diff --git a/src/build-system/cmake/CMake.NCBIComponentsXCODE.cmake b/src/build-system/cmake/CMake.NCBIComponentsXCODE.cmake
index d183b632ce..bfd0c557fc 100644
--- a/src/build-system/cmake/CMake.NCBIComponentsXCODE.cmake
+++ b/src/build-system/cmake/CMake.NCBIComponentsXCODE.cmake
@@ -50,6 +50,7 @@ set(NCBI_ThirdParty_VDB_ARCH x86_64)
 set(NCBI_ThirdParty_FTGL      ${NCBI_TOOLS_ROOT}/ftgl-2.1.3-rc5 CACHE PATH "FTGL root")
 set(NCBI_ThirdParty_GLEW      ${NCBI_TOOLS_ROOT}/glew-1.5.8 CACHE PATH "GLEW root")
 set(NCBI_ThirdParty_GRPC      ${NCBI_TOOLS_ROOT}/grpc-1.36.4-ncbi1 CACHE PATH "GRPC root")
+set(NCBI_ThirdParty_Boring    ${NCBI_ThirdParty_GRPC})
 set(NCBI_ThirdParty_PROTOBUF  ${NCBI_TOOLS_ROOT}/grpc-1.36.4-ncbi1 CACHE PATH "PROTOBUF root")
 set(NCBI_ThirdParty_wxWidgets ${NCBI_TOOLS_ROOT}/wxWidgets-3.1.4-ncbi2 CACHE PATH "wxWidgets root")
 set(NCBI_ThirdParty_UV        ${NCBI_TOOLS_ROOT}/libuv-1.35.0 CACHE PATH "UV root")
@@ -451,11 +452,23 @@ endif()
 
 if ("${CMAKE_BUILD_TYPE}" STREQUAL "Debug")
     NCBI_define_Xcomponent(NAME PROTOBUF LIB protobufd)
-else()
+endif()
+if(NOT NCBI_COMPONENT_PROTOBUF_FOUND)
     NCBI_define_Xcomponent(NAME PROTOBUF MODULE protobuf PACKAGE Protobuf LIB protobuf)
 endif()
-NCBI_define_Xcomponent(NAME GRPC MODULE grpc++)
+NCBI_define_Xcomponent(NAME Boring LIB boringssl boringcrypto)
+NCBI_define_Xcomponent(NAME GRPC MODULE grpc++ LIB
+    grpc++ grpc address_sorting upb cares gpr re2
+    absl_raw_hash_set absl_hashtablez_sampler absl_exponential_biased absl_hash 
+    absl_city absl_statusor absl_bad_variant_access absl_status absl_cord 
+    absl_str_format_internal absl_synchronization absl_graphcycles_internal 
+    absl_symbolize absl_demangle_internal absl_stacktrace absl_debugging_internal 
+    absl_malloc_internal absl_time absl_time_zone absl_civil_time absl_strings 
+    absl_strings_internal absl_throw_delegate absl_int128 absl_base absl_spinlock_wait 
+    absl_bad_optional_access absl_raw_logging_internal absl_log_severity
+    )
 if(NCBI_COMPONENT_GRPC_FOUND)
+    set(NCBI_COMPONENT_GRPC_LIBS ${NCBI_COMPONENT_GRPC_LIBS} ${NCBI_COMPONENT_Boring_LIBS})
     set(NCBI_COMPONENT_GRPC_LIBS ${NCBI_COMPONENT_GRPC_LIBS} ${COREFOUNDATION_LIBS})
 endif()
 
diff --git a/src/build-system/cmake/CMake.NCBIptb.cmake b/src/build-system/cmake/CMake.NCBIptb.cmake
index c7a1f72f4e..98e6157a64 100644
--- a/src/build-system/cmake/CMake.NCBIptb.cmake
+++ b/src/build-system/cmake/CMake.NCBIptb.cmake
@@ -1,5 +1,5 @@
 #############################################################################
-# $Id$
+# $Id: CMake.NCBIptb.cmake 643192 2022-01-06 13:49:42Z gouriano $
 #############################################################################
 #############################################################################
 ##
@@ -241,16 +241,31 @@ function(NCBI_add_target)
 endfunction()
 
 #############################################################################
