From a146fd6d4ccdf051d4f5dcd87308996e86bf8cec Mon Sep 17 00:00:00 2001
From: jvfe <jvfecav@gmail.com>
Date: Mon, 26 Sep 2022 16:03:35 -0300
Subject: [PATCH 01/24] Add script to get biotypes for DGE/DTE

---
 .gitignore                   |  3 +-
 scripts/summarise_biotypes.R | 82 ++++++++++++++++++++++++++++++++++++
 2 files changed, 84 insertions(+), 1 deletion(-)
 create mode 100644 scripts/summarise_biotypes.R

diff --git a/.gitignore b/.gitignore
index dbe2dcc..4ccc2ae 100644
--- a/.gitignore
+++ b/.gitignore
@@ -19,4 +19,5 @@
 renv/*
 slurm*
 run*
-data/*
\ No newline at end of file
+data/*
+results/diff_exp/*
diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
new file mode 100644
index 0000000..28cf2f9
--- /dev/null
+++ b/scripts/summarise_biotypes.R
@@ -0,0 +1,82 @@
+library(dplyr)
+library(purrr)
+library(ggplot2)
+library(rtracklayer)
+library(GenomicFeatures)
+
+# 1. Carregando GTF ---------------------------------------
+gtf <- "./data/Homo_sapiens.GRCh38.97.chr_patch_hapl_scaff.gtf.gz"
+
+gtf_data <- import(gtf)
+
+# 2. Lendo DGE/DTE e pegando os biotipos ---------------------------------------
+load("./results/diff_exp/diff_df.rda")
+
+dge_genes <- diff_df %>%
+  filter(type == "DGE")
+
+# 2.1. Pegando biotipo dos DGE ---------------------------------------
+dge_w_biotype <- gtf_data[, c("gene_id", "gene_biotype")] %>%
+  as.data.frame() %>%
+  filter(gene_id %in% dge_genes$gene) %>%
+  dplyr::select(gene_id, gene_biotype) %>%
+  right_join(dge_genes, by = c("gene_id" = "gene")) %>%
+  distinct() %>% 
+  dplyr::select(gene_id, gene_biotype, group)
+
+readr::write_csv(dge_w_biotype, "results/diff_exp/dge_w_biotype.csv")
+
+# 2.2. Pegando biotipo dos DTE ---------------------------------------
+load("./results/diff_exp/diff_tx_corrected.rda")
+
+dte_genes <- df_res_padj_tx %>%
+  dplyr::select(txID, transcript, group) %>%
+  filter(transcript < 0.01)
+
+dte_w_biotype <-
+  gtf_data[, c("transcript_id", "transcript_biotype")] %>%
+  as.data.frame() %>%
+  filter(transcript_id %in% dte_genes$txID) %>%
+  dplyr::select(transcript_id, transcript_biotype) %>%
+  right_join(dte_genes, by = c("transcript_id" = "txID")) %>%
+  distinct() %>% 
+  dplyr::select(transcript_id, transcript_biotype, group)
+
+readr::write_csv(dte_w_biotype, "results/diff_exp/dte_w_biotype.csv")
+
+# 2.3. Pegando biotipo dos DTU ---------------------------------------
+
+
+
+# 3. Plotando as porcentagens ---------------------------------------
+plot_biotype_bar <- function(data, id_col, n_col) {
+  
+  id_col <- enquo(id_col)
+  n_col <- enquo(n_col)
+  
+  data %>% 
+    ggplot(aes(x = reorder(!!id_col, dplyr::desc(!!n_col)), y = !!n_col)) +
+    geom_col() +
+    scale_y_continuous(labels = scales::percent_format(scale = 1)) +
+    coord_flip() +
+    labs(
+      y = "Porcentagem de Genes",
+      x = "Biotipo",
+    )
+  
+}
+
+dge_plot <- dge_w_biotype %>% 
+  group_by(gene_biotype) %>% 
+  summarise(biotype_n = n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
+  ungroup() %>% 
+  plot_biotype_bar(. , id_col = gene_biotype, n_col = biotype_n)
+
+dte_plot <- dte_w_biotype %>%
+  group_by(transcript_biotype) %>%
+  summarise(biotype_n = n() / length(unique(dte_w_biotype$transcript_id))* 100) %>%
+  ungroup() %>%
+  plot_biotype_bar(., id_col = transcript_biotype, n_col = biotype_n)
+
+ggsave(dge_plot, filename = "results/diff_exp/dge_biotypes.pdf")
+ggsave(dte_plot, filename = "results/diff_exp/dte_biotypes.pdf")
\ No newline at end of file

From c206ad95ea0af16eedef8cd0b18a7845f80bedec Mon Sep 17 00:00:00 2001
From: jvfe <jvfecav@gmail.com>
Date: Mon, 26 Sep 2022 16:26:17 -0300
Subject: [PATCH 02/24] Add script to compile all results from DTU

---
 .gitignore            |  1 +
 scripts/compile_DTU.R | 42 ++++++++++++++++++++++++++++++++++++++++++
 2 files changed, 43 insertions(+)
 create mode 100644 scripts/compile_DTU.R

diff --git a/.gitignore b/.gitignore
index 4ccc2ae..1aaeee8 100644
--- a/.gitignore
+++ b/.gitignore
@@ -21,3 +21,4 @@ slurm*
 run*
 data/*
 results/diff_exp/*
+results/ISA/
diff --git a/scripts/compile_DTU.R b/scripts/compile_DTU.R
new file mode 100644
index 0000000..1240f5c
--- /dev/null
+++ b/scripts/compile_DTU.R
@@ -0,0 +1,42 @@
+library(dplyr)
+library(purrr)
+library(IsoformSwitchAnalyzeR)
+
+# 1. Get all results from ISA ------
+
+files <-
+  list.files(
+    "results/ISA/",
+    pattern = "pass2",
+    recursive = T,
+    full.names = T
+  )
+isa_df <- map_dfr(files, ~ {
+  load(.x)
+  SwitchList_2$isoformFeatures
+})
+
+# 2. Filter results by conditions and save full result -----
+
+condition_1_male <- grepl("CTRL_male", isa_df$condition_1)
+condition_2_male <- grepl("MDD_male", isa_df$condition_2)
+condition_1_female <- grepl("CTRL_female", isa_df$condition_1)
+condition_2_female <- grepl("MDD_female", isa_df$condition_2)
+
+isa_df <- isa_df[(condition_1_male & condition_2_male) |
+                   (condition_1_female & condition_2_female), ]
+
+save(isa_df, file = "results/ISA/DTU_df.rda")
+
+# 3. Get dataframe with biotypes ----
+
+dtu_w_biotypes <- isa_df %>%
+  mutate(
+    gene_id = gsub("\\.\\d+", "", gene_id),
+    isoform_id = gsub("\\.\\d+", "", isoform_id)
+  ) %>%
+  filter(isoform_switch_q_value <= 0.05) %>%
+  mutate(group = gsub("_CTRL", "", condition_1)) %>%
+  dplyr::select(isoform_id, iso_biotype, group)
+
+readr::write_csv(dtu_w_biotypes, file = "results/ISA/dtu_w_biotype.csv")

From db5d36381fb22b6292c3854c7dfbcc24935faec4 Mon Sep 17 00:00:00 2001
From: jvfe <jvfecav@gmail.com>
Date: Mon, 26 Sep 2022 16:33:58 -0300
Subject: [PATCH 03/24] Add DTU results to summarise biotypes script

---
 scripts/summarise_biotypes.R | 11 +++++++++--
 1 file changed, 9 insertions(+), 2 deletions(-)

diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index 28cf2f9..fc025a1 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -46,7 +46,7 @@ readr::write_csv(dte_w_biotype, "results/diff_exp/dte_w_biotype.csv")
 
 # 2.3. Pegando biotipo dos DTU ---------------------------------------
 
-
+dtu_w_biotype <- readr::read_csv("results/ISA/dtu_w_biotype.csv")
 
 # 3. Plotando as porcentagens ---------------------------------------
 plot_biotype_bar <- function(data, id_col, n_col) {
@@ -78,5 +78,12 @@ dte_plot <- dte_w_biotype %>%
   ungroup() %>%
   plot_biotype_bar(., id_col = transcript_biotype, n_col = biotype_n)
 
+dtu_plot <- dtu_w_biotype %>%
+  group_by(iso_biotype) %>%
+  summarise(biotype_n = n() / length(unique(dtu_w_biotype$isoform_id))* 100) %>%
+  ungroup() %>%
+  plot_biotype_bar(., id_col = iso_biotype, n_col = biotype_n)
+
 ggsave(dge_plot, filename = "results/diff_exp/dge_biotypes.pdf")
-ggsave(dte_plot, filename = "results/diff_exp/dte_biotypes.pdf")
\ No newline at end of file
+ggsave(dte_plot, filename = "results/diff_exp/dte_biotypes.pdf")
+ggsave(dtu_plot, filename = "results/diff_exp/dtu_biotypes.pdf")

From c9c468ae1b1a62d181629473b936a54c7867e6de Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Sat, 15 Apr 2023 15:34:00 -0300
Subject: [PATCH 04/24] Add adjustments to scripts (libraries missing); added
 edgeR counts normalization

---
 scripts/edger_diff_gene.R | 27 ++++++++++++++++++++++-----
 scripts/impute_meta.R     |  8 ++++----
 scripts/metadata.R        |  8 ++++++--
 scripts/robust_pca.R      |  6 +++---
 scripts/tx_tx.R           |  3 +++
 5 files changed, 38 insertions(+), 14 deletions(-)

diff --git a/scripts/edger_diff_gene.R b/scripts/edger_diff_gene.R
index c7c2ea9..529a3db 100644
--- a/scripts/edger_diff_gene.R
+++ b/scripts/edger_diff_gene.R
@@ -2,6 +2,8 @@
 
 # GENE
 library(edgeR)
+library(dplyr)
+library(purrr)
 
 # Load metadata -----------------------------------------------------------
 load("results/important_variables/ann.rda")
@@ -14,9 +16,19 @@ load("results/txi/txi_gene.rda")
 
 # Differential expression -------------------------------------------------
 
-# Creating dds object with design matrix including the selected covariate ('rin' and 'ph')
-y <- DGEList(counts = txi$counts,
-             group = ann$group)
+# Creating DGElist object with design matrix including selected covariates ('rin' and 'ph').
+# See https://bioconductor.org/packages/release/bioc/vignettes/tximport/inst/doc/tximport.html#edgeR
+counts <- txi$counts
+norm_mat <- txi$length
+norm_mat <- norm_mat/exp(rowMeans(log(norm_mat)))
+norm_counts <- counts / norm_mat
+eff_library_size <- calcNormFactors(norm_counts, method = "TMM") * colSums(norm_counts)
+norm_mat <- sweep(norm_mat, 2, eff_library_size, "*")
+norm_mat <- log(norm_mat)
+
+# Creating a DGEList object for use in edgeR.
+y <- DGEList(counts, group = ann$group)
+y <- scaleOffset(y, norm_mat)
 
 # Design matrix
 design <- model.matrix(~ 0 + ph + rin + group, data = ann)
@@ -40,7 +52,7 @@ ct <- makeContrasts(
 
 # Filter low expression genes
 keep <- filterByExpr(y, group = y$samples$group)
-y <- y[keep, , keep.lib.sizes = FALSE]
+y <- y[keep,]
 
 # TMM normalization
 y <- calcNormFactors(y)
@@ -74,4 +86,9 @@ map(comp, function(c) {
 }) -> lrt_comp
 names(lrt_comp) <- comp
 
-save(df_edger_ph_rin_group_gene, lrt_comp, file = "results/diff_exp/edger_gene_rin_ph_diff.rda")
\ No newline at end of file
+if(!dir.exists("results/diff_exp/")) {
+  dir.create("results/diff_exp/")
+}
+
+save(df_edger_ph_rin_group_gene, lrt_comp, file = "results/diff_exp/edger_gene_rin_ph_diff.rda")
+
diff --git a/scripts/impute_meta.R b/scripts/impute_meta.R
index 2be92e5..955b9c2 100644
--- a/scripts/impute_meta.R
+++ b/scripts/impute_meta.R
@@ -60,10 +60,10 @@ ann_complete <- ann_complete %>%
 sum(sapply(ann_complete, function(i) sum(is.na(i)) )) == 0
 
 # Scale continuos variables
-ann_complete$age <- scale(ann_complete$age)
-ann_complete$pmi <- scale(ann_complete$pmi)
-ann_complete$rin <- scale(ann_complete$rin)
-ann_complete$ph <- scale(ann_complete$ph)
+ann_complete$age <- scale(ann_complete$age)[,1]
+ann_complete$pmi <- scale(ann_complete$pmi)[,1]
+ann_complete$rin <- scale(ann_complete$rin)[,1]
+ann_complete$ph <- scale(ann_complete$ph)[,1]
 
 # Transform categorical data
 ann_complete$gender <- as.numeric(as.factor(ann_complete$gender))
diff --git a/scripts/metadata.R b/scripts/metadata.R
index 2793e2c..3a672e1 100644
--- a/scripts/metadata.R
+++ b/scripts/metadata.R
@@ -22,11 +22,15 @@ ann <- ann %>%
   dplyr::select(sample_id, ph, rin, phenotype, gender, region, group)
 
 # Scale ph and rin
-ann$ph <- scale(ann$ph)
-ann$rin <- scale(ann$rin)
+ann$ph <- scale(ann$ph)[,1]
+ann$rin <- scale(ann$rin)[,1]
 rownames(ann) <- ann$sample_id
 ann$sample_id <- NULL
 
+# Remove samples "SRR5961961" and "SRR5961809" that appeared as outliers on robust pca analysis
+ann <- ann %>%
+  filter(!(rownames(ann) %in% c("SRR5961961", "SRR5961809")))
+
 # Save (this metadata will be used in all future models)
 save(ann, file = "results/important_variables/ann.rda")
 
diff --git a/scripts/robust_pca.R b/scripts/robust_pca.R
index 6d6edf4..4d867d8 100644
--- a/scripts/robust_pca.R
+++ b/scripts/robust_pca.R
@@ -9,11 +9,11 @@ library(DESeq2)
 
 # Load count table and annotation data
 load("results/txi/txi_gene.rda")
-load("results/important_variables/ann.rda")
+load("results/important_variables/ann_complete.rda")
 
 # DESeq2 object
 dds <- DESeqDataSetFromTximport(txi,
-                                colData = ann,
+                                colData = ann_complete,
                                 design = ~ group)
 
 v <- vst(dds, blind = F)
@@ -25,7 +25,7 @@ pdf("results/plots_paper/robust_pca.pdf")
 plot(pc1)
 dev.off()
 
-# The SRR5961961 sample is identified as divergent from others, and for this reason is excluded from 
+# The SRR5961961 and the SRR5961809 samples were considered outliers and removed from 
 # downstream analyses. 
 
 # plot(pc1$scores[,1], pc1$od)
diff --git a/scripts/tx_tx.R b/scripts/tx_tx.R
index 049e46a..01c3803 100644
--- a/scripts/tx_tx.R
+++ b/scripts/tx_tx.R
@@ -11,6 +11,9 @@ load("results/important_variables/ann.rda")
 # Read files
 files <- list.files(path = "data/kallisto/", pattern="tsv", recursive = TRUE, full.names = TRUE)
 files <- files[sapply(rownames(ann), function(x) grep(x, files))]
+
+# Samples to remove 
+
 names(files) <- rownames(ann)
 txi <- tximport(files = files, type = "kallisto", txOut = T)
 

From 1ad3ef1e15b541a9b80ffa3c158aec6152269816 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Fri, 28 Apr 2023 10:53:04 -0300
Subject: [PATCH 05/24] Major changes to DGE. Rebuilt Figures 1, 2 and 3.

---
 gwas_intersection.csv                         |   14 +
 remaining_samples.sh                          |   39 +
 renv.lock                                     |  225 +-
 results/networks/edges2                       | 2135 ---------------
 results/networks/layout.csv                   |  574 ++++
 results/networks/model_edges.txt              | 2408 +++++++++++++++++
 results/networks/model_nodes.txt              |  574 ++++
 results/networks/nodes2                       |  661 -----
 results/plots_paper/Table_1.ods               |  Bin 0 -> 55339 bytes
 results/tables/TAG.xlsx                       |  Bin 0 -> 46822 bytes
 results/tables/gwas_intersection.csv          |   14 +
 results/tables/intersect_by_type_and_gwas.csv | 1215 +++++++++
 .../tables/intersect_by_type_and_gwas.xlsx    |  Bin 0 -> 61458 bytes
 .../intersect_regions_by_sex_female.csv       |  679 +++++
 .../intersect_regions_by_sex_female.xlsx      |  Bin 0 -> 46004 bytes
 .../tables/intersect_regions_by_sex_male.csv  |  464 ++++
 .../tables/intersect_regions_by_sex_male.xlsx |  Bin 0 -> 33415 bytes
 results/tables/intersection_tables.xlsx       |  Bin 0 -> 32241 bytes
 results/tables/mdd_filtered.csv               |   52 +
 results/tables/number_of_samples.xlsx         |  Bin 0 -> 6872 bytes
 results/tx_enrich/go_terms.csv                |   22 +
 scripts/edger_diff_gene.R                     |   15 +-
 scripts/gwas_intersections.R                  |   92 +-
 scripts/network.R                             |   27 +-
 scripts/network_layout.R                      |   16 +
 scripts/organize_dge_dte_after_filtering.R    |    4 +-
 scripts/outliers_edge_ppcseq_gene.R           |    2 +
 scripts/plots.rmd                             |   43 +-
 28 files changed, 6250 insertions(+), 3025 deletions(-)
 create mode 100644 gwas_intersection.csv
 create mode 100644 remaining_samples.sh
 delete mode 100644 results/networks/edges2
 create mode 100644 results/networks/layout.csv
 create mode 100644 results/networks/model_edges.txt
 create mode 100644 results/networks/model_nodes.txt
 delete mode 100644 results/networks/nodes2
 create mode 100644 results/plots_paper/Table_1.ods
 create mode 100644 results/tables/TAG.xlsx
 create mode 100644 results/tables/gwas_intersection.csv
 create mode 100644 results/tables/intersect_by_type_and_gwas.csv
 create mode 100644 results/tables/intersect_by_type_and_gwas.xlsx
 create mode 100644 results/tables/intersect_regions_by_sex_female.csv
 create mode 100644 results/tables/intersect_regions_by_sex_female.xlsx
 create mode 100644 results/tables/intersect_regions_by_sex_male.csv
 create mode 100644 results/tables/intersect_regions_by_sex_male.xlsx
 create mode 100644 results/tables/intersection_tables.xlsx
 create mode 100644 results/tables/mdd_filtered.csv
 create mode 100644 results/tables/number_of_samples.xlsx
 create mode 100644 results/tx_enrich/go_terms.csv
 create mode 100644 scripts/network_layout.R

diff --git a/gwas_intersection.csv b/gwas_intersection.csv
new file mode 100644
index 0000000..8359231
--- /dev/null
+++ b/gwas_intersection.csv
@@ -0,0 +1,14 @@
+association_id,variant_id,risk_allele,risk_frequency,genome_wide,pvalue,pvalue_description,range,beta_number,beta_direction,chromosome_name,chromosome_position,functional_class,ensembl_gene_name,hgnc_symbol,group,type
+41136253,rs58621819,T,0.2097,FALSE,2e-10,NA,[1.01-1.02],NA,NA,11,65547359,intron_variant,ENSG00000168056,LTBP3,OFC_female,DGE
+41136409,rs12923444,C,0.4375,FALSE,2e-24,NA,[1.02-1.03],NA,NA,16,21628389,intron_variant,ENSG00000197006,METTL9,OFC_female,DGE
+41135995,rs10789214,T,0.5661,FALSE,4e-10,NA,[1.009-1.018],NA,NA,1,66681134,intron_variant,ENSG00000118473,SGIP1,OFC_female,DTE
+41136026,rs17641524,C,0.7909,FALSE,8e-20,NA,[1.02-1.03],NA,NA,1,197735587,splice_region_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
+41136085,rs45510091,A,0.9472,FALSE,8e-21,NA,[1.037-1.057],NA,NA,4,122265238,intron_variant,ENSG00000138688,BLTP1,Cg25_male,DGE
+30547745,rs10127497,T,0.1382,FALSE,1e-08,NA,[0.0064-0.013],0.0097,increase,1,66584461,intron_variant,ENSG00000118473,SGIP1,OFC_female,DTE
+30547749,rs6679379,T,0.2875,FALSE,3e-08,NA,[0.0047-0.0097],0.0072,increase,1,66733473,non_coding_transcript_exon_variant,ENSG00000118473,SGIP1,OFC_female,DTE
+30547797,rs12118513,A,0.2148,FALSE,1e-07,NA,[0.0049-0.0103],0.0076,decrease,1,197547956,intron_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
+30547801,rs17641524,T,0.2086,FALSE,2e-07,NA,[0.0048-0.0102],0.0075,decrease,1,197735587,splice_region_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
+30547485,rs10929355,G,0.4558,FALSE,6e-09,NA,[0.005-0.01],0.0075,decrease,2,15258840,intron_variant,ENSG00000151779,NBAS,OFC_female,DGE
+64732910,rs2894699,T,0.4305,FALSE,4e-09,NA,[0.017-0.033],0.024859993,decrease,7,114419101,intron_variant,ENSG00000128573,FOXP2,Sub_male,DGE
+64733014,rs7146581,T,0.2246,FALSE,2e-08,NA,[0.018-0.037],0.027423386,increase,14,102834735,intron_variant,ENSG00000131323,TRAF3,Nac_female,DTE
+64733043,rs2369818,T,0.4386,FALSE,3e-08,NA,[0.015-0.031],0.023054866,increase,16,21602688,intron_variant,ENSG00000197006,METTL9,OFC_female,DGE
diff --git a/remaining_samples.sh b/remaining_samples.sh
new file mode 100644
index 0000000..a65496c
--- /dev/null
+++ b/remaining_samples.sh
@@ -0,0 +1,39 @@
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961862/SRR5961862_2.fastq.gz -o SRR5961862_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961863/SRR5961863_2.fastq.gz -o SRR5961863_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961864/SRR5961864_1.fastq.gz -o SRR5961864_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961864/SRR5961864_2.fastq.gz -o SRR5961864_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/008/SRR5961938/SRR5961938_2.fastq.gz -o SRR5961938_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961937/SRR5961937_1.fastq.gz -o SRR5961937_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961937/SRR5961937_2.fastq.gz -o SRR5961937_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961942/SRR5961942_1.fastq.gz -o SRR5961942_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961942/SRR5961942_2.fastq.gz -o SRR5961942_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961940/SRR5961940_1.fastq.gz -o SRR5961940_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961940/SRR5961940_2.fastq.gz -o SRR5961940_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961943/SRR5961943_1.fastq.gz -o SRR5961943_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961943/SRR5961943_2.fastq.gz -o SRR5961943_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961944/SRR5961944_1.fastq.gz -o SRR5961944_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961944/SRR5961944_2.fastq.gz -o SRR5961944_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961946/SRR5961946_1.fastq.gz -o SRR5961946_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961946/SRR5961946_2.fastq.gz -o SRR5961946_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961945/SRR5961945_1.fastq.gz -o SRR5961945_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961945/SRR5961945_2.fastq.gz -o SRR5961945_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961947/SRR5961947_1.fastq.gz -o SRR5961947_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961947/SRR5961947_2.fastq.gz -o SRR5961947_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/008/SRR5961948/SRR5961948_1.fastq.gz -o SRR5961948_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/008/SRR5961948/SRR5961948_2.fastq.gz -o SRR5961948_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/009/SRR5961949/SRR5961949_1.fastq.gz -o SRR5961949_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/009/SRR5961949/SRR5961949_2.fastq.gz -o SRR5961949_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961950/SRR5961950_1.fastq.gz -o SRR5961950_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961950/SRR5961950_2.fastq.gz -o SRR5961950_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/001/SRR5961951/SRR5961951_1.fastq.gz -o SRR5961951_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/001/SRR5961951/SRR5961951_2.fastq.gz -o SRR5961951_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961952/SRR5961952_1.fastq.gz -o SRR5961952_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961952/SRR5961952_2.fastq.gz -o SRR5961952_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961953/SRR5961953_2.fastq.gz -o SRR5961953_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961954/SRR5961954_1.fastq.gz -o SRR5961954_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961954/SRR5961954_2.fastq.gz -o SRR5961954_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961955/SRR5961955_1.fastq.gz -o SRR5961955_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961955/SRR5961955_2.fastq.gz -o SRR5961955_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961956/SRR5961956_1.fastq.gz -o SRR5961956_1.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961956/SRR5961956_2.fastq.gz -o SRR5961956_2.fastq.gz
+curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961957/SRR5961957_1.fastq.gz -o SRR5961957_1.fastq.gz
diff --git a/renv.lock b/renv.lock
index ec24f2c..5e7a305 100644
--- a/renv.lock
+++ b/renv.lock
@@ -905,6 +905,21 @@
         "S4Vectors"
       ]
     },
+    "TreeAndLeaf": {
+      "Package": "TreeAndLeaf",
+      "Version": "1.6.1",
+      "Source": "Bioconductor",
+      "git_url": "https://git.bioconductor.org/packages/TreeAndLeaf",
+      "git_branch": "RELEASE_3_14",
+      "git_last_commit": "171d519",
+      "git_last_commit_date": "2021-10-27",
+      "Hash": "b8f10ab9082a4c3cbcc136006706ef4e",
+      "Requirements": [
+        "RedeR",
+        "ape",
+        "igraph"
+      ]
+    },
     "UpSetR": {
       "Package": "UpSetR",
       "Version": "1.4.0",
@@ -1181,14 +1196,6 @@
       "Hash": "0baa960e3b49c6176a4f42addcbacc59",
       "Requirements": []
     },
-    "brio": {
-      "Package": "brio",
-      "Version": "1.1.3",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "976cf154dfb043c012d87cddd8bca363",
-      "Requirements": []
-    },
     "broom": {
       "Package": "broom",
       "Version": "0.7.11",
@@ -1335,13 +1342,11 @@
     },
     "cli": {
       "Package": "cli",
-      "Version": "3.1.0",
+      "Version": "3.6.1",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "66a3834e54593c89d8beefb312347e58",
-      "Requirements": [
-        "glue"
-      ]
+      "Hash": "89e6d8219950eac806ae0c489052048a",
+      "Requirements": []
     },
     "clipr": {
       "Package": "clipr",
@@ -1410,14 +1415,6 @@
       "Hash": "0f22be39ec1d141fd03683c06f3a6e67",
       "Requirements": []
     },
-    "concatenate": {
-      "Package": "concatenate",
-      "Version": "1.0.0",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "94b165d30bf16386c2f096409d502463",
-      "Requirements": []
-    },
     "conquer": {
       "Package": "conquer",
       "Version": "1.2.1",
@@ -1516,13 +1513,13 @@
     },
     "desc": {
       "Package": "desc",
-      "Version": "1.4.0",
+      "Version": "1.4.2",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "28763d08fadd0b733e3cee9dab4e12fe",
+      "Hash": "6b9602c7ebbe87101a9c8edb6e8b6d21",
       "Requirements": [
         "R6",
-        "crayon",
+        "cli",
         "rprojroot"
       ]
     },
@@ -1534,16 +1531,6 @@
       "Hash": "fe1a3788cf243db3eca07ae661860793",
       "Requirements": []
     },
-    "diffobj": {
-      "Package": "diffobj",
-      "Version": "0.3.5",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "bcaa8b95f8d7d01a5dedfd959ce88ab8",
-      "Requirements": [
-        "crayon"
-      ]
-    },
     "digest": {
       "Package": "digest",
       "Version": "0.6.29",
@@ -2156,12 +2143,13 @@
       "Package": "ggtree",
       "Version": "3.2.1",
       "Source": "Bioconductor",
+      "RemoteType": "bioconductor",
       "Remotes": "GuangchuangYu/treeio",
       "git_url": "https://git.bioconductor.org/packages/ggtree",
       "git_branch": "RELEASE_3_14",
       "git_last_commit": "d3747e6",
       "git_last_commit_date": "2021-11-14",
-      "Hash": "f156c85173024c88e2fdfd63ccca3fd7",
+      "Hash": "5711c057a04e53ed1c70909939dd9ad9",
       "Requirements": [
         "ape",
         "aplot",
@@ -2319,33 +2307,6 @@
       "Hash": "2ace6c4a06297d0b364e0444384a2b82",
       "Requirements": []
     },
-    "gwasrapidd": {
-      "Package": "gwasrapidd",
-      "Version": "0.99.12",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "56be6fbe33e1892fea54591d36881510",
-      "Requirements": [
-        "assertthat",
-        "concatenate",
-        "dplyr",
-        "glue",
-        "httr",
-        "jsonlite",
-        "lubridate",
-        "magrittr",
-        "pingr",
-        "plyr",
-        "progress",
-        "purrr",
-        "rlang",
-        "stringr",
-        "testthat",
-        "tibble",
-        "tidyr",
-        "urltools"
-      ]
-    },
     "haven": {
       "Package": "haven",
       "Version": "2.4.3",
@@ -2901,10 +2862,10 @@
     },
     "openssl": {
       "Package": "openssl",
-      "Version": "1.4.6",
+      "Version": "2.0.6",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "69fdf291af288f32fd4cd93315084ea8",
+      "Hash": "0f7cd2962e3044bb940cca4f4b5cecbe",
       "Requirements": [
         "askpass"
       ]
@@ -3017,16 +2978,6 @@
         "vctrs"
       ]
     },
-    "pingr": {
-      "Package": "pingr",
-      "Version": "2.0.1",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "e293e79be42ffd336d938937fd3017fb",
-      "Requirements": [
-        "processx"
-      ]
-    },
     "pkgbuild": {
       "Package": "pkgbuild",
       "Version": "1.3.1",
@@ -3052,22 +3003,6 @@
       "Hash": "01f28d4278f15c76cddbea05899c5d6f",
       "Requirements": []
     },
-    "pkgload": {
-      "Package": "pkgload",
-      "Version": "1.2.4",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "7533cd805940821bf23eaf3c8d4c1735",
-      "Requirements": [
-        "cli",
-        "crayon",
-        "desc",
-        "rlang",
-        "rprojroot",
-        "rstudioapi",
-        "withr"
-      ]
-    },
     "plogr": {
       "Package": "plogr",
       "Version": "0.2.0",
@@ -3152,14 +3087,6 @@
         "tidyr"
       ]
     },
-    "praise": {
-      "Package": "praise",
-      "Version": "1.0.0",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "a555924add98c99d2f411e37e7d25e9f",
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-    },
     "prettyunits": {
       "Package": "prettyunits",
       "Version": "1.1.1",
@@ -3291,6 +3218,14 @@
         "reshape2"
       ]
     },
+    "rJava": {
+      "Package": "rJava",
+      "Version": "1.0-6",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "0415819f6baa75d86d52483f7292b623",
+      "Requirements": []
+    },
     "ranger": {
       "Package": "ranger",
       "Version": "0.13.1",
@@ -3452,10 +3387,10 @@
     },
     "rlang": {
       "Package": "rlang",
-      "Version": "0.4.12",
+      "Version": "1.1.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "0879f5388fe6e4d56d7ef0b7ccb031e5",
+      "Hash": "dc079ccd156cde8647360f473c1fa718",
       "Requirements": []
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     "rmarkdown": {
@@ -3828,34 +3763,6 @@
       "Hash": "fd792ceac77f96b647fa8d6e1788969a",
       "Requirements": []
     },
-    "testthat": {
-      "Package": "testthat",
-      "Version": "3.1.1",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "2a5c5646456762131ce40272964599d3",
-      "Requirements": [
-        "R6",
-        "brio",
-        "callr",
-        "cli",
-        "crayon",
-        "desc",
-        "digest",
-        "ellipsis",
-        "evaluate",
-        "jsonlite",
-        "lifecycle",
-        "magrittr",
-        "pkgload",
-        "praise",
-        "processx",
-        "ps",
-        "rlang",
-        "waldo",
-        "withr"
-      ]
-    },
     "tibble": {
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@@ -4040,16 +3947,6 @@
         "tidytree"
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-      "Hash": "847a9d113b78baca4a9a8639609ea228",
-      "Requirements": [
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     "tweenr": {
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@@ -4111,17 +4008,6 @@
         "cpp11"
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-    "urltools": {
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-      "Version": "1.7.3",
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-      "Repository": "CRAN",
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-        "triebeard"
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@@ -4205,28 +4091,12 @@
         "withr"
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-      "Hash": "ad8cfff5694ac5b3c354f8f2044bd976",
-      "Requirements": [
-        "cli",
-        "diffobj",
-        "fansi",
-        "glue",
-        "rematch2",
-        "rlang",
-        "tibble"
-      ]
-    },
     "withr": {
       "Package": "withr",
-      "Version": "2.4.3",
+      "Version": "2.5.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "a376b424c4817cda4920bbbeb3364e85",
+      "Hash": "c0e49a9760983e81e55cdd9be92e7182",
       "Requirements": []
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     "xfun": {
@@ -4237,6 +4107,27 @@
       "Hash": "e2e5fb1a74fbb68b27d6efc5372635dc",
       "Requirements": []
     },
+    "xlsx": {
+      "Package": "xlsx",
+      "Version": "0.6.5",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "d24d579f59a3b6da1e1cf4660425443e",
+      "Requirements": [
+        "rJava",
+        "xlsxjars"
+      ]
+    },
+    "xlsxjars": {
+      "Package": "xlsxjars",
+      "Version": "0.6.1",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "4c4b3bc29a916f33f1298dd951133351",
+      "Requirements": [
+        "rJava"
+      ]
+    },
     "xml2": {
       "Package": "xml2",
       "Version": "1.3.3",
diff --git a/results/networks/edges2 b/results/networks/edges2
deleted file mode 100644
index e167bbd..0000000
--- a/results/networks/edges2
+++ /dev/null
@@ -1,2135 +0,0 @@
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diff --git a/results/networks/layout.csv b/results/networks/layout.csv
new file mode 100644
index 0000000..6fd43a8
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diff --git a/results/networks/model_edges.txt b/results/networks/model_edges.txt
new file mode 100644
index 0000000..493da78
--- /dev/null
+++ b/results/networks/model_edges.txt
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diff --git a/results/networks/model_nodes.txt b/results/networks/model_nodes.txt
new file mode 100644
index 0000000..1c31085
--- /dev/null
+++ b/results/networks/model_nodes.txt
@@ -0,0 +1,574 @@
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+1	VPS53	ELLIPSE	20.0	#ffcccc	426.1	192.06	0.0
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+3	STX5	ELLIPSE	20.0	#ffcccc	393.29	22.8	0.0
+4	SNAP47	ELLIPSE	20.0	#ffcccc	614.44	-72.34	0.0
+5	PKP2	ELLIPSE	20.0	#ffcccc	159.97	1087.33	0.0
+6	KRT18	ELLIPSE	20.0	#ffcccc	245.34	1330.12	0.0
+7	CTNNB1	ELLIPSE	20.0	#ffcccc	-50.61	641.73	0.0
+8	MRPS35	ELLIPSE	20.0	#ffcccc	-574.2	88.33	0.0
+9	C18orf32	ELLIPSE	20.0	#ffcccc	-374.66	156.25	0.0
+10	RPL17-C18orf32	ELLIPSE	20.0	#ffcccc	-356.15	151.35	0.0
+11	HSPBP1	ELLIPSE	20.0	#ffcccc	-384.98	32.64	0.0
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+567	ATP2B1	ELLIPSE	20.0	#ffcccc	37.45	707.27	0.0
+568	ZNF746	ELLIPSE	20.0	#ffcccc	-189.29	-356.66	0.0
+569	HSPB6	ELLIPSE	20.0	#ffcccc	381.07	707.71	0.0
+570	CALU	ELLIPSE	20.0	#ffcccc	1405.8	-594.06	0.0
+571	SARS2	ELLIPSE	20.0	#ffcccc	1470.02	-669.57	0.0
+572	CIC	ELLIPSE	20.0	#ffcccc	-965.79	907.27	0.0
diff --git a/results/networks/nodes2 b/results/networks/nodes2
deleted file mode 100644
index 2657779..0000000
--- a/results/networks/nodes2
+++ /dev/null
@@ -1,661 +0,0 @@
-node_id	alias	shape	size	color	x	y	weight
-0	ARF5	ELLIPSE	20.0	#ffcccc	841.61	287.3	0.0
-1	UNK	ELLIPSE	20.0	#ffcccc	696.11	-13.41	0.0
-2	AP1B1	ELLIPSE	20.0	#ffcccc	883.35	495.1	0.0
-3	SYNGAP1	ELLIPSE	20.0	#ffcccc	1111.97	410.88	0.0
-4	ANK2	ELLIPSE	20.0	#ffcccc	746.61	447.89	0.0
-5	BET1	ELLIPSE	20.0	#ffcccc	906.74	364.24	0.0
-6	COPZ1	ELLIPSE	20.0	#ffcccc	718.75	337.52	0.0
-7	ARCN1	ELLIPSE	20.0	#ffcccc	597.73	320.92	0.0
-8	COPB2	ELLIPSE	20.0	#ffcccc	793.91	356.14	0.0
-9	ARFGAP3	ELLIPSE	20.0	#ffcccc	867.64	401.51	0.0
-10	ARFGAP1	ELLIPSE	20.0	#ffcccc	844.23	494.3	0.0
-11	INMT	ELLIPSE	20.0	#ffcccc	2085.4	-322.65	0.0
-12	IDO2	ELLIPSE	20.0	#ffcccc	2152.15	-289.13	0.0
-13	ERCC1	ELLIPSE	20.0	#ffcccc	138.61	860.95	0.0
-14	POLR2K	ELLIPSE	20.0	#ffcccc	-61.26	748.31	0.0
-15	UBB	ELLIPSE	20.0	#ffcccc	588.13	578.51	0.0
-16	POLR2F	ELLIPSE	20.0	#ffcccc	-87.56	675.71	0.0
-17	CHD1L	ELLIPSE	20.0	#ffcccc	171.64	381.95	0.0
-18	HMGN1	ELLIPSE	20.0	#ffcccc	28.26	878.23	0.0
-19	GTF2H3	ELLIPSE	20.0	#ffcccc	46.62	685.12	0.0
-20	FANCF	ELLIPSE	20.0	#ffcccc	189.93	1014.11	0.0
-21	PMS1	ELLIPSE	20.0	#ffcccc	62.3	769.35	0.0
-22	FANCC	ELLIPSE	20.0	#ffcccc	257.72	1031.73	0.0
-23	DDB2	ELLIPSE	20.0	#ffcccc	161.05	694.89	0.0
-24	RHNO1	ELLIPSE	20.0	#ffcccc	311.68	993.67	0.0
-25	RAD1	ELLIPSE	20.0	#ffcccc	255.14	930.89	0.0
-26	SLX1A	ELLIPSE	20.0	#ffcccc	-29.21	1092.19	0.0
-27	CETN2	ELLIPSE	20.0	#ffcccc	156.78	623.39	0.0
-28	USP45	ELLIPSE	20.0	#ffcccc	212.98	1058.68	0.0
-29	TARBP1	ELLIPSE	20.0	#ffcccc	-443.39	-8.51	0.0
-30	NOL6	ELLIPSE	20.0	#ffcccc	-209.48	117.9	0.0
-31	RTN4R	ELLIPSE	20.0	#ffcccc	1589.89	1819.99	0.0
-32	RTN4	ELLIPSE	20.0	#ffcccc	1668.11	1821.99	0.0
-33	RCN1	ELLIPSE	20.0	#ffcccc	1462.1	758.32	0.0
-34	MYL6	ELLIPSE	20.0	#ffcccc	1263.46	692.14	0.0
-35	PKP2	ELLIPSE	20.0	#ffcccc	2823.51	-460.09	0.0
-36	KRT18	ELLIPSE	20.0	#ffcccc	2789.84	-390.77	0.0
-37	NDUFB4	ELLIPSE	20.0	#ffcccc	-198.57	-363.51	0.0
-38	COX6C	ELLIPSE	20.0	#ffcccc	-220.11	-211.94	0.0
-39	ATP5F1E	ELLIPSE	20.0	#ffcccc	-19.83	-283.42	0.0
-40	COX7C	ELLIPSE	20.0	#ffcccc	-54.13	-151.49	0.0
-41	ATP5MF	ELLIPSE	20.0	#ffcccc	-36.9	-368.58	0.0
-42	TIMMDC1	ELLIPSE	20.0	#ffcccc	-246.79	-464.18	0.0
-43	UQCR11	ELLIPSE	20.0	#ffcccc	-172.92	-281.26	0.0
-44	UQCRQ	ELLIPSE	20.0	#ffcccc	-122.89	-167.91	0.0
-45	NDUFB10	ELLIPSE	20.0	#ffcccc	-81.04	-246.71	0.0
-46	SLC22A4	ELLIPSE	20.0	#ffcccc	439.38	1626.13	0.0
-47	PDZK1	ELLIPSE	20.0	#ffcccc	449.48	1481.8	0.0
-48	VCL	ELLIPSE	20.0	#ffcccc	990.04	661.6	0.0
-49	ARRB2	ELLIPSE	20.0	#ffcccc	940.15	830.98	0.0
-50	SCAF4	ELLIPSE	20.0	#ffcccc	696.46	1132.1	0.0
-51	DAG1	ELLIPSE	20.0	#ffcccc	1222.33	657.83	0.0
-52	PICALM	ELLIPSE	20.0	#ffcccc	757.58	531.81	0.0
-53	MYL12A	ELLIPSE	20.0	#ffcccc	1163.8	666.73	0.0
-54	MANF	ELLIPSE	20.0	#ffcccc	713.2	407.35	0.0
-55	ACTG1	ELLIPSE	20.0	#ffcccc	1061.39	550.63	0.0
-56	CTNND1	ELLIPSE	20.0	#ffcccc	1256.47	626.39	0.0
-57	ZYX	ELLIPSE	20.0	#ffcccc	1060.68	412.73	0.0
-58	MIF	ELLIPSE	20.0	#ffcccc	184.74	-80.38	0.0
-59	RPS28	ELLIPSE	20.0	#ffcccc	347.42	140.89	0.0
-60	NME2	ELLIPSE	20.0	#ffcccc	321.59	8.65	0.0
-61	PARK7	ELLIPSE	20.0	#ffcccc	212.3	149.2	0.0
-62	HSCB	ELLIPSE	20.0	#ffcccc	-60.44	-75.36	0.0
-63	SDHB	ELLIPSE	20.0	#ffcccc	28.9	-193.7	0.0
-64	ISCA1	ELLIPSE	20.0	#ffcccc	-164.65	-110.94	0.0
-65	HSPA9	ELLIPSE	20.0	#ffcccc	167.38	166.28	0.0
-66	ST13	ELLIPSE	20.0	#ffcccc	597.2	370.91	0.0
-67	PDIA4	ELLIPSE	20.0	#ffcccc	801.92	518.82	0.0
-68	TFG	ELLIPSE	20.0	#ffcccc	893.75	312.98	0.0
-69	HSPA8	ELLIPSE	20.0	#ffcccc	275.73	461.19	0.0
-70	PNN	ELLIPSE	20.0	#ffcccc	-366.98	613.33	0.0
-71	RSRC2	ELLIPSE	20.0	#ffcccc	-605.25	700.17	0.0
-72	SMG6	ELLIPSE	20.0	#ffcccc	-69.88	538.55	0.0
-73	HNRNPA2B1	ELLIPSE	20.0	#ffcccc	1.97	421.11	0.0
-74	U2AF2	ELLIPSE	20.0	#ffcccc	-363.02	509.85	0.0
-75	HNRNPH3	ELLIPSE	20.0	#ffcccc	-334.97	435.87	0.0
-76	ARGLU1	ELLIPSE	20.0	#ffcccc	-461.16	556.22	0.0
-77	CASC3	ELLIPSE	20.0	#ffcccc	-248.57	667.24	0.0
-78	PNISR	ELLIPSE	20.0	#ffcccc	-572.7	572.77	0.0
-79	RNPS1	ELLIPSE	20.0	#ffcccc	-141.45	663.9	0.0
-80	ACOT8	ELLIPSE	20.0	#ffcccc	-475.26	1031.22	0.0
-81	PEX7	ELLIPSE	20.0	#ffcccc	-0.36	682.64	0.0
-82	PAOX	ELLIPSE	20.0	#ffcccc	-581.65	1168.91	0.0
