diff --git a/oba-base.owl b/oba-base.owl
index 91474853..49515c5f 100644
--- a/oba-base.owl
+++ b/oba-base.owl
@@ -12,7 +12,7 @@
xmlns:terms1="http://www.geneontology.org/formats/oboInOwl#http://purl.org/dc/terms/"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
-
+
A collection of biological attributes (traits) covering all kingdoms of life. Interoperable with VT (vertebrate trait ontology) and TO (plant trait ontology). Extends PATO.
Ontology of Biological Attributes (OBA)
@@ -20,7 +20,7 @@
oba
1.2
- 2024-09-12
+ 2024-11-26
@@ -2080,6 +2080,12 @@
+
+
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@@ -5878,6 +5884,12 @@
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@@ -5938,18 +5950,6 @@
-
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@@ -7684,12 +7684,6 @@
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@@ -8248,6 +8242,12 @@
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@@ -9028,12 +9028,6 @@
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@@ -9346,6 +9340,12 @@
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@@ -9664,6 +9670,12 @@
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@@ -49516,7 +49528,7 @@
-
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@@ -49526,23 +49538,23 @@
-
+
- The rate of a mitochondrial respirasome.
- rate of mitochondrial respirasome
- mitochondrial respirasome rate
+ The rate of a respiratory chain complex.
+ rate of respiratory chain complex
+ respiratory chain complex rate
- The rate of a mitochondrial respirasome.
+ The rate of a respiratory chain complex.
AUTO:patterns/patterns/entity_attribute
- rate of mitochondrial respirasome
+ rate of respiratory chain complex
AUTO:patterns/patterns/entity_attribute
@@ -65974,35 +65986,33 @@
-
+
-
-
+
-
-
+
- The rate of a mitochondrial proton-transporting ATP synthase complex.
- rate of mitochondrial proton-transporting ATP synthase complex
- mitochondrial proton-transporting ATP synthase complex rate
+ The rate of a proton-transporting ATP synthase complex.
+ rate of proton-transporting ATP synthase complex
+ proton-transporting ATP synthase complex rate
- The rate of a mitochondrial proton-transporting ATP synthase complex.
+ The rate of a proton-transporting ATP synthase complex.
AUTO:patterns/patterns/entity_attribute
- rate of mitochondrial proton-transporting ATP synthase complex
+ rate of proton-transporting ATP synthase complex
AUTO:patterns/patterns/entity_attribute
@@ -90470,20 +90480,20 @@
- The rate of a glucose import.
- rate of glucose import
- glucose import rate
+ The rate of a D-glucose import.
+ rate of D-glucose import
+ D-glucose import rate
- The rate of a glucose import.
+ The rate of a D-glucose import.
AUTO:patterns/patterns/entity_attribute
- rate of glucose import
+ rate of D-glucose import
AUTO:patterns/patterns/entity_attribute
@@ -90511,20 +90521,20 @@
- The amount of a glucose import.
- amount of glucose import
- glucose import amount
+ The amount of a D-glucose import.
+ amount of D-glucose import
+ D-glucose import amount
- The amount of a glucose import.
+ The amount of a D-glucose import.
AUTO:patterns/patterns/entity_attribute
- amount of glucose import
+ amount of D-glucose import
AUTO:patterns/patterns/entity_attribute
@@ -115581,6 +115591,7 @@
+
@@ -154819,20 +154830,20 @@
- The rate of a triglyceride lipase activity.
- rate of triglyceride lipase activity
- triglyceride lipase activity rate
+ The rate of a triacylglycerol lipase activity.
+ rate of triacylglycerol lipase activity
+ triacylglycerol lipase activity rate
- The rate of a triglyceride lipase activity.
+ The rate of a triacylglycerol lipase activity.
AUTO:patterns/patterns/entity_attribute
- rate of triglyceride lipase activity
+ rate of triacylglycerol lipase activity
AUTO:patterns/patterns/entity_attribute
@@ -176203,7 +176214,7 @@
-
+
@@ -176213,23 +176224,23 @@
-
+
- The rate of a L-tyrosine aminotransferase activity.
- rate of L-tyrosine aminotransferase activity
- L-tyrosine aminotransferase activity rate
+ The rate of a L-tyrosine-2-oxoglutarate transaminase activity.
+ rate of L-tyrosine-2-oxoglutarate transaminase activity
+ L-tyrosine-2-oxoglutarate transaminase activity rate
- The rate of a L-tyrosine aminotransferase activity.
+ The rate of a L-tyrosine-2-oxoglutarate transaminase activity.
AUTO:patterns/patterns/entity_attribute
- rate of L-tyrosine aminotransferase activity
+ rate of L-tyrosine-2-oxoglutarate transaminase activity
AUTO:patterns/patterns/entity_attribute
@@ -187451,34 +187462,32 @@
-
+
-
-
-
+
-
+
- The quality of a mitochondrial respirasome.
- quality of mitochondrial respirasome
- mitochondrial respirasome quality
+ The quality of a respiratory chain complex.
+ quality of respiratory chain complex
+ respiratory chain complex quality
- The quality of a mitochondrial respirasome.
+ The quality of a respiratory chain complex.
obo:oba/patterns/entity_attribute_part_of
- quality of mitochondrial respirasome
+ quality of respiratory chain complex
obo:oba/patterns/entity_attribute_part_of
@@ -206714,7 +206723,7 @@
-
+
@@ -206723,23 +206732,23 @@
-
+
- The quality of a hormone-sensitive lipase activity.
- quality of hormone-sensitive lipase activity
- hormone-sensitive lipase activity quality
+ The quality of a diacylglycerol lipase activity.
+ quality of diacylglycerol lipase activity
+ diacylglycerol lipase activity quality
- The quality of a hormone-sensitive lipase activity.
+ The quality of a diacylglycerol lipase activity.
obo:oba/patterns/entity_attribute_part_of
- quality of hormone-sensitive lipase activity
+ quality of diacylglycerol lipase activity
obo:oba/patterns/entity_attribute_part_of
@@ -213309,7 +213318,7 @@
-
+
@@ -213318,23 +213327,23 @@
-
+
- The quality of a L-tyrosine aminotransferase activity.
- quality of L-tyrosine aminotransferase activity
- L-tyrosine aminotransferase activity quality
+ The quality of a L-tyrosine-2-oxoglutarate transaminase activity.
+ quality of L-tyrosine-2-oxoglutarate transaminase activity
+ L-tyrosine-2-oxoglutarate transaminase activity quality
- The quality of a L-tyrosine aminotransferase activity.
+ The quality of a L-tyrosine-2-oxoglutarate transaminase activity.
obo:oba/patterns/entity_attribute_part_of
- quality of L-tyrosine aminotransferase activity
+ quality of L-tyrosine-2-oxoglutarate transaminase activity
obo:oba/patterns/entity_attribute_part_of
@@ -215763,20 +215772,20 @@
- The quality of a triglyceride lipase activity.
- quality of triglyceride lipase activity
- triglyceride lipase activity quality
+ The quality of a triacylglycerol lipase activity.
+ quality of triacylglycerol lipase activity
+ triacylglycerol lipase activity quality
- The quality of a triglyceride lipase activity.
+ The quality of a triacylglycerol lipase activity.
obo:oba/patterns/entity_attribute_part_of
- quality of triglyceride lipase activity
+ quality of triacylglycerol lipase activity
obo:oba/patterns/entity_attribute_part_of
@@ -557099,7 +557108,6 @@
The amount of a vascular cell adhesion protein 1 when measured in anatomical entity.
-
anatomical entity vascular cell adhesion protein 1 amount
soluble vascular cell adhesion molecule-1 amount
vascular cell adhesion molecule-1 amount
@@ -664935,6 +664943,147 @@
+
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+ A trait that affects the response to a stimulus with gabapentin.
+ https://orcid.org/0000-0001-6757-4744
+ response to gabapentin trait
+ trait in response to gabapentin
+
+
+
+
+
+
+
+
+
+
+
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+
+
+
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+
+
+
+
+
+
+
+
+
+ The age at which isolated dystonia manifestations first appear.
+ age at onset of isolated dystonia
+ age isolated dystonia symptoms begin
+ age of onset of isolated dystonia
+
+
+
+
+
+
+
+
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+
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+
+
+
+ The amount of a apolipoprotein(a) when measured in blood.
+ https://orcid.org/0000-0001-6757-4744
+ PMID:36959364
+ blood apolipoprotein(a) amount
+ amount of apolipoprotein(a) in blood
+
+
+
+
+ The amount of a apolipoprotein(a) when measured in blood.
+ AUTO:patterns/patterns/entity_attribute_location
+
+
+
+
+ blood apolipoprotein(a) amount
+ AUTO:patterns/patterns/entity_attribute_location
+
+
+
+
@@ -781350,6 +781499,12 @@
+
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+
diff --git a/oba.obo b/oba.obo
index 0939909f..9874e4d3 100644
--- a/oba.obo
+++ b/oba.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: releases/2024-09-12
+data-version: releases/2024-11-26
default-namespace: oba
idspace: dc http://purl.org/dc/elements/1.1/
idspace: foaf http://xmlns.com/foaf/0.1/
@@ -12,7 +12,7 @@ ontology: oba
property_value: dc:description "A collection of biological attributes (traits) covering all kingdoms of life. Interoperable with VT (vertebrate trait ontology) and TO (plant trait ontology). Extends PATO." xsd:string
property_value: dc:title "Ontology of Biological Attributes (OBA)" xsd:string
property_value: IAO:0000700 OBA:0000001
-property_value: owl:versionInfo "2024-09-12" xsd:string
+property_value: owl:versionInfo "2024-11-26" xsd:string
property_value: terms:license http://creativecommons.org/publicdomain/zero/1.0/
[Term]
@@ -267,13 +267,6 @@ def: "A glycerophosphocholine having an unspecified O-acyl substituent at the 1-
is_a: CHEBI:35267 ! quaternary ammonium ion
relationship: is_conjugate_acid_of CHEBI:78191 ! 2-lysophosphatidylcholine
-[Term]
-id: CHEBI:11424
-name: 2,3-dihydroxy-3-methylbutanoate
-is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion
-relationship: has_functional_parent CHEBI:17968 ! butyrate
-relationship: is_conjugate_base_of CHEBI:15689 ! 2,3-dihydroxy-3-methylbutanoic acid
-
[Term]
id: CHEBI:114785
name: erlotinib
@@ -292,19 +285,6 @@ def: "A glycerophosphocholine having an unspecified acyl group attached at the 2
is_a: CHEBI:35267 ! quaternary ammonium ion
relationship: is_conjugate_acid_of CHEBI:78192 ! 1-lysophosphatidylcholine
-[Term]
-id: CHEBI:11851
-name: 3-methyl-2-oxobutanoate
-def: "A 2-oxo monocarboxylic acid anion that is the conjugate base of 3-methyl-2-oxobutanoic acid, arising from deprotonation of the carboxy group." []
-is_a: CHEBI:191201 ! branched-chain keto acid anion
-is_a: CHEBI:35179 ! 2-oxo monocarboxylic acid anion
-is_a: CHEBI:58955 ! branched-chain fatty acid anion
-is_a: CHEBI:59836 ! oxo fatty acid anion
-relationship: has_functional_parent CHEBI:17968 ! butyrate
-relationship: is_conjugate_base_of CHEBI:16530 ! 3-methyl-2-oxobutanoic acid
-relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
-relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-
[Term]
id: CHEBI:119486
name: efavirenz
@@ -487,15 +467,6 @@ is_a: CHEBI:61469 ! polyanionic polymer
is_a: CHEBI:63551 ! carbohydrate acid derivative anion
relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid
-[Term]
-id: CHEBI:132177
-name: 2-hydroxy-3-methyl-2-butenoic acid
-def: "An alpha,beta-unsaturated monocarboxylic acid that is 3-methylbut-2-enoic acid in which the hydrogen at position 2 has been replaced by a hydroxy group." []
-is_a: CHEBI:49302 ! 2-hydroxy monocarboxylic acid
-is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid
-relationship: has_functional_parent CHEBI:37127 ! 3-methylbut-2-enoic acid
-relationship: is_tautomer_of CHEBI:16530 ! 3-methyl-2-oxobutanoic acid
-
[Term]
id: CHEBI:132233
name: 1-phenylpropan-2-amine
@@ -591,13 +562,6 @@ name: lysophosphatidic acid
def: "A member of the class of lysophosphatidic acids obtained by hydrolytic removal of one of the two acyl groups of any phosphatidic acid. A 'closed' class." []
is_a: CHEBI:32957 ! lysophosphatidic acids
-[Term]
-id: CHEBI:132943
-name: aspartate
-is_a: CHEBI:33558 ! alpha-amino-acid anion
-is_a: CHEBI:35693 ! dicarboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:22660 ! aspartic acid
-
[Term]
id: CHEBI:132944
name: octadec-9-enoate
@@ -1841,20 +1805,6 @@ relationship: is_conjugate_acid_of CHEBI:57392 ! propionyl-CoA(4-)
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
-[Term]
-id: CHEBI:15570
-name: D-alanine
-def: "The D-enantiomer of alanine." []
-is_a: CHEBI:16449 ! alanine
-is_a: CHEBI:16733 ! D-alpha-amino acid
-relationship: is_conjugate_acid_of CHEBI:32435 ! D-alaninate
-relationship: is_conjugate_base_of CHEBI:32436 ! D-alaninium
-relationship: is_enantiomer_of CHEBI:16977 ! L-alanine
-relationship: is_tautomer_of CHEBI:57416 ! D-alanine zwitterion
-relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
-relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-relationship: RO:0000087 CHEBI:77881 ! has role EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor
-
[Term]
id: CHEBI:155814
name: Cer(d40:2)
@@ -1917,21 +1867,6 @@ name: cyclobutanes
def: "Cyclobutane and its derivatives formed by substitution." []
is_a: CHEBI:33598 ! carbocyclic compound
-[Term]
-id: CHEBI:15684
-name: (R)-2,3-dihydroxy-3-methylbutanoic acid
-is_a: CHEBI:15689 ! 2,3-dihydroxy-3-methylbutanoic acid
-relationship: is_conjugate_acid_of CHEBI:49072 ! (R)-2,3-dihydroxy-3-methylbutanoate
-
-[Term]
-id: CHEBI:15689
-name: 2,3-dihydroxy-3-methylbutanoic acid
-def: "A dihydroxy monocarboxylic acid that is isovaleric acid which is substituted by hydroxy groups at positions 2 and 3." []
-is_a: CHEBI:35972 ! dihydroxy monocarboxylic acid
-relationship: has_functional_parent CHEBI:28484 ! isovaleric acid
-relationship: has_functional_parent CHEBI:30772 ! butyric acid
-relationship: is_conjugate_acid_of CHEBI:11424 ! 2,3-dihydroxy-3-methylbutanoate
-
[Term]
id: CHEBI:15693
name: aldose
@@ -2223,6 +2158,16 @@ is_a: CHEBI:33695 ! information biomacromolecule
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: BFO:0000051 CHEBI:50319 ! has part nucleotide residue
+[Term]
+id: CHEBI:15999
+name: 4-hydroxyphenylpyruvic acid
+def: "A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group." []
+is_a: CHEBI:33853 ! phenols
+is_a: CHEBI:35910 ! 2-oxo monocarboxylic acid
+relationship: has_functional_parent CHEBI:32816 ! pyruvic acid
+relationship: is_conjugate_acid_of CHEBI:36242 ! 3-(4-hydroxyphenyl)pyruvate
+relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+
[Term]
id: CHEBI:16000
name: ethanolamine
@@ -2568,6 +2513,18 @@ relationship: is_conjugate_acid_of CHEBI:57706 ! 4-oxobutanoate
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+[Term]
+id: CHEBI:16296
+name: D-tryptophan
+def: "The D-enantiomer of tryptophan." []
+is_a: CHEBI:16733 ! D-alpha-amino acid
+is_a: CHEBI:27897 ! tryptophan
+relationship: is_conjugate_acid_of CHEBI:32716 ! D-tryptophanate
+relationship: is_conjugate_base_of CHEBI:32717 ! D-tryptophanium
+relationship: is_enantiomer_of CHEBI:16828 ! L-tryptophan
+relationship: is_tautomer_of CHEBI:57719 ! D-tryptophan zwitterion
+relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
+
[Term]
id: CHEBI:16300
name: alpha-D-ribose 1-phosphate
@@ -2697,35 +2654,6 @@ relationship: is_enantiomer_of CHEBI:46967 ! L-erythro-sphingosine
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:16414
-name: L-valine
-def: "The L-enantiomer of valine." []
-is_a: CHEBI:26463 ! pyruvate family amino acid
-is_a: CHEBI:27266 ! valine
-relationship: is_conjugate_acid_of CHEBI:32851 ! L-valinate
-relationship: is_conjugate_base_of CHEBI:32852 ! L-valinium
-relationship: is_enantiomer_of CHEBI:27477 ! D-valine
-relationship: is_tautomer_of CHEBI:57762 ! L-valine zwitterion
-relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
-relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
-relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
-relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
-relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
-relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
-
-[Term]
-id: CHEBI:16444
-name: 2-acetyllactic acid
-def: "A derivative of butyric acid having methyl, hydroxy and oxo substituents at the 2-, 2- and 3-positions respectively." []
-is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone
-is_a: CHEBI:47881 ! 3-oxo monocarboxylic acid
-is_a: CHEBI:49302 ! 2-hydroxy monocarboxylic acid
-relationship: has_functional_parent CHEBI:30772 ! butyric acid
-relationship: is_conjugate_acid_of CHEBI:57774 ! 2-acetyllactate
-relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
-
[Term]
id: CHEBI:16449
name: alanine
@@ -2807,18 +2735,6 @@ relationship: RO:0000087 CHEBI:77974 ! has role food packaging gas
relationship: RO:0000087 CHEBI:78017 ! has role food propellant
relationship: RO:0000087 CHEBI:78433 ! has role refrigerant
-[Term]
-id: CHEBI:16530
-name: 3-methyl-2-oxobutanoic acid
-def: "A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid." []
-is_a: CHEBI:191197 ! branched-chain keto acid
-is_a: CHEBI:35910 ! 2-oxo monocarboxylic acid
-relationship: has_functional_parent CHEBI:30772 ! butyric acid
-relationship: is_conjugate_acid_of CHEBI:11851 ! 3-methyl-2-oxobutanoate
-relationship: is_tautomer_of CHEBI:132177 ! 2-hydroxy-3-methyl-2-butenoic acid
-relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
-relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-
[Term]
id: CHEBI:16541
name: protein polypeptide chain
@@ -3358,6 +3274,25 @@ relationship: has_parent_hydride CHEBI:8386 ! pregnane
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+[Term]
+id: CHEBI:16828
+name: L-tryptophan
+def: "The L-enantiomer of tryptophan." []
+is_a: CHEBI:27897 ! tryptophan
+is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid
+relationship: is_conjugate_acid_of CHEBI:32702 ! L-tryptophanate
+relationship: is_conjugate_base_of CHEBI:32704 ! L-tryptophanium
+relationship: is_enantiomer_of CHEBI:16296 ! D-tryptophan
+relationship: is_tautomer_of CHEBI:57912 ! L-tryptophan zwitterion
+relationship: RO:0000087 CHEBI:27027 ! has role micronutrient
+relationship: RO:0000087 CHEBI:35469 ! has role antidepressant
+relationship: RO:0000087 CHEBI:50733 ! has role nutraceutical
+relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
+relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
+relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
+relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
+relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+
[Term]
id: CHEBI:168396
name: mycophenolic acid
@@ -3526,18 +3461,6 @@ is_a: CHEBI:76629 ! 2-lysophosphatidic acid
relationship: is_conjugate_acid_of CHEBI:57970 ! 1-acyl-sn-glycerol 3-phosphate(2-)
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
-[Term]
-id: CHEBI:16977
-name: L-alanine
-def: "The L-enantiomer of alanine." []
-is_a: CHEBI:16449 ! alanine
-is_a: CHEBI:26463 ! pyruvate family amino acid
-relationship: is_conjugate_acid_of CHEBI:32431 ! L-alaninate
-relationship: is_conjugate_base_of CHEBI:32432 ! L-alaninium
-relationship: is_enantiomer_of CHEBI:15570 ! D-alanine
-relationship: is_tautomer_of CHEBI:57972 ! L-alanine zwitterion
-relationship: RO:0000087 CHEBI:77881 ! has role EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor
-
[Term]
id: CHEBI:16988
name: D-ribose
@@ -3783,14 +3706,6 @@ relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabol
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:84735 ! has role algal metabolite
-[Term]
-id: CHEBI:17217
-name: 2-butenoic acid
-def: "A butenoic acid having the double bond at position C-2." []
-is_a: CHEBI:22959 ! butenoic acid
-is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid
-relationship: is_conjugate_acid_of CHEBI:36258 ! but-2-enoate
-
[Term]
id: CHEBI:1722
name: 3beta-hydroxy-Delta(5)-steroid
@@ -5084,13 +4999,6 @@ relationship: RO:0000087 CHEBI:64909 ! has role poison
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:18409
-name: (2S)-2-hydroxy-2-methyl-3-oxobutanoic acid
-is_a: CHEBI:16444 ! 2-acetyllactic acid
-relationship: is_conjugate_acid_of CHEBI:58476 ! (2S)-2-hydroxy-2-methyl-3-oxobutanoate
-relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
-
[Term]
id: CHEBI:18421
name: superoxide
@@ -5208,20 +5116,6 @@ name: 1-pyrrolinecarboxylic acid
is_a: CHEBI:23763 ! pyrroline
is_a: CHEBI:25384 ! monocarboxylic acid
-[Term]
-id: CHEBI:191197
-name: branched-chain keto acid
-def: "An oxo carboxylic acid in which the parent hydrocarbon chain has one or more alkyl substituents. Derivatives formed from the first step in the metabolism of branched-chain amino acids and can provide important information on animal health and disease." []
-is_a: CHEBI:25754 ! oxo carboxylic acid
-relationship: is_conjugate_acid_of CHEBI:191201 ! branched-chain keto acid anion
-
-[Term]
-id: CHEBI:191201
-name: branched-chain keto acid anion
-def: "An oxo carboxylic acid anion that is the conjugate base of branched-chain keto acid resulting from the deprotonation of the carboxy group." []
-is_a: CHEBI:35903 ! oxo carboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:191197 ! branched-chain keto acid
-
[Term]
id: CHEBI:19138
name: 12-HETE
@@ -5486,13 +5380,6 @@ name: acyl group
def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
is_a: CHEBI:33247 ! organic group
-[Term]
-id: CHEBI:22251
-name: adenosine bisphosphate
-is_a: CHEBI:22256 ! adenosine phosphate
-is_a: CHEBI:61078 ! purine nucleoside bisphosphate
-is_a: CHEBI:61079 ! ribonucleoside bisphosphate
-
[Term]
id: CHEBI:22256
name: adenosine phosphate
@@ -5733,17 +5620,6 @@ def: "An L-alpha-amino acid which is L-aspartic acid or any of the essential ami
is_a: CHEBI:15705 ! L-alpha-amino acid
is_a: CHEBI:83813 ! proteinogenic amino acid
-[Term]
-id: CHEBI:22660
-name: aspartic acid
-def: "An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent" []
-is_a: CHEBI:26167 ! polar amino acid
-is_a: CHEBI:33704 ! alpha-amino acid
-is_a: CHEBI:66873 ! C4-dicarboxylic acid
-relationship: BFO:0000051 CHEBI:41402 ! has part carboxymethyl group
-relationship: is_conjugate_acid_of CHEBI:35391 ! aspartate(1-)
-relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
-
[Term]
id: CHEBI:22676
name: auxin
@@ -5960,14 +5836,6 @@ name: butenedioic acid
is_a: CHEBI:66873 ! C4-dicarboxylic acid
relationship: is_conjugate_acid_of CHEBI:37155 ! hydrogen butenedioate
-[Term]
-id: CHEBI:22959
-name: butenoic acid
-def: "Any C4, straight-chain fatty acid containing one double bond." []
-is_a: CHEBI:25413 ! monounsaturated fatty acid
-is_a: CHEBI:26666 ! short-chain fatty acid
-is_a: CHEBI:59202 ! straight-chain fatty acid
-
[Term]
id: CHEBI:229627
name: long-chain fatty acyl-L-carnitine
@@ -8661,17 +8529,6 @@ relationship: is_conjugate_acid_of CHEBI:62501 ! folate(2-)
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:27477
-name: D-valine
-def: "The D-enantiomer of valine." []
-is_a: CHEBI:16733 ! D-alpha-amino acid
-is_a: CHEBI:27266 ! valine
-relationship: is_conjugate_acid_of CHEBI:32855 ! D-valinate
-relationship: is_conjugate_base_of CHEBI:32856 ! D-valinium
-relationship: is_enantiomer_of CHEBI:16414 ! L-valine
-relationship: is_tautomer_of CHEBI:74338 ! D-valine zwitterion
-
[Term]
id: CHEBI:27547
name: zeaxanthin
@@ -9701,15 +9558,6 @@ is_a: CHEBI:29987 ! glutamate(2-)
relationship: is_conjugate_base_of CHEBI:29986 ! D-glutamate(1-)
relationship: is_enantiomer_of CHEBI:29988 ! L-glutamate(2-)
-[Term]
-id: CHEBI:29995
-name: aspartate(2-)
-def: "A C4-dicarboxylate that is the dianion obtained by the deprotonation of both the carboxy groups of aspartic acid." []
-is_a: CHEBI:132943 ! aspartate
-is_a: CHEBI:61336 ! C4-dicarboxylate
-relationship: is_conjugate_base_of CHEBI:35391 ! aspartate(1-)
-relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
-
[Term]
id: CHEBI:29998
name: D-serine residue
@@ -10344,43 +10192,6 @@ relationship: is_conjugate_base_of CHEBI:32425 ! (11Z)-icos-11-enoic acid
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:32431
-name: L-alaninate
-def: "The L-enantiomer of alaninate." []
-is_a: CHEBI:32439 ! alaninate
-is_a: CHEBI:59814 ! L-alpha-amino acid anion
-relationship: is_conjugate_base_of CHEBI:16977 ! L-alanine
-relationship: is_enantiomer_of CHEBI:32435 ! D-alaninate
-relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
-
-[Term]
-id: CHEBI:32432
-name: L-alaninium
-def: "The L-enantiomer of alaninium." []
-is_a: CHEBI:32440 ! alaninium
-relationship: is_conjugate_acid_of CHEBI:16977 ! L-alanine
-relationship: is_enantiomer_of CHEBI:32436 ! D-alaninium
-relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
-
-[Term]
-id: CHEBI:32435
-name: D-alaninate
-def: "The D-enantiomer of alaninate." []
-is_a: CHEBI:32439 ! alaninate
-relationship: is_conjugate_base_of CHEBI:15570 ! D-alanine
-relationship: is_enantiomer_of CHEBI:32431 ! L-alaninate
-relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-
-[Term]
-id: CHEBI:32436
-name: D-alaninium
-def: "An alaninium that is the conjugate acid of D-alanine." []
-is_a: CHEBI:32440 ! alaninium
-relationship: is_conjugate_acid_of CHEBI:15570 ! D-alanine
-relationship: is_enantiomer_of CHEBI:32432 ! L-alaninium
-relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-
[Term]
id: CHEBI:32439
name: alaninate
@@ -11005,6 +10816,45 @@ name: argininium(2+)
is_a: CHEBI:33719 ! alpha-amino-acid cation
relationship: is_conjugate_acid_of CHEBI:32696 ! argininium(1+)
+[Term]
+id: CHEBI:32702
+name: L-tryptophanate
+def: "The L-enantiomer of tryptophanate." []
+is_a: CHEBI:32727 ! tryptophanate
+is_a: CHEBI:59814 ! L-alpha-amino acid anion
+relationship: is_conjugate_base_of CHEBI:16828 ! L-tryptophan
+relationship: is_enantiomer_of CHEBI:32716 ! D-tryptophanate
+relationship: RO:0000087 CHEBI:75767 ! has role animal metabolite
+relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
+
+[Term]
+id: CHEBI:32704
+name: L-tryptophanium
+def: "The L-enantiomer of tryptophanium." []
+is_a: CHEBI:32728 ! tryptophanium
+relationship: is_conjugate_acid_of CHEBI:16828 ! L-tryptophan
+relationship: is_enantiomer_of CHEBI:32717 ! D-tryptophanium
+relationship: RO:0000087 CHEBI:75767 ! has role animal metabolite
+relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
+
+[Term]
+id: CHEBI:32716
+name: D-tryptophanate
+def: "The D-enantiomer of tryptophanate." []
+is_a: CHEBI:32727 ! tryptophanate
+relationship: is_conjugate_base_of CHEBI:16296 ! D-tryptophan
+relationship: is_enantiomer_of CHEBI:32702 ! L-tryptophanate
+relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
+
+[Term]
+id: CHEBI:32717
+name: D-tryptophanium
+def: "The D-enantiomer of tryptophanium." []
+is_a: CHEBI:32728 ! tryptophanium
+relationship: is_conjugate_acid_of CHEBI:16296 ! D-tryptophan
+relationship: is_enantiomer_of CHEBI:32704 ! L-tryptophanium
+relationship: RO:0000087 CHEBI:76969 ! has role bacterial metabolite
+
[Term]
id: CHEBI:32727
name: tryptophanate
@@ -11182,43 +11032,6 @@ name: serine residue
is_a: CHEBI:33710 ! alpha-amino-acid residue
relationship: is_substituent_group_from CHEBI:17822 ! serine
-[Term]
-id: CHEBI:32851
-name: L-valinate
-def: "The L-enantiomer of valinate." []
-is_a: CHEBI:32859 ! valinate
-is_a: CHEBI:59814 ! L-alpha-amino acid anion
-relationship: is_conjugate_base_of CHEBI:16414 ! L-valine
-relationship: is_enantiomer_of CHEBI:32855 ! D-valinate
-relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
-
-[Term]
-id: CHEBI:32852
-name: L-valinium
-def: "The L-enantiomer of valinium." []
-is_a: CHEBI:32860 ! valinium
-relationship: is_conjugate_acid_of CHEBI:16414 ! L-valine
-relationship: is_enantiomer_of CHEBI:32856 ! D-valinium
-relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
-
-[Term]
-id: CHEBI:32855
-name: D-valinate
-def: "The D-enantiomer of valinate." []
-is_a: CHEBI:32859 ! valinate
-relationship: is_conjugate_base_of CHEBI:27477 ! D-valine
-relationship: is_enantiomer_of CHEBI:32851 ! L-valinate
-relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
-
-[Term]
-id: CHEBI:32856
-name: D-valinium
-def: "The D-enantiomer of valinium." []
-is_a: CHEBI:32860 ! valinium
-relationship: is_conjugate_acid_of CHEBI:27477 ! D-valine
-relationship: is_enantiomer_of CHEBI:32852 ! L-valinium
-relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
-
[Term]
id: CHEBI:32859
name: valinate
@@ -13215,14 +13028,6 @@ name: monosaccharide
def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
is_a: CHEBI:16646 ! carbohydrate
-[Term]
-id: CHEBI:35391
-name: aspartate(1-)
-def: "An alpha-amino-acid anion that is the conjugate base of aspartic acid." []
-is_a: CHEBI:132943 ! aspartate
-relationship: is_conjugate_acid_of CHEBI:29995 ! aspartate(2-)
-relationship: RO:0000087 CHEBI:78675 ! has role fundamental metabolite
-
[Term]
id: CHEBI:3540
name: cephalotaxine
@@ -14130,13 +13935,6 @@ name: dihydroxy monocarboxylic acid
def: "Any hydroxy monocarboxylic acid carrying at least two hydroxy groups." []
is_a: CHEBI:35868 ! hydroxy monocarboxylic acid
-[Term]
-id: CHEBI:35973
-name: 3-oxo monocarboxylic acid anion
-def: "An oxo monocarboxylic acid anion having the oxo group located at the 3-position (R = H or organyl group)." []
-is_a: CHEBI:35902 ! oxo monocarboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:47881 ! 3-oxo monocarboxylic acid
-
[Term]
id: CHEBI:35974
name: 4-oxo monocarboxylic acid anion
@@ -14174,12 +13972,6 @@ relationship: has_parent_hydride CHEBI:37605 ! octadec-9-ene
relationship: is_conjugate_acid_of CHEBI:132944 ! octadec-9-enoate
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
-[Term]
-id: CHEBI:36029
-name: butenoate
-is_a: CHEBI:2580 ! unsaturated fatty acid anion
-is_a: CHEBI:58951 ! short-chain fatty acid anion
-
[Term]
id: CHEBI:36033
name: icosatetraenoic acid
@@ -14343,6 +14135,16 @@ name: 5beta-cholanic acid
is_a: CHEBI:36237 ! cholanic acid
is_a: CHEBI:36248 ! 5beta-cholanic acids
+[Term]
+id: CHEBI:36242
+name: 3-(4-hydroxyphenyl)pyruvate
+def: "A 2-oxo monocarboxylic acid anion obtained by removal of a proton from the carboxylic acid group of 3-(4-hydroxyphenyl)pyruvic acid." []
+is_a: CHEBI:35179 ! 2-oxo monocarboxylic acid anion
+relationship: has_functional_parent CHEBI:15361 ! pyruvate
+relationship: is_conjugate_base_of CHEBI:15999 ! 4-hydroxyphenylpyruvic acid
+relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
+relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+
[Term]
id: CHEBI:36248
name: 5beta-cholanic acids
@@ -14351,13 +14153,6 @@ is_a: CHEBI:136889 ! 5beta steroid
is_a: CHEBI:36278 ! cholanic acids
relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane
-[Term]
-id: CHEBI:36258
-name: but-2-enoate
-def: "The conjugate base of but-2-enoic acid." []
-is_a: CHEBI:36029 ! butenoate
-relationship: is_conjugate_base_of CHEBI:17217 ! 2-butenoic acid
-
[Term]
id: CHEBI:36275
name: HETE
@@ -14972,22 +14767,6 @@ is_a: CHEBI:1372 ! 1-pyrroline-5-carboxylic acid
relationship: is_conjugate_acid_of CHEBI:17388 ! (S)-1-pyrroline-5-carboxylate
relationship: is_enantiomer_of CHEBI:36750 ! (R)-1-pyrroline-5-carboxylic acid
-[Term]
-id: CHEBI:37123
-name: nucleoside bisphosphate
-is_a: CHEBI:25608 ! nucleoside phosphate
-
-[Term]
-id: CHEBI:37127
-name: 3-methylbut-2-enoic acid
-def: "A methyl-branched fatty acid that is but-2-enoic acid bearing a methyl substituent at position 3." []
-is_a: CHEBI:25413 ! monounsaturated fatty acid
-is_a: CHEBI:26666 ! short-chain fatty acid
-is_a: CHEBI:62499 ! methyl-branched fatty acid
-is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid
-relationship: has_functional_parent CHEBI:17217 ! 2-butenoic acid
-relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
-
[Term]
id: CHEBI:37141
name: organobromine compound
@@ -15078,11 +14857,6 @@ relationship: RO:0000087 CHEBI:76779 ! has role EC 3.4.21.26 (prolyl oligopeptid
relationship: RO:0000087 CHEBI:77402 ! has role EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
-[Term]
-id: CHEBI:37240
-name: adenosine 3',5'-bisphosphate
-is_a: CHEBI:22251 ! adenosine bisphosphate
-
[Term]
id: CHEBI:37246
name: elemental sodium
@@ -16467,12 +16241,6 @@ is_a: CHEBI:37621 ! galactopyranose
relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76971 ! has role Escherichia coli metabolite
-[Term]
-id: CHEBI:41402
-name: carboxymethyl group
-is_a: CHEBI:50325 ! proteinogenic amino-acid side-chain group
-relationship: is_substituent_group_from CHEBI:15366 ! acetic acid
-
[Term]
id: CHEBI:41550
name: fluoroform
@@ -16618,6 +16386,17 @@ def: "A 1-phenylpropan-2-amine that has R configuration." []
is_a: CHEBI:132233 ! 1-phenylpropan-2-amine
relationship: is_enantiomer_of CHEBI:4469 ! (S)-amphetamine
+[Term]
+id: CHEBI:42797
+name: gabapentin
+def: "A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome." []
+is_a: CHEBI:33707 ! gamma-amino acid
+relationship: has_functional_parent CHEBI:16865 ! gamma-aminobutyric acid
+relationship: RO:0000087 CHEBI:35623 ! has role anticonvulsant
+relationship: RO:0000087 CHEBI:35703 ! has role xenobiotic
+relationship: RO:0000087 CHEBI:38215 ! has role calcium channel blocker
+relationship: RO:0000087 CHEBI:78298 ! has role environmental contaminant
+
[Term]
id: CHEBI:42977
name: 25-hydroxycholesterol
@@ -17426,12 +17205,6 @@ name: steroid ester
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:35701 ! ester
-[Term]
-id: CHEBI:47881
-name: 3-oxo monocarboxylic acid
-is_a: CHEBI:35871 ! oxo monocarboxylic acid
-relationship: is_conjugate_acid_of CHEBI:35973 ! 3-oxo monocarboxylic acid anion
-
[Term]
id: CHEBI:47882
name: cyclic polypyrrole
@@ -17808,13 +17581,6 @@ relationship: is_tautomer_of CHEBI:46814 ! 9H-purine-2,6,8-triol
relationship: is_tautomer_of CHEBI:46817 ! 7H-purine-2,6,8-triol
relationship: is_tautomer_of CHEBI:46823 ! 1H-purine-2,6,8-triol
-[Term]
-id: CHEBI:49072
-name: (R)-2,3-dihydroxy-3-methylbutanoate
-is_a: CHEBI:11424 ! 2,3-dihydroxy-3-methylbutanoate
-relationship: is_conjugate_base_of CHEBI:15684 ! (R)-2,3-dihydroxy-3-methylbutanoic acid
-relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
-
[Term]
id: CHEBI:49095
name: beta-amino-acid anion
@@ -19413,13 +19179,6 @@ relationship: is_conjugate_base_of CHEBI:15539 ! propionyl-CoA
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:57416
-name: D-alanine zwitterion
-def: "Zwitterionic form of D-alanine." []
-is_a: CHEBI:66916 ! alanine zwitterion
-relationship: is_tautomer_of CHEBI:15570 ! D-alanine
-
[Term]
id: CHEBI:57427
name: L-leucine zwitterion
@@ -19576,6 +19335,13 @@ relationship: is_conjugate_base_of CHEBI:16265 ! succinic semialdehyde
relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+[Term]
+id: CHEBI:57719
+name: D-tryptophan zwitterion
+def: "Zwitterionic form of D-tryptophan having an anionic carboxy group and a protonated alpha-amino group; major species at pH 7.3." []
+is_a: CHEBI:64554 ! tryptophan zwitterion
+relationship: is_tautomer_of CHEBI:16296 ! D-tryptophan
+
[Term]
id: CHEBI:57720
name: alpha-D-ribose 1-phosphate(2-)
@@ -19612,22 +19378,6 @@ relationship: is_conjugate_acid_of CHEBI:16393 ! sphingosine
relationship: is_enantiomer_of CHEBI:77956 ! L-erythro-sphingosine(1+)
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:57762
-name: L-valine zwitterion
-def: "An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-valine; major species at pH 7.3." []
-is_a: CHEBI:59869 ! L-alpha-amino acid zwitterion
-relationship: is_tautomer_of CHEBI:16414 ! L-valine
-
-[Term]
-id: CHEBI:57774
-name: 2-acetyllactate
-def: "The conjugate base of 2-acetyllactic acid; major species at pH 7.3." []
-is_a: CHEBI:35179 ! 2-oxo monocarboxylic acid anion
-is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:16444 ! 2-acetyllactic acid
-relationship: RO:0000087 CHEBI:75772 ! has role Saccharomyces cerevisiae metabolite
-
[Term]
id: CHEBI:5778
name: hydrochlorothiazide
@@ -19729,6 +19479,14 @@ relationship: RO:0000087 CHEBI:75771 ! has role mouse metabolite
relationship: RO:0000087 CHEBI:76924 ! has role plant metabolite
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
+[Term]
+id: CHEBI:57912
+name: L-tryptophan zwitterion
+def: "An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of L-tryptophan; major species at pH 7.3." []
+is_a: CHEBI:59869 ! L-alpha-amino acid zwitterion
+is_a: CHEBI:64554 ! tryptophan zwitterion
+relationship: is_tautomer_of CHEBI:16828 ! L-tryptophan
+
[Term]
id: CHEBI:57925
name: glutathionate(1-)
@@ -19795,13 +19553,6 @@ is_a: CHEBI:78166 ! 2-lysophosphatidate(2-)
relationship: is_conjugate_base_of CHEBI:16975 ! 1-acyl-sn-glycerol 3-phosphate
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:57972
-name: L-alanine zwitterion
-def: "Zwitterionic form of L-alanine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3." []
-is_a: CHEBI:66916 ! alanine zwitterion
-relationship: is_tautomer_of CHEBI:16977 ! L-alanine
-
[Term]
id: CHEBI:57977
name: bilirubin(2-)
@@ -20080,13 +19831,6 @@ is_a: CHEBI:38773 ! quinolinemonocarboxylate
relationship: is_conjugate_base_of CHEBI:18344 ! kynurenic acid
relationship: RO:0000087 CHEBI:77746 ! has role human metabolite
-[Term]
-id: CHEBI:58476
-name: (2S)-2-hydroxy-2-methyl-3-oxobutanoate
-def: "conjugate base of (2S)-2-hydroxy-2-methyl-3-oxobutanoic acid." []
-is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion
-relationship: is_conjugate_base_of CHEBI:18409 ! (2S)-2-hydroxy-2-methyl-3-oxobutanoic acid
-
[Term]
id: CHEBI:58496
name: N-acetyl-D-amino acid anion
@@ -20934,19 +20678,6 @@ def: "An inorganic radical in which a free electron resides on one or more oxyge
is_a: CHEBI:26523 ! reactive oxygen species
is_a: CHEBI:36871 ! inorganic radical
-[Term]
-id: CHEBI:61078
-name: purine nucleoside bisphosphate
-def: "A nucleoside bisphosphate that has a purine nucleobase." []
-is_a: CHEBI:26401 ! purines
-is_a: CHEBI:37123 ! nucleoside bisphosphate
-
-[Term]
-id: CHEBI:61079
-name: ribonucleoside bisphosphate
-def: "A nucleoside bisphosphate where sugar of the nucleoside is ribose." []
-is_a: CHEBI:37123 ! nucleoside bisphosphate
-
[Term]
id: CHEBI:61109
name: pyrimidine nucleotide-sugar
@@ -23358,13 +23089,6 @@ def: "A dipeptide formed from L-isoleucine and L-valine residues." []
is_a: CHEBI:46761 ! dipeptide
relationship: RO:0000087 CHEBI:25212 ! has role metabolite
-[Term]
-id: CHEBI:74338
-name: D-valine zwitterion
-def: "A D-alpha-amino acid zwitterion that is D-valine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." []
-is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion
-relationship: is_tautomer_of CHEBI:27477 ! D-valine
-
[Term]
id: CHEBI:74389
name: Ala-Leu zwitterion
@@ -24467,12 +24191,6 @@ name: human metabolite
def: "Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens)." []
is_a: CHEBI:75768 ! mammalian metabolite
-[Term]
-id: CHEBI:77881
-name: EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor
-def: "An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of diaminopropionate ammonia-lyase (EC 4.3.1.15)." []
-is_a: CHEBI:76832 ! EC 4.3.1.* (ammonia-lyase) inhibitor
-
[Term]
id: CHEBI:77941
name: EC 3.5.1.4 (amidase) inhibitor
@@ -26097,7 +25815,7 @@ disjoint_from: GO:0032991 ! protein-containing complex
disjoint_from: GO:0043226 ! organelle
relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus
relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus
-relationship: RO:0002160 NCBITaxon:131567 ! only in taxon cellular organisms
+relationship: RO:0002162 NCBITaxon:131567 ! in taxon cellular organisms
[Term]
id: CL:0000005
@@ -26158,6 +25876,7 @@ relationship: RO:0002215 GO:0048137 ! capable of spermatocyte division
id: CL:0000018
name: spermatid
is_a: CL:0000015 ! male germ cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: RO:0000053 PATO:0001375 ! bearer of haploid
@@ -26172,6 +25891,7 @@ relationship: RO:0002215 GO:0007289 ! capable of spermatid nucleus differentiati
[Term]
id: CL:0000019
name: sperm
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000408 ! male gamete
relationship: RO:0002202 CL:0000018 ! develops from spermatid
@@ -26188,6 +25908,7 @@ relationship: RO:0000053 PATO:0001501 ! bearer of immature
[Term]
id: CL:0000021
