diff --git a/Makefile b/Makefile
index ae3314e..1f5bdf0 100644
--- a/Makefile
+++ b/Makefile
@@ -65,7 +65,7 @@ PYTHON_PACKAGE_INSTALLER?=uv
 # Flag whether to use a global installed 'uv' or install
 # it in the virtual environment.
 # Default: false
-PYTHON_UV_GLOBAL?=true
+PYTHON_UV_GLOBAL?=false
 
 # Flag whether to use virtual environment. If `false`, the
 # interpreter according to `PRIMARY_PYTHON` found in `PATH` is used.
diff --git a/src/mxmake/tests/test_parser.py b/src/mxmake/tests/test_parser.py
index a7a511b..eafcc24 100644
--- a/src/mxmake/tests/test_parser.py
+++ b/src/mxmake/tests/test_parser.py
@@ -21,6 +21,8 @@ def test_MakefileParser(self, tempdir):
             "core.base.EXTRA_PATH": "",
             "core.mxenv.PRIMARY_PYTHON": "python3",
             "core.mxenv.PYTHON_MIN_VERSION": "3.7",
+            "core.mxenv.PYTHON_PACKAGE_INSTALLER": "pip",
+            "core.mxenv.PYTHON_UV_GLOBAL": "false",
             "core.mxenv.VENV_ENABLED": "true",
             "core.mxenv.VENV_CREATE": "true",
             "core.mxenv.VENV_FOLDER": "venv",
@@ -65,6 +67,8 @@ def test_MakefileParser(self, tempdir):
                 "core.base.EXTRA_PATH": "",
                 "core.mxenv.PRIMARY_PYTHON": "python3",
                 "core.mxenv.PYTHON_MIN_VERSION": "3.7",
+                "core.mxenv.PYTHON_PACKAGE_INSTALLER": "pip",
+                "core.mxenv.PYTHON_UV_GLOBAL": "false",
                 "core.mxenv.VENV_ENABLED": "true",
                 "core.mxenv.VENV_CREATE": "true",
                 "core.mxenv.VENV_FOLDER": "venv",
diff --git a/src/mxmake/tests/test_templates.py b/src/mxmake/tests/test_templates.py
index 78a2b0c..7984627 100644
--- a/src/mxmake/tests/test_templates.py
+++ b/src/mxmake/tests/test_templates.py
@@ -526,6 +526,8 @@ def test_Makefile(self, tempdir):
             "core.base.EXTRA_PATH": "",
             "core.mxenv.PRIMARY_PYTHON": "python3",
             "core.mxenv.PYTHON_MIN_VERSION": "3.7",
+            "core.mxenv.PYTHON_PACKAGE_INSTALLER": "pip",
+            "core.mxenv.PYTHON_UV_GLOBAL": "false",
             "core.mxenv.VENV_ENABLED": "true",
             "core.mxenv.VENV_CREATE": "true",
             "core.mxenv.VENV_FOLDER": "venv",
@@ -596,6 +598,11 @@ def test_Makefile(self, tempdir):
                 # Default: pip
                 PYTHON_PACKAGE_INSTALLER?=pip
 
+                # Flag whether to use a global installed 'uv' or install
+                # it in the virtual environment.
+                # Default: false
+                PYTHON_UV_GLOBAL?=false
+
                 # Flag whether to use virtual environment. If `false`, the
                 # interpreter according to `PRIMARY_PYTHON` found in `PATH` is used.
                 # Default: true
@@ -683,20 +690,44 @@ def test_Makefile(self, tempdir):
                 MXENV_PYTHON=$(PRIMARY_PYTHON)
                 endif
 
+                # determine the package installer
+                ifeq ("$(PYTHON_PACKAGE_INSTALLER)","uv")
+                # use uv
+                PYTHON_PACKAGE_COMMAND=uv pip
+                else
+                # use/default to pip
+                PYTHON_PACKAGE_COMMAND=$(MXENV_PYTHON) -m pip
+                endif # /PYTHON_PACKAGE_INSTALLER
+
                 MXENV_TARGET:=$(SENTINEL_FOLDER)/mxenv.sentinel
                 $(MXENV_TARGET): $(SENTINEL)
                 ifeq ("$(VENV_ENABLED)", "true")
+                # Use a venv
                 ifeq ("$(VENV_CREATE)", "true")
-                	@echo "Setup Python Virtual Environment under '$(VENV_FOLDER)'"
-                	@$(PRIMARY_PYTHON) -m venv $(VENV_FOLDER)
-                endif
-                endif
-                	@$(MXENV_PYTHON) -m ensurepip -U
-                	@$(PYTHON_PACKAGE_COMMAND) install -U pip setuptools wheel
-                	@$(PYTHON_PACKAGE_COMMAND) install -U $(MXDEV)
-                	@$(PYTHON_PACKAGE_COMMAND) install -U $(MXMAKE)
-                	@touch $(MXENV_TARGET)
-
+                # Create a venv
+                ifeq ("$(PYTHON_PACKAGE_INSTALLER)$(PYTHON_UV_GLOBAL)", "uvtrue")
+                # create venv with global uv
+                    @echo "Setup Python Virtual Environment using package 'uv' at '$(VENV_FOLDER)'"
+                    @uv venv -p $(PRIMARY_PYTHON) --seed $(VENV_FOLDER)
+                else
+                    @echo "Setup Python Virtual Environment using module 'venv' at '$(VENV_FOLDER)'"
+                    @$(MXENV_PYTHON) -m venv $(VENV_FOLDER)
+                    @$(MXENV_PYTHON) -m ensurepip -U
+                endif # /PYTHON_PACKAGE_INSTALLER uv and PYTHON_UV_GLOBAL
+
+                ifeq ("$(PYTHON_PACKAGE_INSTALLER)$(PYTHON_UV_GLOBAL)", "uvfalse")
+                    @echo "Install uv"
+                    @$(MXENV_PYTHON) -m pip install uv
+                endif # /PYTHON_PACKAGE_INSTALLER uv and not PYTHON_UV_GLOBAL
+                    # always update pip, setuptools and wheel
+                    @$(PYTHON_PACKAGE_COMMAND) install -U pip setuptools wheel
+                endif # /VENV_CREATE
+                else
+                    @echo "Using system Python interpreter"
+                endif # /VENV_ENABLED
+                    @echo "Install/Update MXStack Python packages"
+                    @$(PYTHON_PACKAGE_COMMAND) install -U $(MXDEV) $(MXMAKE)
+                    @touch $(MXENV_TARGET)
                 .PHONY: mxenv
                 mxenv: $(MXENV_TARGET)