diff --git a/samples/bluetooth/peripheral_uart/README.rst b/samples/bluetooth/peripheral_uart/README.rst
index fb7a8b28cc85..696acf936391 100644
--- a/samples/bluetooth/peripheral_uart/README.rst
+++ b/samples/bluetooth/peripheral_uart/README.rst
@@ -177,6 +177,16 @@ Building and running
 
 .. include:: /includes/nRF54H20_erase_UICR.txt
 
+Experimental nRF54H20 SoC radio core only build
+===============================================
+
+The sample can also be built in a configuration that allows it to run on the nRF54H20 SoC radio core only.
+To build the sample with this configuration, use the following command:
+
+.. code-block:: console
+
+   west build -b nrf54h20dk/nrf54h20/cpurad
+
 Experimental Bluetooth Low Energy Remote Procedure Call interface
 =================================================================
 
diff --git a/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.conf b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.conf
new file mode 100644
index 000000000000..0623953b424b
--- /dev/null
+++ b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.conf
@@ -0,0 +1,8 @@
+#
+# Copyright (c) 2024 Nordic Semiconductor
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+# Disable the unspupported UART0 driver
+CONFIG_NRFX_UARTE0=n
diff --git a/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay
new file mode 100644
index 000000000000..705300a720a8
--- /dev/null
+++ b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -0,0 +1,132 @@
+/*
+ * Copyright (c) 2024 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+ */
+
+/ {
+	chosen {
+		nordic,nus-uart = &uart135;
+		zephyr,settings_partition = &cpurad_storage_partition;
+	};
+
+	/* LEDs and buttons definitions are required for the DK Buttons and
+	 * LEDs module.
+	 */
+
+	aliases {
+		led0 = &led0;
+		led1 = &led1;
+		led2 = &led2;
+		led3 = &led3;
+
+		sw0 = &button0;
+		sw1 = &button1;
+		sw2 = &button2;
+		sw3 = &button3;
+	};
+
+	buttons {
+		compatible = "gpio-keys";
+
+		button0: button_0 {
+			gpios = <&gpio0 8 (GPIO_PULL_UP | GPIO_ACTIVE_LOW)>;
+			label = "Push button 0";
+			zephyr,code = <INPUT_KEY_0>;
+		};
+
+		button1: button_1 {
+			gpios = <&gpio0 9 (GPIO_PULL_UP | GPIO_ACTIVE_LOW)>;
+			label = "Push button 1";
+			zephyr,code = <INPUT_KEY_1>;
+		};
+
+		button2: button_2 {
+			gpios = <&gpio0 10 (GPIO_PULL_UP | GPIO_ACTIVE_LOW)>;
+			label = "Push button 2";
+			zephyr,code = <INPUT_KEY_2>;
+		};
+
+		button3: button_3 {
+			gpios = <&gpio0 11 (GPIO_PULL_UP | GPIO_ACTIVE_LOW)>;
+			label = "Push button 3";
+			zephyr,code = <INPUT_KEY_3>;
+		};
+	};
+
+	leds {
+		compatible = "gpio-leds";
+
+		led0: led_0 {
+			gpios = <&gpio9 0 GPIO_ACTIVE_HIGH>;
+			label = "Green LED 0";
+		};
+
+		led1: led_1 {
+			gpios = <&gpio9 1 GPIO_ACTIVE_HIGH>;
+			label = "Green LED 1";
+		};
+
+		led2: led_2 {
+			gpios = <&gpio9 2 GPIO_ACTIVE_HIGH>;
+			label = "Green LED 2";
+		};
+
+		led3: led_3 {
+			gpios = <&gpio9 3 GPIO_ACTIVE_HIGH>;
+			label = "Green LED 3";
+		};
+	};
+};
+
+&gpio0 {
+	status = "okay";
+};
+
+&gpio9 {
+	status = "okay";
+};
+
+&gpiote130 {
+	status = "okay";
+	owned-channels = <4 5 6 7>;
+};
+
+/* Change to memory map to make room for read write partition for settings
+ * module.
+ *
+ * @note In case of use of the settings sotrage when running firmware on the
+ *       application core, the same memory map change must be applied to the
+*        application core DTS.
+ */
+/delete-node/ &dfu_partition;
+/delete-node/ &storage_partition;
+
+&cpuapp_rw_partitions {
+	dfu_partition: partition@100000 {
+		reg = < 0x100000 DT_SIZE_K(884) >;
+	};
+
+	storage_partition: partition@1dd000 {
+		reg = < 0x1dd000 DT_SIZE_K(24) >;
+	};
+};
+
+&mram1x {
+	cpurad_rw_partitions: cpurad-rw-partitions {
+		compatible = "nordic,owned-partitions", "fixed-partitions";
+		perm-read;
+		perm-write;
+		perm-secure;
+		#address-cells = <1>;
+		#size-cells = <1>;
+
+		cpurad_storage_partition: partition@1e3000 {
+			reg = <0x1e3000 DT_SIZE_K(24)>;
+		};
+	};
+};
+
+&cpurad_rw_partitions {
+	status = "okay";
+};