name: female germ cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000586 ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis
@@ -26205,9 +25926,8 @@ intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division
id: CL:0000023
name: oocyte
is_a: CL:0000021 ! female germ cell
-is_a: CL:0000255 ! eukaryotic cell
relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division
-relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa
+relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
[Term]
id: CL:0000024
@@ -26245,6 +25965,7 @@ relationship: RO:0002202 CL:0002676 ! develops from neural crest derived neurobl
id: CL:0000030
name: glioblast
is_a: CL:0000055 ! non-terminally differentiated cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: RO:0002202 CL:0000133 ! develops from neurectodermal cell
[Term]
@@ -26252,12 +25973,13 @@ id: CL:0000031
name: neuroblast (sensu Vertebrata)
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000255 ! eukaryotic cell
-relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata
+relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata
[Term]
id: CL:0000034
name: stem cell
comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division
@@ -26335,6 +26057,7 @@ name: monoblast
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
+is_a: PR:000050567
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000791 ! has part euchromatin
@@ -26465,7 +26188,8 @@ relationship: RO:0003000 UBERON:0008883 ! produces osteoid
[Term]
id: CL:0000064
name: ciliated cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
+is_a: PR:000050567
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000051 GO:0005929 ! has part cilium
relationship: BFO:0000051 GO:0005929 ! has part cilium
@@ -26474,12 +26198,17 @@ relationship: BFO:0000051 GO:0005929 ! has part cilium
id: CL:0000065
name: ependymal cell
is_a: CL:0000067 ! ciliated epithelial cell
+is_a: CL:0000125 ! glial cell
is_a: CL:0000710 ! neurecto-epithelial cell
+intersection_of: CL:0000710 ! neurecto-epithelial cell
+intersection_of: BFO:0000050 UBERON:0004670 ! part of ependyma
+relationship: BFO:0000050 UBERON:0004670 ! part of ependyma
+relationship: RO:0002207 CL:0000681 ! directly develops from radial glial cell
[Term]
id: CL:0000066
name: epithelial cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
disjoint_from: CL:0000738 ! leukocyte
relationship: BFO:0000050 UBERON:0000483 ! part of epithelium
@@ -26511,7 +26240,6 @@ is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel
relationship: BFO:0000050 UBERON:0004638 ! part of blood vessel endothelium
-relationship: RO:0002202 CL:0002546 ! develops from embryonic blood vessel endothelial progenitor cell
[Term]
id: CL:0000072
@@ -26528,6 +26256,9 @@ is_a: CL:0000066 ! epithelial cell
id: CL:0000076
name: squamous epithelial cell
is_a: CL:0000066 ! epithelial cell
+intersection_of: CL:0000066 ! epithelial cell
+intersection_of: BFO:0000050 UBERON:0006914 ! part of squamous epithelium
+relationship: BFO:0000050 UBERON:0006914 ! part of squamous epithelium
[Term]
id: CL:0000077
@@ -26535,6 +26266,7 @@ name: mesothelial cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
+relationship: BFO:0000050 UBERON:0001136 ! part of mesothelium
[Term]
id: CL:0000079
@@ -26545,7 +26277,7 @@ relationship: RO:0002202 CL:0000357 ! develops from stratified epithelial stem c
[Term]
id: CL:0000080
name: circulating cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid
relationship: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid
@@ -26589,6 +26321,7 @@ id: CL:0000091
name: Kupffer cell
comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
is_a: CL:0000864 ! tissue-resident macrophage
+is_a: PR:000050567
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: RO:0001025 UBERON:0001281 ! located in hepatic sinusoid
intersection_of: RO:0002104 PR:000001813 ! has plasma membrane part adhesion G protein-coupled receptor E1
@@ -26610,6 +26343,7 @@ comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF recept
is_a: CL:0000518 ! phagocyte (sensu Vertebrata)
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0001035 ! bone cell
+is_a: PR:000050567
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element
intersection_of: BFO:0000051 PR:000001850 ! has part cathepsin K
@@ -26635,6 +26369,7 @@ id: CL:0000094
name: granulocyte
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 ! myeloid leukocyte
+is_a: PR:000050567
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000051 GO:0030141 ! has part secretory granule
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
@@ -26666,6 +26401,7 @@ name: mast cell
comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
is_a: CL:0000766 ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
+is_a: PR:000050567
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: BFO:0000051 GO:0030141 ! has part secretory granule
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
@@ -26782,6 +26518,7 @@ id: CL:0000115
name: endothelial cell
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
is_a: CL:0000213 ! lining cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell
[Term]
@@ -26832,8 +26569,7 @@ relationship: RO:0000053 PATO:0070010 ! bearer of stellate morphology
id: CL:0000123
name: neuron associated cell (sensu Vertebrata)
is_a: CL:0000095 ! neuron associated cell
-is_a: CL:0000255 ! eukaryotic cell
-relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata
+relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata
relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
[Term]
@@ -26868,6 +26604,7 @@ id: CL:0000129
name: microglial cell
is_a: CL:0000125 ! glial cell
is_a: CL:0000878 ! central nervous system macrophage
+is_a: PR:000050567
intersection_of: CL:0000125 ! glial cell
intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
@@ -26958,6 +26695,7 @@ is_a: CL:0000325 ! stuff accumulating cell
id: CL:0000148
name: melanocyte
is_a: CL:0000147 ! pigment cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000147 ! pigment cell
intersection_of: BFO:0000051 GO:0042470 ! has part melanosome
intersection_of: RO:0002202 CL:0000541 ! develops from melanoblast
@@ -26988,6 +26726,7 @@ relationship: RO:0002215 GO:0032940 ! capable of secretion by cell
id: CL:0000152
name: exocrine cell
is_a: CL:0000151 ! secretory cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland
relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland
@@ -27054,6 +26793,7 @@ is_a: CL:0000151 ! secretory cell
is_a: CL:0000164 {gci_filler="UBERON:0000945", gci_relation="BFO:0000050"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="BFO:0000050"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="BFO:0000050"} ! enteroendocrine cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system
[Term]
@@ -27090,6 +26830,7 @@ id: CL:0000168
name: insulin secreting cell
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion
relationship: RO:0002215 GO:0030073 ! capable of insulin secretion
@@ -27178,6 +26919,7 @@ relationship: RO:0002202 CL:0009091 ! develops from Leydig stem cell
id: CL:0000179
name: progesterone secreting cell
is_a: CL:0000174 ! steroid hormone secreting cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: RO:0002215 GO:0042701 ! capable of progesterone secretion
relationship: RO:0002215 GO:0042701 ! capable of progesterone secretion
@@ -27223,13 +26965,14 @@ is_a: CL:0002320 ! connective tissue cell
id: CL:0000187
name: muscle cell
is_a: CL:0000183 ! contractile cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000393 ! electrically responsive cell
relationship: RO:0002202 CL:0000056 ! develops from myoblast
[Term]
id: CL:0000188
name: cell of skeletal muscle
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue
relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue
@@ -27257,7 +27000,7 @@ relationship: RO:0002202 CL:0000514 ! develops from smooth muscle myoblast
id: CL:0000197
name: sensory receptor cell
def: "A cell that is capable of detection of a stimulus involved in sensory perception." []
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system
intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception
@@ -27332,10 +27075,11 @@ relationship: RO:0002215 GO:0050912 ! capable of detection of chemical stimulus
[Term]
id: CL:0000210
name: photoreceptor cell
-is_a: CL:0000006 ! neuronal receptor cell
+is_a: CL:0000101 ! sensory neuron
+is_a: CL:0008028 ! visual system neuron
intersection_of: CL:0000540 ! neuron
-intersection_of: RO:0002215 GO:0050962 ! capable of detection of light stimulus involved in sensory perception
-relationship: RO:0002215 GO:0050962 ! capable of detection of light stimulus involved in sensory perception
+intersection_of: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception
+relationship: RO:0002215 GO:0050908 ! capable of detection of light stimulus involved in visual perception
[Term]
id: CL:0000211
@@ -27393,18 +27137,21 @@ relationship: RO:0002215 GO:0048870 ! capable of cell motility
[Term]
id: CL:0000221
name: ectodermal cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm
[Term]
id: CL:0000222
name: mesodermal cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm
[Term]
id: CL:0000223
name: endodermal cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: BFO:0000050 UBERON:0000925 ! part of endoderm
@@ -27420,6 +27167,7 @@ relationship: RO:0000053 PATO:0001405 ! bearer of anucleate
[Term]
id: CL:0000226
name: single nucleate cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001407 ! bearer of mononucleate
@@ -27428,6 +27176,7 @@ relationship: RO:0000053 PATO:0001407 ! bearer of mononucleate
[Term]
id: CL:0000228
name: multinucleate cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
@@ -27517,6 +27266,18 @@ id: CL:0000240
name: stratified squamous epithelial cell
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000079 ! stratified epithelial cell
+intersection_of: CL:0000079 ! stratified epithelial cell
+intersection_of: BFO:0000050 UBERON:0006915 ! part of stratified squamous epithelium
+relationship: BFO:0000050 UBERON:0006915 ! part of stratified squamous epithelium
+
+[Term]
+id: CL:0000241
+name: stratified cuboidal epithelial cell
+is_a: CL:0000075 ! columnar/cuboidal epithelial cell
+is_a: CL:0000079 ! stratified epithelial cell
+intersection_of: CL:0000079 ! stratified epithelial cell
+intersection_of: BFO:0000050 UBERON:0010077 ! part of cuboidal epithelium
+relationship: BFO:0000050 UBERON:0010077 ! part of cuboidal epithelium
[Term]
id: CL:0000242
@@ -27536,20 +27297,21 @@ id: CL:0000255
name: eukaryotic cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
-intersection_of: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota
-relationship: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota
+intersection_of: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
+relationship: RO:0002162 NCBITaxon:2759 ! in taxon Eukaryota
[Term]
id: CL:0000257
name: Eumycetozoan cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
-intersection_of: RO:0002160 NCBITaxon:142796 ! only in taxon Eumycetozoa
-relationship: RO:0002160 NCBITaxon:142796 ! only in taxon Eumycetozoa
+intersection_of: RO:0002162 NCBITaxon:142796 ! in taxon Eumycetozoa
+relationship: RO:0002162 NCBITaxon:142796 ! in taxon Eumycetozoa
[Term]
id: CL:0000287
name: eye photoreceptor cell
+is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: BFO:0000050 UBERON:0000970 ! part of eye
@@ -27640,8 +27402,10 @@ relationship: RO:0002215 GO:0070254 ! capable of mucus secretion
[Term]
id: CL:0000322
name: pulmonary alveolar epithelial cell
+is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000082 ! epithelial cell of lung
-is_a: CL:0010003 ! epithelial cell of alveolus of lung
+intersection_of: CL:0000066 ! epithelial cell
+intersection_of: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium
relationship: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium
[Term]
@@ -27716,6 +27480,7 @@ relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
[Term]
id: CL:0000347
name: scleral cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000293 ! structural cell
intersection_of: CL:0000293 ! structural cell
intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera
@@ -27725,6 +27490,7 @@ relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural cre
[Term]
id: CL:0000348
name: choroidal cell of the eye
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000293 ! structural cell
intersection_of: CL:0000293 ! structural cell
intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid
@@ -27734,7 +27500,7 @@ relationship: RO:0002202 CL:0000008 ! develops from migratory cranial neural cre
[Term]
id: CL:0000349
name: extraembryonic cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure
relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure
@@ -27806,8 +27572,8 @@ is_a: CL:0000007 ! early embryonic cell (metazoa)
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0010017 ! zygote
intersection_of: CL:0010017 ! zygote
-intersection_of: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa
-relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa
+intersection_of: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
+relationship: RO:0002162 NCBITaxon:33208 ! in taxon Metazoa
[Term]
id: CL:0000377
@@ -27829,7 +27595,7 @@ id: CL:0000387
name: hemocyte (sensu Arthropoda)
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)
-relationship: RO:0002160 NCBITaxon:6656 ! only in taxon Arthropoda
+relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda
relationship: RO:0002202 CL:0000385 ! develops from prohemocyte (sensu Nematoda and Protostomia)
[Term]
@@ -27948,8 +27714,7 @@ relationship: RO:0002215 GO:0036160 ! capable of melanocyte-stimulating hormone
id: CL:0000441
name: follicle stem cell (sensu Arthropoda)
is_a: CL:0000036 ! epithelial fate stem cell
-is_a: CL:0000255 ! eukaryotic cell
-relationship: RO:0002160 NCBITaxon:6656 ! only in taxon Arthropoda
+relationship: RO:0002162 NCBITaxon:6656 ! in taxon Arthropoda
[Term]
id: CL:0000442
@@ -27995,6 +27760,7 @@ id: CL:0000451
name: dendritic cell
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
+is_a: PR:000050567
intersection_of: CL:0000738 ! leukocyte
intersection_of: BFO:0000051 GO:0042613 ! has part MHC class II protein complex
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
@@ -28103,10 +27869,9 @@ relationship: RO:0002215 GO:0070460 ! capable of thyroid-stimulating hormone sec
id: CL:0000477
name: follicle cell of egg chamber
def: "A somatic epithelial cell of the insect egg chamber." []
-is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000500 ! follicular epithelial cell
is_a: CL:2000064 ! ovarian surface epithelial cell
-relationship: RO:0002160 NCBITaxon:50557 ! only in taxon Insecta
+relationship: RO:0002162 NCBITaxon:50557 ! in taxon Insecta
relationship: RO:0002202 CL:0000441 ! develops from follicle stem cell (sensu Arthropoda)
[Term]
@@ -28158,7 +27923,7 @@ id: CL:0000501
name: granulosa cell
is_a: CL:0000174 ! steroid hormone secreting cell
is_a: CL:0002174 ! follicular cell of ovary
-relationship: RO:0002207 CL:4033066 ! directly develops from pre-granulosa cell
+relationship: RO:0002202 CL:4033066 ! develops from pre-granulosa cell
[Term]
id: CL:0000502
@@ -28241,6 +28006,7 @@ relationship: RO:0002203 CL:0008002 ! develops into skeletal muscle fiber
[Term]
id: CL:0000517
name: macrophage derived foam cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000891 ! foam cell
relationship: RO:0002202 CL:0000235 ! develops from macrophage
@@ -28249,21 +28015,21 @@ id: CL:0000518
name: phagocyte (sensu Vertebrata)
is_a: CL:0000234 ! phagocyte
is_a: CL:0000255 ! eukaryotic cell
-relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata
+relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata
[Term]
id: CL:0000521
name: fungal cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
-intersection_of: RO:0002160 NCBITaxon:4751 ! only in taxon Fungi
-relationship: RO:0002160 NCBITaxon:4751 ! only in taxon Fungi
+intersection_of: RO:0002162 NCBITaxon:4751 ! in taxon Fungi
+relationship: RO:0002162 NCBITaxon:4751 ! in taxon Fungi
[Term]
id: CL:0000525
name: syncytiotrophoblast cell
-is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell
+is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
relationship: BFO:0000050 UBERON:0000371 ! part of syncytiotrophoblast
@@ -28350,6 +28116,7 @@ id: CL:0000547
name: proerythroblast
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
+is_a: PR:000050567
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0005730 ! has part nucleolus
@@ -28388,6 +28155,7 @@ relationship: RO:0002202 CL:0000038 ! develops from erythroid progenitor cell
id: CL:0000549
name: basophilic erythroblast
is_a: CL:0000765 ! erythroblast
+is_a: PR:000050567
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm
intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin
@@ -28400,6 +28168,7 @@ relationship: RO:0002104 PR:000001945 ! has plasma membrane part transferrin rec
id: CL:0000550
name: polychromatophilic erythroblast
is_a: CL:0000765 ! erythroblast
+is_a: PR:000050567
intersection_of: CL:0000765 ! erythroblast
intersection_of: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm
intersection_of: BFO:0000051 GO:0000792 ! has part heterochromatin
@@ -28479,6 +28248,7 @@ is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:0011026 ! progenitor cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
+is_a: PR:000050567
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow
intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
@@ -28500,6 +28270,7 @@ relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation
id: CL:0000558
name: reticulocyte
is_a: CL:0000764 ! erythroid lineage cell
+is_a: PR:000050567
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -28535,6 +28306,7 @@ name: promonocyte
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 ! monopoietic cell
+is_a: PR:000050567
intersection_of: CL:0002194 ! monopoietic cell
intersection_of: BFO:0000051 GO:0042582 ! has part azurophil granule
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
@@ -28568,6 +28340,7 @@ name: angioblastic mesenchymal cell
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
@@ -28602,6 +28375,7 @@ name: parafollicular cell
is_a: CL:0000443 ! calcitonin secreting cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000710 ! neurecto-epithelial cell
+is_a: PR:000050567
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1
intersection_of: RO:0002215 GO:0001820 ! capable of serotonin secretion
@@ -28649,6 +28423,7 @@ id: CL:0000581
name: peritoneal macrophage
comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+.
is_a: CL:0000864 ! tissue-resident macrophage
+is_a: PR:000050567
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
intersection_of: RO:0001025 UBERON:0001179 ! located in peritoneal cavity
@@ -28675,6 +28450,7 @@ name: alveolar macrophage
comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:1001603 ! lung macrophage
+is_a: PR:000050567
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part CX3C chemokine receptor 1
intersection_of: RO:0001025 UBERON:8850000 ! located in lumen of pulmonary alveolus
@@ -28781,6 +28557,7 @@ name: eosinophil progenitor cell
comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76).
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
+is_a: PR:000050567
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
@@ -28832,6 +28609,7 @@ name: basophil progenitor cell
comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf).
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
+is_a: PR:000050567
intersection_of: CL:0002191 ! granulocytopoietic cell
intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor
@@ -28959,6 +28737,7 @@ name: hepatic stellate cell
comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
is_a: CL:0000057 ! fibroblast
is_a: CL:0000327 ! extracellular matrix secreting cell
+is_a: PR:000050567
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: BFO:0000050 UBERON:0002107 ! part of liver
intersection_of: RO:0002104 PR:000007939 ! has plasma membrane part glial fibrillary acidic protein
@@ -29103,6 +28882,7 @@ relationship: RO:0002202 CL:0000654 ! develops from primary oocyte
id: CL:0000656
name: primary spermatocyte
is_a: CL:0000017 ! spermatocyte
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: RO:0000053 PATO:0001394 ! bearer of diploid
intersection_of: RO:0002215 GO:0007140 ! capable of male meiotic nuclear division
@@ -29113,6 +28893,7 @@ relationship: RO:0002215 GO:0007140 ! capable of male meiotic nuclear division
id: CL:0000657
name: secondary spermatocyte
is_a: CL:0000017 ! spermatocyte
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: RO:0000053 PATO:0001375 ! bearer of haploid
@@ -29161,7 +28942,7 @@ is_a: CL:0000300 ! gamete
[Term]
id: CL:0000677
name: gut absorptive cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium
[Term]
@@ -29178,6 +28959,7 @@ relationship: RO:0002215 GO:0061535 ! capable of glutamate secretion, neurotrans
id: CL:0000680
name: muscle precursor cell
is_a: CL:0000055 ! non-terminally differentiated cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: RO:0002203 CL:0000187 ! develops into muscle cell
relationship: RO:0002202 CL:0000222 ! develops from mesodermal cell
@@ -29190,6 +28972,16 @@ comment: Unlike that of mammals, the brain of adult teleost fish exhibits an int
is_a: CL:0000125 ! glial cell
relationship: RO:0002202 CL:0000710 ! develops from neurecto-epithelial cell
+[Term]
+id: CL:0000686
+name: cerebrospinal fluid secreting cell
+is_a: CL:0000151 ! secretory cell
+is_a: CL:0000710 ! neurecto-epithelial cell
+intersection_of: CL:0000151 ! secretory cell
+intersection_of: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion
+relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
+relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion
+
[Term]
id: CL:0000691
name: stellate interneuron
@@ -29230,11 +29022,12 @@ is_a: CL:0000630 ! supporting cell
id: CL:0000706
name: choroid plexus epithelial cell
is_a: CL:0000065 ! ependymal cell
+is_a: CL:0000239 ! brush border epithelial cell
is_a: CL:0000627 ! transporting cell
-is_a: CL:0002319 ! neural cell
intersection_of: CL:0000065 ! ependymal cell
-intersection_of: BFO:0000050 UBERON:0001886 ! part of choroid plexus
-relationship: BFO:0000050 UBERON:0001886 ! part of choroid plexus
+intersection_of: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium
+relationship: BFO:0000050 UBERON:0003911 ! part of choroid plexus epithelium
+relationship: RO:0002215 GO:0033326 ! capable of cerebrospinal fluid secretion
[Term]
id: CL:0000708
@@ -29301,7 +29094,7 @@ intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0002505 ! bearer of nucleated
intersection_of: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration
relationship: BFO:0000050 UBERON:0002405 ! part of immune system
-relationship: RO:0002160 NCBITaxon:7742 ! only in taxon Vertebrata
+relationship: RO:0002162 NCBITaxon:7742 ! in taxon Vertebrata
relationship: RO:0002202 CL:0000037 ! develops from hematopoietic stem cell
relationship: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration
@@ -29351,13 +29144,11 @@ is_a: CL:0000748 ! retinal bipolar neuron
[Term]
id: CL:0000751
name: rod bipolar cell
-is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000749 ! ON-bipolar cell
relationship: BFO:0000050 RO:0002577 ! part of system
relationship: RO:0002102 UBERON:0008925 ! axon synapses in sublaminar layer S4
relationship: RO:0002102 UBERON:0008926 ! axon synapses in sublaminar layer S5
relationship: RO:0002103 CL:0000604 ! synapsed by retinal rod cell
-relationship: RO:0002160 NCBITaxon:40674 ! only in taxon Mammalia
[Term]
id: CL:0000752
@@ -29383,6 +29174,7 @@ relationship: RO:0002215 GO:0007596 ! capable of blood coagulation
[Term]
id: CL:0000763
name: myeloid cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0002202 CL:0000049 ! develops from common myeloid progenitor
@@ -29508,6 +29300,7 @@ name: multinuclear osteoclast
comment: Morphology: multinucleated, highly vesicular.
is_a: CL:0000092 ! osteoclast
is_a: CL:0000783 ! multinucleated phagocyte
+is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000092 ! osteoclast
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
relationship: RO:0002202 CL:0000778 ! develops from mononuclear osteoclast
@@ -29581,6 +29374,7 @@ id: CL:0000786
name: plasma cell
comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
is_a: CL:0000946 ! antibody secreting cell
+is_a: PR:000050567
intersection_of: CL:0000946 ! antibody secreting cell
intersection_of: BFO:0000051 CL:0017508 ! has part cartwheel heterochromatin
intersection_of: BFO:0000051 GO:0005794 ! has part Golgi apparatus
@@ -29632,6 +29426,7 @@ relationship: RO:0002104 PR:000001289 ! has plasma membrane part membrane-spanni
id: CL:0000789
name: alpha-beta T cell
is_a: CL:0000084 ! T cell
+is_a: PR:000050567
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex
disjoint_from: CL:0000798 ! gamma-delta T cell
@@ -29725,6 +29520,7 @@ id: CL:0000798
name: gamma-delta T cell
comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways.
is_a: CL:0000084 ! T cell
+is_a: PR:000050567
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
relationship: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
@@ -29782,6 +29578,7 @@ id: CL:0000805
name: immature single positive thymocyte
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages.
is_a: CL:0000893 ! thymocyte
+is_a: PR:000050567
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule
@@ -29802,6 +29599,7 @@ id: CL:0000806
name: DN2 thymocyte
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
is_a: CL:0002489 ! double negative thymocyte
+is_a: PR:000050567
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000025402 ! lacks_plasma_membrane_part T cell receptor co-receptor CD8
@@ -29816,6 +29614,7 @@ id: CL:0000807
name: DN3 thymocyte
comment: There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
is_a: CL:0002489 ! double negative thymocyte
+is_a: PR:000050567
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule
@@ -29832,6 +29631,7 @@ id: CL:0000808
name: DN4 thymocyte
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
is_a: CL:0002489 ! double negative thymocyte
+is_a: PR:000050567
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001307 ! lacks_plasma_membrane_part CD44 molecule
@@ -30031,6 +29831,7 @@ id: CL:0000825
name: pro-NK cell
comment: Most markers only described for human pro NK cells.
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: CL:4030046 PR:000001874 ! lacks_plasma_membrane_part KLRB1-like protein
intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
@@ -30051,6 +29852,7 @@ id: CL:0000826
name: pro-B cell
comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: BFO:0000051 PR:000001903 ! has part paired box protein PAX-5
intersection_of: BFO:0000051 PR:000006611 ! has part DNA nucleotidylexotransferase
@@ -30097,6 +29899,7 @@ name: mast cell progenitor
comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor
intersection_of: BFO:0000051 PR:000007858 ! has part endothelial transcription factor GATA-2
@@ -30187,7 +29990,9 @@ relationship: RO:0002202 CL:0000557 ! develops from granulocyte monocyte progeni
id: CL:0000837
name: hematopoietic multipotent progenitor cell
comment: Markers differ between mouse and human.
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
+is_a: PR:000050567
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -30376,6 +30181,7 @@ id: CL:0000860
name: classical monocyte
comment: Markers: CCR2+CXCCR1 (human, mouse, rat).
is_a: CL:0000576 ! monocyte
+is_a: PR:000050567
intersection_of: CL:0000576 ! monocyte
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
@@ -30396,6 +30202,7 @@ id: CL:0000861
name: elicited macrophage
comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).
is_a: CL:0000235 ! macrophage
+is_a: PR:000050567
intersection_of: CL:0000235 ! macrophage
intersection_of: RO:0000056 GO:0006954 ! participates in inflammatory response
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
@@ -30442,6 +30249,7 @@ id: CL:0000868
name: lymph node macrophage
comment: Marker was observed on rat cells.
is_a: CL:0000867 ! secondary lymphoid organ macrophage
+is_a: PR:000050567
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
intersection_of: BFO:0000050 UBERON:0000029 ! part of lymph node
intersection_of: RO:0015015 PR:000001931 ! has high plasma membrane amount sialoadhesin
@@ -30486,6 +30294,7 @@ id: CL:0000872
name: splenic marginal zone macrophage
comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+.
is_a: CL:0000871 ! splenic macrophage
+is_a: PR:000050567
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
@@ -30505,6 +30314,7 @@ id: CL:0000873
name: splenic metallophillic macrophage
comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+.
is_a: CL:0000871 ! splenic macrophage
+is_a: PR:000050567
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: BFO:0000050 UBERON:0001251 ! part of marginal zone of spleen
intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1
@@ -30522,6 +30332,7 @@ id: CL:0000874
name: splenic red pulp macrophage
comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes.
is_a: CL:0000871 ! splenic macrophage
+is_a: PR:000050567
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: BFO:0000050 UBERON:0001250 ! part of red pulp of spleen
intersection_of: CL:4030046 PR:000001013 ! lacks_plasma_membrane_part integrin alpha-X
@@ -30548,6 +30359,7 @@ id: CL:0000876
name: splenic white pulp macrophage
comment: Markers: Mouse: F4/80-, CD68+, macrosialin+.
is_a: CL:0000871 ! splenic macrophage
+is_a: PR:000050567
intersection_of: CL:0000871 ! splenic macrophage
intersection_of: BFO:0000050 UBERON:0001959 ! part of white pulp of spleen
intersection_of: CL:4030046 PR:000001813 ! lacks_plasma_membrane_part adhesion G protein-coupled receptor E1
@@ -30570,6 +30382,7 @@ id: CL:0000881
name: perivascular macrophage
is_a: CL:4033054 ! perivascular cell
is_a: CL:4042003 ! border associated macrophage
+is_a: PR:000050567
intersection_of: CL:4042003 ! border associated macrophage
intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel
intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
@@ -30625,6 +30438,7 @@ id: CL:0000889
name: myeloid suppressor cell
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
is_a: CL:0000766 ! myeloid leukocyte
+is_a: PR:000050567
intersection_of: CL:0000766 ! myeloid leukocyte
intersection_of: RO:0000053 PATO:0001501 ! bearer of immature
intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
@@ -30653,6 +30467,7 @@ relationship: BFO:0000050 UBERON:0002370 ! part of thymus
id: CL:0000894
name: DN1 thymic pro-T cell
is_a: CL:0000827 ! pro-T cell
+is_a: PR:000050567
intersection_of: CL:0000827 ! pro-T cell
intersection_of: BFO:0000050 UBERON:0002370 ! part of thymus
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -31175,6 +30990,7 @@ id: CL:0000937
name: pre-natural killer cell
comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.
is_a: CL:0000623 ! natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000623 ! natural killer cell
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001381 ! has plasma membrane part interleukin-2 receptor subunit beta
@@ -31188,6 +31004,7 @@ id: CL:0000939
name: CD16-positive, CD56-dim natural killer cell, human
comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+CD56+ NK cell'. Markers are associated with human cell types.
is_a: CL:0000824 ! mature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: CL:4030046 PR:000002015 ! lacks_plasma_membrane_part MHC class II histocompatibility antigen alpha chain DRA
intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III
@@ -31926,6 +31743,7 @@ id: CL:0001008
name: Kit and Sca1-positive hematopoietic stem cell
comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617).
is_a: CL:0000037 ! hematopoietic stem cell
+is_a: PR:000050567
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
@@ -32003,6 +31821,7 @@ name: CD34-positive, CD38-positive common lymphoid progenitor
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
+is_a: PR:000050567
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001015 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RA
@@ -32022,6 +31841,7 @@ comment: These markers are associated with human cells. Originally described in
is_a: CL:0000576 ! monocyte
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
+is_a: PR:000050567
intersection_of: CL:0000576 ! monocyte
intersection_of: RO:0002104 PR:000001012 ! has plasma membrane part integrin alpha-M
intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor
@@ -32054,6 +31874,7 @@ id: CL:0001024
name: CD34-positive, CD38-negative hematopoietic stem cell
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).
is_a: CL:0000037 ! hematopoietic stem cell
+is_a: PR:000050567
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001408 ! lacks_plasma_membrane_part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
@@ -32079,6 +31900,7 @@ name: Kit-positive, Sca1-positive common lymphoid progenitor
comment: Markers are associated with mouse cells.
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
+is_a: PR:000050567
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
@@ -32123,6 +31945,7 @@ name: CD7-negative lymphoid progenitor cell
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).
is_a: CL:0000051 ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
+is_a: PR:000050567
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001836 ! lacks_plasma_membrane_part CD7 molecule
@@ -32137,6 +31960,7 @@ id: CL:0001028
name: CD7-positive lymphoid progenitor cell
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).
is_a: CL:0000051 ! common lymphoid progenitor
+is_a: PR:000050567
intersection_of: CL:0000051 ! common lymphoid progenitor
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
@@ -32152,6 +31976,7 @@ name: common dendritic progenitor
comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
+is_a: PR:000050567
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -32223,7 +32048,7 @@ intersection_of: RO:0002100 UBERON:0002421 ! has soma location hippocampal forma
[Term]
id: CL:0001035
name: bone cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element
relationship: BFO:0000050 UBERON:0001474 ! part of bone element
@@ -32339,6 +32164,7 @@ id: CL:0001054
name: CD14-positive monocyte
comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.
is_a: CL:0000576 ! monocyte
+is_a: PR:000050567
intersection_of: CL:0000576 ! monocyte
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
@@ -32397,6 +32223,7 @@ name: common myeloid progenitor, CD34-positive
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
is_a: CL:0000049 ! common myeloid progenitor
is_a: CL:0011026 ! progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000049 ! common myeloid progenitor
intersection_of: BFO:0000051 PR:000001944 ! has part transcription factor PU.1
intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
@@ -32506,6 +32333,7 @@ relationship: RO:0002215 GO:0045087 ! capable of innate immune response
id: CL:0001066
name: erythroid progenitor cell, mammalian
is_a: CL:0000038 ! erythroid progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000038 ! erythroid progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -32560,6 +32388,7 @@ relationship: BFO:0000050 UBERON:0001347 ! part of white adipose tissue
id: CL:0001071
name: group 3 innate lymphoid cell
is_a: CL:0001065 ! innate lymphoid cell
+is_a: PR:000050567
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2
relationship: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma isoform 2
@@ -32568,6 +32397,7 @@ relationship: BFO:0000051 PR:000003455 ! has part nuclear receptor ROR-gamma iso
id: CL:0001072
name: CD34-negative, CD117-positive innate lymphoid cell, human
is_a: CL:0001082 ! immature innate lymphoid cell
+is_a: PR:000050567
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: CL:4030046 PR:P28906 ! lacks_plasma_membrane_part hematopoietic progenitor cell antigen CD34 (human)
intersection_of: RO:0000053 PATO:0001501 ! bearer of immature
@@ -32592,6 +32422,7 @@ relationship: RO:0002104 PR:P13591 ! has plasma membrane part neural cell adhesi
id: CL:0001074
name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human
is_a: CL:0001082 ! immature innate lymphoid cell
+is_a: PR:000050567
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: RO:0000053 PATO:0001501 ! bearer of immature
intersection_of: RO:0002104 PR:P10721 ! has plasma membrane part mast/stem cell growth factor receptor Kit (human)
@@ -32644,6 +32475,7 @@ id: CL:0001200
name: lymphocyte of B lineage, CD19-positive
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
is_a: CL:0000945 ! lymphocyte of B lineage
+is_a: PR:000050567
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
@@ -32659,7 +32491,6 @@ is_a: CL:0000236 ! B cell
is_a: CL:0001200 ! lymphocyte of B lineage, CD19-positive
intersection_of: CL:0001200 ! lymphocyte of B lineage, CD19-positive
intersection_of: RO:0002104 PR:000001002 ! has plasma membrane part CD19 molecule
-intersection_of: RO:0002162 NCBITaxon:40674 ! in taxon Mammalia
intersection_of: RO:0002215 GO:0019724 ! capable of B cell mediated immunity
[Term]
@@ -32678,14 +32509,14 @@ intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell
intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
intersection_of: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
-intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens
+intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens
intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation
intersection_of: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule
intersection_of: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta
relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
relationship: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
-relationship: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens
+relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens
relationship: RO:0002202 CL:0000906 ! develops from activated CD8-positive, alpha-beta T cell
relationship: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule
relationship: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta
@@ -32698,14 +32529,14 @@ intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell
intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
intersection_of: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO
intersection_of: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
-intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens
+intersection_of: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens
intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation
intersection_of: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule
intersection_of: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta
relationship: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
relationship: RO:0002104 PR:000001017 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C isoform CD45RO
relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
-relationship: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens
+relationship: RO:0002162 NCBITaxon:9606 ! in taxon Homo sapiens
relationship: RO:0002202 CL:0000896 ! develops from activated CD4-positive, alpha-beta T cell
relationship: RO:0015015 PR:000001307 ! has high plasma membrane amount CD44 molecule
relationship: RO:0015015 PR:000001381 ! has high plasma membrane amount interleukin-2 receptor subunit beta
@@ -32800,6 +32631,7 @@ id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
comment: Markers are associated with human cell type.
