diff --git a/Tests/test_imageops.py b/Tests/test_imageops.py
index 3621aa50fbb..9f2fd5ba257 100644
--- a/Tests/test_imageops.py
+++ b/Tests/test_imageops.py
@@ -448,6 +448,15 @@ def check(orientation_im: Image.Image) -> None:
     assert 0x0112 not in transposed_im.getexif()
 
 
+def test_exif_transpose_with_xmp_tuple() -> None:
+    with Image.open("Tests/images/xmp_tags_orientation.png") as im:
+        assert im.getexif()[0x0112] == 3
+
+        im.info["xmp"] = (b"test",)
+        transposed_im = ImageOps.exif_transpose(im)
+        assert 0x0112 not in transposed_im.getexif()
+
+
 def test_exif_transpose_xml_without_xmp() -> None:
     with Image.open("Tests/images/xmp_tags_orientation.png") as im:
         assert im.getexif()[0x0112] == 3
diff --git a/src/PIL/ImageOps.py b/src/PIL/ImageOps.py
index fef1d7328c2..75dfbee22bf 100644
--- a/src/PIL/ImageOps.py
+++ b/src/PIL/ImageOps.py
@@ -729,11 +729,15 @@ def exif_transpose(image: Image.Image, *, in_place: bool = False) -> Image.Image
                         r"<tiff:Orientation>([0-9])</tiff:Orientation>",
                     ):
                         value = exif_image.info[key]
-                        exif_image.info[key] = (
-                            re.sub(pattern, "", value)
-                            if isinstance(value, str)
-                            else re.sub(pattern.encode(), b"", value)
-                        )
+                        if isinstance(value, str):
+                            value = re.sub(pattern, "", value)
+                        elif isinstance(value, tuple):
+                            value = tuple(
+                                re.sub(pattern.encode(), b"", v) for v in value
+                            )
+                        else:
+                            value = re.sub(pattern.encode(), b"", value)
+                        exif_image.info[key] = value
         if not in_place:
             return transposed_image
     elif not in_place: