342+
'Exon 19 in-frame deletion, L858R',
343+
'Non-Small Cell Lung Cancer',
344+
'1',
345+
'Erlotinib, Afatinib, Gefitinib, Dacomitinib, Erlotinib + Ramucirumab, Osimertinib (Level 1); Patritumab Deruxtecan (Level 3A)',
346+
'Osimertinib + Chemotherapy (Level 1); Amivantamab + Chemotherapy (Level 2); Amivantamab + Lazertinib (Level 3A)',
347+
<WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
348+
<FdaApprovalLink
349+
approval="Osimertinib with Chemotherapy"
350+
link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-osimertinib-chemotherapy-egfr-mutated-non-small-cell-lung-cancer"
351+
/>
352+
<span>
353+
Inclusion of Amivantamab + Chemotherapy in NCCN Non-Small Cell
354+
Lung Cancer Guidelines V5.2024
355+
</span>
356+
<PMIDLink
357+
pmids="37937763, 37710001, 37879444, 38924756"
358+
wrapText
359+
/>
360+
</WithSeparator>,
361+
],
362+
[
363+
'EGFR',
364+
'S768I, L861Q, G719X',
365+
'Non-Small Cell Lung Cancer',
366+
'1',
367+
'Afatinib (Level 1); Osimertinib (Level 2); Patritumab Deruxtecan (Level 3A)',
368+
'Erlotinib, Gefitinib, Dacomitinib, Amivantamab + Chemotherapy (Level 2); Amivantamab + Lazertinib (Level 3A)',
369+
<WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
370+
<span>
371+
Inclusion of Erlotinib, Gefitinib, Dacomitinib and Amivantamab +
372+
Chemotherapy in NCCN Non-Small Cell Lung Cancer Guidelines
373+
V5.2024
374+
</span>
375+
<PMIDLink pmids="37879444, 25668120, 35770100" wrapText />
376+
<AbstractLink
377+
abstract="Cho, B.C. et al., Abstract #8516, ASCO 2024"
378+
link="https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.8516"
379+
/>
380+
</WithSeparator>,
381+
],
382+
[
383+
'ERBB2',
384+
'Amplification',
385+
'Biliary Tract Cancer',
386+
'2',
387+
'Trastuzumab + Pertuzumab',
388+
'Tucatinib + Trastuzumab (Level 2)',
389+
<WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
390+
<span>
391+
Inclusion in NCCN Biliary Tract Cancer Guidelines V2.2024
392+
</span>
393+
<PMIDLink pmids="37751561" />
394+
</WithSeparator>,
395+
],
396+
],
397+
},
398+
{
399+
columnHeaderType:
400+
AnnotationColumnHeaderType.DRUG_UPDATE_SAME_HIGHEST_LEVEL,
401+
content: [
402+
[
403+
'1',
404+
'NTRK1, NTRK2, NTRK3',
405+
'Fusions',
406+
'All Solid Tumors',
407+
'Larotrectinib, Entrectinib (Level 1); Repotrectinib (Level 3A)',
408+
'Repotrectinib (Level 1)',
409+
<WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
410+
<FdaApprovalLink
411+
approval="Repotrectinib"
412+
link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-repotrectinib-adult-and-pediatric-patients-ntrk-gene-fusion-positive"
413+
/>{' '}
414+
<AbstractLink
415+
abstract="Solomon, B.J., et al., Abstract #1372P, Ann Oncol Vol 34, Suppl 2, 2023"
416+
link="https://www.annalsofoncology.org/article/S0923-7534(23)03242-8/fulltext"
417+
/>
418+
</WithSeparator>,
419+
],
420+
],
421+
},
422+
],
423+
newlyAddedGenes: ['LMNA', 'PRCC', 'UBA1', 'UBTF', 'RIOK2'],
424+
},
253425
'06042024': {
254426
priorityNews: [
255427
<span>
@@ -283,7 +455,10 @@ export const NEWS_BY_DATE: { [date: string]: NewsData } = {
283455
Inclusion in Colon Cancer NCCN Guidelines V2.2024 and in Small
284456
Bowel Adenocarcinoma NCCN Guidelines V3.2024
285457
</span>
286-
<PMIDLink pmids="26028255, 31682550, 28734759, 37917058" />
458+
<PMIDLink
459+
pmids="26028255, 31682550, 28734759, 37917058"
460+
wrapText
461+
/>
287462
<AbstractLink
288463
abstract="Chae et al. Abstract# 3417, AACR 2020"
289464
link="https://aacrjournals.org/cancerres/article/80/16_Supplement/3417/642689/Abstract-3417-A-phase-II-basket-trial-of-dual-anti"
@@ -306,7 +481,10 @@ export const NEWS_BY_DATE: { [date: string]: NewsData } = {
306481
Inclusion in Colon Cancer NCCN Guidelines V2.2024 and in Small
307482
Bowel Adenocarcinoma NCCN Guidelines V3.2024
308483
</span>
309-
<PMIDLink pmids="26028255, 31682550, 28734759, 37917058" />
484+
<PMIDLink
485+
pmids="26028255, 31682550, 28734759, 37917058"
486+
wrapText
487+
/>
310488
<AbstractLink
311489
abstract="Chae et al. Abstract# 3417, AACR 2020"
312490
link="https://aacrjournals.org/cancerres/article/80/16_Supplement/3417/642689/Abstract-3417-A-phase-II-basket-trial-of-dual-anti"

src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx

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@@ -474,7 +474,7 @@ const OncologyTherapiesPage: React.FunctionComponent<{}> = props => {
474474
'https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications'
475475
}
476476
>
477-
Content current as of 4/23/2024
477+
Content current as of 6/19/2024
478478
</Linkout>
479479
</div>
480480
<div>

src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json

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@@ -2198,5 +2198,25 @@
21982198
"targetedTx": "Y",
21992199
"pxTx": "Y",
22002200
"ngsTest": "Y"
2201+
},
2202+
{
2203+
"year": "2024",
2204+
"tx": "Tarlatamab",
2205+
"biomarker": "",
2206+
"agentClass": "Bispecific T-cell engager",
2207+
"drugTarget": "Bispecific DLL3-directed CD3 T-cell engager",
2208+
"targetedTx": "Y",
2209+
"pxTx": "N",
2210+
"ngsTest": "NA"
2211+
},
2212+
{
2213+
"year": "2024",
2214+
"tx": "Imetelstat",
2215+
"biomarker": "",
2216+
"agentClass": "Telomerase inhibitor",
2217+
"drugTarget": "Telomerase template antagonist",
2218+
"targetedTx": "Y",
2219+
"pxTx": "N",
2220+
"ngsTest": "NA"
22012221
}
22022222
]
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src/main/webapp/index.html

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@@ -15,15 +15,15 @@
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<meta name="twitter:site" content="@oncokb">
1616
<meta name="twitter:title" content="OncoKB™ - MSK's Precision Oncology Knowledge Base">
1717
<meta name="twitter:description" content="OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.">
18-
<meta name="twitter:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240604">
18+
<meta name="twitter:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240702">
1919
<meta name="twitter:url" content="https://www.oncokb.org/">
2020

2121
<meta property="og:site_name" content="OncoKB™">
2222
<meta property="og:type" content="website">
2323
<meta property="og:url" content="https://www.oncokb.org/">
2424
<meta property="og:title" content="OncoKB™ - MSK's Precision Oncology Knowledge Base">
2525
<meta property="og:description" content="OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.">
26-
<meta property="og:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240604">
26+
<meta property="og:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240702">
2727

2828
<link rel="mask-icon" href="content/images/favicon/safari-pinned-tab.svg" color="#0968c3">
2929
<!-- Preload the customized fonts, so the html knows how to pain the page -->

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