diff --git a/DESCRIPTION b/DESCRIPTION index 7f0590d..41c71aa 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -22,7 +22,7 @@ Authors@R: family = "Dash", role = c("ctb"), email = "hdash.work@gmail.com", - comment = c(ORCID = "0009-0005-5514-505X"))) + comment = c(ORCID = "0009-0005-5514-505X"))) Description: Multi-Scale Target Explorer (`MSTExplorer`) systematically identifies, prioritises, and visualises cell-type-specific gene therapy targets across the phenome. License: GPL-3 diff --git a/README.Rmd b/README.Rmd index 3472b25..7d43e93 100644 --- a/README.Rmd +++ b/README.Rmd @@ -17,26 +17,56 @@ owner <- strsplit(URL,"/")[[1]][4] repo <-strsplit(URL,"/")[[1]][5] ``` -## ``r pkg``: `r title` +## Introduction -### `r description` - -If you use ``r pkg``, please cite: - - -> `r utils::citation(pkg)$textVersion` +The MSTExplorer package is an extension of the +[EWCE](https://nathanskene.github.io/EWCE/articles/EWCE.html) package. It is +designed to run expression weighted celltype enrichment (EWCE) on multiple gene +lists in parallel. The results are then stored both as separate .rds files, one +for each individual EWCE analysis, as well as a in a single dataframe +containing all the results. This package is useful in cases where you have a +large number of related, but separate, gene lists. ## Installation +Within R: + ```R if(!require("remotes")) install.packages("remotes") remotes::install_github("`r paste(owner,repo,sep='/')`") library(`r pkg`) ``` + ## Documentation -### [Website](https://`r owner`.github.io/`r pkg`) -### [Get started](https://`r owner`.github.io/`r pkg`/articles/`r pkg`) +#### [Website](https://`r owner`.github.io/`r pkg`) +#### [Get started](https://`r owner`.github.io/`r pkg`/articles/`r pkg`) +#### [Docker/Singularity Container](https://`r owner`.github.io/`r pkg`/articles/docker.html) + +## Citation + +If you use ``r pkg``, please cite: + + +> `r utils::citation(pkg)$textVersion` + +## Contact + +### [Neurogenomics Lab](https://www.neurogenomics.co.uk) +UK Dementia Research Institute +Department of Brain Sciences +Faculty of Medicine +Imperial College London +[GitHub](https://github.com/neurogenomics) + +## Session Info + +
+ +```{r Session Info} +utils::sessionInfo() +``` -
+
+
diff --git a/README.md b/README.md index 0a41d15..67fe9a5 100644 --- a/README.md +++ b/README.md @@ -16,14 +16,42 @@ Authors: Brian Schilder, Robert Gordon-Smith, Nathan Skene, Hiranyamaya Dash

-README updated: Dec-16-2024 +README updated: Jan-06-2025

-## `MSTExplorer`: Multi-Scale Target Explorer +## Introduction -### Multi-Scale Target Explorer (`MSTExplorer`) systematically identifies, prioritises, and visualises cell-type-specific gene therapy targets across the phenome. +The MSTExplorer package is an extension of the +[EWCE](https://nathanskene.github.io/EWCE/articles/EWCE.html) package. +It is designed to run expression weighted celltype enrichment (EWCE) on +multiple gene lists in parallel. The results are then stored both as +separate .rds files, one for each individual EWCE analysis, as well as a +in a single dataframe containing all the results. This package is useful +in cases where you have a large number of related, but separate, gene +lists. + +## Installation + +Within R: + +``` r +if(!require("remotes")) install.packages("remotes") + +remotes::install_github("neurogenomics/MSTExplorer") +library(MSTExplorer) +``` + +## Documentation + +#### [Website](https://neurogenomics.github.io/MSTExplorer) + +#### [Get started](https://neurogenomics.github.io/MSTExplorer/articles/MSTExplorer) + +#### [Docker/Singularity Container](https://neurogenomics.github.io/MSTExplorer/articles/docker.html) + +## Citation If you use `MSTExplorer`, please cite: @@ -34,19 +62,59 @@ If you use `MSTExplorer`, please cite: > type-specific gene targets underlying thousands of rare diseases and > subtraits. medRxiv, -## Installation +## Contact -``` r -if(!require("remotes")) install.packages("remotes") +### [Neurogenomics Lab](https://www.neurogenomics.co.uk) -remotes::install_github("neurogenomics/MSTExplorer") -library(MSTExplorer) -``` +UK Dementia Research Institute +Department of Brain Sciences +Faculty of Medicine +Imperial College London +[GitHub](https://github.com/neurogenomics) -## Documentation +## Session Info -### [Website](https://neurogenomics.github.io/MSTExplorer) +
-### [Get started](https://neurogenomics.github.io/MSTExplorer/articles/MSTExplorer) +``` r +utils::sessionInfo() +``` -
+ ## R version 4.4.2 (2024-10-31) + ## Platform: aarch64-apple-darwin20 + ## Running under: macOS Sequoia 15.2 + ## + ## Matrix products: default + ## BLAS: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRblas.0.dylib + ## LAPACK: /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/lib/libRlapack.dylib; LAPACK version 3.12.0 + ## + ## locale: + ## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 + ## + ## time zone: Europe/London + ## tzcode source: internal + ## + ## attached base packages: + ## [1] stats graphics grDevices utils datasets methods base + ## + ## loaded via a namespace (and not attached): + ## [1] gtable_0.3.6 jsonlite_1.8.9 renv_1.0.11 + ## [4] dplyr_1.1.4 compiler_4.4.2 BiocManager_1.30.25 + ## [7] tidyselect_1.2.1 rvcheck_0.2.1 scales_1.3.0 + ## [10] yaml_2.3.10 fastmap_1.2.0 here_1.0.1 + ## [13] ggplot2_3.5.1 R6_2.5.1 generics_0.1.3 + ## [16] knitr_1.49 yulab.utils_0.1.8 tibble_3.2.1 + ## [19] desc_1.4.3 dlstats_0.1.7 rprojroot_2.0.4 + ## [22] munsell_0.5.1 pillar_1.9.0 RColorBrewer_1.1-3 + ## [25] rlang_1.1.4 utf8_1.2.4 badger_0.2.4 + ## [28] xfun_0.49 fs_1.6.5 cli_3.6.3 + ## [31] magrittr_2.0.3 rworkflows_1.0.3 digest_0.6.37 + ## [34] grid_4.4.2 rstudioapi_0.17.1 lifecycle_1.0.4 + ## [37] vctrs_0.6.5 evaluate_1.0.1 glue_1.8.0 + ## [40] data.table_1.16.2 fansi_1.0.6 colorspace_2.1-1 + ## [43] rmarkdown_2.29 tools_4.4.2 pkgconfig_2.0.3 + ## [46] htmltools_0.5.8.1 + +
+ +