Sub article elements - peer review components published with the articles
The decision letter and response from the peer review process are published at the end of the article as sub article components. Can contain figures, tables and videos that are not part of the main article.
<sub-article article-type="article-commentary" id="SA1">
<front-stub>
<article-id pub-id-type="doi">10.7554/eLife.00013.037</article-id>
<title-group>
<article-title>Decision letter</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="editor">
<name>
<surname>Sneden</surname>
<given-names>Christopher</given-names>
</name>
<role>Reviewing editor</role>
<aff>
<institution>Pediatric Dengue Vaccine Initiative</institution>,
<country>United States</country>
</aff>
</contrib>
</contrib-group>
<contrib-group>
<contrib contrib-type="reviewer" id="author-34">
<name>
<surname>Harrison</surname>
<given-names>Melissa</given-names>
</name>
<role>Reviewer</role>
<aff>
<institution>Pediatric Dengue Vaccine Initiative</institution>,
<country>United States</country>
</aff>
</contrib>
</contrib-group>
<contrib-group>
<contrib contrib-type="reviewer" id="author-35">
<name>
<surname>Roderick</surname>
<given-names>Sian</given-names>
</name>
<role>Reviewer</role>
<aff>
<institution>Pediatric Dengue Vaccine Initiative</institution>,
<country>United States</country>
</aff>
</contrib>
</contrib-group>
</front-stub>
<body>
<boxed-text>
<p>eLife posts the editorial decision letter and author response on a selection of
the published articles (subject to the approval of the authors). An edited
version of the letter sent to the authors after peer review is shown, indicating
the substantive concerns or comments; minor concerns are not usually shown.
Reviewers have the opportunity to discuss the decision before the letter is sent
(see <ext-link ext-link-type="uri"
xlink:href="http://elifesciences.org/review-process">review
process</ext-link>). Similarly, the author response typically shows only
responses to the major concerns raised by the reviewers.</p>
</boxed-text>
<p>Text text text</p>
</body>
</sub-article>
<sub-article article-type="reply" id="SA2">
<front-stub>
<article-id pub-id-type="doi">10.7554/eLife.00013.037</article-id>
<title-group>
<article-title>Author response</article-title>
</title-group>
</front-stub>
<body>
<p>Text text text</p>
<italic>2) An expanded discussion of the difference in activity between purified
RIF-1 vs. the sphingolipid-enriched fraction (<xref ref-type="table" rid="tbl2"
>Table 2</xref>). On p. 8, paragraph 1, we clarify that the difference in
activity could be due either to delivery issues (i.e. a requirement for RIF-1 to
be delivered in the context of the bacterial membrane) or to the absence of
other currently unidentified A. machipongonensis molecules that either amplify
RIF-1 signaling or might independently induce colony development in S. rosetta
(<xref ref-type="fig" rid="fig5">Author response image 1</xref>). In
addition, on p. 9 we state that “We hypothesize that RIF-1 may be
released into the environment in membrane vesicles, which have been described in
Gram-negative bacteria and Bacteroidetes (50,51) and that additional membrane
constituents might be required for the full potency of RIF-1.</italic>”
<fig id="fig5" position="float">
<object-id pub-id-type="doi">10.7554/eLife.00013.038</object-id>
<label>Author response image 1</label>
<caption>
<title>Correlation between mean Voxel Number and resulting mean Decoding
Accuracy (shown for each ROI (N=13) and each of the three pair-wise
comparisons for the Plan-Epoch).</title>
<p>Pearson correlation between Voxel Number and Hand Plan Epoch decoding
accuracies (red diamond symbols): r<sup>2</sup>=0.108,
p=0.272; Pearson Correlation between Voxel Number and Tool Plan
Epoch decoding accuracies (blue square symbols):
r<sup>2</sup>=0.025, p=0.602; Pearson Correlation between
Voxel Number and Across-Effector Plan Epoch decoding accuracies (purple
triangle symbols): r<sup>2</sup>=0.026, p=0.598.</p>
<p>
<bold>DOI:</bold>
<ext-link ext-link-type="doi" xlink:href="10.7554/eLife.00013.038"
>http://dx.doi.org/10.7554/eLife.00013.038</ext-link>
</p>
</caption>
<graphic xlink:href="elife00013f005" xmlns:xlink="http://www.w3.org/1999/xlink"
/>
</fig>
</p>
<p>
<italic>3) A more detailed discussion of future directions for this research,
including (as pointed out by the reviewers) the need to determine the
three-dimensional structure of RIF-1 (p. 9, <xref ref-type="fig" rid="sfig1"
>Figure 1—figure supplement 1</xref>). Note that defining the
stereochemistry will require synthesizing several different possible
stereoisomers of RIF-1, and that there are no published total syntheses of any
sulfonolipids in the literature (<xref ref-type="table" rid="tbl4">Author
response table 1</xref>)</italic>.
<table-wrap id="tbl4" position="float">
<object-id pub-id-type="doi">10.7554/eLife.00013.039</object-id>
<label>Author response table 1.</label>
<caption>
<p>GC-MS analysis of cuticular hydrocarbon extracts from control,
<italic>miR-124</italic> mutant, rescued mutants, and
<italic>miR-124>tra-RNAi</italic> males</p>
<p>
<bold>DOI:</bold>
<ext-link ext-link-type="doi" xlink:href="10.7554/eLife.00013.039"
>http://dx.doi.org/10.7554/eLife.00013.039</ext-link>
</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th>Compound and elemental composition</th>
<th>Control (n = 3)</th>
<th>
<italic>mir-124</italic> mutant (n = 3)</th>
<th>Rescued mutant (n = 3)</th>
<th>mir-124> tra-RNAi (n = 2)</th>
</tr>
</thead>
<tbody>
<tr>
<td>C21:0 (nC21)</td>
<td align="char" char="plusmn">0.28 ± 0.1</td>
<td align="char" char="plusmn">0.21 ± 0.01</td>
<td align="char" char="plusmn">0.51 ± 0.03</td>
<td align="char" char="plusmn">0.35 ± 0.04</td>
</tr>
<tr>
<td>C22:1</td>
<td align="char" char="plusmn">0.22 ± 0.02</td>
<td align="char" char="plusmn">0.24 ± 0.01</td>
<td align="char" char="plusmn">0.31 ± 0.02</td>
<td align="char" char="plusmn">0.34 ± 0.03</td>
</tr>
<tr>
<td>cVA (cis-vaccenyl acetate)</td>
<td align="char" char="plusmn">3.86 ± 0.43</td>
<td align="char" char="plusmn">0.48 ±
0.04***</td>
<td align="char" char="plusmn">2.57 ± 0.47*</td>
<td align="char" char="plusmn">2.09 ± 0.23*</td>
</tr>
<tr>
<td>C22:0</td>
<td align="char" char="plusmn">0.61 ± 0.03</td>
<td align="char" char="plusmn">0.60 ± 0.01</td>
<td align="char" char="plusmn">0.87 ± 0.05</td>
<td align="char" char="plusmn">0.70 ± 0.05</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
</body>
</sub-article>
</article>