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RA
intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
@@ -32815,6 +32647,7 @@ id: CL:0002006
name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
comment: Markers are associated with mouse cells.
is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001479 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor II
@@ -32875,6 +32708,7 @@ id: CL:0002010
name: pre-conventional dendritic cell
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell
+is_a: PR:000050567
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: CL:4030046 GO:0042613 ! lacks_plasma_membrane_part MHC class II protein complex
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
@@ -32915,6 +32749,7 @@ id: CL:0002011
name: Kit-positive macrophage dendritic cell progenitor
comment: Markers are associated with mouse cells.
is_a: CL:0002009 ! macrophage dendritic cell progenitor
+is_a: PR:000050567
intersection_of: CL:0002009 ! macrophage dendritic cell progenitor
intersection_of: RO:0002104 PR:000001206 ! has plasma membrane part CX3C chemokine receptor 1
intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
@@ -33004,6 +32839,7 @@ id: CL:0002017
name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts
comment: Cell surface markers associated with mouse cells.
is_a: CL:0000552 ! orthochromatic erythroblast
+is_a: PR:000050567
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000002065 ! lacks_plasma_membrane_part mast/stem cell growth factor receptor
@@ -33022,6 +32858,7 @@ id: CL:0002018
name: CD71-negative, GlyA-positive orthochromatic erythroblast
comment: Markers associated with human cells.
is_a: CL:0000552 ! orthochromatic erythroblast
+is_a: PR:000050567
intersection_of: CL:0000552 ! orthochromatic erythroblast
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
@@ -33054,6 +32891,7 @@ id: CL:0002021
name: GlyA-positive erythrocyte
comment: Marker is associated with human cell types.
is_a: CL:0000595 ! enucleate erythrocyte
+is_a: PR:000050567
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
relationship: RO:0002104 PR:000001460 ! has plasma membrane part glycophorin-A
@@ -33064,6 +32902,7 @@ id: CL:0002022
name: Ly-76 high positive erythrocyte
comment: Marker is associated with mouse cell types.
is_a: CL:0000595 ! enucleate erythrocyte
+is_a: PR:000050567
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse)
relationship: RO:0002202 CL:0002019 ! develops from Ly-76 high reticulocyte
@@ -33074,6 +32913,7 @@ id: CL:0002023
name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell
comment: Markers are associated with human cell type.
is_a: CL:0000553 ! megakaryocyte progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
intersection_of: RO:0002104 PR:000001907 ! has plasma membrane part platelet glycoprotein Ib alpha chain
@@ -33088,6 +32928,7 @@ id: CL:0002024
name: Kit-positive megakaryocyte progenitor cell
comment: Markers are associated with mouse cells.
is_a: CL:0000553 ! megakaryocyte progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part SLAM family member 1
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
@@ -33110,6 +32951,7 @@ id: CL:0002025
name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell
comment: Markers are commonly associated with human cells.
is_a: CL:0000553 ! megakaryocyte progenitor cell
+is_a: PR:000050567
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
intersection_of: CL:4030046 PR:000001907 ! lacks_plasma_membrane_part platelet glycoprotein Ib alpha chain
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
@@ -33124,6 +32966,7 @@ id: CL:0002026
name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell
comment: Markers are commonly associated with human cells.
is_a: CL:0000556 ! megakaryocyte
+is_a: PR:000050567
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: RO:0002104 PR:000001907 ! has plasma membrane part platelet glycoprotein Ib alpha chain
@@ -33138,6 +32981,7 @@ id: CL:0002027
name: CD9-positive, CD41-positive megakaryocyte cell
comment: Markers are commonly associated with mouse cells.
is_a: CL:0000556 ! megakaryocyte
+is_a: PR:000050567
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: RO:0002104 PR:000005178 ! has plasma membrane part CD9 molecule
intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb
@@ -33151,6 +32995,7 @@ name: basophil mast progenitor cell
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
+is_a: PR:000050567
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: BFO:0000051 PR:000005307 ! has part CCAAT/enhancer-binding protein alpha
intersection_of: BFO:0000051 PR:000007857 ! has part erythroid transcription factor
@@ -33202,6 +33047,7 @@ relationship: RO:0002202 CL:0002044 ! develops from Kit-positive, integrin beta7
[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001400 ! bearer of unipotent
@@ -33213,6 +33059,7 @@ relationship: RO:0002202 CL:0002032 ! develops from hematopoietic oligopotent pr
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: RO:0000053 PATO:0001401 ! bearer of oligopotent
@@ -34197,7 +34044,6 @@ name: ciliated columnar cell of tracheobronchial tree
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0005012 ! multi-ciliated epithelial cell
is_a: CL:4030034 ! respiratory ciliated cell
-relationship: BFO:0000051 GO:0031514 ! has part motile cilium
relationship: RO:0002202 CL:0002209 ! develops from intermediate epitheliocyte
[Term]
@@ -34230,6 +34076,7 @@ relationship: BFO:0000050 UBERON:0012252 ! part of endocervical epithelium
id: CL:0002153
name: corneocyte
is_a: CL:0000225 ! anucleate cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000311 ! keratin accumulating cell
relationship: BFO:0000050 UBERON:0002027 ! part of stratum corneum of epidermis
relationship: RO:0002202 CL:0000312 ! develops from keratinocyte
@@ -34307,6 +34154,8 @@ id: CL:0002174
name: follicular cell of ovary
is_a: CL:0000500 ! follicular epithelial cell
is_a: CL:0002078 ! meso-epithelial cell
+is_a: CL:2000064 ! ovarian surface epithelial cell
+relationship: BFO:0000050 UBERON:0001305 ! part of ovarian follicle
[Term]
id: CL:0002177
@@ -34380,6 +34229,7 @@ id: CL:0002188
name: glomerular endothelial cell
is_a: CL:0000666 ! fenestrated endothelial cell
is_a: CL:0002681 ! kidney cortical cell
+is_a: PR:000050567
intersection_of: CL:0000115 ! endothelial cell
intersection_of: BFO:0000050 UBERON:0000074 ! part of renal glomerulus
relationship: BFO:0000050 UBERON:0000074 ! part of renal glomerulus
@@ -34883,7 +34733,7 @@ relationship: BFO:0000050 UBERON:0001862 ! part of vestibular labyrinth
[Term]
id: CL:0002319
name: neural cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system
relationship: BFO:0000050 UBERON:0001016 ! part of nervous system
@@ -34891,7 +34741,7 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system
[Term]
id: CL:0002320
name: connective tissue cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue
relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue
@@ -34962,7 +34812,7 @@ name: ciliated cell of the bronchus
is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree
is_a: CL:0002328 ! bronchial epithelial cell
intersection_of: CL:0000064 ! ciliated cell
-intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus
+intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus
[Term]
id: CL:0002333
@@ -34992,6 +34842,7 @@ id: CL:0002338
name: CD56-positive, CD161-positive immature natural killer cell, human
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
is_a: CL:0000823 ! immature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adhesion molecule 1
@@ -35024,6 +34875,7 @@ is_a: CL:0002231 ! epithelial cell of prostate
id: CL:0002343
name: decidual natural killer cell, human
is_a: CL:0000824 ! mature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
intersection_of: RO:0002104 PR:000009766 ! has plasma membrane part galectin-1
@@ -35039,6 +34891,7 @@ id: CL:0002344
name: CD56-negative, CD161-positive immature natural killer cell, human
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
is_a: CL:0000823 ! immature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
@@ -35058,6 +34911,7 @@ id: CL:0002345
name: CD27-low, CD11b-low immature natural killer cell, mouse
comment: Markers are associated with mouse cells.
is_a: CL:0000823 ! immature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: RO:0002104 PR:000001008 ! has plasma membrane part integrin alpha-2
intersection_of: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C
@@ -35077,6 +34931,7 @@ relationship: RO:0015016 PR:000001963 ! has low plasma membrane amount CD27 mole
id: CL:0002346
name: Dx5-negative, NK1.1-positive immature natural killer cell, mouse
is_a: CL:0000823 ! immature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001008 ! lacks_plasma_membrane_part integrin alpha-2
intersection_of: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C
@@ -35089,6 +34944,7 @@ relationship: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus
id: CL:0002347
name: CD27-high, CD11b-high natural killer cell, mouse
is_a: CL:0000824 ! mature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus
intersection_of: RO:0002215 GO:0032609 ! capable of type II interferon production
@@ -35103,6 +34959,7 @@ relationship: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 mol
id: CL:0002348
name: CD27-low, CD11b-high natural killer cell, mouse
is_a: CL:0000824 ! mature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus
intersection_of: RO:0015015 PR:000001012 ! has high plasma membrane amount integrin alpha-M
@@ -35116,6 +34973,7 @@ relationship: RO:0015016 PR:000001963 ! has low plasma membrane amount CD27 mole
id: CL:0002349
name: CD27-high, CD11b-low natural killer cell, mouse
is_a: CL:0000824 ! mature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus
intersection_of: RO:0015015 PR:000001963 ! has high plasma membrane amount CD27 molecule
@@ -35150,6 +35008,7 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo
id: CL:0002353
name: fetal liver hematopoietic progenitor cell
is_a: CL:0002352 ! gestational hematopoietic stem cell
+is_a: PR:000050567
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:4030046 PR:000001308 ! lacks_plasma_membrane_part CD48 molecule
intersection_of: CL:4030046 PR:000001896 ! lacks_plasma_membrane_part natural killer cell receptor 2B4
@@ -35173,6 +35032,7 @@ relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte anti
id: CL:0002354
name: yolk sac hematopoietic stem cell
is_a: CL:0002352 ! gestational hematopoietic stem cell
+is_a: PR:000050567
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:4030046 GO:0042611 ! lacks_plasma_membrane_part MHC protein complex
intersection_of: CL:4030046 PR:000001006 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C
@@ -35192,6 +35052,7 @@ relationship: RO:0002104 PR:000002037 ! has plasma membrane part complement comp
id: CL:0002355
name: primitive red blood cell
is_a: CL:0002417 ! primitive erythroid lineage cell
+is_a: PR:000050567
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo
intersection_of: BFO:0000051 PR:000008467 ! has part hemoglobin subunit zeta
@@ -35217,6 +35078,7 @@ relationship: RO:0002202 CL:0002355 ! develops from primitive red blood cell
id: CL:0002357
name: fetal derived definitive erythrocyte
is_a: CL:0000595 ! enucleate erythrocyte
+is_a: PR:000050567
intersection_of: CL:0000595 ! enucleate erythrocyte
intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo
intersection_of: BFO:0000051 PR:000008857 ! has part hemoglobin subunit beta-1
@@ -35246,6 +35108,7 @@ relationship: BFO:0000050 UBERON:0001987 ! part of placenta
id: CL:0002361
name: primitive erythroid progenitor
is_a: CL:0002417 ! primitive erythroid lineage cell
+is_a: PR:000050567
intersection_of: CL:0002417 ! primitive erythroid lineage cell
intersection_of: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb
relationship: RO:0002104 PR:000009127 ! has plasma membrane part integrin alpha-IIb
@@ -35317,8 +35180,8 @@ intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epitheli
[Term]
id: CL:0002372
name: myotube
-is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000737 ! striated muscle cell
+is_a: CL:4052002 ! syncytial cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere
intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
@@ -35337,9 +35200,10 @@ relationship: BFO:0000050 UBERON:0001690 ! part of ear
[Term]
id: CL:0002375
name: Schwann cell precursor
-is_a: CL:0000030 ! glioblast
is_a: CL:0011026 ! progenitor cell
+relationship: RO:0000053 PATO:0001402 ! bearer of multipotent
relationship: RO:0002202 CL:0000333 ! develops from migratory neural crest cell
+relationship: RO:0002387 CL:0002573 ! has potential to develop into Schwann cell
[Term]
id: CL:0002377
@@ -35489,6 +35353,7 @@ relationship: RO:0002202 CL:0002354 ! develops from yolk sac hematopoietic stem
id: CL:0002419
name: mature T cell
is_a: CL:0000084 ! T cell
+is_a: PR:000050567
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex
intersection_of: RO:0002353 GO:0045058 ! output of T cell selection
@@ -35545,6 +35410,7 @@ id: CL:0002425
name: early T lineage precursor
comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative.
is_a: CL:0000827 ! pro-T cell
+is_a: PR:000050567
intersection_of: CL:0000827 ! pro-T cell
intersection_of: CL:4030046 PR:000001380 ! lacks_plasma_membrane_part interleukin-2 receptor subunit alpha
intersection_of: RO:0002104 PR:000001307 ! has plasma membrane part CD44 molecule
@@ -35702,6 +35568,7 @@ id: CL:0002438
name: NK1.1-positive natural killer cell, mouse
comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice.
is_a: CL:0000824 ! mature natural killer cell
+is_a: PR:000050567
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: RO:0002104 PR:000002977 ! has plasma membrane part killer cell lectin-like receptor subfamily B member 1C
intersection_of: RO:0002162 NCBITaxon:10090 ! in taxon Mus musculus
@@ -35883,6 +35750,7 @@ id: CL:0002476
name: bone marrow macrophage
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:0010004 ! mononuclear cell of bone marrow
+is_a: PR:000050567
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part receptor-type tyrosine-protein phosphatase C isoform CD45RABC
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
@@ -35899,6 +35767,7 @@ relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colo
id: CL:0002477
name: adipose macrophage
is_a: CL:0000864 ! tissue-resident macrophage
+is_a: PR:000050567
intersection_of: CL:0000864 ! tissue-resident macrophage
intersection_of: RO:0002104 PR:000001006 ! has plasma membrane part receptor-type tyrosine-protein phosphatase C
intersection_of: RO:0002104 PR:000001013 ! has plasma membrane part integrin alpha-X
@@ -36046,7 +35915,7 @@ relationship: BFO:0000050 UBERON:0002282 ! part of stria vascularis of cochlear
id: CL:0002494
name: cardiocyte
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ
relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ
@@ -36122,6 +35991,7 @@ relationship: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue
[Term]
id: CL:0002522
name: renal filtration cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000424 ! excretory cell
relationship: BFO:0000050 UBERON:0001008 ! part of renal system
@@ -36247,12 +36117,6 @@ intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: BFO:0000050 UBERON:0001638 ! part of vein
relationship: BFO:0000050 UBERON:0001638 ! part of vein
-[Term]
-id: CL:0002546
-name: embryonic blood vessel endothelial progenitor cell
-comment: See CL:0002619.
-is_a: CL:0000222 ! mesodermal cell
-
[Term]
id: CL:0002547
name: fibroblast of the aortic adventitia
@@ -36346,7 +36210,7 @@ relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery
[Term]
id: CL:0002559
name: hair follicle cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002073 ! part of hair follicle
relationship: BFO:0000050 UBERON:0002073 ! part of hair follicle
@@ -36775,7 +36639,7 @@ relationship: BFO:0000050 UBERON:0002097 ! part of skin of body
[Term]
id: CL:0002621
name: gingival epithelial cell
-is_a: CL:0002251 ! epithelial cell of alimentary canal
+is_a: CL:1001576 ! oral mucosa squamous cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001949 ! part of gingival epithelium
relationship: BFO:0000050 UBERON:0001949 ! part of gingival epithelium
@@ -36973,6 +36837,7 @@ intersection_of: RO:0002353 GO:0043379 ! output of memory T cell differentiation
id: CL:0002679
name: natural helper lymphocyte
is_a: CL:0000542 ! lymphocyte
+is_a: PR:000050567
intersection_of: CL:0000542 ! lymphocyte
intersection_of: CL:4030046 GO:0042105 ! lacks_plasma_membrane_part alpha-beta T cell receptor complex
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
@@ -37052,6 +36917,12 @@ is_a: CL:1000449 ! epithelial cell of nephron
id: CL:0005012
name: multi-ciliated epithelial cell
is_a: CL:0000067 ! ciliated epithelial cell
+is_a: CL:0000075 ! columnar/cuboidal epithelial cell
+intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
+intersection_of: BFO:0000051 GO:0031514 ! has part motile cilium
+intersection_of: RO:0000053 PATO:0010007 ! bearer of multiciliated
+relationship: BFO:0000051 GO:0031514 ! has part motile cilium
+relationship: RO:0000053 PATO:0010007 ! bearer of multiciliated
[Term]
id: CL:0005014
@@ -37115,6 +36986,7 @@ id: CL:0007000
name: preameloblast
comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008
is_a: CL:0000055 ! non-terminally differentiated cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ
relationship: RO:0002202 CL:0002077 ! develops from ecto-epithelial cell
relationship: RO:0002220 UBERON:0001763 ! adjacent to odontogenic papilla
@@ -37129,6 +37001,7 @@ is_a: CL:0000000 ! cell
id: CL:0007002
name: precementoblast
is_a: CL:0000055 ! non-terminally differentiated cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: BFO:0000050 UBERON:0005176 ! part of tooth enamel organ
[Term]
@@ -37243,6 +37116,7 @@ id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
is_a: CL:0000219 ! motile cell
+is_a: CL:0000255 ! eukaryotic cell
relationship: BFO:0000050 UBERON:0003104 ! part of mesenchyme
relationship: RO:0002215 GO:0016477 ! capable of cell migration
@@ -37362,6 +37236,13 @@ intersection_of: CL:0002319 ! neural cell
intersection_of: BFO:0000050 UBERON:0005388 ! part of photoreceptor array
relationship: BFO:0000050 UBERON:0005388 ! part of photoreceptor array
+[Term]
+id: CL:0009005
+name: salivary gland cell
+def: "Any cell in a salivary gland." []
+is_a: CL:0000255 ! eukaryotic cell
+relationship: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland
+
[Term]
id: CL:0009006
name: enteroendocrine cell of small intestine
@@ -37405,6 +37286,7 @@ relationship: BFO:0000050 UBERON:0001211 ! part of Peyer's patch
[Term]
id: CL:0009015
name: Peyer's patch follicular dendritic cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000442 ! follicular dendritic cell
intersection_of: CL:0000442 ! follicular dendritic cell
intersection_of: BFO:0000050 UBERON:0001211 ! part of Peyer's patch
@@ -37928,16 +37810,6 @@ intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0001310 ! part of umbilical artery
relationship: BFO:0000050 UBERON:0001310 ! part of umbilical artery
-[Term]
-id: CL:0010003
-name: epithelial cell of alveolus of lung
-def: "An epithelial cell that is part_of a alveolus of lung." []
-comment: May be merged with pneumocyte in future
-is_a: CL:0000066 ! epithelial cell
-intersection_of: CL:0000066 ! epithelial cell
-intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung
-relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung
-
[Term]
id: CL:0010004
name: mononuclear cell of bone marrow
@@ -38148,6 +38020,7 @@ name: CD25+ mast cell
def: "A mast cell that is CD25+." []
comment: Mast cells do not normally express CD25, but neoplastic mast cells may be CD25-positive.
is_a: CL:0001063 ! neoplastic cell
+is_a: PR:000050567
intersection_of: CL:0001063 ! neoplastic cell
intersection_of: RO:0001000 CL:0000097 ! derives from mast cell
intersection_of: RO:0002104 PR:000001380 ! has plasma membrane part interleukin-2 receptor subunit alpha
@@ -38165,6 +38038,7 @@ relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune r
[Term]
id: CL:0011026
name: progenitor cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: RO:0002202 CL:0000034 ! develops from stem cell
@@ -38321,6 +38195,7 @@ is_a: GO:0000792 ! heterochromatin
id: CL:0019001
name: tracheobronchial serous cell
def: "Any serous secreting cell that is part of the tracheobronchial epithelium." []
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000313 ! serous secreting cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree
@@ -38512,15 +38387,17 @@ relationship: RO:0002215 GO:0070483 ! capable of detection of hypoxia
[Term]
id: CL:1000271
name: lung ciliated cell
+is_a: CL:0000067 ! ciliated epithelial cell
+is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:4030034 ! respiratory ciliated cell
-intersection_of: CL:0000064 ! ciliated cell
-intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
-relationship: BFO:0000050 UBERON:0002048 ! part of lung
+intersection_of: CL:0000067 ! ciliated epithelial cell
+intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium
[Term]
id: CL:1000272
name: lung secretory cell
is_a: CL:0000151 ! secretory cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: BFO:0000050 UBERON:0002048 ! part of lung
relationship: BFO:0000050 UBERON:0002048 ! part of lung
@@ -38878,7 +38755,7 @@ intersection_of: BFO:0000050 UBERON:0001902 ! part of epithelium of small intest
[Term]
id: CL:1000347
-name: enterocyte of colon
+name: colonocyte
is_a: CL:0002071 ! enterocyte of epithelium of large intestine
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0002071 ! enterocyte of epithelium of large intestine
@@ -39259,6 +39136,7 @@ relationship: BFO:0000050 UBERON:0001230 ! part of glomerular capsule
[Term]
id: CL:1000452
name: parietal epithelial cell
+is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:1000450 ! epithelial cell of glomerular capsule
intersection_of: CL:0000066 ! epithelial cell
intersection_of: BFO:0000050 UBERON:0005750 ! part of glomerular parietal epithelium
@@ -39455,7 +39333,7 @@ relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine
id: CL:1000497
name: kidney cell
def: "A cell that is part of a kidney." []
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0002113 ! part of kidney
relationship: BFO:0000050 UBERON:0002113 ! part of kidney
@@ -39555,7 +39433,7 @@ relationship: BFO:0000050 UBERON:0005167 ! part of papillary duct
[Term]
id: CL:1000600
name: lower urinary tract cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001556 ! part of lower urinary tract
relationship: BFO:0000050 UBERON:0001556 ! part of lower urinary tract
@@ -39563,7 +39441,7 @@ relationship: BFO:0000050 UBERON:0001556 ! part of lower urinary tract
[Term]
id: CL:1000601
name: ureteral cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000056 ! part of ureter
relationship: BFO:0000050 UBERON:0000056 ! part of ureter
@@ -40549,6 +40427,7 @@ name: salivary gland glandular cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
+is_a: CL:0009005 ! salivary gland cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: BFO:0000050 UBERON:0001044 ! part of saliva-secreting gland
relationship: BFO:0000050 UBERON:0004809 ! part of salivary gland epithelium
@@ -40807,7 +40686,7 @@ relationship: BFO:0000050 UBERON:0000018 ! part of compound eye
[Term]
id: CL:2000020
name: inner cell mass cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0000087 ! part of inner cell mass
relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass
@@ -40815,7 +40694,7 @@ relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass
[Term]
id: CL:2000021
name: sebaceous gland cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0001821 ! part of sebaceous gland
relationship: BFO:0000050 UBERON:0001821 ! part of sebaceous gland
@@ -41394,7 +41273,7 @@ relationship: BFO:0000050 UBERON:8300000 ! part of skin of scalp
[Term]
id: CL:4023015
name: sncg GABAergic cortical interneuron
-is_a: CL:4023064 ! caudal ganglionic eminence derived interneuron
+is_a: CL:4023064 ! caudal ganglionic eminence derived cortical interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
@@ -41404,8 +41283,8 @@ relationship: RO:0002292 PR:000015325 ! expresses gamma-synuclein
[Term]
id: CL:4023017
name: sst GABAergic cortical interneuron
-is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
-intersection_of: CL:0000099 ! interneuron
+is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic cortical interneuron
+intersection_of: CL:4023069 ! medial ganglionic eminence derived GABAergic cortical interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002292 PR:000015665 ! expresses somatostatin
@@ -41414,8 +41293,8 @@ relationship: RO:0002292 PR:000015665 ! expresses somatostatin
[Term]
id: CL:4023018
name: pvalb GABAergic cortical interneuron
-is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
-intersection_of: CL:0000099 ! interneuron
+is_a: CL:4023069 ! medial ganglionic eminence derived GABAergic cortical interneuron
+intersection_of: CL:4023069 ! medial ganglionic eminence derived GABAergic cortical interneuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secretion, neurotransmission
intersection_of: RO:0002292 PR:000013502 ! expresses parvalbumin alpha
@@ -41468,7 +41347,7 @@ relationship: RO:0002202 UBERON:0004024 ! develops from medial ganglionic eminen
[Term]
id: CL:4023064
-name: caudal ganglionic eminence derived interneuron
+name: caudal ganglionic eminence derived cortical interneuron
is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002202 UBERON:0004026 ! develops from caudal ganglionic eminence
@@ -41690,7 +41569,6 @@ intersection_of: RO:0002215 GO:0061534 ! capable of gamma-aminobutyric acid secr
[Term]
id: CL:4030028
name: glycinergic amacrine cell
-def: "An amacrine cell that uses glycine as a neurotransmitter." [] {def="https://doi.org/10.1016/j.cell.2020.08.013"}
is_a: CL:0000561 ! amacrine cell
is_a: CL:1001509 ! glycinergic neuron
intersection_of: CL:0000561 ! amacrine cell
@@ -41707,7 +41585,7 @@ intersection_of: BFO:0000050 UBERON:0000178 ! part of blood
[Term]
id: CL:4030031
name: interstitial cell
-is_a: CL:0000000 ! cell
+is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: BFO:0000050 UBERON:0005169 ! part of interstitial tissue
relationship: BFO:0000050 UBERON:0005169 ! part of interstitial tissue
@@ -41761,6 +41639,7 @@ relationship: BFO:0000051 GO:0097729 ! has part 9+2 motile cilium
id: CL:4030058
name: TCR-positive macrophage
is_a: CL:0000235 ! macrophage
+is_a: PR:000050567
intersection_of: CL:0000235 ! macrophage
intersection_of: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex
relationship: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex
@@ -42012,9 +41891,10 @@ relationship: BFO:0000050 UBERON:0000995 ! part of uterus
[Term]
id: CL:4033066
name: pre-granulosa cell
+is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000630 ! supporting cell
relationship: BFO:0000050 UBERON:0000992 ! part of ovary
-relationship: RO:0002210 CL:0000501 ! directly develops into granulosa cell
+relationship: RO:0002210 CL:4033083 ! directly develops into squamous granulosa cell
[Term]
id: CL:4033068
@@ -42161,6 +42041,21 @@ intersection_of: RO:0000086 PATO:0002354 ! has quality active
relationship: RO:0000056 GO:0022402 ! participates in cell cycle process
relationship: RO:0000086 PATO:0002354 ! has quality active
+[Term]
+id: CL:4033083
+name: squamous granulosa cell
+is_a: CL:0000501 ! granulosa cell
+relationship: BFO:0000050 UBERON:0003981 ! part of primordial ovarian follicle
+relationship: RO:0002207 CL:4033066 ! directly develops from pre-granulosa cell
+relationship: RO:0002210 CL:4033084 ! directly develops into cuboidal granulosa cell
+
+[Term]
+id: CL:4033084
+name: cuboidal granulosa cell
+is_a: CL:0000501 ! granulosa cell
+is_a: UBERON:0004120 ! mesoderm-derived structure
+relationship: RO:0002207 CL:4033083 ! directly develops from squamous granulosa cell
+
[Term]
id: CL:4040002
name: enteroglial cell
@@ -42228,6 +42123,24 @@ intersection_of: RO:0000086 PATO:0002354 ! has quality active
relationship: RO:0000056 GO:0022402 ! participates in cell cycle process
relationship: RO:0000086 PATO:0002354 ! has quality active
+[Term]
+id: CL:4052002
+name: syncytial cell
+is_a: CL:0000228 ! multinucleate cell
+intersection_of: CL:0000000 ! cell
+intersection_of: RO:0000053 PATO:0001908 ! bearer of multinucleate
+intersection_of: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion
+relationship: RO:0002353 GO:0000768 ! output of syncytium formation by plasma membrane fusion
+
+[Term]
+id: CL:4052003
+name: intestinal villus capillary endothelial cell
+is_a: CL:0000666 ! fenestrated endothelial cell
+is_a: CL:0002144 ! capillary endothelial cell
+intersection_of: CL:0002144 ! capillary endothelial cell
+intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus
+relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus
+
[Term]
id: GO:0000001
name: mitochondrion inheritance
@@ -42312,7 +42225,6 @@ id: GO:0000050
name: urea cycle
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043604 ! amide biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:16199 ! has primary output urea
relationship: RO:0004008 CHEBI:16199 ! has primary output urea
@@ -42388,7 +42300,6 @@ id: GO:0000096
name: sulfur amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26834 ! has primary input or output sulfur-containing amino acid
relationship: RO:0004007 CHEBI:26834 ! has primary input or output sulfur-containing amino acid
@@ -42399,7 +42310,6 @@ name: sulfur amino acid biosynthetic process
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26834 ! has primary output sulfur-containing amino acid
relationship: RO:0004008 CHEBI:26834 ! has primary output sulfur-containing amino acid
@@ -42410,7 +42320,6 @@ name: sulfur amino acid catabolic process
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:26834 ! has primary input sulfur-containing amino acid
relationship: RO:0004009 CHEBI:26834 ! has primary input sulfur-containing amino acid
@@ -42488,7 +42397,6 @@ is_a: GO:0005515 ! protein binding
[Term]
id: GO:0000162
name: tryptophan biosynthetic process
-is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process
is_a: GO:1901607 ! alpha-amino acid biosynthetic process
@@ -42653,10 +42561,10 @@ relationship: BFO:0000050 GO:0043226 ! part of organelle
[Term]
id: GO:0000316
-name: sulfite transport
-is_a: GO:0015698 ! inorganic anion transport
+name: sulfite transmembrane transport
is_a: GO:0072348 ! sulfur compound transport
-intersection_of: GO:0006810 ! transport
+is_a: GO:0098661 ! inorganic anion transmembrane transport
+intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:17359 ! has primary input sulfite
relationship: RO:0004009 CHEBI:17359 ! has primary input sulfite
@@ -42667,7 +42575,7 @@ is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:17359 ! has primary input sulfite
-relationship: BFO:0000050 GO:0000316 ! part of sulfite transport
+relationship: BFO:0000050 GO:0000316 ! part of sulfite transmembrane transport
relationship: RO:0004009 CHEBI:17359 ! has primary input sulfite
[Term]
@@ -42688,8 +42596,6 @@ relationship: RO:0002007 GO:0005776 ! bounding layer of autophagosome
id: GO:0000422
name: autophagy of mitochondrion
is_a: GO:0006914 ! autophagy
-is_a: GO:0007005 ! mitochondrion organization
-is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0006914 ! autophagy
intersection_of: RO:0004009 GO:0005739 ! has primary input mitochondrion
relationship: RO:0004009 GO:0005739 ! has primary input mitochondrion
@@ -42805,7 +42711,7 @@ relationship: RO:0002008 SO:0000624 ! coincident with telomere
id: GO:0000785
name: chromatin
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
-is_a: GO:0032993 ! protein-DNA complex
+is_a: GO:0110165 ! cellular anatomical entity
relationship: BFO:0000050 GO:0005694 ! part of chromosome
[Term]
@@ -44604,7 +44510,6 @@ relationship: RO:0002212 GO:0006468 ! negatively regulates protein phosphorylati
[Term]
id: GO:0001934
name: positive regulation of protein phosphorylation
-comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
@@ -46968,13 +46873,13 @@ intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response
[Term]
id: GO:0002538
-name: arachidonic acid metabolite production involved in inflammatory response
+name: arachidonate metabolite production involved in inflammatory response
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
[Term]
id: GO:0002539
name: prostaglandin production involved in inflammatory response
-is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response
+is_a: GO:0002538 ! arachidonate metabolite production involved in inflammatory response
[Term]
id: GO:0002548
@@ -49149,7 +49054,6 @@ id: GO:0002936
name: bradykinin biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:132988 ! has primary output bradykinin(2+)
relationship: RO:0004008 CHEBI:132988 ! has primary output bradykinin(2+)
@@ -50861,7 +50765,7 @@ relationship: RO:0004009 CHEBI:16991 ! has primary input deoxyribonucleic acid
[Term]
id: GO:0003682
name: chromatin binding
-is_a: GO:0044877 ! protein-containing complex binding
+is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0000785 ! has primary input chromatin
relationship: RO:0004009 GO:0000785 ! has primary input chromatin
@@ -50937,15 +50841,6 @@ id: GO:0003824
name: catalytic activity
is_a: GO:0003674 ! molecular_function
-[Term]
-id: GO:0003867
-name: 4-aminobutyrate transaminase activity
-is_a: GO:0008483 ! transaminase activity
-relationship: RO:0000057 CHEBI:16810 ! has participant 2-oxoglutarate(2-)
-relationship: RO:0000057 CHEBI:29985 ! has participant L-glutamate(1-)
-relationship: RO:0000057 CHEBI:57706 ! has participant 4-oxobutanoate
-relationship: RO:0000057 CHEBI:59888 ! has participant gamma-aminobutyric acid zwitterion
-
[Term]
id: GO:0003870
name: 5-aminolevulinate synthase activity
@@ -50957,16 +50852,6 @@ relationship: RO:0000057 CHEBI:57287 ! has participant coenzyme A(4-)
relationship: RO:0000057 CHEBI:57292 ! has participant succinyl-CoA(5-)
relationship: RO:0000057 CHEBI:57305 ! has participant glycine zwitterion
-[Term]
-id: GO:0003984
-name: acetolactate synthase activity
-comment: Note that this function was formerly EC:4.1.3.18.
-is_a: GO:0016744 ! transketolase or transaldolase activity
-relationship: RO:0000057 CHEBI:15361 ! has participant pyruvate
-relationship: RO:0000057 CHEBI:15378 ! has participant hydron
-relationship: RO:0000057 CHEBI:16526 ! has participant carbon dioxide
-relationship: RO:0000057 CHEBI:58476 ! has participant (2S)-2-hydroxy-2-methyl-3-oxobutanoate
-
[Term]
id: GO:0003990
name: acetylcholinesterase activity
@@ -50990,11 +50875,6 @@ id: GO:0004035
name: alkaline phosphatase activity
is_a: GO:0016791 ! phosphatase activity
-[Term]
-id: GO:0004084
-name: branched-chain-amino-acid transaminase activity
-is_a: GO:0008483 ! transaminase activity
-
[Term]
id: GO:0004095
name: carnitine O-palmitoyltransferase activity
@@ -51043,14 +50923,6 @@ relationship: RO:0000057 CHEBI:456216 ! has participant ADP(3-)
relationship: RO:0000057 CHEBI:57947 ! has participant creatine zwitterion
relationship: RO:0000057 CHEBI:58092 ! has participant N-phosphocreatinate(2-)
-[Term]
-id: GO:0004160
-name: dihydroxy-acid dehydratase activity
-is_a: GO:0016836 ! hydro-lyase activity
-relationship: RO:0000057 CHEBI:11424 ! has participant 2,3-dihydroxy-3-methylbutanoate
-relationship: RO:0000057 CHEBI:11851 ! has participant 3-methyl-2-oxobutanoate
-relationship: RO:0000057 CHEBI:15377 ! has participant water
-
[Term]
id: GO:0004175
name: endopeptidase activity
@@ -51102,7 +50974,7 @@ is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than
[Term]
id: GO:0004365
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
-is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
+is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
relationship: RO:0000057 CHEBI:15378 ! has participant hydron
relationship: RO:0000057 CHEBI:43474 ! has participant hydrogenphosphate
relationship: RO:0000057 CHEBI:57540 ! has participant NAD(1-)
@@ -51124,7 +50996,6 @@ relationship: RO:0000057 CHEBI:456216 ! has participant ADP(3-)
[Term]
id: GO:0004418
name: hydroxymethylbilane synthase activity
-comment: Note that this function was formerly EC:4.3.1.8.
