pathgo.obo

format-version: 1.2
data-version: pathgo/releases/2021-03-22/pathgo.owl
remark: Pathogenesis gene ontology
remark: This material is licensed to the public under CC BY-NC 4.0.  The U.S. Government has “Unlimited Rights” as granted and defined under FAR 52.227-14.
remark: ©2020 The Johns Hopkins University Applied Physics Laboratory LLC (JHU/APL).  All Rights Reserved.\n\nThis material may be only be used, modified, or reproduced by or for the U.S. Government pursuant to the license rights granted under the clauses at DFARS 252.227-7013/7014 or FAR 52.227-14. For any other permission, please contact the Office of Technology Transfer at JHU/APL.\n\nNO WARRANTY, NO LIABILITY. THIS MATERIAL IS PROVIDED “AS IS.” JHU/APL MAKES NO REPRESENTATION OR WARRANTY WITH RESPECT TO THE PERFORMANCE OF THE MATERIALS, INCLUDING THEIR SAFETY, EFFECTIVENESS, OR COMMERCIAL VIABILITY, AND DISCLAIMS ALL WARRANTIES IN THE MATERIAL, WHETHER EXPRESS OR IMPLIED, INCLUDING (BUT NOT LIMITED TO) ANY AND ALL IMPLIED WARRANTIES OF PERFORMANCE, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, AND NON-INFRINGEMENT OF INTELLECTUAL PROPERTY OR OTHER THIRD PARTY RIGHTS. ANY USER OF THE MATERIAL ASSUMES THE ENTIRE RISK AND LIABILITY FOR USING THE MATERIAL. IN NO EVENT SHALL JHU/APL BE LIABLE TO ANY USER OF THE MATERIAL FOR ANY ACTUAL, INDIRECT, CONSEQUENTIAL, SPECIAL OR OTHER DAMAGES ARISING FROM THE USE OF, OR INABILITY TO USE, THE MATERIAL, INCLUDING, BUT NOT LIMITED TO, ANY DAMAGES FOR LOST PROFITS.
ontology: PATHGO
owl-axioms: Prefix(owl:=<http://www.w3.org/2002/07/owl#>)\nPrefix(rdf:=<http://www.w3.org/1999/02/22-rdf-syntax-ns#>)\nPrefix(xml:=<http://www.w3.org/XML/1998/namespace>)\nPrefix(xsd:=<http://www.w3.org/2001/XMLSchema#>)\nPrefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)\n\n\nOntology(\nDeclaration(Class(<http://purl.obolibrary.org/obo/PATHGO_0000114>))\n############################\n#   Classes\n############################\n\n# Class: <http://purl.obolibrary.org/obo/PATHGO_0000114> (mechanism of pathogenicity)\n\nSubClassOf(<http://purl.obolibrary.org/obo/PATHGO_0000114> owl:Thing)\n\n\n)

[Term]
id: PATHGO:0000003
name: modulates ion channel activity
def: "A mechanism that disrupts cellular transport by modulating ion channel activity." []
xref: GO:0044069
xref: GO:0099106
is_a: PATHGO:0000167 ! disrupts cellular transport
property_value: editorialNote "direct action on ion channel (voltage or ligand gated) or ion pump," xsd:string

[Term]
id: PATHGO:0000006
name: modulates protein synthesis
def: "A mechanism that disrupts cellular metabolism by modulating protein synthesis." []
xref: GO:0044074
is_a: PATHGO:0000164 ! disrupts cellular metabolism

[Term]
id: PATHGO:0000007
name: disruption of neurotransmitter release
xref: GO:0044762
is_a: PATHGO:0000003 ! modulates ion channel activity
property_value: editorialNote "example agatoxin, omega conotoxin, dendrotoxin" xsd:string
property_value: editorialNote "inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved" xsd:string

[Term]
id: PATHGO:0000010
name: mediates non-specific T-cell activation
is_a: PATHGO:0000031 ! mediates non-productive immune system activation
property_value: editorialNote "example SEB (superantigens)" xsd:string

[Term]
id: PATHGO:0000016
name: modulates host immune function
def: "A mechanism that mediates pathogenicity by modulating host immune system components and processes.  Immune responses can be at the cellular level, or the organismal level." []
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000018
name: disrupts synaptic vesicle release
def: "A mechanism that prevents exocytosis by blocking release of synaptic vesicles." []
is_a: PATHGO:0000047 ! disrupts exocytosis
property_value: editorialNote "examples tetanus toxin (synaptobrevin cleavage; molecular target synaptobrevin), bot toxin (snare cleavage; molecular target snare protein)" xsd:string
property_value: editorialNote "inconsistent as a subclass as this is a specific case of disrupting exocytosis and not a mechanism by which exocytosis is disrupted" xsd:string

[Term]
id: PATHGO:0000021
name: disruption of post-synaptic membrane potential
is_a: PATHGO:0000003 ! modulates ion channel activity
property_value: editorialNote "example alpha bungarotoxin; cardiac glycosides (post syn calcium in muscle)" xsd:string
property_value: editorialNote "inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved" xsd:string

[Term]
id: PATHGO:0000023
name: disruption of action potential propagation
xref: GO:0044486
is_a: PATHGO:0000003 ! modulates ion channel activity
property_value: editorialNote "example tetrodotoxin, scorpion toxins" xsd:string
property_value: editorialNote "inconsistent as a subclass as this is a consequence of ion channel activity modulation; should be moved" xsd:string

[Term]
id: PATHGO:0000025
name: activates translation elongation factors
def: "A mechanism that modulates eukaryotic translation elongation factors by activating eukaryotic translation elongation factors." []
is_a: PATHGO:0000316 ! modulates eukaryotic translation elongation
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000028
name: modulates cytoskeleton in host cell
def: "A mechanism that modulates cytoskeleton in host cell by altering maintenance of cytoskeleton." []
xref: GO:0052039
is_a: PATHGO:0000166 ! disrupts cellular structure

