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October 26, 2018 Release (#224)
* Update the LoE with R2 * Update News * Include v1.17 data
1 parent cbf0f76 commit 063674e

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‎app/resources/files/LevelsOfEvidence.pdf

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‎app/resources/files/LevelsOfEvidence.ppt

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‎app/resources/images/level.jpg

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‎app/resources/images/level.png

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‎app/scripts/app.js

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}, {content: '3855 Variants'}, {content: '60 Tumor Types'}]
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};
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$rootScope.data = {
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lastUpdate: 'October 3, 2018',
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version: '1.16_patch_1',
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lastUpdate: 'October 26, 2018',
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version: '1.17',
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levelColors: {
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'1': '#33A02C',
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'2A': '#1F78B4',

‎app/scripts/controllers/actionalGenes.js

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treatments: [],
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numOfGenes: 0,
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numOfAlterations: 0
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},
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{
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key: 'r2',
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title: 'R2',
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titleStyleClass: 'level-R2',
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description: 'Clinical evidence of resistance',
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treatments: [],
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numOfGenes: 0,
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numOfAlterations: 0
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}
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]
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};
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url: 'LEVEL_R1',
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variable: 'r1',
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loadingStatus: 'r1'
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}, {
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url: 'LEVEL_R2',
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variable: 'r2',
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loadingStatus: 'r2'
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}];
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_.each(levels, function(level) {
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$scope.status.loading.level[level.loadingStatus] = true;

‎app/scripts/controllers/news.js

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'Level 3': [
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'RET - Oncogenic Mutations - Medullary Thyroid Cancer - LOXO-292 (<b>added as new association</b>)',
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]
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},
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'10262018': {
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'Level 4': [
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'ALK - C1156Y, G1269A, I1171N, L1196M - Non-Small Cell Lung Cancer - Lorlatinib',
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'EGFR - D761Y - Non-Small Cell Lung Cancer - Osimertinib'
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]
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}
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};
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$scope.data.newlyAddedLevelFour = [
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];
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$scope.data.newlyAddedGenes = {
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'08172018': ['ACTG1', 'ARHGEF28', 'ARID3A', 'ARID3B', 'ARID3C', 'ARID4A', 'ARID4B', 'ARID5A', 'ATP6AP1', 'ATP6V1B2', 'ATXN2', 'BACH2', 'BCL11B', 'BCORL1', 'BCR', 'BTG1', 'CD28', 'CD58', 'CIITA', 'CRBN', 'CUX1', 'DDX3X', 'DTX1', 'DUSP22', 'EGR1', 'EP400', 'ESCO2', 'ETNK1', 'FANCD2', 'FAS', 'FBXO11', 'FURIN', 'GNA12', 'GNA13', 'GNB1', 'GTF2I', 'HDAC1', 'HDAC4', 'HDAC7', 'HIF1A', 'HIST1H1B', 'HIST1H1D'],
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'10012018': ['HIST1H1E','SETD6','SETD5','SETD7','SETDB2','SETDB1','SETD4','SETD3','SETD1B','U2AF2','TET3','NFE2','IRF8','IRF1','IKZF3','JARID2','NCSTN','HIST1H2BO','HIST1H2AC','HIST1H2BG','HIST1H2BJ','HIST1H2BK','HIST1H2BC','HIST1H2AG','HIST1H2AL','HIST1H2AM','TYK2']
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'10012018': ['HIST1H1E','SETD6','SETD5','SETD7','SETDB2','SETDB1','SETD4','SETD3','SETD1B','U2AF2','TET3','NFE2','IRF8','IRF1','IKZF3','JARID2','NCSTN','HIST1H2BO','HIST1H2AC','HIST1H2BG','HIST1H2BJ','HIST1H2BK','HIST1H2BC','HIST1H2AG','HIST1H2AL','HIST1H2AM','TYK2'],
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'10262018': ['NT5C2','P2RY8','PCBP1','PDS5B','PTPN1','PTPN2 ','STAG1','TRAF3','TRAF5'],
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};
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});

‎app/styles/_news.scss

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vertical-align: 20%;
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}
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.table {
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margin-bottom: 0;
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ul {
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padding-left: 17px;
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list-style: none;