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
relationship: RO:0000057 CHEBI:15377 ! has participant water
relationship: RO:0000057 CHEBI:28938 ! has participant ammonium
@@ -51141,20 +51012,10 @@ relationship: RO:0000057 CHEBI:16240 ! has participant hydrogen peroxide
relationship: RO:0000057 CHEBI:16382 ! has participant iodide
relationship: RO:0000057 CHEBI:17606 ! has participant
-[Term]
-id: GO:0004455
-name: ketol-acid reductoisomerase activity
-is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
-relationship: RO:0000057 CHEBI:15378 ! has participant hydron
-relationship: RO:0000057 CHEBI:49072 ! has participant (R)-2,3-dihydroxy-3-methylbutanoate
-relationship: RO:0000057 CHEBI:57783 ! has participant NADPH(4-)
-relationship: RO:0000057 CHEBI:58349 ! has participant NADP(3-)
-relationship: RO:0000057 CHEBI:58476 ! has participant (2S)-2-hydroxy-2-methyl-3-oxobutanoate
-
[Term]
id: GO:0004465
name: lipoprotein lipase activity
-is_a: GO:0004806 ! triglyceride lipase activity
+is_a: GO:0004806 ! triacylglycerol lipase activity
[Term]
id: GO:0004497
@@ -51342,15 +51203,21 @@ relationship: BFO:0000050 GO:0006096 ! part of glycolytic process
[Term]
id: GO:0004806
-name: triglyceride lipase activity
+name: triacylglycerol lipase activity
is_a: GO:0016298 ! lipase activity
-is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: RO:0000057 CHEBI:15377 ! has participant water
relationship: RO:0000057 CHEBI:15378 ! has participant hydron
relationship: RO:0000057 CHEBI:17855 ! has participant triglyceride
relationship: RO:0000057 CHEBI:18035 ! has participant diglyceride
relationship: RO:0000057 CHEBI:28868 ! has participant fatty acid anion
+[Term]
+id: GO:0004838
+name: L-tyrosine-2-oxoglutarate transaminase activity
+is_a: GO:0008793 ! aromatic-amino-acid transaminase activity
+relationship: RO:0000057 CHEBI:36242 ! has participant 3-(4-hydroxyphenyl)pyruvate
+relationship: RO:0000057 CHEBI:58315 ! has participant L-tyrosine zwitterion
+
[Term]
id: GO:0004854
name: xanthine dehydrogenase activity
@@ -52075,18 +51942,6 @@ intersection_of: RO:0004009 CHEBI:58315 ! has primary input L-tyrosine zwitterio
relationship: BFO:0000050 GO:0015828 ! part of tyrosine transport
relationship: RO:0004009 CHEBI:58315 ! has primary input L-tyrosine zwitterion
-[Term]
-id: GO:0005304
-name: L-valine transmembrane transporter activity
-is_a: GO:0015101 ! organic cation transmembrane transporter activity
-is_a: GO:0015175 ! neutral L-amino acid transmembrane transporter activity
-is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
-is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity
-intersection_of: GO:0022857 ! transmembrane transporter activity
-intersection_of: RO:0004009 CHEBI:57762 ! has primary input L-valine zwitterion
-relationship: BFO:0000050 GO:1903785 ! part of L-valine transmembrane transport
-relationship: RO:0004009 CHEBI:57762 ! has primary input L-valine zwitterion
-
[Term]
id: GO:0005308
name: creatine transmembrane transporter activity
@@ -52242,15 +52097,6 @@ relationship: BFO:0000050 GO:0015757 ! part of galactose transmembrane transport
relationship: RO:0000057 CHEBI:4139 ! has participant D-galactopyranose
relationship: RO:0004009 CHEBI:28260 ! has primary input galactose
-[Term]
-id: GO:0005355
-name: glucose transmembrane transporter activity
-is_a: GO:0055056 ! D-glucose transmembrane transporter activity
-intersection_of: GO:0022857 ! transmembrane transporter activity
-intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose
-relationship: BFO:0000050 GO:1904659 ! part of glucose transmembrane transport
-relationship: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose
-
[Term]
id: GO:0005368
name: taurine transmembrane transporter activity
@@ -52311,7 +52157,6 @@ intersection_of: RO:0004009 CHEBI:15361 ! has primary input pyruvate
[Term]
id: GO:0005488
name: binding
-comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
is_a: GO:0003674 ! molecular_function
[Term]
@@ -52662,22 +52507,6 @@ name: mitochondrial inner membrane
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031966 ! mitochondrial membrane
-[Term]
-id: GO:0005746
-name: mitochondrial respirasome
-is_a: GO:0070469 ! respirasome
-is_a: GO:0098800 ! inner mitochondrial membrane protein complex
-intersection_of: GO:0070469 ! respirasome
-intersection_of: BFO:0000050 GO:0005743 ! part of mitochondrial inner membrane
-
-[Term]
-id: GO:0005753
-name: mitochondrial proton-transporting ATP synthase complex
-is_a: GO:0045259 ! proton-transporting ATP synthase complex
-is_a: GO:0098800 ! inner mitochondrial membrane protein complex
-intersection_of: GO:0045259 ! proton-transporting ATP synthase complex
-intersection_of: BFO:0000050 GO:0005739 ! part of mitochondrion
-
[Term]
id: GO:0005759
name: mitochondrial matrix
@@ -53042,16 +52871,6 @@ is_a: GO:0032156 ! septin cytoskeleton
relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton
relationship: BFO:0000050 GO:0005938 ! part of cell cortex
-[Term]
-id: GO:0005948
-name: acetolactate synthase complex
-comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
-is_a: GO:1990234 ! transferase complex
-intersection_of: GO:0032991 ! protein-containing complex
-intersection_of: RO:0002215 GO:0003984 ! capable of acetolactate synthase activity
-relationship: BFO:0000050 GO:0005737 ! part of cytoplasm
-relationship: RO:0002215 GO:0003984 ! capable of acetolactate synthase activity
-
[Term]
id: GO:0005975
name: carbohydrate metabolic process
@@ -53237,7 +53056,6 @@ id: GO:0006022
name: aminoglycan metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan
relationship: RO:0004007 CHEBI:22506 ! has primary input or output aminoglycan
@@ -53248,7 +53066,6 @@ name: aminoglycan biosynthetic process
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:22506 ! has primary output aminoglycan
relationship: RO:0004008 CHEBI:22506 ! has primary output aminoglycan
@@ -53268,7 +53085,6 @@ name: aminoglycan catabolic process
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:22506 ! has primary input aminoglycan
relationship: RO:0004009 CHEBI:22506 ! has primary input aminoglycan
@@ -53484,7 +53300,7 @@ intersection_of: GO:0016052 ! carbohydrate catabolic process
intersection_of: BFO:0000051 GO:0004618 ! has part phosphoglycerate kinase activity
intersection_of: BFO:0000051 GO:0004619 ! has part phosphoglycerate mutase activity
intersection_of: BFO:0000051 GO:0004634 ! has part phosphopyruvate hydratase activity
-intersection_of: BFO:0000051 GO:0043891 ! has part glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
+intersection_of: BFO:0000051 GO:0043891 ! has part glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
intersection_of: RO:0002230 GO:0004743 ! ends with pyruvate kinase activity
intersection_of: RO:0004008 CHEBI:15361 ! has primary output pyruvate
intersection_of: RO:0004008 CHEBI:30616 ! has primary output ATP(4-)
@@ -53494,7 +53310,7 @@ intersection_of: RO:0004009 CHEBI:456216 ! has primary input ADP(3-)
relationship: BFO:0000051 GO:0004618 ! has part phosphoglycerate kinase activity
relationship: BFO:0000051 GO:0004619 ! has part phosphoglycerate mutase activity
relationship: BFO:0000051 GO:0004634 ! has part phosphopyruvate hydratase activity
-relationship: BFO:0000051 GO:0043891 ! has part glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
+relationship: BFO:0000051 GO:0043891 ! has part glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
relationship: RO:0002230 GO:0004743 ! ends with pyruvate kinase activity
relationship: RO:0004008 CHEBI:15361 ! has primary output pyruvate
relationship: RO:0004008 CHEBI:30616 ! has primary output ATP(4-)
@@ -53913,7 +53729,7 @@ is_a: GO:0006259 ! DNA metabolic process
[Term]
id: GO:0006325
name: chromatin organization
-is_a: GO:0071824 ! protein-DNA complex organization
+is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin
relationship: RO:0002592 GO:0000785 ! results in organization of chromatin
@@ -54048,7 +53864,6 @@ id: GO:0006412
name: translation
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: BFO:0000050 GO:0010467 ! part of gene expression
intersection_of: RO:0004008 CHEBI:36080 ! has primary output protein
@@ -54228,15 +54043,6 @@ intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:32696 ! has primary input or output argininium(1+)
relationship: RO:0004007 CHEBI:32696 ! has primary input or output argininium(1+)
-[Term]
-id: GO:0006526
-name: arginine biosynthetic process
-is_a: GO:0006525 ! arginine metabolic process
-is_a: GO:0009084 ! glutamine family amino acid biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:32696 ! has primary output argininium(1+)
-relationship: RO:0004008 CHEBI:32696 ! has primary output argininium(1+)
-
[Term]
id: GO:0006527
name: arginine catabolic process
@@ -54273,35 +54079,6 @@ intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:32660 ! has primary input asparaginate
relationship: RO:0004009 CHEBI:32660 ! has primary input asparaginate
-[Term]
-id: GO:0006531
-name: aspartate metabolic process
-is_a: GO:0009066 ! aspartate family amino acid metabolic process
-is_a: GO:0043648 ! dicarboxylic acid metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:35391 ! has primary input or output aspartate(1-)
-relationship: RO:0004007 CHEBI:35391 ! has primary input or output aspartate(1-)
-
-[Term]
-id: GO:0006532
-name: aspartate biosynthetic process
-is_a: GO:0006531 ! aspartate metabolic process
-is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
-is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:35391 ! has primary output aspartate(1-)
-relationship: RO:0004008 CHEBI:35391 ! has primary output aspartate(1-)
-
-[Term]
-id: GO:0006533
-name: aspartate catabolic process
-is_a: GO:0006531 ! aspartate metabolic process
-is_a: GO:0009068 ! aspartate family amino acid catabolic process
-is_a: GO:0043649 ! dicarboxylic acid catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-relationship: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-
[Term]
id: GO:0006534
name: cysteine metabolic process
@@ -54350,27 +54127,17 @@ intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
relationship: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-[Term]
-id: GO:0006539
-name: glutamate catabolic process via 2-oxoglutarate
-is_a: GO:0006103 ! 2-oxoglutarate metabolic process
-is_a: GO:0006538 ! glutamate catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0002505 CHEBI:16810 ! has intermediate 2-oxoglutarate(2-)
-intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-relationship: RO:0002505 CHEBI:16810 ! has intermediate 2-oxoglutarate(2-)
-
[Term]
id: GO:0006540
-name: glutamate decarboxylation to succinate
+name: gamma-aminobutyrate shunt
comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004008 CHEBI:30031 ! has primary output succinate(2-)
intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-relationship: BFO:0000051 GO:0003867 ! has part 4-aminobutyrate transaminase activity
relationship: BFO:0000051 GO:0004351 ! has part glutamate decarboxylase activity
+relationship: BFO:0000051 GO:0034386 ! has part 4-aminobutyrate:2-oxoglutarate transaminase activity
relationship: RO:0004008 CHEBI:30031 ! has primary output succinate(2-)
[Term]
@@ -54614,15 +54381,15 @@ id: GO:0006568
name: tryptophan metabolic process
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
-is_a: GO:1901605 ! alpha-amino acid metabolic process
+is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:64554 ! has primary input or output tryptophan zwitterion
-relationship: RO:0004007 CHEBI:64554 ! has primary input or output tryptophan zwitterion
+intersection_of: RO:0004007 CHEBI:57912 ! has primary input or output L-tryptophan zwitterion
+relationship: RO:0004007 CHEBI:57912 ! has primary input or output L-tryptophan zwitterion
[Term]
id: GO:0006569
name: tryptophan catabolic process
-is_a: GO:0006568 ! tryptophan metabolic process
+is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
@@ -54682,7 +54449,6 @@ relationship: RO:0004009 CHEBI:27266 ! has primary input valine
id: GO:0006575
name: cellular modified amino acid metabolic process
is_a: GO:0044237 ! cellular metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:83821 ! has primary input or output amino acid derivative
relationship: RO:0004007 CHEBI:83821 ! has primary input or output amino acid derivative
@@ -54788,8 +54554,10 @@ relationship: RO:0004007 CHEBI:38631 ! has primary input or output aminoalkylind
[Term]
id: GO:0006587
name: serotonin biosynthetic process from tryptophan
-is_a: GO:0006568 ! tryptophan metabolic process
+is_a: GO:0006586 ! indolalkylamine metabolic process
+is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0042427 ! serotonin biosynthetic process
+is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:350546 ! has primary output serotonin(1+)
intersection_of: RO:0004009 CHEBI:64554 ! has primary input tryptophan zwitterion
@@ -55028,11 +54796,10 @@ relationship: RO:0004008 CHEBI:2580 ! has primary output unsaturated fatty acid
[Term]
id: GO:0006637
name: acyl-CoA metabolic process
-is_a: GO:0009150 ! purine ribonucleotide metabolic process
-is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
-is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
+is_a: GO:0006753 ! nucleoside phosphate metabolic process
is_a: GO:0035383 ! thioester metabolic process
is_a: GO:0043603 ! amide metabolic process
+is_a: GO:0072521 ! purine-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:58342 ! has primary input or output acyl-CoA(4-)
relationship: RO:0004007 CHEBI:58342 ! has primary input or output acyl-CoA(4-)
@@ -55123,7 +54890,6 @@ id: GO:0006656
name: phosphatidylcholine biosynthetic process
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:64482 ! has primary output phosphatidylcholine
relationship: RO:0004008 CHEBI:64482 ! has primary output phosphatidylcholine
@@ -55158,7 +54924,6 @@ relationship: RO:0004007 CHEBI:33563 ! has primary input or output glycolipid
id: GO:0006665
name: sphingolipid metabolic process
is_a: GO:0006643 ! membrane lipid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26739 ! has primary input or output sphingolipid
relationship: RO:0004007 CHEBI:26739 ! has primary input or output sphingolipid
@@ -56267,7 +56032,6 @@ relationship: RO:0002297 CL:0000228 ! results in formation of multinucleate cell
[Term]
id: GO:0006950
name: response to stress
-comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_a: GO:0050896 ! response to stimulus
[Term]
@@ -57974,6 +57738,8 @@ intersection_of: GO:0046907 ! intracellular transport
intersection_of: BFO:0000066 GO:0043005 ! occurs in neuron projection
intersection_of: RO:0002341 GO:0005874 ! results in transport along microtubule
relationship: BFO:0000066 GO:0043005 ! occurs in neuron projection
+relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa
+relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! in taxon Metazoa
[Term]
id: GO:0008089
@@ -58236,15 +58002,6 @@ is_a: GO:0015291 ! secondary active transmembrane transporter activity
intersection_of: GO:0015291 ! secondary active transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:16189 ! has primary input sulfate
-[Term]
-id: GO:0008272
-name: sulfate transport
-is_a: GO:0015698 ! inorganic anion transport
-is_a: GO:0072348 ! sulfur compound transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0004009 CHEBI:16189 ! has primary input sulfate
-relationship: RO:0004009 CHEBI:16189 ! has primary input sulfate
-
[Term]
id: GO:0008277
name: regulation of G protein-coupled receptor signaling pathway
@@ -58592,8 +58349,9 @@ relationship: RO:0004009 CHEBI:28938 ! has primary input ammonium
id: GO:0008521
name: acetyl-CoA transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
+is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
+is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
-is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:57288 ! has primary input acetyl-CoA(4-)
@@ -58728,6 +58486,15 @@ id: GO:0008757
name: S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0008168 ! methyltransferase activity
+[Term]
+id: GO:0008793
+name: aromatic-amino-acid transaminase activity
+is_a: GO:0008483 ! transaminase activity
+relationship: RO:0000057 CHEBI:16810 ! has participant 2-oxoglutarate(2-)
+relationship: RO:0000057 CHEBI:29985 ! has participant L-glutamate(1-)
+relationship: RO:0000057 CHEBI:73309 ! has participant
+relationship: RO:0000057 CHEBI:84824 ! has participant
+
[Term]
id: GO:0009008
name: DNA-methyltransferase activity
@@ -58739,7 +58506,6 @@ id: GO:0009050
name: glycopeptide catabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:24396 ! has primary input glycopeptide
relationship: RO:0004009 CHEBI:24396 ! has primary input glycopeptide
@@ -58884,7 +58650,6 @@ id: GO:0009072
name: aromatic amino acid metabolic process
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33856 ! has primary input or output aromatic amino acid
relationship: RO:0004007 CHEBI:33856 ! has primary input or output aromatic amino acid
@@ -58894,7 +58659,6 @@ id: GO:0009073
name: aromatic amino acid family biosynthetic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33856 ! has primary output aromatic amino acid
relationship: RO:0004008 CHEBI:33856 ! has primary output aromatic amino acid
@@ -58904,7 +58668,6 @@ id: GO:0009074
name: aromatic amino acid family catabolic process
is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33856 ! has primary input aromatic amino acid
relationship: RO:0004009 CHEBI:33856 ! has primary input aromatic amino acid
@@ -58943,7 +58706,6 @@ id: GO:0009081
name: branched-chain amino acid metabolic process
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:22918 ! has primary input or output branched-chain amino acid
relationship: RO:0004007 CHEBI:22918 ! has primary input or output branched-chain amino acid
@@ -58953,7 +58715,6 @@ id: GO:0009082
name: branched-chain amino acid biosynthetic process
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:22918 ! has primary output branched-chain amino acid
relationship: RO:0004008 CHEBI:22918 ! has primary output branched-chain amino acid
@@ -58964,7 +58725,6 @@ name: branched-chain amino acid catabolic process
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0009081 ! branched-chain amino acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:22918 ! has primary input branched-chain amino acid
relationship: RO:0004009 CHEBI:22918 ! has primary input branched-chain amino acid
@@ -59066,20 +58826,6 @@ intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:57427 ! has primary output L-leucine zwitterion
relationship: RO:0004008 CHEBI:57427 ! has primary output L-leucine zwitterion
-[Term]
-id: GO:0009099
-name: valine biosynthetic process
-is_a: GO:0006573 ! valine metabolic process
-is_a: GO:0009082 ! branched-chain amino acid biosynthetic process
-is_a: GO:1901607 ! alpha-amino acid biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:27266 ! has primary output valine
-relationship: BFO:0000051 GO:0003984 ! has part acetolactate synthase activity
-relationship: BFO:0000051 GO:0004160 ! has part dihydroxy-acid dehydratase activity
-relationship: BFO:0000051 GO:0004455 ! has part ketol-acid reductoisomerase activity
-relationship: BFO:0000051 GO:0052655 ! has part L-valine transaminase activity
-relationship: RO:0004008 CHEBI:27266 ! has primary output valine
-
[Term]
id: GO:0009100
name: glycoprotein metabolic process
@@ -59095,7 +58841,6 @@ name: glycoprotein biosynthetic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:17089 ! has primary output glycoprotein
relationship: RO:0004008 CHEBI:17089 ! has primary output glycoprotein
@@ -59118,7 +58863,6 @@ is_a: GO:0044282 ! small molecule catabolic process
id: GO:0009112
name: nucleobase metabolic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase
relationship: RO:0004007 CHEBI:18282 ! has primary input or output nucleobase
@@ -59146,7 +58890,6 @@ relationship: RO:0004009 CHEBI:15318 ! has primary input xanthine
id: GO:0009116
name: nucleoside metabolic process
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901657 ! glycosyl compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:33838 ! has primary input or output nucleoside
@@ -59349,7 +59092,6 @@ id: GO:0009163
name: nucleoside biosynthetic process
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901659 ! glycosyl compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:33838 ! has primary output nucleoside
@@ -59360,7 +59102,6 @@ id: GO:0009164
name: nucleoside catabolic process
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901658 ! glycosyl compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:33838 ! has primary input nucleoside
@@ -59710,7 +59451,7 @@ is_a: GO:0035592 ! establishment of protein localization to extracellular region
[Term]
id: GO:0009308
name: amine metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:32952 ! has primary input or output amine
relationship: RO:0004007 CHEBI:32952 ! has primary input or output amine
@@ -59718,8 +59459,8 @@ relationship: RO:0004007 CHEBI:32952 ! has primary input or output amine
[Term]
id: GO:0009309
name: amine biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009308 ! amine metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:32952 ! has primary output amine
relationship: RO:0004008 CHEBI:32952 ! has primary output amine
@@ -59727,8 +59468,8 @@ relationship: RO:0004008 CHEBI:32952 ! has primary output amine
[Term]
id: GO:0009310
name: amine catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0009308 ! amine metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine
@@ -59929,34 +59670,6 @@ name: plastid stroma
is_a: GO:0110165 ! cellular anatomical entity
relationship: BFO:0000050 GO:0009536 ! part of plastid
-[Term]
-id: GO:0009533
-name: chloroplast stromal thylakoid
-is_a: GO:0009534 ! chloroplast thylakoid
-intersection_of: GO:0009534 ! chloroplast thylakoid
-intersection_of: BFO:0000050 GO:0009570 ! part of chloroplast stroma
-relationship: BFO:0000050 GO:0009570 ! part of chloroplast stroma
-relationship: RO:0002160 NCBITaxon:33090 ! only in taxon Viridiplantae
-relationship: RO:0002162 NCBITaxon:33090 {all_only="true"} ! in taxon Viridiplantae
-
-[Term]
-id: GO:0009534
-name: chloroplast thylakoid
-is_a: GO:0031976 ! plastid thylakoid
-intersection_of: GO:0009579 ! thylakoid
-intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
-relationship: BFO:0000050 GO:0009507 ! part of chloroplast
-
-[Term]
-id: GO:0009535
-name: chloroplast thylakoid membrane
-is_a: GO:0031968 ! organelle outer membrane
-is_a: GO:0055035 ! plastid thylakoid membrane
-intersection_of: GO:0042651 ! thylakoid membrane
-intersection_of: RO:0002007 GO:0009534 ! bounding layer of chloroplast thylakoid
-relationship: BFO:0000050 GO:0009534 ! part of chloroplast thylakoid
-relationship: RO:0002007 GO:0009534 ! bounding layer of chloroplast thylakoid
-
[Term]
id: GO:0009536
name: plastid
@@ -59988,12 +59701,6 @@ name: chloroplast stroma
is_a: GO:0009532 ! plastid stroma
relationship: BFO:0000050 GO:0009507 ! part of chloroplast
-[Term]
-id: GO:0009579
-name: thylakoid
-comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.
-is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
-
[Term]
id: GO:0009581
name: detection of external stimulus
@@ -60391,7 +60098,7 @@ relationship: RO:0004008 CHEBI:26775 ! has primary output stilbene
[Term]
id: GO:0009820
name: alkaloid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:22315 ! has primary input or output alkaloid
relationship: RO:0004007 CHEBI:22315 ! has primary input or output alkaloid
@@ -60401,7 +60108,6 @@ id: GO:0009821
name: alkaloid biosynthetic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:22315 ! has primary output alkaloid
relationship: RO:0004008 CHEBI:22315 ! has primary output alkaloid
@@ -60409,8 +60115,8 @@ relationship: RO:0004008 CHEBI:22315 ! has primary output alkaloid
[Term]
id: GO:0009822
name: alkaloid catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0009820 ! alkaloid metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:22315 ! has primary input alkaloid
relationship: RO:0004009 CHEBI:22315 ! has primary input alkaloid
@@ -60818,15 +60524,6 @@ intersection_of: GO:0048285 ! organelle fission
intersection_of: GOREL:0002004 GO:0009507 ! results in fission of chloroplast
relationship: GOREL:0002004 GO:0009507 ! results in fission of chloroplast
-[Term]
-id: GO:0010027
-name: thylakoid membrane organization
-comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'.
-is_a: GO:0009668 ! plastid membrane organization
-intersection_of: GO:0016043 ! cellular component organization
-intersection_of: RO:0002592 GO:0042651 ! results in organization of thylakoid membrane
-relationship: RO:0002592 GO:0042651 ! results in organization of thylakoid membrane
-
[Term]
id: GO:0010032
name: meiotic chromosome condensation
@@ -60932,14 +60629,6 @@ intersection_of: GO:0048856 ! anatomical structure development
intersection_of: RO:0002296 PO:0005352 ! results in development of xylem
relationship: RO:0002296 PO:0005352 ! results in development of xylem
-[Term]
-id: GO:0010109
-name: regulation of photosynthesis
-is_a: GO:0031323 ! regulation of cellular metabolic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0015979 ! regulates photosynthesis
-relationship: RO:0002211 GO:0015979 ! regulates photosynthesis
-
[Term]
id: GO:0010121
name: arginine catabolic process to proline via ornithine
@@ -61045,23 +60734,14 @@ is_a: GO:0006810 ! transport
[Term]
id: GO:0010238
name: response to proline
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:26271 ! has primary input proline
relationship: RO:0004009 CHEBI:26271 ! has primary input proline
-[Term]
-id: GO:0010243
-name: response to organonitrogen compound
-comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:1901698 ! response to nitrogen compound
-intersection_of: GO:0050896 ! response to stimulus
-intersection_of: RO:0004009 CHEBI:35352 ! has primary input organonitrogen compound
-relationship: RO:0004009 CHEBI:35352 ! has primary input organonitrogen compound
-
[Term]
id: GO:0010256
name: endomembrane system organization
@@ -61073,10 +60753,10 @@ relationship: RO:0002592 GO:0012505 ! results in organization of endomembrane sy
[Term]
id: GO:0010266
name: response to vitamin B1
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
is_a: GO:0097305 ! response to alcohol
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:18385 ! has primary input thiamine(1+)
relationship: RO:0004009 CHEBI:18385 ! has primary input thiamine(1+)
@@ -61401,23 +61081,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0030168 ! negatively regulates platelet activation
relationship: RO:0002212 GO:0030168 ! negatively regulates platelet activation
-[Term]
-id: GO:0010547
-name: thylakoid membrane disassembly
-is_a: GO:0010027 ! thylakoid membrane organization
-is_a: GO:0030397 ! membrane disassembly
-intersection_of: GO:0022411 ! cellular component disassembly
-intersection_of: RO:0002590 GO:0042651 ! results in disassembly of thylakoid membrane
-relationship: RO:0002590 GO:0042651 ! results in disassembly of thylakoid membrane
-
-[Term]
-id: GO:0010548
-name: regulation of thylakoid membrane disassembly
-is_a: GO:0010549 ! regulation of membrane disassembly
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0010547 ! regulates thylakoid membrane disassembly
-relationship: RO:0002211 GO:0010547 ! regulates thylakoid membrane disassembly
-
[Term]
id: GO:0010549
name: regulation of membrane disassembly
@@ -61557,7 +61220,7 @@ intersection_of: RO:0004009 CHEBI:32678 ! has primary input glutaminate
[Term]
id: GO:0010594
name: regulation of endothelial cell migration
-is_a: GO:0010632 ! regulation of epithelial cell migration
+is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0043542 ! regulates endothelial cell migration
relationship: RO:0002211 GO:0043542 ! regulates endothelial cell migration
@@ -61566,7 +61229,7 @@ relationship: RO:0002211 GO:0043542 ! regulates endothelial cell migration
id: GO:0010595
name: positive regulation of endothelial cell migration
is_a: GO:0010594 ! regulation of endothelial cell migration
-is_a: GO:0010634 ! positive regulation of epithelial cell migration
+is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration
relationship: RO:0002213 GO:0043542 ! positively regulates endothelial cell migration
@@ -61575,7 +61238,7 @@ relationship: RO:0002213 GO:0043542 ! positively regulates endothelial cell migr
id: GO:0010596
name: negative regulation of endothelial cell migration
is_a: GO:0010594 ! regulation of endothelial cell migration
-is_a: GO:0010633 ! negative regulation of epithelial cell migration
+is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration
relationship: RO:0002212 GO:0043542 ! negatively regulates endothelial cell migration
@@ -62353,8 +62016,8 @@ relationship: BFO:0000050 GO:0032509 ! part of endosome transport via multivesic
[Term]
id: GO:0010815
name: bradykinin catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0043603 ! amide metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:132988 ! has primary input bradykinin(2+)
relationship: RO:0004009 CHEBI:132988 ! has primary input bradykinin(2+)
@@ -62364,7 +62027,6 @@ id: GO:0010816
name: calcitonin catabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0043603 ! amide metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:3306 ! has primary input calcitonin
relationship: RO:0004009 CHEBI:3306 ! has primary input calcitonin
@@ -62414,29 +62076,29 @@ relationship: RO:0002211 GO:0007005 ! regulates mitochondrion organization
[Term]
id: GO:0010827
-name: regulation of glucose transmembrane transport
+name: regulation of D-glucose transmembrane transport
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:1904659 ! regulates glucose transmembrane transport
-relationship: RO:0002211 GO:1904659 ! regulates glucose transmembrane transport
+intersection_of: RO:0002211 GO:1904659 ! regulates D-glucose transmembrane transport
+relationship: RO:0002211 GO:1904659 ! regulates D-glucose transmembrane transport
[Term]
id: GO:0010828
-name: positive regulation of glucose transmembrane transport
-is_a: GO:0010827 ! regulation of glucose transmembrane transport
+name: positive regulation of D-glucose transmembrane transport
+is_a: GO:0010827 ! regulation of D-glucose transmembrane transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:1904659 ! positively regulates glucose transmembrane transport
-relationship: RO:0002213 GO:1904659 ! positively regulates glucose transmembrane transport
+intersection_of: RO:0002213 GO:1904659 ! positively regulates D-glucose transmembrane transport
+relationship: RO:0002213 GO:1904659 ! positively regulates D-glucose transmembrane transport
[Term]
id: GO:0010829
-name: negative regulation of glucose transmembrane transport
-is_a: GO:0010827 ! regulation of glucose transmembrane transport
+name: negative regulation of D-glucose transmembrane transport
+is_a: GO:0010827 ! regulation of D-glucose transmembrane transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:1904659 ! negatively regulates glucose transmembrane transport
-relationship: RO:0002212 GO:1904659 ! negatively regulates glucose transmembrane transport
+intersection_of: RO:0002212 GO:1904659 ! negatively regulates D-glucose transmembrane transport
+relationship: RO:0002212 GO:1904659 ! negatively regulates D-glucose transmembrane transport
[Term]
id: GO:0010830
@@ -63540,8 +63202,8 @@ relationship: RO:0004009 CHEBI:24921 ! has primary input isoquinoline alkaloid
[Term]
id: GO:0014074
name: response to purine-containing compound
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:26401 ! has primary input purines
relationship: RO:0004009 CHEBI:26401 ! has primary input purines
@@ -63549,7 +63211,7 @@ relationship: RO:0004009 CHEBI:26401 ! has primary input purines
[Term]
id: GO:0014075
name: response to amine
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
relationship: RO:0004009 CHEBI:32952 ! has primary input amine
@@ -64573,16 +64235,6 @@ intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid z
relationship: BFO:0000050 GO:1902475 ! part of L-alpha-amino acid transmembrane transport
relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
-[Term]
-id: GO:0015180
-name: L-alanine transmembrane transporter activity
-is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
-is_a: GO:0022858 ! alanine transmembrane transporter activity
-intersection_of: GO:0022857 ! transmembrane transporter activity
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-relationship: BFO:0000050 GO:0015808 ! part of L-alanine transport
-relationship: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-
[Term]
id: GO:0015185
name: gamma-aminobutyric acid transmembrane transporter activity
@@ -64679,6 +64331,17 @@ relationship: BFO:0000050 GO:0015825 ! part of L-serine transport
relationship: RO:0000057 CHEBI:33384 ! has participant L-serine zwitterion
relationship: RO:0004009 CHEBI:33384 ! has primary input L-serine zwitterion
+[Term]
+id: GO:0015196
+name: L-tryptophan transmembrane transporter activity
+is_a: GO:0015101 ! organic cation transmembrane transporter activity
+is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
+is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
+intersection_of: GO:0022857 ! transmembrane transporter activity
+intersection_of: RO:0004009 CHEBI:57912 ! has primary input L-tryptophan zwitterion
+relationship: BFO:0000050 GO:0015827 ! part of tryptophan transport
+relationship: RO:0004009 CHEBI:57912 ! has primary input L-tryptophan zwitterion
+
[Term]
id: GO:0015203
name: polyamine transmembrane transporter activity
@@ -64842,7 +64505,10 @@ relationship: RO:0004009 CHEBI:17387 ! has primary input O-acylcarnitine
id: GO:0015228
name: coenzyme A transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity
-is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity
+is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
+is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
+is_a: GO:0042887 ! amide transmembrane transporter activity
+is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
relationship: BFO:0000050 GO:0035349 ! part of coenzyme A transmembrane transport
@@ -65641,27 +65307,6 @@ intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
relationship: RO:0004009 CHEBI:59869 ! has primary input L-alpha-amino acid zwitterion
-[Term]
-id: GO:0015808
-name: L-alanine transport
-is_a: GO:0015807 ! L-amino acid transport
-is_a: GO:0032328 ! alanine transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-relationship: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-
-[Term]
-id: GO:0015810
-name: aspartate transmembrane transport
-is_a: GO:0003333 ! amino acid transmembrane transport
-is_a: GO:0015740 ! C4-dicarboxylate transport
-is_a: GO:0071705 ! nitrogen compound transport
-is_a: GO:1905039 ! carboxylic acid transmembrane transport
-intersection_of: GO:0055085 ! transmembrane transport
-intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-relationship: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-
[Term]
id: GO:0015812
name: gamma-aminobutyric acid transport
@@ -66089,8 +65734,10 @@ relationship: RO:0004009 CHEBI:17126 ! has primary input carnitine
id: GO:0015880
name: coenzyme A transport
is_a: GO:0015711 ! organic anion transport
-is_a: GO:0015868 ! purine ribonucleotide transport
-is_a: GO:0051503 ! adenine nucleotide transport
+is_a: GO:0015748 ! organophosphate ester transport
+is_a: GO:0015931 ! nucleobase-containing compound transport
+is_a: GO:0042886 ! amide transport
+is_a: GO:0072348 ! sulfur compound transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
relationship: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
@@ -66227,9 +65874,9 @@ relationship: RO:0004009 CHEBI:16247 ! has primary input phospholipid
id: GO:0015916
name: fatty-acyl-CoA transport
is_a: GO:0015711 ! organic anion transport
-is_a: GO:0015868 ! purine ribonucleotide transport
+is_a: GO:0015748 ! organophosphate ester transport
+is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0042886 ! amide transport
-is_a: GO:0051503 ! adenine nucleotide transport
is_a: GO:1901337 ! thioester transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:58342 ! has primary input acyl-CoA(4-)
@@ -66272,9 +65919,10 @@ relationship: RO:0004009 CHEBI:61120 ! has primary input nucleobase-containing m
[Term]
id: GO:0015936
name: coenzyme A metabolic process
-is_a: GO:0009150 ! purine ribonucleotide metabolic process
-is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
-is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
+is_a: GO:0006753 ! nucleoside phosphate metabolic process
+is_a: GO:0006790 ! sulfur compound metabolic process
+is_a: GO:0043603 ! amide metabolic process
+is_a: GO:0072521 ! purine-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:57287 ! has primary input or output coenzyme A(4-)
relationship: RO:0004007 CHEBI:57287 ! has primary input or output coenzyme A(4-)
@@ -66282,10 +65930,11 @@ relationship: RO:0004007 CHEBI:57287 ! has primary input or output coenzyme A(4-
[Term]
id: GO:0015937
name: coenzyme A biosynthetic process
-is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015936 ! coenzyme A metabolic process
-is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
-is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
+is_a: GO:0043604 ! amide biosynthetic process
+is_a: GO:0044272 ! sulfur compound biosynthetic process
+is_a: GO:0072522 ! purine-containing compound biosynthetic process
+is_a: GO:1901293 ! nucleoside phosphate biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:57287 ! has primary output coenzyme A(4-)
relationship: RO:0004008 CHEBI:57287 ! has primary output coenzyme A(4-)
@@ -66293,10 +65942,10 @@ relationship: RO:0004008 CHEBI:57287 ! has primary output coenzyme A(4-)
[Term]
id: GO:0015938
name: coenzyme A catabolic process
-is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015936 ! coenzyme A metabolic process
-is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
-is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
+is_a: GO:0044273 ! sulfur compound catabolic process
+is_a: GO:0072523 ! purine-containing compound catabolic process
+is_a: GO:1901292 ! nucleoside phosphate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
relationship: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
@@ -66350,11 +65999,6 @@ id: GO:0015975
name: energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0006091 ! generation of precursor metabolites and energy
-[Term]
-id: GO:0015979
-name: photosynthesis
-is_a: GO:0044237 ! cellular metabolic process
-
[Term]
id: GO:0015980
name: energy derivation by oxidation of organic compounds
@@ -66943,7 +66587,7 @@ relationship: RO:0002578 GO:0015267 ! directly regulates channel activity
[Term]
id: GO:0016298
name: lipase activity
-is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
+is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
id: GO:0016301
@@ -67268,16 +66912,6 @@ id: GO:0016607
name: nuclear speck
is_a: GO:0016604 ! nuclear body
-[Term]
-id: GO:0016614
-name: oxidoreductase activity, acting on CH-OH group of donors
-is_a: GO:0016491 ! oxidoreductase activity
-
-[Term]
-id: GO:0016616
-name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
-is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
-
[Term]
id: GO:0016620
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
@@ -67370,11 +67004,6 @@ id: GO:0016743
name: carboxyl- or carbamoyltransferase activity
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups
-[Term]
-id: GO:0016744
-name: transketolase or transaldolase activity
-is_a: GO:0016740 ! transferase activity
-
[Term]
id: GO:0016746
name: acyltransferase activity
@@ -68161,26 +67790,6 @@ intersection_of: RO:0004008 CHEBI:32660 ! has primary output asparaginate
intersection_of: RO:0004009 CHEBI:35237 ! has primary input cysteine zwitterion
relationship: RO:0004009 CHEBI:35237 ! has primary input cysteine zwitterion
-[Term]
-id: GO:0019272
-name: L-alanine biosynthetic process from pyruvate
-is_a: GO:0006090 ! pyruvate metabolic process
-is_a: GO:0042852 ! L-alanine biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:57972 ! has primary output L-alanine zwitterion
-intersection_of: RO:0004009 CHEBI:15361 ! has primary input pyruvate
-relationship: RO:0004009 CHEBI:15361 ! has primary input pyruvate
-
-[Term]
-id: GO:0019273
-name: L-alanine biosynthetic process via ornithine
-is_a: GO:0006591 ! ornithine metabolic process
-is_a: GO:0042852 ! L-alanine biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0002505 CHEBI:46912 ! has intermediate ornithinium(1+)
-intersection_of: RO:0004008 CHEBI:57972 ! has primary output L-alanine zwitterion
-relationship: RO:0002505 CHEBI:46912 ! has intermediate ornithinium(1+)
-
[Term]
id: GO:0019293
name: tyrosine biosynthetic process, by oxidation of phenylalanine
@@ -68300,8 +67909,10 @@ relationship: RO:0004008 CHEBI:35237 ! has primary output cysteine zwitterion
[Term]
id: GO:0019356
name: nicotinate nucleotide biosynthetic process from tryptophan
-is_a: GO:0006568 ! tryptophan metabolic process
+is_a: GO:0006586 ! indolalkylamine metabolic process
+is_a: GO:0009072 ! aromatic amino acid metabolic process
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process
+is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:25534 ! has primary output nicotinic acid nucleotide
intersection_of: RO:0004009 CHEBI:64554 ! has primary input tryptophan zwitterion
@@ -68366,7 +67977,7 @@ relationship: RO:0004009 CHEBI:36980 ! has primary input pyridine nucleotide
[Term]
id: GO:0019369
-name: arachidonic acid metabolic process
+name: arachidonate metabolic process
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
@@ -68616,18 +68227,6 @@ intersection_of: RO:0004008 CHEBI:57292 ! has primary output succinyl-CoA(5-)
intersection_of: RO:0004009 CHEBI:64558 ! has primary input methionine zwitterion
relationship: RO:0004008 CHEBI:57292 ! has primary output succinyl-CoA(5-)
-[Term]
-id: GO:0019460
-name: glutamine catabolic process to fumarate
-is_a: GO:0006106 ! fumarate metabolic process
-is_a: GO:0006538 ! glutamate catabolic process
-is_a: GO:0006543 ! glutamine catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004008 CHEBI:29806 ! has primary output fumarate(2-)
-intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-relationship: BFO:0000051 GO:0019550 ! has part glutamate catabolic process to aspartate
-relationship: RO:0004008 CHEBI:29806 ! has primary output fumarate(2-)
-
[Term]
id: GO:0019463
name: glycine catabolic process to creatine
@@ -68770,16 +68369,6 @@ intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:57966 ! has primary input beta-alanine zwitterion
relationship: RO:0004009 CHEBI:57966 ! has primary input beta-alanine zwitterion
-[Term]
-id: GO:0019485
-name: beta-alanine catabolic process to L-alanine
-is_a: GO:0019484 ! beta-alanine catabolic process
-is_a: GO:0042851 ! L-alanine metabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004008 CHEBI:57972 ! has primary output L-alanine zwitterion
-intersection_of: RO:0004009 CHEBI:57966 ! has primary input beta-alanine zwitterion
-relationship: RO:0004008 CHEBI:57972 ! has primary output L-alanine zwitterion
-
[Term]
id: GO:0019493
name: arginine catabolic process to proline
@@ -68844,7 +68433,6 @@ id: GO:0019529
name: taurine catabolic process
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0046306 ! alkanesulfonate catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:507393 ! has primary input taurine zwitterion
relationship: RO:0004009 CHEBI:507393 ! has primary input taurine zwitterion
@@ -68853,7 +68441,6 @@ relationship: RO:0004009 CHEBI:507393 ! has primary input taurine zwitterion
id: GO:0019530
name: taurine metabolic process
is_a: GO:0019694 ! alkanesulfonate metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:507393 ! has primary input or output taurine zwitterion
relationship: RO:0004007 CHEBI:507393 ! has primary input or output taurine zwitterion
@@ -68881,7 +68468,6 @@ name: protein metabolic process
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
[Term]
id: GO:0019541
@@ -68949,39 +68535,6 @@ intersection_of: RO:0004008 CHEBI:45725 ! has primary output spermine(4+)
intersection_of: RO:0004009 CHEBI:32696 ! has primary input argininium(1+)
relationship: RO:0004008 CHEBI:45725 ! has primary output spermine(4+)
-[Term]
-id: GO:0019549
-name: glutamate catabolic process to succinate via succinate semialdehyde
-comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants.