-83	SCP2	ELLIPSE	20.0	#ffcccc	-672.82	1158.48	0.0
-84	SLC27A2	ELLIPSE	20.0	#ffcccc	-631.26	1084.53	0.0
-85	GNPAT	ELLIPSE	20.0	#ffcccc	-575.39	1110.65	0.0
-86	RAC1	ELLIPSE	20.0	#ffcccc	1283.67	472.38	0.0
-87	PAK3	ELLIPSE	20.0	#ffcccc	1218.51	791.08	0.0
-88	PSMD10	ELLIPSE	20.0	#ffcccc	356.61	189.06	0.0
-89	UBE3A	ELLIPSE	20.0	#ffcccc	530.92	197.56	0.0
-90	SRP9	ELLIPSE	20.0	#ffcccc	65.29	278.32	0.0
-91	PSMF1	ELLIPSE	20.0	#ffcccc	509.36	134.56	0.0
-92	PSME3	ELLIPSE	20.0	#ffcccc	259.31	309.38	0.0
-93	PSMB10	ELLIPSE	20.0	#ffcccc	477.28	190.96	0.0
-94	OAZ1	ELLIPSE	20.0	#ffcccc	431.04	63.75	0.0
-95	OAZ3	ELLIPSE	20.0	#ffcccc	369.99	73.0	0.0
-96	GLI1	ELLIPSE	20.0	#ffcccc	532.16	374.26	0.0
-97	PSMB5	ELLIPSE	20.0	#ffcccc	417.29	193.41	0.0
-98	SEM1	ELLIPSE	20.0	#ffcccc	451.99	123.82	0.0
-99	STAG2	ELLIPSE	20.0	#ffcccc	277.93	872.88	0.0
-100	WDR44	ELLIPSE	20.0	#ffcccc	255.7	190.79	0.0
-101	JUND	ELLIPSE	20.0	#ffcccc	431.21	979.55	0.0
-102	HIST1H2AC	ELLIPSE	20.0	#ffcccc	385.46	805.05	0.0
-103	TERF2	ELLIPSE	20.0	#ffcccc	227.69	1125.9	0.0
-104	CCNB1	ELLIPSE	20.0	#ffcccc	519.34	922.16	0.0
-105	SMC5	ELLIPSE	20.0	#ffcccc	149.36	1117.63	0.0
-106	SMC1A	ELLIPSE	20.0	#ffcccc	195.14	876.34	0.0
-107	TIMP1	ELLIPSE	20.0	#ffcccc	2913.78	241.28	0.0
-108	CD63	ELLIPSE	20.0	#ffcccc	2947.22	318.55	0.0
-109	CORO1A	ELLIPSE	20.0	#ffcccc	1416.58	221.31	0.0
-110	AKTIP	ELLIPSE	20.0	#ffcccc	1450.14	450.03	0.0
-111	CD37	ELLIPSE	20.0	#ffcccc	1571.88	112.15	0.0
-112	POC1A	ELLIPSE	20.0	#ffcccc	986.91	234.0	0.0
-113	DOCK2	ELLIPSE	20.0	#ffcccc	1585.86	232.12	0.0
-114	NME3	ELLIPSE	20.0	#ffcccc	438.91	-230.18	0.0
-115	BBS2	ELLIPSE	20.0	#ffcccc	403.92	-25.03	0.0
-116	NME7	ELLIPSE	20.0	#ffcccc	445.26	-303.64	0.0
-117	NUDT2	ELLIPSE	20.0	#ffcccc	375.33	-283.2	0.0
-118	GUK1	ELLIPSE	20.0	#ffcccc	543.88	-368.29	0.0
-119	ARHGDIG	ELLIPSE	20.0	#ffcccc	1581.54	421.34	0.0
-120	STUB1	ELLIPSE	20.0	#ffcccc	573.18	109.97	0.0
-121	JOSD2	ELLIPSE	20.0	#ffcccc	733.27	31.24	0.0
-122	CLPP	ELLIPSE	20.0	#ffcccc	322.16	-131.3	0.0
-123	CCT8	ELLIPSE	20.0	#ffcccc	326.04	298.39	0.0
-124	CCT3	ELLIPSE	20.0	#ffcccc	295.85	256.82	0.0
-125	TWIST1	ELLIPSE	20.0	#ffcccc	623.34	504.52	0.0
-126	KCNH2	ELLIPSE	20.0	#ffcccc	507.31	258.13	0.0
-127	UBE2E1	ELLIPSE	20.0	#ffcccc	547.14	284.82	0.0
-128	UBE2E2	ELLIPSE	20.0	#ffcccc	681.2	63.04	0.0
-129	B4GAT1	ELLIPSE	20.0	#ffcccc	675.1	-114.52	0.0
-130	PEDS1-UBE2V1	ELLIPSE	20.0	#ffcccc	868.19	-157.66	0.0
-131	RIPK1	ELLIPSE	20.0	#ffcccc	930.37	252.74	0.0
-132	UBE2V1	ELLIPSE	20.0	#ffcccc	775.94	190.22	0.0
-133	MGA	ELLIPSE	20.0	#ffcccc	242.85	-311.82	0.0
-134	ZMYND8	ELLIPSE	20.0	#ffcccc	244.01	-543.43	0.0
-135	BOLA2-SMG1P6	ELLIPSE	20.0	#ffcccc	500.99	-22.68	0.0
-136	PELP1	ELLIPSE	20.0	#ffcccc	-61.3	-206.45	0.0
-137	AQP9	ELLIPSE	20.0	#ffcccc	2438.54	1674.86	0.0
-138	AQP7	ELLIPSE	20.0	#ffcccc	2363.34	1677.46	0.0
-139	EIF3E	ELLIPSE	20.0	#ffcccc	59.65	339.11	0.0
-140	MPND	ELLIPSE	20.0	#ffcccc	380.1	285.66	0.0
-141	MYSM1	ELLIPSE	20.0	#ffcccc	482.44	319.38	0.0
-142	RPL34	ELLIPSE	20.0	#ffcccc	188.32	113.77	0.0
-143	RPL13A	ELLIPSE	20.0	#ffcccc	26.69	-23.87	0.0
-144	GTPBP4	ELLIPSE	20.0	#ffcccc	-183.81	345.13	0.0
-145	RPL31	ELLIPSE	20.0	#ffcccc	248.8	99.18	0.0
-146	RPL26	ELLIPSE	20.0	#ffcccc	230.15	-8.52	0.0
-147	RPL3L	ELLIPSE	20.0	#ffcccc	138.47	246.63	0.0
-148	RPL7A	ELLIPSE	20.0	#ffcccc	115.25	-2.49	0.0
-149	RPL27	ELLIPSE	20.0	#ffcccc	-43.78	15.66	0.0
-150	RPL24	ELLIPSE	20.0	#ffcccc	-99.7	61.47	0.0
-151	RPL7	ELLIPSE	20.0	#ffcccc	76.94	80.81	0.0
-152	RPL18	ELLIPSE	20.0	#ffcccc	122.91	479.94	0.0
-153	EIF1	ELLIPSE	20.0	#ffcccc	76.91	169.82	0.0
-154	RPS20	ELLIPSE	20.0	#ffcccc	-222.97	247.33	0.0
-155	RPS10	ELLIPSE	20.0	#ffcccc	-124.58	210.16	0.0
-156	RPS19	ELLIPSE	20.0	#ffcccc	222.26	456.75	0.0
-157	RACK1	ELLIPSE	20.0	#ffcccc	473.17	369.09	0.0
-158	RPS3	ELLIPSE	20.0	#ffcccc	38.0	577.82	0.0
-159	EIF4G1	ELLIPSE	20.0	#ffcccc	77.64	441.43	0.0
-160	EIF3L	ELLIPSE	20.0	#ffcccc	13.09	264.17	0.0
-161	EIF3CL	ELLIPSE	20.0	#ffcccc	127.6	206.22	0.0
-162	EIF3C	ELLIPSE	20.0	#ffcccc	176.52	260.84	0.0
-163	GSR	ELLIPSE	20.0	#ffcccc	457.28	-647.78	0.0
-164	PDHB	ELLIPSE	20.0	#ffcccc	208.51	-267.82	0.0
-165	GSTP1	ELLIPSE	20.0	#ffcccc	601.85	-819.73	0.0
-166	GGT5	ELLIPSE	20.0	#ffcccc	596.84	-755.2	0.0
-167	SNAPC2	ELLIPSE	20.0	#ffcccc	-190.69	959.25	0.0
-168	GTF2E2	ELLIPSE	20.0	#ffcccc	-148.25	885.22	0.0
-169	ZNF143	ELLIPSE	20.0	#ffcccc	-237.8	928.15	0.0
-170	APLP1	ELLIPSE	20.0	#ffcccc	1536.39	1078.01	0.0
-171	KIF5A	ELLIPSE	20.0	#ffcccc	1293.14	897.8	0.0
-172	APBB3	ELLIPSE	20.0	#ffcccc	1663.38	1170.77	0.0
-173	RABAC1	ELLIPSE	20.0	#ffcccc	1746.17	1822.48	0.0
-174	GCDH	ELLIPSE	20.0	#ffcccc	85.37	-755.26	0.0
-175	ETFDH	ELLIPSE	20.0	#ffcccc	130.15	-598.06	0.0
-176	COMP	ELLIPSE	20.0	#ffcccc	1759.79	598.65	0.0
-177	ITGA9	ELLIPSE	20.0	#ffcccc	1565.99	560.48	0.0
-178	SNAP47	ELLIPSE	20.0	#ffcccc	1058.12	344.06	0.0
-179	GRIA1	ELLIPSE	20.0	#ffcccc	1018.9	583.83	0.0
-180	SEC22A	ELLIPSE	20.0	#ffcccc	908.62	437.16	0.0
-181	STX5	ELLIPSE	20.0	#ffcccc	1005.26	418.21	0.0
-182	CHN2	ELLIPSE	20.0	#ffcccc	1301.16	299.39	0.0
-183	RBM28	ELLIPSE	20.0	#ffcccc	-321.69	189.26	0.0
-184	IFI16	ELLIPSE	20.0	#ffcccc	-283.37	31.15	0.0
-185	FTSJ1	ELLIPSE	20.0	#ffcccc	-396.54	117.48	0.0
-186	C7orf50	ELLIPSE	20.0	#ffcccc	-347.32	323.95	0.0
-187	DHX32	ELLIPSE	20.0	#ffcccc	-392.58	327.97	0.0
-188	GPATCH4	ELLIPSE	20.0	#ffcccc	-90.78	430.57	0.0
-189	GNL1	ELLIPSE	20.0	#ffcccc	-219.58	170.35	0.0
-190	NVL	ELLIPSE	20.0	#ffcccc	-330.52	262.57	0.0
-191	SNU13	ELLIPSE	20.0	#ffcccc	-206.26	460.06	0.0
-192	BRIX1	ELLIPSE	20.0	#ffcccc	-165.28	232.55	0.0
-193	DDX47	ELLIPSE	20.0	#ffcccc	-83.94	305.04	0.0
-194	FIS1	ELLIPSE	20.0	#ffcccc	301.03	-379.2	0.0
-195	MAF1	ELLIPSE	20.0	#ffcccc	264.02	-159.01	0.0
-196	SFXN3	ELLIPSE	20.0	#ffcccc	-369.62	-313.93	0.0
-197	SUPT4H1	ELLIPSE	20.0	#ffcccc	-165.53	555.5	0.0
-198	ELOC	ELLIPSE	20.0	#ffcccc	14.7	467.18	0.0
-199	TCEANC2	ELLIPSE	20.0	#ffcccc	-278.53	730.48	0.0
-200	NCL	ELLIPSE	20.0	#ffcccc	-250.3	328.88	0.0
-201	WDR61	ELLIPSE	20.0	#ffcccc	5.42	339.39	0.0
-202	C1QBP	ELLIPSE	20.0	#ffcccc	172.22	485.55	0.0
-203	MRPS27	ELLIPSE	20.0	#ffcccc	-97.34	373.64	0.0
-204	FMR1	ELLIPSE	20.0	#ffcccc	-111.85	613.78	0.0
-205	UBAP2L	ELLIPSE	20.0	#ffcccc	107.64	608.79	0.0
-206	MAGED2	ELLIPSE	20.0	#ffcccc	555.43	808.17	0.0
-207	SSBP1	ELLIPSE	20.0	#ffcccc	-36.12	504.5	0.0
-208	GP1BB	ELLIPSE	20.0	#ffcccc	584.78	917.5	0.0
-209	TOMM40	ELLIPSE	20.0	#ffcccc	174.33	1.35	0.0
-210	MCM9	ELLIPSE	20.0	#ffcccc	105.43	688.12	0.0
-211	DDX39B	ELLIPSE	20.0	#ffcccc	-37.55	448.77	0.0
-212	AKAP10	ELLIPSE	20.0	#ffcccc	433.35	1282.12	0.0
-213	PRKAR1B	ELLIPSE	20.0	#ffcccc	461.27	926.74	0.0
-214	TMEM97	ELLIPSE	20.0	#ffcccc	632.75	-546.8	0.0
-215	JADE1	ELLIPSE	20.0	#ffcccc	-747.13	468.51	0.0
-216	YJU2	ELLIPSE	20.0	#ffcccc	-536.75	472.27	0.0
-217	ZPR1	ELLIPSE	20.0	#ffcccc	1239.7	381.39	0.0
-218	IL10RA	ELLIPSE	20.0	#ffcccc	1756.65	172.73	0.0
-219	PTCH2	ELLIPSE	20.0	#ffcccc	680.04	291.37	0.0
-220	MAPK14	ELLIPSE	20.0	#ffcccc	832.72	584.87	0.0
-221	TCF4	ELLIPSE	20.0	#ffcccc	665.07	565.26	0.0
-222	FOXO3	ELLIPSE	20.0	#ffcccc	640.43	846.71	0.0
-223	ESR2	ELLIPSE	20.0	#ffcccc	667.93	612.41	0.0
-224	CBX8	ELLIPSE	20.0	#ffcccc	365.87	486.91	0.0
-225	NCOR2	ELLIPSE	20.0	#ffcccc	651.33	445.76	0.0
-226	ETS2	ELLIPSE	20.0	#ffcccc	602.69	786.56	0.0
-227	BLK	ELLIPSE	20.0	#ffcccc	1118.72	357.3	0.0
-228	KDR	ELLIPSE	20.0	#ffcccc	1125.67	586.11	0.0
-229	CD40LG	ELLIPSE	20.0	#ffcccc	1195.38	255.62	0.0
-230	MEF2C	ELLIPSE	20.0	#ffcccc	548.04	614.04	0.0
-231	MAP2K3	ELLIPSE	20.0	#ffcccc	1080.71	235.14	0.0
-232	ZFAND5	ELLIPSE	20.0	#ffcccc	607.66	-22.62	0.0
-233	PATJ	ELLIPSE	20.0	#ffcccc	986.83	2.31	0.0
-234	TTC31	ELLIPSE	20.0	#ffcccc	-443.84	-166.87	0.0
-235	PTGES3L-AARSD1	ELLIPSE	20.0	#ffcccc	-257.0	-67.12	0.0
-236	FGF23	ELLIPSE	20.0	#ffcccc	1160.17	730.94	0.0
-237	CNTRL	ELLIPSE	20.0	#ffcccc	1203.86	996.58	0.0
-238	MET	ELLIPSE	20.0	#ffcccc	1204.54	460.44	0.0
-239	GDA	ELLIPSE	20.0	#ffcccc	708.32	487.54	0.0
-240	LARS1	ELLIPSE	20.0	#ffcccc	251.98	379.28	0.0
-241	LCMT2	ELLIPSE	20.0	#ffcccc	740.19	698.61	0.0
-242	UPB1	ELLIPSE	20.0	#ffcccc	991.24	-137.98	0.0
-243	IFT81	ELLIPSE	20.0	#ffcccc	1646.75	-135.42	0.0
-244	TRAF3IP1	ELLIPSE	20.0	#ffcccc	1547.29	-23.16	0.0
-245	IFT46	ELLIPSE	20.0	#ffcccc	1684.65	-83.54	0.0
-246	SNRPA	ELLIPSE	20.0	#ffcccc	-399.07	381.54	0.0
-247	HNRNPA3	ELLIPSE	20.0	#ffcccc	-232.62	585.64	0.0
-248	MBNL2	ELLIPSE	20.0	#ffcccc	-646.67	303.96	0.0
-249	FMC1-LUC7L2	ELLIPSE	20.0	#ffcccc	-592.7	465.55	0.0
-250	HNRNPA1	ELLIPSE	20.0	#ffcccc	-45.36	332.23	0.0
-251	SF1	ELLIPSE	20.0	#ffcccc	-268.89	403.47	0.0
-252	SFPQ	ELLIPSE	20.0	#ffcccc	-141.4	497.24	0.0
-253	SART1	ELLIPSE	20.0	#ffcccc	-537.3	381.0	0.0
-254	C4BPB	ELLIPSE	20.0	#ffcccc	1620.53	926.93	0.0
-255	DCTN4	ELLIPSE	20.0	#ffcccc	1459.69	830.36	0.0
-256	MT-CO3	ELLIPSE	20.0	#ffcccc	-258.06	-329.35	0.0
-257	RPL39	ELLIPSE	20.0	#ffcccc	-21.74	139.86	0.0
-258	PPA1	ELLIPSE	20.0	#ffcccc	128.71	-147.82	0.0
-259	LHPP	ELLIPSE	20.0	#ffcccc	89.47	-281.09	0.0
-260	ATP6V0B	ELLIPSE	20.0	#ffcccc	150.1	-374.18	0.0
-261	ATP6AP1	ELLIPSE	20.0	#ffcccc	86.02	-358.46	0.0
-262	PPA2	ELLIPSE	20.0	#ffcccc	70.49	-127.11	0.0
-263	ATP6V1H	ELLIPSE	20.0	#ffcccc	239.25	-230.65	0.0
-264	CFP	ELLIPSE	20.0	#ffcccc	-1443.31	284.32	0.0
-265	ADAMTS18	ELLIPSE	20.0	#ffcccc	-1406.65	226.71	0.0
-266	ADAMTS3	ELLIPSE	20.0	#ffcccc	-1465.25	189.62	0.0
-267	ADAMTSL2	ELLIPSE	20.0	#ffcccc	-1502.33	247.83	0.0
-268	CANX	ELLIPSE	20.0	#ffcccc	603.98	149.28	0.0
-269	RAB40A	ELLIPSE	20.0	#ffcccc	132.38	85.51	0.0
-270	RAB12	ELLIPSE	20.0	#ffcccc	515.5	72.69	0.0
-271	HLA-DRA	ELLIPSE	20.0	#ffcccc	979.61	172.73	0.0
-272	HLA-E	ELLIPSE	20.0	#ffcccc	1060.96	149.16	0.0
-273	TAP2	ELLIPSE	20.0	#ffcccc	842.68	115.98	0.0
-274	VDAC1	ELLIPSE	20.0	#ffcccc	361.5	-170.8	0.0
-275	PIN1	ELLIPSE	20.0	#ffcccc	805.35	678.7	0.0
-276	PPP2R2A	ELLIPSE	20.0	#ffcccc	599.93	692.94	0.0
-277	PPP2R5A	ELLIPSE	20.0	#ffcccc	865.12	830.11	0.0
-278	PRKCD	ELLIPSE	20.0	#ffcccc	1006.95	494.71	0.0
-279	AXIN1	ELLIPSE	20.0	#ffcccc	1020.18	715.62	0.0
-280	JPT2	ELLIPSE	20.0	#ffcccc	303.79	1208.48	0.0
-281	STMN1	ELLIPSE	20.0	#ffcccc	359.23	977.94	0.0
-282	PEX1	ELLIPSE	20.0	#ffcccc	75.57	831.74	0.0
-283	MLLT6	ELLIPSE	20.0	#ffcccc	337.81	1311.64	0.0
-284	ZC3H4	ELLIPSE	20.0	#ffcccc	319.52	1093.16	0.0
-285	CLP1	ELLIPSE	20.0	#ffcccc	-46.07	840.04	0.0
-286	PDXDC1	ELLIPSE	20.0	#ffcccc	253.03	-68.65	0.0
-287	TNS4	ELLIPSE	20.0	#ffcccc	1417.77	388.04	0.0
-288	FUS	ELLIPSE	20.0	#ffcccc	-54.62	612.12	0.0
-289	YEATS2	ELLIPSE	20.0	#ffcccc	-118.9	965.16	0.0
-290	HNRNPA1L2	ELLIPSE	20.0	#ffcccc	-254.05	472.81	0.0
-291	RXRA	ELLIPSE	20.0	#ffcccc	286.39	530.79	0.0
-292	HNRNPUL1	ELLIPSE	20.0	#ffcccc	-343.55	559.36	0.0
-293	SMARCA4	ELLIPSE	20.0	#ffcccc	340.06	553.1	0.0
-294	HSD17B7	ELLIPSE	20.0	#ffcccc	1101.06	1706.19	0.0
-295	TM7SF2	ELLIPSE	20.0	#ffcccc	1136.86	1643.97	0.0
-296	HSD17B12	ELLIPSE	20.0	#ffcccc	1107.79	1815.94	0.0
-297	DHCR24	ELLIPSE	20.0	#ffcccc	1075.46	1533.81	0.0
-298	EEFSEC	ELLIPSE	20.0	#ffcccc	21.39	163.92	0.0
-299	MRPL20	ELLIPSE	20.0	#ffcccc	-65.6	219.42	0.0
-300	DERPC	ELLIPSE	20.0	#ffcccc	161.31	1310.08	0.0
-301	PPP6R3	ELLIPSE	20.0	#ffcccc	207.82	1349.2	0.0
-302	PDE6A	ELLIPSE	20.0	#ffcccc	563.84	-564.58	0.0
-303	BTG1	ELLIPSE	20.0	#ffcccc	754.96	1042.73	0.0
-304	CCNJ	ELLIPSE	20.0	#ffcccc	557.64	1224.59	0.0
-305	MIS18BP1	ELLIPSE	20.0	#ffcccc	488.89	1149.82	0.0
-306	DNMT1	ELLIPSE	20.0	#ffcccc	228.85	834.0	0.0
-307	CNPPD1	ELLIPSE	20.0	#ffcccc	589.43	1149.92	0.0
-308	STIL	ELLIPSE	20.0	#ffcccc	619.76	1221.93	0.0
-309	CDK16	ELLIPSE	20.0	#ffcccc	614.55	1012.06	0.0
-310	RCC1	ELLIPSE	20.0	#ffcccc	391.74	687.14	0.0
-311	CENPU	ELLIPSE	20.0	#ffcccc	435.03	1107.41	0.0
-312	HJURP	ELLIPSE	20.0	#ffcccc	636.68	1080.76	0.0
-313	KIFC1	ELLIPSE	20.0	#ffcccc	1113.78	972.51	0.0
-314	CKAP2	ELLIPSE	20.0	#ffcccc	482.06	1091.36	0.0
-315	NUP42	ELLIPSE	20.0	#ffcccc	17.05	635.47	0.0
-316	SKA3	ELLIPSE	20.0	#ffcccc	529.79	1122.95	0.0
-317	KPNA2	ELLIPSE	20.0	#ffcccc	422.61	867.75	0.0
-318	KIDINS220	ELLIPSE	20.0	#ffcccc	1593.7	648.43	0.0
-319	BDNF	ELLIPSE	20.0	#ffcccc	1381.45	610.98	0.0
-320	ARHGAP9	ELLIPSE	20.0	#ffcccc	1608.68	301.6	0.0
-321	COMMD6	ELLIPSE	20.0	#ffcccc	98.24	909.04	0.0
-322	DCUN1D2	ELLIPSE	20.0	#ffcccc	225.83	789.75	0.0
-323	DCAF17	ELLIPSE	20.0	#ffcccc	173.21	927.21	0.0
-324	H2AC8	ELLIPSE	20.0	#ffcccc	295.46	660.97	0.0
-325	DOCK10	ELLIPSE	20.0	#ffcccc	1639.81	370.69	0.0
-326	NXF1	ELLIPSE	20.0	#ffcccc	-224.37	546.0	0.0
-327	XPOT	ELLIPSE	20.0	#ffcccc	-168.05	798.34	0.0
-328	TBRG4	ELLIPSE	20.0	#ffcccc	95.44	-202.42	0.0
-329	ABHD17C	ELLIPSE	20.0	#ffcccc	1196.17	-686.3	0.0
-330	LYPLA1	ELLIPSE	20.0	#ffcccc	1120.44	-579.18	0.0
-331	MARCHF7	ELLIPSE	20.0	#ffcccc	1060.84	50.78	0.0
-332	USP9X	ELLIPSE	20.0	#ffcccc	927.45	207.01	0.0
-333	ITK	ELLIPSE	20.0	#ffcccc	1262.68	63.3	0.0
-334	RASA1	ELLIPSE	20.0	#ffcccc	1138.39	477.47	0.0
-335	RNF38	ELLIPSE	20.0	#ffcccc	794.11	970.55	0.0
-336	TP63	ELLIPSE	20.0	#ffcccc	716.61	785.78	0.0
-337	HINT2	ELLIPSE	20.0	#ffcccc	-183.15	-439.3	0.0
-338	MAP4K2	ELLIPSE	20.0	#ffcccc	1142.89	228.21	0.0
-339	TRAF3	ELLIPSE	20.0	#ffcccc	1239.45	196.44	0.0
-340	IKBKG	ELLIPSE	20.0	#ffcccc	932.88	90.82	0.0
-341	CHRNA1	ELLIPSE	20.0	#ffcccc	1414.7	915.31	0.0
-342	CHRNA7	ELLIPSE	20.0	#ffcccc	1651.88	1029.76	0.0
-343	CHRM1	ELLIPSE	20.0	#ffcccc	1259.41	1066.85	0.0
-344	CACNG8	ELLIPSE	20.0	#ffcccc	898.7	730.59	0.0
-345	CACNB2	ELLIPSE	20.0	#ffcccc	903.89	628.35	0.0
-346	CNEP1R1	ELLIPSE	20.0	#ffcccc	747.07	886.87	0.0
-347	WNT8A	ELLIPSE	20.0	#ffcccc	1057.3	840.6	0.0
-348	DVL1	ELLIPSE	20.0	#ffcccc	1016.37	907.63	0.0
-349	PPP4R4	ELLIPSE	20.0	#ffcccc	757.3	822.64	0.0
-350	POMT2	ELLIPSE	20.0	#ffcccc	1646.79	745.42	0.0
-351	DPM3	ELLIPSE	20.0	#ffcccc	1900.58	786.84	0.0
-352	KCNQ3	ELLIPSE	20.0	#ffcccc	500.23	430.69	0.0
-353	KCNAB1	ELLIPSE	20.0	#ffcccc	453.24	283.91	0.0
-354	KCNQ4	ELLIPSE	20.0	#ffcccc	388.23	351.83	0.0
-355	RHEB	ELLIPSE	20.0	#ffcccc	233.9	-373.66	0.0
-356	LAMTOR4	ELLIPSE	20.0	#ffcccc	119.38	-328.52	0.0
-357	SCPEP1	ELLIPSE	20.0	#ffcccc	-91.22	-329.26	0.0
-358	GAPVD1	ELLIPSE	20.0	#ffcccc	1144.69	859.15	0.0
-359	CTNNBIP1	ELLIPSE	20.0	#ffcccc	1199.45	875.01	0.0
-360	CSNK1G1	ELLIPSE	20.0	#ffcccc	1105.13	899.74	0.0
-361	CHST8	ELLIPSE	20.0	#ffcccc	2793.9	1678.52	0.0
-362	B4GALNT3	ELLIPSE	20.0	#ffcccc	2718.02	1678.93	0.0
-363	MYH7B	ELLIPSE	20.0	#ffcccc	641.55	-325.63	0.0
-364	ALDOA	ELLIPSE	20.0	#ffcccc	589.21	-170.61	0.0
-365	RPL38	ELLIPSE	20.0	#ffcccc	216.75	331.92	0.0
-366	DNAJC5G	ELLIPSE	20.0	#ffcccc	-611.9	370.92	0.0
-367	MED15	ELLIPSE	20.0	#ffcccc	239.55	668.89	0.0
-368	ANGPTL4	ELLIPSE	20.0	#ffcccc	344.88	624.39	0.0
-369	CDK19	ELLIPSE	20.0	#ffcccc	313.94	712.44	0.0
-370	WDR76	ELLIPSE	20.0	#ffcccc	334.85	-57.17	0.0
-371	GOLGA4	ELLIPSE	20.0	#ffcccc	945.23	767.17	0.0
-372	PLCB4	ELLIPSE	20.0	#ffcccc	1090.6	288.69	0.0
-373	SHC2	ELLIPSE	20.0	#ffcccc	1316.45	549.84	0.0
-374	KIF1B	ELLIPSE	20.0	#ffcccc	1356.08	807.65	0.0
-375	KIF9	ELLIPSE	20.0	#ffcccc	1293.92	979.81	0.0
-376	KIF2A	ELLIPSE	20.0	#ffcccc	1364.27	972.87	0.0
-377	KLC2	ELLIPSE	20.0	#ffcccc	1354.29	882.66	0.0
-378	THOC3	ELLIPSE	20.0	#ffcccc	-324.72	679.6	0.0
-379	SRSF5	ELLIPSE	20.0	#ffcccc	-293.81	607.62	0.0
-380	GAS8	ELLIPSE	20.0	#ffcccc	463.84	711.36	0.0
-381	FLNC	ELLIPSE	20.0	#ffcccc	1768.11	526.89	0.0
-382	SCARB2	ELLIPSE	20.0	#ffcccc	2902.45	391.15	0.0
-383	MGLL	ELLIPSE	20.0	#ffcccc	724.35	1818.0	0.0
-384	AKR1A1	ELLIPSE	20.0	#ffcccc	800.52	1820.32	0.0
-385	ZCRB1	ELLIPSE	20.0	#ffcccc	-273.54	792.87	0.0
-386	ATG5	ELLIPSE	20.0	#ffcccc	361.85	-536.47	0.0
-387	BAK1	ELLIPSE	20.0	#ffcccc	164.69	-226.68	0.0
-388	FKBP8	ELLIPSE	20.0	#ffcccc	368.97	-428.1	0.0
-389	TSPO	ELLIPSE	20.0	#ffcccc	407.86	-383.77	0.0
-390	ALDH8A1	ELLIPSE	20.0	#ffcccc	-716.44	-6.22	0.0
-391	PAH	ELLIPSE	20.0	#ffcccc	-562.12	49.79	0.0
-392	R3HCC1	ELLIPSE	20.0	#ffcccc	2458.77	-235.16	0.0
-393	FAM214B	ELLIPSE	20.0	#ffcccc	2383.36	-239.54	0.0
-394	ARNTL2	ELLIPSE	20.0	#ffcccc	-909.97	-845.97	0.0
-395	NPAS4	ELLIPSE	20.0	#ffcccc	-946.63	-779.53	0.0
-396	SNRNP25	ELLIPSE	20.0	#ffcccc	-316.08	851.23	0.0
-397	UBE2Q2	ELLIPSE	20.0	#ffcccc	648.36	111.32	0.0
-398	UBE2G1	ELLIPSE	20.0	#ffcccc	725.95	115.12	0.0
-399	UBE2F	ELLIPSE	20.0	#ffcccc	621.21	201.36	0.0
-400	SEPTIN12	ELLIPSE	20.0	#ffcccc	-939.77	1773.55	0.0
-401	TMEM250	ELLIPSE	20.0	#ffcccc	-879.76	1817.13	0.0
-402	MTRF1L	ELLIPSE	20.0	#ffcccc	-70.49	135.01	0.0
-403	OSTC	ELLIPSE	20.0	#ffcccc	343.36	244.06	0.0
-404	C18orf32	ELLIPSE	20.0	#ffcccc	99.63	352.69	0.0
-405	RPL36A	ELLIPSE	20.0	#ffcccc	-17.39	371.53	0.0
-406	EIF6	ELLIPSE	20.0	#ffcccc	-46.25	272.37	0.0
-407	APOBEC3A	ELLIPSE	20.0	#ffcccc	-181.42	-34.86	0.0
-408	APOBEC3G	ELLIPSE	20.0	#ffcccc	-138.0	-27.41	0.0
-409	CHCHD6	ELLIPSE	20.0	#ffcccc	33.31	-84.1	0.0
-410	SDHD	ELLIPSE	20.0	#ffcccc	28.98	-400.29	0.0
-411	CFAP45	ELLIPSE	20.0	#ffcccc	179.64	538.19	0.0
-412	H1-10	ELLIPSE	20.0	#ffcccc	400.43	611.17	0.0
-413	CASP8AP2	ELLIPSE	20.0	#ffcccc	467.55	567.24	0.0
-414	LRRC56	ELLIPSE	20.0	#ffcccc	1070.55	1360.02	0.0
-415	SUOX	ELLIPSE	20.0	#ffcccc	1026.63	1173.24	0.0
-416	CACNA1G	ELLIPSE	20.0	#ffcccc	799.4	733.12	0.0
-417	GRIK1	ELLIPSE	20.0	#ffcccc	865.34	656.14	0.0
-418	GRID2	ELLIPSE	20.0	#ffcccc	972.63	714.33	0.0
-419	EPB41L1	ELLIPSE	20.0	#ffcccc	1044.27	761.31	0.0
-420	POGZ	ELLIPSE	20.0	#ffcccc	706.61	1457.43	0.0
-421	NRF1	ELLIPSE	20.0	#ffcccc	670.89	1598.49	0.0
-422	CHAMP1	ELLIPSE	20.0	#ffcccc	743.26	1594.18	0.0
-423	PELO	ELLIPSE	20.0	#ffcccc	106.87	295.64	0.0
-424	ANXA6	ELLIPSE	20.0	#ffcccc	1345.89	457.17	0.0
-425	GPR174	ELLIPSE	20.0	#ffcccc	1198.32	-9.34	0.0
-426	INPPL1	ELLIPSE	20.0	#ffcccc	1188.91	152.98	0.0
-427	PLD4	ELLIPSE	20.0	#ffcccc	1067.93	-311.96	0.0
-428	GRAP2	ELLIPSE	20.0	#ffcccc	1150.99	122.48	0.0
-429	GNRH1	ELLIPSE	20.0	#ffcccc	1493.8	1325.1	0.0
-430	CCK	ELLIPSE	20.0	#ffcccc	1361.98	1272.42	0.0
-431	EDN3	ELLIPSE	20.0	#ffcccc	1442.58	1234.6	0.0
-432	LRP12	ELLIPSE	20.0	#ffcccc	-1516.95	-474.15	0.0
-433	GPC2	ELLIPSE	20.0	#ffcccc	-1595.68	-461.09	0.0
-434	LIN7C	ELLIPSE	20.0	#ffcccc	1095.27	-180.07	0.0
-435	IBTK	ELLIPSE	20.0	#ffcccc	-479.33	798.85	0.0
-436	DNAJC1	ELLIPSE	20.0	#ffcccc	80.33	233.6	0.0
-437	GPM6A	ELLIPSE	20.0	#ffcccc	931.05	1190.73	0.0
-438	SYNPR	ELLIPSE	20.0	#ffcccc	1183.12	1216.87	0.0
-439	SLC6A1	ELLIPSE	20.0	#ffcccc	1130.84	1263.56	0.0
-440	NGLY1	ELLIPSE	20.0	#ffcccc	878.3	-52.34	0.0
-441	ITM2B	ELLIPSE	20.0	#ffcccc	970.99	-226.53	0.0
-442	UBXN1	ELLIPSE	20.0	#ffcccc	810.44	-66.79	0.0
-443	AMFR	ELLIPSE	20.0	#ffcccc	795.18	64.19	0.0
-444	FER	ELLIPSE	20.0	#ffcccc	1477.71	619.4	0.0
-445	SCLT1	ELLIPSE	20.0	#ffcccc	-580.81	1822.61	0.0
-446	FBF1	ELLIPSE	20.0	#ffcccc	-505.44	1822.82	0.0
-447	DONSON	ELLIPSE	20.0	#ffcccc	400.08	1353.49	0.0
-448	GADL1	ELLIPSE	20.0	#ffcccc	1175.04	-270.27	0.0
-449	CARNS1	ELLIPSE	20.0	#ffcccc	1130.21	-308.06	0.0
-450	SCN3A	ELLIPSE	20.0	#ffcccc	777.97	591.17	0.0
-451	SCN3B	ELLIPSE	20.0	#ffcccc	722.18	628.16	0.0
-452	SCN1B	ELLIPSE	20.0	#ffcccc	722.1	571.91	0.0
-453	LPCAT1	ELLIPSE	20.0	#ffcccc	1116.31	-469.9	0.0
-454	PLA2G4E	ELLIPSE	20.0	#ffcccc	992.89	-468.76	0.0
-455	PLD3	ELLIPSE	20.0	#ffcccc	1012.82	-375.36	0.0
-456	PLA2G10	ELLIPSE	20.0	#ffcccc	1032.59	-467.76	0.0
-457	RBM10	ELLIPSE	20.0	#ffcccc	-431.6	264.85	0.0
-458	TSEN2	ELLIPSE	20.0	#ffcccc	24.26	815.59	0.0
-459	PRKRA	ELLIPSE	20.0	#ffcccc	47.09	957.09	0.0
-460	AGO4	ELLIPSE	20.0	#ffcccc	300.85	816.14	0.0
-461	ERN1	ELLIPSE	20.0	#ffcccc	121.64	945.78	0.0
-462	ODF1	ELLIPSE	20.0	#ffcccc	402.14	-79.55	0.0
-463	BUB3	ELLIPSE	20.0	#ffcccc	119.88	552.21	0.0
-464	FKBP9	ELLIPSE	20.0	#ffcccc	492.58	-91.9	0.0
-465	GBA	ELLIPSE	20.0	#ffcccc	480.83	-197.61	0.0
-466	CPNE6	ELLIPSE	20.0	#ffcccc	1279.48	1312.08	0.0
-467	SNAP91	ELLIPSE	20.0	#ffcccc	1147.66	1070.13	0.0
-468	SNCB	ELLIPSE	20.0	#ffcccc	1308.13	1205.51	0.0
-469	LY6H	ELLIPSE	20.0	#ffcccc	1227.4	1280.05	0.0
-470	BRWD3	ELLIPSE	20.0	#ffcccc	837.95	166.31	0.0
-471	HM13	ELLIPSE	20.0	#ffcccc	652.84	247.19	0.0
-472	CSPG5	ELLIPSE	20.0	#ffcccc	-1675.38	-452.07	0.0
-473	TMEM14C	ELLIPSE	20.0	#ffcccc	-43.6	-497.87	0.0
-474	TMEM256	ELLIPSE	20.0	#ffcccc	-86.58	-458.54	0.0
-475	COX14	ELLIPSE	20.0	#ffcccc	-272.42	-396.15	0.0
-476	MAML1	ELLIPSE	20.0	#ffcccc	607.47	628.97	0.0
-477	HDAC9	ELLIPSE	20.0	#ffcccc	464.0	646.0	0.0
-478	SHLD3	ELLIPSE	20.0	#ffcccc	263.72	43.07	0.0
-479	FBXL19	ELLIPSE	20.0	#ffcccc	228.83	230.46	0.0
-480	BTBD9	ELLIPSE	20.0	#ffcccc	882.77	-254.59	0.0
-481	UBXN6	ELLIPSE	20.0	#ffcccc	732.62	-302.01	0.0
-482	TRAPPC1	ELLIPSE	20.0	#ffcccc	1064.09	480.46	0.0
-483	DNAI3	ELLIPSE	20.0	#ffcccc	-187.82	632.66	0.0
-484	CCDC114	ELLIPSE	20.0	#ffcccc	14.64	509.68	0.0
-485	FABP1	ELLIPSE	20.0	#ffcccc	498.67	494.63	0.0
-486	RGL1	ELLIPSE	20.0	#ffcccc	438.61	516.58	0.0
-487	CHD9	ELLIPSE	20.0	#ffcccc	391.33	432.01	0.0
-488	ADH5	ELLIPSE	20.0	#ffcccc	618.8	-938.98	0.0
-489	NKD2	ELLIPSE	20.0	#ffcccc	1076.69	1117.99	0.0
-490	RP9	ELLIPSE	20.0	#ffcccc	-749.29	345.18	0.0
-491	RPP25L	ELLIPSE	20.0	#ffcccc	-523.51	719.25	0.0
-492	ELP2	ELLIPSE	20.0	#ffcccc	-530.47	-63.07	0.0
-493	MINPP1	ELLIPSE	20.0	#ffcccc	987.63	87.97	0.0
-494	RXFP2	ELLIPSE	20.0	#ffcccc	1921.95	-662.91	0.0
-495	RXFP1	ELLIPSE	20.0	#ffcccc	1957.38	-731.24	0.0
-496	STAT6	ELLIPSE	20.0	#ffcccc	1110.7	-14.55	0.0
-497	KCTD5	ELLIPSE	20.0	#ffcccc	497.22	1352.14	0.0
-498	KCTD2	ELLIPSE	20.0	#ffcccc	535.04	1303.12	0.0
-499	KLHL12	ELLIPSE	20.0	#ffcccc	645.46	1176.16	0.0
