Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Integrate DEGAS_contributionVar with DEGAS_contributionGene #3

Open
bschilder opened this issue Aug 23, 2021 · 0 comments
Open

Integrate DEGAS_contributionVar with DEGAS_contributionGene #3

bschilder opened this issue Aug 23, 2021 · 0 comments
Assignees
Labels
enhancement New feature or request

Comments

@bschilder
Copy link
Collaborator

bschilder commented Aug 23, 2021

If you run an integrative algorithm on these two sets of reductions, you could get some useful variant-gene relationships (both cis- and trans-).

MOFA+ seems like a good tool for this, since you're essentially learning multi-modal relationships from the same set of samples. MOFA+ also induces sparsity constraints and can even model variation due to hierarchical metadata attributes. Plus you can accelerate with GPUs!

@bschilder bschilder self-assigned this Aug 23, 2021
@bschilder bschilder added the enhancement New feature or request label Aug 23, 2021
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
enhancement New feature or request
Projects
None yet
Development

No branches or pull requests

1 participant