[Term]
id: PATHGO:0000029
name: mediates membrane damage
def: "A mechanism that disrupts cellular structure by damaging the cell membrane." []
synonym: "lysis of host cells" RELATED []
xref: GO:0051673
xref: GO:0052025
is_a: PATHGO:0000166 ! disrupts cellular structure
property_value: editorialNote "consider vacuolization" xsd:string

[Term]
id: PATHGO:0000030
name: mediates ribosome inactivation
def: "A mechanism that modulates protein synthesis by ribosome inactivation." []
is_a: PATHGO:0000006 ! modulates protein synthesis
property_value: editorialNote "For example, Ricin toxin." xsd:string

[Term]
id: PATHGO:0000031
name: mediates non-productive immune system activation
is_a: PATHGO:0000016 ! modulates host immune function
property_value: editorialNote "evaluate class name and intent; determine how to capture superantigens\n\nEvaluate changing label to \"mediates immune system activation\"" xsd:string

[Term]
id: PATHGO:0000033
name: mediates pore formation
def: "A mechanism that mediates membrane damage by formation of pores." []
xref: GO:0044658
is_a: PATHGO:0000029 ! mediates membrane damage

[Term]
id: PATHGO:0000038
name: mediates adhesion
def: "A mechanism that enables adhesion and colonization by mediating attachment to cells or to surfaces, usually the host they are infecting or living in." []
synonym: "adhesin" RELATED []
xref: GO:0044406
is_a: PATHGO:0000147 ! enables adherence and colonization

[Term]
id: PATHGO:0000040
name: disrupts membrane potential
def: "A mechanism that mediates pathogenicity by disrupting the plasma membrane potential of host cells." []
xref: GO:0042391
xref: GO:0044662
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: editorialNote "Does this fit better anywhere else?" xsd:string

[Term]
id: PATHGO:0000047
name: disrupts exocytosis
def: "A mechanism that disrupts cellular transport by blocking exocytosis." []
xref: GO:0045920
is_a: PATHGO:0000167 ! disrupts cellular transport

[Term]
id: PATHGO:0000055
name: mediates membrane phospholipid cleavage
def: "A mechanism that mediates membrane damage by cleavage of membrane phospholipids." []
xref: GO:0009395
is_a: PATHGO:0000029 ! mediates membrane damage
property_value: editorialNote "evaluate for placement in invasion and dissemination" xsd:string

[Term]
id: PATHGO:0000058
name: mediates iron uptake
def: "A mechanism of nutrient avialability or uptake that involves acquisition of iron." []
is_a: PATHGO:0000113 ! mediates nutrient availability or uptake

[Term]
id: PATHGO:0000062
name: mediates biofilm formation
def: "A mechanism that enables adhesion and colonization by promoting synthesis of extracellular polymeric substances to form a biofilm." []
xref: GO:1900190
xref: GO:1900230
is_a: PATHGO:0000147 ! enables adherence and colonization
property_value: editorialNote "Process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. (Donlan, Rodney M. \"Biofilm formation: a clinically relevant microbiological process.\" Clinical Infectious Diseases 33.8 (2001): 1387-1392.)\n\nMechanism of colonization that involves synthesis of extracellular polymeric substances in a film." xsd:string

[Term]
id: PATHGO:0000066
name: mediates iron acquisition from host
def: "A mechanism of iron uptake that involves taking iron from a target cell." []
xref: GO:0044847
is_a: PATHGO:0000058 ! mediates iron uptake

[Term]
id: PATHGO:0000069
name: mediates host collagen binding
def: "A mechanism that mediates extracellular matrix binding by binding to collagen." []
xref: GO:0005518
is_a: PATHGO:0000099 ! mediates extracellular matrix binding

[Term]
id: PATHGO:0000072
name: mediates surface glycoprotein binding
def: "A mechanism that mediates cell surface binding by binding to glycoproteins (i.e. sugar-modified proteins) on the surface of a cell" []
xref: GO:0140081
is_a: PATHGO:0000211 ! mediates cell surface binding

[Term]
id: PATHGO:0000074
name: mediates induction of angiogenesis
def: "A mechanism that mediates proliferation and survival by stimulation of host blood vessel generation, or angiogenesis." []
xref: GO:0045766
is_a: PATHGO:0000150 ! mediates proliferation and survival
property_value: editorialNote "example VEGF\n\nevaluate proangiogenic response as a contribution to pathogenesis" xsd:string

[Term]
id: PATHGO:0000080
name: inhibits dendritic cell maturation
def: "A mechanism that mediates immune evasion and subversion by blocking immature dendritic immune cells from maturing into antigen-presenting, T cell activating cells." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion

[Term]
id: PATHGO:0000082
name: mediates peptide and protein degradation
def: "A mechanism of nutrient availability or uptake that involves peptide and protein degradation." []
xref: GO:0052014
is_a: PATHGO:0000113 ! mediates nutrient availability or uptake
property_value: editorialNote "overlaps with extracellular matrix destruction under invasion and dissemination" xsd:string

[Term]
id: PATHGO:0000084
name: inhibits lymphocyte proliferation
def: "A mechanism that mediates immune evasion and subversion by preventing lymphocytes from growing via cell division." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion

[Term]
id: PATHGO:0000085
name: mediates immune evasion and subversion
def: "A mechanism that mediates pathogenicity by modulating the availability or function of immune system components to evade or subvert host immune functions." []
is_a: PATHGO:0000016 ! modulates host immune function

[Term]
id: PATHGO:0000089
name: disrupts mitochondrial membrane potential
def: "A mechanism that disrupts cellular metabolism by disrupting the mitochondrial membrane potential." []
xref: GO:0033659
is_a: PATHGO:0000164 ! disrupts cellular metabolism
property_value: editorialNote "For example, during infection Listeria monocytogenes induces a loss of mitochondrial membrane potential by expressing listeriolysin O (LLO) which causes mitochondrial fission.  This change leads to reduced ATP production." xsd:string