-500	KLHL2	ELLIPSE	20.0	#ffcccc	382.35	1147.31	0.0
-501	TONSL	ELLIPSE	20.0	#ffcccc	335.56	895.85	0.0
-502	H2BC8	ELLIPSE	20.0	#ffcccc	277.06	775.26	0.0
-503	OR52A5	ELLIPSE	20.0	#ffcccc	883.04	1055.03	0.0
-504	GNAL	ELLIPSE	20.0	#ffcccc	914.07	965.4	0.0
-505	CNOT4	ELLIPSE	20.0	#ffcccc	335.86	383.54	0.0
-506	IPO11	ELLIPSE	20.0	#ffcccc	610.35	46.34	0.0
-507	TRIM32	ELLIPSE	20.0	#ffcccc	688.34	148.76	0.0
-508	ABR	ELLIPSE	20.0	#ffcccc	1608.35	489.95	0.0
-509	REV3L	ELLIPSE	20.0	#ffcccc	746.09	274.53	0.0
-510	CHMP7	ELLIPSE	20.0	#ffcccc	309.17	192.43	0.0
-511	CHMP6	ELLIPSE	20.0	#ffcccc	307.92	129.37	0.0
-512	ZUP1	ELLIPSE	20.0	#ffcccc	761.37	1193.29	0.0
-513	RAD51B	ELLIPSE	20.0	#ffcccc	477.94	844.68	0.0
-514	XRCC3	ELLIPSE	20.0	#ffcccc	511.29	1030.69	0.0
-515	GAA	ELLIPSE	20.0	#ffcccc	679.16	-363.84	0.0
-516	ASAH1	ELLIPSE	20.0	#ffcccc	602.23	-405.11	0.0
-517	AMY2B	ELLIPSE	20.0	#ffcccc	815.59	-440.94	0.0
-518	GKAP1	ELLIPSE	20.0	#ffcccc	-643.18	868.68	0.0
-519	LPAR4	ELLIPSE	20.0	#ffcccc	1140.34	1151.58	0.0
-520	LPAR1	ELLIPSE	20.0	#ffcccc	1251.55	1206.74	0.0
-521	KANSL2	ELLIPSE	20.0	#ffcccc	-284.68	1140.08	0.0
-522	MBIP	ELLIPSE	20.0	#ffcccc	-232.04	1175.23	0.0
-523	SGF29	ELLIPSE	20.0	#ffcccc	-299.21	1240.53	0.0
-524	MLLT10	ELLIPSE	20.0	#ffcccc	297.31	1488.39	0.0
-525	SRPK3	ELLIPSE	20.0	#ffcccc	-508.01	640.08	0.0
-526	HTATSF1	ELLIPSE	20.0	#ffcccc	-664.0	595.35	0.0
-527	ZRSR2P1	ELLIPSE	20.0	#ffcccc	-669.84	520.44	0.0
-528	VSNL1	ELLIPSE	20.0	#ffcccc	1421.3	1364.16	0.0
-529	CEND1	ELLIPSE	20.0	#ffcccc	1344.91	1388.6	0.0
-530	MAP3K11	ELLIPSE	20.0	#ffcccc	1307.49	215.34	0.0
-531	ECT2L	ELLIPSE	20.0	#ffcccc	489.02	1245.04	0.0
-532	ARR3	ELLIPSE	20.0	#ffcccc	1653.32	438.99	0.0
-533	ZMIZ2	ELLIPSE	20.0	#ffcccc	359.49	754.62	0.0
-534	LCN15	ELLIPSE	20.0	#ffcccc	3031.1	1488.88	0.0
-535	ATG4A	ELLIPSE	20.0	#ffcccc	3080.22	1548.69	0.0
-536	CERS5	ELLIPSE	20.0	#ffcccc	546.09	-439.23	0.0
-537	PSAP	ELLIPSE	20.0	#ffcccc	484.97	-422.96	0.0
-538	ARL4C	ELLIPSE	20.0	#ffcccc	521.06	673.66	0.0
-539	SGIP1	ELLIPSE	20.0	#ffcccc	1079.59	688.02	0.0
-540	C1orf122	ELLIPSE	20.0	#ffcccc	-402.87	1341.46	0.0
-541	ATXN7L1	ELLIPSE	20.0	#ffcccc	-338.79	1382.7	0.0
-542	DLGAP1	ELLIPSE	20.0	#ffcccc	1321.04	370.47	0.0
-543	ANP32B	ELLIPSE	20.0	#ffcccc	-615.04	205.8	0.0
-544	CFAP299	ELLIPSE	20.0	#ffcccc	-5.08	586.0	0.0
-545	CD6	ELLIPSE	20.0	#ffcccc	1398.77	-103.07	0.0
-546	OR10K2	ELLIPSE	20.0	#ffcccc	972.41	1089.86	0.0
-547	CPVL	ELLIPSE	20.0	#ffcccc	721.76	-164.18	0.0
-548	PHF21B	ELLIPSE	20.0	#ffcccc	398.64	146.79	0.0
-549	ENSA	ELLIPSE	20.0	#ffcccc	673.73	912.72	0.0
-550	FBN1	ELLIPSE	20.0	#ffcccc	2114.43	1674.94	0.0
-551	MFAP5	ELLIPSE	20.0	#ffcccc	2044.6	1712.75	0.0
-552	ELN	ELLIPSE	20.0	#ffcccc	2049.23	1633.69	0.0
-553	SETD3	ELLIPSE	20.0	#ffcccc	1444.43	551.0	0.0
-554	BPHL	ELLIPSE	20.0	#ffcccc	1652.93	571.56	0.0
-555	MYO9B	ELLIPSE	20.0	#ffcccc	583.19	-105.46	0.0
-556	EIF4G2	ELLIPSE	20.0	#ffcccc	-20.23	211.6	0.0
-557	ATP11C	ELLIPSE	20.0	#ffcccc	930.23	-21.5	0.0
-558	KIF19	ELLIPSE	20.0	#ffcccc	1325.62	1039.63	0.0
-559	OR3A2	ELLIPSE	20.0	#ffcccc	1015.35	991.53	0.0
-560	OR8G1	ELLIPSE	20.0	#ffcccc	949.51	1037.64	0.0
-561	OR2T5	ELLIPSE	20.0	#ffcccc	915.31	1096.27	0.0
-562	OR2T7	ELLIPSE	20.0	#ffcccc	1007.31	1046.81	0.0
-563	LIMK1	ELLIPSE	20.0	#ffcccc	1388.07	724.56	0.0
-564	LIPA	ELLIPSE	20.0	#ffcccc	1037.48	1646.86	0.0
-565	SUV39H1	ELLIPSE	20.0	#ffcccc	220.78	627.02	0.0
-566	KDM2B	ELLIPSE	20.0	#ffcccc	140.7	786.19	0.0
-567	PBDC1	ELLIPSE	20.0	#ffcccc	-282.71	130.23	0.0
-568	ADA	ELLIPSE	20.0	#ffcccc	-445.98	186.69	0.0
-569	IFNAR2	ELLIPSE	20.0	#ffcccc	929.53	145.15	0.0
-570	TREM2	ELLIPSE	20.0	#ffcccc	1268.28	149.68	0.0
-571	TNRC6A	ELLIPSE	20.0	#ffcccc	538.86	730.43	0.0
-572	TNRC6B	ELLIPSE	20.0	#ffcccc	487.93	784.92	0.0
-573	GTF3A	ELLIPSE	20.0	#ffcccc	228.85	708.04	0.0
-574	COL17A1	ELLIPSE	20.0	#ffcccc	-1365.74	852.5	0.0
-575	P4HA3	ELLIPSE	20.0	#ffcccc	-1366.9	928.46	0.0
-576	NABP1	ELLIPSE	20.0	#ffcccc	-286.72	901.12	0.0
-577	NFIA	ELLIPSE	20.0	#ffcccc	-241.77	869.47	0.0
-578	FNIP1	ELLIPSE	20.0	#ffcccc	197.05	-456.05	0.0
-579	TAOK3	ELLIPSE	20.0	#ffcccc	1318.64	101.75	0.0
-580	MAP3K15	ELLIPSE	20.0	#ffcccc	1459.95	267.05	0.0
-581	TNFSF13B	ELLIPSE	20.0	#ffcccc	1382.26	280.81	0.0
-582	STIM2	ELLIPSE	20.0	#ffcccc	1646.37	176.7	0.0
-583	ANP32A	ELLIPSE	20.0	#ffcccc	-773.66	159.99	0.0
-584	SYNJ2	ELLIPSE	20.0	#ffcccc	1012.94	317.42	0.0
-585	PIP5KL1	ELLIPSE	20.0	#ffcccc	1177.06	304.23	0.0
-586	WSB2	ELLIPSE	20.0	#ffcccc	-69.71	795.54	0.0
-587	BTBD6	ELLIPSE	20.0	#ffcccc	56.17	1079.22	0.0
-588	CCDC93	ELLIPSE	20.0	#ffcccc	3.47	1155.38	0.0
-589	MCF2L	ELLIPSE	20.0	#ffcccc	1562.74	349.45	0.0
-590	WNT5B	ELLIPSE	20.0	#ffcccc	1156.91	795.88	0.0
-591	ARID5A	ELLIPSE	20.0	#ffcccc	419.76	754.35	0.0
-592	GMPPA	ELLIPSE	20.0	#ffcccc	2010.06	846.0	0.0
-593	LOXL2	ELLIPSE	20.0	#ffcccc	1979.43	1669.62	0.0
-594	TRPC4	ELLIPSE	20.0	#ffcccc	854.47	903.92	0.0
-595	RNASEK	ELLIPSE	20.0	#ffcccc	140.28	-478.56	0.0
-596	TOPORS	ELLIPSE	20.0	#ffcccc	-1096.03	-382.92	0.0
-597	BLOC1S2	ELLIPSE	20.0	#ffcccc	-1135.85	-317.18	0.0
-598	GBE1	ELLIPSE	20.0	#ffcccc	895.94	-320.38	0.0
-599	COA3	ELLIPSE	20.0	#ffcccc	-371.88	-450.78	0.0
-600	SENP6	ELLIPSE	20.0	#ffcccc	79.14	1319.33	0.0
-601	SIPA1L2	ELLIPSE	20.0	#ffcccc	3377.62	-247.61	0.0
-602	DYRK1B	ELLIPSE	20.0	#ffcccc	3449.34	-222.62	0.0
-603	IBA57	ELLIPSE	20.0	#ffcccc	-349.85	-210.3	0.0
-604	PSEN2	ELLIPSE	20.0	#ffcccc	11.54	1258.68	0.0
-605	RYR3	ELLIPSE	20.0	#ffcccc	-49.05	1419.22	0.0
-606	DYNLT1	ELLIPSE	20.0	#ffcccc	1550.9	740.89	0.0
-607	PTGS2	ELLIPSE	20.0	#ffcccc	1023.27	-601.6	0.0
-608	ALOX15B	ELLIPSE	20.0	#ffcccc	932.04	-632.59	0.0
-609	NAXE	ELLIPSE	20.0	#ffcccc	920.72	-494.94	0.0
-610	DOLPP1	ELLIPSE	20.0	#ffcccc	2024.35	765.59	0.0
-611	KCTD20	ELLIPSE	20.0	#ffcccc	-9.13	748.0	0.0
-612	TECPR1	ELLIPSE	20.0	#ffcccc	349.43	-715.71	0.0
-613	STRIP1	ELLIPSE	20.0	#ffcccc	3444.39	925.38	0.0
-614	STK26	ELLIPSE	20.0	#ffcccc	3396.27	988.22	0.0
-615	CPEB3	ELLIPSE	20.0	#ffcccc	-361.53	744.46	0.0
-616	ADGRL4	ELLIPSE	20.0	#ffcccc	3031.49	319.55	0.0
-617	BAIAP2L2	ELLIPSE	20.0	#ffcccc	1266.61	760.74	0.0
-618	PLEKHG5	ELLIPSE	20.0	#ffcccc	1158.3	-152.63	0.0
-619	HTD2	ELLIPSE	20.0	#ffcccc	-750.92	1250.47	0.0
-620	HADH	ELLIPSE	20.0	#ffcccc	-795.21	1177.41	0.0
-621	FOXO6	ELLIPSE	20.0	#ffcccc	700.67	1062.6	0.0
-622	CLNS1A	ELLIPSE	20.0	#ffcccc	69.33	-436.77	0.0
-623	NFKBIL1	ELLIPSE	20.0	#ffcccc	1071.67	1032.96	0.0
-624	IFITM3	ELLIPSE	20.0	#ffcccc	1240.84	-58.69	0.0
-625	IFITM1	ELLIPSE	20.0	#ffcccc	1281.16	-11.07	0.0
-626	SRM	ELLIPSE	20.0	#ffcccc	113.89	147.56	0.0
-627	GPX8	ELLIPSE	20.0	#ffcccc	743.84	-765.04	0.0
-628	BTBD3	ELLIPSE	20.0	#ffcccc	-57.56	1264.15	0.0
-629	PGM5	ELLIPSE	20.0	#ffcccc	870.48	69.19	0.0
-630	MON2	ELLIPSE	20.0	#ffcccc	573.84	-231.54	0.0
-631	ONECUT2	ELLIPSE	20.0	#ffcccc	1000.17	1353.78	0.0
-632	SYNPO	ELLIPSE	20.0	#ffcccc	1244.79	552.53	0.0
-633	CAB39L	ELLIPSE	20.0	#ffcccc	3336.78	1040.25	0.0
-634	VARS2	ELLIPSE	20.0	#ffcccc	239.81	509.76	0.0
-635	PBRM1	ELLIPSE	20.0	#ffcccc	651.85	340.97	0.0
-636	CLDN3	ELLIPSE	20.0	#ffcccc	-190.06	1816.72	0.0
-637	CLDN2	ELLIPSE	20.0	#ffcccc	-264.83	1820.16	0.0
-638	CTSV	ELLIPSE	20.0	#ffcccc	1143.06	38.64	0.0
-639	SOCS4	ELLIPSE	20.0	#ffcccc	-289.62	507.61	0.0
-640	ELP5	ELLIPSE	20.0	#ffcccc	-668.15	-146.43	0.0
-641	CDH18	ELLIPSE	20.0	#ffcccc	1464.48	679.0	0.0
-642	PCBP4	ELLIPSE	20.0	#ffcccc	697.59	1002.21	0.0
-643	SFTPB	ELLIPSE	20.0	#ffcccc	-1611.26	1541.49	0.0
-644	SFTA3	ELLIPSE	20.0	#ffcccc	-1648.18	1608.67	0.0
-645	AMDHD2	ELLIPSE	20.0	#ffcccc	-1205.11	1681.73	0.0
-646	NAGK	ELLIPSE	20.0	#ffcccc	-1279.88	1695.68	0.0
-647	ANKRD36	ELLIPSE	20.0	#ffcccc	148.17	1820.36	0.0
-648	ANKRD36C	ELLIPSE	20.0	#ffcccc	71.96	1821.19	0.0
-649	ATP2B1	ELLIPSE	20.0	#ffcccc	780.09	-207.44	0.0
-650	PRRT2	ELLIPSE	20.0	#ffcccc	1432.93	-41.02	0.0
-651	LYNX1	ELLIPSE	20.0	#ffcccc	1783.89	1090.27	0.0
-652	ZNF598	ELLIPSE	20.0	#ffcccc	665.56	709.0	0.0
-653	GLRA1	ELLIPSE	20.0	#ffcccc	1716.95	-850.49	0.0
-654	GABRR3	ELLIPSE	20.0	#ffcccc	1657.88	-896.67	0.0
-655	DNAH11	ELLIPSE	20.0	#ffcccc	1660.73	871.79	0.0
-656	AZI2	ELLIPSE	20.0	#ffcccc	1033.33	-87.28	0.0
-657	CRYAB	ELLIPSE	20.0	#ffcccc	-30.87	953.53	0.0
-658	HSPB6	ELLIPSE	20.0	#ffcccc	-139.23	1136.78	0.0
-659	ERC1	ELLIPSE	20.0	#ffcccc	1094.38	-85.79	0.0
\ No newline at end of file
diff --git a/results/plots_paper/Table_1.ods b/results/plots_paper/Table_1.ods
new file mode 100644
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diff --git a/results/tables/gwas_intersection.csv b/results/tables/gwas_intersection.csv
new file mode 100644
index 0000000..8359231
--- /dev/null
+++ b/results/tables/gwas_intersection.csv
@@ -0,0 +1,14 @@
+association_id,variant_id,risk_allele,risk_frequency,genome_wide,pvalue,pvalue_description,range,beta_number,beta_direction,chromosome_name,chromosome_position,functional_class,ensembl_gene_name,hgnc_symbol,group,type
+41136253,rs58621819,T,0.2097,FALSE,2e-10,NA,[1.01-1.02],NA,NA,11,65547359,intron_variant,ENSG00000168056,LTBP3,OFC_female,DGE
+41136409,rs12923444,C,0.4375,FALSE,2e-24,NA,[1.02-1.03],NA,NA,16,21628389,intron_variant,ENSG00000197006,METTL9,OFC_female,DGE
+41135995,rs10789214,T,0.5661,FALSE,4e-10,NA,[1.009-1.018],NA,NA,1,66681134,intron_variant,ENSG00000118473,SGIP1,OFC_female,DTE
+41136026,rs17641524,C,0.7909,FALSE,8e-20,NA,[1.02-1.03],NA,NA,1,197735587,splice_region_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
+41136085,rs45510091,A,0.9472,FALSE,8e-21,NA,[1.037-1.057],NA,NA,4,122265238,intron_variant,ENSG00000138688,BLTP1,Cg25_male,DGE
+30547745,rs10127497,T,0.1382,FALSE,1e-08,NA,[0.0064-0.013],0.0097,increase,1,66584461,intron_variant,ENSG00000118473,SGIP1,OFC_female,DTE
+30547749,rs6679379,T,0.2875,FALSE,3e-08,NA,[0.0047-0.0097],0.0072,increase,1,66733473,non_coding_transcript_exon_variant,ENSG00000118473,SGIP1,OFC_female,DTE
+30547797,rs12118513,A,0.2148,FALSE,1e-07,NA,[0.0049-0.0103],0.0076,decrease,1,197547956,intron_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
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diff --git a/results/tables/intersect_by_type_and_gwas.csv b/results/tables/intersect_by_type_and_gwas.csv
new file mode 100644
index 0000000..f59842b
--- /dev/null
+++ b/results/tables/intersect_by_type_and_gwas.csv
@@ -0,0 +1,1215 @@
+intersect.x,genes.x,hgnc_symbol,gene,group,region,sex,type,intersect.y,genes.y,gwas
+female:male,ENSG00000185149,NPY2R,ENSG00000185149,Nac_female,Nac,female,DGE,DGE,ENSG00000185149,not_gwas
+female:male,ENSG00000185149,NPY2R,ENSG00000185149,Sub_male,Sub,male,DGE,DGE,ENSG00000185149,not_gwas
+female:male,ENSG00000118972,FGF23,ENSG00000118972,OFC_male,OFC,male,DGE,DGE:DTE,ENSG00000118972,not_gwas
+female:male,ENSG00000118972,FGF23,ENSG00000118972,OFC_female,OFC,female,DGE,DGE:DTE,ENSG00000118972,not_gwas
+female:male,ENSG00000118972,FGF23,ENSG00000118972,Cg25_female,Cg25,female,DGE,DGE:DTE,ENSG00000118972,not_gwas
+female:male,ENSG00000118972,FGF23,ENSG00000118972,OFC_male,OFC,male,DTE,DGE:DTE,ENSG00000118972,not_gwas
+female:male,ENSG00000118972,FGF23,ENSG00000118972,OFC_female,OFC,female,DTE,DGE:DTE,ENSG00000118972,not_gwas
+female:male,ENSG00000118972,FGF23,ENSG00000118972,Cg25_female,Cg25,female,DTE,DGE:DTE,ENSG00000118972,not_gwas
+female:male,ENSG00000131469,RPL27,ENSG00000131469,OFC_female,OFC,female,DGE,DGE:DTE,ENSG00000131469,not_gwas
+female:male,ENSG00000131469,RPL27,ENSG00000131469,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000131469,not_gwas
+female:male,ENSG00000131469,RPL27,ENSG00000131469,OFC_female,OFC,female,DTE,DGE:DTE,ENSG00000131469,not_gwas
+female:male,ENSG00000131469,RPL27,ENSG00000131469,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000131469,not_gwas
+female:male,ENSG00000185710,SMG1P4,ENSG00000185710,OFC_female,OFC,female,DGE,DGE,ENSG00000185710,not_gwas
+female:male,ENSG00000185710,SMG1P4,ENSG00000185710,Cg25_male,Cg25,male,DGE,DGE,ENSG00000185710,not_gwas
+female:male,ENSG00000134884,ARGLU1,ENSG00000134884,OFC_female,OFC,female,DGE,DGE:DTE,ENSG00000134884,not_gwas
+female:male,ENSG00000134884,ARGLU1,ENSG00000134884,OFC_male,OFC,male,DTE,DGE:DTE,ENSG00000134884,not_gwas
+female:male,ENSG00000134884,ARGLU1,ENSG00000134884,OFC_female,OFC,female,DTE,DGE:DTE,ENSG00000134884,not_gwas
+female:male,ENSG00000105223,PLD3,ENSG00000105223,OFC_female,OFC,female,DGE,DGE,ENSG00000105223,not_gwas
+female:male,ENSG00000105223,PLD3,ENSG00000105223,Cg25_male,Cg25,male,DGE,DGE,ENSG00000105223,not_gwas
+female:male,ENSG00000181804,SLC9A9,ENSG00000181804,OFC_female,OFC,female,DGE,DGE,ENSG00000181804,not_gwas
+female:male,ENSG00000181804,SLC9A9,ENSG00000181804,Cg25_male,Cg25,male,DGE,DGE,ENSG00000181804,not_gwas
+female:male,ENSG00000198563,DDX39B,ENSG00000198563,OFC_female,OFC,female,DGE,DGE,ENSG00000198563,not_gwas
+female:male,ENSG00000198563,DDX39B,ENSG00000198563,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000198563,not_gwas
+female:male,ENSG00000198563,DDX39B,ENSG00000198563,Cg25_female,Cg25,female,DGE,DGE,ENSG00000198563,not_gwas
+female:male,ENSG00000198563,DDX39B,ENSG00000198563,aINS_female,aINS,female,DGE,DGE,ENSG00000198563,not_gwas
+female:male,ENSG00000198563,DDX39B,ENSG00000198563,Sub_male,Sub,male,DGE,DGE,ENSG00000198563,not_gwas
+female:male,ENSG00000135766,EGLN1,ENSG00000135766,OFC_female,OFC,female,DGE,DGE,ENSG00000135766,not_gwas
+female:male,ENSG00000135766,EGLN1,ENSG00000135766,Cg25_male,Cg25,male,DGE,DGE,ENSG00000135766,not_gwas
+female:male,ENSG00000227152,OR2T7,ENSG00000227152,OFC_female,OFC,female,DGE,DGE:DTU,ENSG00000227152,not_gwas
+female:male,ENSG00000227152,OR2T7,ENSG00000227152,Sub_male,Sub,male,DTU,DGE:DTU,ENSG00000227152,not_gwas
+female:male,ENSG00000213816,CNN2P4,ENSG00000213816,OFC_female,OFC,female,DGE,DGE,ENSG00000213816,not_gwas
+female:male,ENSG00000213816,CNN2P4,ENSG00000213816,Sub_male,Sub,male,DGE,DGE,ENSG00000213816,not_gwas
+female:male,ENSG00000237649,KIFC1,ENSG00000237649,Cg25_male,Cg25,male,DGE,DGE,ENSG00000237649,not_gwas
+female:male,ENSG00000237649,KIFC1,ENSG00000237649,Cg25_female,Cg25,female,DGE,DGE,ENSG00000237649,not_gwas
+female:male,ENSG00000178397,FAM220A,ENSG00000178397,Nac_female,Nac,female,DTE,DTE,ENSG00000178397,not_gwas
+female:male,ENSG00000178397,FAM220A,ENSG00000178397,OFC_male,OFC,male,DTE,DTE,ENSG00000178397,not_gwas
+female:male,ENSG00000178397,FAM220A,ENSG00000178397,aINS_male,aINS,male,DTE,DTE,ENSG00000178397,not_gwas
+female:male,ENSG00000128564,VGF,ENSG00000128564,Nac_female,Nac,female,DTE,DTE:DTU,ENSG00000128564,not_gwas
+female:male,ENSG00000128564,VGF,ENSG00000128564,OFC_male,OFC,male,DTU,DTE:DTU,ENSG00000128564,not_gwas
+female:male,ENSG00000156097,GPR61,ENSG00000156097,Nac_male,Nac,male,DTE,DTE,ENSG00000156097,not_gwas
+female:male,ENSG00000156097,GPR61,ENSG00000156097,OFC_female,OFC,female,DTE,DTE,ENSG00000156097,not_gwas
+female:male,ENSG00000145757,SPATA9,ENSG00000145757,OFC_female,OFC,female,DTE,DTE:DTU,ENSG00000145757,not_gwas
+female:male,ENSG00000145757,SPATA9,ENSG00000145757,Nac_male,Nac,male,DTU,DTE:DTU,ENSG00000145757,not_gwas
+female:male,ENSG00000188089,PLA2G4E,ENSG00000188089,OFC_male,OFC,male,DTE,DTE,ENSG00000188089,not_gwas
+female:male,ENSG00000188089,PLA2G4E,ENSG00000188089,OFC_female,OFC,female,DTE,DTE,ENSG00000188089,not_gwas
+female:male,ENSG00000230601,TEX48,ENSG00000230601,Nac_male,Nac,male,DTE,DTE,ENSG00000230601,not_gwas
+female:male,ENSG00000230601,TEX48,ENSG00000230601,OFC_female,OFC,female,DTE,DTE,ENSG00000230601,not_gwas
+female:male,ENSG00000099960,SLC7A4,ENSG00000099960,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000099960,not_gwas
+female:male,ENSG00000099960,SLC7A4,ENSG00000099960,aINS_female,aINS,female,DTE,DTE,ENSG00000099960,not_gwas
+female:male,ENSG00000099331,MYO9B,ENSG00000099331,Sub_male,Sub,male,DTE,DTE,ENSG00000099331,not_gwas
+female:male,ENSG00000099331,MYO9B,ENSG00000099331,Sub_female,Sub,female,DTE,DTE,ENSG00000099331,not_gwas
+female:male,ENSG00000242114,MTFP1,ENSG00000242114,Sub_male,Sub,male,DGE,DGE:DTU,ENSG00000242114,not_gwas
+female:male,ENSG00000242114,MTFP1,ENSG00000242114,aINS_female,aINS,female,DTU,DGE:DTU,ENSG00000242114,not_gwas
+female:male,ENSG00000239887,C1orf226,ENSG00000239887,OFC_male,OFC,male,DTE,DTE:DTU,ENSG00000239887,not_gwas
+female:male,ENSG00000239887,C1orf226,ENSG00000239887,Cg25_female,Cg25,female,DTU,DTE:DTU,ENSG00000239887,not_gwas
+female:male,ENSG00000121039,RDH10,ENSG00000121039,Cg25_male,Cg25,male,DTU,DTU,ENSG00000121039,not_gwas
+female:male,ENSG00000121039,RDH10,ENSG00000121039,dlPFC_female,dlPFC,female,DTU,DTU,ENSG00000121039,not_gwas
+female:male,ENSG00000172889,EGFL7,ENSG00000172889,Cg25_male,Cg25,male,DGE,DGE:DTU,ENSG00000172889,not_gwas
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+female:male,ENSG00000114204,SERPINI2,ENSG00000114204,Cg25_male,Cg25,male,DGE,DGE:DTU,ENSG00000114204,not_gwas
+female:male,ENSG00000114204,SERPINI2,ENSG00000114204,OFC_female,OFC,female,DTU,DGE:DTU,ENSG00000114204,not_gwas
+female:male,ENSG00000154096,THY1,ENSG00000154096,Cg25_male,Cg25,male,DTU,DTU,ENSG00000154096,not_gwas
+female:male,ENSG00000154096,THY1,ENSG00000154096,OFC_female,OFC,female,DTU,DTU,ENSG00000154096,not_gwas
+male,ENSG00000283453,PRIM2BP,ENSG00000283453,Nac_male,Nac,male,DGE,DGE,ENSG00000283453,not_gwas
+male,ENSG00000177051,FBXO46,ENSG00000177051,Nac_male,Nac,male,DGE,DGE,ENSG00000177051,not_gwas
+male,ENSG00000161939,RNASEK-C17orf49,ENSG00000161939,Nac_male,Nac,male,DGE,DGE,ENSG00000161939,not_gwas
+male,ENSG00000172476,RAB40A,ENSG00000172476,Nac_male,Nac,male,DGE,DGE,ENSG00000172476,not_gwas
+male,ENSG00000182601,HS3ST4,ENSG00000182601,Nac_male,Nac,male,DGE,DGE,ENSG00000182601,not_gwas
+male,ENSG00000277075,H2AC8,ENSG00000277075,Nac_male,Nac,male,DGE,DGE,ENSG00000277075,not_gwas
+male,ENSG00000100191,SLC5A4,ENSG00000100191,Nac_male,Nac,male,DGE,DGE,ENSG00000100191,not_gwas
+male,ENSG00000100191,SLC5A4,ENSG00000100191,Cg25_male,Cg25,male,DGE,DGE,ENSG00000100191,not_gwas
+male,ENSG00000198658,ABHD17AP1,ENSG00000198658,Nac_male,Nac,male,DGE,DGE,ENSG00000198658,not_gwas
+male,ENSG00000219814,RPL23AP47,ENSG00000219814,Nac_male,Nac,male,DGE,DGE,ENSG00000219814,not_gwas
+male,ENSG00000183807,FAM162B,ENSG00000183807,Nac_male,Nac,male,DGE,DGE,ENSG00000183807,not_gwas
+male,ENSG00000204287,HLA-DRA,ENSG00000204287,Nac_male,Nac,male,DGE,DGE,ENSG00000204287,not_gwas
+male,ENSG00000135114,OASL,ENSG00000135114,Nac_male,Nac,male,DGE,DGE,ENSG00000135114,not_gwas
+male,ENSG00000184731,FAM110C,ENSG00000184731,Nac_male,Nac,male,DGE,DGE,ENSG00000184731,not_gwas
+male,ENSG00000273802,H2BC8,ENSG00000273802,Nac_male,Nac,male,DGE,DGE,ENSG00000273802,not_gwas
+male,ENSG00000124208,PEDS1-UBE2V1,ENSG00000124208,Nac_male,Nac,male,DGE,DGE,ENSG00000124208,not_gwas
+male,ENSG00000181819,KCTD9P2,ENSG00000181819,Nac_male,Nac,male,DGE,DGE,ENSG00000181819,not_gwas
+male,ENSG00000149532,CPSF7,ENSG00000149532,OFC_male,OFC,male,DGE,DGE,ENSG00000149532,not_gwas
+male,ENSG00000241644,INMT,ENSG00000241644,Cg25_male,Cg25,male,DGE,DGE,ENSG00000241644,not_gwas
+male,ENSG00000285607,FAM90A9,ENSG00000285607,Cg25_male,Cg25,male,DGE,DGE,ENSG00000285607,not_gwas
+male,ENSG00000145779,TNFAIP8,ENSG00000145779,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000145779,not_gwas
+male,ENSG00000145779,TNFAIP8,ENSG00000145779,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000145779,not_gwas
+male,ENSG00000104998,IL27RA,ENSG00000104998,Cg25_male,Cg25,male,DGE,DGE,ENSG00000104998,not_gwas
+male,ENSG00000171792,RHNO1,ENSG00000171792,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000171792,not_gwas
+male,ENSG00000171792,RHNO1,ENSG00000171792,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000171792,not_gwas
+male,ENSG00000099917,MED15,ENSG00000099917,Cg25_male,Cg25,male,DGE,DGE,ENSG00000099917,not_gwas
+male,ENSG00000213569,GTF3C6P2,ENSG00000213569,Cg25_male,Cg25,male,DGE,DGE,ENSG00000213569,not_gwas
+male,ENSG00000113460,BRIX1,ENSG00000113460,Cg25_male,Cg25,male,DGE,DGE,ENSG00000113460,not_gwas
+male,ENSG00000008323,PLEKHG6,ENSG00000008323,Cg25_male,Cg25,male,DGE,DGE,ENSG00000008323,not_gwas
+male,ENSG00000197380,DACT3,ENSG00000197380,Cg25_male,Cg25,male,DGE,DGE,ENSG00000197380,not_gwas
+male,ENSG00000128298,BAIAP2L2,ENSG00000128298,Cg25_male,Cg25,male,DGE,DGE,ENSG00000128298,not_gwas
+male,ENSG00000128000,ZNF780B,ENSG00000128000,Cg25_male,Cg25,male,DGE,DGE,ENSG00000128000,not_gwas
+male,ENSG00000141499,WRAP53,ENSG00000141499,Cg25_male,Cg25,male,DGE,DGE,ENSG00000141499,not_gwas
+male,ENSG00000184524,CEND1,ENSG00000184524,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000184524,not_gwas
+male,ENSG00000184524,CEND1,ENSG00000184524,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000184524,not_gwas
+male,ENSG00000146416,AIG1,ENSG00000146416,Cg25_male,Cg25,male,DGE,DGE:DTE:DTU,ENSG00000146416,not_gwas
+male,ENSG00000146416,AIG1,ENSG00000146416,Cg25_male,Cg25,male,DTE,DGE:DTE:DTU,ENSG00000146416,not_gwas
+male,ENSG00000146416,AIG1,ENSG00000146416,Cg25_male,Cg25,male,DTU,DGE:DTE:DTU,ENSG00000146416,not_gwas
+male,ENSG00000105143,SLC1A6,ENSG00000105143,Cg25_male,Cg25,male,DGE,DGE,ENSG00000105143,not_gwas
+male,ENSG00000149925,ALDOA,ENSG00000149925,Cg25_male,Cg25,male,DGE,DGE,ENSG00000149925,not_gwas
+male,ENSG00000184897,H1-10,ENSG00000184897,Cg25_male,Cg25,male,DGE,DGE,ENSG00000184897,not_gwas
