diff --git a/doc/news/DM-46883.perf.rst b/doc/news/DM-46883.perf.rst
new file mode 100644
index 000000000..b3b8a5735
--- /dev/null
+++ b/doc/news/DM-46883.perf.rst
@@ -0,0 +1 @@
+Add dofs vector option for `apply_dof.py` script.
\ No newline at end of file
diff --git a/python/lsst/ts/standardscripts/maintel/apply_dof.py b/python/lsst/ts/standardscripts/maintel/apply_dof.py
index 37e5ec9f8..de5e48a68 100644
--- a/python/lsst/ts/standardscripts/maintel/apply_dof.py
+++ b/python/lsst/ts/standardscripts/maintel/apply_dof.py
@@ -79,6 +79,17 @@ def get_schema(cls) -> typing.Dict[str, typing.Any]:
             description: Configuration for ApplyDOF Script.
             type: object
             properties:
+              dofs:
+                type: array
+                description: >-
+                  Defines a 50-dimensional vector for all DOFs, combining M2,
+                  Camera, M1M3, and M2 bending modes. This overrides individual DOF inputs.
+                  First 5 elements for M2, next 5 for Camera, next 20 for M1M3 bending modes,
+                  last 20 for M2 bending modes. Units: microns or arcsec.
+                items:
+                  type: number
+                minItems: 50
+                maxItems: 50
               M2_dz:
                   type: number
                   description: >-
@@ -395,9 +406,12 @@ async def configure(self, config) -> None:
         # Configure tcs and camera
         await self.configure_tcs()
 
-        # Loop through properties and assign their values to the vector
-        for key, value in vars(config).items():
-            self.dofs[getattr(DOFName, key)] = value
+        if hasattr(config, "dofs"):
+            self.dofs = config.dofs
+        else:
+            # Loop through properties and assign their values to the vector
+            for key, value in vars(config).items():
+                self.dofs[getattr(DOFName, key)] = value
 
     def set_metadata(self, metadata) -> None:
         """Set script metadata.
diff --git a/tests/test_maintel_apply_dof.py b/tests/test_maintel_apply_dof.py
index ad4084292..58386878e 100644
--- a/tests/test_maintel_apply_dof.py
+++ b/tests/test_maintel_apply_dof.py
@@ -69,6 +69,21 @@ async def test_configure(self) -> None:
 
             assert all(self.script.dofs == dofs)
 
+    async def test_configure_with_dofs_vector(self) -> None:
+        async with self.make_script():
+            dofs = np.zeros(len(DOFName))
+            config_dofs = {
+                "M2_dz": 0.2,
+                "Cam_dy": 0.3,
+                "M1M3_B1": 0.5,
+                "M2_B14": 0.7,
+                "dofs": dofs,
+            }
+
+            await self.configure_script(**config_dofs)
+
+            assert all(self.script.dofs == dofs)
+
     async def test_run(self) -> None:
         # Start the test itself
         async with self.make_script():