-macro(NCBI_begin_lib _name)
+macro(NCBI_begin_lib _aname)
     if( NOT NCBI_PTBMODE_PARTS AND NOT "${NCBI_PROJECT_expected}" STREQUAL "" AND NOT "${NCBI_PROJECT_expected}" STREQUAL "library")
         message(SEND_ERROR "${NCBI_CURRENT_SOURCE_DIR}/${NCBI_PROJECT}: Unexpected NCBI_begin_lib call")
     endif()
+    set(_name ${_aname})
+    set(_general_target NO)
+    if(NCBI_PTBCFG_PACKAGING OR NCBI_PTBCFG_PACKAGED)
+        if(${_name} STREQUAL "general" OR ${_name} STREQUAL "generalasn")
+            set(_name "generalasn")
+            if (DEFINED NCBI_EXTERNAL_TREE_ROOT)
+                if(TARGET general)
+                    set(_name "general")
+                    set(_general_target YES)
+                elseif(TARGET generalasn)
+                    set(_general_target YES)
+                endif()
+            endif()
+        endif()
+    endif()
     if(NCBI_PTBMODE_PARTS)
         set(_libname ${_name}.part)
     else()
         set(_libname ${_name})
     endif()
-    if (DEFINED NCBI_EXTERNAL_TREE_ROOT AND TARGET ${_name})
+    if (DEFINED NCBI_EXTERNAL_TREE_ROOT AND (TARGET ${_name} OR _general_target))
         set(_libname ${_libname}.local)
         if (NCBI_PTBMODE_COLLECT_DEPS)
             set_property(GLOBAL PROPERTY NCBI_PTBPROP_LOCAL_${_name} "${_libname}")
@@ -778,7 +793,7 @@ macro(NCBI_internal_analyze_tree)
             NCBI_internal_collect_dependencies(${_prj})
             get_property(_prjdeps GLOBAL PROPERTY NCBI_PTBPROP_DEPS_${_prj})
             get_property(_host GLOBAL PROPERTY NCBI_PTBPROP_HOST_${_prj})
-            set(NCBI_PTB_ALLOWED_PROJECTS ${NCBI_PTB_ALLOWED_PROJECTS} ${_host} ${_prj} ${_prjdeps})
+            list(APPEND NCBI_PTB_ALLOWED_PROJECTS ${_host} ${_prj} ${_prjdeps})
         endforeach()
         list(SORT NCBI_PTB_ALLOWED_PROJECTS)
         list(REMOVE_DUPLICATES NCBI_PTB_ALLOWED_PROJECTS)
@@ -789,7 +804,7 @@ macro(NCBI_internal_analyze_tree)
                 NCBI_internal_collect_dependencies(${_prj})
                 get_property(_prjdeps GLOBAL PROPERTY NCBI_PTBPROP_DEPS_${_prj})
                 get_property(_host GLOBAL PROPERTY NCBI_PTBPROP_HOST_${_prj})
-                set(NCBI_PTB_ALLOWED_PROJECTS ${NCBI_PTB_ALLOWED_PROJECTS} ${_host} ${_prj} ${_prjdeps})
+                list(APPEND NCBI_PTB_ALLOWED_PROJECTS ${_host} ${_prj} ${_prjdeps})
             endforeach()
             list(SORT NCBI_PTB_ALLOWED_PROJECTS)
             list(REMOVE_DUPLICATES NCBI_PTB_ALLOWED_PROJECTS)
@@ -936,7 +951,7 @@ function(NCBI_internal_recur_collect_dependencies _project _dep)
     foreach( _value IN LISTS _dep _depdeps)
         NCBI_internal_collect_dependencies(${_value}) 
         get_property(_valuedeps GLOBAL PROPERTY NCBI_PTBPROP_DEPS_${_value})
-        set(_prjdeps ${_prjdeps} ${_value} ${_valuedeps})
+        list(APPEND _prjdeps ${_value} ${_valuedeps})
     endforeach()
     if (NOT "${_prjdeps}" STREQUAL "")