+male,ENSG00000117013,KCNQ4,ENSG00000117013,Cg25_male,Cg25,male,DGE,DGE,ENSG00000117013,not_gwas
+male,ENSG00000123329,ARHGAP9,ENSG00000123329,Cg25_male,Cg25,male,DGE,DGE,ENSG00000123329,not_gwas
+male,ENSG00000197121,PGAP1,ENSG00000197121,Cg25_male,Cg25,male,DGE,DGE,ENSG00000197121,not_gwas
+male,ENSG00000214274,ANG,ENSG00000214274,Cg25_male,Cg25,male,DGE,DGE,ENSG00000214274,not_gwas
+male,ENSG00000230097,ME2P1,ENSG00000230097,Cg25_male,Cg25,male,DGE,DGE,ENSG00000230097,not_gwas
+male,ENSG00000117425,PTCH2,ENSG00000117425,Cg25_male,Cg25,male,DGE,DGE,ENSG00000117425,not_gwas
+male,ENSG00000114544,SLC41A3,ENSG00000114544,Cg25_male,Cg25,male,DGE,DGE,ENSG00000114544,not_gwas
+male,ENSG00000237440,ZNF737,ENSG00000237440,Cg25_male,Cg25,male,DGE,DGE,ENSG00000237440,not_gwas
+male,ENSG00000197566,ZNF624,ENSG00000197566,Cg25_male,Cg25,male,DGE,DGE,ENSG00000197566,not_gwas
+male,ENSG00000083457,ITGAE,ENSG00000083457,Cg25_male,Cg25,male,DGE,DGE,ENSG00000083457,not_gwas
+male,ENSG00000147604,RPL7,ENSG00000147604,Cg25_male,Cg25,male,DGE,DGE,ENSG00000147604,not_gwas
+male,ENSG00000114391,RPL24,ENSG00000114391,Cg25_male,Cg25,male,DGE,DGE,ENSG00000114391,not_gwas
+male,ENSG00000172361,CFAP53,ENSG00000172361,Cg25_male,Cg25,male,DGE,DGE,ENSG00000172361,not_gwas
+male,ENSG00000102804,TSC22D1,ENSG00000102804,Cg25_male,Cg25,male,DGE,DGE,ENSG00000102804,not_gwas
+male,ENSG00000174197,MGA,ENSG00000174197,Cg25_male,Cg25,male,DGE,DGE,ENSG00000174197,not_gwas
+male,ENSG00000197050,ZNF420,ENSG00000197050,Cg25_male,Cg25,male,DGE,DGE,ENSG00000197050,not_gwas
+male,ENSG00000130224,LRCH2,ENSG00000130224,Cg25_male,Cg25,male,DGE,DGE,ENSG00000130224,not_gwas
+male,ENSG00000167674,HDGFL2,ENSG00000167674,Cg25_male,Cg25,male,DGE,DGE:DTU,ENSG00000167674,not_gwas
+male,ENSG00000167674,HDGFL2,ENSG00000167674,Cg25_male,Cg25,male,DTU,DGE:DTU,ENSG00000167674,not_gwas
+male,ENSG00000219507,FTH1P8,ENSG00000219507,Cg25_male,Cg25,male,DGE,DGE,ENSG00000219507,not_gwas
+male,ENSG00000177954,RPS27,ENSG00000177954,Cg25_male,Cg25,male,DGE,DGE,ENSG00000177954,not_gwas
+male,ENSG00000180155,LYNX1,ENSG00000180155,Cg25_male,Cg25,male,DGE,DGE,ENSG00000180155,not_gwas
+male,ENSG00000147654,EBAG9,ENSG00000147654,Cg25_male,Cg25,male,DGE,DGE,ENSG00000147654,not_gwas
+male,ENSG00000198618,PPIAP22,ENSG00000198618,Cg25_male,Cg25,male,DGE,DGE,ENSG00000198618,not_gwas
+male,ENSG00000070423,RNF126,ENSG00000070423,Cg25_male,Cg25,male,DGE,DGE,ENSG00000070423,not_gwas
+male,ENSG00000163141,BNIPL,ENSG00000163141,Cg25_male,Cg25,male,DGE,DGE,ENSG00000163141,not_gwas
+male,ENSG00000133265,HSPBP1,ENSG00000133265,Cg25_male,Cg25,male,DGE,DGE,ENSG00000133265,not_gwas
+male,ENSG00000168453,HR,ENSG00000168453,Cg25_male,Cg25,male,DGE,DGE,ENSG00000168453,not_gwas
+male,ENSG00000205593,DENND6B,ENSG00000205593,Cg25_male,Cg25,male,DGE,DGE,ENSG00000205593,not_gwas
+male,ENSG00000179855,GIPC3,ENSG00000179855,Cg25_male,Cg25,male,DGE,DGE,ENSG00000179855,not_gwas
+male,ENSG00000176222,ZNF404,ENSG00000176222,Cg25_male,Cg25,male,DGE,DGE,ENSG00000176222,not_gwas
+male,ENSG00000132128,LRRC41,ENSG00000132128,Cg25_male,Cg25,male,DGE,DGE,ENSG00000132128,not_gwas
+male,ENSG00000270800,RPS10-NUDT3,ENSG00000270800,Cg25_male,Cg25,male,DGE,DGE,ENSG00000270800,not_gwas
+male,ENSG00000157873,TNFRSF14,ENSG00000157873,Cg25_male,Cg25,male,DGE,DGE,ENSG00000157873,not_gwas
+male,ENSG00000154473,BUB3,ENSG00000154473,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000154473,not_gwas
+male,ENSG00000154473,BUB3,ENSG00000154473,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000154473,not_gwas
+male,ENSG00000138777,PPA2,ENSG00000138777,Cg25_male,Cg25,male,DGE,DGE,ENSG00000138777,not_gwas
+male,ENSG00000198821,CD247,ENSG00000198821,Cg25_male,Cg25,male,DGE,DGE,ENSG00000198821,not_gwas
+male,ENSG00000115548,KDM3A,ENSG00000115548,Cg25_male,Cg25,male,DGE,DGE,ENSG00000115548,not_gwas
+male,ENSG00000112763,BTN2A1,ENSG00000112763,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000112763,not_gwas
+male,ENSG00000112763,BTN2A1,ENSG00000112763,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000112763,not_gwas
+male,ENSG00000184863,RBM33,ENSG00000184863,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000184863,not_gwas
+male,ENSG00000184863,RBM33,ENSG00000184863,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000184863,not_gwas
+male,ENSG00000122691,TWIST1,ENSG00000122691,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000122691,not_gwas
+male,ENSG00000122691,TWIST1,ENSG00000122691,Cg25_male,Cg25,male,DTE,DGE:DTE,ENSG00000122691,not_gwas
+male,ENSG00000275048,BSNDP1,ENSG00000275048,Cg25_male,Cg25,male,DGE,DGE,ENSG00000275048,not_gwas
+male,ENSG00000256310,NDUFA5P6,ENSG00000256310,Cg25_male,Cg25,male,DGE,DGE,ENSG00000256310,not_gwas
+male,ENSG00000197748,CFAP43,ENSG00000197748,Cg25_male,Cg25,male,DGE,DGE,ENSG00000197748,not_gwas
+male,ENSG00000042753,AP2S1,ENSG00000042753,Cg25_male,Cg25,male,DGE,DGE,ENSG00000042753,not_gwas
+male,ENSG00000138688,BLTP1,ENSG00000138688,Cg25_male,Cg25,male,DGE,DGE,ENSG00000138688,gwas
+male,ENSG00000118514,ALDH8A1,ENSG00000118514,Cg25_male,Cg25,male,DGE,DGE,ENSG00000118514,not_gwas
+male,ENSG00000013725,CD6,ENSG00000013725,Cg25_male,Cg25,male,DGE,DGE,ENSG00000013725,not_gwas
+male,ENSG00000168000,BSCL2,ENSG00000168000,Cg25_male,Cg25,male,DGE,DGE,ENSG00000168000,not_gwas
+male,ENSG00000144278,GALNT13,ENSG00000144278,Cg25_male,Cg25,male,DGE,DGE,ENSG00000144278,not_gwas
+male,ENSG00000198794,SCAMP5,ENSG00000198794,Cg25_male,Cg25,male,DGE,DGE,ENSG00000198794,not_gwas
+male,ENSG00000133640,LRRIQ1,ENSG00000133640,Cg25_male,Cg25,male,DGE,DGE,ENSG00000133640,not_gwas
+male,ENSG00000166165,CKB,ENSG00000166165,Cg25_male,Cg25,male,DGE,DGE,ENSG00000166165,not_gwas
+male,ENSG00000214076,CPSF1P1,ENSG00000214076,Cg25_male,Cg25,male,DGE,DGE,ENSG00000214076,not_gwas
+male,ENSG00000214076,CPSF1P1,ENSG00000214076,Sub_male,Sub,male,DGE,DGE,ENSG00000214076,not_gwas
+male,ENSG00000133067,LGR6,ENSG00000133067,Cg25_male,Cg25,male,DGE,DGE,ENSG00000133067,not_gwas
+male,ENSG00000118412,CASP8AP2,ENSG00000118412,Cg25_male,Cg25,male,DGE,DGE,ENSG00000118412,not_gwas
+male,ENSG00000187481,HSD3BP1,ENSG00000187481,Cg25_male,Cg25,male,DGE,DGE,ENSG00000187481,not_gwas
+male,ENSG00000139675,HNRNPA1L2,ENSG00000139675,Cg25_male,Cg25,male,DGE,DGE,ENSG00000139675,not_gwas
+male,ENSG00000215867,KRT18P57,ENSG00000215867,Cg25_male,Cg25,male,DGE,DGE,ENSG00000215867,not_gwas
+male,ENSG00000135315,CEP162,ENSG00000135315,Cg25_male,Cg25,male,DGE,DGE,ENSG00000135315,not_gwas
+male,ENSG00000065243,PKN2,ENSG00000065243,Cg25_male,Cg25,male,DGE,DGE,ENSG00000065243,not_gwas
+male,ENSG00000203855,HSD3BP4,ENSG00000203855,Cg25_male,Cg25,male,DGE,DGE,ENSG00000203855,not_gwas
+male,ENSG00000121989,ACVR2A,ENSG00000121989,Cg25_male,Cg25,male,DGE,DGE,ENSG00000121989,not_gwas
+male,ENSG00000009694,TENM1,ENSG00000009694,Cg25_male,Cg25,male,DGE,DGE,ENSG00000009694,not_gwas
+male,ENSG00000177963,RIC8A,ENSG00000177963,Cg25_male,Cg25,male,DGE,DGE,ENSG00000177963,not_gwas
+male,ENSG00000220563,PKMP3,ENSG00000220563,Cg25_male,Cg25,male,DGE,DGE,ENSG00000220563,not_gwas
+male,ENSG00000179611,DGKZP1,ENSG00000179611,Cg25_male,Cg25,male,DGE,DGE,ENSG00000179611,not_gwas
+male,ENSG00000129317,PUS7L,ENSG00000129317,Cg25_male,Cg25,male,DGE,DGE,ENSG00000129317,not_gwas
+male,ENSG00000186577,SMIM29,ENSG00000186577,Cg25_male,Cg25,male,DGE,DGE,ENSG00000186577,not_gwas
+male,ENSG00000164074,ABHD18,ENSG00000164074,Cg25_male,Cg25,male,DGE,DGE,ENSG00000164074,not_gwas
+male,ENSG00000171944,OR52A5,ENSG00000171944,Cg25_male,Cg25,male,DGE,DGE,ENSG00000171944,not_gwas
+male,ENSG00000006015,REX1BD,ENSG00000006015,Cg25_male,Cg25,male,DGE,DGE:DTE,ENSG00000006015,not_gwas
+male,ENSG00000006015,REX1BD,ENSG00000006015,Nac_male,Nac,male,DTE,DGE:DTE,ENSG00000006015,not_gwas
+male,ENSG00000187416,LHFPL3,ENSG00000187416,Cg25_male,Cg25,male,DGE,DGE,ENSG00000187416,not_gwas
+male,ENSG00000168539,CHRM1,ENSG00000168539,Cg25_male,Cg25,male,DGE,DGE,ENSG00000168539,not_gwas
+male,ENSG00000167578,RAB4B,ENSG00000167578,Cg25_male,Cg25,male,DGE,DGE,ENSG00000167578,not_gwas
+male,ENSG00000075292,ZNF638,ENSG00000075292,Cg25_male,Cg25,male,DGE,DGE,ENSG00000075292,not_gwas
+male,ENSG00000143393,PI4KB,ENSG00000143393,Cg25_male,Cg25,male,DGE,DGE,ENSG00000143393,not_gwas
+male,ENSG00000166575,TMEM135,ENSG00000166575,Cg25_male,Cg25,male,DGE,DGE,ENSG00000166575,not_gwas
+male,ENSG00000235141,COX6CP17,ENSG00000235141,Cg25_male,Cg25,male,DGE,DGE,ENSG00000235141,not_gwas
+male,ENSG00000267508,ZNF285,ENSG00000267508,Cg25_male,Cg25,male,DGE,DGE,ENSG00000267508,not_gwas
+male,ENSG00000172059,KLF11,ENSG00000172059,Cg25_male,Cg25,male,DGE,DGE,ENSG00000172059,not_gwas
+male,ENSG00000149582,TMEM25,ENSG00000149582,Cg25_male,Cg25,male,DGE,DGE,ENSG00000149582,not_gwas
+male,ENSG00000181220,ZNF746,ENSG00000181220,Cg25_male,Cg25,male,DGE,DGE,ENSG00000181220,not_gwas
+male,ENSG00000071889,FAM3A,ENSG00000071889,Cg25_male,Cg25,male,DGE,DGE,ENSG00000071889,not_gwas
+male,ENSG00000136770,DNAJC1,ENSG00000136770,Cg25_male,Cg25,male,DGE,DGE,ENSG00000136770,not_gwas
+male,ENSG00000153487,ING1,ENSG00000153487,Cg25_male,Cg25,male,DGE,DGE,ENSG00000153487,not_gwas
+male,ENSG00000189127,ANKRD34B,ENSG00000189127,Cg25_male,Cg25,male,DGE,DGE,ENSG00000189127,not_gwas
+male,ENSG00000082805,ERC1,ENSG00000082805,Cg25_male,Cg25,male,DGE,DGE,ENSG00000082805,not_gwas
+male,ENSG00000203780,FANK1,ENSG00000203780,Cg25_male,Cg25,male,DGE,DGE,ENSG00000203780,not_gwas
+male,ENSG00000115761,NOL10,ENSG00000115761,Cg25_male,Cg25,male,DGE,DGE,ENSG00000115761,not_gwas
+male,ENSG00000113356,POLR3G,ENSG00000113356,Cg25_male,Cg25,male,DGE,DGE,ENSG00000113356,not_gwas
+male,ENSG00000116663,FBXO6,ENSG00000116663,Cg25_male,Cg25,male,DGE,DGE,ENSG00000116663,not_gwas
+male,ENSG00000196961,AP2A1,ENSG00000196961,Cg25_male,Cg25,male,DGE,DGE,ENSG00000196961,not_gwas
+male,ENSG00000154479,CFAP210,ENSG00000154479,Cg25_male,Cg25,male,DGE,DGE,ENSG00000154479,not_gwas
+male,ENSG00000198478,SH3BGRL2,ENSG00000198478,Cg25_male,Cg25,male,DGE,DGE,ENSG00000198478,not_gwas
+male,ENSG00000236565,HNRNPA3P5,ENSG00000236565,Cg25_male,Cg25,male,DGE,DGE,ENSG00000236565,not_gwas
+male,ENSG00000172171,TEFM,ENSG00000172171,Cg25_male,Cg25,male,DGE,DGE,ENSG00000172171,not_gwas
+male,ENSG00000142186,SCYL1,ENSG00000142186,Cg25_male,Cg25,male,DGE,DGE,ENSG00000142186,not_gwas
+male,ENSG00000127580,WDR24,ENSG00000127580,Cg25_male,Cg25,male,DGE,DGE,ENSG00000127580,not_gwas
+male,ENSG00000215472,RPL17-C18orf32,ENSG00000215472,Cg25_male,Cg25,male,DGE,DGE,ENSG00000215472,not_gwas
+male,ENSG00000141580,WDR45B,ENSG00000141580,Cg25_male,Cg25,male,DGE,DGE,ENSG00000141580,not_gwas
+male,ENSG00000177200,CHD9,ENSG00000177200,Cg25_male,Cg25,male,DGE,DGE,ENSG00000177200,not_gwas
+male,ENSG00000116251,RPL22,ENSG00000116251,Cg25_male,Cg25,male,DGE,DGE,ENSG00000116251,not_gwas
+male,ENSG00000138180,CEP55,ENSG00000138180,Cg25_male,Cg25,male,DGE,DGE,ENSG00000138180,not_gwas
+male,ENSG00000178015,GPR150,ENSG00000178015,Cg25_male,Cg25,male,DGE,DGE,ENSG00000178015,not_gwas
+male,ENSG00000174516,PELI3,ENSG00000174516,Cg25_male,Cg25,male,DGE,DGE,ENSG00000174516,not_gwas
+male,ENSG00000170222,ADPRM,ENSG00000170222,Cg25_male,Cg25,male,DGE,DGE,ENSG00000170222,not_gwas
+male,ENSG00000091831,ESR1,ENSG00000091831,Cg25_male,Cg25,male,DGE,DGE,ENSG00000091831,not_gwas
+male,ENSG00000180777,ANKRD30B,ENSG00000180777,Cg25_male,Cg25,male,DGE,DGE:DTU,ENSG00000180777,not_gwas
+male,ENSG00000180777,ANKRD30B,ENSG00000180777,Cg25_male,Cg25,male,DTU,DGE:DTU,ENSG00000180777,not_gwas
+male,ENSG00000155511,GRIA1,ENSG00000155511,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000155511,not_gwas
+male,ENSG00000155511,GRIA1,ENSG00000155511,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000155511,not_gwas
+male,ENSG00000183665,TRMT12,ENSG00000183665,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000183665,not_gwas
+male,ENSG00000183665,TRMT12,ENSG00000183665,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000183665,not_gwas
+male,ENSG00000053438,NNAT,ENSG00000053438,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000053438,not_gwas
+male,ENSG00000053438,NNAT,ENSG00000053438,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000053438,not_gwas
+male,ENSG00000183287,CCBE1,ENSG00000183287,Sub_male,Sub,male,DGE,DGE,ENSG00000183287,not_gwas
+male,ENSG00000119698,PPP4R4,ENSG00000119698,Sub_male,Sub,male,DGE,DGE,ENSG00000119698,not_gwas
+male,ENSG00000106069,CHN2,ENSG00000106069,Sub_male,Sub,male,DGE,DGE,ENSG00000106069,not_gwas
+male,ENSG00000178163,ZNF518B,ENSG00000178163,Sub_male,Sub,male,DGE,DGE,ENSG00000178163,not_gwas
+male,ENSG00000089847,ANKRD24,ENSG00000089847,Sub_male,Sub,male,DGE,DGE,ENSG00000089847,not_gwas
+male,ENSG00000198046,ZNF667,ENSG00000198046,Sub_male,Sub,male,DGE,DGE,ENSG00000198046,not_gwas
+male,ENSG00000147041,SYTL5,ENSG00000147041,Sub_male,Sub,male,DGE,DGE,ENSG00000147041,not_gwas
+male,ENSG00000220804,LINC01881,ENSG00000220804,Sub_male,Sub,male,DGE,DGE,ENSG00000220804,not_gwas
+male,ENSG00000128573,FOXP2,ENSG00000128573,Sub_male,Sub,male,DGE,DGE,ENSG00000128573,gwas
+male,ENSG00000185052,SLC24A3,ENSG00000185052,Sub_male,Sub,male,DGE,DGE,ENSG00000185052,not_gwas
+male,ENSG00000211896,IGHG1,ENSG00000211896,Sub_male,Sub,male,DGE,DGE,ENSG00000211896,not_gwas
+male,ENSG00000156140,ADAMTS3,ENSG00000156140,Sub_male,Sub,male,DGE,DGE,ENSG00000156140,not_gwas
+male,ENSG00000215388,ACTG1P3,ENSG00000215388,Sub_male,Sub,male,DGE,DGE,ENSG00000215388,not_gwas
+male,ENSG00000146386,ABRACL,ENSG00000146386,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000146386,not_gwas
+male,ENSG00000146386,ABRACL,ENSG00000146386,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000146386,not_gwas
+male,ENSG00000163491,NEK10,ENSG00000163491,Sub_male,Sub,male,DGE,DGE,ENSG00000163491,not_gwas
+male,ENSG00000168538,TRAPPC11,ENSG00000168538,Sub_male,Sub,male,DGE,DGE,ENSG00000168538,not_gwas
+male,ENSG00000105518,TMEM205,ENSG00000105518,Sub_male,Sub,male,DGE,DGE,ENSG00000105518,not_gwas
+male,ENSG00000114654,EFCC1,ENSG00000114654,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000114654,not_gwas
+male,ENSG00000114654,EFCC1,ENSG00000114654,Nac_male,Nac,male,DTE,DGE:DTE,ENSG00000114654,not_gwas
+male,ENSG00000109689,STIM2,ENSG00000109689,Sub_male,Sub,male,DGE,DGE,ENSG00000109689,not_gwas
+male,ENSG00000068366,ACSL4,ENSG00000068366,Sub_male,Sub,male,DGE,DGE,ENSG00000068366,not_gwas
+male,ENSG00000162066,AMDHD2,ENSG00000162066,Sub_male,Sub,male,DGE,DGE,ENSG00000162066,not_gwas
+male,ENSG00000028839,TBPL1,ENSG00000028839,Sub_male,Sub,male,DGE,DGE,ENSG00000028839,not_gwas
+male,ENSG00000263142,LRRC37A17P,ENSG00000263142,Sub_male,Sub,male,DGE,DGE,ENSG00000263142,not_gwas
+male,ENSG00000119401,TRIM32,ENSG00000119401,Sub_male,Sub,male,DGE,DGE,ENSG00000119401,not_gwas
+male,ENSG00000147400,CETN2,ENSG00000147400,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000147400,not_gwas
+male,ENSG00000147400,CETN2,ENSG00000147400,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000147400,not_gwas
+male,ENSG00000181467,RAP2B,ENSG00000181467,Sub_male,Sub,male,DGE,DGE,ENSG00000181467,not_gwas
+male,ENSG00000151490,PTPRO,ENSG00000151490,Sub_male,Sub,male,DGE,DGE,ENSG00000151490,not_gwas
+male,ENSG00000162437,RAVER2,ENSG00000162437,Sub_male,Sub,male,DGE,DGE,ENSG00000162437,not_gwas
+male,ENSG00000103047,TANGO6,ENSG00000103047,Sub_male,Sub,male,DGE,DGE,ENSG00000103047,not_gwas
+male,ENSG00000130347,RTN4IP1,ENSG00000130347,Sub_male,Sub,male,DGE,DGE,ENSG00000130347,not_gwas
+male,ENSG00000159685,CHCHD6,ENSG00000159685,Sub_male,Sub,male,DGE,DGE,ENSG00000159685,not_gwas
+male,ENSG00000136986,DERL1,ENSG00000136986,Sub_male,Sub,male,DGE,DGE,ENSG00000136986,not_gwas
+male,ENSG00000109466,KLHL2,ENSG00000109466,Sub_male,Sub,male,DGE,DGE,ENSG00000109466,not_gwas
+male,ENSG00000175182,FAM131A,ENSG00000175182,Sub_male,Sub,male,DGE,DGE,ENSG00000175182,not_gwas
+male,ENSG00000059758,CDK17,ENSG00000059758,Sub_male,Sub,male,DGE,DGE,ENSG00000059758,not_gwas
+male,ENSG00000140623,SEPTIN12,ENSG00000140623,Sub_male,Sub,male,DGE,DGE,ENSG00000140623,not_gwas
+male,ENSG00000184307,ZDHHC23,ENSG00000184307,Sub_male,Sub,male,DGE,DGE,ENSG00000184307,not_gwas
+male,ENSG00000154654,NCAM2,ENSG00000154654,Sub_male,Sub,male,DGE,DGE,ENSG00000154654,not_gwas
+male,ENSG00000115091,ACTR3,ENSG00000115091,Sub_male,Sub,male,DGE,DGE,ENSG00000115091,not_gwas
+male,ENSG00000163468,CCT3,ENSG00000163468,Sub_male,Sub,male,DGE,DGE,ENSG00000163468,not_gwas
+male,ENSG00000008083,JARID2,ENSG00000008083,Sub_male,Sub,male,DGE,DGE,ENSG00000008083,not_gwas
+male,ENSG00000164603,BMT2,ENSG00000164603,Sub_male,Sub,male,DGE,DGE,ENSG00000164603,not_gwas
+male,ENSG00000117069,ST6GALNAC5,ENSG00000117069,Sub_male,Sub,male,DGE,DGE,ENSG00000117069,not_gwas
+male,ENSG00000239649,MYADML,ENSG00000239649,Sub_male,Sub,male,DGE,DGE,ENSG00000239649,not_gwas
+male,ENSG00000156414,TDRD9,ENSG00000156414,Sub_male,Sub,male,DGE,DGE,ENSG00000156414,not_gwas
+male,ENSG00000102078,SLC25A14,ENSG00000102078,Sub_male,Sub,male,DGE,DGE,ENSG00000102078,not_gwas
+male,ENSG00000156261,CCT8,ENSG00000156261,Sub_male,Sub,male,DGE,DGE,ENSG00000156261,not_gwas
+male,ENSG00000174684,B4GAT1,ENSG00000174684,Sub_male,Sub,male,DGE,DGE,ENSG00000174684,not_gwas
+male,ENSG00000271207,MTCO1P22,ENSG00000271207,Sub_male,Sub,male,DGE,DGE,ENSG00000271207,not_gwas
+male,ENSG00000131747,TOP2A,ENSG00000131747,Sub_male,Sub,male,DGE,DGE,ENSG00000131747,not_gwas
+male,ENSG00000219294,PIP5K1P1,ENSG00000219294,Sub_male,Sub,male,DGE,DGE,ENSG00000219294,not_gwas
+male,ENSG00000198185,ZNF334,ENSG00000198185,Sub_male,Sub,male,DGE,DGE,ENSG00000198185,not_gwas
+male,ENSG00000071127,WDR1,ENSG00000071127,Sub_male,Sub,male,DGE,DGE,ENSG00000071127,not_gwas
+male,ENSG00000197859,ADAMTSL2,ENSG00000197859,Sub_male,Sub,male,DGE,DGE,ENSG00000197859,not_gwas
+male,ENSG00000105173,CCNE1,ENSG00000105173,Sub_male,Sub,male,DGE,DGE,ENSG00000105173,not_gwas
+male,ENSG00000250982,GAPDHP35,ENSG00000250982,Sub_male,Sub,male,DGE,DGE,ENSG00000250982,not_gwas
+male,ENSG00000011009,LYPLA2,ENSG00000011009,Sub_male,Sub,male,DGE,DGE,ENSG00000011009,not_gwas
+male,ENSG00000047249,ATP6V1H,ENSG00000047249,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000047249,not_gwas
+male,ENSG00000047249,ATP6V1H,ENSG00000047249,Sub_male,Sub,male,DTE,DGE:DTE,ENSG00000047249,not_gwas
+male,ENSG00000121073,SLC35B1,ENSG00000121073,Sub_male,Sub,male,DGE,DGE,ENSG00000121073,not_gwas
+male,ENSG00000157211,CDCP2,ENSG00000157211,Sub_male,Sub,male,DGE,DGE,ENSG00000157211,not_gwas
+male,ENSG00000102753,KPNA3,ENSG00000102753,Sub_male,Sub,male,DGE,DGE,ENSG00000102753,not_gwas
+male,ENSG00000170881,RNF139,ENSG00000170881,Sub_male,Sub,male,DGE,DGE,ENSG00000170881,not_gwas
+male,ENSG00000117477,CCDC181,ENSG00000117477,Sub_male,Sub,male,DGE,DGE,ENSG00000117477,not_gwas
+male,ENSG00000229184,ATP5PDP2,ENSG00000229184,Sub_male,Sub,male,DGE,DGE,ENSG00000229184,not_gwas
+male,ENSG00000145050,MANF,ENSG00000145050,Sub_male,Sub,male,DGE,DGE,ENSG00000145050,not_gwas
+male,ENSG00000128595,CALU,ENSG00000128595,Sub_male,Sub,male,DGE,DGE,ENSG00000128595,not_gwas
+male,ENSG00000206145,P2RX6P,ENSG00000206145,Sub_male,Sub,male,DGE,DGE,ENSG00000206145,not_gwas
+male,ENSG00000160087,UBE2J2,ENSG00000160087,Sub_male,Sub,male,DGE,DGE,ENSG00000160087,not_gwas
+male,ENSG00000176956,LY6H,ENSG00000176956,Sub_male,Sub,male,DGE,DGE:DTE,ENSG00000176956,not_gwas
+male,ENSG00000176956,LY6H,ENSG00000176956,aINS_male,aINS,male,DTE,DGE:DTE,ENSG00000176956,not_gwas
+male,ENSG00000169976,SF3B5,ENSG00000169976,Sub_male,Sub,male,DGE,DGE,ENSG00000169976,not_gwas
+male,ENSG00000079689,SCGN,ENSG00000079689,Sub_male,Sub,male,DGE,DGE,ENSG00000079689,not_gwas
+male,ENSG00000242372,EIF6,ENSG00000242372,Sub_male,Sub,male,DGE,DGE,ENSG00000242372,not_gwas
+male,ENSG00000168036,CTNNB1,ENSG00000168036,Sub_male,Sub,male,DGE,DGE,ENSG00000168036,not_gwas
+male,ENSG00000270326,SMIM15P2,ENSG00000270326,Sub_male,Sub,male,DGE,DGE,ENSG00000270326,not_gwas
+male,ENSG00000133872,SARAF,ENSG00000133872,Sub_male,Sub,male,DGE,DGE,ENSG00000133872,not_gwas
+male,ENSG00000108256,NUFIP2,ENSG00000108256,Sub_male,Sub,male,DGE,DGE,ENSG00000108256,not_gwas
+male,ENSG00000164080,RAD54L2,ENSG00000164080,Sub_male,Sub,male,DGE,DGE,ENSG00000164080,not_gwas
+male,ENSG00000259330,INAFM2,ENSG00000259330,Sub_male,Sub,male,DGE,DGE,ENSG00000259330,not_gwas
+male,ENSG00000165905,LARGE2,ENSG00000165905,Sub_male,Sub,male,DGE,DGE,ENSG00000165905,not_gwas
+male,ENSG00000277883,NLRP3P1,ENSG00000277883,Sub_male,Sub,male,DGE,DGE,ENSG00000277883,not_gwas
+male,ENSG00000117543,DPH5,ENSG00000117543,Sub_male,Sub,male,DGE,DGE,ENSG00000117543,not_gwas
+male,ENSG00000185272,RBM11,ENSG00000185272,Sub_male,Sub,male,DGE,DGE,ENSG00000185272,not_gwas
+male,ENSG00000189369,GSPT2,ENSG00000189369,Sub_male,Sub,male,DGE,DGE,ENSG00000189369,not_gwas
+male,ENSG00000114480,GBE1,ENSG00000114480,Sub_male,Sub,male,DGE,DGE,ENSG00000114480,not_gwas
+male,ENSG00000154262,ABCA6,ENSG00000154262,Sub_male,Sub,male,DGE,DGE,ENSG00000154262,not_gwas
+male,ENSG00000160973,FOXH1,ENSG00000160973,Sub_male,Sub,male,DGE,DGE,ENSG00000160973,not_gwas