-is_a: GO:0006540 ! glutamate decarboxylation to succinate
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0002505 CHEBI:57706 ! has intermediate 4-oxobutanoate
-intersection_of: RO:0004008 CHEBI:30031 ! has primary output succinate(2-)
-intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-relationship: BFO:0000051 GO:0034387 ! has part 4-aminobutyrate:pyruvate transaminase activity
-relationship: RO:0002505 CHEBI:57706 ! has intermediate 4-oxobutanoate
-
-[Term]
-id: GO:0019550
-name: glutamate catabolic process to aspartate
-is_a: GO:0006531 ! aspartate metabolic process
-is_a: GO:0006538 ! glutamate catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004008 CHEBI:35391 ! has primary output aspartate(1-)
-intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-relationship: RO:0004008 CHEBI:35391 ! has primary output aspartate(1-)
-
-[Term]
-id: GO:0019551
-name: glutamate catabolic process to 2-oxoglutarate
-is_a: GO:0006103 ! 2-oxoglutarate metabolic process
-is_a: GO:0006106 ! fumarate metabolic process
-is_a: GO:0006538 ! glutamate catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004008 CHEBI:16810 ! has primary output 2-oxoglutarate(2-)
-intersection_of: RO:0004009 CHEBI:14321 ! has primary input glutamate(1-)
-relationship: RO:0004008 CHEBI:16810 ! has primary output 2-oxoglutarate(2-)
-
[Term]
id: GO:0019554
name: glutamate catabolic process to oxaloacetate
@@ -69097,7 +68650,6 @@ name: urea metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0071941 ! nitrogen cycle metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:16199 ! has primary input or output urea
relationship: RO:0004007 CHEBI:16199 ! has primary input or output urea
@@ -69228,15 +68780,6 @@ intersection_of: GO:0006113 ! fermentation
intersection_of: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
relationship: RO:0004009 CHEBI:51143 ! has primary input nitrogen molecular entity
-[Term]
-id: GO:0019667
-name: anaerobic L-alanine catabolic process
-is_a: GO:0019665 ! anaerobic amino acid catabolic process
-is_a: GO:0019666 ! nitrogenous compound fermentation
-is_a: GO:0042853 ! L-alanine catabolic process
-intersection_of: GO:0019665 ! anaerobic amino acid catabolic process
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-
[Term]
id: GO:0019669
name: anaerobic glycine catabolic process
@@ -73087,7 +72630,6 @@ id: GO:0030148
name: sphingolipid biosynthetic process
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26739 ! has primary output sphingolipid
relationship: RO:0004008 CHEBI:26739 ! has primary output sphingolipid
@@ -73097,7 +72639,6 @@ id: GO:0030149
name: sphingolipid catabolic process
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:26739 ! has primary input sphingolipid
relationship: RO:0004009 CHEBI:26739 ! has primary input sphingolipid
@@ -73140,7 +72681,6 @@ name: protein catabolic process
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0019538 ! protein metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
[Term]
id: GO:0030166
@@ -74147,16 +73687,6 @@ is_a: GO:0060326 ! cell chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0002565 CL:0000738 ! results in movement of leukocyte
-[Term]
-id: GO:0030632
-name: D-alanine biosynthetic process
-is_a: GO:0006523 ! alanine biosynthetic process
-is_a: GO:0046436 ! D-alanine metabolic process
-is_a: GO:0046437 ! D-amino acid biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:57416 ! has primary output D-alanine zwitterion
-relationship: RO:0004008 CHEBI:57416 ! has primary output D-alanine zwitterion
-
[Term]
id: GO:0030638
name: polyketide metabolic process
@@ -74230,7 +73760,6 @@ name: peptide antibiotic metabolic process
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043603 ! amide metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:25903 ! has primary input or output peptide antibiotic
relationship: RO:0004007 CHEBI:25903 ! has primary input or output peptide antibiotic
@@ -74242,7 +73771,6 @@ is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:25903 ! has primary output peptide antibiotic
relationship: RO:0004008 CHEBI:25903 ! has primary output peptide antibiotic
@@ -74253,7 +73781,6 @@ name: peptide antibiotic catabolic process
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043171 ! peptide catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:25903 ! has primary input peptide antibiotic
relationship: RO:0004009 CHEBI:25903 ! has primary input peptide antibiotic
@@ -75676,8 +75203,8 @@ relationship: BFO:0000066 CL:0000362 ! occurs in epidermal cell
[Term]
id: GO:0031427
name: response to methotrexate
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:50681 ! has primary input methotrexate(2-)
@@ -75709,6 +75236,7 @@ relationship: RO:0004009 PR:000016156 ! has primary input telethonin
id: GO:0031491
name: nucleosome binding
is_a: GO:0003682 ! chromatin binding
+is_a: GO:0044877 ! protein-containing complex binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 GO:0000786 ! has primary input nucleosome
relationship: RO:0004009 GO:0000786 ! has primary input nucleosome
@@ -76273,14 +75801,6 @@ name: membrane-enclosed lumen
is_a: GO:0110165 ! cellular anatomical entity
disjoint_from: GO:0045202 ! synapse
-[Term]
-id: GO:0031976
-name: plastid thylakoid
-is_a: GO:0009579 ! thylakoid
-intersection_of: GO:0009579 ! thylakoid
-intersection_of: BFO:0000050 GO:0009536 ! part of plastid
-relationship: BFO:0000050 GO:0009536 ! part of plastid
-
[Term]
id: GO:0031981
name: nuclear lumen
@@ -76574,8 +76094,8 @@ name: 4-aminobutyrate transaminase complex
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex
intersection_of: GO:1902494 ! catalytic complex
-intersection_of: RO:0002215 GO:0003867 ! capable of 4-aminobutyrate transaminase activity
-relationship: RO:0002215 GO:0003867 ! capable of 4-aminobutyrate transaminase activity
+intersection_of: RO:0002215 GO:0034386 ! capable of 4-aminobutyrate:2-oxoglutarate transaminase activity
+relationship: RO:0002215 GO:0034386 ! capable of 4-aminobutyrate:2-oxoglutarate transaminase activity
[Term]
id: GO:0032156
@@ -78047,7 +77567,6 @@ id: GO:0032605
name: hepatocyte growth factor production
is_a: GO:0001816 ! cytokine production
is_a: GO:0019538 ! protein metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0004008 PR:000008534 ! has primary output hepatocyte growth factor
relationship: RO:0004008 PR:000008534 ! has primary output hepatocyte growth factor
@@ -78181,7 +77700,6 @@ name: lymphotoxin A production
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0001816 ! cytokine production
intersection_of: RO:0004008 PR:000002204 ! has primary output lymphotoxin-alpha
relationship: RO:0004008 PR:000002204 ! has primary output lymphotoxin-alpha
@@ -79774,7 +79292,7 @@ relationship: BFO:0000050 GO:0048471 ! part of perinuclear region of cytoplasm
[Term]
id: GO:0033013
name: tetrapyrrole metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26932 ! has primary input or output tetrapyrrole
relationship: RO:0004007 CHEBI:26932 ! has primary input or output tetrapyrrole
@@ -79782,8 +79300,8 @@ relationship: RO:0004007 CHEBI:26932 ! has primary input or output tetrapyrrole
[Term]
id: GO:0033014
name: tetrapyrrole biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26932 ! has primary output tetrapyrrole
relationship: RO:0004008 CHEBI:26932 ! has primary output tetrapyrrole
@@ -79791,8 +79309,8 @@ relationship: RO:0004008 CHEBI:26932 ! has primary output tetrapyrrole
[Term]
id: GO:0033015
name: tetrapyrrole catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:26932 ! has primary input tetrapyrrole
relationship: RO:0004009 CHEBI:26932 ! has primary input tetrapyrrole
@@ -80570,6 +80088,12 @@ is_a: GO:0071173 ! spindle assembly checkpoint signaling
intersection_of: GO:0071173 ! spindle assembly checkpoint signaling
intersection_of: BFO:0000050 GO:0051321 ! part of meiotic cell cycle
+[Term]
+id: GO:0033326
+name: cerebrospinal fluid secretion
+is_a: GO:0007589 ! body fluid secretion
+is_a: GO:0032941 ! secretion by tissue
+
[Term]
id: GO:0033327
name: Leydig cell differentiation
@@ -80794,7 +80318,6 @@ relationship: RO:0004009 CHEBI:57305 ! has primary input glycine zwitterion
[Term]
id: GO:0033554
name: cellular response to stress
-comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
is_a: GO:0006950 ! response to stress
is_a: GO:0051716 ! cellular response to stimulus
@@ -80854,9 +80377,9 @@ relationship: RO:0004009 CHEBI:17347 ! has primary input testosterone
[Term]
id: GO:0033590
name: response to cobalamin
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:30411 ! has primary input cobalamin
@@ -80975,21 +80498,21 @@ relationship: RO:0004009 CHEBI:30623 ! has primary input oxalate(2-)
id: GO:0033614
name: chloroplast proton-transporting ATP synthase complex assembly
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
-intersection_of: GO:0022607 ! cellular component assembly
-intersection_of: RO:0002588 GO:0045320 ! results in assembly of chloroplast proton-transporting ATP synthase complex
+intersection_of: GO:0043461 ! proton-transporting ATP synthase complex assembly
+intersection_of: BFO:0000066 GO:0009507 ! occurs in chloroplast
relationship: BFO:0000050 GO:0009658 ! part of chloroplast organization
+relationship: BFO:0000066 GO:0009507 ! occurs in chloroplast
relationship: RO:0002160 NCBITaxon:33090 ! only in taxon Viridiplantae
relationship: RO:0002162 NCBITaxon:33090 {all_only="true"} ! in taxon Viridiplantae
-relationship: RO:0002588 GO:0045320 ! results in assembly of chloroplast proton-transporting ATP synthase complex
[Term]
id: GO:0033615
name: mitochondrial proton-transporting ATP synthase complex assembly
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
+is_a: GO:0097250 ! mitochondrial respirasome assembly
intersection_of: GO:0043461 ! proton-transporting ATP synthase complex assembly
intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: BFO:0000050 GO:0007005 ! part of mitochondrion organization
-relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
relationship: RO:0002160 NCBITaxon:2759 ! only in taxon Eukaryota
relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! in taxon Eukaryota
@@ -80997,10 +80520,10 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! in taxon Eukaryota
id: GO:0033616
name: plasma membrane proton-transporting ATP synthase complex assembly
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
-intersection_of: GO:0022607 ! cellular component assembly
-intersection_of: RO:0002588 GO:0045260 ! results in assembly of plasma membrane proton-transporting ATP synthase complex
+intersection_of: GO:0043461 ! proton-transporting ATP synthase complex assembly
+intersection_of: BFO:0000066 GO:0005886 ! occurs in plasma membrane
relationship: BFO:0000050 GO:0007009 ! part of plasma membrane organization
-relationship: RO:0002588 GO:0045260 ! results in assembly of plasma membrane proton-transporting ATP synthase complex
+relationship: BFO:0000066 GO:0005886 ! occurs in plasma membrane
[Term]
id: GO:0033673
@@ -81107,45 +80630,6 @@ intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:5391 ! has primary input glucagon
relationship: RO:0004009 CHEBI:5391 ! has primary input glucagon
-[Term]
-id: GO:0033865
-name: nucleoside bisphosphate metabolic process
-is_a: GO:0006753 ! nucleoside phosphate metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:37123 ! has primary input or output nucleoside bisphosphate
-relationship: RO:0004007 CHEBI:37123 ! has primary input or output nucleoside bisphosphate
-
-[Term]
-id: GO:0033866
-name: nucleoside bisphosphate biosynthetic process
-is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
-is_a: GO:1901293 ! nucleoside phosphate biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:37123 ! has primary output nucleoside bisphosphate
-relationship: RO:0004008 CHEBI:37123 ! has primary output nucleoside bisphosphate
-
-[Term]
-id: GO:0033869
-name: nucleoside bisphosphate catabolic process
-is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
-is_a: GO:1901292 ! nucleoside phosphate catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:37123 ! has primary input nucleoside bisphosphate
-relationship: RO:0004009 CHEBI:37123 ! has primary input nucleoside bisphosphate
-
-[Term]
-id: GO:0033875
-name: ribonucleoside bisphosphate metabolic process
-is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:61079 ! has primary input or output ribonucleoside bisphosphate
-relationship: RO:0004007 CHEBI:61079 ! has primary input or output ribonucleoside bisphosphate
-
-[Term]
-id: GO:0033878
-name: hormone-sensitive lipase activity
-is_a: GO:0052689 ! carboxylic ester hydrolase activity
-
[Term]
id: GO:0033986
name: response to methanol
@@ -81179,53 +80663,6 @@ intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:30563 ! has primary input silicon dioxide
relationship: RO:0004009 CHEBI:30563 ! has primary input silicon dioxide
-[Term]
-id: GO:0034030
-name: ribonucleoside bisphosphate biosynthetic process
-is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
-is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:61079 ! has primary output ribonucleoside bisphosphate
-relationship: RO:0004008 CHEBI:61079 ! has primary output ribonucleoside bisphosphate
-
-[Term]
-id: GO:0034031
-name: ribonucleoside bisphosphate catabolic process
-is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
-is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:61079 ! has primary input ribonucleoside bisphosphate
-relationship: RO:0004009 CHEBI:61079 ! has primary input ribonucleoside bisphosphate
-
-[Term]
-id: GO:0034032
-name: purine nucleoside bisphosphate metabolic process
-is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
-is_a: GO:0072521 ! purine-containing compound metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:61078 ! has primary input or output purine nucleoside bisphosphate
-relationship: RO:0004007 CHEBI:61078 ! has primary input or output purine nucleoside bisphosphate
-
-[Term]
-id: GO:0034033
-name: purine nucleoside bisphosphate biosynthetic process
-is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
-is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
-is_a: GO:0072522 ! purine-containing compound biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:61078 ! has primary output purine nucleoside bisphosphate
-relationship: RO:0004008 CHEBI:61078 ! has primary output purine nucleoside bisphosphate
-
-[Term]
-id: GO:0034034
-name: purine nucleoside bisphosphate catabolic process
-is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
-is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
-is_a: GO:0072523 ! purine-containing compound catabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:61078 ! has primary input purine nucleoside bisphosphate
-relationship: RO:0004009 CHEBI:61078 ! has primary input purine nucleoside bisphosphate
-
[Term]
id: GO:0034067
name: protein localization to Golgi apparatus
@@ -81594,7 +81031,6 @@ relationship: RO:0002211 GO:0019627 ! regulates urea metabolic process
id: GO:0034275
name: kynurenic acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:58454 ! has primary input or output kynurenate
relationship: RO:0004007 CHEBI:58454 ! has primary input or output kynurenate
@@ -81604,7 +81040,6 @@ id: GO:0034276
name: kynurenic acid biosynthetic process
is_a: GO:0034275 ! kynurenic acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:58454 ! has primary output kynurenate
relationship: RO:0004008 CHEBI:58454 ! has primary output kynurenate
@@ -81737,13 +81172,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process
relationship: RO:0002213 GO:0034349 ! positively regulates glial cell apoptotic process
-[Term]
-id: GO:0034357
-name: photosynthetic membrane
-is_a: GO:0016020 ! membrane
-relationship: BFO:0000050 GO:0009579 ! part of thylakoid
-relationship: RO:0002216 GO:0015979 ! capable of part of photosynthesis
-
[Term]
id: GO:0034358
name: plasma lipoprotein particle
@@ -81809,11 +81237,13 @@ relationship: BFO:0000051 CHEBI:17855 ! has part triglyceride
relationship: BFO:0000051 CHEBI:39015 ! has part apolipoprotein
[Term]
-id: GO:0034387
-name: 4-aminobutyrate:pyruvate transaminase activity
-is_a: GO:0003867 ! 4-aminobutyrate transaminase activity
-relationship: RO:0000057 CHEBI:15361 ! has participant pyruvate
-relationship: RO:0000057 CHEBI:57972 ! has participant L-alanine zwitterion
+id: GO:0034386
+name: 4-aminobutyrate:2-oxoglutarate transaminase activity
+is_a: GO:0008483 ! transaminase activity
+relationship: RO:0000057 CHEBI:16810 ! has participant 2-oxoglutarate(2-)
+relationship: RO:0000057 CHEBI:29985 ! has participant L-glutamate(1-)
+relationship: RO:0000057 CHEBI:57706 ! has participant 4-oxobutanoate
+relationship: RO:0000057 CHEBI:59888 ! has participant gamma-aminobutyric acid zwitterion
[Term]
id: GO:0034389
@@ -82067,21 +81497,6 @@ intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:32696 ! has primary input argininium(1+)
relationship: RO:0004009 CHEBI:32696 ! has primary input argininium(1+)
-[Term]
-id: GO:0034627
-name: 'de novo' NAD biosynthetic process
-is_a: GO:0009435 ! NAD biosynthetic process
-
-[Term]
-id: GO:0034628
-name: 'de novo' NAD biosynthetic process from aspartate
-is_a: GO:0006531 ! aspartate metabolic process
-is_a: GO:0034627 ! 'de novo' NAD biosynthetic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:25527 ! has primary output nicotinamide nucleotide
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-relationship: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-
[Term]
id: GO:0034632
name: retinol transmembrane transporter activity
@@ -82132,7 +81547,6 @@ id: GO:0034638
name: phosphatidylcholine catabolic process
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:64482 ! has primary input phosphatidylcholine
relationship: RO:0004009 CHEBI:64482 ! has primary input phosphatidylcholine
@@ -82208,7 +81622,7 @@ is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
[Term]
id: GO:0034670
-name: chemotaxis to arachidonic acid
+name: chemotaxis to arachidonate
is_a: GO:0006935 ! chemotaxis
intersection_of: GO:0006935 ! chemotaxis
intersection_of: RO:0004009 CHEBI:32395 ! has primary input arachidonate
@@ -82292,6 +81706,7 @@ relationship: RO:0002215 GO:0008168 ! capable of methyltransferase activity
id: GO:0034728
name: nucleosome organization
is_a: GO:0006338 ! chromatin remodeling
+is_a: GO:0071824 ! protein-DNA complex organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: RO:0002592 GO:0000786 ! results in organization of nucleosome
relationship: RO:0002592 GO:0000786 ! results in organization of nucleosome
@@ -82442,8 +81857,8 @@ intersection_of: RO:0004009 CHEBI:57925 ! has primary input glutathionate(1-)
[Term]
id: GO:0034776
name: response to histamine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:58432 ! has primary input histaminium
relationship: RO:0004009 CHEBI:58432 ! has primary input histaminium
@@ -83070,7 +82485,7 @@ id: GO:0035348
name: acetyl-CoA transmembrane transport
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
is_a: GO:0015876 ! acetyl-CoA transport
-is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport
+is_a: GO:0072530 ! purine-containing compound transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:57288 ! has primary input acetyl-CoA(4-)
@@ -83080,7 +82495,7 @@ id: GO:0035349
name: coenzyme A transmembrane transport
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
is_a: GO:0015880 ! coenzyme A transport
-is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport
+is_a: GO:0072530 ! purine-containing compound transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
@@ -84697,11 +84112,10 @@ relationship: RO:0004009 CHEBI:62942 ! has primary input leukotriene anion
[Term]
id: GO:0036115
name: fatty-acyl-CoA catabolic process
-is_a: GO:0009154 ! purine ribonucleotide catabolic process
-is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
-is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0035337 ! fatty-acyl-CoA metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
+is_a: GO:0072523 ! purine-containing compound catabolic process
+is_a: GO:1901292 ! nucleoside phosphate catabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:77636 ! has primary input fatty acyl-CoA(4-)
@@ -84867,8 +84281,8 @@ relationship: RO:0004009 CHEBI:6887 ! has primary input methylphenidate
id: GO:0036272
name: response to gemcitabine
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:175901 ! has primary input gemcitabine
@@ -84887,8 +84301,8 @@ relationship: RO:0004009 CHEBI:87631 ! has primary input statin
id: GO:0036274
name: response to lapatinib
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:49603 ! has primary input lapatinib
@@ -84919,8 +84333,8 @@ relationship: RO:0004009 CHEBI:65173 ! has primary input iloperidone
id: GO:0036288
name: response to ximelagatran
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:65172 ! has primary input ximelagatran
@@ -85054,8 +84468,8 @@ relationship: RO:0002299 CL:0000233 ! results in maturation of platelet
id: GO:0036346
name: cellular response to L-cysteine
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901367 ! response to L-cysteine
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:35235 ! has primary input L-cysteine zwitterion
@@ -85200,9 +84614,9 @@ intersection_of: RO:0002212 GO:0006413 ! negatively regulates translational init
id: GO:0036503
name: ERAD pathway
comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0010498 ! proteasomal protein catabolic process
is_a: GO:0034976 ! response to endoplasmic reticulum stress
+is_a: GO:1901698 ! response to nitrogen compound
[Term]
id: GO:0036504
@@ -85720,7 +85134,7 @@ intersection_of: RO:0002342 UBERON:0000483 ! results in transport across epithel
[Term]
id: GO:0042049
name: intracellular acyl-CoA homeostasis
-is_a: GO:0140979 ! intracellular nucleotide homeostasis
+is_a: GO:0055082 ! intracellular chemical homeostasis
intersection_of: GO:0019725 ! cellular homeostasis
intersection_of: RO:0002332 CHEBI:58342 ! regulates levels of acyl-CoA(4-)
relationship: RO:0002332 CHEBI:58342 ! regulates levels of acyl-CoA(4-)
@@ -85995,7 +85409,6 @@ id: GO:0042158
name: lipoprotein biosynthetic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0042157 ! lipoprotein metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:6495 ! has primary output lipoprotein
relationship: RO:0004008 CHEBI:6495 ! has primary output lipoprotein
@@ -86179,7 +85592,7 @@ relationship: RO:0004007 CHEBI:35186 ! has primary input or output terpene
id: GO:0042219
name: cellular modified amino acid catabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
+is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:83821 ! has primary input amino acid derivative
relationship: RO:0004009 CHEBI:83821 ! has primary input amino acid derivative
@@ -86562,7 +85975,7 @@ relationship: RO:0004009 CHEBI:64618 ! has primary input phosphagen
id: GO:0042398
name: cellular modified amino acid biosynthetic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:83821 ! has primary output amino acid derivative
relationship: RO:0004008 CHEBI:83821 ! has primary output amino acid derivative
@@ -86598,7 +86011,6 @@ id: GO:0042412
name: taurine biosynthetic process
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0046305 ! alkanesulfonate biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:507393 ! has primary output taurine zwitterion
relationship: RO:0002160 NCBITaxon:33208 ! only in taxon Metazoa
@@ -86766,7 +86178,7 @@ relationship: RO:0004009 CHEBI:350546 ! has primary input serotonin(1+)
[Term]
id: GO:0042430
name: indole-containing compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:24828 ! has primary input or output indoles
relationship: RO:0004007 CHEBI:24828 ! has primary input or output indoles
@@ -86800,8 +86212,8 @@ relationship: RO:0004009 CHEBI:35581 ! has primary input indole
[Term]
id: GO:0042435
name: indole-containing compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042430 ! indole-containing compound metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:24828 ! has primary output indoles
relationship: RO:0004008 CHEBI:24828 ! has primary output indoles
@@ -86809,8 +86221,8 @@ relationship: RO:0004008 CHEBI:24828 ! has primary output indoles
[Term]
id: GO:0042436
name: indole-containing compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:24828 ! has primary input indoles
relationship: RO:0004009 CHEBI:24828 ! has primary input indoles
@@ -86900,12 +86312,14 @@ relationship: RO:0004007 CHEBI:17026 ! has primary input or output progesterone
[Term]
id: GO:0042450
name: arginine biosynthetic process via ornithine
-is_a: GO:0006526 ! arginine biosynthetic process
+is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0006591 ! ornithine metabolic process
+is_a: GO:1901607 ! alpha-amino acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0002505 CHEBI:46912 ! has intermediate ornithinium(1+)
intersection_of: RO:0004008 CHEBI:32696 ! has primary output argininium(1+)
relationship: RO:0002505 CHEBI:46912 ! has intermediate ornithinium(1+)
+relationship: RO:0004008 CHEBI:32696 ! has primary output argininium(1+)
[Term]
id: GO:0042451
@@ -87151,7 +86565,6 @@ id: GO:0042541
name: hemoglobin biosynthetic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0020027 ! hemoglobin metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:35143 ! has primary output hemoglobin
relationship: RO:0002160 NCBITaxon:6072 ! only in taxon Eumetazoa
@@ -87183,7 +86596,7 @@ is_a: GO:0008366 ! axon ensheathment
[Term]
id: GO:0042558
name: pteridine-containing compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26373 ! has primary input or output pteridines
relationship: RO:0004007 CHEBI:26373 ! has primary input or output pteridines
@@ -87191,8 +86604,8 @@ relationship: RO:0004007 CHEBI:26373 ! has primary input or output pteridines
[Term]
id: GO:0042559
name: pteridine-containing compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26373 ! has primary output pteridines
relationship: RO:0004008 CHEBI:26373 ! has primary output pteridines
@@ -87200,8 +86613,8 @@ relationship: RO:0004008 CHEBI:26373 ! has primary output pteridines
[Term]
id: GO:0042560
name: pteridine-containing compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:26373 ! has primary input pteridines
relationship: RO:0004009 CHEBI:26373 ! has primary input pteridines
@@ -87433,11 +86846,6 @@ intersection_of: GO:0005694 ! chromosome
intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
relationship: BFO:0000050 GO:0042644 ! part of chloroplast nucleoid
-[Term]
-id: GO:0042651
-name: thylakoid membrane
-is_a: GO:0034357 ! photosynthetic membrane
-
[Term]
id: GO:0042659
name: regulation of cell fate specification
@@ -87851,35 +87259,6 @@ name: platelet dense granule
is_a: GO:0030141 ! secretory granule
relationship: BFO:0000050 CL:0000233 ! part of platelet
-[Term]
-id: GO:0042851
-name: L-alanine metabolic process
-is_a: GO:0006522 ! alanine metabolic process
-is_a: GO:0009078 ! pyruvate family amino acid metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:57972 ! has primary input or output L-alanine zwitterion
-relationship: RO:0004007 CHEBI:57972 ! has primary input or output L-alanine zwitterion
-
-[Term]
-id: GO:0042852
-name: L-alanine biosynthetic process
-is_a: GO:0006523 ! alanine biosynthetic process
-is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process
-is_a: GO:0042851 ! L-alanine metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:57972 ! has primary output L-alanine zwitterion
-relationship: RO:0004008 CHEBI:57972 ! has primary output L-alanine zwitterion
-
-[Term]
-id: GO:0042853
-name: L-alanine catabolic process
-is_a: GO:0006524 ! alanine catabolic process
-is_a: GO:0009080 ! pyruvate family amino acid catabolic process
-is_a: GO:0042851 ! L-alanine metabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-relationship: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-
[Term]
id: GO:0042866
name: pyruvate biosynthetic process
@@ -88047,18 +87426,6 @@ intersection_of: GO:0006810 ! transport
intersection_of: RO:0004009 CHEBI:59871 ! has primary input D-alpha-amino acid zwitterion
relationship: RO:0004009 CHEBI:59871 ! has primary input D-alpha-amino acid zwitterion
-[Term]
-id: GO:0042941
-name: D-alanine transmembrane transport
-is_a: GO:0003333 ! amino acid transmembrane transport
-is_a: GO:0032328 ! alanine transport
-is_a: GO:0042940 ! D-amino acid transport
-is_a: GO:1905039 ! carboxylic acid transmembrane transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
-intersection_of: RO:0004009 CHEBI:57416 ! has primary input D-alanine zwitterion
-relationship: RO:0004009 CHEBI:57416 ! has primary input D-alanine zwitterion
-
[Term]
id: GO:0042942
name: D-serine transmembrane transport
@@ -88081,16 +87448,6 @@ intersection_of: RO:0004009 CHEBI:59871 ! has primary input D-alpha-amino acid z
relationship: BFO:0000050 GO:0042940 ! part of D-amino acid transport
relationship: RO:0004009 CHEBI:59871 ! has primary input D-alpha-amino acid zwitterion
-[Term]
-id: GO:0042944
-name: D-alanine transmembrane transporter activity
-is_a: GO:0022858 ! alanine transmembrane transporter activity
-is_a: GO:0042943 ! D-amino acid transmembrane transporter activity
-intersection_of: GO:0022857 ! transmembrane transporter activity
-intersection_of: RO:0004009 CHEBI:57416 ! has primary input D-alanine zwitterion
-relationship: BFO:0000050 GO:0042941 ! part of D-alanine transmembrane transport
-relationship: RO:0004009 CHEBI:57416 ! has primary input D-alanine zwitterion
-
[Term]
id: GO:0042945
name: D-serine transmembrane transporter activity
@@ -88145,7 +87502,6 @@ id: GO:0042983
name: amyloid precursor protein biosynthetic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0042982 ! amyloid precursor protein metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 PR:000004168 ! has primary output amyloid-beta precursor protein
relationship: RO:0004008 PR:000004168 ! has primary output amyloid-beta precursor protein
@@ -88618,8 +87974,8 @@ relationship: RO:0004009 CHEBI:35238 ! has primary input amino acid zwitterion
[Term]
id: GO:0043201
name: response to L-leucine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:57427 ! has primary input L-leucine zwitterion
@@ -88878,7 +88234,7 @@ relationship: RO:0004009 CHEBI:58097 ! has primary input morphine(1+)
[Term]
id: GO:0043279
name: response to alkaloid
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:22315 ! has primary input alkaloid
relationship: RO:0004009 CHEBI:22315 ! has primary input alkaloid
@@ -89553,7 +88909,6 @@ name: urea catabolic process
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043605 ! amide catabolic process
is_a: GO:0044282 ! small molecule catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:16199 ! has primary input urea
relationship: RO:0004009 CHEBI:16199 ! has primary input urea
@@ -89579,7 +88934,7 @@ relationship: RO:0002212 GO:0003700 ! negatively regulates DNA-binding transcrip
id: GO:0043434
name: response to peptide hormone
is_a: GO:0009725 ! response to hormone
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:25905 ! has primary input peptide hormone
@@ -89931,7 +89286,7 @@ relationship: RO:0002629 GO:0004674 ! directly positively regulates protein seri
[Term]
id: GO:0043542
name: endothelial cell migration
-is_a: GO:0010631 ! epithelial cell migration
+is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: RO:0002565 CL:0000115 ! results in movement of endothelial cell
relationship: RO:0002565 CL:0000115 ! results in movement of endothelial cell
@@ -90194,7 +89549,7 @@ relationship: RO:0004009 CHEBI:64558 ! has primary input methionine zwitterion
[Term]
id: GO:0043891
-name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
+name: glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -90535,7 +89890,7 @@ relationship: RO:0002339 GO:0005856 ! has target end location cytoskeleton
[Term]
id: GO:0044381
name: glucose import in response to insulin stimulus
-is_a: GO:0046323 ! glucose import
+is_a: GO:0046323 ! D-glucose import
relationship: BFO:0000050 GO:0032869 ! part of cellular response to insulin stimulus
[Term]
@@ -91342,17 +90697,10 @@ id: GO:0045259
name: proton-transporting ATP synthase complex
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:0034703 ! cation channel complex
+is_a: GO:0098803 ! respiratory chain complex
is_a: GO:1902494 ! catalytic complex
relationship: RO:0002215 GO:0046933 ! capable of proton-transporting ATP synthase activity, rotational mechanism
-[Term]
-id: GO:0045260
-name: plasma membrane proton-transporting ATP synthase complex
-is_a: GO:0045259 ! proton-transporting ATP synthase complex
-is_a: GO:0098797 ! plasma membrane protein complex
-intersection_of: GO:0045259 ! proton-transporting ATP synthase complex
-intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane
-
[Term]
id: GO:0045296
name: cadherin binding
@@ -91370,14 +90718,6 @@ intersection_of: RO:0002299 UBERON:0002280 ! results in maturation of otolith
relationship: BFO:0000050 GO:0048840 ! part of otolith development
relationship: RO:0002299 UBERON:0002280 ! results in maturation of otolith
-[Term]
-id: GO:0045320
-name: chloroplast proton-transporting ATP synthase complex
-is_a: GO:0045259 ! proton-transporting ATP synthase complex
-is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex
-intersection_of: GO:0045259 ! proton-transporting ATP synthase complex
-intersection_of: BFO:0000050 GO:0009507 ! part of chloroplast
-
[Term]
id: GO:0045321
name: leukocyte activation
@@ -93911,8 +93251,8 @@ relationship: RO:0004008 CHEBI:15318 ! has primary output xanthine
[Term]
id: GO:0046112
name: nucleobase biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0009112 ! nucleobase metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18282 ! has primary output nucleobase
relationship: RO:0004008 CHEBI:18282 ! has primary output nucleobase
@@ -93920,8 +93260,8 @@ relationship: RO:0004008 CHEBI:18282 ! has primary output nucleobase
[Term]
id: GO:0046113
name: nucleobase catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0009112 ! nucleobase metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:18282 ! has primary input nucleobase
relationship: RO:0004009 CHEBI:18282 ! has primary input nucleobase
@@ -94425,34 +93765,34 @@ relationship: RO:0002212 GO:0019395 ! negatively regulates fatty acid oxidation
[Term]
id: GO:0046323
-name: glucose import
-is_a: GO:1904659 ! glucose transmembrane transport
+name: D-glucose import
+is_a: GO:1904659 ! D-glucose transmembrane transport
[Term]
id: GO:0046324
-name: regulation of glucose import
-is_a: GO:0010827 ! regulation of glucose transmembrane transport
+name: regulation of D-glucose import
+is_a: GO:0010827 ! regulation of D-glucose transmembrane transport
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0046323 ! regulates glucose import
-relationship: RO:0002211 GO:0046323 ! regulates glucose import
+intersection_of: RO:0002211 GO:0046323 ! regulates D-glucose import
+relationship: RO:0002211 GO:0046323 ! regulates D-glucose import
[Term]
id: GO:0046325
-name: negative regulation of glucose import
-is_a: GO:0010829 ! negative regulation of glucose transmembrane transport
-is_a: GO:0046324 ! regulation of glucose import
+name: negative regulation of D-glucose import
+is_a: GO:0010829 ! negative regulation of D-glucose transmembrane transport
+is_a: GO:0046324 ! regulation of D-glucose import
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0046323 ! negatively regulates glucose import
-relationship: RO:0002212 GO:0046323 ! negatively regulates glucose import
+intersection_of: RO:0002212 GO:0046323 ! negatively regulates D-glucose import
+relationship: RO:0002212 GO:0046323 ! negatively regulates D-glucose import
[Term]
id: GO:0046326
-name: positive regulation of glucose import
-is_a: GO:0010828 ! positive regulation of glucose transmembrane transport
-is_a: GO:0046324 ! regulation of glucose import
+name: positive regulation of D-glucose import
+is_a: GO:0010828 ! positive regulation of D-glucose transmembrane transport
+is_a: GO:0046324 ! regulation of D-glucose import
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0046323 ! positively regulates glucose import
-relationship: RO:0002213 GO:0046323 ! positively regulates glucose import
+intersection_of: RO:0002213 GO:0046323 ! positively regulates D-glucose import
+relationship: RO:0002213 GO:0046323 ! positively regulates D-glucose import
[Term]
id: GO:0046327
@@ -94561,10 +93901,9 @@ relationship: RO:0004009 CHEBI:36233 ! has primary input disaccharide
id: GO:0046356
name: acetyl-CoA catabolic process
is_a: GO:0006084 ! acetyl-CoA metabolic process
-is_a: GO:0009154 ! purine ribonucleotide catabolic process
-is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
-is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
+is_a: GO:0072523 ! purine-containing compound catabolic process
+is_a: GO:1901292 ! nucleoside phosphate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:57288 ! has primary input acetyl-CoA(4-)
relationship: RO:0004009 CHEBI:57288 ! has primary input acetyl-CoA(4-)
@@ -94680,15 +94019,6 @@ intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:25710 ! has primary input organophosphorus compound
relationship: RO:0004009 CHEBI:25710 ! has primary input organophosphorus compound
-[Term]
-id: GO:0046436
-name: D-alanine metabolic process
-is_a: GO:0006522 ! alanine metabolic process
-is_a: GO:0046416 ! D-amino acid metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:57416 ! has primary input or output D-alanine zwitterion
-relationship: RO:0004007 CHEBI:57416 ! has primary input or output D-alanine zwitterion
-
[Term]
id: GO:0046437
name: D-amino acid biosynthetic process
@@ -94845,7 +94175,6 @@ is_a: GO:0044249 ! cellular biosynthetic process
id: GO:0046470
name: phosphatidylcholine metabolic process
is_a: GO:0006650 ! glycerophospholipid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:64482 ! has primary input or output phosphatidylcholine
relationship: RO:0004007 CHEBI:64482 ! has primary input or output phosphatidylcholine
@@ -95571,8 +94900,8 @@ relationship: RO:0002212 GO:0030073 ! negatively regulates insulin secretion
[Term]
id: GO:0046681
name: response to carbamate
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0017085 ! response to insecticide
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:13941 ! has primary input carbamate
@@ -98908,7 +98237,7 @@ relationship: RO:0002211 GO:0050432 ! regulates catecholamine secretion
[Term]
id: GO:0050482
-name: arachidonic acid secretion
+name: arachidonate secretion
comment: This term should be used to annotate release of arachidonic acid from the cell. For the hydrolytic release of arachidonic acid from a phospholipid, consider instead annotating to 'phospholipase A2 activity ; GO:0004623'.
is_a: GO:0032309 ! icosanoid secretion
is_a: GO:1903963 ! arachidonate transport
@@ -98933,7 +98262,7 @@ relationship: RO:0004009 CHEBI:62920 ! has primary input icosatetraenoate
[Term]
id: GO:0050544
-name: arachidonic acid binding
+name: arachidonate binding
is_a: GO:0050542 ! icosanoid binding
is_a: GO:0050543 ! icosatetraenoic acid binding
intersection_of: GO:0005488 ! binding
@@ -99574,10 +98903,11 @@ relationship: RO:0002211 GO:0006694 ! regulates steroid biosynthetic process
id: GO:0050812
name: regulation of acyl-CoA biosynthetic process
is_a: GO:0019217 ! regulation of fatty acid metabolic process
+is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
+is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0071616 ! regulates acyl-CoA biosynthetic process
relationship: RO:0002211 GO:0071616 ! regulates acyl-CoA biosynthetic process
@@ -99875,7 +99205,7 @@ is_a: GO:0008150 ! biological_process
[Term]
id: GO:0050898
name: nitrile metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:18379 ! has primary input or output nitrile
relationship: RO:0004007 CHEBI:18379 ! has primary input or output nitrile
@@ -99883,8 +99213,8 @@ relationship: RO:0004007 CHEBI:18379 ! has primary input or output nitrile
[Term]
id: GO:0050899
name: nitrile catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0050898 ! nitrile metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:18379 ! has primary input nitrile
relationship: RO:0004009 CHEBI:18379 ! has primary input nitrile
@@ -99931,7 +99261,6 @@ relationship: BFO:0000050 GO:0007606 ! part of sensory perception of chemical st
[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
-is_a: GO:0009584 ! detection of visible light
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: BFO:0000050 GO:0007601 ! part of visual perception
@@ -101955,9 +101284,9 @@ relationship: RO:0004009 CHEBI:29108 ! has primary input calcium(2+)
[Term]
id: GO:0051593
name: response to folic acid
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:62501 ! has primary input folate(2-)
@@ -103120,15 +102449,6 @@ intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:17408 ! has primary input monoacylglycerol
relationship: RO:0004009 CHEBI:17408 ! has primary input monoacylglycerol
-[Term]
-id: GO:0052655
-name: L-valine transaminase activity
-is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity
-relationship: RO:0000057 CHEBI:11851 ! has participant 3-methyl-2-oxobutanoate
-relationship: RO:0000057 CHEBI:16810 ! has participant 2-oxoglutarate(2-)
-relationship: RO:0000057 CHEBI:29985 ! has participant L-glutamate(1-)
-relationship: RO:0000057 CHEBI:57762 ! has participant L-valine zwitterion
-
[Term]
id: GO:0052689
name: carboxylic ester hydrolase activity
@@ -103137,7 +102457,7 @@ is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
[Term]
id: GO:0052803
name: imidazole-containing compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:24780 ! has primary input or output imidazoles
relationship: RO:0004007 CHEBI:24780 ! has primary input or output imidazoles
@@ -103145,8 +102465,8 @@ relationship: RO:0004007 CHEBI:24780 ! has primary input or output imidazoles
[Term]
id: GO:0052805
name: imidazole-containing compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:24780 ! has primary input imidazoles
relationship: RO:0004009 CHEBI:24780 ! has primary input imidazoles
@@ -103328,22 +102648,13 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development
relationship: RO:0002212 GO:0048738 ! negatively regulates cardiac muscle tissue development
-[Term]
-id: GO:0055035
-name: plastid thylakoid membrane
-is_a: GO:0042170 ! plastid membrane
-is_a: GO:0042651 ! thylakoid membrane
-intersection_of: GO:0016020 ! membrane
-intersection_of: BFO:0000050 GO:0031976 ! part of plastid thylakoid
-relationship: BFO:0000050 GO:0031976 ! part of plastid thylakoid
-
[Term]
id: GO:0055056
name: D-glucose transmembrane transporter activity
is_a: GO:0015149 ! hexose transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
-intersection_of: RO:0004009 CHEBI:17634 ! has primary input D-glucose
-relationship: RO:0004009 CHEBI:17634 ! has primary input D-glucose
+intersection_of: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose
+relationship: RO:0004009 CHEBI:4167 ! has primary input D-glucopyranose
[Term]
id: GO:0055057
@@ -103499,7 +102810,7 @@ relationship: RO:0002332 CHEBI:15889 ! regulates levels of sterol
id: GO:0055094
name: response to lipoprotein particle
is_a: GO:0009719 ! response to endogenous stimulus
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:6495 ! has primary input lipoprotein
relationship: RO:0004009 CHEBI:6495 ! has primary input lipoprotein
@@ -103611,16 +102922,6 @@ intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:60039 ! has primary output L-proline zwitterion
relationship: RO:0004008 CHEBI:60039 ! has primary output L-proline zwitterion
-[Term]
-id: GO:0055130
-name: D-alanine catabolic process
-is_a: GO:0006524 ! alanine catabolic process
-is_a: GO:0019478 ! D-amino acid catabolic process
-is_a: GO:0046436 ! D-alanine metabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:57416 ! has primary input D-alanine zwitterion
-relationship: RO:0004009 CHEBI:57416 ! has primary input D-alanine zwitterion
-
[Term]
id: GO:0060004
name: reflex
@@ -109490,8 +108791,8 @@ id: GO:0061365
name: positive regulation of triglyceride lipase activity
is_a: GO:0060193 ! positive regulation of lipase activity
intersection_of: GO:0065009 ! regulation of molecular function
-intersection_of: RO:0002213 GO:0004806 ! positively regulates triglyceride lipase activity
-relationship: RO:0002213 GO:0004806 ! positively regulates triglyceride lipase activity
+intersection_of: RO:0002213 GO:0004806 ! positively regulates triacylglycerol lipase activity
+relationship: RO:0002213 GO:0004806 ! positively regulates triacylglycerol lipase activity
[Term]
id: GO:0061370
@@ -109604,7 +108905,7 @@ id: GO:0061431
name: cellular response to methionine
is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904640 ! response to methionine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -109856,17 +109157,6 @@ intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:59905 ! has primary input dopaminium(1+)
relationship: BFO:0000050 GO:0001963 ! part of synaptic transmission, dopaminergic
-[Term]
-id: GO:0061528
-name: aspartate secretion
-is_a: GO:0015740 ! C4-dicarboxylate transport
-is_a: GO:0015800 ! acidic amino acid transport
-is_a: GO:0032940 ! secretion by cell
-is_a: GO:0071705 ! nitrogen compound transport
-intersection_of: GO:0046903 ! secretion
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-relationship: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-
[Term]
id: GO:0061529
name: epinephrine secretion, neurotransmission
@@ -109876,14 +109166,6 @@ intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: RO:0004009 CHEBI:33568 ! has primary input adrenaline
relationship: RO:0004009 CHEBI:33568 ! has primary input adrenaline
-[Term]
-id: GO:0061530
-name: aspartate secretion, neurotransmission
-is_a: GO:0007269 ! neurotransmitter secretion
-is_a: GO:0061528 ! aspartate secretion
-intersection_of: GO:0007269 ! neurotransmitter secretion
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-
[Term]
id: GO:0061531
name: primary amine secretion
@@ -110535,7 +109817,7 @@ intersection_of: RO:0002339 GO:0005886 ! has target end location plasma membrane
[Term]
id: GO:0061959
name: response to (R)-carnitine
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:16347 ! has primary input (R)-carnitine
relationship: RO:0004009 CHEBI:16347 ! has primary input (R)-carnitine
@@ -110662,7 +109944,6 @@ id: GO:0062112
name: fatty acid primary amide biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0062126 ! fatty acid primary amide metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901570 ! fatty acid derivative biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:143129 ! has primary output primary fatty amide
@@ -110680,7 +109961,6 @@ relationship: RO:0002211 GO:0140053 ! regulates mitochondrial gene expression
id: GO:0062126
name: fatty acid primary amide metabolic process
is_a: GO:0043603 ! amide metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:143129 ! has primary input or output primary fatty amide
@@ -110690,7 +109970,6 @@ relationship: RO:0004007 CHEBI:143129 ! has primary input or output primary fatt
id: GO:0062127
name: fatty acid primary amide catabolic process
is_a: GO:0062126 ! fatty acid primary amide metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:143129 ! has primary input primary fatty amide
@@ -111783,15 +111062,6 @@ intersection_of: GO:0048878 ! chemical homeostasis
intersection_of: RO:0002332 CHEBI:17855 ! regulates levels of triglyceride
relationship: RO:0002332 CHEBI:17855 ! regulates levels of triglyceride
-[Term]
-id: GO:0070335
-name: aspartate binding
-is_a: GO:0016597 ! amino acid binding
-is_a: GO:0031406 ! carboxylic acid binding
-intersection_of: GO:0005488 ! binding
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-relationship: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-
[Term]
id: GO:0070341
name: fat cell proliferation
@@ -112100,21 +111370,6 @@ id: GO:0070460
name: thyroid-stimulating hormone secretion
is_a: GO:0030072 ! peptide hormone secretion
-[Term]
-id: GO:0070469
-name: respirasome
-is_a: GO:0098796 ! membrane protein complex
-
-[Term]
-id: GO:0070470
-name: plasma membrane respirasome
-is_a: GO:0070469 ! respirasome
-is_a: GO:0098797 ! plasma membrane protein complex
-intersection_of: GO:0070469 ! respirasome
-intersection_of: BFO:0000050 GO:0005886 ! part of plasma membrane
-relationship: RO:0002160 NCBITaxon:2 ! only in taxon Bacteria
-relationship: RO:0002162 NCBITaxon:2 {all_only="true"} ! in taxon Bacteria
-
[Term]
id: GO:0070482
name: response to oxygen levels
@@ -112209,11 +111464,6 @@ intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:30245 ! has primary input linoleate
relationship: RO:0004009 CHEBI:30245 ! has primary input linoleate
-[Term]
-id: GO:0070547
-name: L-tyrosine aminotransferase activity
-is_a: GO:0008483 ! transaminase activity
-
[Term]
id: GO:0070553
name: nicotinic acid receptor activity
@@ -112750,34 +112000,11 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0008654 ! positively regulates phospholipid biosynthetic process
relationship: RO:0002213 GO:0008654 ! positively regulates phospholipid biosynthetic process
-[Term]
-id: GO:0071077
-name: adenosine 3',5'-bisphosphate transmembrane transporter activity
-is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity
-is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity
-intersection_of: GO:0022857 ! transmembrane transporter activity
-intersection_of: RO:0004009 CHEBI:37240 ! has primary input adenosine 3',5'-bisphosphate
-relationship: BFO:0000050 GO:0071106 ! part of adenosine 3',5'-bisphosphate transmembrane transport
-relationship: RO:0004009 CHEBI:37240 ! has primary input adenosine 3',5'-bisphosphate
-
[Term]
id: GO:0071104
name: response to interleukin-9
is_a: GO:0034097 ! response to cytokine
-[Term]
-id: GO:0071106
-name: adenosine 3',5'-bisphosphate transmembrane transport
-comment: Note that this term is not intended for use in annotating lateral movement within membranes.