         list(SORT _prjdeps)
@@ -1118,14 +1133,14 @@ function(NCBI_internal_collect_headers)
         if ( NOT "${_headers}" STREQUAL "")
             foreach(_mask IN LISTS _headers)
                 file(GLOB _files LIST_DIRECTORIES false "${NCBI_CURRENT_SOURCE_DIR}/${_mask}")
-                set(_priv ${_priv} ${_files})
+                list(APPEND _priv ${_files})
                 if (NOT "${_inc_dir}" STREQUAL "")
                     if (${_mask} MATCHES "[.]inl$")
                         file(GLOB _files LIST_DIRECTORIES false "${_inc_dir}/${_mask}")
-                        set(_inl ${_inl} ${_files})
+                        list(APPEND _inl ${_files})
                     else()
                         file(GLOB _files LIST_DIRECTORIES false "${_inc_dir}/${_mask}")
-                        set(_pub ${_pub} ${_files})
+                        list(APPEND _pub ${_files})
                     endif()
                 endif()
             endforeach()
@@ -1192,9 +1207,9 @@ function(NCBI_internal_collect_dataspec)
             string(TOLOWER ${_ext} _ext)
             set( NCBI_PTB_CALLBACK_DATASPEC${_ext} ${_input})
             cmake_parse_arguments(DT "" "DATASPEC" "SOURCES;HEADERS;INCLUDE" ${_output})
-            set(_specfiles ${_specfiles} ${DT_DATASPEC})
-            set(_srcfiles ${_srcfiles} ${DT_SOURCES})
-            set(_incfiles ${_incfiles} ${DT_HEADERS})
+            list(APPEND _specfiles ${DT_DATASPEC})
+            list(APPEND _srcfiles ${DT_SOURCES})
+            list(APPEND _incfiles ${DT_HEADERS})
         else()
             message(SEND_ERROR "file not found: ${NCBI_CURRENT_SOURCE_DIR}/${_dataspec}")
         endif()
@@ -1358,13 +1373,12 @@ macro(NCBI_internal_process_project_requires)
             if (_negate)
                 set(NCBITMP_REQUIRE_NOTFOUND ${NCBITMP_REQUIRE_NOTFOUND} ${_req})
             else()
-#                set(NCBITMP_INCLUDES ${NCBITMP_INCLUDES} ${NCBI_COMPONENT_${_value}_INCLUDE})
-                set(NCBITMP_INCLUDES_SYSTEM ${NCBITMP_INCLUDES_SYSTEM} ${NCBI_COMPONENT_${_value}_INCLUDE})
-                set(NCBITMP_DEFINES  ${NCBITMP_DEFINES}  ${NCBI_COMPONENT_${_value}_DEFINES})
-                set(NCBITMP_EXTLIB   ${NCBITMP_EXTLIB}   ${NCBI_COMPONENT_${_value}_LIBS})
+                list(APPEND NCBITMP_INCLUDES_SYSTEM ${NCBI_COMPONENT_${_value}_INCLUDE})
+                list(APPEND NCBITMP_DEFINES  ${NCBI_COMPONENT_${_value}_DEFINES})
+                list(APPEND NCBITMP_EXTLIB   ${NCBI_COMPONENT_${_value}_LIBS})
                 foreach(_lib IN LISTS NCBI_COMPONENT_${_value}_NCBILIB)
                     if(NOT ${_lib} STREQUAL ${NCBI_${NCBI_PROJECT}_OUTPUT})
-                        set(NCBITMP_NCBILIB  ${NCBITMP_NCBILIB}  ${_lib})
+                        list(APPEND NCBITMP_NCBILIB  ${_lib})
                     endif()
                 endforeach()
                 if (NOT NCBI_PTBMODE_COLLECT_DEPS)
