diff --git a/samples/cellular/at_client/boards/nrf9280pdk_nrf9280_cpuapp.conf b/samples/cellular/at_client/boards/nrf9280pdk_nrf9280_cpuapp.conf
new file mode 100644
index 000000000000..676bb218a5c0
--- /dev/null
+++ b/samples/cellular/at_client/boards/nrf9280pdk_nrf9280_cpuapp.conf
@@ -0,0 +1,2 @@
+CONFIG_NRFS=n
+CONFIG_DCACHE=n
diff --git a/samples/cellular/at_client/boards/nrf9280pdk_nrf9280_cpuapp.overlay b/samples/cellular/at_client/boards/nrf9280pdk_nrf9280_cpuapp.overlay
new file mode 100644
index 000000000000..d2ac99aa1094
--- /dev/null
+++ b/samples/cellular/at_client/boards/nrf9280pdk_nrf9280_cpuapp.overlay
@@ -0,0 +1,23 @@
+/* Specify uart to use for at_host */
+/ {
+	chosen {
+		ncs,at-host-uart = &uart136;
+	};
+};
+
+/* Ensure access to shared memory */
+&shared_ram20_region {
+	compatible = "nordic,owned-memory";
+	perm-read;
+	perm-write;
+};
+
+&uart136_default {
+	group1 {
+		/* UARTE does not support pins 0..3. Change RTS to use P0.7.
+		 * A jumper is then required between P0.0 and P0.7 for HWFC on SW DevBrd.
+		 */
+		psels = <NRF_PSEL(UART_TX, 0, 4)>,
+			<NRF_PSEL(UART_RTS, 0, 7)>;
+	};
+};
diff --git a/samples/cellular/at_client/src/main.c b/samples/cellular/at_client/src/main.c
index f4b567e67013..b16c41aa748b 100644
--- a/samples/cellular/at_client/src/main.c
+++ b/samples/cellular/at_client/src/main.c
@@ -8,6 +8,8 @@
 #include <stdio.h>
 #include <string.h>
 #include <modem/nrf_modem_lib.h>
+
+#ifndef CONFIG_SOC_SERIES_NRF92X
 #include <zephyr/drivers/uart.h>
 #include <zephyr/drivers/clock_control.h>
 #include <zephyr/drivers/clock_control/nrf_clock_control.h>
@@ -22,6 +24,7 @@ void enable_xtal(void)
 	sys_notify_init_spinwait(&cli.notify);
 	(void)onoff_request(clk_mgr, &cli);
 }
+#endif /* CONFIG_SOC_SERIES_NRF92X */
 
 int main(void)
 {
@@ -34,7 +37,9 @@ int main(void)
 		printk("Modem library initialization failed, error: %d\n", err);
 		return 0;
 	}
+#ifndef CONFIG_SOC_SERIES_NRF92X
 	enable_xtal();
+#endif /* CONFIG_SOC_SERIES_NRF92X */
 	printk("Ready\n");
 
 	return 0;