This is the example meow-setup function for Dvorak Simplified layout.
Add it to your configuration and call it before (meow-global-mode 1).
(defun meow-setup ()
(setq meow-cheatsheet-layout meow-cheatsheet-layout-dvorak)
(meow-leader-define-key
'("1" . meow-digit-argument)
'("2" . meow-digit-argument)
'("3" . meow-digit-argument)
'("4" . meow-digit-argument)
'("5" . meow-digit-argument)
'("6" . meow-digit-argument)
'("7" . meow-digit-argument)
'("8" . meow-digit-argument)
'("9" . meow-digit-argument)
'("0" . meow-digit-argument)
'("/" . meow-keypad-describe-key)
'("?" . meow-cheatsheet))
(meow-motion-overwrite-define-key
;; custom keybinding for motion state
'("<escape>" . ignore))
(meow-normal-define-key
'("0" . meow-expand-0)
'("9" . meow-expand-9)
'("8" . meow-expand-8)
'("7" . meow-expand-7)
'("6" . meow-expand-6)
'("5" . meow-expand-5)
'("4" . meow-expand-4)
'("3" . meow-expand-3)
'("2" . meow-expand-2)
'("1" . meow-expand-1)
'("-" . negative-argument)
'(";" . meow-reverse)
'("," . meow-inner-of-thing)
'("." . meow-bounds-of-thing)
'("<" . meow-beginning-of-thing)
'(">" . meow-end-of-thing)
'("a" . meow-append)
'("A" . meow-open-below)
'("b" . meow-back-word)
'("B" . meow-back-symbol)
'("c" . meow-change)
'("d" . meow-delete)
'("D" . meow-backward-delete)
'("e" . meow-line)
'("E" . meow-goto-line)
'("f" . meow-find)
'("g" . meow-cancel-selection)
'("G" . meow-grab)
'("h" . meow-left)
'("H" . meow-left-expand)
'("i" . meow-insert)
'("I" . meow-open-above)
'("j" . meow-join)
'("k" . meow-kill)
'("l" . meow-till)
'("m" . meow-mark-word)
'("M" . meow-mark-symbol)
'("n" . meow-next)
'("N" . meow-next-expand)
'("o" . meow-block)
'("O" . meow-to-block)
'("p" . meow-prev)
'("P" . meow-prev-expand)
'("q" . meow-quit)
'("Q" . meow-goto-line)
'("r" . meow-replace)
'("R" . meow-swap-grab)
'("s" . meow-search)
'("t" . meow-right)
'("T" . meow-right-expand)
'("u" . meow-undo)
'("U" . meow-undo-in-selection)
'("v" . meow-visit)
'("w" . meow-next-word)
'("W" . meow-next-symbol)
'("x" . meow-save)
'("X" . meow-sync-grab)
'("y" . meow-yank)
'("z" . meow-pop-selection)
'("'" . repeat)
'("<escape>" . ignore)))