@@ -1378,7 +1392,7 @@ macro(NCBI_internal_process_project_requires)
 #        set(NCBITMP_DEFINES  ${NCBITMP_DEFINES}  ${NCBI_COMPONENT_${_value}_DEFINES})
 #        set(NCBITMP_EXTLIB     ${NCBITMP_EXTLIB}     ${NCBI_COMPONENT_${_value}_LIBS})
             else()
-                set(NCBITMP_REQUIRE_NOTFOUND ${NCBITMP_REQUIRE_NOTFOUND} ${_req})
+                list(APPEND NCBITMP_REQUIRE_NOTFOUND ${_req})
             endif()
         endif()     
     endforeach()
@@ -1390,11 +1404,11 @@ macro(NCBI_internal_process_project_requires)
             NCBI_util_parse_sign(${_req} _value _negate)
             if (${_value} OR NCBI_REQUIRE_${_value}_FOUND OR NCBI_COMPONENT_${_value}_FOUND)
                 if (_negate)
-                    set(NCBITMP_REQUIRE_NOTFOUND ${NCBITMP_REQUIRE_NOTFOUND} ${_req})
+                    list(APPEND NCBITMP_REQUIRE_NOTFOUND ${_req})
                 endif()
             else()
                 if (NOT _negate)
-                    set(NCBITMP_REQUIRE_NOTFOUND ${NCBITMP_REQUIRE_NOTFOUND} ${_req})
+                    list(APPEND NCBITMP_REQUIRE_NOTFOUND ${_req})
                 endif()
             endif()     
         endforeach()
@@ -1430,20 +1444,19 @@ macro(NCBI_internal_process_project_components)
             set(_value ${NCBI_COMPONENT_${_value}_FOUND})
         endif()
         if (${_value} OR NCBI_REQUIRE_${_value}_FOUND OR NCBI_COMPONENT_${_value}_FOUND)
-#            set(NCBITMP_INCLUDES ${NCBITMP_INCLUDES} ${NCBI_COMPONENT_${_value}_INCLUDE})
-            set(NCBITMP_INCLUDES_SYSTEM ${NCBITMP_INCLUDES_SYSTEM} ${NCBI_COMPONENT_${_value}_INCLUDE})
-            set(NCBITMP_DEFINES  ${NCBITMP_DEFINES}  ${NCBI_COMPONENT_${_value}_DEFINES})
-            set(NCBITMP_EXTLIB   ${NCBITMP_EXTLIB}   ${NCBI_COMPONENT_${_value}_LIBS})
+            list(APPEND NCBITMP_INCLUDES_SYSTEM ${NCBI_COMPONENT_${_value}_INCLUDE})
+            list(APPEND NCBITMP_DEFINES  ${NCBI_COMPONENT_${_value}_DEFINES})
+            list(APPEND NCBITMP_EXTLIB   ${NCBI_COMPONENT_${_value}_LIBS})
             foreach(_lib IN LISTS NCBI_COMPONENT_${_value}_NCBILIB)
                 if(NOT ${_lib} STREQUAL ${NCBI_${NCBI_PROJECT}_OUTPUT})
-                    set(NCBITMP_NCBILIB  ${NCBITMP_NCBILIB}  ${_lib})
+                    list(APPEND NCBITMP_NCBILIB  ${_lib})
                 endif()
             endforeach()
             if (NOT NCBI_PTBMODE_COLLECT_DEPS)
                 NCBI_internal_install_component_files(${_value})
             endif()
         else()
-            set(NCBITMP_COMPONENT_NOTFOUND ${NCBITMP_COMPONENT_NOTFOUND} ${_value})
+            list(APPEND NCBITMP_COMPONENT_NOTFOUND ${_value})
         endif()
     endforeach()
 endmacro()
@@ -1466,6 +1479,9 @@ function(NCBI_internal_collect_parts _result)
     endforeach()
 
     set(NCBI_PTBMODE_PARTS ON)
+    if(NCBI_VERBOSE_ALLPROJECTS OR NCBI_VERBOSE_PROJECT_${NCBI_PROJECT})