-is_a: GO:0015868 ! purine ribonucleotide transport
-is_a: GO:0051503 ! adenine nucleotide transport
-is_a: GO:0072530 ! purine-containing compound transmembrane transport
-is_a: GO:1901679 ! nucleotide transmembrane transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
-intersection_of: RO:0004009 CHEBI:37240 ! has primary input adenosine 3',5'-bisphosphate
-relationship: RO:0004009 CHEBI:37240 ! has primary input adenosine 3',5'-bisphosphate
-
[Term]
id: GO:0071109
name: superior temporal gyrus development
@@ -112875,7 +112102,7 @@ name: cellular response to folic acid
is_a: GO:0051593 ! response to folic acid
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:62501 ! has primary input folate(2-)
@@ -112885,8 +112112,8 @@ id: GO:0071232
name: cellular response to histidine
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0080052 ! response to histidine
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:27570 ! has primary input histidine
@@ -112896,7 +112123,7 @@ id: GO:0071233
name: cellular response to L-leucine
is_a: GO:0043201 ! response to L-leucine
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:57427 ! has primary input L-leucine zwitterion
@@ -112906,8 +112133,8 @@ id: GO:0071234
name: cellular response to phenylalanine
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0080053 ! response to phenylalanine
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:28044 ! has primary input phenylalanine
@@ -112918,7 +112145,7 @@ name: cellular response to proline
is_a: GO:0010238 ! response to proline
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:26271 ! has primary input proline
@@ -113047,7 +112274,7 @@ name: cellular response to cobalamin
is_a: GO:0033590 ! response to cobalamin
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:30411 ! has primary input cobalamin
@@ -113077,8 +112304,8 @@ name: cellular response to vitamin B1
is_a: GO:0010266 ! response to vitamin B1
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
+is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:18385 ! has primary input thiamine(1+)
@@ -113124,7 +112351,7 @@ intersection_of: RO:0004009 CHEBI:30089 ! has primary input acetate
id: GO:0071312
name: cellular response to alkaloid
is_a: GO:0043279 ! response to alkaloid
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:22315 ! has primary input alkaloid
@@ -113168,7 +112395,7 @@ id: GO:0071318
name: cellular response to ATP
is_a: GO:0033198 ! response to ATP
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:30616 ! has primary input ATP(4-)
@@ -113293,7 +112520,7 @@ id: GO:0071375
name: cellular response to peptide hormone stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043434 ! response to peptide hormone
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:25905 ! has primary input peptide hormone
@@ -113496,25 +112723,16 @@ id: GO:0071414
name: cellular response to methotrexate
is_a: GO:0031427 ! response to methotrexate
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:50681 ! has primary input methotrexate(2-)
-[Term]
-id: GO:0071417
-name: cellular response to organonitrogen compound
-is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0071495 ! cellular response to endogenous stimulus
-is_a: GO:1901699 ! cellular response to nitrogen compound
-intersection_of: GO:0070887 ! cellular response to chemical stimulus
-intersection_of: RO:0004009 CHEBI:35352 ! has primary input organonitrogen compound
-
[Term]
id: GO:0071418
name: cellular response to amine stimulus
is_a: GO:0014075 ! response to amine
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:32952 ! has primary input amine
@@ -113523,7 +112741,7 @@ id: GO:0071420
name: cellular response to histamine
is_a: GO:0034776 ! response to histamine
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:58432 ! has primary input histaminium
@@ -113620,7 +112838,7 @@ is_a: GO:0009719 ! response to endogenous stimulus
[Term]
id: GO:0071503
name: response to heparin
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:28304 ! has primary input heparin
@@ -113629,8 +112847,8 @@ relationship: RO:0004009 CHEBI:28304 ! has primary input heparin
[Term]
id: GO:0071504
name: cellular response to heparin
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071503 ! response to heparin
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:28304 ! has primary input heparin
@@ -113729,11 +112947,10 @@ relationship: RO:0002298 UBERON:0003051 ! results in morphogenesis of ear vesicl
id: GO:0071616
name: acyl-CoA biosynthetic process
is_a: GO:0006637 ! acyl-CoA metabolic process
-is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
-is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
-is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
is_a: GO:0035384 ! thioester biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
+is_a: GO:0072522 ! purine-containing compound biosynthetic process
+is_a: GO:1901293 ! nucleoside phosphate biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:58342 ! has primary output acyl-CoA(4-)
relationship: RO:0004008 CHEBI:58342 ! has primary output acyl-CoA(4-)
@@ -114279,7 +113496,7 @@ is_a: GO:0001664 ! G protein-coupled receptor binding
[Term]
id: GO:0071867
name: response to monoamine
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:63534 ! has primary input monoamine
relationship: RO:0004009 CHEBI:63534 ! has primary input monoamine
@@ -114287,8 +113504,8 @@ relationship: RO:0004009 CHEBI:63534 ! has primary input monoamine
[Term]
id: GO:0071868
name: cellular response to monoamine stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071867 ! response to monoamine
+is_a: GO:1901699 ! cellular response to nitrogen compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:63534 ! has primary input monoamine
@@ -116295,7 +115512,6 @@ id: GO:0072338
name: lactam metabolic process
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:24995 ! has primary input or output lactam
relationship: RO:0004007 CHEBI:24995 ! has primary input or output lactam
@@ -116305,7 +115521,6 @@ id: GO:0072339
name: lactam biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0072338 ! lactam metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:24995 ! has primary output lactam
relationship: RO:0004008 CHEBI:24995 ! has primary output lactam
@@ -116313,8 +115528,8 @@ relationship: RO:0004008 CHEBI:24995 ! has primary output lactam
[Term]
id: GO:0072340
name: lactam catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0072338 ! lactam metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:24995 ! has primary input lactam
relationship: RO:0004009 CHEBI:24995 ! has primary input lactam
@@ -116456,7 +115671,7 @@ relationship: RO:0002296 UBERON:0001343 ! results in development of seminiferous
[Term]
id: GO:0072521
name: purine-containing compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26401 ! has primary input or output purines
relationship: RO:0004007 CHEBI:26401 ! has primary input or output purines
@@ -116464,8 +115679,8 @@ relationship: RO:0004007 CHEBI:26401 ! has primary input or output purines
[Term]
id: GO:0072522
name: purine-containing compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072521 ! purine-containing compound metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26401 ! has primary output purines
relationship: RO:0004008 CHEBI:26401 ! has primary output purines
@@ -116473,8 +115688,8 @@ relationship: RO:0004008 CHEBI:26401 ! has primary output purines
[Term]
id: GO:0072523
name: purine-containing compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0072521 ! purine-containing compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:26401 ! has primary input purines
relationship: RO:0004009 CHEBI:26401 ! has primary input purines
@@ -116482,7 +115697,7 @@ relationship: RO:0004009 CHEBI:26401 ! has primary input purines
[Term]
id: GO:0072524
name: pyridine-containing compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:26421 ! has primary input or output pyridines
relationship: RO:0004007 CHEBI:26421 ! has primary input or output pyridines
@@ -116490,8 +115705,8 @@ relationship: RO:0004007 CHEBI:26421 ! has primary input or output pyridines
[Term]
id: GO:0072525
name: pyridine-containing compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:26421 ! has primary output pyridines
relationship: RO:0004008 CHEBI:26421 ! has primary output pyridines
@@ -116499,8 +115714,8 @@ relationship: RO:0004008 CHEBI:26421 ! has primary output pyridines
[Term]
id: GO:0072526
name: pyridine-containing compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:26421 ! has primary input pyridines
relationship: RO:0004009 CHEBI:26421 ! has primary input pyridines
@@ -116508,7 +115723,7 @@ relationship: RO:0004009 CHEBI:26421 ! has primary input pyridines
[Term]
id: GO:0072527
name: pyrimidine-containing compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:39447 ! has primary input or output pyrimidines
relationship: RO:0004007 CHEBI:39447 ! has primary input or output pyrimidines
@@ -116516,8 +115731,8 @@ relationship: RO:0004007 CHEBI:39447 ! has primary input or output pyrimidines
[Term]
id: GO:0072528
name: pyrimidine-containing compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:39447 ! has primary output pyrimidines
relationship: RO:0004008 CHEBI:39447 ! has primary output pyrimidines
@@ -116525,8 +115740,8 @@ relationship: RO:0004008 CHEBI:39447 ! has primary output pyrimidines
[Term]
id: GO:0072529
name: pyrimidine-containing compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:39447 ! has primary input pyrimidines
relationship: RO:0004009 CHEBI:39447 ! has primary input pyrimidines
@@ -116642,7 +115857,7 @@ relationship: RO:0002298 UBERON:0002107 ! results in morphogenesis of liver
[Term]
id: GO:0072577
name: endothelial cell apoptotic process
-is_a: GO:1904019 ! epithelial cell apoptotic process
+is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: BFO:0000066 CL:0000115 ! occurs in endothelial cell
relationship: BFO:0000066 CL:0000115 ! occurs in endothelial cell
@@ -116912,8 +116127,8 @@ intersection_of: RO:0004009 CHEBI:27899 ! has primary input cisplatin
id: GO:0072748
name: cellular response to tacrolimus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901327 ! response to tacrolimus
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:61049 ! has primary input tacrolimus (anhydrous)
@@ -116921,8 +116136,8 @@ intersection_of: RO:0004009 CHEBI:61049 ! has primary input tacrolimus (anhydrou
[Term]
id: GO:0072753
name: cellular response to glutathione
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901370 ! response to glutathione
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:57925 ! has primary input glutathionate(1-)
@@ -116976,7 +116191,12 @@ relationship: RO:0002212 GO:0075009 ! negatively regulates germ tube formation
[Term]
id: GO:0080020
name: regulation of coenzyme A biosynthetic process
-is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
+is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
+is_a: GO:0019220 ! regulation of phosphate metabolic process
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
+is_a: GO:0034248 ! regulation of amide metabolic process
+is_a: GO:0042762 ! regulation of sulfur metabolic process
+is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015937 ! regulates coenzyme A biosynthetic process
relationship: RO:0002211 GO:0015937 ! regulates coenzyme A biosynthetic process
@@ -117004,8 +116224,8 @@ relationship: RO:0004007 CHEBI:143274 ! has primary input or output indole-3-but
id: GO:0080026
name: response to indolebutyric acid
is_a: GO:0009733 ! response to auxin
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:143274 ! has primary input indole-3-butyrate
@@ -117014,8 +116234,8 @@ relationship: RO:0004009 CHEBI:143274 ! has primary input indole-3-butyrate
[Term]
id: GO:0080028
name: nitrile biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0050898 ! nitrile metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:18379 ! has primary output nitrile
relationship: RO:0004008 CHEBI:18379 ! has primary output nitrile
@@ -117041,9 +116261,9 @@ relationship: RO:0002211 GO:0048316 ! regulates seed development
[Term]
id: GO:0080052
name: response to histidine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:27570 ! has primary input histidine
@@ -117052,9 +116272,9 @@ relationship: RO:0004009 CHEBI:27570 ! has primary input histidine
[Term]
id: GO:0080053
name: response to phenylalanine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:28044 ! has primary input phenylalanine
@@ -118465,20 +117685,20 @@ relationship: RO:0002212 GO:0031577 ! negatively regulates spindle checkpoint si
[Term]
id: GO:0090237
-name: regulation of arachidonic acid secretion
+name: regulation of arachidonate secretion
is_a: GO:0032303 ! regulation of icosanoid secretion
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0050482 ! regulates arachidonic acid secretion
-relationship: RO:0002211 GO:0050482 ! regulates arachidonic acid secretion
+intersection_of: RO:0002211 GO:0050482 ! regulates arachidonate secretion
+relationship: RO:0002211 GO:0050482 ! regulates arachidonate secretion
[Term]
id: GO:0090238
-name: positive regulation of arachidonic acid secretion
+name: positive regulation of arachidonate secretion
is_a: GO:0032305 ! positive regulation of icosanoid secretion
-is_a: GO:0090237 ! regulation of arachidonic acid secretion
+is_a: GO:0090237 ! regulation of arachidonate secretion
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0050482 ! positively regulates arachidonic acid secretion
-relationship: RO:0002213 GO:0050482 ! positively regulates arachidonic acid secretion
+intersection_of: RO:0002213 GO:0050482 ! positively regulates arachidonate secretion
+relationship: RO:0002213 GO:0050482 ! positively regulates arachidonate secretion
[Term]
id: GO:0090252
@@ -119071,20 +118291,6 @@ intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:49713 ! has primary input lithium(1+)
-[Term]
-id: GO:0090453
-name: aspartate transmembrane import into vacuole
-is_a: GO:0015810 ! aspartate transmembrane transport
-is_a: GO:0034486 ! vacuolar transmembrane transport
-is_a: GO:0034487 ! vacuolar amino acid transmembrane transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
-intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
-intersection_of: RO:0002342 GO:0005774 ! results in transport across vacuolar membrane
-intersection_of: RO:0004009 CHEBI:35391 ! has primary input aspartate(1-)
-relationship: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
-relationship: RO:0002339 GO:0005829 ! has target end location cytosol
-
[Term]
id: GO:0090454
name: glutamate transmembrane import into vacuole
@@ -119115,14 +118321,6 @@ intersection_of: RO:0004009 CHEBI:46912 ! has primary input ornithinium(1+)
relationship: RO:0002338 GO:0005829 ! has target start location cytosol
relationship: RO:0002339 GO:0005773 ! has target end location vacuole
-[Term]
-id: GO:0090459
-name: intracellular aspartate homeostasis
-is_a: GO:0080144 ! intracellular amino acid homeostasis
-intersection_of: GO:0019725 ! cellular homeostasis
-intersection_of: RO:0002332 CHEBI:35391 ! regulates levels of aspartate(1-)
-relationship: RO:0002332 CHEBI:35391 ! regulates levels of aspartate(1-)
-
[Term]
id: GO:0090460
name: intracellular threonine homeostasis
@@ -119982,8 +119180,10 @@ name: mitochondrial respirasome assembly
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0065003 ! protein-containing complex assembly
intersection_of: GO:0022607 ! cellular component assembly
-intersection_of: RO:0002588 GO:0005746 ! results in assembly of mitochondrial respirasome
-relationship: RO:0002588 GO:0005746 ! results in assembly of mitochondrial respirasome
+intersection_of: BFO:0000066 GO:0005739 ! occurs in mitochondrion
+intersection_of: RO:0002588 GO:0098803 ! results in assembly of respiratory chain complex
+relationship: BFO:0000066 GO:0005739 ! occurs in mitochondrion
+relationship: RO:0002588 GO:0098803 ! results in assembly of respiratory chain complex
[Term]
id: GO:0097252
@@ -120084,8 +119284,8 @@ relationship: RO:0004009 CHEBI:31355 ! has primary input carboplatin
[Term]
id: GO:0097330
name: response to 5-fluoro-2'-deoxyuridine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:60761 ! has primary input floxuridine
@@ -120094,8 +119294,8 @@ relationship: RO:0004009 CHEBI:60761 ! has primary input floxuridine
[Term]
id: GO:0097331
name: response to cytarabine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1903416 ! response to glycoside
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:28680 ! has primary input cytarabine
@@ -120104,8 +119304,8 @@ relationship: RO:0004009 CHEBI:28680 ! has primary input cytarabine
[Term]
id: GO:0097333
name: response to olanzapine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:7735 ! has primary input olanzapine
relationship: RO:0004009 CHEBI:7735 ! has primary input olanzapine
@@ -120113,9 +119313,9 @@ relationship: RO:0004009 CHEBI:7735 ! has primary input olanzapine
[Term]
id: GO:0097334
name: response to perphenazine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:8028 ! has primary input perphenazine
relationship: RO:0004009 CHEBI:8028 ! has primary input perphenazine
@@ -120123,8 +119323,8 @@ relationship: RO:0004009 CHEBI:8028 ! has primary input perphenazine
[Term]
id: GO:0097335
name: response to quetiapine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:8707 ! has primary input quetiapine
relationship: RO:0004009 CHEBI:8707 ! has primary input quetiapine
@@ -120132,8 +119332,8 @@ relationship: RO:0004009 CHEBI:8707 ! has primary input quetiapine
[Term]
id: GO:0097336
name: response to risperidone
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:8871 ! has primary input risperidone
@@ -120142,8 +119342,8 @@ relationship: RO:0004009 CHEBI:8871 ! has primary input risperidone
[Term]
id: GO:0097337
name: response to ziprasidone
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:10119 ! has primary input ziprasidone
relationship: RO:0004009 CHEBI:10119 ! has primary input ziprasidone
@@ -120151,8 +119351,8 @@ relationship: RO:0004009 CHEBI:10119 ! has primary input ziprasidone
[Term]
id: GO:0097338
name: response to clozapine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:3766 ! has primary input clozapine
relationship: RO:0004009 CHEBI:3766 ! has primary input clozapine
@@ -120445,7 +119645,7 @@ relationship: BFO:0000051 GO:1990720 ! has part C2 axonemal microtubule
[Term]
id: GO:0097545
-name: axonemal outer doublet
+name: axonemal doublet microtubule
is_a: GO:0110165 ! cellular anatomical entity
relationship: BFO:0000050 GO:0005930 ! part of axoneme
relationship: BFO:0000051 GO:0097649 ! has part A axonemal microtubule
@@ -120575,13 +119775,13 @@ is_a: GO:0098802 ! plasma membrane signaling receptor complex
id: GO:0097649
name: A axonemal microtubule
is_a: GO:0005879 ! axonemal microtubule
-relationship: BFO:0000050 GO:0097545 ! part of axonemal outer doublet
+relationship: BFO:0000050 GO:0097545 ! part of axonemal doublet microtubule
[Term]
id: GO:0097650
name: B axonemal microtubule
is_a: GO:0005879 ! axonemal microtubule
-relationship: BFO:0000050 GO:0097545 ! part of axonemal outer doublet
+relationship: BFO:0000050 GO:0097545 ! part of axonemal doublet microtubule
[Term]
id: GO:0097683
@@ -120677,7 +119877,7 @@ relationship: BFO:0000051 GO:0001534 ! has part radial spoke
relationship: BFO:0000051 GO:0036156 ! has part inner dynein arm
relationship: BFO:0000051 GO:0036157 ! has part outer dynein arm
relationship: BFO:0000051 GO:0097540 ! has part axonemal central pair
-relationship: BFO:0000051 GO:0097545 ! has part axonemal outer doublet
+relationship: BFO:0000051 GO:0097545 ! has part axonemal doublet microtubule
[Term]
id: GO:0097730
@@ -121145,9 +120345,9 @@ intersection_of: RO:0004009 CHEBI:16646 ! has primary input carbohydrate
[Term]
id: GO:0098708
-name: glucose import across plasma membrane
+name: D-glucose import across plasma membrane
is_a: GO:0140271 ! hexose import across plasma membrane
-is_a: GO:1904659 ! glucose transmembrane transport
+is_a: GO:1904659 ! D-glucose transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
@@ -121524,10 +120724,7 @@ intersection_of: RO:0002215 GO:0038023 ! capable of signaling receptor activity
[Term]
id: GO:0098803
name: respiratory chain complex
-is_a: GO:0098796 ! membrane protein complex
-intersection_of: GO:0032991 ! protein-containing complex
-intersection_of: BFO:0000050 GO:0070469 ! part of respirasome
-relationship: BFO:0000050 GO:0070469 ! part of respirasome
+is_a: GO:0032991 ! protein-containing complex
[Term]
id: GO:0098804
@@ -121538,14 +120735,6 @@ intersection_of: RO:0002007 GO:0097730 ! bounding layer of non-motile cilium
relationship: BFO:0000050 GO:0097730 ! part of non-motile cilium
relationship: RO:0002007 GO:0097730 ! bounding layer of non-motile cilium
-[Term]
-id: GO:0098807
-name: chloroplast thylakoid membrane protein complex
-is_a: GO:0098796 ! membrane protein complex
-intersection_of: GO:0032991 ! protein-containing complex
-intersection_of: BFO:0000050 GO:0009535 ! part of chloroplast thylakoid membrane
-relationship: BFO:0000050 GO:0009535 ! part of chloroplast thylakoid membrane
-
[Term]
id: GO:0098813
name: nuclear chromosome segregation
@@ -124097,17 +123286,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0036444 ! negatively regulates calcium import into the mitochondrion
relationship: RO:0002212 GO:0036444 ! negatively regulates calcium import into the mitochondrion
-[Term]
-id: GO:0110101
-name: L-valine transmembrane import into vacuole
-is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole
-is_a: GO:1903785 ! L-valine transmembrane transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
-intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
-intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
-intersection_of: RO:0004009 CHEBI:57762 ! has primary input L-valine zwitterion
-
[Term]
id: GO:0110110
name: positive regulation of animal organ morphogenesis
@@ -124571,8 +123749,11 @@ relationship: RO:0002296 UBERON:0001737 ! results in development of larynx
[Term]
id: GO:0120225
name: coenzyme A binding
-is_a: GO:0032559 ! adenyl ribonucleotide binding
+is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
+is_a: GO:1901265 ! nucleoside phosphate binding
+is_a: GO:1901363 ! heterocyclic compound binding
+is_a: GO:1901681 ! sulfur compound binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
relationship: RO:0004009 CHEBI:57287 ! has primary input coenzyme A(4-)
@@ -124588,9 +123769,10 @@ relationship: RO:0004009 CHEBI:57292 ! has primary input succinyl-CoA(5-)
[Term]
id: GO:0120227
name: acyl-CoA binding
-is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
+is_a: GO:1901265 ! nucleoside phosphate binding
+is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding
intersection_of: GO:0005488 ! binding
intersection_of: RO:0004009 CHEBI:58342 ! has primary input acyl-CoA(4-)
@@ -124767,9 +123949,9 @@ id: GO:0120308
name: axonemal outer doublet assembly
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0009987 ! cellular process
-intersection_of: RO:0002588 GO:0097545 ! results in assembly of axonemal outer doublet
+intersection_of: RO:0002588 GO:0097545 ! results in assembly of axonemal doublet microtubule
relationship: BFO:0000050 GO:0035082 ! part of axoneme assembly
-relationship: RO:0002588 GO:0097545 ! results in assembly of axonemal outer doublet
+relationship: RO:0002588 GO:0097545 ! results in assembly of axonemal doublet microtubule
[Term]
id: GO:0120316
@@ -124800,6 +123982,16 @@ intersection_of: RO:0002297 UBERON:0003915 ! results in formation of endothelial
relationship: BFO:0000050 GO:0061154 ! part of endothelial tube morphogenesis
relationship: RO:0002297 UBERON:0003915 ! results in formation of endothelial tube
+[Term]
+id: GO:0120516
+name: diacylglycerol lipase activity
+is_a: GO:0016298 ! lipase activity
+relationship: RO:0000057 CHEBI:15377 ! has participant water
+relationship: RO:0000057 CHEBI:15378 ! has participant hydron
+relationship: RO:0000057 CHEBI:17408 ! has participant monoacylglycerol
+relationship: RO:0000057 CHEBI:18035 ! has participant diglyceride
+relationship: RO:0000057 CHEBI:28868 ! has participant fatty acid anion
+
[Term]
id: GO:0140013
name: meiotic nuclear division
@@ -125359,8 +124551,8 @@ id: GO:0140260
name: mitochondrial proton-transporting ATP synthase complex binding
is_a: GO:0044877 ! protein-containing complex binding
intersection_of: GO:0005488 ! binding
-intersection_of: RO:0004009 GO:0005753 ! has primary input mitochondrial proton-transporting ATP synthase complex
-relationship: RO:0004009 GO:0005753 ! has primary input mitochondrial proton-transporting ATP synthase complex
+intersection_of: RO:0004009 GO:0045259 ! has primary input proton-transporting ATP synthase complex
+relationship: RO:0004009 GO:0045259 ! has primary input proton-transporting ATP synthase complex
[Term]
id: GO:0140271
@@ -125464,17 +124656,6 @@ id: GO:0140375
name: immune receptor activity
is_a: GO:0038023 ! signaling receptor activity
-[Term]
-id: GO:0140406
-name: L-alanine export across the plasma membrane
-is_a: GO:0032973 ! amino acid export across plasma membrane
-is_a: GO:1904557 ! L-alanine transmembrane transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0002338 GO:0005829 ! has target start location cytosol
-intersection_of: RO:0002339 GO:0005576 ! has target end location extracellular region
-intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
-
[Term]
id: GO:0140420
name: heme import into cell
@@ -126019,15 +125200,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0003810 ! positively regulates protein-glutamine gamma-glutamyltransferase activity
relationship: RO:0002213 GO:0003810 ! positively regulates protein-glutamine gamma-glutamyltransferase activity
-[Term]
-id: GO:0150075
-name: negative regulation of protein-glutamine gamma-glutamyltransferase activity
-is_a: GO:0051348 ! negative regulation of transferase activity
-is_a: GO:0150073 ! regulation of protein-glutamine gamma-glutamyltransferase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0003810 ! negatively regulates protein-glutamine gamma-glutamyltransferase activity
-relationship: RO:0002212 GO:0003810 ! negatively regulates protein-glutamine gamma-glutamyltransferase activity
-
[Term]
id: GO:0150076
name: neuroinflammatory response
@@ -126435,6 +125607,23 @@ intersection_of: GO:0050892 ! intestinal absorption
intersection_of: RO:0004009 CHEBI:24875 ! has primary input iron cation
relationship: RO:0004009 CHEBI:24875 ! has primary input iron cation
+[Term]
+id: GO:0160192
+name: autophagosome-dependent secretion
+is_a: GO:0006887 ! exocytosis
+is_a: GO:0051656 ! establishment of organelle localization
+is_a: GO:0061906 ! autophagosome localization
+intersection_of: GO:0006887 ! exocytosis
+intersection_of: RO:0004009 GO:0005776 ! has primary input autophagosome
+
+[Term]
+id: GO:0160194
+name: stereocilium bundle organization
+is_a: GO:0016043 ! cellular component organization
+intersection_of: GO:0016043 ! cellular component organization
+intersection_of: RO:0002592 GO:0032421 ! results in organization of stereocilium bundle
+relationship: RO:0002592 GO:0032421 ! results in organization of stereocilium bundle
+
[Term]
id: GO:0170033
name: L-amino acid metabolic process
@@ -126488,7 +125677,6 @@ id: GO:0170038
name: proteinogenic amino acid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:83813 ! has primary output proteinogenic amino acid
relationship: RO:0004008 CHEBI:83813 ! has primary output proteinogenic amino acid
@@ -126498,7 +125686,6 @@ id: GO:0170039
name: proteinogenic amino acid metabolic process
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:83813 ! has primary input or output proteinogenic amino acid
relationship: RO:0004007 CHEBI:83813 ! has primary input or output proteinogenic amino acid
@@ -126508,7 +125695,6 @@ id: GO:0170040
name: proteinogenic amino acid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0170039 ! proteinogenic amino acid metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:83813 ! has primary input proteinogenic amino acid
relationship: RO:0004009 CHEBI:83813 ! has primary input proteinogenic amino acid
@@ -126518,7 +125704,6 @@ id: GO:0170041
name: non-proteinogenic amino acid metabolic process
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:83820 ! has primary input or output non-proteinogenic amino acid
relationship: RO:0004007 CHEBI:83820 ! has primary input or output non-proteinogenic amino acid
@@ -126528,7 +125713,6 @@ id: GO:0170043
name: non-proteinogenic amino acid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:83820 ! has primary output non-proteinogenic amino acid
relationship: RO:0004008 CHEBI:83820 ! has primary output non-proteinogenic amino acid
@@ -126538,7 +125722,6 @@ id: GO:0170044
name: non-proteinogenic amino acid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0170041 ! non-proteinogenic amino acid metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:83820 ! has primary input non-proteinogenic amino acid
relationship: RO:0004009 CHEBI:83820 ! has primary input non-proteinogenic amino acid
@@ -126587,15 +125770,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0043404 ! negatively regulates corticotropin-releasing hormone receptor activity
relationship: RO:0002212 GO:0043404 ! negatively regulates corticotropin-releasing hormone receptor activity
-[Term]
-id: GO:1900012
-name: positive regulation of corticotropin-releasing hormone receptor activity
-is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity
-is_a: GO:2000273 ! positive regulation of signaling receptor activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0043404 ! positively regulates corticotropin-releasing hormone receptor activity
-relationship: RO:0002213 GO:0043404 ! positively regulates corticotropin-releasing hormone receptor activity
-
[Term]
id: GO:1900015
name: regulation of cytokine production involved in inflammatory response
@@ -126695,20 +125869,20 @@ relationship: RO:0002213 GO:0006068 ! positively regulates ethanol catabolic pro
[Term]
id: GO:1900071
-name: regulation of sulfite transport
-is_a: GO:0051049 ! regulation of transport
+name: regulation of sulfite transmembrane transport
+is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0000316 ! regulates sulfite transport
-relationship: RO:0002211 GO:0000316 ! regulates sulfite transport
+intersection_of: RO:0002211 GO:0000316 ! regulates sulfite transmembrane transport
+relationship: RO:0002211 GO:0000316 ! regulates sulfite transmembrane transport
[Term]
id: GO:1900072
-name: positive regulation of sulfite transport
-is_a: GO:0051050 ! positive regulation of transport
-is_a: GO:1900071 ! regulation of sulfite transport
+name: positive regulation of sulfite transmembrane transport
+is_a: GO:1900071 ! regulation of sulfite transmembrane transport
+is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0000316 ! positively regulates sulfite transport
-relationship: RO:0002213 GO:0000316 ! positively regulates sulfite transport
+intersection_of: RO:0002213 GO:0000316 ! positively regulates sulfite transmembrane transport
+relationship: RO:0002213 GO:0000316 ! positively regulates sulfite transmembrane transport
[Term]
id: GO:1900073
@@ -126765,28 +125939,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0032869 ! positively regulates cellular response to insulin stimulus
relationship: RO:0002213 GO:0032869 ! positively regulates cellular response to insulin stimulus
-[Term]
-id: GO:1900079
-name: regulation of arginine biosynthetic process
-is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
-is_a: GO:0000821 ! regulation of arginine metabolic process
-is_a: GO:0031326 ! regulation of cellular biosynthetic process
-is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0006526 ! regulates arginine biosynthetic process
-relationship: RO:0002211 GO:0006526 ! regulates arginine biosynthetic process
-
-[Term]
-id: GO:1900080
-name: positive regulation of arginine biosynthetic process
-is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0062013 ! positive regulation of small molecule metabolic process
-is_a: GO:1900079 ! regulation of arginine biosynthetic process
-is_a: GO:2000284 ! positive regulation of amino acid biosynthetic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0006526 ! positively regulates arginine biosynthetic process
-relationship: RO:0002213 GO:0006526 ! positively regulates arginine biosynthetic process
-
[Term]
id: GO:1900081
name: regulation of arginine catabolic process
@@ -127021,12 +126173,12 @@ relationship: RO:0002213 GO:0002001 ! positively regulates renin secretion into
[Term]
id: GO:1900139
-name: negative regulation of arachidonic acid secretion
+name: negative regulation of arachidonate secretion
is_a: GO:0032304 ! negative regulation of icosanoid secretion
-is_a: GO:0090237 ! regulation of arachidonic acid secretion
+is_a: GO:0090237 ! regulation of arachidonate secretion
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0050482 ! negatively regulates arachidonic acid secretion
-relationship: RO:0002212 GO:0050482 ! negatively regulates arachidonic acid secretion
+intersection_of: RO:0002212 GO:0050482 ! negatively regulates arachidonate secretion
+relationship: RO:0002212 GO:0050482 ! negatively regulates arachidonate secretion
[Term]
id: GO:1900141
@@ -128557,7 +127709,7 @@ relationship: RO:0004009 CHEBI:30762 ! has primary input salicylate
[Term]
id: GO:1901160
name: primary amino compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:50994 ! has primary input or output primary amino compound
relationship: RO:0004007 CHEBI:50994 ! has primary input or output primary amino compound
@@ -128565,8 +127717,8 @@ relationship: RO:0004007 CHEBI:50994 ! has primary input or output primary amino
[Term]
id: GO:1901161
name: primary amino compound catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:1901160 ! primary amino compound metabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:50994 ! has primary input primary amino compound
relationship: RO:0004009 CHEBI:50994 ! has primary input primary amino compound
@@ -128574,8 +127726,8 @@ relationship: RO:0004009 CHEBI:50994 ! has primary input primary amino compound
[Term]
id: GO:1901162
name: primary amino compound biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901160 ! primary amino compound metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:50994 ! has primary output primary amino compound
relationship: RO:0004008 CHEBI:50994 ! has primary output primary amino compound
@@ -128882,10 +128034,9 @@ relationship: RO:0004009 CHEBI:25608 ! has primary input nucleoside phosphate
id: GO:1901289
name: succinyl-CoA catabolic process
is_a: GO:0006104 ! succinyl-CoA metabolic process
-is_a: GO:0009154 ! purine ribonucleotide catabolic process
-is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
-is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
+is_a: GO:0072523 ! purine-containing compound catabolic process
+is_a: GO:1901292 ! nucleoside phosphate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:57292 ! has primary input succinyl-CoA(5-)
relationship: RO:0004009 CHEBI:57292 ! has primary input succinyl-CoA(5-)
@@ -128970,8 +128121,8 @@ relationship: RO:0002212 GO:0030317 ! negatively regulates flagellated sperm mot
[Term]
id: GO:1901327
name: response to tacrolimus
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:61049 ! has primary input tacrolimus (anhydrous)
@@ -129074,8 +128225,8 @@ relationship: RO:0004009 CHEBI:5686 ! has primary input heterocyclic compound
[Term]
id: GO:1901367
name: response to L-cysteine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:35235 ! has primary input L-cysteine zwitterion
@@ -129084,7 +128235,7 @@ relationship: RO:0004009 CHEBI:35235 ! has primary input L-cysteine zwitterion
[Term]
id: GO:1901370
name: response to glutathione
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:57925 ! has primary input glutathionate(1-)
@@ -129322,9 +128473,10 @@ relationship: RO:0002213 GO:0033526 ! positively regulates tetrapyrrole biosynth
id: GO:1901413
name: regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
+is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
+is_a: GO:0019220 ! regulation of phosphate metabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0033527 ! regulates tetrapyrrole biosynthetic process from glycine and succinyl-CoA
@@ -129335,8 +128487,10 @@ id: GO:1901414
name: negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
+is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
+is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
+is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
@@ -129348,8 +128502,10 @@ id: GO:1901415
name: positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0045764 ! positive regulation of amino acid metabolic process
+is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
+is_a: GO:0045937 ! positive regulation of phosphate metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
+is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
@@ -129857,8 +129013,8 @@ intersection_of: RO:0004009 CHEBI:15792 ! has primary input malonate(2-)
[Term]
id: GO:1901556
name: response to candesartan
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:149509 ! has primary input candesartan(2-)
@@ -129877,7 +129033,7 @@ relationship: RO:0004009 CHEBI:5001 ! has primary input fenofibrate
[Term]
id: GO:1901558
name: response to metformin
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:6801 ! has primary input metformin
relationship: RO:0004009 CHEBI:6801 ! has primary input metformin
@@ -129885,8 +129041,8 @@ relationship: RO:0004009 CHEBI:6801 ! has primary input metformin
[Term]
id: GO:1901559
name: response to ribavirin
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:63580 ! has primary input ribavirin
@@ -129902,32 +129058,6 @@ intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:27656 ! has primary input camptothecin
relationship: RO:0004009 CHEBI:27656 ! has primary input camptothecin
-[Term]
-id: GO:1901564
-name: organonitrogen compound metabolic process
-is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:35352 ! has primary input or output organonitrogen compound
-relationship: RO:0004007 CHEBI:35352 ! has primary input or output organonitrogen compound
-
-[Term]
-id: GO:1901565
-name: organonitrogen compound catabolic process
-is_a: GO:0009056 ! catabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:35352 ! has primary input organonitrogen compound
-relationship: RO:0004009 CHEBI:35352 ! has primary input organonitrogen compound
-
-[Term]
-id: GO:1901566
-name: organonitrogen compound biosynthetic process
-is_a: GO:0009058 ! biosynthetic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: RO:0004008 CHEBI:35352 ! has primary output organonitrogen compound
-relationship: RO:0004008 CHEBI:35352 ! has primary output organonitrogen compound
-
[Term]
id: GO:1901567
name: fatty acid derivative binding
@@ -130017,7 +129147,6 @@ id: GO:1901605
name: alpha-amino acid metabolic process
is_a: GO:0006520 ! amino acid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino acid zwitterion
relationship: RO:0004007 CHEBI:78608 ! has primary input or output alpha-amino acid zwitterion
@@ -130027,7 +129156,6 @@ id: GO:1901606
name: alpha-amino acid catabolic process
is_a: GO:0009063 ! amino acid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:78608 ! has primary input alpha-amino acid zwitterion
@@ -130038,7 +129166,6 @@ id: GO:1901607
name: alpha-amino acid biosynthetic process
is_a: GO:0008652 ! amino acid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:78608 ! has primary output alpha-amino acid zwitterion
@@ -130368,7 +129495,6 @@ relationship: RO:0004009 CHEBI:26835 ! has primary input sulfur molecular entity
id: GO:1901685
name: glutathione derivative metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: RO:0004007 CHEBI:24337 ! has primary input or output glutathione derivative
relationship: RO:0004007 CHEBI:24337 ! has primary input or output glutathione derivative
@@ -130377,7 +129503,6 @@ relationship: RO:0004007 CHEBI:24337 ! has primary input or output glutathione d
id: GO:1901686
name: glutathione derivative catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
-is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901685 ! glutathione derivative metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: RO:0004009 CHEBI:24337 ! has primary input glutathione derivative
@@ -130387,7 +129512,6 @@ relationship: RO:0004009 CHEBI:24337 ! has primary input glutathione derivative
id: GO:1901687
name: glutathione derivative biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901685 ! glutathione derivative metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: RO:0004008 CHEBI:24337 ! has primary output glutathione derivative
@@ -131367,8 +130491,8 @@ intersection_of: RO:0004009 CHEBI:51349 ! has primary input polyamine macromolec
[Term]
id: GO:1902065
name: response to L-glutamate
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:29985 ! has primary input L-glutamate(1-)
@@ -131390,16 +130514,6 @@ is_a: GO:1902074 ! response to salt
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:24866 ! has primary input salt
-[Term]
-id: GO:1902079
-name: D-valine catabolic process
-is_a: GO:0006574 ! valine catabolic process
-is_a: GO:0019478 ! D-amino acid catabolic process
-is_a: GO:1902114 ! D-valine metabolic process
-intersection_of: GO:0009056 ! catabolic process
-intersection_of: RO:0004009 CHEBI:74338 ! has primary input D-valine zwitterion
-relationship: RO:0004009 CHEBI:74338 ! has primary input D-valine zwitterion
-
[Term]
id: GO:1902080
name: regulation of calcium ion import into sarcoplasmic reticulum
@@ -131550,15 +130664,6 @@ is_a: GO:1902686 ! mitochondrial outer membrane permeabilization involved in pro
intersection_of: GO:0035794 ! positive regulation of mitochondrial membrane permeability
intersection_of: BFO:0000050 GO:0006915 ! part of apoptotic process
-[Term]
-id: GO:1902114
-name: D-valine metabolic process
-is_a: GO:0006573 ! valine metabolic process
-is_a: GO:0046416 ! D-amino acid metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: RO:0004007 CHEBI:74338 ! has primary input or output D-valine zwitterion
-relationship: RO:0004007 CHEBI:74338 ! has primary input or output D-valine zwitterion
-
[Term]
id: GO:1902115
name: regulation of organelle assembly
@@ -132117,10 +131222,11 @@ intersection_of: RO:0004009 CHEBI:16452 ! has primary input oxaloacetate(2-)
[Term]
id: GO:1902358
name: sulfate transmembrane transport
-is_a: GO:0008272 ! sulfate transport
+is_a: GO:0072348 ! sulfur compound transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: RO:0004009 CHEBI:16189 ! has primary input sulfate
+relationship: RO:0004009 CHEBI:16189 ! has primary input sulfate
[Term]
id: GO:1902362
@@ -132192,16 +131298,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0015250 ! regulates water channel activity
relationship: RO:0002211 GO:0015250 ! regulates water channel activity
-[Term]
-id: GO:1902428
-name: negative regulation of water channel activity
-is_a: GO:0032410 ! negative regulation of transporter activity
-is_a: GO:0034763 ! negative regulation of transmembrane transport
-is_a: GO:1902427 ! regulation of water channel activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0015250 ! negatively regulates water channel activity
-relationship: RO:0002212 GO:0015250 ! negatively regulates water channel activity
-
[Term]
id: GO:1902429
name: positive regulation of water channel activity
@@ -132212,14 +131308,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0015250 ! positively regulates water channel activity
relationship: RO:0002213 GO:0015250 ! positively regulates water channel activity
-[Term]
-id: GO:1902433
-name: positive regulation of water channel activity involved in maintenance of lens transparency
-is_a: GO:1902429 ! positive regulation of water channel activity
-intersection_of: GO:1902429 ! positive regulation of water channel activity
-intersection_of: BFO:0000050 GO:0036438 ! part of maintenance of lens transparency
-relationship: BFO:0000050 GO:0036438 ! part of maintenance of lens transparency
-
[Term]
id: GO:1902434
name: sulfate import across plasma membrane