+male,ENSG00000185187,SIGIRR,ENSG00000185187,Sub_male,Sub,male,DGE,DGE,ENSG00000185187,not_gwas
+male,ENSG00000174567,GOLT1A,ENSG00000174567,Sub_male,Sub,male,DGE,DGE,ENSG00000174567,not_gwas
+male,ENSG00000161960,EIF4A1,ENSG00000161960,Sub_male,Sub,male,DGE,DGE,ENSG00000161960,not_gwas
+male,ENSG00000108641,B9D1,ENSG00000108641,Sub_male,Sub,male,DGE,DGE,ENSG00000108641,not_gwas
+male,ENSG00000065183,WDR3,ENSG00000065183,Sub_male,Sub,male,DGE,DGE,ENSG00000065183,not_gwas
+male,ENSG00000189045,ANKDD1B,ENSG00000189045,Sub_male,Sub,male,DGE,DGE,ENSG00000189045,not_gwas
+male,ENSG00000059769,DNAJC25,ENSG00000059769,Sub_male,Sub,male,DGE,DGE,ENSG00000059769,not_gwas
+male,ENSG00000163630,SYNPR,ENSG00000163630,Sub_male,Sub,male,DGE,DGE,ENSG00000163630,not_gwas
+male,ENSG00000132463,GRSF1,ENSG00000132463,Sub_male,Sub,male,DGE,DGE,ENSG00000132463,not_gwas
+male,ENSG00000116906,GNPAT,ENSG00000116906,Sub_male,Sub,male,DGE,DGE,ENSG00000116906,not_gwas
+male,ENSG00000089169,RPH3A,ENSG00000089169,Sub_male,Sub,male,DGE,DGE,ENSG00000089169,not_gwas
+male,ENSG00000125870,SNRPB2,ENSG00000125870,Sub_male,Sub,male,DGE,DGE,ENSG00000125870,not_gwas
+male,ENSG00000253729,PRKDC,ENSG00000253729,Sub_male,Sub,male,DGE,DGE,ENSG00000253729,not_gwas
+male,ENSG00000123496,IL13RA2,ENSG00000123496,Sub_male,Sub,male,DGE,DGE,ENSG00000123496,not_gwas
+male,ENSG00000169282,KCNAB1,ENSG00000169282,Sub_male,Sub,male,DGE,DGE,ENSG00000169282,not_gwas
+male,ENSG00000165688,PMPCA,ENSG00000165688,Sub_male,Sub,male,DGE,DGE,ENSG00000165688,not_gwas
+male,ENSG00000166128,RAB8B,ENSG00000166128,Sub_male,Sub,male,DGE,DGE,ENSG00000166128,not_gwas
+male,ENSG00000274286,ADRA2B,ENSG00000274286,Sub_male,Sub,male,DGE,DGE,ENSG00000274286,not_gwas
+male,ENSG00000221968,FADS3,ENSG00000221968,Nac_male,Nac,male,DTE,DTE,ENSG00000221968,not_gwas
+male,ENSG00000144550,CPNE9,ENSG00000144550,Nac_male,Nac,male,DTE,DTE,ENSG00000144550,not_gwas
+male,ENSG00000132386,SERPINF1,ENSG00000132386,Nac_male,Nac,male,DTE,DTE,ENSG00000132386,not_gwas
+male,ENSG00000166257,SCN3B,ENSG00000166257,Nac_male,Nac,male,DTE,DTE,ENSG00000166257,not_gwas
+male,ENSG00000144868,TMEM108,ENSG00000144868,Nac_male,Nac,male,DTE,DTE,ENSG00000144868,not_gwas
+male,ENSG00000103245,CIAO3,ENSG00000103245,Nac_male,Nac,male,DTE,DTE,ENSG00000103245,not_gwas
+male,ENSG00000162601,MYSM1,ENSG00000162601,Nac_male,Nac,male,DTE,DTE,ENSG00000162601,not_gwas
+male,ENSG00000178719,GRINA,ENSG00000178719,Nac_male,Nac,male,DTE,DTE,ENSG00000178719,not_gwas
+male,ENSG00000132640,BTBD3,ENSG00000132640,Nac_male,Nac,male,DTE,DTE,ENSG00000132640,not_gwas
+male,ENSG00000174996,KLC2,ENSG00000174996,Nac_male,Nac,male,DTE,DTE,ENSG00000174996,not_gwas
+male,ENSG00000145715,RASA1,ENSG00000145715,Nac_male,Nac,male,DTE,DTE,ENSG00000145715,not_gwas
+male,ENSG00000006283,CACNA1G,ENSG00000006283,Nac_male,Nac,male,DTE,DTE,ENSG00000006283,not_gwas
+male,ENSG00000105711,SCN1B,ENSG00000105711,Nac_male,Nac,male,DTE,DTE,ENSG00000105711,not_gwas
+male,ENSG00000157214,STEAP2,ENSG00000157214,Nac_male,Nac,male,DTE,DTE,ENSG00000157214,not_gwas
+male,ENSG00000176697,BDNF,ENSG00000176697,Nac_male,Nac,male,DTE,DTE,ENSG00000176697,not_gwas
+male,ENSG00000162300,ZFPL1,ENSG00000162300,Nac_male,Nac,male,DTE,DTE,ENSG00000162300,not_gwas
+male,ENSG00000040608,RTN4R,ENSG00000040608,Nac_male,Nac,male,DTE,DTE,ENSG00000040608,not_gwas
+male,ENSG00000179603,GRM8,ENSG00000179603,Nac_male,Nac,male,DTE,DTE,ENSG00000179603,not_gwas
+male,ENSG00000162520,SYNC,ENSG00000162520,Nac_male,Nac,male,DTE,DTE,ENSG00000162520,not_gwas
+male,ENSG00000073849,ST6GAL1,ENSG00000073849,Nac_male,Nac,male,DTE,DTE,ENSG00000073849,not_gwas
+male,ENSG00000116991,SIPA1L2,ENSG00000116991,Nac_male,Nac,male,DTE,DTE,ENSG00000116991,not_gwas
+male,ENSG00000165804,ZNF219,ENSG00000165804,Nac_male,Nac,male,DTE,DTE,ENSG00000165804,not_gwas
+male,ENSG00000205221,VIT,ENSG00000205221,Nac_male,Nac,male,DTE,DTE,ENSG00000205221,not_gwas
+male,ENSG00000121064,SCPEP1,ENSG00000121064,Nac_male,Nac,male,DTE,DTE,ENSG00000121064,not_gwas
+male,ENSG00000164294,GPX8,ENSG00000164294,Nac_male,Nac,male,DTE,DTE,ENSG00000164294,not_gwas
+male,ENSG00000105204,DYRK1B,ENSG00000105204,Nac_male,Nac,male,DTE,DTE,ENSG00000105204,not_gwas
+male,ENSG00000166558,SLC38A8,ENSG00000166558,Nac_male,Nac,male,DTE,DTE,ENSG00000166558,not_gwas
+male,ENSG00000125656,CLPP,ENSG00000125656,Nac_male,Nac,male,DTE,DTE,ENSG00000125656,not_gwas
+male,ENSG00000176383,B3GNT4,ENSG00000176383,Nac_male,Nac,male,DTE,DTE,ENSG00000176383,not_gwas
+male,ENSG00000106689,LHX2,ENSG00000106689,Nac_male,Nac,male,DTE,DTE,ENSG00000106689,not_gwas
+male,ENSG00000203734,ECT2L,ENSG00000203734,Nac_male,Nac,male,DTE,DTE,ENSG00000203734,not_gwas
+male,ENSG00000153395,LPCAT1,ENSG00000153395,Nac_male,Nac,male,DTE,DTE,ENSG00000153395,not_gwas
+male,ENSG00000108219,TSPAN14,ENSG00000108219,Nac_male,Nac,male,DTE,DTE,ENSG00000108219,not_gwas
+male,ENSG00000143093,STRIP1,ENSG00000143093,Nac_male,Nac,male,DTE,DTE,ENSG00000143093,not_gwas
+male,ENSG00000159110,IFNAR2,ENSG00000159110,Nac_male,Nac,male,DTE,DTE,ENSG00000159110,not_gwas
+male,ENSG00000143740,SNAP47,ENSG00000143740,Nac_male,Nac,male,DTE,DTE,ENSG00000143740,not_gwas
+male,ENSG00000117632,STMN1,ENSG00000117632,Nac_male,Nac,male,DTE,DTE,ENSG00000117632,not_gwas
+male,ENSG00000277161,PIGW,ENSG00000277161,Nac_male,Nac,male,DTE,DTE,ENSG00000277161,not_gwas
+male,ENSG00000104341,LAPTM4B,ENSG00000104341,Nac_male,Nac,male,DTE,DTE,ENSG00000104341,not_gwas
+male,ENSG00000147457,CHMP7,ENSG00000147457,Nac_male,Nac,male,DTE,DTE,ENSG00000147457,not_gwas
+male,ENSG00000148832,PAOX,ENSG00000148832,Nac_male,Nac,male,DTE,DTE,ENSG00000148832,not_gwas
+male,ENSG00000265366,GLUD1P2,ENSG00000265366,Nac_male,Nac,male,DTE,DTE,ENSG00000265366,not_gwas
+male,ENSG00000178404,CEP295NL,ENSG00000178404,Nac_male,Nac,male,DTE,DTE,ENSG00000178404,not_gwas
+male,ENSG00000104976,SNAPC2,ENSG00000104976,Nac_male,Nac,male,DTE,DTE,ENSG00000104976,not_gwas
+male,ENSG00000238227,TMEM250,ENSG00000238227,Nac_male,Nac,male,DTE,DTE,ENSG00000238227,not_gwas
+male,ENSG00000198483,ANKRD35,ENSG00000198483,Nac_male,Nac,male,DTE,DTE,ENSG00000198483,not_gwas
+male,ENSG00000106236,NPTX2,ENSG00000106236,Nac_male,Nac,male,DTE,DTE,ENSG00000106236,not_gwas
+male,ENSG00000143630,HCN3,ENSG00000143630,Nac_male,Nac,male,DTE,DTE,ENSG00000143630,not_gwas
+male,ENSG00000143630,HCN3,ENSG00000143630,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000143630,not_gwas
+male,ENSG00000160949,TONSL,ENSG00000160949,Nac_male,Nac,male,DTE,DTE,ENSG00000160949,not_gwas
+male,ENSG00000101333,PLCB4,ENSG00000101333,Nac_male,Nac,male,DTE,DTE,ENSG00000101333,not_gwas
+male,ENSG00000188878,FBF1,ENSG00000188878,OFC_male,OFC,male,DTE,DTE,ENSG00000188878,not_gwas
+male,ENSG00000217128,FNIP1,ENSG00000217128,OFC_male,OFC,male,DTE,DTE,ENSG00000217128,not_gwas
+male,ENSG00000137411,VARS2,ENSG00000137411,OFC_male,OFC,male,DTE,DTE,ENSG00000137411,not_gwas
+male,ENSG00000163016,ALMS1P1,ENSG00000163016,OFC_male,OFC,male,DTE,DTE,ENSG00000163016,not_gwas
+male,ENSG00000154358,OBSCN,ENSG00000154358,OFC_male,OFC,male,DTE,DTE,ENSG00000154358,not_gwas
+male,ENSG00000188343,CIBAR1,ENSG00000188343,OFC_male,OFC,male,DTE,DTE,ENSG00000188343,not_gwas
+male,ENSG00000117153,KLHL12,ENSG00000117153,OFC_male,OFC,male,DTE,DTE,ENSG00000117153,not_gwas
+male,ENSG00000104883,PEX11G,ENSG00000104883,OFC_male,OFC,male,DTE,DTE:DTU,ENSG00000104883,not_gwas
+male,ENSG00000104883,PEX11G,ENSG00000104883,OFC_male,OFC,male,DTU,DTE:DTU,ENSG00000104883,not_gwas
+male,ENSG00000174292,TNK1,ENSG00000174292,OFC_male,OFC,male,DTE,DTE,ENSG00000174292,not_gwas
+male,ENSG00000159247,TUBBP5,ENSG00000159247,OFC_male,OFC,male,DTE,DTE,ENSG00000159247,not_gwas
+male,ENSG00000185803,SLC52A2,ENSG00000185803,OFC_male,OFC,male,DTE,DTE,ENSG00000185803,not_gwas
+male,ENSG00000140835,CHST4,ENSG00000140835,OFC_male,OFC,male,DTE,DTE,ENSG00000140835,not_gwas
+male,ENSG00000133105,RXFP2,ENSG00000133105,OFC_male,OFC,male,DTE,DTE,ENSG00000133105,not_gwas
+male,ENSG00000133105,RXFP2,ENSG00000133105,aINS_male,aINS,male,DTE,DTE,ENSG00000133105,not_gwas
+male,ENSG00000170579,DLGAP1,ENSG00000170579,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000170579,not_gwas
+male,ENSG00000165874,SHLD2P1,ENSG00000165874,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000165874,not_gwas
+male,ENSG00000173598,NUDT4,ENSG00000173598,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000173598,not_gwas
+male,ENSG00000100138,SNU13,ENSG00000100138,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000100138,not_gwas
+male,ENSG00000141404,GNAL,ENSG00000141404,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000141404,not_gwas
+male,ENSG00000152672,CLEC4F,ENSG00000152672,dlPFC_male,dlPFC,male,DTE,DTE,ENSG00000152672,not_gwas
+male,ENSG00000172969,FRG2C,ENSG00000172969,Cg25_male,Cg25,male,DTE,DTE,ENSG00000172969,not_gwas
+male,ENSG00000070961,ATP2B1,ENSG00000070961,Cg25_male,Cg25,male,DTE,DTE,ENSG00000070961,not_gwas
+male,ENSG00000213047,DENND1B,ENSG00000213047,Cg25_male,Cg25,male,DTE,DTE,ENSG00000213047,gwas
+male,ENSG00000109971,HSPA8,ENSG00000109971,Cg25_male,Cg25,male,DTE,DTE,ENSG00000109971,not_gwas
+male,ENSG00000205609,EIF3CL,ENSG00000205609,Cg25_male,Cg25,male,DTE,DTE,ENSG00000205609,not_gwas
+male,ENSG00000074317,SNCB,ENSG00000074317,Cg25_male,Cg25,male,DTE,DTE,ENSG00000074317,not_gwas
+male,ENSG00000196498,NCOR2,ENSG00000196498,Cg25_male,Cg25,male,DTE,DTE,ENSG00000196498,not_gwas
+male,ENSG00000164483,SAMD3,ENSG00000164483,Cg25_male,Cg25,male,DTE,DTE,ENSG00000164483,not_gwas
+male,ENSG00000172809,RPL38,ENSG00000172809,Cg25_male,Cg25,male,DTE,DTE,ENSG00000172809,not_gwas
+male,ENSG00000076248,UNG,ENSG00000076248,Cg25_male,Cg25,male,DTE,DTE,ENSG00000076248,not_gwas
+male,ENSG00000076248,UNG,ENSG00000076248,Sub_male,Sub,male,DTE,DTE,ENSG00000076248,not_gwas
+male,ENSG00000084207,GSTP1,ENSG00000084207,Cg25_male,Cg25,male,DTE,DTE,ENSG00000084207,not_gwas
+male,ENSG00000152208,GRID2,ENSG00000152208,Cg25_male,Cg25,male,DTE,DTE,ENSG00000152208,not_gwas
+male,ENSG00000153207,AHCTF1,ENSG00000153207,Cg25_male,Cg25,male,DTE,DTE,ENSG00000153207,not_gwas
+male,ENSG00000130204,TOMM40,ENSG00000130204,Cg25_male,Cg25,male,DTE,DTE:DTU,ENSG00000130204,not_gwas
+male,ENSG00000130204,TOMM40,ENSG00000130204,Cg25_male,Cg25,male,DTU,DTE:DTU,ENSG00000130204,not_gwas
+male,ENSG00000135686,KLHL36,ENSG00000135686,Cg25_male,Cg25,male,DTE,DTE,ENSG00000135686,not_gwas
+male,ENSG00000139200,PIANP,ENSG00000139200,Cg25_male,Cg25,male,DTE,DTE,ENSG00000139200,not_gwas
+male,ENSG00000145826,LECT2,ENSG00000145826,Cg25_male,Cg25,male,DTE,DTE,ENSG00000145826,not_gwas
+male,ENSG00000163596,ICA1L,ENSG00000163596,Cg25_male,Cg25,male,DTE,DTE,ENSG00000163596,not_gwas
+male,ENSG00000242173,ARHGDIG,ENSG00000242173,Cg25_male,Cg25,male,DTE,DTE,ENSG00000242173,not_gwas
+male,ENSG00000124172,ATP5F1E,ENSG00000124172,Cg25_male,Cg25,male,DTE,DTE,ENSG00000124172,not_gwas
+male,ENSG00000186350,RXRA,ENSG00000186350,aINS_male,aINS,male,DTE,DTE,ENSG00000186350,not_gwas
+male,ENSG00000151718,WWC2,ENSG00000151718,aINS_male,aINS,male,DTE,DTE,ENSG00000151718,not_gwas
+male,ENSG00000008382,MPND,ENSG00000008382,aINS_male,aINS,male,DTE,DTE,ENSG00000008382,not_gwas
+male,ENSG00000157557,ETS2,ENSG00000157557,aINS_male,aINS,male,DTE,DTE,ENSG00000157557,not_gwas
+male,ENSG00000099364,FBXL19,ENSG00000099364,aINS_male,aINS,male,DTE,DTE,ENSG00000099364,not_gwas
+male,ENSG00000090097,PCBP4,ENSG00000090097,Sub_male,Sub,male,DTE,DTE,ENSG00000090097,not_gwas
+male,ENSG00000145526,CDH18,ENSG00000145526,Sub_male,Sub,male,DTE,DTE,ENSG00000145526,not_gwas
+male,ENSG00000141013,GAS8,ENSG00000141013,Sub_male,Sub,male,DTE,DTE,ENSG00000141013,not_gwas
+male,ENSG00000221882,OR3A2,ENSG00000221882,Sub_male,Sub,male,DTE,DTE,ENSG00000221882,not_gwas
+male,ENSG00000143156,NME7,ENSG00000143156,Sub_male,Sub,male,DTE,DTE,ENSG00000143156,not_gwas
+male,ENSG00000164099,PRSS12,ENSG00000164099,Sub_male,Sub,male,DTE,DTE,ENSG00000164099,not_gwas
+male,ENSG00000120500,ARR3,ENSG00000120500,Sub_male,Sub,male,DTE,DTE,ENSG00000120500,not_gwas
+male,ENSG00000057294,PKP2,ENSG00000057294,Sub_male,Sub,male,DTE,DTE,ENSG00000057294,not_gwas
+male,ENSG00000144668,ITGA9,ENSG00000144668,Sub_male,Sub,male,DTE,DTE,ENSG00000144668,not_gwas
+male,ENSG00000186204,CYP4F12,ENSG00000186204,Sub_male,Sub,male,DTE,DTE,ENSG00000186204,not_gwas
+male,ENSG00000115649,CNPPD1,ENSG00000115649,Sub_male,Sub,male,DTE,DTE,ENSG00000115649,not_gwas
+male,ENSG00000184009,ACTG1,ENSG00000184009,Cg25_male,Cg25,male,DTU,DTU,ENSG00000184009,not_gwas
+male,ENSG00000140873,ADAMTS18,ENSG00000140873,Cg25_male,Cg25,male,DTU,DTU,ENSG00000140873,not_gwas
+male,ENSG00000173567,ADGRF3,ENSG00000173567,Cg25_male,Cg25,male,DTU,DTU,ENSG00000173567,not_gwas
+male,ENSG00000112414,ADGRG6,ENSG00000112414,Cg25_male,Cg25,male,DTU,DTU,ENSG00000112414,not_gwas
+male,ENSG00000162618,ADGRL4,ENSG00000162618,Cg25_male,Cg25,male,DTU,DTU,ENSG00000162618,not_gwas
+male,ENSG00000106624,AEBP1,ENSG00000106624,Cg25_male,Cg25,male,DTU,DTU,ENSG00000106624,not_gwas
+male,ENSG00000057663,ATG5,ENSG00000057663,Cg25_male,Cg25,male,DTU,DTU,ENSG00000057663,not_gwas
+male,ENSG00000139044,B4GALNT3,ENSG00000139044,Cg25_male,Cg25,male,DTU,DTU,ENSG00000139044,not_gwas
+male,ENSG00000152611,CAPSL,ENSG00000152611,Cg25_male,Cg25,male,DTU,DTU,ENSG00000152611,not_gwas
+male,ENSG00000291173,CASP17P,ENSG00000291173,Cg25_male,Cg25,male,DTU,DTU,ENSG00000291173,not_gwas
+male,ENSG00000141570,CBX8,ENSG00000141570,Cg25_male,Cg25,male,DTU,DTU,ENSG00000141570,not_gwas
+male,ENSG00000134057,CCNB1,ENSG00000134057,Cg25_male,Cg25,male,DTU,DTU,ENSG00000134057,not_gwas
+male,ENSG00000107443,CCNJ,ENSG00000107443,Cg25_male,Cg25,male,DTU,DTU,ENSG00000107443,not_gwas
+male,ENSG00000116815,CD58,ENSG00000116815,Cg25_male,Cg25,male,DTU,DTU,ENSG00000116815,not_gwas
+male,ENSG00000166091,CMTM5,ENSG00000166091,Cg25_male,Cg25,male,DTU,DTU,ENSG00000166091,not_gwas
+male,ENSG00000102879,CORO1A,ENSG00000102879,Cg25_male,Cg25,male,DTU,DTU,ENSG00000102879,not_gwas
+male,ENSG00000116133,DHCR24,ENSG00000116133,Cg25_male,Cg25,male,DTU,DTU,ENSG00000116133,not_gwas
+male,ENSG00000134516,DOCK2,ENSG00000134516,Cg25_male,Cg25,male,DTU,DTU,ENSG00000134516,not_gwas
+male,ENSG00000100129,EIF3L,ENSG00000100129,Cg25_male,Cg25,male,DTU,DTU,ENSG00000100129,not_gwas
+male,ENSG00000240445,FOXO3B,ENSG00000240445,Cg25_male,Cg25,male,DTU,DTU,ENSG00000240445,not_gwas
+male,ENSG00000105255,FSD1,ENSG00000105255,Cg25_male,Cg25,male,DTU,DTU,ENSG00000105255,not_gwas
+male,ENSG00000226124,FTCDNL1,ENSG00000226124,Cg25_male,Cg25,male,DTU,DTU,ENSG00000226124,not_gwas
+male,ENSG00000144591,GMPPA,ENSG00000144591,Cg25_male,Cg25,male,DTU,DTU,ENSG00000144591,not_gwas
+male,ENSG00000102241,HTATSF1,ENSG00000102241,Cg25_male,Cg25,male,DTU,DTU,ENSG00000102241,not_gwas
+male,ENSG00000110324,IL10RA,ENSG00000110324,Cg25_male,Cg25,male,DTU,DTU,ENSG00000110324,not_gwas
+male,ENSG00000148943,LIN7C,ENSG00000148943,Cg25_male,Cg25,male,DTU,DTU,ENSG00000148943,not_gwas
+male,ENSG00000146006,LRRTM2,ENSG00000146006,Cg25_male,Cg25,male,DTU,DTU,ENSG00000146006,not_gwas
+male,ENSG00000168067,MAP4K2,ENSG00000168067,Cg25_male,Cg25,male,DTU,DTU,ENSG00000168067,not_gwas
+male,ENSG00000090971,"NAT14",ENSG00000090971,Cg25_male,Cg25,male,DTU,DTU,ENSG00000090971,not_gwas
+male,ENSG00000178685,PARP10,ENSG00000178685,Cg25_male,Cg25,male,DTU,DTU,ENSG00000178685,not_gwas
+male,ENSG00000174827,PDZK1,ENSG00000174827,Cg25_male,Cg25,male,DTU,DTU,ENSG00000174827,not_gwas
+male,ENSG00000183571,PGPEP1L,ENSG00000183571,Cg25_male,Cg25,male,DTU,DTU,ENSG00000183571,not_gwas
+male,ENSG00000166428,PLD4,ENSG00000166428,Cg25_male,Cg25,male,DTU,DTU,ENSG00000166428,not_gwas
+male,ENSG00000163932,PRKCD,ENSG00000163932,Cg25_male,Cg25,male,DTU,DTU,ENSG00000163932,not_gwas
+male,ENSG00000204628,RACK1,ENSG00000204628,Cg25_male,Cg25,male,DTU,DTU,ENSG00000204628,not_gwas
+male,ENSG00000117602,RCAN3,ENSG00000117602,Cg25_male,Cg25,male,DTU,DTU,ENSG00000117602,not_gwas
+male,ENSG00000137275,RIPK1,ENSG00000137275,Cg25_male,Cg25,male,DTU,DTU,ENSG00000137275,not_gwas
+male,ENSG00000164610,RP9,ENSG00000164610,Cg25_male,Cg25,male,DTU,DTU,ENSG00000164610,not_gwas
+male,ENSG00000149273,RPS3,ENSG00000149273,Cg25_male,Cg25,male,DTU,DTU,ENSG00000149273,not_gwas
+male,ENSG00000063015,SEZ6,ENSG00000063015,Cg25_male,Cg25,male,DTU,DTU,ENSG00000063015,not_gwas
+male,ENSG00000167447,SMG8,ENSG00000167447,Cg25_male,Cg25,male,DTU,DTU,ENSG00000167447,not_gwas
+male,ENSG00000250317,SMIM20,ENSG00000250317,Cg25_male,Cg25,male,DTU,DTU,ENSG00000250317,not_gwas
+male,ENSG00000077312,SNRPA,ENSG00000077312,Cg25_male,Cg25,male,DTU,DTU,ENSG00000077312,not_gwas
+male,ENSG00000162236,STX5,ENSG00000162236,Cg25_male,Cg25,male,DTU,DTU,ENSG00000162236,not_gwas
+male,ENSG00000132604,TERF2,ENSG00000132604,Cg25_male,Cg25,male,DTU,DTU,ENSG00000132604,not_gwas
+male,ENSG00000145107,TM4SF19,ENSG00000145107,Cg25_male,Cg25,male,DTU,DTU,ENSG00000145107,not_gwas
+male,ENSG00000118271,TTR,ENSG00000118271,Cg25_male,Cg25,male,DTU,DTU,ENSG00000118271,not_gwas
+male,ENSG00000140367,UBE2Q2,ENSG00000140367,Cg25_male,Cg25,male,DTU,DTU,ENSG00000140367,not_gwas
+male,ENSG00000167671,UBXN6,ENSG00000167671,Cg25_male,Cg25,male,DTU,DTU,ENSG00000167671,not_gwas
+male,ENSG00000111186,WNT5B,ENSG00000111186,Cg25_male,Cg25,male,DTU,DTU,ENSG00000111186,not_gwas
+male,ENSG00000198538,ZNF28,ENSG00000198538,Cg25_male,Cg25,male,DTU,DTU,ENSG00000198538,not_gwas
+male,ENSG00000167772,ANGPTL4,ENSG00000167772,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000167772,not_gwas
+male,ENSG00000185689,C6orf201,ENSG00000185689,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000185689,not_gwas
+male,ENSG00000147437,GNRH1,ENSG00000147437,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000147437,not_gwas
+male,ENSG00000116962,NID1,ENSG00000116962,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000116962,not_gwas
+male,ENSG00000163710,PCOLCE2,ENSG00000163710,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000163710,not_gwas
+male,ENSG00000056487,PHF21B,ENSG00000056487,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000056487,not_gwas
+male,ENSG00000174136,RGMB,ENSG00000174136,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000174136,not_gwas
+male,ENSG00000167550,RHEBL1,ENSG00000167550,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000167550,not_gwas
+male,ENSG00000116649,SRM,ENSG00000116649,dlPFC_male,dlPFC,male,DTU,DTU,ENSG00000116649,not_gwas
+male,ENSG00000248477,AC139495,ENSG00000248477,Nac_male,Nac,male,DTU,DTU,ENSG00000248477,not_gwas
+male,ENSG00000250687,AC146944,ENSG00000250687,Nac_male,Nac,male,DTU,DTU,ENSG00000250687,not_gwas
+male,ENSG00000008300,CELSR3,ENSG00000008300,Nac_male,Nac,male,DTU,DTU,ENSG00000008300,not_gwas
+male,ENSG00000185885,IFITM1,ENSG00000185885,Nac_male,Nac,male,DTU,DTU,ENSG00000185885,not_gwas
+male,ENSG00000073150,PANX2,ENSG00000073150,Nac_male,Nac,male,DTU,DTU,ENSG00000073150,not_gwas
+male,ENSG00000225973,PIGBOS1,ENSG00000225973,Nac_male,Nac,male,DTU,DTU,ENSG00000225973,not_gwas
+male,ENSG00000061492,WNT8A,ENSG00000061492,Nac_male,Nac,male,DTU,DTU,ENSG00000061492,not_gwas
+male,ENSG00000100601,ALKBH1,ENSG00000100601,OFC_male,OFC,male,DTU,DTU,ENSG00000100601,not_gwas
+male,ENSG00000215217,C5orf49,ENSG00000215217,OFC_male,OFC,male,DTU,DTU,ENSG00000215217,not_gwas
+male,ENSG00000103326,CAPN15,ENSG00000103326,OFC_male,OFC,male,DTU,DTU,ENSG00000103326,not_gwas
+male,ENSG00000105479,CCDC114,ENSG00000105479,OFC_male,OFC,male,DTU,DTU,ENSG00000105479,not_gwas
+male,ENSG00000248698,LINC01085,ENSG00000248698,OFC_male,OFC,male,DTU,DTU,ENSG00000248698,not_gwas
+male,ENSG00000125841,NRSN2,ENSG00000125841,OFC_male,OFC,male,DTU,DTU,ENSG00000125841,not_gwas
+male,ENSG00000100300,TSPO,ENSG00000100300,OFC_male,OFC,male,DTU,DTU,ENSG00000100300,not_gwas
+male,ENSG00000160685,ZBTB7B,ENSG00000160685,OFC_male,OFC,male,DTU,DTU,ENSG00000160685,not_gwas
+male,ENSG00000184887,BTBD6,ENSG00000184887,Sub_male,Sub,male,DTU,DTU,ENSG00000184887,not_gwas
+male,ENSG00000177627,C12orf54,ENSG00000177627,Sub_male,Sub,male,DTU,DTU,ENSG00000177627,not_gwas
+male,ENSG00000221986,MYBPHL,ENSG00000221986,Sub_male,Sub,male,DTU,DTU,ENSG00000221986,not_gwas
+male,ENSG00000205220,PSMB10,ENSG00000205220,Sub_male,Sub,male,DTU,DTU,ENSG00000205220,not_gwas
+male,ENSG00000165480,SKA3,ENSG00000165480,Sub_male,Sub,male,DTU,DTU,ENSG00000165480,not_gwas
+male,ENSG00000095970,TREM2,ENSG00000095970,Sub_male,Sub,male,DTU,DTU,ENSG00000095970,not_gwas
+male,ENSG00000170703,TTLL6,ENSG00000170703,Sub_male,Sub,male,DTU,DTU,ENSG00000170703,not_gwas
+female,ENSG00000197057,DTHD1,ENSG00000197057,Nac_female,Nac,female,DGE,DGE,ENSG00000197057,not_gwas
+female,ENSG00000179813,FAM216B,ENSG00000179813,Nac_female,Nac,female,DGE,DGE,ENSG00000179813,not_gwas
+female,ENSG00000213085,CFAP45,ENSG00000213085,Nac_female,Nac,female,DGE,DGE,ENSG00000213085,not_gwas
+female,ENSG00000268500,SIGLEC5,ENSG00000268500,Nac_female,Nac,female,DGE,DGE,ENSG00000268500,not_gwas
+female,ENSG00000089041,P2RX7,ENSG00000089041,Nac_female,Nac,female,DGE,DGE,ENSG00000089041,not_gwas
+female,ENSG00000170160,CCDC144A,ENSG00000170160,Nac_female,Nac,female,DGE,DGE,ENSG00000170160,not_gwas