+        message("${NCBI_PROJECT} parts: ${NCBI_${_hostproject}_PARTS}")
+    endif()
     foreach(_part IN LISTS NCBI_${_hostproject}_PARTS)
         set(_filepath ${NCBI_SRC_ROOT}/${_part})
         get_filename_component(_path ${_filepath} DIRECTORY)
@@ -1526,9 +1542,9 @@ macro(NCBI_internal_process_parts _result)
 
     set(NCBITMP_PROJECT_PART_IDS "")
     set(NCBITMP_PROJECT_PARTS "")
-    NCBI_internal_collect_parts(_result)
+    NCBI_internal_collect_parts(${_result})
 
-    if(_result)
+    if(${_result})
         if (NCBI_PTBMODE_COLLECT_DEPS OR NOT NCBI_PTBCFG_ENABLE_COLLECTOR)
 #set_property(GLOBAL PROPERTY NCBI_PTBPROP_PARTS_${NCBI_PROJECT_ID} ${NCBITMP_PROJECT_PART_IDS})
             foreach(_part IN LISTS NCBITMP_PROJECT_PART_IDS)
@@ -1539,6 +1555,13 @@ macro(NCBI_internal_process_parts _result)
                     set_property(GLOBAL PROPERTY NCBI_PTBPROP_HOST_${_part} ${NCBI_PROJECT})
                 endif()
             endforeach()
+            if(NCBI_PTBCFG_PACKAGING OR NCBI_PTBCFG_PACKAGED)
+                if("general" IN_LIST NCBITMP_PROJECT_PARTS)
+                    set_property(GLOBAL PROPERTY NCBI_PTBPROP_HOST_generalasn ${NCBI_PROJECT})
+                elseif("generalasn" IN_LIST NCBITMP_PROJECT_PARTS)
+                    set_property(GLOBAL PROPERTY NCBI_PTBPROP_HOST_general ${NCBI_PROJECT})
+                endif()
+            endif()
         endif()
     endif()
 endmacro()
@@ -1554,10 +1577,10 @@ function(NCBI_internal_process_interface_libraries _lib)
         foreach(_prj IN LISTS _deps)
             get_property(_local GLOBAL PROPERTY NCBI_PTBPROP_LOCAL_${_prj})
             if ("${_local}" STREQUAL "" OR NOT ${_local} IN_LIST NCBI_PTB_ALLOWED_PROJECTS)
-                set(_value ${_value} ${_prj})
+                list(APPEND _value ${_prj})
                 NCBI_internal_process_interface_libraries("${_prj}")
             else()
-                set(_value ${_value} ${_local})
+                list(APPEND _value ${_local})
             endif()
         endforeach()
         set_target_properties(${_lib} PROPERTIES INTERFACE_LINK_LIBRARIES "${_value}")
@@ -1570,6 +1593,16 @@ function(NCBI_internal_verify_ncbilibs)
     set(_exclude "")
     foreach(_prj IN LISTS NCBITMP_NCBILIB)
         NCBI_util_parse_sign(${_prj} _value _negate)
+        if(NCBI_PTBCFG_PACKAGING OR NCBI_PTBCFG_PACKAGED)
+                if(${_value} STREQUAL "general" OR ${_value} STREQUAL "generalasn")
+                    set(_value "generalasn")
+                    if (DEFINED NCBI_EXTERNAL_TREE_ROOT)
+                        if(TARGET general)
+                            set(_value "general")
+                        endif()
+                    endif()
+                endif()
+        endif()
         list(APPEND _res ${_value})
         if (_negate)
             list(APPEND _exclude ${_value})
@@ -1613,13 +1646,13 @@ function(NCBI_internal_verify_libs)
                 if (_optimize)
