diff --git a/CHANGES.md b/CHANGES.md
index 97646a9d1..1c6155313 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -2,6 +2,12 @@
 
 ## __NEXT__
 
+### Features
+
+* Constrain `bcbio-gff` to >=0.7.0 and allow `Biopython` >=1.81 again. We had to introduce the `Biopython` constraint in v21.0.1 (see [#1152][]) due to `bcbio-gff` <0.7.0 relying on the removed `Biopython` feature `UnknownSeq`. [#1178][] (@corneliusroemer)
+
+[#1152]: https://github.com/nextstrain/augur/pull/1152
+[#1178]: https://github.com/nextstrain/augur/pull/1178
 
 ## 21.1.0 (14 March 2023)
 
diff --git a/setup.py b/setup.py
index 72a6864ef..2ed0bdd1f 100644
--- a/setup.py
+++ b/setup.py
@@ -51,12 +51,8 @@
     package_data = {'augur': ['data/*']},
     python_requires = '>={}'.format('.'.join(str(n) for n in py_min_version)),
     install_requires = [
-        "bcbio-gff >=0.6.0, ==0.6.*",
-        # TODO: Remove biopython <=1.80 pin when 1.81/higher is supported by a
-        # new version of bcbio-gff¹ and that is also pinned, or when bcbio-gff
-        # is no longer a dependency.
-        # ¹ https://github.com/chapmanb/bcbb/issues/136
-        "biopython >=1.67, !=1.77, !=1.78, <=1.80",
+        "bcbio-gff >=0.7.0, ==0.7.*",
+        "biopython >=1.67, !=1.77, !=1.78",
         "cvxopt >=1.1.9, ==1.*",
         "isodate ==0.6.*",
         "jsonschema >=3.0.0, ==3.*",