+female,ENSG00000197171,LINC03003,ENSG00000197171,Nac_female,Nac,female,DGE,DGE,ENSG00000197171,not_gwas
+female,ENSG00000188933,USP32P1,ENSG00000188933,Nac_female,Nac,female,DGE,DGE,ENSG00000188933,not_gwas
+female,ENSG00000077327,SPAG6,ENSG00000077327,Nac_female,Nac,female,DGE,DGE,ENSG00000077327,not_gwas
+female,ENSG00000118492,ADGB,ENSG00000118492,Nac_female,Nac,female,DGE,DGE,ENSG00000118492,not_gwas
+female,ENSG00000112761,CCN6,ENSG00000112761,Nac_female,Nac,female,DGE,DGE,ENSG00000112761,not_gwas
+female,ENSG00000166387,PPFIBP2,ENSG00000166387,Nac_female,Nac,female,DGE,DGE,ENSG00000166387,not_gwas
+female,ENSG00000155287,SLC25A28,ENSG00000155287,Nac_female,Nac,female,DGE,DGE,ENSG00000155287,not_gwas
+female,ENSG00000183458,PKD1P3,ENSG00000183458,Nac_female,Nac,female,DGE,DGE,ENSG00000183458,not_gwas
+female,ENSG00000197177,ADGRA1,ENSG00000197177,Nac_female,Nac,female,DGE,DGE:DTE,ENSG00000197177,not_gwas
+female,ENSG00000197177,ADGRA1,ENSG00000197177,Nac_female,Nac,female,DTE,DGE:DTE,ENSG00000197177,not_gwas
+female,ENSG00000131002,TXLNGY,ENSG00000131002,Nac_female,Nac,female,DGE,DGE,ENSG00000131002,not_gwas
+female,ENSG00000169258,GPRIN1,ENSG00000169258,Nac_female,Nac,female,DGE,DGE,ENSG00000169258,not_gwas
+female,ENSG00000100625,SIX4,ENSG00000100625,Nac_female,Nac,female,DGE,DGE,ENSG00000100625,not_gwas
+female,ENSG00000114784,EIF1B,ENSG00000114784,Nac_female,Nac,female,DGE,DGE,ENSG00000114784,not_gwas
+female,ENSG00000162643,DNAI3,ENSG00000162643,Nac_female,Nac,female,DGE,DGE,ENSG00000162643,not_gwas
+female,ENSG00000241343,RPL36A,ENSG00000241343,OFC_female,OFC,female,DGE,DGE,ENSG00000241343,not_gwas
+female,ENSG00000122566,HNRNPA2B1,ENSG00000122566,OFC_female,OFC,female,DGE,DGE,ENSG00000122566,not_gwas
+female,ENSG00000089335,ZNF302,ENSG00000089335,OFC_female,OFC,female,DGE,DGE,ENSG00000089335,not_gwas
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+female,ENSG00000235674,LDHAP2,ENSG00000235674,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000235674,not_gwas
+female,ENSG00000258890,CEP95,ENSG00000258890,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000258890,not_gwas
+female,ENSG00000177984,LCN15,ENSG00000177984,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000177984,not_gwas
+female,ENSG00000241697,TMEFF1,ENSG00000241697,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000241697,not_gwas
+female,ENSG00000237406,NDUFA9P1,ENSG00000237406,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000237406,not_gwas
+female,ENSG00000105404,RABAC1,ENSG00000105404,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000105404,not_gwas
+female,ENSG00000167202,TBC1D2B,ENSG00000167202,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000167202,not_gwas
+female,ENSG00000218186,KRT8P43,ENSG00000218186,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000218186,not_gwas
+female,ENSG00000168096,ANKS3,ENSG00000168096,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000168096,not_gwas
+female,ENSG00000109084,TMEM97,ENSG00000109084,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000109084,not_gwas
+female,ENSG00000143344,RGL1,ENSG00000143344,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000143344,not_gwas
+female,ENSG00000035403,VCL,ENSG00000035403,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000035403,not_gwas
+female,ENSG00000162241,SLC25A45,ENSG00000162241,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000162241,not_gwas
+female,ENSG00000158683,PKD1L1,ENSG00000158683,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000158683,not_gwas
+female,ENSG00000269343,ZNF587B,ENSG00000269343,dlPFC_female,dlPFC,female,DGE,DGE:DTE,ENSG00000269343,not_gwas
+female,ENSG00000269343,ZNF587B,ENSG00000269343,dlPFC_female,dlPFC,female,DTE,DGE:DTE,ENSG00000269343,not_gwas
+female,ENSG00000180708,OR10K2,ENSG00000180708,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000180708,not_gwas
+female,ENSG00000214244,SETP21,ENSG00000214244,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000214244,not_gwas
+female,ENSG00000187391,MAGI2,ENSG00000187391,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000187391,not_gwas
+female,ENSG00000273762,VN1R76P,ENSG00000273762,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000273762,not_gwas
+female,ENSG00000258932,MIR3171HG,ENSG00000258932,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000258932,not_gwas
+female,ENSG00000183604,SMG1P5,ENSG00000183604,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000183604,not_gwas
+female,ENSG00000138472,GUCA1C,ENSG00000138472,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000138472,not_gwas
+female,ENSG00000105186,ANKRD27,ENSG00000105186,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000105186,not_gwas
+female,ENSG00000160117,ANKLE1,ENSG00000160117,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000160117,not_gwas
+female,ENSG00000257966,OLA1P3,ENSG00000257966,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000257966,not_gwas
+female,ENSG00000161642,ZNF385A,ENSG00000161642,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000161642,not_gwas
+female,ENSG00000136542,GALNT5,ENSG00000136542,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000136542,not_gwas
+female,ENSG00000259378,DCAF13P3,ENSG00000259378,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000259378,not_gwas
+female,ENSG00000185031,SLC2A3P2,ENSG00000185031,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000185031,not_gwas
+female,ENSG00000251400,ALDH7A1P1,ENSG00000251400,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000251400,not_gwas
+female,ENSG00000227331,RPL7AP22,ENSG00000227331,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000227331,not_gwas
+female,ENSG00000088356,PDRG1,ENSG00000088356,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000088356,not_gwas
+female,ENSG00000206159,GYG2P1,ENSG00000206159,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000206159,not_gwas
+female,ENSG00000257195,HNRNPA1P50,ENSG00000257195,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000257195,not_gwas
+female,ENSG00000214988,RPL7AP26,ENSG00000214988,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000214988,not_gwas
+female,ENSG00000160049,DFFA,ENSG00000160049,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000160049,not_gwas
+female,ENSG00000139547,RDH16,ENSG00000139547,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000139547,not_gwas
+female,ENSG00000107882,SUFU,ENSG00000107882,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000107882,not_gwas
+female,ENSG00000188001,TPRG1,ENSG00000188001,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000188001,not_gwas
+female,ENSG00000140259,MFAP1,ENSG00000140259,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000140259,not_gwas
+female,ENSG00000127589,TUBBP1,ENSG00000127589,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000127589,not_gwas
+female,ENSG00000243716,NPIPB5,ENSG00000243716,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000243716,not_gwas
+female,ENSG00000232230,TPM4P1,ENSG00000232230,dlPFC_female,dlPFC,female,DGE,DGE,ENSG00000232230,not_gwas
+female,ENSG00000269955,FMC1-LUC7L2,ENSG00000269955,Cg25_female,Cg25,female,DGE,DGE,ENSG00000269955,not_gwas
+female,ENSG00000141569,TRIM65,ENSG00000141569,Cg25_female,Cg25,female,DGE,DGE,ENSG00000141569,not_gwas
+female,ENSG00000238118,SLC25A24P2,ENSG00000238118,Cg25_female,Cg25,female,DGE,DGE,ENSG00000238118,not_gwas
+female,ENSG00000243746,EEF1A1P10,ENSG00000243746,Cg25_female,Cg25,female,DGE,DGE,ENSG00000243746,not_gwas
+female,ENSG00000215812,ZNF847P,ENSG00000215812,Cg25_female,Cg25,female,DGE,DGE,ENSG00000215812,not_gwas
+female,ENSG00000130300,PLVAP,ENSG00000130300,Cg25_female,Cg25,female,DGE,DGE:DTU,ENSG00000130300,not_gwas
+female,ENSG00000130300,PLVAP,ENSG00000130300,Sub_female,Sub,female,DTU,DGE:DTU,ENSG00000130300,not_gwas
+female,ENSG00000109917,ZPR1,ENSG00000109917,Cg25_female,Cg25,female,DGE,DGE,ENSG00000109917,not_gwas
+female,ENSG00000242683,RPL12P21,ENSG00000242683,Cg25_female,Cg25,female,DGE,DGE,ENSG00000242683,not_gwas
+female,ENSG00000163586,FABP1,ENSG00000163586,Cg25_female,Cg25,female,DGE,DGE,ENSG00000163586,not_gwas
+female,ENSG00000127314,RAP1B,ENSG00000127314,aINS_female,aINS,female,DGE,DGE,ENSG00000127314,not_gwas
+female,ENSG00000163872,YEATS2,ENSG00000163872,aINS_female,aINS,female,DGE,DGE,ENSG00000163872,not_gwas
+female,ENSG00000258780,BMS1P15,ENSG00000258780,aINS_female,aINS,female,DGE,DGE,ENSG00000258780,not_gwas
+female,ENSG00000196873,ZNG1C,ENSG00000196873,aINS_female,aINS,female,DGE,DGE,ENSG00000196873,not_gwas
+female,ENSG00000249055,TBCAP3,ENSG00000249055,aINS_female,aINS,female,DGE,DGE,ENSG00000249055,not_gwas
+female,ENSG00000284283,TAF11L4,ENSG00000284283,Sub_female,Sub,female,DGE,DGE,ENSG00000284283,not_gwas
+female,ENSG00000243232,PCDHAC2,ENSG00000243232,Sub_female,Sub,female,DGE,DGE,ENSG00000243232,not_gwas
+female,ENSG00000262583,TMEM231P1,ENSG00000262583,Sub_female,Sub,female,DGE,DGE,ENSG00000262583,not_gwas
+female,ENSG00000152217,SETBP1,ENSG00000152217,Sub_female,Sub,female,DGE,DGE,ENSG00000152217,not_gwas
+female,ENSG00000170956,CEACAM3,ENSG00000170956,Sub_female,Sub,female,DGE,DGE,ENSG00000170956,not_gwas
+female,ENSG00000184349,EFNA5,ENSG00000184349,Sub_female,Sub,female,DGE,DGE,ENSG00000184349,not_gwas
+female,ENSG00000254430,OR6M3P,ENSG00000254430,Sub_female,Sub,female,DGE,DGE,ENSG00000254430,not_gwas
+female,ENSG00000268598,VN1R80P,ENSG00000268598,Sub_female,Sub,female,DGE,DGE,ENSG00000268598,not_gwas
+female,ENSG00000169926,KLF13,ENSG00000169926,Sub_female,Sub,female,DGE,DGE,ENSG00000169926,not_gwas
+female,ENSG00000138463,SLC49A4,ENSG00000138463,Sub_female,Sub,female,DGE,DGE,ENSG00000138463,not_gwas
+female,ENSG00000120549,KIAA1217,ENSG00000120549,Sub_female,Sub,female,DGE,DGE,ENSG00000120549,not_gwas
+female,ENSG00000233609,RPL10P19,ENSG00000233609,Sub_female,Sub,female,DGE,DGE,ENSG00000233609,not_gwas
+female,ENSG00000161835,TAMALIN,ENSG00000161835,Sub_female,Sub,female,DGE,DGE,ENSG00000161835,not_gwas
+female,ENSG00000169727,GPS1,ENSG00000169727,Sub_female,Sub,female,DGE,DGE,ENSG00000169727,not_gwas
+female,ENSG00000055118,KCNH2,ENSG00000055118,Nac_female,Nac,female,DTE,DTE,ENSG00000055118,not_gwas
+female,ENSG00000090238,YPEL3,ENSG00000090238,Nac_female,Nac,female,DTE,DTE,ENSG00000090238,not_gwas
+female,ENSG00000198815,FOXJ3,ENSG00000198815,Nac_female,Nac,female,DTE,DTE,ENSG00000198815,not_gwas
+female,ENSG00000129009,ISLR,ENSG00000129009,Nac_female,Nac,female,DTE,DTE,ENSG00000129009,not_gwas
+female,ENSG00000166448,TMEM130,ENSG00000166448,Nac_female,Nac,female,DTE,DTE,ENSG00000166448,not_gwas
+female,ENSG00000140488,CELF6,ENSG00000140488,Nac_female,Nac,female,DTE,DTE,ENSG00000140488,not_gwas
+female,ENSG00000137343,ATAT1,ENSG00000137343,Nac_female,Nac,female,DTE,DTE,ENSG00000137343,not_gwas
+female,ENSG00000137343,ATAT1,ENSG00000137343,OFC_female,OFC,female,DTE,DTE,ENSG00000137343,not_gwas
+female,ENSG00000137343,ATAT1,ENSG00000137343,dlPFC_female,dlPFC,female,DTE,DTE,ENSG00000137343,not_gwas
+female,ENSG00000151092,NGLY1,ENSG00000151092,Nac_female,Nac,female,DTE,DTE,ENSG00000151092,not_gwas
+female,ENSG00000157103,SLC6A1,ENSG00000157103,Nac_female,Nac,female,DTE,DTE,ENSG00000157103,not_gwas
+female,ENSG00000157103,SLC6A1,ENSG00000157103,OFC_female,OFC,female,DTE,DTE,ENSG00000157103,not_gwas
+female,ENSG00000131323,TRAF3,ENSG00000131323,Nac_female,Nac,female,DTE,DTE,ENSG00000131323,gwas
+female,ENSG00000101945,SUV39H1,ENSG00000101945,Nac_female,Nac,female,DTE,DTE,ENSG00000101945,not_gwas
+female,ENSG00000118689,FOXO3,ENSG00000118689,Nac_female,Nac,female,DTE,DTE,ENSG00000118689,not_gwas
+female,ENSG00000136156,ITM2B,ENSG00000136156,Nac_female,Nac,female,DTE,DTE,ENSG00000136156,not_gwas
+female,ENSG00000150051,MKX,ENSG00000150051,Nac_female,Nac,female,DTE,DTE,ENSG00000150051,not_gwas
+female,ENSG00000114354,TFG,ENSG00000114354,Nac_female,Nac,female,DTE,DTE,ENSG00000114354,not_gwas
+female,ENSG00000138623,SEMA7A,ENSG00000138623,Nac_female,Nac,female,DTE,DTE,ENSG00000138623,not_gwas
+female,ENSG00000105976,MET,ENSG00000105976,Nac_female,Nac,female,DTE,DTE,ENSG00000105976,not_gwas
+female,ENSG00000157502,PWWP3B,ENSG00000157502,Nac_female,Nac,female,DTE,DTE,ENSG00000157502,not_gwas
+female,ENSG00000122034,GTF3A,ENSG00000122034,Nac_female,Nac,female,DTE,DTE,ENSG00000122034,not_gwas
+female,ENSG00000159840,ZYX,ENSG00000159840,Nac_female,Nac,female,DTE,DTE,ENSG00000159840,not_gwas
+female,ENSG00000198133,TMEM229B,ENSG00000198133,Nac_female,Nac,female,DTE,DTE,ENSG00000198133,not_gwas
+female,ENSG00000197826,CFAP299,ENSG00000197826,Nac_female,Nac,female,DTE,DTE,ENSG00000197826,not_gwas
+female,ENSG00000257591,ZNF625,ENSG00000257591,Nac_female,Nac,female,DTE,DTE,ENSG00000257591,not_gwas
+female,ENSG00000144191,CNGA3,ENSG00000144191,Nac_female,Nac,female,DTE,DTE,ENSG00000144191,not_gwas
+female,ENSG00000107404,DVL1,ENSG00000107404,Nac_female,Nac,female,DTE,DTE,ENSG00000107404,not_gwas
+female,ENSG00000166840,GLYATL1,ENSG00000166840,Nac_female,Nac,female,DTE,DTE,ENSG00000166840,not_gwas
+female,ENSG00000165175,MID1IP1,ENSG00000165175,Nac_female,Nac,female,DTE,DTE,ENSG00000165175,not_gwas
+female,ENSG00000170185,USP38,ENSG00000170185,Nac_female,Nac,female,DTE,DTE,ENSG00000170185,not_gwas
+female,ENSG00000137166,FOXP4,ENSG00000137166,Nac_female,Nac,female,DTE,DTE,ENSG00000137166,not_gwas
+female,ENSG00000188042,ARL4C,ENSG00000188042,Nac_female,Nac,female,DTE,DTE,ENSG00000188042,not_gwas
+female,ENSG00000164087,POC1A,ENSG00000164087,Nac_female,Nac,female,DTE,DTE,ENSG00000164087,not_gwas
+female,ENSG00000146469,VIP,ENSG00000146469,Nac_female,Nac,female,DTE,DTE,ENSG00000146469,not_gwas
+female,ENSG00000133639,BTG1,ENSG00000133639,Nac_female,Nac,female,DTE,DTE,ENSG00000133639,not_gwas
+female,ENSG00000163032,VSNL1,ENSG00000163032,Nac_female,Nac,female,DTE,DTE,ENSG00000163032,not_gwas
+female,ENSG00000178602,OTOS,ENSG00000178602,Nac_female,Nac,female,DTE,DTE,ENSG00000178602,not_gwas
+female,ENSG00000078098,FAP,ENSG00000078098,Nac_female,Nac,female,DTE,DTE,ENSG00000078098,not_gwas
+female,ENSG00000110075,PPP6R3,ENSG00000110075,OFC_female,OFC,female,DTE,DTE,ENSG00000110075,not_gwas
+female,ENSG00000100354,TNRC6B,ENSG00000100354,OFC_female,OFC,female,DTE,DTE,ENSG00000100354,not_gwas
+female,ENSG00000127022,CANX,ENSG00000127022,OFC_female,OFC,female,DTE,DTE,ENSG00000127022,not_gwas
+female,ENSG00000180008,SOCS4,ENSG00000180008,OFC_female,OFC,female,DTE,DTE,ENSG00000180008,not_gwas
+female,ENSG00000100650,SRSF5,ENSG00000100650,OFC_female,OFC,female,DTE,DTE,ENSG00000100650,not_gwas
+female,ENSG00000136379,ABHD17C,ENSG00000136379,OFC_female,OFC,female,DTE,DTE,ENSG00000136379,not_gwas
+female,ENSG00000102245,CD40LG,ENSG00000102245,OFC_female,OFC,female,DTE,DTE,ENSG00000102245,not_gwas
+female,ENSG00000104687,GSR,ENSG00000104687,OFC_female,OFC,female,DTE,DTE,ENSG00000104687,not_gwas
+female,ENSG00000148303,RPL7A,ENSG00000148303,OFC_female,OFC,female,DTE,DTE,ENSG00000148303,not_gwas
+female,ENSG00000231584,FAHD2CP,ENSG00000231584,OFC_female,OFC,female,DTE,DTE,ENSG00000231584,not_gwas
+female,ENSG00000178385,PLEKHM3,ENSG00000178385,OFC_female,OFC,female,DTE,DTE,ENSG00000178385,not_gwas
+female,ENSG00000108561,C1QBP,ENSG00000108561,OFC_female,OFC,female,DTE,DTE,ENSG00000108561,not_gwas
+female,ENSG00000184182,UBE2F,ENSG00000184182,OFC_female,OFC,female,DTE,DTE,ENSG00000184182,not_gwas
+female,ENSG00000277149,TYW1B,ENSG00000277149,OFC_female,OFC,female,DTE,DTE,ENSG00000277149,not_gwas
+female,ENSG00000154582,ELOC,ENSG00000154582,OFC_female,OFC,female,DTE,DTE,ENSG00000154582,not_gwas
+female,ENSG00000101473,ACOT8,ENSG00000101473,OFC_female,OFC,female,DTE,DTE,ENSG00000101473,not_gwas
+female,ENSG00000142541,RPL13A,ENSG00000142541,OFC_female,OFC,female,DTE,DTE,ENSG00000142541,not_gwas
+female,ENSG00000118096,IFT46,ENSG00000118096,OFC_female,OFC,female,DTE,DTE,ENSG00000118096,not_gwas
+female,ENSG00000158296,SLC13A3,ENSG00000158296,OFC_female,OFC,female,DTE,DTE,ENSG00000158296,not_gwas
+female,ENSG00000122642,FKBP9,ENSG00000122642,OFC_female,OFC,female,DTE,DTE,ENSG00000122642,not_gwas
+female,ENSG00000158201,ABHD3,ENSG00000158201,OFC_female,OFC,female,DTE,DTE,ENSG00000158201,not_gwas
+female,ENSG00000066027,PPP2R5A,ENSG00000066027,OFC_female,OFC,female,DTE,DTE,ENSG00000066027,not_gwas
+female,ENSG00000179632,MAF1,ENSG00000179632,OFC_female,OFC,female,DTE,DTE,ENSG00000179632,not_gwas
+female,ENSG00000243943,ZNF512,ENSG00000243943,OFC_female,OFC,female,DTE,DTE,ENSG00000243943,not_gwas
+female,ENSG00000172456,FGGY,ENSG00000172456,OFC_female,OFC,female,DTE,DTE,ENSG00000172456,not_gwas
+female,ENSG00000136270,TBRG4,ENSG00000136270,OFC_female,OFC,female,DTE,DTE,ENSG00000136270,not_gwas
+female,ENSG00000136270,TBRG4,ENSG00000136270,Cg25_female,Cg25,female,DTE,DTE,ENSG00000136270,not_gwas
+female,ENSG00000180776,ZDHHC20,ENSG00000180776,OFC_female,OFC,female,DTE,DTE,ENSG00000180776,not_gwas
+female,ENSG00000106615,RHEB,ENSG00000106615,OFC_female,OFC,female,DTE,DTE,ENSG00000106615,not_gwas
+female,ENSG00000100941,PNN,ENSG00000100941,OFC_female,OFC,female,DTE,DTE,ENSG00000100941,not_gwas
+female,ENSG00000155980,KIF5A,ENSG00000155980,OFC_female,OFC,female,DTE,DTE,ENSG00000155980,not_gwas
+female,ENSG00000104904,OAZ1,ENSG00000104904,OFC_female,OFC,female,DTE,DTE,ENSG00000104904,not_gwas
+female,ENSG00000116288,PARK7,ENSG00000116288,OFC_female,OFC,female,DTE,DTE,ENSG00000116288,not_gwas
+female,ENSG00000277053,GTF2IP1,ENSG00000277053,OFC_female,OFC,female,DTE,DTE,ENSG00000277053,not_gwas
+female,ENSG00000072501,SMC1A,ENSG00000072501,OFC_female,OFC,female,DTE,DTE,ENSG00000072501,not_gwas
+female,ENSG00000168291,PDHB,ENSG00000168291,OFC_female,OFC,female,DTE,DTE,ENSG00000168291,not_gwas
+female,ENSG00000159147,DONSON,ENSG00000159147,OFC_female,OFC,female,DTE,DTE,ENSG00000159147,not_gwas
+female,ENSG00000198855,FICD,ENSG00000198855,OFC_female,OFC,female,DTE,DTE,ENSG00000198855,not_gwas
+female,ENSG00000049540,ELN,ENSG00000049540,OFC_female,OFC,female,DTE,DTE,ENSG00000049540,not_gwas
+female,ENSG00000099203,TMED1,ENSG00000099203,OFC_female,OFC,female,DTE,DTE,ENSG00000099203,not_gwas
+female,ENSG00000111011,RSRC2,ENSG00000111011,OFC_female,OFC,female,DTE,DTE,ENSG00000111011,not_gwas
+female,ENSG00000153253,SCN3A,ENSG00000153253,OFC_female,OFC,female,DTE,DTE,ENSG00000153253,not_gwas
+female,ENSG00000149972,CNTN5,ENSG00000149972,OFC_female,OFC,female,DTE,DTE,ENSG00000149972,not_gwas
+female,ENSG00000117118,SDHB,ENSG00000117118,OFC_female,OFC,female,DTE,DTE,ENSG00000117118,not_gwas
+female,ENSG00000109846,CRYAB,ENSG00000109846,OFC_female,OFC,female,DTE,DTE,ENSG00000109846,not_gwas
+female,ENSG00000173812,EIF1,ENSG00000173812,OFC_female,OFC,female,DTE,DTE,ENSG00000173812,not_gwas
+female,ENSG00000111057,KRT18,ENSG00000111057,OFC_female,OFC,female,DTE,DTE,ENSG00000111057,not_gwas
+female,ENSG00000136943,CTSV,ENSG00000136943,OFC_female,OFC,female,DTE,DTE,ENSG00000136943,not_gwas
+female,ENSG00000073921,PICALM,ENSG00000073921,OFC_female,OFC,female,DTE,DTE,ENSG00000073921,not_gwas
+female,ENSG00000100280,AP1B1,ENSG00000100280,OFC_female,OFC,female,DTE,DTE,ENSG00000100280,not_gwas
+female,ENSG00000164535,DAGLB,ENSG00000164535,OFC_female,OFC,female,DTE,DTE,ENSG00000164535,not_gwas
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+female,ENSG00000182872,RBM10,ENSG00000182872,OFC_female,OFC,female,DTU,DTU,ENSG00000182872,not_gwas
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+female,ENSG00000215347,SLC25A5P1,ENSG00000215347,OFC_female,OFC,female,DTU,DTU,ENSG00000215347,not_gwas
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+female,ENSG00000095397,WHRN,ENSG00000095397,OFC_female,OFC,female,DTU,DTU,ENSG00000095397,not_gwas
+female,ENSG00000126215,XRCC3,ENSG00000126215,OFC_female,OFC,female,DTU,DTU,ENSG00000126215,not_gwas
+female,ENSG00000205189,ZBTB10,ENSG00000205189,OFC_female,OFC,female,DTU,DTU,ENSG00000205189,not_gwas
+female,ENSG00000101974,ATP11C,ENSG00000101974,Sub_female,Sub,female,DTU,DTU,ENSG00000101974,not_gwas
+female,ENSG00000103126,AXIN1,ENSG00000103126,Sub_female,Sub,female,DTU,DTU,ENSG00000103126,not_gwas
+female,ENSG00000146540,C7orf50,ENSG00000146540,Sub_female,Sub,female,DTU,DTU,ENSG00000146540,not_gwas
+female,ENSG00000167130,DOLPP1,ENSG00000167130,Sub_female,Sub,female,DTU,DTU,ENSG00000167130,not_gwas
+female,ENSG00000124205,EDN3,ENSG00000124205,Sub_female,Sub,female,DTU,DTU,ENSG00000124205,not_gwas
+female,ENSG00000164404,GDF9,ENSG00000164404,Sub_female,Sub,female,DTU,DTU,ENSG00000164404,not_gwas
+female,ENSG00000176476,SGF29,ENSG00000176476,Sub_female,Sub,female,DTU,DTU,ENSG00000176476,not_gwas
+female,ENSG00000172716,SLFN11,ENSG00000172716,Sub_female,Sub,female,DTU,DTU,ENSG00000172716,not_gwas
diff --git a/results/tables/intersect_by_type_and_gwas.xlsx b/results/tables/intersect_by_type_and_gwas.xlsx
new file mode 100644
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zd~8i8DP(xyw$mYhF5&iK^`#d08VSJ)4!_=+<PKQcav*Itr5#x@o;B6@g4{L7jN25q
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zU|#|LjDdwzQuOgP@u+(V4o%75G+JePe5lAM5(uMZOd5wL+^`Y97A23Icg}LBNO^(C
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literal 0
HcmV?d00001