                     get_property(_hasspec GLOBAL PROPERTY NCBI_PTBPROP_DATASPEC_${_prj})
                     if (_hasspec)
-                        set(_value ${_value} ${_prj})
+                        list(APPEND _value ${_prj})
                     endif()
                 else()
-                    set(_value ${_value} ${_prj})
+                    list(APPEND _value ${_prj})
                 endif()
             else()
-                set(_value ${_value} ${_host})
+                list(APPEND _value ${_host})
             endif()
         endforeach()
     endif()
@@ -1634,10 +1667,10 @@ function(NCBI_internal_verify_libs)
         foreach(_prj IN LISTS _ncbilib)
             get_property(_local GLOBAL PROPERTY NCBI_PTBPROP_LOCAL_${_prj})
             if ("${_local}" STREQUAL "" OR NOT ${_local} IN_LIST NCBI_PTB_ALLOWED_PROJECTS)
-                set(_value ${_value} ${_prj})
+                list(APPEND _value ${_prj})
                 NCBI_internal_process_interface_libraries("${_prj}")
             else()
-                set(_value ${_value} ${_local})
+                list(APPEND _value ${_local})
             endif()
         endforeach()
     endif()
@@ -1647,9 +1680,9 @@ function(NCBI_internal_verify_libs)
         set(_value "")
         foreach(_tk_lib IN LISTS _tk_libs)
             if(${_tk_lib} STREQUAL "general")
-                set(_value ${_value} \$<1:general>)
+                list(APPEND _value \$<1:general>)
             else()
-                set(_value ${_value} ${_tk_lib})
+                list(APPEND _value ${_tk_lib})
             endif()
         endforeach()
 
@@ -2150,18 +2183,11 @@ endif()
         endif()
 
         if(NOT NCBI_PTBMODE_PARTS)
-            get_property(_allprojects GLOBAL PROPERTY NCBI_PTBPROP_ALL_PROJECTS)
-            set(_allprojects ${_allprojects} ${NCBI_PROJECT})
-            set_property(GLOBAL PROPERTY NCBI_PTBPROP_ALL_PROJECTS ${_allprojects})
+            set_property(GLOBAL APPEND PROPERTY NCBI_PTBPROP_ALL_PROJECTS ${NCBI_PROJECT})
 
             NCBI_internal_process_project_filters(_allowed)
             if (_allowed)
-                get_property(_allowedprojects GLOBAL PROPERTY NCBI_PTBPROP_ALLOWED_PROJECTS)
-                set(_allowedprojects ${_allowedprojects} ${NCBI_PROJECT})
-                set_property(GLOBAL PROPERTY NCBI_PTBPROP_ALLOWED_PROJECTS ${_allowedprojects})
-#                if(NCBI_VERBOSE_ALLPROJECTS OR NCBI_VERBOSE_PROJECT_${NCBI_PROJECT})
-#                    message("${NCBI_PROJECT} (${NCBI_CURRENT_SOURCE_DIR}): allowed: ${_allowedprojects}")
-#                endif()
+                set_property(GLOBAL APPEND PROPERTY NCBI_PTBPROP_ALLOWED_PROJECTS ${NCBI_PROJECT})
             else()
                 if(NCBI_VERBOSE_ALLPROJECTS OR NCBI_VERBOSE_PROJECT_${NCBI_PROJECT})
                     message("${NCBI_PROJECT} (${NCBI_CURRENT_SOURCE_DIR}): is excluded by project filters")