@@ -132451,7 +131539,7 @@ relationship: RO:0002211 GO:0072384 ! regulates organelle transport along microt
id: GO:1902518
name: response to cyclophosphamide
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:4027 ! has primary input cyclophosphamide
relationship: RO:0004009 CHEBI:4027 ! has primary input cyclophosphamide
@@ -132513,15 +131601,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0004096 ! regulates catalase activity
relationship: RO:0002211 GO:0004096 ! regulates catalase activity
-[Term]
-id: GO:1902552
-name: negative regulation of catalase activity
-is_a: GO:1902551 ! regulation of catalase activity
-is_a: GO:2000469 ! negative regulation of peroxidase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0004096 ! negatively regulates catalase activity
-relationship: RO:0002212 GO:0004096 ! negatively regulates catalase activity
-
[Term]
id: GO:1902553
name: positive regulation of catalase activity
@@ -132849,7 +131928,6 @@ relationship: RO:0002213 GO:0019674 ! positively regulates NAD metabolic process
id: GO:1902691
name: respiratory basal cell differentiation
comment: Changes in the lineage choice of ABCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders
-is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0002633 ! results in acquisition of features of respiratory basal cell
@@ -133009,24 +132087,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0004102 ! regulates choline O-acetyltransferase activity
relationship: RO:0002211 GO:0004102 ! regulates choline O-acetyltransferase activity
-[Term]
-id: GO:1902770
-name: negative regulation of choline O-acetyltransferase activity
-is_a: GO:0051348 ! negative regulation of transferase activity
-is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0004102 ! negatively regulates choline O-acetyltransferase activity
-relationship: RO:0002212 GO:0004102 ! negatively regulates choline O-acetyltransferase activity
-
-[Term]
-id: GO:1902771
-name: positive regulation of choline O-acetyltransferase activity
-is_a: GO:0051347 ! positive regulation of transferase activity
-is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0004102 ! positively regulates choline O-acetyltransferase activity
-relationship: RO:0002213 GO:0004102 ! positively regulates choline O-acetyltransferase activity
-
[Term]
id: GO:1902774
name: late endosome to lysosome transport
@@ -133608,17 +132668,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0005247 ! regulates voltage-gated chloride channel activity
relationship: RO:0002211 GO:0005247 ! regulates voltage-gated chloride channel activity
-[Term]
-id: GO:1902942
-name: negative regulation of voltage-gated chloride channel activity
-is_a: GO:0010360 ! negative regulation of anion channel activity
-is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity
-is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
-is_a: GO:2001226 ! negative regulation of chloride transport
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0005247 ! negatively regulates voltage-gated chloride channel activity
-relationship: RO:0002212 GO:0005247 ! negatively regulates voltage-gated chloride channel activity
-
[Term]
id: GO:1902943
name: positive regulation of voltage-gated chloride channel activity
@@ -133884,16 +132933,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0022848 ! regulates acetylcholine-gated monoatomic cation-selective channel activity
relationship: RO:0002211 GO:0022848 ! regulates acetylcholine-gated monoatomic cation-selective channel activity
-[Term]
-id: GO:1903049
-name: negative regulation of acetylcholine-gated cation channel activity
-is_a: GO:1903048 ! regulation of acetylcholine-gated cation channel activity
-is_a: GO:2000272 ! negative regulation of signaling receptor activity
-is_a: GO:2001258 ! negative regulation of cation channel activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0022848 ! negatively regulates acetylcholine-gated monoatomic cation-selective channel activity
-relationship: RO:0002212 GO:0022848 ! negatively regulates acetylcholine-gated monoatomic cation-selective channel activity
-
[Term]
id: GO:1903050
name: regulation of proteolysis involved in protein catabolic process
@@ -134121,7 +133160,6 @@ relationship: BFO:0000050 GO:0051285 ! part of cell cortex of cell tip
id: GO:1903146
name: regulation of autophagy of mitochondrion
is_a: GO:0010506 ! regulation of autophagy
-is_a: GO:0010821 ! regulation of mitochondrion organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0000422 ! regulates autophagy of mitochondrion
relationship: RO:0002211 GO:0000422 ! regulates autophagy of mitochondrion
@@ -134130,7 +133168,6 @@ relationship: RO:0002211 GO:0000422 ! regulates autophagy of mitochondrion
id: GO:1903147
name: negative regulation of autophagy of mitochondrion
is_a: GO:0010507 ! negative regulation of autophagy
-is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1903146 ! regulation of autophagy of mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0000422 ! negatively regulates autophagy of mitochondrion
@@ -134210,15 +133247,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0004511 ! regulates tyrosine 3-monooxygenase activity
relationship: RO:0002211 GO:0004511 ! regulates tyrosine 3-monooxygenase activity
-[Term]
-id: GO:1903177
-name: negative regulation of tyrosine 3-monooxygenase activity
-is_a: GO:0032769 ! negative regulation of monooxygenase activity
-is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0004511 ! negatively regulates tyrosine 3-monooxygenase activity
-relationship: RO:0002212 GO:0004511 ! negatively regulates tyrosine 3-monooxygenase activity
-
[Term]
id: GO:1903178
name: positive regulation of tyrosine 3-monooxygenase activity
@@ -134483,7 +133511,7 @@ relationship: RO:0002213 GO:0019240 ! positively regulates citrulline biosynthet
[Term]
id: GO:1903251
name: multi-ciliated epithelial cell differentiation
-is_a: GO:0030855 ! epithelial cell differentiation
+is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: RO:0002315 CL:0005012 ! results in acquisition of features of multi-ciliated epithelial cell
relationship: RO:0002315 CL:0005012 ! results in acquisition of features of multi-ciliated epithelial cell
@@ -134563,15 +133591,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0004602 ! regulates glutathione peroxidase activity
relationship: RO:0002211 GO:0004602 ! regulates glutathione peroxidase activity
-[Term]
-id: GO:1903283
-name: negative regulation of glutathione peroxidase activity
-is_a: GO:1903282 ! regulation of glutathione peroxidase activity
-is_a: GO:2000469 ! negative regulation of peroxidase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0004602 ! negatively regulates glutathione peroxidase activity
-relationship: RO:0002212 GO:0004602 ! negatively regulates glutathione peroxidase activity
-
[Term]
id: GO:1903284
name: positive regulation of glutathione peroxidase activity
@@ -134705,25 +133724,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0004743 ! regulates pyruvate kinase activity
relationship: RO:0002211 GO:0004743 ! regulates pyruvate kinase activity
-[Term]
-id: GO:1903303
-name: negative regulation of pyruvate kinase activity
-is_a: GO:0045820 ! negative regulation of glycolytic process
-is_a: GO:0051348 ! negative regulation of transferase activity
-is_a: GO:1903302 ! regulation of pyruvate kinase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0004743 ! negatively regulates pyruvate kinase activity
-relationship: RO:0002212 GO:0004743 ! negatively regulates pyruvate kinase activity
-
-[Term]
-id: GO:1903304
-name: positive regulation of pyruvate kinase activity
-is_a: GO:0051347 ! positive regulation of transferase activity
-is_a: GO:1903302 ! regulation of pyruvate kinase activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0004743 ! positively regulates pyruvate kinase activity
-relationship: RO:0002213 GO:0004743 ! positively regulates pyruvate kinase activity
-
[Term]
id: GO:1903305
name: regulation of regulated secretory pathway
@@ -135138,8 +134138,8 @@ relationship: RO:0004009 CHEBI:13719 ! has primary input acetylsalicylate
[Term]
id: GO:1903493
name: response to clopidogrel
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:37941 ! has primary input clopidogrel
@@ -135624,7 +134624,6 @@ id: GO:1903599
name: positive regulation of autophagy of mitochondrion
comment: An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay
is_a: GO:0010508 ! positive regulation of autophagy
-is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1903146 ! regulation of autophagy of mitochondrion
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0000422 ! positively regulates autophagy of mitochondrion
@@ -136075,16 +135074,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0098719 ! positively regulates sodium ion import across plasma membrane
relationship: RO:0002213 GO:0098719 ! positively regulates sodium ion import across plasma membrane
-[Term]
-id: GO:1903785
-name: L-valine transmembrane transport
-is_a: GO:0015695 ! organic cation transport
-is_a: GO:0015829 ! valine transport
-is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
-intersection_of: GO:0055085 ! transmembrane transport
-intersection_of: RO:0004009 CHEBI:57762 ! has primary input L-valine zwitterion
-relationship: RO:0004009 CHEBI:57762 ! has primary input L-valine zwitterion
-
[Term]
id: GO:1903786
name: regulation of glutathione biosynthetic process
@@ -136226,17 +135215,6 @@ intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:57305 ! has primary input glycine zwitterion
-[Term]
-id: GO:1903805
-name: L-valine import across plasma membrane
-is_a: GO:0089718 ! amino acid import across plasma membrane
-is_a: GO:1903785 ! L-valine transmembrane transport
-intersection_of: GO:0006810 ! transport
-intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
-intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
-intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
-intersection_of: RO:0004009 CHEBI:57762 ! has primary input L-valine zwitterion
-
[Term]
id: GO:1903808
name: L-tyrosine import across plasma membrane
@@ -137631,16 +136609,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005381 ! negatively regulates iron ion transmembrane transporter activity
relationship: RO:0002212 GO:0005381 ! negatively regulates iron ion transmembrane transporter activity
-[Term]
-id: GO:1904256
-name: positive regulation of iron ion transmembrane transporter activity
-is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
-is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport
-is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0005381 ! positively regulates iron ion transmembrane transporter activity
-relationship: RO:0002213 GO:0005381 ! positively regulates iron ion transmembrane transporter activity
-
[Term]
id: GO:1904266
name: regulation of Schwann cell chemotaxis
@@ -137690,15 +136658,15 @@ intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma memb
intersection_of: RO:0004009 CHEBI:60039 ! has primary input L-proline zwitterion
[Term]
-id: GO:1904273
-name: L-alanine import across plasma membrane
+id: GO:1904272
+name: L-tryptophan import across plasma membrane
is_a: GO:0089718 ! amino acid import across plasma membrane
-is_a: GO:1904557 ! L-alanine transmembrane transport
+is_a: GO:1904556 ! L-tryptophan transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002338 GO:0005576 ! has target start location extracellular region
intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
+intersection_of: RO:0004009 CHEBI:57912 ! has primary input L-tryptophan zwitterion
[Term]
id: GO:1904292
@@ -138033,7 +137001,7 @@ relationship: RO:0002213 GO:1990778 ! positively regulates protein localization
[Term]
id: GO:1904386
name: response to L-phenylalanine derivative
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:84144 ! has primary input L-phenylalanine derivative
relationship: RO:0004009 CHEBI:84144 ! has primary input L-phenylalanine derivative
@@ -138041,7 +137009,7 @@ relationship: RO:0004009 CHEBI:84144 ! has primary input L-phenylalanine derivat
[Term]
id: GO:1904387
name: cellular response to L-phenylalanine derivative
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904386 ! response to L-phenylalanine derivative
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:84144 ! has primary input L-phenylalanine derivative
@@ -138065,7 +137033,7 @@ relationship: RO:0002315 CL:0000752 ! results in acquisition of features of cone
[Term]
id: GO:1904391
name: response to ciliary neurotrophic factor
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 PR:000005663 ! has primary input ciliary neurotrophic factor
relationship: RO:0004009 PR:000005663 ! has primary input ciliary neurotrophic factor
@@ -138073,7 +137041,7 @@ relationship: RO:0004009 PR:000005663 ! has primary input ciliary neurotrophic f
[Term]
id: GO:1904392
name: cellular response to ciliary neurotrophic factor
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904391 ! response to ciliary neurotrophic factor
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 PR:000005663 ! has primary input ciliary neurotrophic factor
@@ -138249,38 +137217,6 @@ intersection_of: RO:0002339 GO:0005829 ! has target end location cytosol
intersection_of: RO:0002342 GO:0005886 ! results in transport across plasma membrane
intersection_of: RO:0004009 CHEBI:62501 ! has primary input folate(2-)
-[Term]
-id: GO:1904448
-name: regulation of aspartate secretion
-is_a: GO:0032890 ! regulation of organic acid transport
-is_a: GO:0051955 ! regulation of amino acid transport
-is_a: GO:1903530 ! regulation of secretion by cell
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0061528 ! regulates aspartate secretion
-relationship: RO:0002211 GO:0061528 ! regulates aspartate secretion
-
-[Term]
-id: GO:1904449
-name: negative regulation of aspartate secretion
-is_a: GO:0032891 ! negative regulation of organic acid transport
-is_a: GO:0051956 ! negative regulation of amino acid transport
-is_a: GO:1903531 ! negative regulation of secretion by cell
-is_a: GO:1904448 ! regulation of aspartate secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0061528 ! negatively regulates aspartate secretion
-relationship: RO:0002212 GO:0061528 ! negatively regulates aspartate secretion
-
-[Term]
-id: GO:1904450
-name: positive regulation of aspartate secretion
-is_a: GO:0032892 ! positive regulation of organic acid transport
-is_a: GO:0051957 ! positive regulation of amino acid transport
-is_a: GO:1903532 ! positive regulation of secretion by cell
-is_a: GO:1904448 ! regulation of aspartate secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0061528 ! positively regulates aspartate secretion
-relationship: RO:0002213 GO:0061528 ! positively regulates aspartate secretion
-
[Term]
id: GO:1904456
name: negative regulation of neuronal action potential
@@ -138453,7 +137389,7 @@ relationship: RO:0002213 GO:0008017 ! positively regulates microtubule binding
[Term]
id: GO:1904550
-name: response to arachidonic acid
+name: response to arachidonate
is_a: GO:0070542 ! response to fatty acid
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:32395 ! has primary input arachidonate
@@ -138461,37 +137397,37 @@ relationship: RO:0004009 CHEBI:32395 ! has primary input arachidonate
[Term]
id: GO:1904551
-name: cellular response to arachidonic acid
+name: cellular response to arachidonate
is_a: GO:0071398 ! cellular response to fatty acid
-is_a: GO:1904550 ! response to arachidonic acid
+is_a: GO:1904550 ! response to arachidonate
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:32395 ! has primary input arachidonate
[Term]
id: GO:1904552
-name: regulation of chemotaxis to arachidonic acid
+name: regulation of chemotaxis to arachidonate
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002211 GO:0034670 ! regulates chemotaxis to arachidonic acid
-relationship: RO:0002211 GO:0034670 ! regulates chemotaxis to arachidonic acid
+intersection_of: RO:0002211 GO:0034670 ! regulates chemotaxis to arachidonate
+relationship: RO:0002211 GO:0034670 ! regulates chemotaxis to arachidonate
[Term]
id: GO:1904553
-name: negative regulation of chemotaxis to arachidonic acid
+name: negative regulation of chemotaxis to arachidonate
is_a: GO:0050922 ! negative regulation of chemotaxis
-is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid
+is_a: GO:1904552 ! regulation of chemotaxis to arachidonate
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0034670 ! negatively regulates chemotaxis to arachidonic acid
-relationship: RO:0002212 GO:0034670 ! negatively regulates chemotaxis to arachidonic acid
+intersection_of: RO:0002212 GO:0034670 ! negatively regulates chemotaxis to arachidonate
+relationship: RO:0002212 GO:0034670 ! negatively regulates chemotaxis to arachidonate
[Term]
id: GO:1904554
-name: positive regulation of chemotaxis to arachidonic acid
+name: positive regulation of chemotaxis to arachidonate
is_a: GO:0050921 ! positive regulation of chemotaxis
-is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid
+is_a: GO:1904552 ! regulation of chemotaxis to arachidonate
intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0034670 ! positively regulates chemotaxis to arachidonic acid
-relationship: RO:0002213 GO:0034670 ! positively regulates chemotaxis to arachidonic acid
+intersection_of: RO:0002213 GO:0034670 ! positively regulates chemotaxis to arachidonate
+relationship: RO:0002213 GO:0034670 ! positively regulates chemotaxis to arachidonate
[Term]
id: GO:1904555
@@ -138505,12 +137441,13 @@ intersection_of: RO:0004009 CHEBI:60039 ! has primary input L-proline zwitterion
relationship: RO:0004009 CHEBI:60039 ! has primary input L-proline zwitterion
[Term]
-id: GO:1904557
-name: L-alanine transmembrane transport
-is_a: GO:0015808 ! L-alanine transport
+id: GO:1904556
+name: L-tryptophan transmembrane transport
+is_a: GO:0015827 ! tryptophan transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
-intersection_of: RO:0004009 CHEBI:57972 ! has primary input L-alanine zwitterion
+intersection_of: RO:0004009 CHEBI:57912 ! has primary input L-tryptophan zwitterion
+relationship: RO:0004009 CHEBI:57912 ! has primary input L-tryptophan zwitterion
[Term]
id: GO:1904572
@@ -138524,7 +137461,7 @@ relationship: RO:0002212 GO:0003729 ! negatively regulates mRNA binding
[Term]
id: GO:1904583
name: response to polyamine macromolecule
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:51349 ! has primary input polyamine macromolecule
relationship: RO:0004009 CHEBI:51349 ! has primary input polyamine macromolecule
@@ -138532,7 +137469,7 @@ relationship: RO:0004009 CHEBI:51349 ! has primary input polyamine macromolecule
[Term]
id: GO:1904584
name: cellular response to polyamine macromolecule
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1904583 ! response to polyamine macromolecule
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:51349 ! has primary input polyamine macromolecule
@@ -138540,7 +137477,7 @@ intersection_of: RO:0004009 CHEBI:51349 ! has primary input polyamine macromolec
[Term]
id: GO:1904587
name: response to glycoprotein
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:17089 ! has primary input glycoprotein
@@ -138549,7 +137486,7 @@ relationship: RO:0004009 CHEBI:17089 ! has primary input glycoprotein
[Term]
id: GO:1904588
name: cellular response to glycoprotein
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904587 ! response to glycoprotein
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -138679,8 +137616,8 @@ relationship: RO:0002213 GO:1903210 ! positively regulates podocyte apoptotic pr
[Term]
id: GO:1904640
name: response to methionine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:64558 ! has primary input methionine zwitterion
@@ -138768,7 +137705,7 @@ relationship: RO:0002213 GO:0050916 ! positively regulates sensory perception of
[Term]
id: GO:1904659
-name: glucose transmembrane transport
+name: D-glucose transmembrane transport
is_a: GO:0008645 ! hexose transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
@@ -139427,8 +138364,8 @@ relationship: RO:0002298 UBERON:0012175 ! results in morphogenesis of acoustico-
[Term]
id: GO:1904844
name: response to L-glutamine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:58359 ! has primary input L-glutamine zwitterion
@@ -139438,7 +138375,7 @@ relationship: RO:0004009 CHEBI:58359 ! has primary input L-glutamine zwitterion
id: GO:1904845
name: cellular response to L-glutamine
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904844 ! response to L-glutamine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -139876,7 +138813,7 @@ relationship: RO:0002588 GO:0005903 ! results in assembly of brush border
[Term]
id: GO:1904975
name: response to bleomycin
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:22907 ! has primary input bleomycin
@@ -139885,7 +138822,7 @@ relationship: RO:0004009 CHEBI:22907 ! has primary input bleomycin
[Term]
id: GO:1904976
name: cellular response to bleomycin
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904975 ! response to bleomycin
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -140341,10 +139278,10 @@ relationship: RO:0002213 GO:0101010 ! positively regulates pulmonary blood vesse
id: GO:1905119
name: response to haloperidol
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
+is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:5613 ! has primary input haloperidol
relationship: RO:0004009 CHEBI:5613 ! has primary input haloperidol
@@ -140354,9 +139291,9 @@ id: GO:1905120
name: cellular response to haloperidol
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1905119 ! response to haloperidol
intersection_of: GO:0070887 ! cellular response to chemical stimulus
intersection_of: RO:0004009 CHEBI:5613 ! has primary input haloperidol
@@ -140565,24 +139502,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0010324 ! positively regulates membrane invagination
relationship: RO:0002213 GO:0010324 ! positively regulates membrane invagination
-[Term]
-id: GO:1905156
-name: negative regulation of photosynthesis
-is_a: GO:0010109 ! regulation of photosynthesis
-is_a: GO:0031324 ! negative regulation of cellular metabolic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0015979 ! negatively regulates photosynthesis
-relationship: RO:0002212 GO:0015979 ! negatively regulates photosynthesis
-
-[Term]
-id: GO:1905157
-name: positive regulation of photosynthesis
-is_a: GO:0010109 ! regulation of photosynthesis
-is_a: GO:0031325 ! positive regulation of cellular metabolic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0015979 ! positively regulates photosynthesis
-relationship: RO:0002213 GO:0015979 ! positively regulates photosynthesis
-
[Term]
id: GO:1905165
name: regulation of lysosomal protein catabolic process
@@ -140795,7 +139714,7 @@ relationship: RO:0002298 UBERON:0002348 ! results in morphogenesis of epicardium
id: GO:1905232
name: cellular response to L-glutamate
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902065 ! response to L-glutamate
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -140804,7 +139723,7 @@ intersection_of: RO:0004009 CHEBI:29985 ! has primary input L-glutamate(1-)
[Term]
id: GO:1905237
name: response to cyclosporin A
-is_a: GO:0010243 ! response to organonitrogen compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:4031 ! has primary input cyclosporin A
@@ -140813,7 +139732,7 @@ relationship: RO:0004009 CHEBI:4031 ! has primary input cyclosporin A
[Term]
id: GO:1905238
name: cellular response to cyclosporin A
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905237 ! response to cyclosporin A
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -140822,9 +139741,9 @@ intersection_of: RO:0004009 CHEBI:4031 ! has primary input cyclosporin A
[Term]
id: GO:1905242
name: response to 3,3',5-triiodo-L-thyronine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:533015 ! has primary input 3,3',5-triiodo-L-thyronine zwitterion
@@ -140835,7 +139754,7 @@ id: GO:1905243
name: cellular response to 3,3',5-triiodo-L-thyronine
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905242 ! response to 3,3',5-triiodo-L-thyronine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -140877,16 +139796,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0046933 ! regulates proton-transporting ATP synthase activity, rotational mechanism
relationship: RO:0002211 GO:0046933 ! regulates proton-transporting ATP synthase activity, rotational mechanism
-[Term]
-id: GO:1905272
-name: negative regulation of proton-transporting ATP synthase activity, rotational mechanism
-is_a: GO:0051352 ! negative regulation of ligase activity
-is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism
-is_a: GO:2001258 ! negative regulation of cation channel activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002212 GO:0046933 ! negatively regulates proton-transporting ATP synthase activity, rotational mechanism
-relationship: RO:0002212 GO:0046933 ! negatively regulates proton-transporting ATP synthase activity, rotational mechanism
-
[Term]
id: GO:1905273
name: positive regulation of proton-transporting ATP synthase activity, rotational mechanism
@@ -141331,8 +140240,8 @@ relationship: RO:0004008 CHEBI:73202 ! has primary output ceramide phosphoethano
[Term]
id: GO:1905374
name: response to homocysteine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:58065 ! has primary input homocysteine zwitterion
@@ -141342,7 +140251,7 @@ relationship: RO:0004009 CHEBI:58065 ! has primary input homocysteine zwitterion
id: GO:1905375
name: cellular response to homocysteine
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905374 ! response to homocysteine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -141526,15 +140435,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0005308 ! negatively regulates creatine transmembrane transporter activity
relationship: RO:0002212 GO:0005308 ! negatively regulates creatine transmembrane transporter activity
-[Term]
-id: GO:1905409
-name: positive regulation of creatine transmembrane transporter activity
-is_a: GO:0032411 ! positive regulation of transporter activity
-is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: RO:0002213 GO:0005308 ! positively regulates creatine transmembrane transporter activity
-relationship: RO:0002213 GO:0005308 ! positively regulates creatine transmembrane transporter activity
-
[Term]
id: GO:1905413
name: regulation of dense core granule exocytosis
@@ -141601,8 +140501,8 @@ relationship: RO:0002211 GO:1905393 ! regulates plant organ formation
[Term]
id: GO:1905429
name: response to glycine
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0043200 ! response to amino acid
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:57305 ! has primary input glycine zwitterion
@@ -141612,7 +140512,7 @@ relationship: RO:0004009 CHEBI:57305 ! has primary input glycine zwitterion
id: GO:1905430
name: cellular response to glycine
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905429 ! response to glycine
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -142921,9 +141821,9 @@ relationship: RO:0002212 GO:0007020 ! negatively regulates microtubule nucleatio
[Term]
id: GO:1905834
name: response to pyrimidine ribonucleotide
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0046683 ! response to organophosphorus
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:26446 ! has primary input pyrimidine ribonucleotide
@@ -142933,7 +141833,7 @@ relationship: RO:0004009 CHEBI:26446 ! has primary input pyrimidine ribonucleoti
id: GO:1905835
name: cellular response to pyrimidine ribonucleotide
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071417 ! cellular response to organonitrogen compound
+is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905834 ! response to pyrimidine ribonucleotide
intersection_of: GO:0070887 ! cellular response to chemical stimulus
@@ -143514,8 +142414,8 @@ intersection_of: RO:0004009 CHEBI:18059 ! has primary input lipid
id: GO:1990054
name: response to temozolomide
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
-is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
+is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: RO:0004009 CHEBI:72564 ! has primary input temozolomide
@@ -143919,14 +142819,6 @@ intersection_of: RO:0002339 GO:0005775 ! has target end location vacuolar lumen
intersection_of: RO:0002342 GO:0016020 ! results in transport across membrane
intersection_of: RO:0004009 CHEBI:22653 ! has primary input asparagine
-[Term]
-id: GO:1990610
-name: acetolactate synthase regulator activity
-is_a: GO:0030234 ! enzyme regulator activity
-intersection_of: GO:0098772 ! molecular function regulator activity
-intersection_of: RO:0002578 GO:0003984 ! directly regulates acetolactate synthase activity
-relationship: RO:0002578 GO:0003984 ! directly regulates acetolactate synthase activity
-
[Term]
id: GO:1990611
name: regulation of cytoplasmic translational initiation in response to stress
@@ -144274,8 +143166,10 @@ relationship: RO:0002213 GO:0034394 ! positively regulates protein localization
[Term]
id: GO:2000013
name: regulation of arginine biosynthetic process via ornithine
+is_a: GO:0000821 ! regulation of arginine metabolic process
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0090368 ! regulation of ornithine metabolic process
-is_a: GO:1900079 ! regulation of arginine biosynthetic process
+is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0042450 ! regulates arginine biosynthetic process via ornithine
relationship: RO:0002211 GO:0042450 ! regulates arginine biosynthetic process via ornithine
@@ -145595,7 +144489,7 @@ relationship: RO:0002213 GO:0072574 ! positively regulates hepatocyte proliferat
[Term]
id: GO:2000351
name: regulation of endothelial cell apoptotic process
-is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
+is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process
relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process
@@ -145603,7 +144497,7 @@ relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic proce
[Term]
id: GO:2000352
name: negative regulation of endothelial cell apoptotic process
-is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
+is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apoptotic process
@@ -145612,7 +144506,7 @@ relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apop
[Term]
id: GO:2000353
name: positive regulation of endothelial cell apoptotic process
-is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
+is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: RO:0002213 GO:0072577 ! positively regulates endothelial cell apoptotic process
@@ -154235,6 +153129,11 @@ id: HP:0003159
name: Hyperoxaluria
is_a: HP:0001992 ! Organic aciduria
+[Term]
+id: HP:0003161
+name: 4-Hydroxyphenylpyruvic aciduria
+is_a: HP:0040156 ! Elevated urinary carboxylic acid
+
[Term]
id: HP:0003163
name: Elevated urinary delta-aminolevulinic acid
@@ -160417,11 +159316,6 @@ name: Muscle hypertrophy of the lower extremities
is_a: HP:0001437 ! Abnormality of the musculature of the lower limbs
is_a: HP:0003712 ! Skeletal muscle hypertrophy
-[Term]
-id: HP:0008972
-name: Decreased activity of mitochondrial respiratory chain
-is_a: HP:0011922 ! Abnormal activity of mitochondrial respiratory chain
-
[Term]
id: HP:0008981
name: Calf muscle hypertrophy
@@ -168008,16 +166902,6 @@ name: Short 5th toe
is_a: HP:0001831 ! Short toe
is_a: HP:0010322 ! Abnormal fifth toe morphology
-[Term]
-id: HP:0011922
-name: Abnormal activity of mitochondrial respiratory chain
-is_a: HP:0003287 ! Abnormality of mitochondrial metabolism
-
-[Term]
-id: HP:0011925
-name: Decreased activity of mitochondrial ATP synthase complex
-is_a: HP:0008972 ! Decreased activity of mitochondrial respiratory chain
-
[Term]
id: HP:0011927
name: Short digit
@@ -171847,12 +170731,6 @@ name: Neuroinflammation
def: "Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain." []
is_a: HP:0012649 ! Increased inflammatory response
-[Term]
-id: HP:0033435
-name: Abnormal circulating keto acid concentration
-def: "A deviation from the normal concentration of a keto acid in the blood circulation. Keto acids or ketoacids are organic compounds that contain a carboxylic acid group and a ketone group." []
-is_a: HP:0010996 ! Abnormal circulating monocarboxylic acid concentration
-
[Term]
id: HP:0033479
name: Abnormal circulating bilirubin concentration
@@ -172289,11 +171167,6 @@ id: HP:0040014
name: Increased mitochondrial number
is_a: HP:0012102 ! Abnormal mitochondrial number
-[Term]
-id: HP:0040015
-name: Increased activity of mitochondrial respiratory chain
-is_a: HP:0011922 ! Abnormal activity of mitochondrial respiratory chain
-
[Term]
id: HP:0040017
name: Protruding coccyx
@@ -177340,7 +176213,7 @@ is_a: MONDO:0000477 ! focal dystonia
is_a: MONDO:0020120 ! skeletal muscle disorder
intersection_of: MONDO:0000477 ! focal dystonia
intersection_of: RO:0004026 UBERON:0004832 ! disease has location anal region skeletal muscle
-relationship: RO:0004024 GO:0030421 ! disease causes disruption of defecation
+relationship: RO:0004024 GO:0030421 ! disease disrupts defecation
relationship: RO:0004026 UBERON:0004832 ! disease has location anal region skeletal muscle
[Term]
@@ -177812,13 +176685,8 @@ id: MONDO:0000721
name: xanthinuria
is_a: MONDO:0005066 ! metabolic disease
intersection_of: MONDO:0005066 ! metabolic disease
-intersection_of: RO:0004024 GO:0046110 ! disease causes disruption of xanthine metabolic process
-relationship: RO:0004024 GO:0046110 ! disease causes disruption of xanthine metabolic process
-
-[Term]
-id: MONDO:0000732
-name: combined oxidative phosphorylation deficiency
-is_a: MONDO:0016387 ! mitochondrial oxidative phosphorylation disorder
+intersection_of: RO:0004024 GO:0046110 ! disease disrupts xanthine metabolic process
+relationship: RO:0004024 GO:0046110 ! disease disrupts xanthine metabolic process
[Term]
id: MONDO:0000739
@@ -177893,8 +176761,8 @@ id: MONDO:0000833
name: bone remodeling disease
is_a: MONDO:0005381 ! bone disorder
intersection_of: MONDO:0005381 ! bone disorder
-intersection_of: RO:0004024 GO:0046849 ! disease causes disruption of bone remodeling
-relationship: RO:0004024 GO:0046849 ! disease causes disruption of bone remodeling
+intersection_of: RO:0004024 GO:0046849 ! disease disrupts bone remodeling
+relationship: RO:0004024 GO:0046849 ! disease disrupts bone remodeling
[Term]
id: MONDO:0000837
@@ -177902,8 +176770,8 @@ name: bone resorption disease
def: "A disease that has its basis in the disruption of bone resorption. Bone resorption is a process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." []
is_a: MONDO:0000833 ! bone remodeling disease
intersection_of: MONDO:0000833 ! bone remodeling disease
-intersection_of: RO:0004024 GO:0045453 ! disease causes disruption of bone resorption
-relationship: RO:0004024 GO:0045453 ! disease causes disruption of bone resorption
+intersection_of: RO:0004024 GO:0045453 ! disease disrupts bone resorption
+relationship: RO:0004024 GO:0045453 ! disease disrupts bone resorption
[Term]
id: MONDO:0000888
@@ -178085,8 +176953,8 @@ id: MONDO:0000992
name: heart conduction disease
is_a: MONDO:0005267 ! heart disorder
intersection_of: MONDO:0005267 ! heart disorder
-intersection_of: RO:0004024 GO:0061337 ! disease causes disruption of cardiac conduction
-relationship: RO:0004024 GO:0061337 ! disease causes disruption of cardiac conduction
+intersection_of: RO:0004024 GO:0061337 ! disease disrupts cardiac conduction
+relationship: RO:0004024 GO:0061337 ! disease disrupts cardiac conduction
[Term]
id: MONDO:0000993
@@ -178345,6 +177213,12 @@ intersection_of: MONDO:0000001 ! disease
intersection_of: RO:0004026 UBERON:0001044 ! disease has location saliva-secreting gland
relationship: RO:0004026 UBERON:0001044 ! disease has location saliva-secreting gland
+[Term]
+id: MONDO:0001149
+name: microcephaly
+is_a: MONDO:0021147 ! disorder of development or morphogenesis
+is_a: MONDO:0700092 ! neurodevelopmental disorder
+
[Term]
id: MONDO:0001165
name: tongue disorder
@@ -178644,8 +177518,8 @@ name: iron deficiency anemia
is_a: MONDO:0000387 ! hypochromic microcytic anemia
is_a: MONDO:0006873 ! nutritional deficiency disease
intersection_of: MONDO:0002280 ! anemia
-intersection_of: RO:0004024 GO:0006879 ! disease causes disruption of intracellular iron ion homeostasis
-relationship: RO:0004024 GO:0006879 ! disease causes disruption of intracellular iron ion homeostasis
+intersection_of: RO:0004024 GO:0006879 ! disease disrupts intracellular iron ion homeostasis
+relationship: RO:0004024 GO:0006879 ! disease disrupts intracellular iron ion homeostasis
[Term]
id: MONDO:0001357
@@ -178974,8 +177848,8 @@ id: MONDO:0001531
name: blood coagulation disease
is_a: MONDO:0005570 ! hematologic disorder
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0007596 ! disease causes disruption of blood coagulation
-relationship: RO:0004024 GO:0007596 ! disease causes disruption of blood coagulation
+intersection_of: RO:0004024 GO:0007596 ! disease disrupts blood coagulation
+relationship: RO:0004024 GO:0007596 ! disease disrupts blood coagulation
[Term]
id: MONDO:0001535
@@ -180369,8 +179243,8 @@ id: MONDO:0002319
name: phosphorus metabolism disease
is_a: MONDO:0000226 ! mineral metabolism disease
intersection_of: MONDO:0000226 ! mineral metabolism disease
-intersection_of: RO:0004024 GO:0006793 ! disease causes disruption of phosphorus metabolic process
-relationship: RO:0004024 GO:0006793 ! disease causes disruption of phosphorus metabolic process
+intersection_of: RO:0004024 GO:0006793 ! disease disrupts phosphorus metabolic process
+relationship: RO:0004024 GO:0006793 ! disease disrupts phosphorus metabolic process
[Term]
id: MONDO:0002320
@@ -180897,8 +179771,8 @@ id: MONDO:0002525
name: inherited lipid metabolism disorder
is_a: MONDO:0019052 ! inborn errors of metabolism
intersection_of: MONDO:0019052 ! inborn errors of metabolism
-intersection_of: RO:0004024 GO:0006629 ! disease causes disruption of lipid metabolic process
-relationship: RO:0004024 GO:0006629 ! disease causes disruption of lipid metabolic process
+intersection_of: RO:0004024 GO:0006629 ! disease disrupts lipid metabolic process
+relationship: RO:0004024 GO:0006629 ! disease disrupts lipid metabolic process
[Term]
id: MONDO:0002529
@@ -181011,8 +179885,8 @@ name: demyelinating disease
is_a: MONDO:0005559 ! neurodegenerative disease
is_a: MONDO:0021147 ! disorder of development or morphogenesis
intersection_of: MONDO:0005559 ! neurodegenerative disease
-intersection_of: RO:0004024 GO:0043217 ! disease causes disruption of myelin maintenance
-relationship: RO:0004024 GO:0043217 ! disease causes disruption of myelin maintenance
+intersection_of: RO:0004024 GO:0043217 ! disease disrupts myelin maintenance
+relationship: RO:0004024 GO:0043217 ! disease disrupts myelin maintenance
[Term]
id: MONDO:0002564
@@ -181168,7 +180042,7 @@ is_a: MONDO:0019056 ! neuromuscular disease
is_a: MONDO:0024417 ! perceptual disorders
intersection_of: MONDO:0000001 ! disease
intersection_of: RO:0004026 UBERON:0001862 ! disease has location vestibular labyrinth
-relationship: RO:0004024 GO:0050957 ! disease causes disruption of equilibrioception
+relationship: RO:0004024 GO:0050957 ! disease disrupts equilibrioception
relationship: RO:0004026 UBERON:0001862 ! disease has location vestibular labyrinth
[Term]
@@ -181810,8 +180684,8 @@ id: MONDO:0002908
name: glucose metabolism disease
is_a: MONDO:0005066 ! metabolic disease
intersection_of: MONDO:0005066 ! metabolic disease
-intersection_of: RO:0004024 GO:0006006 ! disease causes disruption of glucose metabolic process
-relationship: RO:0004024 GO:0006006 ! disease causes disruption of glucose metabolic process
+intersection_of: RO:0004024 GO:0006006 ! disease disrupts glucose metabolic process
+relationship: RO:0004024 GO:0006006 ! disease disrupts glucose metabolic process
[Term]
id: MONDO:0002909
@@ -182721,14 +181595,6 @@ intersection_of: MONDO:0000001 ! disease
intersection_of: RO:0004026 UBERON:0001754 ! disease has location dental pulp
relationship: RO:0004026 UBERON:0001754 ! disease has location dental pulp
-[Term]
-id: MONDO:0003395
-name: testicular granulosa cell tumor
-is_a: MONDO:0003125 ! testicular sex cord-stromal neoplasm
-is_a: MONDO:0006036 ! granulosa cell tumor
-intersection_of: MONDO:0006036 ! granulosa cell tumor
-intersection_of: RO:0004026 UBERON:0000473 ! disease has location testis
-
[Term]
id: MONDO:0003403
name: testicular non-seminomatous germ cell cancer
@@ -185480,8 +184346,8 @@ relationship: RO:0004022 HP:0006476 ! disease arises from feature Abnormality of
id: MONDO:0005148
name: type 2 diabetes mellitus
is_a: MONDO:0005015 ! diabetes mellitus
-relationship: RO:0004024 GO:0030073 ! disease causes disruption of insulin secretion
-relationship: RO:0004024 GO:0044381 ! disease causes disruption of glucose import in response to insulin stimulus
+relationship: RO:0004024 GO:0030073 ! disease disrupts insulin secretion
+relationship: RO:0004024 GO:0044381 ! disease disrupts glucose import in response to insulin stimulus
relationship: RO:0004029 HP:0000855 ! disease has feature Insulin resistance
[Term]
@@ -185933,8 +184799,8 @@ name: erectile dysfunction
is_a: MONDO:0002036 ! penile disorder
is_a: MONDO:0002134 ! physiological sexual disorder
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0043084 ! disease causes disruption of penile erection
-relationship: RO:0004024 GO:0043084 ! disease causes disruption of penile erection
+intersection_of: RO:0004024 GO:0043084 ! disease disrupts penile erection
+relationship: RO:0004024 GO:0043084 ! disease disrupts penile erection
[Term]
id: MONDO:0005369
@@ -186297,8 +185163,8 @@ id: MONDO:0005557
name: calcium metabolic disease
is_a: MONDO:0000226 ! mineral metabolism disease
intersection_of: MONDO:0005066 ! metabolic disease
-intersection_of: RO:0004024 GO:0055074 ! disease causes disruption of calcium ion homeostasis
-relationship: RO:0004024 GO:0055074 ! disease causes disruption of calcium ion homeostasis
+intersection_of: RO:0004024 GO:0055074 ! disease disrupts calcium ion homeostasis
+relationship: RO:0004024 GO:0055074 ! disease disrupts calcium ion homeostasis
[Term]
id: MONDO:0005558
@@ -186373,15 +185239,6 @@ intersection_of: RO:0004027 UBERON:0000982 ! disease has inflammation site skele
relationship: RO:0004027 UBERON:0000982 ! disease has inflammation site skeletal joint
relationship: RO:0004029 HP:0002829 ! disease has feature Arthralgia
-[Term]
-id: MONDO:0005579
-name: epilepsy, idiopathic generalized
-is_a: MONDO:0005027 ! epilepsy
-is_a: MONDO:0100545 ! hereditary neurological disease
-is_a: MONDO:0700007 ! idiopathic disease
-intersection_of: MONDO:0005027 ! epilepsy
-intersection_of: RO:0000053 MONDO:0700005 ! bearer of idiopathic
-
[Term]
id: MONDO:0005580
name: esophageal squamous cell carcinoma
@@ -186938,15 +185795,6 @@ is_a: MONDO:0005606 ! tubular adenocarcinoma
intersection_of: MONDO:0005606 ! tubular adenocarcinoma
intersection_of: RO:0004026 UBERON:0000945 ! disease has location stomach
-[Term]
-id: MONDO:0006036
-name: granulosa cell tumor
-is_a: MONDO:0002082 ! endocrine gland neoplasm
-is_a: MONDO:0006055 ! sex cord-stromal tumor
-intersection_of: MONDO:0005070 ! neoplasm
-intersection_of: RO:0004026 CL:0000501 ! disease has location granulosa cell
-relationship: RO:0004026 CL:0000501 ! disease has location granulosa cell
-
[Term]
id: MONDO:0006040
name: lactic acidosis
@@ -188278,6 +187126,16 @@ intersection_of: RO:0004020 CL:0000542 ! disease has basis in dysfunction of lym
intersection_of: RO:0004026 UBERON:0000014 ! disease has location zone of skin
relationship: RO:0004020 CL:0000542 ! disease has basis in dysfunction of lymphocyte
+[Term]
+id: MONDO:0008720
+name: congenital isolated adrenocorticotropic hormone deficiency
+is_a: MONDO:0013099 ! combined pituitary hormone deficiencies, genetic form
+is_a: MONDO:0016553 ! isolated congenital hypogonadotropic hypogonadism
+intersection_of: MONDO:0019824 ! non-acquired pituitary hormone deficiency
+intersection_of: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+intersection_of: RO:0004021 GO:0051458 ! disease caused by disruption of corticotropin secretion
+relationship: RO:0004021 GO:0051458 ! disease caused by disruption of corticotropin secretion
+
[Term]
id: MONDO:0008734
name: adrenocortical carcinoma, hereditary
@@ -188510,15 +187368,6 @@ is_a: MONDO:0100545 ! hereditary neurological disease