‎app/views/about.html

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implications of specific cancer gene alterations. It is developed and maintained by the Knowledge Systems
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group in the <a href="https://www.mskcc.org/research-areas/programs-centers/molecular-oncology">Marie Josée
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and Henry R. Kravis Center for Molecular Oncology</a> at Memorial Sloan Kettering Cancer
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Center (MSK), in partnership with Quest Diagnostics.</p>
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Center (MSK), in partnership with Quest Diagnostics and Watson for Genomics, IBM.</p>
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<p>Curated by a network of clinical fellows, research fellows, and faculty members at MSK, OncoKB contains
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detailed information about specific alterations in {{numOfGenes}} cancer genes. The information is curated from various
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sources, such as guidelines from the FDA, NCCN, or ASCO, <a href="https://clinicaltrials.gov/">ClinicalTrials.gov</a>

‎app/views/news.html

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</p>
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<p ng-bind-html="data.citationURL"></p>
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</div>
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<h3>October 26, 2018</h3>
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<div>
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<ul>
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<li>Level R2 alterations in <a href="#/gene/ALK">ALK</a>, <a
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href="#/gene/EGFR">EGFR</a>, and <a href="#/gene/MET">MET</a> are now included in the Actionable
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Genes page
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</li>
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<li>Updated Actionable Genes
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<div class="row">
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<table class="table">
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<thead>
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<th class="col-lg-1 col-sm-2 col-xs-3">Level</th>
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<th class="col-lg-11 col-sm-10 col-xs-9">Update</th>
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</thead>
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<tbody>
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<tr ng-repeat="(key, value) in data.updatedActionableGenes['10262018']">
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<td>{{key}}</td>
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<td>
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<ul>
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<li ng-repeat="item in value"><span ng-bind-html="item"></span></li>
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</ul>
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</td>
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</tr>
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</tbody>
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</table>
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</div>
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</li>
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<li>Addition of {{data.newlyAddedGenes['10262018'].length}} new heme-associated genes:
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<div class="newly-added-genes">
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<span class="gene" ng-repeat="hugo in data.newlyAddedGenes['10262018']"><a
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href="#/gene/{{hugo}}">{{hugo}}</a></span>
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</div>
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</li>
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<li>OncoTree updated from version <a target="_blank"
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href="http://oncotree.mskcc.org/#/home?version=oncotree_2017_06_21">2017_06_21</a>
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to version <a target="_blank"
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href="http://oncotree.mskcc.org/#/home?version=oncotree_2018_06_15">2018_06_15</a>
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</li>
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<li>OncoKB is monitoring the following drugs that were granted <a target="_blank"
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href="https://www.fda.gov/forpatients/approvals/fast/ucm405397.htm">Breakthrough
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Therapy</a> designation by the
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FDA:
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<ul class="bullet" style="margin-top: 10px">
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<li>Oct 2, 2018: <a target="_blank"
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href="https://www.onclive.com/web-exclusives/fda-grants-rucaparib-breakthrough-designation-for-mcrpc">
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Rucarparib in adult patients with BRCA1/2-positive metastatic castration-resistant disease
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following at least 1 androgen receptor–directed therapy and taxane-based chemotherapy.</a>
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</li>
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</ul>
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</li>
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</ul>
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</div>
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<h3>October 1, 2018</h3>
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<div>
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<ul>

‎app/views/team.html

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<li>Yelena Janjigian, MD</li>
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<li>Thomas Kaley, MD</li>
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<li>Vicky Makker, MD</li>
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<li>Antonio Omuro, MD</li>
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<li>Paul Paik, MD</li>
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<li>Michael Postow, MD</li>
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<li>Dana Rathkopf, MD</li>
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<li>Neel Shah</li>
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<li>Eneda Toska, PhD</li>
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<li>Jiaojiao Wang, MSc</li>
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<li>Antonio Omuro, MD</li>
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</ul>
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</div>
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<div class="col-lg-4 col-md-4 col-sm-6 item-5">
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<h5>Quest Diagnostics</h5>
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<ul>
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<li>Feras M Abu Hantash, PhD</li>
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<li>Andrew Grupe, PhD</li>
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<li>Matthew Beer, BSc</li>
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</ul>
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</div>
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</div>
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</div>
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</div>

‎data/v1.17/README.md

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# v1.17
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## Related releases
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[OncoKB Public Website, October 26, 2018 Updates](https://github.com/oncokb/oncokb-public/releases/tag/0.11)
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[OncoKB Core/Curate v0.3.3 Release](https://github.com/oncokb/oncokb/releases/tag/v0.3.4)
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‎data/v1.17/allActionableVariants.json

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