[Term]
id: PATHGO:0000099
name: mediates extracellular matrix binding
def: "A mechanism that enables adhesion by mediating binding to extracellular matrix components such as collagen and fibronectin." []
xref: GO:0050840
is_a: PATHGO:0000038 ! mediates adhesion
property_value: editorialNote "Mechanism of adherence in which attachment occurs to components of the extracellular matrix as opposed to the target cell directly;\nelaborate subclasses\n\nCollagen binding protein and fibronectin binding protein are examples.  Including these as subclasses may be too granular." xsd:string

[Term]
id: PATHGO:0000100
name: mediates resistance to complement system
def: "A mechanism that mediates immune evasion and subversion by countering the effects of the complement system, a component of the innate immune system." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "resistance to complement-mediated killing\n\nexample:component 1 (C1) protease" xsd:string

[Term]
id: PATHGO:0000104
name: disrupts antimicrobial peptide binding
def: "A mechanism that mediates immune evasion and subversion by preventing antibacterial peptides from binding to their targets." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion

[Term]
id: PATHGO:0000108
name: mediates host actin polymerization inhibition
def: "A mechanism that modulates cytoskeleton in host cell by mediating inhibition of host actin polymerization." []
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell

[Term]
id: PATHGO:0000110
name: mediates secretion of protein effectors
def: "A mechanism that mediates pathogenicity by contributing to secretion of protein effectors from the bacterial cell into the extracellular environment or directly into the host cell." []
xref: GO:0044417
xref: GO:0050708
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: editorialNote "elaborate subclasses and align with determinant branch\n\nThe secretion pathways are typically described as \"types\" based on components/structures involved corresponding to variations on a few general strategies involving transport across inner membrane, transport across inner membrane followed by transport across outer membrane (two-step), transport across both membranes. Several types can also transport proteins directly across the host cell membrane to deliver effectors directly into cells\n\nType I- one step to extracellular\nType II- two step, first step is independent transport into periplasm\nType III- spans both membranes, injectosome into host cell\nType IV- spans both membranes, release of effectors into other cell (conjugation)\nType V-autotransporter in OM, first step is independent transport into periplasm\nType VI- spans both membranes, release into other cell\n\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804464/\nhttps://www.sciencedirect.com/science/article/pii/S0167488904000783\n\nEvaluate subclass naming/organization" xsd:string

[Term]
id: PATHGO:0000113
name: mediates nutrient availability or uptake
def: "A mechanism that promotes proliferation and survival by contributing to the availability and/or uptake of nutrients from host cells or the environment." []
xref: GO:0044002
is_a: PATHGO:0000150 ! mediates proliferation and survival
property_value: editorialNote "evaluate and modify subclasses to achieve consistent structure\n\nexamples may include: gelatinase, mucinase, sialidase, hyaluronidase - enzymes that are also associated with destruction of extracellular matrix, mucus, etc. to promote invasion and spread in the host \n\nsiderophore-chelate and sequester iron from host" xsd:string

[Term]
id: PATHGO:0000114
name: mechanism of pathogenicity
def: "Pathogenicity is the ability of microbes to have damaging effects on cells.  A mechanism of pathogenicity is a process that pathogens perform to have damaging effects on cells, and that specifically describes how that effect is exerted." []

[Term]
id: PATHGO:0000124
name: mediates iron acquisition from environment
def: "A mechanism of iron uptake that involves using iron in the environment." []
xref: GO:0005506
is_a: PATHGO:0000058 ! mediates iron uptake

[Term]
id: PATHGO:0000125
name: mediates desiccation resistance
def: "A mechanism that promotes proliferation and survival by enabling pathogens to survive periods without water, or drought-like conditions." []
xref: GO:0009269
is_a: PATHGO:0000150 ! mediates proliferation and survival

[Term]
id: PATHGO:0000132
name: inhibits DNA synthesis
def: "A mechanism that disrupts cellular metabolism by inhibiting DNA synthesis." []
xref: GO:2000279
is_a: PATHGO:0000164 ! disrupts cellular metabolism

[Term]
id: PATHGO:0000133
name: mediates host fibronectin binding
def: "A mechanism that mediates extracellular matrix binding by binding to fibronectin." []
xref: GO:0001968
is_a: PATHGO:0000099 ! mediates extracellular matrix binding

[Term]
id: PATHGO:0000135
name: mediates DNA cleavage
def: "A mechanism that mediates nutrient availability or uptake by mediating cleavage of host DNA." []
synonym: "deoxyribonuclease activity" RELATED []
xref: GO:0004536
xref: GO:0044003
xref: GO:0052013
xref: GO:1903626
is_a: PATHGO:0000113 ! mediates nutrient availability or uptake

[Term]
id: PATHGO:0000142
name: mediates acquisition of cholesterol from membrane
def: "A mechanism that mediates nutrient availability or uptake by taking cholesterol from the membranes of target cells." []
xref: GO:0051673
xref: GO:0052006
is_a: PATHGO:0000113 ! mediates nutrient availability or uptake

[Term]
id: PATHGO:0000147
name: enables adherence and colonization
def: "A mechanism that mediates pathogenicity by enabling pathogens to attach to host cells and establish growth." []
xref: BVF:0000002
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000149
name: mediates carbohydrate degradation
def: "A mechanism that mediates nutrient availability or uptake by mediating carbohydrate degradation." []
xref: GO:0052015
is_a: PATHGO:0000113 ! mediates nutrient availability or uptake

[Term]
id: PATHGO:0000150
name: mediates proliferation and survival
def: "A mechanism that mediates pathogenicity by allowing pathogens to grow and multiply, especially when environmental conditions are unfavorable, distinct from adherence and colonization." []
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: editorialNote "evaluate placement and provide examples" xsd:string

[Term]
id: PATHGO:0000152
name: induces cell cycle arrest
def: "A mechanism that modulates the cell cycle of a host cell by inducing cell cycle arrest" []
xref: GO:0007050
xref: GO:0044072
is_a: PATHGO:0000331 ! modulates cell cycle in host cell

[Term]
id: PATHGO:0000154
name: mediates manganese uptake
def: "A mechanism of nutrient availability or uptake that involves acquisition of manganese." []
xref: GO:0005384
is_a: PATHGO:0000113 ! mediates nutrient availability or uptake

[Term]
id: PATHGO:0000159
name: disrupts cellular adhesion
def: "A mechanism that mediates pathogenicity by disrupting the adhesion of cells to other cells and/or extracellular matrix components." []
xref: GO:0022408
xref: GO:0044067
xref: GO:0044364
xref: GO:1901889
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: editorialNote "evaluate for incorporation to invasion and dissemination\n\nelaborate subclasses" xsd:string

[Term]
id: PATHGO:0000161
name: disrupts mucosal barriers
def: "A mechanism that compromises the intestinal mucosal barrier, permitting microbial products and/or microbes entry into the body.  The intestinal mucosal barrier consists of the intestinal epithelial layer, plus additional physical, biochemical, and immunological components." []
synonym: "gastrointestinal barrier disruption" RELATED []
is_a: PATHGO:0000159 ! disrupts cellular adhesion
property_value: editorialNote "higher level process, not appropriate subclass; evaluate for removal or alternate placement; revise definition" xsd:string

[Term]
id: PATHGO:0000162
name: disrupts epithelial layers
def: "A mechanism that compromises epithelial cell layers, enabling increased permeation of biomolecules and/or bacterial invasion." []
is_a: PATHGO:0000159 ! disrupts cellular adhesion
property_value: editorialNote "higher level process, not appropriate subclass; evaluate for removal or alternate placement" xsd:string

[Term]
id: PATHGO:0000164
name: disrupts cellular metabolism
def: "A mechanism that mediates pathogenicity by disrupting cellular processes involved in the synthesis or breakdown of cellular constituents or production of energy." []
xref: GO:0044068
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000165
name: disrupts host cellular signaling
def: "A mechanism that mediates pathogenicity by disrupting host cellular signaling processes." []
xref: GO:0044501
xref: GO:0052027
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: editorialNote "refine/build out subclasses" xsd:string

[Term]
id: PATHGO:0000166
name: disrupts cellular structure
def: "A mechanism that mediates pathogenicity by disrupting the structural integrity of a cell." []
xref: GO:0052111
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000167
name: disrupts cellular transport
def: "A mechanism that mediates pathogenicity by disrupting transport of products into, out of, and within host cells." []
xref: GO:0044068
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: editorialNote "elaborate and restructure subclasses using a consistent organizational principle\n\nexample concepts to consider in determining organization:\nmembrane transport\nvesicular transport\nendocytosis/exocytosis\nactive/passive\nintracellular trafficking\nmicrotubule mediated transport" xsd:string

[Term]
id: PATHGO:0000168
name: mediates enzyme inhibition
def: "A mechanism that disrupts host cell signaling by inhibiting cellular enzymes. For inhibition of metabolic enzymes, see terms under 'disruption of cellular metabolism'." []
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: editorialNote "evaluate for placement and provide examples; disambiguate from mediates metabolic enzyme inhibition; revise definition" xsd:string

[Term]
id: PATHGO:0000170
name: disrupts cellular cAMP levels
def: "A mechanism that disrupts cellular metabolism by altering the levels of cyclic adenosine monophosphate (cyclic AMP, or cAMP) in cells.  Cyclic AMP is a second messenger molecule that regulates physiological processes in cells, through, for example, activation of intracellular signaling pathways." []
is_a: PATHGO:0000164 ! disrupts cellular metabolism
property_value: editorialNote "redundant to cellular signaling \"second messenger disruption\"; should be moved; evaluate subclasses" xsd:string

[Term]
id: PATHGO:0000171
name: mediates reactive oxygen species production
def: "A mechanism that disrupts cellular metabolism by mediating production of reactive oxygen species." []
xref: GO:2000379
is_a: PATHGO:0000164 ! disrupts cellular metabolism
property_value: editorialNote "should be moved as it is not a logical subclass for 'disrupts cellular metabolism'" xsd:string

[Term]
id: PATHGO:0000172
name: produces nitric oxide radicals
def: "A mechanism that mediates reactive oxygen species production by producing nitric oxide radicals, through activation of nitric oxide synthase or otherwise." []
xref: GO:0004517
is_a: PATHGO:0000171 ! mediates reactive oxygen species production
property_value: editorialNote "Nitric oxide radicals destroy iron-dependent enzymes, eventually inhibiting mitochondrial function and DNA synthesis in host cells.\n\nevaluate placement; not appropriate subclass" xsd:string

[Term]
id: PATHGO:0000173
name: modulates cAMP synthesis
def: "A mechanism that disrupts cellular cAMP levels through activation of the production or repression of the breakdown of cAMP." []
xref: GO:0051342
xref: GO:0075106
is_a: PATHGO:0000170 ! disrupts cellular cAMP levels

[Term]
id: PATHGO:0000174
name: regulates host cell adenylate cyclases/phosphodiesterases
xref: GO:0075106
is_a: PATHGO:0000170 ! disrupts cellular cAMP levels
property_value: editorialNote "evaluate for redundancy with \"modulates cAMP synthesis\"" xsd:string

[Term]
id: PATHGO:0000175
name: disrupts G-protein signaling pathways
def: "A mechanism that disprupts host cell signaling by interfering with host G-protien signaling pathways." []
is_a: PATHGO:0000165 ! disrupts host cellular signaling

[Term]
id: PATHGO:0000176
name: modulates receptor activity
def: "A mechanism that disrupts host cellular signaling by modulating receptor activity" []
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: editorialNote "Vague; Evaluate for removal" xsd:string

[Term]
id: PATHGO:0000177
name: modulates second messenger molecules
def: "A mechanism that disrupts host cellular signaling by modulating levels of second messenger molecules." []
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: editorialNote "cyclin-dependent kinase 1 inactivator; calcium- and calmodulin-dependent adenylate cyclase" xsd:string

[Term]
id: PATHGO:0000211
name: mediates cell surface binding
def: "A mechanism that mediates adhesion by enabling binding to cell surface receptors or components." []
xref: GO:0044650
is_a: PATHGO:0000038 ! mediates adhesion
property_value: editorialNote "elaborate subclasses\nsialyl Lewis x binding protein is an example" xsd:string

[Term]
id: PATHGO:0000212
name: mediates quorum sensing
def: "A mechanism that enables biofilm formation by contributing to quorum sensing." []
is_a: PATHGO:0000062 ! mediates biofilm formation

[Term]
id: PATHGO:0000213
name: inhibits platelet aggregation
xref: GO:0035893
is_a: PATHGO:0000159 ! disrupts cellular adhesion
property_value: editorialNote "for example: coagulation factor V protease, or disintegrins\n\nnot an appropriate subclass as this is a specific example, evaluate for class related to inhibition of integrin mediated adhesion \"disrupts \"integrin-dependent adhesion\"" xsd:string

[Term]
id: PATHGO:0000214
name: modifies host tight or adherens junctions
def: "A mechanism that disrupts cellular adhesion by modifying cellular junctional complexes, including tight junctions and/or adherens junctions." []
xref: GO:0098864
xref: GO:1903347
is_a: PATHGO:0000159 ! disrupts cellular adhesion
property_value: editorialNote "example: Clostridium perfringens type A toxin (targets claudins)  more info: https://doi.org/10.1016/j.bbamem.2008.10.028; https://www.ncbi.nlm.nih.gov/pubmed/11595640\n\nTerm changes suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000215
name: inhibits metabolic enzymes
def: "A mechanism that disrupts cellular metabolism by inhibiting metabolic enzymes." []
xref: GO:0004857
xref: GO:0052148
is_a: PATHGO:0000164 ! disrupts cellular metabolism
property_value: editorialNote "Provide examples." xsd:string

[Term]
id: PATHGO:0000216
name: mediates host actin depolymerization
def: "A mechanism that modulates cytoskeleton in host cell by mediating host actin depolymerization." []
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell

[Term]
id: PATHGO:0000217
name: mediates host actin crosslinking
def: "A mechanism that modulates cytoskeleton in host cell by promoting host actin crosslinking." []
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell

[Term]
id: PATHGO:0000220
name: suppresses inflammatory cytokine release
def: "A mechanism that mediates immune evasion and subversion by suppressing release of inflammatory cytokines." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion

[Term]
id: PATHGO:0000221
name: mediates microtubule stabilization
def: "A mechanism that modulates cytoskeleton in host cell by mediating microtubule stabilization." []
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell
property_value: editorialNote https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625037/ xsd:string

[Term]
id: PATHGO:0000222
name: mediates microtubule destabilization
def: "A mechanism that modulates cytoskeleton in host cell by mediating microtubule destabilization." []
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell
property_value: editorialNote https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625037/ xsd:string

[Term]
id: PATHGO:0000225
name: contributes to adhesion appendage formation
def: "A mechanism that mediates adhesion by contributing to the formation of an adhesion appendage." []
is_a: PATHGO:0000038 ! mediates adhesion
property_value: editorialNote "Fimbriae proteins/subunits are examples.  \n\nIntended to capture components that are not directly adhesins, but this class may not be structurally consistent.\n\nNo term in GO for describing \"scaffolding\" of a adhesion molecule" xsd:string

[Term]
id: PATHGO:0000226
name: disrupts extracellular matrix
def: "A mechanism that mediates invasion by disrupting extracellular matrix components." []
is_a: PATHGO:0000235 ! mediates host cell invasion
property_value: editorialNote "gelatinase, mucinase, sialidase, hyaluronidase, etc." xsd:string

[Term]
id: PATHGO:0000228
name: disrupts second messenger levels
def: "A mechanism that disrupts host cellular signaling by modulating levels of second messenger molecules." []
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: editorialNote "examples: cyclin-dependent kinase 1 inactivator; calcium- and calmodulin-dependent adenylate cyclase" xsd:string

[Term]
id: PATHGO:0000229
name: mediates quorum sensing autoinducer production
def: "A mechanism that contributes to quorum sensing by promoting production of autoinducer molecules." []
synonym: "autoinducer synthase" RELATED []
is_a: PATHGO:0000212 ! mediates quorum sensing

[Term]
id: PATHGO:0000230
name: mediates free radical detoxification
def: "A mechanism that mediates immune evasion and subversion by detoxifying free radicals." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion

[Term]
id: PATHGO:0000231
name: inhibits opsonization
def: "A mechanism that inhibits phagocytosis by inhibiting opsonization, the process by which particles are targeted for phagocytosis." []
is_a: PATHGO:0000232 ! inhibits phagocytosis
property_value: editorialNote "If a mechanism inhibits opsonization, which is the process of marking foreign particles for phagocytosis by marking them with opsonins, then it necessarily also inhibits phagocytosis." xsd:string

[Term]
id: PATHGO:0000232
name: inhibits phagocytosis
def: "A mechanism that mediates immune evasion and subversion by inhibiting phagocytosis by immune cells like macrophages." []
synonym: "antiphagocytosis" RELATED []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion

[Term]
id: PATHGO:0000233
name: disrupts host toll-like receptor signaling
def: "A mechanism that mediates immune evasion and subversion by disrupting toll-like receptor signaling." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "adaptor protein degradation activator; research and add others" xsd:string

[Term]
id: PATHGO:0000234
name: mediates integrin binding
comment: A mechanism that mediates cell surface binding through integrins.
xref: GO:0005178
is_a: PATHGO:0000211 ! mediates cell surface binding
property_value: editorialNote "integrin α2β1 binding protein and integrin αMβ2 binding protein are examples that may be too granular to include" xsd:string

[Term]
id: PATHGO:0000235
name: mediates host cell invasion
def: "A mechanism that mediates pathogenicity by facilitating movement into host cells." []
synonym: "invasin" RELATED []
xref: GO:0044409
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000236
name: modulates host cell endomembrane dynamics
def: "A mechanism that mediates pathogenicity by manipulating host cell endomembrane dynamics." []
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000237
name: mediates escape from host phagosome
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: definition "A mechanism that modulates host cell endomembrane dynamics by mediating escape from host phagosome." xsd:string

[Term]
id: PATHGO:0000238
name: mediates evasion of lysosome lysis
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: definition "A mechanism that modulates host cell endomembrane dynamics by mediating evasion of lysosome lysis." xsd:string

[Term]
id: PATHGO:0000239
name: disrupts phagolysosome fusion
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: definition "A mechanism that modulates host cell endomembrane dynamics by disrupting phagolysosome fusion." xsd:string

[Term]
id: PATHGO:0000240
name: disrupts phagosome acidification
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: definition "A mechanism that modulates host cell endomembrane dynamics by disrupting phagosome acidification." xsd:string

[Term]
id: PATHGO:0000241
name: disrupts phagosome maturation in host cell
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: definition "A mechanism that modulates host cell endomembrane dynamics by disrupting phagosome maturation in the host cell." xsd:string

[Term]
id: PATHGO:0000242
name: mediates host vitronectin binding
def: "A mechanism that mediates extracellular matrix binding by adhering specifically to vitronectin.  Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix." []
is_a: PATHGO:0000099 ! mediates extracellular matrix binding
property_value: editorialNote "For example, Candida albicans uses its cell surface protein Gpm1 to attach to human endothelial cells through its interaction with vitronectin (PMID: 24625558). \n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000244
name: represses translation elongation factors
is_a: PATHGO:0000316 ! modulates eukaryotic translation elongation
property_value: definition "A mechanism that modulates eukaryotic translation elongation factors by repression of eukaryotic translation elongation factors." xsd:string
property_value: editorialNote "examples Legionella glycosylating toxins and SidI, SARS-CoV N protein" xsd:string
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000246
name: disrupts endosomal vesicle fusion
def: "A mechanism that disrupts the host cell endomembrane system by disrupting fusion between vesicles and other cellular compartments that occur as part of normal host function." []
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000251
name: mediates dissemination
def: "A mechanism that mediates pathogenicity by enabling pathogens to spread through host tissues." []
synonym: "mediates spreading" RELATED []
xref: GO:0044000
is_a: PATHGO:0000114 ! mechanism of pathogenicity

[Term]
id: PATHGO:0000253
name: mediates host barrier traversal
def: "A mechanism that mediates dissemination by promoting traversal of host barrier layers." []
xref: GO:0044001
is_a: PATHGO:0000251 ! mediates dissemination
property_value: editorialNote "[Examples Macrophage infectivity potentiator from Legionella; Exylysin from Pseudomonas; Pseudomonas exotoxin S; Pseudomonas exotoxin T; Shigella extracellular protease]\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000255
name: mediates guanine exchange for host small GTPase
def: "A mechanism that disrupts host cellular signaling by mediating guanine exchange for a host small, monomeric, GTPase (Ras, Rho, Rab, etc.) inducing the expulsion of a bound GDP for a fresh GTP and thereby activating the protein." []
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: editorialNote "Shouldn't this term live under 'disrupts G-protein signaling pathways'?\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000257
name: mediates host immunoglobulin neutralization
def: "A mechanism that mediates immune evasion and subversion by proteolytic destruction of host immunoglobulins." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "https://orcid.org/0000-0002-5702-4690\n\n[Examples of bacterial proteases: IgA1P, IdeS, EndoS, ZmpC from Streptococcus; InvD from Yersinia pseudotuberculosis; and BatB from Bordetella]" xsd:string

[Term]
id: PATHGO:0000259
name: modifies host cell focal adhesions
xref: GO:0051895
is_a: PATHGO:0000159 ! disrupts cellular adhesion
property_value: definition "A mechanism that disrupts cellular adhesion by modifying focal adhesions of host cells." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000260
name: mediates host actin rearrangement
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell
property_value: definition "A mechanism that modulates cytoskeleton in host cell by mediating host actin rearrangement" xsd:string
property_value: editorialNote "Note, in some cases, the extent of actin rearrangement is sufficient to allow for parasitic invasion of a host cell.\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000261
name: mediates host actin polymerization
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell
property_value: definition "A mechanism that modulates cytoskeleton in host cell by mediating host actin polymerization" xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000265
name: modulates eukaryotic translation initiation
def: "A mechanism that modulates protein synthesis by modulating eukaryotic translation initiation." []
is_a: PATHGO:0000006 ! modulates protein synthesis
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000266
name: activates translation initiation factors
def: "A mechanism that modulates eukaryotic translation initiation by activating eukaryotic translation initiation factors." []
is_a: PATHGO:0000265 ! modulates eukaryotic translation initiation
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000267
name: represses translation initiation factors
def: "A mechanism that modulates eukaryotic translation initiation by repressing eukaryotic translation initation factors." []
is_a: PATHGO:0000265 ! modulates eukaryotic translation initiation
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000268
name: mediates resistance to host neutrophil extracellular traps (NETs)
def: "A mechanism that mediates immune evasion and subversion by countering host neutrophil extracellular traps (NETs), which contain processed nuclear DNA that can trap and kill pathogens." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "[Examples: Nuc from N. gonorrhoeae; EndA, Sda1, SpnA from Streptococcus]\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000271
name: mediates resistance to host oxidative killing
def: "A mechanism that mediates immune evasion and subversion by disrupting host oxidative killing through interference with the signaling that triggers production of host reactive oxygen species (ROS) or nitric oxide (NO) or by directly inactivating host ROS or NO." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "Attribution: https://orcid.org/0000-0002-5702-4690" xsd:string

[Term]
id: PATHGO:0000273
name: mediates host glycosaminoglycan- or proteoglycan-binding
xref: GO:0005539\,GO\:0043394
is_a: PATHGO:0000099 ! mediates extracellular matrix binding
property_value: definition "A mechanism that mediates extracellular matrix binding by adherance to glycosaminoglycans or proteoglycans in the host extracellular matrix." xsd:string

[Term]
id: PATHGO:0000275
name: mediates host laminin binding
xref: GO:0043236
is_a: PATHGO:0000099 ! mediates extracellular matrix binding
property_value: definition "A mechanism that mediates extracellular matrix binding by adherence to laminin in the host extracellular matrix." xsd:string

[Term]
id: PATHGO:0000278
name: stimulates small GTPase activity
synonym: "GTPase activating protein (GAP)" RELATED []
is_a: PATHGO:0000175 ! disrupts G-protein signaling pathways
property_value: definition "A mechanism that disrupts G-protein signaling pathways by stimulating small, monomeric host GTPase to hydrolyze bound GTP." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000279
name: stimulates heterotrimeric GTPase activity
is_a: PATHGO:0000175 ! disrupts G-protein signaling pathways
property_value: definition "A mechanism that disrupts G-protein signaling pathways by stimulating host heterotrimeric GTPase to hydrolyze bound GTP." xsd:string

[Term]
id: PATHGO:0000280
name: mediates microtubule rearrangement
is_a: PATHGO:0000028 ! modulates cytoskeleton in host cell
property_value: definition "A mechanism that modulates cytoskeleton in host cell by mediating microtubule rearrangement." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000284
name: mediates cholesterol binding
xref: GO:0015485
is_a: PATHGO:0000211 ! mediates cell surface binding
property_value: definition "A mechanism that mediates cell surface binding by enabling binding to host cell surface cholesterol." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000285
name: mediates carbohydrate-derivative binding
xref: GO:0097367
is_a: PATHGO:0000211 ! mediates cell surface binding
property_value: definition "A mechanism that mediates cell surface binding by enabling binding to host cell surface carbohydrate components of glycolipids or glycoproteins." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000289
name: modulates host MAPK signaling
def: "A mechanism that disrupts host cellular signaling by modulating host MAPK signaling." []
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000290
name: disrupts host MAPK signaling
def: "A mechansim that modulates host MAPK signaling by disrupting host MAPK signaling through downregulation of host MAPK signaling by either directly acting on a member of the p38MAPK, JNK, or ERK1/2 pathways or altering the abundance of at least one member of those signaling pathways." []
is_a: PATHGO:0000289 ! modulates host MAPK signaling
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000291
name: enhances host MAPK signaling
def: "A mechanism that modulates host MAPK signaling by enhancing host MAPK signaling through direct action on a member of the p38MAPK, JNK, or ERK1/2 pathways or alteration of the abundance of at least one member of those signaling pathways." []
is_a: PATHGO:0000289 ! modulates host MAPK signaling
property_value: editorialNote "Example includes GRA24 from Toxoplasma gondii. It targets host p38 alpha which leads to autophosphorylation and activation. p38 activation leads to the upregulation of proinflammatory cytokine production.\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000292
name: disrupts host TNFR signaling
def: "A mechanism that mediates immune evasion and subversion by affecting the activity, abundance, or availability of host tumor necrosis factor receptor (TNFR) ligands or by inhibiting TNFR signaling by binding directly to the receptor." []
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000294
name: modulates host NF-kappaB signaling
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by modulating host NF-kappaB signaling." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000295
name: disrupts host NF-kappaB signaling
is_a: PATHGO:0000294 ! modulates host NF-kappaB signaling
property_value: definition "A mechanism that modulates host NF-kappaB signaling by disrupting host NF-kappaB signaling so that the effector subunit is not able to initiate transcription in the nucleus." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000296
name: enhances host NF-kappaB signaling
is_a: PATHGO:0000294 ! modulates host NF-kappaB signaling
property_value: definition "A mechanism that modulates host NF-kappaB signaling by enhancing host NF-kappaB signaling by promoting activation." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000300
name: disrupts host STING signaling
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by disrupting host stimulator of interferon genes (STING) signaling via targeting STING directly or affecting a protein proximal to STING that interferes with the proper recognition of pathogen activity." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000302
name: disrupts host JAK-STAT signaling
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by disrupting host Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling via targeting a sequence proximal to JAKs, STATs, protein inhibitors of activated STATs (PIAS), or suppressors of cytokine signaling (SOCS)." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000304
name: disrupts host PKR activity
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by disrupting host protein kinase R (PKR) activity via pre-emptively binding pathogen dsRNA to sequester it from PKR, interfering with the phosphorylation of PKR by proximal effectors, or binding PKR directly." xsd:string
property_value: definition "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000306
name: disrupts host RIG-1 signaling
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by disrupting host cytosolic signaling proximal to the pattern recognition receptor retinoic acid-inducible gene I (RIG-1) via altering the ubiquitination of RIG-1, downregulating RIG-1 activity, reducing RIG-1 abundance, or impeding the interaction of RIG-1 with downstream effectors such as MAVS." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000308
name: disrupts host antigen presentation
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: definition "A mechanism that mediates immune evasion and subversion by disrupting host antigen presentation via inhibiting MHC I/II production or display, manipulating production or display of the antigen or epitope by altering activity of the proteasome or the TAP complex, or specifically targeting a particular parasite antigen for destruction." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000310
name: inhibits host cytokine activity
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: definition "A mechanism that mediates immune evasion and subversion by inhibiting host cytokine activity via sequestering or destroying the cytokine so it is not available to participate in host signaling." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000312
name: enables pathogen nucleic acid concealment
is_a: PATHGO:0000085 ! mediates immune evasion and subversion
property_value: editorialNote "A mechanism that mediates immune evasion and subversion by enabling pathogen nucleic acid concealment by the viral protein (typically carried out by dsRNA nucleic acid binding) for evasion of host pathogen recognition receptors." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000314
name: modulates host TRAF signaling
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by modulating host TNF receptor-associated factor (TRAF) signaling." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000316
name: modulates eukaryotic translation elongation
def: "A mechanism that modulates protein synthesis by modulating eukaryotic translation elongation." []
xref: GO:0003746
is_a: PATHGO:0000006 ! modulates protein synthesis
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000321
name: modulates endosomal vesicle trafficking
def: "A mechanism that disrupts the host cell endomembrane system by modulating trafficking of vesicles to other cellular compartments that occur as part of normal host function." []
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: editorialNote "Many parasite proteins, particularly from intracellular bacteria pathogens, inhibit or redirect host vesicle trafficking.\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000322
name: mediates resistance to antibiotics
def: "A mechanism that mediates proliferation and survival by mediating resistance to antibiotics." []
xref: ARO:1000001
xref: GO:0046677
is_a: PATHGO:0000150 ! mediates proliferation and survival
property_value: editorialNote "No subclasses.  Antibiotic resistance is well-covered by the Comprehensive Antibiotic Resistance Database (CARD) Ontology." xsd:string

[Term]
id: PATHGO:0000323
name: disrupts intracellular transport
def: "A mechanism that disrupts cellular transport by disrupting intracellular transport" []
xref: GO:0052038
xref: GO:1990215
is_a: PATHGO:0000167 ! disrupts cellular transport

[Term]
id: PATHGO:0000325
name: modulates ubiquitin dynamics in host cell
def: "A mechanism that disrupts cellular metabolism through modulation or redirection of E3 ubiquitin ligase, E3 ubiquitin ligase activity, E2 enzymes, or removal of ubiquitin from a target protein." []
is_a: PATHGO:0000164 ! disrupts cellular metabolism
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000326
name: modulates transcription in host cell
def: "A mechanism that disrupts cellular metabolism by modulating transcription in the host cell." []
xref: GO:0052018
is_a: PATHGO:0000164 ! disrupts cellular metabolism
property_value: editorialNote https://orcid.org/0000-0002-5702-4690 xsd:string

[Term]
id: PATHGO:0000328
name: modulates host small GTPase dynamics
is_a: PATHGO:0000165 ! disrupts host cellular signaling
property_value: definition "A mechanism that disrupts host cellular signaling by modulating host small GTPase dynamics. This manipulation can occur through direct binding of host small GTPases or by alteration of the activity or abundance of the proximal effectors of small GTPases, including GTPase activating proteins (GAPs), guanine exchange factors (GEFs), or guanine dissociation inhibitors (GDIs)." xsd:string
property_value: editorialNote "Shouldn't this term live under 'disrupts G-protein signaling pathways'?\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000331
name: modulates cell cycle in host cell
xref: GO:0044071
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: definition "A mechanism that mediates pathogenicity by modulating the cell cycle of a host cell." xsd:string
property_value: editorialNote "Elaborate subclasses" xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000332
name: modulates apoptosis in host cell
xref: GO:0052150
is_a: PATHGO:0000114 ! mechanism of pathogenicity
property_value: definition "A mechanism that mediates pathogenicity by modulating apoptosis in host cells. Gene products produced by pathogenic microbes may induce or prevent apoptosis to enable growth inside the host." xsd:string
property_value: editorialNote "Evaluate for placement in proliferation and survival" xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000334
name: suppresses apoptosis in host cell
xref: GO:0033668
is_a: PATHGO:0000332 ! modulates apoptosis in host cell
property_value: definition "A mechanism that modulates apoptosis in the host cell by suppressing apoptosis in the host cell." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000335
name: induces apoptosis in host cell
xref: GO:0052151
is_a: PATHGO:0000332 ! modulates apoptosis in host cell
property_value: definition "A mechanism that modulates apoptosis in the host cell by inducing apoptosis in the host cell." xsd:string
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000339
name: direct host complement inactivation
is_a: PATHGO:0000100 ! mediates resistance to complement system
property_value: definition "A mechanism that mediates resistance to the host complement system by direct host complement inactivation via enzymatic activity that inheres in the parasite sequence." xsd:string
property_value: editorialNote "Term suggested by Gene Goldbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000341
name: indirect host complement inactivation
is_a: PATHGO:0000100 ! mediates resistance to complement system
property_value: definition "A mechanism that mediates resistance to the host complement system by indirect host complement inactivation via recruiting a host enzyme, typically a proteinase, to the parasite surface." xsd:string
property_value: editorialNote "Term suggested by Gene Goldbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000343
name: mediates pathogen vacuole formation/maintenance
def: "A mechanism that modulates host cell endomembrane dynamics by contributing to the formation and/or maintenance of the vacuole." []
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000345
name: inhibits autophagosome formation in host cell
def: "A mechanism that modulates host cell endomembrane dynamics by inhibiting autophagosome formation." []
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000347
name: modulates autophagy or xenophagy in host cell
def: "A mechanism that modulates host endomembrane dynamics by modulating autophagy or xenophagy." []
is_a: PATHGO:0000236 ! modulates host cell endomembrane dynamics
property_value: editorialNote "Term suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Term]
id: PATHGO:0000349
name: mediates type VII secretion
is_a: PATHGO:0000110 ! mediates secretion of protein effectors
property_value: definition "A mechanism that mediates secretion of protein effectors as part of a type VII secretion system that can mediate the entry of bacterial effectors into the host cell." xsd:string
property_value: editorialNote "Do we want to have subclasses for every single type of secretion system?\n\nTerm suggested by Gene Godbold (https://orcid.org/0000-0002-5702-4690)" xsd:string

[Typedef]
id: PATHGO:0000243
name: participates_in
is_inverse_functional: true