intersection_of: MONDO:0005152 ! hypopituitarism
intersection_of: RO:0000053 MONDO:0021152 ! bearer of inherited
-[Term]
-id: MONDO:0014471
-name: mitochondrial proton-transporting ATP synthase complex deficiency
-comment: Consider splitting out nuclear type for OMIMPS
-is_a: MONDO:0000732 ! combined oxidative phosphorylation deficiency
-intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004020 GO:0005753 ! disease has basis in dysfunction of mitochondrial proton-transporting ATP synthase complex
-relationship: RO:0004020 GO:0005753 ! disease has basis in dysfunction of mitochondrial proton-transporting ATP synthase complex
-
[Term]
id: MONDO:0015062
name: gastric neuroendocrine tumor, well differentiated, low or intermediate grade
@@ -188781,6 +187630,14 @@ intersection_of: MONDO:0004993 ! carcinoma
intersection_of: RO:0004026 UBERON:0001728 ! disease has location nasopharynx
relationship: RO:0004030 UBERON:0001951 ! disease arises from alteration in structure epithelium of nasopharynx
+[Term]
+id: MONDO:0015494
+name: isolated dystonia
+is_a: MONDO:0044807 ! inherited dystonia
+intersection_of: MONDO:0003441 ! dystonic disorder
+intersection_of: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+relationship: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+
[Term]
id: MONDO:0015514
name: hereditary endocrine growth disease
@@ -189035,8 +187892,8 @@ id: MONDO:0016387
name: mitochondrial oxidative phosphorylation disorder
is_a: MONDO:0004069 ! inborn mitochondrial metabolism disorder
intersection_of: MONDO:0004069 ! inborn mitochondrial metabolism disorder
-intersection_of: RO:0004024 GO:0006119 ! disease causes disruption of oxidative phosphorylation
-relationship: RO:0004024 GO:0006119 ! disease causes disruption of oxidative phosphorylation
+intersection_of: RO:0004024 GO:0006119 ! disease disrupts oxidative phosphorylation
+relationship: RO:0004024 GO:0006119 ! disease disrupts oxidative phosphorylation
[Term]
id: MONDO:0016419
@@ -189048,6 +187905,15 @@ intersection_of: MONDO:0004989 ! breast carcinoma
intersection_of: RO:0000053 MONDO:0021152 ! bearer of inherited
relationship: RO:0004029 MONDO:0004989 ! disease has feature breast carcinoma
+[Term]
+id: MONDO:0016553
+name: isolated congenital hypogonadotropic hypogonadism
+is_a: MONDO:0015770 ! congenital hypogonadotropic hypogonadism
+intersection_of: MONDO:0015770 ! congenital hypogonadotropic hypogonadism
+intersection_of: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+relationship: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+relationship: RO:0000053 MONDO:0021140 ! bearer of congenital
+
[Term]
id: MONDO:0016593
name: acquired ataxia
@@ -189137,8 +188003,8 @@ id: MONDO:0016800
name: mitochondrial membrane transport disorder
is_a: MONDO:0004069 ! inborn mitochondrial metabolism disorder
intersection_of: MONDO:0004069 ! inborn mitochondrial metabolism disorder
-intersection_of: RO:0004024 GO:1990542 ! disease causes disruption of mitochondrial transmembrane transport
-relationship: RO:0004024 GO:1990542 ! disease causes disruption of mitochondrial transmembrane transport
+intersection_of: RO:0004024 GO:1990542 ! disease disrupts mitochondrial transmembrane transport
+relationship: RO:0004024 GO:1990542 ! disease disrupts mitochondrial transmembrane transport
[Term]
id: MONDO:0017014
@@ -189292,8 +188158,8 @@ id: MONDO:0017352
name: disorder of glutamine metabolism
is_a: MONDO:0019189 ! inborn disorder of amino acid and other organic acid metabolism
intersection_of: MONDO:0019189 ! inborn disorder of amino acid and other organic acid metabolism
-intersection_of: RO:0004024 GO:0006541 ! disease causes disruption of glutamine metabolic process
-relationship: RO:0004024 GO:0006541 ! disease causes disruption of glutamine metabolic process
+intersection_of: RO:0004024 GO:0006541 ! disease disrupts glutamine metabolic process
+relationship: RO:0004024 GO:0006541 ! disease disrupts glutamine metabolic process
[Term]
id: MONDO:0017355
@@ -189629,8 +188495,8 @@ name: dysostosis
comment: Reason of obsoletion: out of scope - MONDO:excludeHistoricalDisease. Term to consider: -
is_a: MONDO:0005497 ! bone development disease
intersection_of: MONDO:0005497 ! bone development disease
-intersection_of: RO:0004024 GO:0001503 ! disease causes disruption of ossification
-relationship: RO:0004024 GO:0001503 ! disease causes disruption of ossification
+intersection_of: RO:0004024 GO:0001503 ! disease disrupts ossification
+relationship: RO:0004024 GO:0001503 ! disease disrupts ossification
[Term]
id: MONDO:0018352
@@ -189865,8 +188731,6 @@ intersection_of: RO:0000053 MONDO:0021152 ! bearer of inherited
id: MONDO:0019053
name: peroxisomal disease
is_a: MONDO:0019052 ! inborn errors of metabolism
-is_a: MONDO:0100033 ! metabolic epilepsy
-is_a: MONDO:0100545 ! hereditary neurological disease
intersection_of: MONDO:0019052 ! inborn errors of metabolism
intersection_of: RO:0004020 GO:0005777 ! disease has basis in dysfunction of peroxisome
relationship: RO:0004020 GO:0005777 ! disease has basis in dysfunction of peroxisome
@@ -189876,8 +188740,8 @@ id: MONDO:0019056
name: neuromuscular disease
is_a: MONDO:0005071 ! nervous system disorder
intersection_of: MONDO:0005071 ! nervous system disorder
-intersection_of: RO:0004024 GO:0050905 ! disease causes disruption of neuromuscular process
-relationship: RO:0004024 GO:0050905 ! disease causes disruption of neuromuscular process
+intersection_of: RO:0004024 GO:0050905 ! disease disrupts neuromuscular process
+relationship: RO:0004024 GO:0050905 ! disease disrupts neuromuscular process
[Term]
id: MONDO:0019060
@@ -189939,8 +188803,8 @@ id: MONDO:0019189
name: inborn disorder of amino acid and other organic acid metabolism
is_a: MONDO:0019052 ! inborn errors of metabolism
intersection_of: MONDO:0019052 ! inborn errors of metabolism
-intersection_of: RO:0004024 GO:0006082 ! disease causes disruption of organic acid metabolic process
-relationship: RO:0004024 GO:0006082 ! disease causes disruption of organic acid metabolic process
+intersection_of: RO:0004024 GO:0006082 ! disease disrupts organic acid metabolic process
+relationship: RO:0004024 GO:0006082 ! disease disrupts organic acid metabolic process
[Term]
id: MONDO:0019210
@@ -190018,8 +188882,8 @@ name: glucose transport disorder
is_a: MONDO:0017706 ! disorder of carbohydrate transmembrane transport and absorption
is_a: MONDO:0045015 ! carbohydrate transport disease
intersection_of: MONDO:0019052 ! inborn errors of metabolism
-intersection_of: RO:0004021 GO:1904659 ! disease caused by disruption of glucose transmembrane transport
-relationship: RO:0004021 GO:1904659 ! disease caused by disruption of glucose transmembrane transport
+intersection_of: RO:0004021 GO:1904659 ! disease caused by disruption of D-glucose transmembrane transport
+relationship: RO:0004021 GO:1904659 ! disease caused by disruption of D-glucose transmembrane transport
[Term]
id: MONDO:0019228
@@ -190116,9 +188980,9 @@ id: MONDO:0019254
name: inborn disorder of purine or pyrimidine metabolism
is_a: MONDO:0019052 ! inborn errors of metabolism
intersection_of: MONDO:0019052 ! inborn errors of metabolism
-intersection_of: RO:0004024 GO:0009117 ! disease causes disruption of nucleotide metabolic process
+intersection_of: RO:0004024 GO:0009117 ! disease disrupts nucleotide metabolic process
relationship: RO:0004021 GO:0009117 ! disease caused by disruption of nucleotide metabolic process
-relationship: RO:0004024 GO:0009117 ! disease causes disruption of nucleotide metabolic process
+relationship: RO:0004024 GO:0009117 ! disease disrupts nucleotide metabolic process
[Term]
id: MONDO:0019256
@@ -190129,6 +188993,16 @@ intersection_of: MONDO:0019052 ! inborn errors of metabolism
intersection_of: RO:0004021 GO:0016125 ! disease caused by disruption of sterol metabolic process
relationship: RO:0004021 GO:0016125 ! disease caused by disruption of sterol metabolic process
+[Term]
+id: MONDO:0019284
+name: inherited isolated nail anomaly
+is_a: MONDO:0002884 ! nail disorder
+is_a: MONDO:0003847 ! hereditary disease
+intersection_of: MONDO:0002884 ! nail disorder
+intersection_of: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+intersection_of: RO:0000053 MONDO:0021152 ! bearer of inherited
+relationship: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+
[Term]
id: MONDO:0019288
name: skin pigmentation disorder
@@ -190635,8 +189509,8 @@ id: MONDO:0020598
name: malabsorption syndrome
is_a: MONDO:0005020 ! intestinal disorder
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0050892 ! disease causes disruption of intestinal absorption
-relationship: RO:0004024 GO:0050892 ! disease causes disruption of intestinal absorption
+intersection_of: RO:0004024 GO:0050892 ! disease disrupts intestinal absorption
+relationship: RO:0004024 GO:0050892 ! disease disrupts intestinal absorption
[Term]
id: MONDO:0020600
@@ -190770,8 +189644,8 @@ name: cartilage development disorder
is_a: MONDO:0005172 ! skeletal system disorder
is_a: MONDO:0021147 ! disorder of development or morphogenesis
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0051216 ! disease causes disruption of cartilage development
-relationship: RO:0004024 GO:0051216 ! disease causes disruption of cartilage development
+intersection_of: RO:0004024 GO:0051216 ! disease disrupts cartilage development
+relationship: RO:0004024 GO:0051216 ! disease disrupts cartilage development
relationship: RO:0004026 UBERON:0002418 ! disease has location cartilage tissue
[Term]
@@ -191031,8 +189905,8 @@ name: vision disorder
is_a: MONDO:0024417 ! perceptual disorders
is_a: MONDO:0024458 ! disorder of visual system
intersection_of: MONDO:0700096 ! human disease
-intersection_of: RO:0004024 GO:0007601 ! disease causes disruption of visual perception
-relationship: RO:0004024 GO:0007601 ! disease causes disruption of visual perception
+intersection_of: RO:0004024 GO:0007601 ! disease disrupts visual perception
+relationship: RO:0004024 GO:0007601 ! disease disrupts visual perception
[Term]
id: MONDO:0021085
@@ -191192,6 +190066,11 @@ id: MONDO:0021127
name: has a syndromic presentation
is_a: MONDO:0021126 ! syndromic or isolated
+[Term]
+id: MONDO:0021128
+name: has an isolated presentation
+is_a: MONDO:0021126 ! syndromic or isolated
+
[Term]
id: MONDO:0021130
name: disorder of sphingolipid biosynthesis
@@ -191256,8 +190135,8 @@ id: MONDO:0021147
name: disorder of development or morphogenesis
is_a: MONDO:0700096 ! human disease
intersection_of: MONDO:0700096 ! human disease
-intersection_of: RO:0004024 GO:0032502 ! disease causes disruption of developmental process
-relationship: RO:0004024 GO:0032502 ! disease causes disruption of developmental process
+intersection_of: RO:0004024 GO:0032502 ! disease disrupts developmental process
+relationship: RO:0004024 GO:0032502 ! disease disrupts developmental process
[Term]
id: MONDO:0021148
@@ -191326,7 +190205,7 @@ name: inflammatory disease
is_a: MONDO:0700096 ! human disease
intersection_of: MONDO:0700096 ! human disease
intersection_of: RO:0004027 UBERON:0000061 ! disease has inflammation site anatomical structure
-relationship: RO:0004024 GO:0006954 ! disease causes disruption of inflammatory response
+relationship: RO:0004024 GO:0006954 ! disease disrupts inflammatory response
relationship: RO:0004027 UBERON:0000061 ! disease has inflammation site anatomical structure
[Term]
@@ -191362,7 +190241,7 @@ is_a: MONDO:0005066 ! metabolic disease
intersection_of: MONDO:0005066 ! metabolic disease
intersection_of: disease_has_major_feature HP:0003077 ! Hyperlipidemia
relationship: disease_has_major_feature HP:0003077 ! Hyperlipidemia
-relationship: RO:0004024 GO:0006629 ! disease causes disruption of lipid metabolic process
+relationship: RO:0004024 GO:0006629 ! disease disrupts lipid metabolic process
[Term]
id: MONDO:0021190
@@ -193181,8 +192060,8 @@ name: hearing disorder
is_a: MONDO:0002409 ! auditory system disorder
is_a: MONDO:0024417 ! perceptual disorders
intersection_of: MONDO:0700096 ! human disease
-intersection_of: RO:0004024 GO:0007605 ! disease causes disruption of sensory perception of sound
-relationship: RO:0004024 GO:0007605 ! disease causes disruption of sensory perception of sound
+intersection_of: RO:0004024 GO:0007605 ! disease disrupts sensory perception of sound
+relationship: RO:0004024 GO:0007605 ! disease disrupts sensory perception of sound
[Term]
id: MONDO:0021950
@@ -193340,14 +192219,6 @@ intersection_of: MONDO:0005550 ! infectious disease
intersection_of: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses
intersection_of: RO:0004027 UBERON:0002407 ! disease has inflammation site pericardium
-[Term]
-id: MONDO:0023283
-name: ovarian granulosa cell tumor
-is_a: MONDO:0006036 ! granulosa cell tumor
-is_a: MONDO:0021657 ! ovarian sex cord-stromal tumor
-intersection_of: MONDO:0006036 ! granulosa cell tumor
-intersection_of: RO:0004026 UBERON:0000992 ! disease has location ovary
-
[Term]
id: MONDO:0023305
name: heavy metal poisoning
@@ -193739,8 +192610,8 @@ name: perceptual disorders
is_a: MONDO:0002025 ! psychiatric disorder
is_a: MONDO:0005071 ! nervous system disorder
intersection_of: MONDO:0700096 ! human disease
-intersection_of: RO:0004024 GO:0007600 ! disease causes disruption of sensory perception
-relationship: RO:0004024 GO:0007600 ! disease causes disruption of sensory perception
+intersection_of: RO:0004024 GO:0007600 ! disease disrupts sensory perception
+relationship: RO:0004024 GO:0007600 ! disease disrupts sensory perception
[Term]
id: MONDO:0024422
@@ -194026,17 +192897,17 @@ id: MONDO:0024627
name: phagocytic cell dysfunction
is_a: MONDO:0005046 ! immune system disorder
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0006909 ! disease causes disruption of phagocytosis
+intersection_of: RO:0004024 GO:0006909 ! disease disrupts phagocytosis
relationship: RO:0004020 CL:0000234 ! disease has basis in dysfunction of phagocyte
-relationship: RO:0004024 GO:0006909 ! disease causes disruption of phagocytosis
+relationship: RO:0004024 GO:0006909 ! disease disrupts phagocytosis
[Term]
id: MONDO:0024630
name: defective phagocytic cell chemotaxis
is_a: MONDO:0024627 ! phagocytic cell dysfunction
intersection_of: MONDO:0024627 ! phagocytic cell dysfunction
-intersection_of: RO:0004024 GO:0006935 ! disease causes disruption of chemotaxis
-relationship: RO:0004024 GO:0006935 ! disease causes disruption of chemotaxis
+intersection_of: RO:0004024 GO:0006935 ! disease disrupts chemotaxis
+relationship: RO:0004024 GO:0006935 ! disease disrupts chemotaxis
[Term]
id: MONDO:0024633
@@ -194494,8 +193365,8 @@ name: inherited fatty acid metabolism disorder
is_a: MONDO:0002525 ! inherited lipid metabolism disorder
is_a: MONDO:0019189 ! inborn disorder of amino acid and other organic acid metabolism
intersection_of: MONDO:0019052 ! inborn errors of metabolism
-intersection_of: RO:0004024 GO:0006631 ! disease causes disruption of fatty acid metabolic process
-relationship: RO:0004024 GO:0006631 ! disease causes disruption of fatty acid metabolic process
+intersection_of: RO:0004024 GO:0006631 ! disease disrupts fatty acid metabolic process
+relationship: RO:0004024 GO:0006631 ! disease disrupts fatty acid metabolic process
[Term]
id: MONDO:0037870
@@ -194607,8 +193478,8 @@ id: MONDO:0041261
name: disorder of acid-base balance
is_a: MONDO:0005066 ! metabolic disease
intersection_of: MONDO:0005066 ! metabolic disease
-intersection_of: RO:0004024 GO:0006885 ! disease causes disruption of regulation of pH
-relationship: RO:0004024 GO:0006885 ! disease causes disruption of regulation of pH
+intersection_of: RO:0004024 GO:0006885 ! disease disrupts regulation of pH
+relationship: RO:0004024 GO:0006885 ! disease disrupts regulation of pH
[Term]
id: MONDO:0041284
@@ -194713,6 +193584,18 @@ id: MONDO:0042976
name: vitamin B deficiency
is_a: MONDO:0024298 ! vitamin deficiency disorder
+[Term]
+id: MONDO:0043137
+name: isolated microcephaly
+is_a: MONDO:0001149 ! microcephaly
+intersection_of: MONDO:0000001 ! disease
+intersection_of: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+intersection_of: RO:0004026 UBERON:0000033 ! disease has location head
+intersection_of: RO:0004029 HP:0000252 ! disease has feature Microcephaly
+relationship: RO:0000053 MONDO:0021128 ! bearer of has an isolated presentation
+relationship: RO:0004026 UBERON:0000033 ! disease has location head
+relationship: RO:0004029 HP:0000252 ! disease has feature Microcephaly
+
[Term]
id: MONDO:0043218
name: neurovascular disorder
@@ -194786,8 +193669,8 @@ id: MONDO:0043862
name: voice disorders
is_a: MONDO:0004382 ! laryngeal disorder
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0071625 ! disease causes disruption of vocalization behavior
-relationship: RO:0004024 GO:0071625 ! disease causes disruption of vocalization behavior
+intersection_of: RO:0004024 GO:0071625 ! disease disrupts vocalization behavior
+relationship: RO:0004024 GO:0071625 ! disease disrupts vocalization behavior
[Term]
id: MONDO:0043885
@@ -195195,8 +194078,8 @@ name: keratinization disease
is_a: MONDO:0002051 ! integumentary system disorder
is_a: MONDO:0021147 ! disorder of development or morphogenesis
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0031424 ! disease causes disruption of keratinization
-relationship: RO:0004024 GO:0031424 ! disease causes disruption of keratinization
+intersection_of: RO:0004024 GO:0031424 ! disease disrupts keratinization
+relationship: RO:0004024 GO:0031424 ! disease disrupts keratinization
[Term]
id: MONDO:0045012
@@ -195262,8 +194145,8 @@ name: lactation disease
is_a: MONDO:0002657 ! breast disorder
is_a: MONDO:0021147 ! disorder of development or morphogenesis
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0007595 ! disease causes disruption of lactation
-relationship: RO:0004024 GO:0007595 ! disease causes disruption of lactation
+intersection_of: RO:0004024 GO:0007595 ! disease disrupts lactation
+relationship: RO:0004024 GO:0007595 ! disease disrupts lactation
[Term]
id: MONDO:0045020
@@ -195287,12 +194170,12 @@ id: MONDO:0045024
name: cancer or benign tumor
is_a: MONDO:0700096 ! human disease
intersection_of: MONDO:0700096 ! human disease
-intersection_of: RO:0004024 GO:0008283 ! disease causes disruption of cell population proliferation
+intersection_of: RO:0004024 GO:0008283 ! disease disrupts cell population proliferation
union_of: MONDO:0005043 ! hyperplasia
union_of: MONDO:0021074 ! precancerous condition
union_of: MONDO:0023370 ! neoplastic disease or syndrome
union_of: MONDO:0045054 ! cancer-related condition
-relationship: RO:0004024 GO:0008283 ! disease causes disruption of cell population proliferation
+relationship: RO:0004024 GO:0008283 ! disease disrupts cell population proliferation
[Term]
id: MONDO:0045034
@@ -195472,11 +194355,6 @@ def: "An epilepsy syndrome that has an onset during the adolescent or adult stag
comment: This type of grouping class represents an older way of classifying diseases, and represented here https://www.epilepsydiagnosis.org/index.html. Reason of obsoletion: out of scope - MONDO:excludeHistoricalDisease. Term to consider: -
is_a: MONDO:0015650 ! epilepsy syndrome
-[Term]
-id: MONDO:0100033
-name: metabolic epilepsy
-is_a: MONDO:0005027 ! epilepsy
-
[Term]
id: MONDO:0100035
name: structural epilepsy
@@ -195505,8 +194383,8 @@ id: MONDO:0100081
name: sleep disorder
is_a: MONDO:0005071 ! nervous system disorder
intersection_of: MONDO:0000001 ! disease
-intersection_of: RO:0004024 GO:0030431 ! disease causes disruption of sleep
-relationship: RO:0004024 GO:0030431 ! disease causes disruption of sleep
+intersection_of: RO:0004024 GO:0030431 ! disease disrupts sleep
+relationship: RO:0004024 GO:0030431 ! disease disrupts sleep
[Term]
id: MONDO:0100085
@@ -195638,6 +194516,14 @@ id: MONDO:0100473
name: disorder of peptide and amine metabolism
is_a: MONDO:0019052 ! inborn errors of metabolism
+[Term]
+id: MONDO:0100500
+name: Mendelian neurodevelopmental disorder
+is_a: MONDO:0100545 ! hereditary neurological disease
+is_a: MONDO:0700092 ! neurodevelopmental disorder
+intersection_of: MONDO:0700092 ! neurodevelopmental disorder
+intersection_of: RO:0000053 MONDO:0021152 ! bearer of inherited
+
[Term]
id: MONDO:0100504
name: fungal infection of the toenail
@@ -195735,6 +194621,11 @@ intersection_of: disease_has_major_feature HP:0012531 ! Pain
relationship: BFO:0000054 GO:0019233 ! realized in sensory perception of pain
relationship: disease_has_major_feature HP:0012531 ! Pain
+[Term]
+id: MONDO:0700092
+name: neurodevelopmental disorder
+is_a: MONDO:0005071 ! nervous system disorder
+
[Term]
id: MONDO:0700096
name: human disease
@@ -198359,6 +197250,11 @@ id: NCBITaxon:4896
name: Schizosaccharomyces pombe
is_a: NCBITaxon:4895 ! Schizosaccharomyces
+[Term]
+id: NCBITaxon:4899
+name: Schizosaccharomyces octosporus
+is_a: NCBITaxon:4895 ! Schizosaccharomyces
+
[Term]
id: NCBITaxon:4930
name: Saccharomyces
@@ -210388,14 +209284,14 @@ relationship: RO:0000052 UBERON:0010890 ! characteristic of pelvic complex muscl
[Term]
id: OBA:0002874
-name: mitochondrial respirasome rate
-def: "The rate of a mitochondrial respirasome." [AUTO:patterns/patterns/entity_attribute]
-synonym: "rate of mitochondrial respirasome" EXACT [AUTO:patterns/patterns/entity_attribute]
-is_a: OBA:1000201 ! mitochondrial respirasome quality
+name: respiratory chain complex rate
+def: "The rate of a respiratory chain complex." [AUTO:patterns/patterns/entity_attribute]
+synonym: "rate of respiratory chain complex" EXACT [AUTO:patterns/patterns/entity_attribute]
+is_a: OBA:1000201 ! respiratory chain complex quality
is_a: PATO:0000161 ! rate
intersection_of: PATO:0000161 ! rate
-intersection_of: RO:0000052 GO:0005746 ! characteristic of mitochondrial respirasome
-relationship: RO:0000052 GO:0005746 ! characteristic of mitochondrial respirasome
+intersection_of: RO:0000052 GO:0098803 ! characteristic of respiratory chain complex
+relationship: RO:0000052 GO:0098803 ! characteristic of respiratory chain complex
[Term]
id: OBA:0002875
@@ -215170,16 +214066,14 @@ intersection_of: RO:0000052 UBERON:0003635 ! characteristic of pedal digit 5
[Term]
id: OBA:0003279
-name: mitochondrial proton-transporting ATP synthase complex rate
-def: "The rate of a mitochondrial proton-transporting ATP synthase complex." [AUTO:patterns/patterns/entity_attribute]
-synonym: "rate of mitochondrial proton-transporting ATP synthase complex" EXACT [AUTO:patterns/patterns/entity_attribute]
-is_a: OBA:1000076 ! attribute of cell
-is_a: OBA:1000078 ! attribute of organelle
+name: proton-transporting ATP synthase complex rate
+def: "The rate of a proton-transporting ATP synthase complex." [AUTO:patterns/patterns/entity_attribute]
+synonym: "rate of proton-transporting ATP synthase complex" EXACT [AUTO:patterns/patterns/entity_attribute]
+is_a: OBA:0002874 ! respiratory chain complex rate
is_a: OBA:1000090 ! membrane quality
-is_a: PATO:0000161 ! rate
intersection_of: PATO:0000161 ! rate
-intersection_of: RO:0000052 GO:0005753 ! characteristic of mitochondrial proton-transporting ATP synthase complex
-relationship: RO:0000052 GO:0005753 ! characteristic of mitochondrial proton-transporting ATP synthase complex
+intersection_of: RO:0000052 GO:0045259 ! characteristic of proton-transporting ATP synthase complex
+relationship: RO:0000052 GO:0045259 ! characteristic of proton-transporting ATP synthase complex
[Term]
id: OBA:0003280
@@ -222211,25 +221105,25 @@ relationship: RO:0000052 UBERON:0001103 ! characteristic of diaphragm
[Term]
id: OBA:0003886
-name: glucose import rate
-def: "The rate of a glucose import." [AUTO:patterns/patterns/entity_attribute]
-synonym: "rate of glucose import" EXACT [AUTO:patterns/patterns/entity_attribute]
+name: D-glucose import rate
+def: "The rate of a D-glucose import." [AUTO:patterns/patterns/entity_attribute]
+synonym: "rate of D-glucose import" EXACT [AUTO:patterns/patterns/entity_attribute]
is_a: OBA:0100002 ! biological process attribute
is_a: PATO:0000161 ! rate
intersection_of: PATO:0000161 ! rate
-intersection_of: RO:0000052 GO:0046323 ! characteristic of glucose import
-relationship: RO:0000052 GO:0046323 ! characteristic of glucose import
+intersection_of: RO:0000052 GO:0046323 ! characteristic of D-glucose import
+relationship: RO:0000052 GO:0046323 ! characteristic of D-glucose import
[Term]
id: OBA:0003887
-name: glucose import amount
-def: "The amount of a glucose import." [AUTO:patterns/patterns/entity_attribute]
-synonym: "amount of glucose import" EXACT [AUTO:patterns/patterns/entity_attribute]
+name: D-glucose import amount
+def: "The amount of a D-glucose import." [AUTO:patterns/patterns/entity_attribute]
+synonym: "amount of D-glucose import" EXACT [AUTO:patterns/patterns/entity_attribute]
is_a: OBA:0100002 ! biological process attribute
is_a: PATO:0000070 ! amount
intersection_of: PATO:0000070 ! amount
-intersection_of: RO:0000052 GO:0046323 ! characteristic of glucose import
-relationship: RO:0000052 GO:0046323 ! characteristic of glucose import
+intersection_of: RO:0000052 GO:0046323 ! characteristic of D-glucose import
+relationship: RO:0000052 GO:0046323 ! characteristic of D-glucose import
[Term]
id: OBA:0003888
@@ -229273,6 +228167,7 @@ name: granulosa cell morphology
def: "The morphology of a granulosa cell." [obo:oba/patterns/entity_attribute_part_of]
synonym: "morphology of granulosa cell" EXACT [obo:oba/patterns/entity_attribute_part_of]
is_a: OBA:1001065 ! cell morphology trait
+is_a: OBA:VT0001131 ! ovarian follicle morphology trait
intersection_of: PATO:0000051 ! morphology
intersection_of: RO:0002314 CL:0000501 ! characteristic of part of granulosa cell
relationship: RO:0002314 CL:0000501 ! characteristic of part of granulosa cell
@@ -240026,7 +238921,7 @@ id: OBA:0005485
name: lipoprotein lipase activity rate
def: "The rate of a lipoprotein lipase activity." [AUTO:patterns/patterns/entity_attribute]
synonym: "rate of lipoprotein lipase activity" EXACT [AUTO:patterns/patterns/entity_attribute]
-is_a: OBA:0005486 ! triglyceride lipase activity rate
+is_a: OBA:0005486 ! triacylglycerol lipase activity rate
is_a: OBA:1000849 ! lipoprotein lipase activity quality
intersection_of: PATO:0000161 ! rate
intersection_of: RO:0000052 GO:0004465 ! characteristic of lipoprotein lipase activity
@@ -240034,14 +238929,14 @@ relationship: RO:0000052 GO:0004465 ! characteristic of lipoprotein lipase activ
[Term]
id: OBA:0005486
-name: triglyceride lipase activity rate
-def: "The rate of a triglyceride lipase activity." [AUTO:patterns/patterns/entity_attribute]
-synonym: "rate of triglyceride lipase activity" EXACT [AUTO:patterns/patterns/entity_attribute]
-is_a: OBA:1000909 ! triglyceride lipase activity quality
+name: triacylglycerol lipase activity rate
+def: "The rate of a triacylglycerol lipase activity." [AUTO:patterns/patterns/entity_attribute]
+synonym: "rate of triacylglycerol lipase activity" EXACT [AUTO:patterns/patterns/entity_attribute]
+is_a: OBA:1000909 ! triacylglycerol lipase activity quality
is_a: PATO:0000161 ! rate
intersection_of: PATO:0000161 ! rate
-intersection_of: RO:0000052 GO:0004806 ! characteristic of triglyceride lipase activity
-relationship: RO:0000052 GO:0004806 ! characteristic of triglyceride lipase activity
+intersection_of: RO:0000052 GO:0004806 ! characteristic of triacylglycerol lipase activity
+relationship: RO:0000052 GO:0004806 ! characteristic of triacylglycerol lipase activity
[Term]
id: OBA:0005487
@@ -245933,14 +244828,14 @@ relationship: RO:0000052 GO:0004104 ! characteristic of cholinesterase activity
[Term]
id: OBA:0006016
-name: L-tyrosine aminotransferase activity rate
-def: "The rate of a L-tyrosine aminotransferase activity." [AUTO:patterns/patterns/entity_attribute]
-synonym: "rate of L-tyrosine aminotransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute]
-is_a: OBA:1000847 ! L-tyrosine aminotransferase activity quality
+name: L-tyrosine-2-oxoglutarate transaminase activity rate
+def: "The rate of a L-tyrosine-2-oxoglutarate transaminase activity." [AUTO:patterns/patterns/entity_attribute]
+synonym: "rate of L-tyrosine-2-oxoglutarate transaminase activity" EXACT [AUTO:patterns/patterns/entity_attribute]
+is_a: OBA:1000847 ! L-tyrosine-2-oxoglutarate transaminase activity quality
is_a: PATO:0000161 ! rate
intersection_of: PATO:0000161 ! rate
-intersection_of: RO:0000052 GO:0070547 ! characteristic of L-tyrosine aminotransferase activity
-relationship: RO:0000052 GO:0070547 ! characteristic of L-tyrosine aminotransferase activity
+intersection_of: RO:0000052 GO:0004838 ! characteristic of L-tyrosine-2-oxoglutarate transaminase activity
+relationship: RO:0000052 GO:0004838 ! characteristic of L-tyrosine-2-oxoglutarate transaminase activity
[Term]
id: OBA:0006017
@@ -249070,15 +247965,13 @@ relationship: RO:0002314 UBERON:0001653 ! characteristic of part of facial vein
[Term]
id: OBA:1000201
-name: mitochondrial respirasome quality
-def: "The quality of a mitochondrial respirasome." [obo:oba/patterns/entity_attribute_part_of]
-synonym: "quality of mitochondrial respirasome" EXACT [obo:oba/patterns/entity_attribute_part_of]
-is_a: OBA:1000076 ! attribute of cell
-is_a: OBA:1000078 ! attribute of organelle
-is_a: OBA:1000090 ! membrane quality
+name: respiratory chain complex quality
+def: "The quality of a respiratory chain complex." [obo:oba/patterns/entity_attribute_part_of]
+synonym: "quality of respiratory chain complex" EXACT [obo:oba/patterns/entity_attribute_part_of]
+is_a: OBA:0100001 ! cellular component attribute
intersection_of: PATO:0000001 ! quality
-intersection_of: RO:0002314 GO:0005746 ! characteristic of part of mitochondrial respirasome
-relationship: RO:0002314 GO:0005746 ! characteristic of part of mitochondrial respirasome
+intersection_of: RO:0002314 GO:0098803 ! characteristic of part of respiratory chain complex
+relationship: RO:0002314 GO:0098803 ! characteristic of part of respiratory chain complex
[Term]
id: OBA:1000202
@@ -253966,13 +252859,13 @@ relationship: RO:0002314 NBO:0001915 ! characteristic of part of cocaine consump
[Term]
id: OBA:1000680
-name: hormone-sensitive lipase activity quality
-def: "The quality of a hormone-sensitive lipase activity." [obo:oba/patterns/entity_attribute_part_of]
-synonym: "quality of hormone-sensitive lipase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
+name: diacylglycerol lipase activity quality
+def: "The quality of a diacylglycerol lipase activity." [obo:oba/patterns/entity_attribute_part_of]
+synonym: "quality of diacylglycerol lipase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait
intersection_of: PATO:0000001 ! quality
-intersection_of: RO:0002314 GO:0033878 ! characteristic of part of hormone-sensitive lipase activity
-relationship: RO:0002314 GO:0033878 ! characteristic of part of hormone-sensitive lipase activity
+intersection_of: RO:0002314 GO:0120516 ! characteristic of part of diacylglycerol lipase activity
+relationship: RO:0002314 GO:0120516 ! characteristic of part of diacylglycerol lipase activity
[Term]
id: OBA:1000681
@@ -255644,13 +254537,13 @@ is_obsolete: true
[Term]
id: OBA:1000847
-name: L-tyrosine aminotransferase activity quality
-def: "The quality of a L-tyrosine aminotransferase activity." [obo:oba/patterns/entity_attribute_part_of]
-synonym: "quality of L-tyrosine aminotransferase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
+name: L-tyrosine-2-oxoglutarate transaminase activity quality
+def: "The quality of a L-tyrosine-2-oxoglutarate transaminase activity." [obo:oba/patterns/entity_attribute_part_of]
+synonym: "quality of L-tyrosine-2-oxoglutarate transaminase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait
intersection_of: PATO:0000001 ! quality
-intersection_of: RO:0002314 GO:0070547 ! characteristic of part of L-tyrosine aminotransferase activity
-relationship: RO:0002314 GO:0070547 ! characteristic of part of L-tyrosine aminotransferase activity
+intersection_of: RO:0002314 GO:0004838 ! characteristic of part of L-tyrosine-2-oxoglutarate transaminase activity
+relationship: RO:0002314 GO:0004838 ! characteristic of part of L-tyrosine-2-oxoglutarate transaminase activity
[Term]
id: OBA:1000848
@@ -255667,7 +254560,7 @@ id: OBA:1000849
name: lipoprotein lipase activity quality
def: "The quality of a lipoprotein lipase activity." [obo:oba/patterns/entity_attribute_part_of]
synonym: "quality of lipoprotein lipase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
-is_a: OBA:1000909 ! triglyceride lipase activity quality
+is_a: OBA:1000909 ! triacylglycerol lipase activity quality
intersection_of: PATO:0000001 ! quality
intersection_of: RO:0002314 GO:0004465 ! characteristic of part of lipoprotein lipase activity
relationship: RO:0002314 GO:0004465 ! characteristic of part of lipoprotein lipase activity
@@ -256267,13 +255160,13 @@ relationship: RO:0002314 UBERON:0001992 ! characteristic of part of papillary la
[Term]
id: OBA:1000909
-name: triglyceride lipase activity quality
-def: "The quality of a triglyceride lipase activity." [obo:oba/patterns/entity_attribute_part_of]
-synonym: "quality of triglyceride lipase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
+name: triacylglycerol lipase activity quality
+def: "The quality of a triacylglycerol lipase activity." [obo:oba/patterns/entity_attribute_part_of]
+synonym: "quality of triacylglycerol lipase activity" EXACT [obo:oba/patterns/entity_attribute_part_of]
is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait
intersection_of: PATO:0000001 ! quality
-intersection_of: RO:0002314 GO:0004806 ! characteristic of part of triglyceride lipase activity
-relationship: RO:0002314 GO:0004806 ! characteristic of part of triglyceride lipase activity
+intersection_of: RO:0002314 GO:0004806 ! characteristic of part of triacylglycerol lipase activity
+relationship: RO:0002314 GO:0004806 ! characteristic of part of triacylglycerol lipase activity
[Term]
id: OBA:1000910
@@ -321158,6 +320051,35 @@ xref: PMID:34857772
is_a: OBA:VT0005416 ! blood protein amount
property_value: terms:contributor "https://orcid.org/0000-0001-6757-4744" xsd:string
+[Term]
+id: OBA:2051963
+name: trait in response to gabapentin
+def: "A trait that affects the response to a stimulus with gabapentin." []
+synonym: "response to gabapentin trait" EXACT []
+is_a: OBA:2040050 ! trait in response to anticonvulsant
+is_a: OBA:2040063 ! trait in response to calcium channel blocker
+property_value: terms:contributor "https://orcid.org/0000-0001-6757-4744" xsd:string
+
+[Term]
+id: OBA:2051964
+name: age of onset of isolated dystonia
+def: "The age at which isolated dystonia manifestations first appear." []
+synonym: "age at onset of isolated dystonia" EXACT []
+synonym: "age isolated dystonia symptoms begin" EXACT []
+is_a: OBA:2020000 ! age of onset of disease
+intersection_of: HP:0003674 ! Onset
+intersection_of: RO:0000052 MONDO:0015494 ! characteristic of isolated dystonia
+relationship: RO:0000052 MONDO:0015494 ! characteristic of isolated dystonia
+
+[Term]
+id: OBA:2051965
+name: amount of apolipoprotein(a) in blood
+def: "The amount of a apolipoprotein(a) when measured in blood." [AUTO:patterns/patterns/entity_attribute_location]
+synonym: "blood apolipoprotein(a) amount" EXACT [AUTO:patterns/patterns/entity_attribute_location]
+xref: PMID:36959364
+is_a: OBA:VT0005416 ! blood protein amount
+property_value: terms:contributor "https://orcid.org/0000-0001-6757-4744" xsd:string
+
[Term]
id: OBA:2060000
name: aggressive behavior towards inanimate objects rate
@@ -347828,6 +346750,11 @@ id: PATO:0001407
name: mononucleate
is_a: PATO:0002505 ! nucleated
+[Term]
+id: PATO:0001408
+name: ciliated
+is_a: PATO:0001396 ! cellular quality
+
[Term]
id: PATO:0001410
name: striated
@@ -349341,6 +348268,11 @@ name: cell morphology
comment: Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts.
is_a: PATO:0000051 ! morphology
+[Term]
+id: PATO:0010007
+name: multiciliated
+is_a: PATO:0001408 ! ciliated
+
[Term]
id: PATO:0015001
name: absence due to degeneration
@@ -372001,6 +370933,14 @@ is_a: CHEBI:36080 ! protein
relationship: has_gene_template SO:0000704 ! gene
relationship: RO:0002353 GO:0006412 ! output of translation
+[Term]
+id: PR:000009888
+name: apolipoprotein(a)
+comment: Category=gene.
+is_a: CHEBI:36080 ! protein
+relationship: has_gene_template SO:0000704 ! gene
+relationship: RO:0002353 GO:0006412 ! output of translation
+
[Term]
id: PR:000009891
name: lysophosphatidylcholine acyltransferase 2
@@ -398523,6 +397463,15 @@ intersection_of: PR:000009850 ! protein ERGIC-53
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: lacks_part SO:0000418 ! signal_peptide
+[Term]
+id: PR:000020482
+name: apolipoprotein(a), signal peptide removed form
+comment: Category=modification.
+is_a: PR:000009888 ! apolipoprotein(a)
+intersection_of: PR:000009888 ! apolipoprotein(a)
+intersection_of: lacks_part SO:0000418 ! signal_peptide
+relationship: lacks_part SO:0000418 ! signal_peptide
+
[Term]
id: PR:000020484
name: lipoprotein lipase, signal peptide removed form
@@ -416994,6 +415943,15 @@ intersection_of: PR:P58215 ! lysyl oxidase homolog 3 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: lacks_part SO:0000418 ! signal_peptide
+[Term]
+id: PR:000048235
+name: apolipoprotein(a), signal peptide removed form (human)
+comment: Category=organism-modification.
+is_a: PR:000020482 ! apolipoprotein(a), signal peptide removed form
+is_a: PR:P08519 ! apolipoprotein(a) (human)
+intersection_of: PR:P08519 ! apolipoprotein(a) (human)
+intersection_of: lacks_part SO:0000418 ! signal_peptide
+
[Term]
id: PR:000048239
name: lipoprotein lipase, signal peptide removed form (human)
@@ -437690,6 +436648,15 @@ is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000009127 ! integrin alpha-IIb
intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens
+[Term]
+id: PR:P08519
+name: apolipoprotein(a) (human)
+comment: Category=organism-gene.
+is_a: PR:000009888 ! apolipoprotein(a)
+is_a: PR:000029067 ! Homo sapiens protein
+intersection_of: PR:000009888 ! apolipoprotein(a)
+intersection_of: RO:0002160 NCBITaxon:9606 ! only in taxon Homo sapiens
+
[Term]
id: PR:P08551
name: neurofilament light polypeptide (mouse)
@@ -587421,7 +586388,7 @@ def: "A relation that holds between the disease and a process where the physical
comment: Editor note: TODO property chain: disease_has_location <- dhbido o occurs_in
range: BFO:0000015 ! process
is_a: RO:0004019 ! disease has basis in
-is_a: RO:0004024 ! disease causes disruption of
+is_a: RO:0004024 ! disease disrupts
transitive_over: BFO:0000050 ! part of
[Typedef]
diff --git a/patterns/definitions.owl b/patterns/definitions.owl
index d1c59a4c..5052e6fd 100644
--- a/patterns/definitions.owl
+++ b/patterns/definitions.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=)
Ontology(
-
-Annotation(owl:versionInfo "2024-09-12")
+
+Annotation(owl:versionInfo "2024-11-26")
Declaration(Class())
Declaration(Class())
@@ -309,6 +309,7 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -942,6 +943,7 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -952,8 +954,6 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
-Declaration(Class())
-Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -1243,7 +1243,6 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
-Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -1337,6 +1336,7 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -1467,7 +1467,6 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
-Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -1520,9 +1519,11 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -1573,6 +1574,7 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -14193,6 +14195,9 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
+Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -19353,6 +19358,7 @@ Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
+Declaration(Class())
Declaration(Class())
Declaration(Class())
Declaration(Class())
@@ -31781,12 +31787,12 @@ AnnotationAssertion(Annotation( "pelvic complex muscle size")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
-# Class: (mitochondrial respirasome rate)
+# Class: (respiratory chain complex rate)
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a mitochondrial respirasome.")
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of mitochondrial respirasome")
-AnnotationAssertion(rdfs:label "mitochondrial respirasome rate")
-EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a respiratory chain complex.")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of respiratory chain complex")
+AnnotationAssertion(rdfs:label "respiratory chain complex rate")
+EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
# Class: (muscle of neck size)
@@ -34616,12 +34622,12 @@ AnnotationAssertion(Annotation( "pedal digit 5 length")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
-# Class: (mitochondrial proton-transporting ATP synthase complex rate)
+# Class: (proton-transporting ATP synthase complex rate)
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a mitochondrial proton-transporting ATP synthase complex.")
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of mitochondrial proton-transporting ATP synthase complex")
-AnnotationAssertion(rdfs:label "mitochondrial proton-transporting ATP synthase complex rate")
-EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a proton-transporting ATP synthase complex.")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of proton-transporting ATP synthase complex")
+AnnotationAssertion(rdfs:label "proton-transporting ATP synthase complex rate")
+EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
# Class: (pedal digit 1 displaced)
@@ -38816,18 +38822,18 @@ AnnotationAssertion(Annotation( "diaphragm position")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
-# Class: (glucose import rate)
+# Class: (D-glucose import rate)
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a glucose import.")
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of glucose import")
-AnnotationAssertion(rdfs:label "glucose import rate")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a D-glucose import.")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of D-glucose import")
+AnnotationAssertion(rdfs:label "D-glucose import rate")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
-# Class: (glucose import amount)
+# Class: (D-glucose import amount)
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The amount of a glucose import.")
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "amount of glucose import")
-AnnotationAssertion(rdfs:label "glucose import amount")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The amount of a D-glucose import.")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "amount of D-glucose import")
+AnnotationAssertion(rdfs:label "D-glucose import amount")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
# Class: (heart contraction variability)
@@ -49869,11 +49875,11 @@ AnnotationAssertion(Annotation( "lipoprotein lipase activity rate")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
-# Class: (triglyceride lipase activity rate)
+# Class: (triacylglycerol lipase activity rate)
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a triglyceride lipase activity.")
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of triglyceride lipase activity")
-AnnotationAssertion(rdfs:label "triglyceride lipase activity rate")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a triacylglycerol lipase activity.")
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of triacylglycerol lipase activity")
+AnnotationAssertion(rdfs:label "triacylglycerol lipase activity rate")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
# Class: (alkaline phosphatase activity rate)
@@ -53544,12 +53550,12 @@ AnnotationAssertion(Annotation( "cholinesterase activity rate")
EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
-# Class: (L-tyrosine aminotransferase activity rate)
+# Class: (L-tyrosine-2-oxoglutarate transaminase activity rate)
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "The rate of a L-tyrosine aminotransferase activity.")
-AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute") "rate of L-tyrosine aminotransferase activity")
-AnnotationAssertion(rdfs:label "L-tyrosine aminotransferase activity rate")
-EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( )))
+AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute")