diff --git a/core-server/src/main/java/org/glassfish/jersey/server/ApplicationHandler.java b/core-server/src/main/java/org/glassfish/jersey/server/ApplicationHandler.java
index 315cb181d9..5191ee0e78 100644
--- a/core-server/src/main/java/org/glassfish/jersey/server/ApplicationHandler.java
+++ b/core-server/src/main/java/org/glassfish/jersey/server/ApplicationHandler.java
@@ -134,6 +134,8 @@
 import org.glassfish.hk2.utilities.binding.AbstractBinder;
 import org.glassfish.hk2.utilities.binding.ScopedBindingBuilder;
 
+import org.jvnet.hk2.external.runtime.ServiceLocatorRuntimeBean;
+
 import jersey.repackaged.com.google.common.base.Function;
 import jersey.repackaged.com.google.common.base.Predicate;
 import jersey.repackaged.com.google.common.collect.Collections2;
@@ -594,9 +596,22 @@ private ServerRuntime initialize(Iterable<ComponentProvider> componentProviders)
                 .to(routingStage)
                 .to(resourceFilteringStage)
                 .build(Routing.matchedEndpointExtractor());
+
         final ServerRuntime serverRuntime = locator.createAndInitialize(ServerRuntime.Builder.class)
                 .build(rootStage, compositeListener, processingProviders);
 
+        // clear HK2 caches
+        final ServiceLocatorRuntimeBean serviceLocatorRuntimeBean = locator.getService(ServiceLocatorRuntimeBean.class);
+        if (serviceLocatorRuntimeBean != null) {
+            if (LOGGER.isLoggable(Level.FINE)) {
+                LOGGER.fine(LocalizationMessages.CLEARING_HK_2_CACHE(
+                        serviceLocatorRuntimeBean.getServiceCacheSize(),
+                        serviceLocatorRuntimeBean.getReflectionCacheSize()));
+            }
+            serviceLocatorRuntimeBean.clearReflectionCache();
+            serviceLocatorRuntimeBean.clearServiceCache();
+        }
+
         // Inject instances.
         for (final Object instance : componentBag.getInstances(ComponentBag.EXCLUDE_META_PROVIDERS)) {
             locator.inject(instance);
diff --git a/core-server/src/main/resources/org/glassfish/jersey/server/internal/localization.properties b/core-server/src/main/resources/org/glassfish/jersey/server/internal/localization.properties
index 3a5ab34501..a4676a7114 100644
--- a/core-server/src/main/resources/org/glassfish/jersey/server/internal/localization.properties
+++ b/core-server/src/main/resources/org/glassfish/jersey/server/internal/localization.properties
@@ -130,6 +130,7 @@ form.param.method.error=The "@FormParam" is utilized when the request method is
 get.consumes.entity=A HTTP GET method, {0}, should not consume any entity.
 get.consumes.form.param=A HTTP GET method, {0}, should not consume any form parameter.
 get.returns.void=A HTTP GET method, {0}, returns a void type. It can be intentional and perfectly fine, but it is a little uncommon that GET method returns always "204 No Content".
+clearing.hk2.cache=Clearing Jersey HK2 caches. Service cache size: {0}, reflection cache size: {1}.
 chunked.output.closed=This chunked output has been closed.
 illegal.client.config.class.property.value="{0}" property value ({1}) does not represent a valid client configuration class. Falling back to "{2}".
 init.msg=Initiating Jersey application, version {0}...