diff --git a/results/tables/intersect_regions_by_sex_female.csv b/results/tables/intersect_regions_by_sex_female.csv
new file mode 100644
index 0000000..a3830cf
--- /dev/null
+++ b/results/tables/intersect_regions_by_sex_female.csv
@@ -0,0 +1,679 @@
+gene,aINS_female,Cg25_female,dlPFC_female,Nac_female,OFC_female,Sub_female,GENENAME,SYMBOL,exclusive
+ENSG00000198563,1,1,1,0,1,0,DExD-box helicase 39B,DDX39B,4
+ENSG00000137343,0,0,1,1,1,0,alpha tubulin acetyltransferase 1,ATAT1,3
+ENSG00000170144,1,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein A3,HNRNPA3,2
+ENSG00000101972,0,1,0,0,1,0,stromal antigen 2,STAG2,2
+ENSG00000147145,0,1,0,0,1,0,lysophosphatidic acid receptor 4,LPAR4,2
+ENSG00000236523,0,1,0,0,1,0,nucleophosmin 1 pseudogene 40,NPM1P40,2
+ENSG00000118972,0,1,0,0,1,0,fibroblast growth factor 23,FGF23,2
+ENSG00000253488,0,1,0,0,1,0,SINHCAF pseudogene 3,SINHCAFP3,2
+ENSG00000130300,0,1,0,0,0,1,plasmalemma vesicle associated protein,PLVAP,2
+ENSG00000136270,0,1,0,0,1,0,transforming growth factor beta regulator 4,TBRG4,2
+ENSG00000132207,0,1,0,0,1,0,"SLX1 homolog A, structure-specific endonuclease subunit",SLX1A,2
+ENSG00000124191,0,1,0,0,0,1,TOX high mobility group box family member 2,TOX2,2
+ENSG00000144820,0,0,1,0,1,0,adhesion G protein-coupled receptor G7,ADGRG7,2
+ENSG00000187094,0,0,1,0,1,0,cholecystokinin,CCK,2
+ENSG00000157103,0,0,0,1,1,0,solute carrier family 6 member 1,SLC6A1,2
+ENSG00000127314,1,0,0,0,0,0,"RAP1B, member of RAS oncogene family",RAP1B,1
+ENSG00000163872,1,0,0,0,0,0,YEATS domain containing 2,YEATS2,1
+ENSG00000258780,1,0,0,0,0,0,BMS1 pseudogene 15,BMS1P15,1
+ENSG00000196873,1,0,0,0,0,0,COBW domain containing 3,CBWD3,1
+ENSG00000249055,1,0,0,0,0,0,NA,NA,1
+ENSG00000180901,1,0,0,0,0,0,potassium channel tetramerization domain containing 2,KCTD2,1
+ENSG00000205129,1,0,0,0,0,0,chromosome 4 open reading frame 47,C4orf47,1
+ENSG00000099960,1,0,0,0,0,0,solute carrier family 7 member 4,SLC7A4,1
+ENSG00000100350,1,0,0,0,0,0,FAD dependent oxidoreductase domain containing 2,FOXRED2,1
+ENSG00000165675,1,0,0,0,0,0,ecto-NOX disulfide-thiol exchanger 2,ENOX2,1
+ENSG00000077684,1,0,0,0,0,0,jade family PHD finger 1,JADE1,1
+ENSG00000140939,1,0,0,0,0,0,nucleolar protein 3,NOL3,1
+ENSG00000165458,1,0,0,0,0,0,inositol polyphosphate phosphatase like 1,INPPL1,1
+ENSG00000079432,1,0,0,0,0,0,capicua transcriptional repressor,CIC,1
+ENSG00000027075,1,0,0,0,0,0,protein kinase C eta,PRKCH,1
+ENSG00000020181,1,0,0,0,0,0,adhesion G protein-coupled receptor A2,ADGRA2,1
+ENSG00000184110,1,0,0,0,0,0,eukaryotic translation initiation factor 3 subunit C,EIF3C,1
+ENSG00000180537,1,0,0,0,0,0,ring finger protein 182,RNF182,1
+ENSG00000100351,1,0,0,0,0,0,GRB2 related adaptor protein 2,GRAP2,1
+ENSG00000253304,1,0,0,0,0,0,transmembrane protein 200B,TMEM200B,1
+ENSG00000139517,1,0,0,0,0,0,ligand of numb-protein X 2,LNX2,1
+ENSG00000286140,1,0,0,0,0,0,DERPC proline and glycine rich nuclear protein,DERPC,1
+ENSG00000224916,1,0,0,0,0,0,NA,NA,1
+ENSG00000280670,1,0,0,0,0,0,coiled-coil domain containing 163,CCDC163,1
+ENSG00000104894,1,0,0,0,0,0,CD37 molecule,CD37,1
+ENSG00000163793,1,0,0,0,0,0,DnaJ heat shock protein family (Hsp40) member C5 gamma,DNAJC5G,1
+ENSG00000051620,1,0,0,0,0,0,heme binding protein 2,HEBP2,1
+ENSG00000206053,1,0,0,0,0,0,Jupiter microtubule associated homolog 2,JPT2,1
+ENSG00000242114,1,0,0,0,0,0,mitochondrial fission process 1,MTFP1,1
+ENSG00000243678,1,0,0,0,0,0,NME/NM23 nucleoside diphosphate kinase 2,NME2,1
+ENSG00000007062,1,0,0,0,0,0,prominin 1,PROM1,1
+ENSG00000068354,1,0,0,0,0,0,TBC1 domain family member 25,TBC1D25,1
+ENSG00000167619,1,0,0,0,0,0,transmembrane protein 145,TMEM145,1
+ENSG00000185262,1,0,0,0,0,0,UBA like domain containing 2,UBALD2,1
+ENSG00000092470,1,0,0,0,0,0,WD repeat domain 76,WDR76,1
+ENSG00000269955,0,1,0,0,0,0,FMC1-LUC7L2 readthrough,FMC1-LUC7L2,1
+ENSG00000141569,0,1,0,0,0,0,tripartite motif containing 65,TRIM65,1
+ENSG00000238118,0,1,0,0,0,0,SLC25A24 pseudogene 2,SLC25A24P2,1
+ENSG00000243746,0,1,0,0,0,0,eukaryotic translation elongation factor 1 alpha 1 pseudogene 10,EEF1A1P10,1
+ENSG00000215812,0,1,0,0,0,0,NA,NA,1
+ENSG00000109917,0,1,0,0,0,0,ZPR1 zinc finger,ZPR1,1
+ENSG00000242683,0,1,0,0,0,0,NA,NA,1
+ENSG00000237649,0,1,0,0,0,0,kinesin family member C1,KIFC1,1
+ENSG00000163586,0,1,0,0,0,0,fatty acid binding protein 1,FABP1,1
+ENSG00000250486,0,1,0,0,0,0,family with sequence similarity 218 member A,FAM218A,1
+ENSG00000139793,0,1,0,0,0,0,muscleblind like splicing regulator 2,MBNL2,1
+ENSG00000165219,0,1,0,0,0,0,GTPase activating protein and VPS9 domains 1,GAPVD1,1
+ENSG00000106013,0,1,0,0,0,0,ankyrin repeat domain 7,ANKRD7,1
+ENSG00000100884,0,1,0,0,0,0,copine 6,CPNE6,1
+ENSG00000154864,0,1,0,0,0,0,piezo type mechanosensitive ion channel component 2,PIEZO2,1
+ENSG00000091656,0,1,0,0,0,0,zinc finger homeobox 4,ZFHX4,1
+ENSG00000107679,0,1,0,0,0,0,pleckstrin homology domain containing A1,PLEKHA1,1
+ENSG00000107798,0,1,0,0,0,0,"lipase A, lysosomal acid type",LIPA,1
+ENSG00000255154,0,1,0,0,0,0,hydroxyacyl-thioester dehydratase type 2,HTD2,1
+ENSG00000099840,0,1,0,0,0,0,IZUMO family member 4,IZUMO4,1
+ENSG00000198569,0,1,0,0,0,0,solute carrier family 34 member 3,SLC34A3,1
+ENSG00000180815,0,1,0,0,0,0,mitogen-activated protein kinase kinase kinase 15,MAP3K15,1
+ENSG00000125864,0,1,0,0,0,0,beaded filament structural protein 1,BFSP1,1
+ENSG00000186470,0,1,0,0,0,0,butyrophilin subfamily 3 member A2,BTN3A2,1
+ENSG00000239887,0,1,0,0,0,0,chromosome 1 open reading frame 226,C1orf226,1
+ENSG00000196476,0,1,0,0,0,0,chromosome 20 open reading frame 96,C20orf96,1
+ENSG00000196118,0,1,0,0,0,0,cilia and flagella associated protein 119,CFAP119,1
+ENSG00000151725,0,1,0,0,0,0,centromere protein U,CENPU,1
+ENSG00000176108,0,1,0,0,0,0,charged multivesicular body protein 6,CHMP6,1
+ENSG00000172409,0,1,0,0,0,0,cleavage factor polyribonucleotide kinase subunit 1,CLP1,1
+ENSG00000068438,0,1,0,0,0,0,FtsJ RNA 2'-O-methyltransferase 1,FTSJ1,1
+ENSG00000111087,0,1,0,0,0,0,GLI family zinc finger 1,GLI1,1
+ENSG00000180573,0,1,0,0,0,0,H2A clustered histone 6,H2AC6,1
+ENSG00000004776,0,1,0,0,0,0,heat shock protein family B (small) member 6,HSPB6,1
+ENSG00000034152,0,1,0,0,0,0,mitogen-activated protein kinase kinase 3,MAP2K3,1
+ENSG00000101608,0,1,0,0,0,0,myosin light chain 12A,MYL12A,1
+ENSG00000173376,0,1,0,0,0,0,neuron derived neurotrophic factor,NDNF,1
+ENSG00000184207,0,1,0,0,0,0,phosphoglycolate phosphatase,PGP,1
+ENSG00000149809,0,1,0,0,0,0,transmembrane 7 superfamily member 2,TM7SF2,1
+ENSG00000115282,0,1,0,0,0,0,tetratricopeptide repeat domain 31,TTC31,1
+ENSG00000236474,0,0,1,0,0,0,NA,NA,1
+ENSG00000254512,0,0,1,0,0,0,NA,NA,1
+ENSG00000183638,0,0,1,0,0,0,RP1 like 1,RP1L1,1
+ENSG00000166435,0,0,1,0,0,0,X-ray radiation resistance associated 1,XRRA1,1
+ENSG00000259339,0,0,1,0,0,0,NA,NA,1
+ENSG00000198064,0,0,1,0,0,0,"nuclear pore complex interacting protein family, member B13",NPIPB13,1
+ENSG00000259318,0,0,1,0,0,0,NA,NA,1
+ENSG00000212643,0,0,1,0,0,0,ZRSR2 pseudogene 1,ZRSR2P1,1
+ENSG00000104835,0,0,1,0,0,0,"seryl-tRNA synthetase 2, mitochondrial",SARS2,1
+ENSG00000114374,0,0,1,0,0,0,ubiquitin specific peptidase 9 Y-linked,USP9Y,1
+ENSG00000114374,0,0,1,0,0,0,"testis-specific transcript, Y-linked 15",TTTY15,1
+ENSG00000117500,0,0,1,0,0,0,transmembrane p24 trafficking protein 5,TMED5,1
+ENSG00000174501,0,0,1,0,0,0,ankyrin repeat domain 36C,ANKRD36C,1
+ENSG00000215165,0,0,1,0,0,0,NA,NA,1
+ENSG00000059588,0,0,1,0,0,0,TAR (HIV-1) RNA binding protein 1,TARBP1,1
+ENSG00000234227,0,0,1,0,0,0,ribosomal protein L7 like 1 pseudogene 1,RPL7L1P1,1
+ENSG00000204866,0,0,1,0,0,0,IGF like family member 2,IGFL2,1
+ENSG00000188624,0,0,1,0,0,0,IGF like family member 3,IGFL3,1
+ENSG00000088320,0,0,1,0,0,0,RRAD and GEM like GTPase 1,REM1,1
+ENSG00000206538,0,0,1,0,0,0,vestigial like family member 3,VGLL3,1
+ENSG00000235674,0,0,1,0,0,0,NA,NA,1
+ENSG00000258890,0,0,1,0,0,0,centrosomal protein 95,CEP95,1
+ENSG00000177984,0,0,1,0,0,0,lipocalin 15,LCN15,1
+ENSG00000241697,0,0,1,0,0,0,transmembrane protein with EGF like and two follistatin like domains 1,TMEFF1,1
+ENSG00000237406,0,0,1,0,0,0,"NADH:ubiquinone oxidoreductase subunit A9 pseudogene 1",NDUFA9P1,1
+ENSG00000105404,0,0,1,0,0,0,Rab acceptor 1,RABAC1,1
+ENSG00000167202,0,0,1,0,0,0,TBC1 domain family member 2B,TBC1D2B,1
+ENSG00000218186,0,0,1,0,0,0,keratin 8 pseudogene 43,KRT8P43,1
+ENSG00000168096,0,0,1,0,0,0,ankyrin repeat and sterile alpha motif domain containing 3,ANKS3,1
+ENSG00000109084,0,0,1,0,0,0,transmembrane protein 97,TMEM97,1
+ENSG00000143344,0,0,1,0,0,0,ral guanine nucleotide dissociation stimulator like 1,RGL1,1
+ENSG00000035403,0,0,1,0,0,0,vinculin,VCL,1
+ENSG00000162241,0,0,1,0,0,0,solute carrier family 25 member 45,SLC25A45,1
+ENSG00000158683,0,0,1,0,0,0,"polycystin 1 like 1, transient receptor potential channel interacting",PKD1L1,1
+ENSG00000269343,0,0,1,0,0,0,zinc finger protein 587B,ZNF587B,1
+ENSG00000180708,0,0,1,0,0,0,olfactory receptor family 10 subfamily K member 2,OR10K2,1
+ENSG00000214244,0,0,1,0,0,0,NA,NA,1
+ENSG00000187391,0,0,1,0,0,0,"membrane associated guanylate kinase, WW and PDZ domain containing 2",MAGI2,1
+ENSG00000273762,0,0,1,0,0,0,vomeronasal 1 receptor 76 pseudogene,VN1R76P,1
+ENSG00000258932,0,0,1,0,0,0,uncharacterized LOC728755,LOC728755,1
+ENSG00000183604,0,0,1,0,0,0,SMG1 pseudogene 5,SMG1P5,1
+ENSG00000138472,0,0,1,0,0,0,guanylate cyclase activator 1C,GUCA1C,1
+ENSG00000105186,0,0,1,0,0,0,ankyrin repeat domain 27,ANKRD27,1
+ENSG00000160117,0,0,1,0,0,0,ankyrin repeat and LEM domain containing 1,ANKLE1,1
+ENSG00000257966,0,0,1,0,0,0,NA,NA,1
+ENSG00000161642,0,0,1,0,0,0,zinc finger protein 385A,ZNF385A,1
+ENSG00000136542,0,0,1,0,0,0,polypeptide N-acetylgalactosaminyltransferase 5,GALNT5,1
+ENSG00000259378,0,0,1,0,0,0,NA,NA,1
+ENSG00000185031,0,0,1,0,0,0,NA,NA,1
+ENSG00000251400,0,0,1,0,0,0,aldehyde dehydrogenase 7 family member A1 pseudogene 1,ALDH7A1P1,1
+ENSG00000227331,0,0,1,0,0,0,ribosomal protein L7a pseudogene 22,RPL7AP22,1
+ENSG00000088356,0,0,1,0,0,0,p53 and DNA damage regulated 1,PDRG1,1
+ENSG00000206159,0,0,1,0,0,0,glycogenin 2 pseudogene 1,GYG2P1,1
+ENSG00000257195,0,0,1,0,0,0,NA,NA,1
+ENSG00000214988,0,0,1,0,0,0,ribosomal protein L7a pseudogene 26,RPL7AP26,1
+ENSG00000160049,0,0,1,0,0,0,DNA fragmentation factor subunit alpha,DFFA,1
+ENSG00000139547,0,0,1,0,0,0,retinol dehydrogenase 16,RDH16,1
+ENSG00000107882,0,0,1,0,0,0,SUFU negative regulator of hedgehog signaling,SUFU,1
+ENSG00000188001,0,0,1,0,0,0,tumor protein p63 regulated 1,TPRG1,1
+ENSG00000140259,0,0,1,0,0,0,microfibril associated protein 1,MFAP1,1
+ENSG00000127589,0,0,1,0,0,0,tubulin beta pseudogene 1,TUBBP1,1
+ENSG00000243716,0,0,1,0,0,0,nuclear pore complex interacting protein family member B5,NPIPB5,1
+ENSG00000232230,0,0,1,0,0,0,NA,NA,1
+ENSG00000196839,0,0,1,0,0,0,adenosine deaminase,ADA,1
+ENSG00000134759,0,0,1,0,0,0,elongator acetyltransferase complex subunit 2,ELP2,1
+ENSG00000161981,0,0,1,0,0,0,small nuclear ribonucleoprotein U11/U12 subunit 25,SNRNP25,1
+ENSG00000123473,0,0,1,0,0,0,STIL centriolar assembly protein,STIL,1
+ENSG00000272636,0,0,1,0,0,0,double C2 domain beta,DOC2B,1
+ENSG00000167779,0,0,1,0,0,0,insulin like growth factor binding protein 6,IGFBP6,1
+ENSG00000073282,0,0,1,0,0,0,tumor protein p63,TP63,1
+ENSG00000165685,0,0,1,0,0,0,transmembrane protein 52B,TMEM52B,1
+ENSG00000138435,0,0,1,0,0,0,cholinergic receptor nicotinic alpha 1 subunit,CHRNA1,1
+ENSG00000141744,0,0,1,0,0,0,phenylethanolamine N-methyltransferase,PNMT,1
+ENSG00000134007,0,0,1,0,0,0,ADAM metallopeptidase domain 20,ADAM20,1
+ENSG00000189292,0,0,1,0,0,0,ALK and LTK ligand 2,ALKAL2,1
+ENSG00000135678,0,0,1,0,0,0,carboxypeptidase M,CPM,1
+ENSG00000177663,0,0,1,0,0,0,interleukin 17 receptor A,IL17RA,1
+ENSG00000124733,0,0,1,0,0,0,male-enhanced antigen 1,MEA1,1
+ENSG00000121039,0,0,1,0,0,0,retinol dehydrogenase 10,RDH10,1
+ENSG00000116205,0,0,1,0,0,0,transcription elongation factor A N-terminal and central domain containing 2,TCEANC2,1
+ENSG00000123610,0,0,1,0,0,0,TNF alpha induced protein 6,TNFAIP6,1
+ENSG00000171970,0,0,1,0,0,0,zinc finger protein 57,ZNF57,1
+ENSG00000197057,0,0,0,1,0,0,death domain containing 1,DTHD1,1
+ENSG00000179813,0,0,0,1,0,0,family with sequence similarity 216 member B,FAM216B,1
+ENSG00000213085,0,0,0,1,0,0,cilia and flagella associated protein 45,CFAP45,1
+ENSG00000185149,0,0,0,1,0,0,neuropeptide Y receptor Y2,NPY2R,1
+ENSG00000268500,0,0,0,1,0,0,sialic acid binding Ig like lectin 5,SIGLEC5,1
+ENSG00000089041,0,0,0,1,0,0,purinergic receptor P2X 7,P2RX7,1
+ENSG00000170160,0,0,0,1,0,0,coiled-coil domain containing 144A,CCDC144A,1
+ENSG00000197171,0,0,0,1,0,0,uncharacterized LOC101929006,LOC101929006,1
+ENSG00000188933,0,0,0,1,0,0,ubiquitin specific peptidase 32 pseudogene 1,USP32P1,1
+ENSG00000077327,0,0,0,1,0,0,sperm associated antigen 6,SPAG6,1
+ENSG00000118492,0,0,0,1,0,0,androglobin,ADGB,1
+ENSG00000112761,0,0,0,1,0,0,cellular communication network factor 6,CCN6,1
+ENSG00000166387,0,0,0,1,0,0,PPFIA binding protein 2,PPFIBP2,1
+ENSG00000155287,0,0,0,1,0,0,solute carrier family 25 member 28,SLC25A28,1
+ENSG00000183458,0,0,0,1,0,0,"polycystin 1, transient receptor potential channel interacting pseudogene 3",PKD1P3,1
+ENSG00000197177,0,0,0,1,0,0,adhesion G protein-coupled receptor A1,ADGRA1,1
+ENSG00000131002,0,0,0,1,0,0,"taxilin gamma pseudogene, Y-linked",TXLNGY,1
+ENSG00000169258,0,0,0,1,0,0,G protein regulated inducer of neurite outgrowth 1,GPRIN1,1
+ENSG00000100625,0,0,0,1,0,0,SIX homeobox 4,SIX4,1
+ENSG00000114784,0,0,0,1,0,0,eukaryotic translation initiation factor 1B,EIF1B,1
+ENSG00000162643,0,0,0,1,0,0,dynein axonemal intermediate chain 3,DNAI3,1
+ENSG00000055118,0,0,0,1,0,0,potassium voltage-gated channel subfamily H member 2,KCNH2,1
+ENSG00000090238,0,0,0,1,0,0,yippee like 3,YPEL3,1
+ENSG00000198815,0,0,0,1,0,0,forkhead box J3,FOXJ3,1
+ENSG00000129009,0,0,0,1,0,0,immunoglobulin superfamily containing leucine rich repeat,ISLR,1
+ENSG00000166448,0,0,0,1,0,0,transmembrane protein 130,TMEM130,1
+ENSG00000140488,0,0,0,1,0,0,CUGBP Elav-like family member 6,CELF6,1
+ENSG00000151092,0,0,0,1,0,0,N-glycanase 1,NGLY1,1
+ENSG00000178397,0,0,0,1,0,0,family with sequence similarity 220 member A,FAM220A,1
+ENSG00000131323,0,0,0,1,0,0,TNF receptor associated factor 3,TRAF3,1
+ENSG00000101945,0,0,0,1,0,0,SUV39H1 histone lysine methyltransferase,SUV39H1,1
+ENSG00000118689,0,0,0,1,0,0,forkhead box O3,FOXO3,1
+ENSG00000136156,0,0,0,1,0,0,integral membrane protein 2B,ITM2B,1
+ENSG00000150051,0,0,0,1,0,0,mohawk homeobox,MKX,1
+ENSG00000114354,0,0,0,1,0,0,trafficking from ER to golgi regulator,TFG,1
+ENSG00000138623,0,0,0,1,0,0,semaphorin 7A (John Milton Hagen blood group),SEMA7A,1
+ENSG00000105976,0,0,0,1,0,0,"MET proto-oncogene, receptor tyrosine kinase",MET,1
+ENSG00000157502,0,0,0,1,0,0,PWWP domain containing 3B,PWWP3B,1
+ENSG00000122034,0,0,0,1,0,0,general transcription factor IIIA,GTF3A,1
+ENSG00000159840,0,0,0,1,0,0,zyxin,ZYX,1
+ENSG00000198133,0,0,0,1,0,0,transmembrane protein 229B,TMEM229B,1
+ENSG00000197826,0,0,0,1,0,0,cilia and flagella associated protein 299,CFAP299,1
+ENSG00000257591,0,0,0,1,0,0,zinc finger protein 625,ZNF625,1
+ENSG00000144191,0,0,0,1,0,0,cyclic nucleotide gated channel subunit alpha 3,CNGA3,1
+ENSG00000107404,0,0,0,1,0,0,dishevelled segment polarity protein 1,DVL1,1
+ENSG00000166840,0,0,0,1,0,0,glycine-N-acyltransferase like 1,GLYATL1,1
+ENSG00000165175,0,0,0,1,0,0,MID1 interacting protein 1,MID1IP1,1
+ENSG00000170185,0,0,0,1,0,0,ubiquitin specific peptidase 38,USP38,1
+ENSG00000137166,0,0,0,1,0,0,forkhead box P4,FOXP4,1
+ENSG00000188042,0,0,0,1,0,0,ADP ribosylation factor like GTPase 4C,ARL4C,1
+ENSG00000164087,0,0,0,1,0,0,POC1 centriolar protein A,POC1A,1
+ENSG00000146469,0,0,0,1,0,0,vasoactive intestinal peptide,VIP,1
+ENSG00000128564,0,0,0,1,0,0,VGF nerve growth factor inducible,VGF,1
+ENSG00000133639,0,0,0,1,0,0,BTG anti-proliferation factor 1,BTG1,1
+ENSG00000163032,0,0,0,1,0,0,visinin like 1,VSNL1,1
+ENSG00000178602,0,0,0,1,0,0,otospiralin,OTOS,1
+ENSG00000078098,0,0,0,1,0,0,fibroblast activation protein alpha,FAP,1
+ENSG00000196843,0,0,0,1,0,0,AT-rich interaction domain 5A,ARID5A,1
+ENSG00000079101,0,0,0,1,0,0,clusterin like 1,CLUL1,1
+ENSG00000169203,0,0,0,1,0,0,nuclear pore complex interacting protein family member B12,NPIPB12,1
+ENSG00000155087,0,0,0,1,0,0,outer dense fiber of sperm tails 1,ODF1,1
+ENSG00000197208,0,0,0,1,0,0,solute carrier family 22 member 4,SLC22A4,1
+ENSG00000121900,0,0,0,1,0,0,transmembrane protein 54,TMEM54,1
+ENSG00000105048,0,0,0,1,0,0,"troponin T1, slow skeletal type",TNNT1,1
+ENSG00000241343,0,0,0,0,1,0,ribosomal protein L36a,RPL36A,1
+ENSG00000122566,0,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein A2/B1,HNRNPA2B1,1
+ENSG00000089335,0,0,0,0,1,0,zinc finger protein 302,ZNF302,1
+ENSG00000244687,0,0,0,0,1,0,ubiquitin conjugating enzyme E2 V1,UBE2V1,1
+ENSG00000198938,0,0,0,0,1,0,cytochrome c oxidase subunit III,COX3,1
+ENSG00000184208,0,0,0,0,1,0,CTA-216E10.6,C22orf46,1
+ENSG00000196235,0,0,0,0,1,0,"SPT5 homolog, DSIF elongation factor subunit",SUPT5H,1
+ENSG00000112357,0,0,0,0,1,0,peroxisomal biogenesis factor 7,PEX7,1
+ENSG00000180953,0,0,0,0,1,0,suppressor of tumorigenicity 20,ST20,1
+ENSG00000135486,0,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein A1,HNRNPA1,1
+ENSG00000155506,0,0,0,0,1,0,"La ribonucleoprotein 1, translational regulator",LARP1,1
+ENSG00000096746,0,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein H3,HNRNPH3,1
+ENSG00000182247,0,0,0,0,1,0,ubiquitin conjugating enzyme E2 E2,UBE2E2,1
+ENSG00000131469,0,0,0,0,1,0,ribosomal protein L27,RPL27,1
+ENSG00000162755,0,0,0,0,1,0,kelch domain containing 9,KLHDC9,1
+ENSG00000105372,0,0,0,0,1,0,ribosomal protein S19,RPS19,1
+ENSG00000189089,0,0,0,0,1,0,NA,NA,1
+ENSG00000099785,0,0,0,0,1,0,membrane associated ring-CH-type finger 2,MARCHF2,1
+ENSG00000125386,0,0,0,0,1,0,family with sequence similarity 193 member A,FAM193A,1
+ENSG00000181038,0,0,0,0,1,0,methyltransferase like 23,METTL23,1
+ENSG00000101361,0,0,0,0,1,0,NOP56 ribonucleoprotein,NOP56,1
+ENSG00000130816,0,0,0,0,1,0,DNA methyltransferase 1,DNMT1,1
+ENSG00000179085,0,0,0,0,1,0,"dolichyl-phosphate mannosyltransferase subunit 3, regulatory",DPM3,1
+ENSG00000166444,0,0,0,0,1,0,DENN domain containing 2B,DENND2B,1
+ENSG00000198918,0,0,0,0,1,0,ribosomal protein L39,RPL39,1
+ENSG00000165215,0,0,0,0,1,0,claudin 3,CLDN3,1
+ENSG00000166974,0,0,0,0,1,0,microtubule associated protein RP/EB family member 2,MAPRE2,1
+ENSG00000184924,0,0,0,0,1,0,peptidyl-tRNA hydrolase domain containing 1,PTRHD1,1
+ENSG00000186665,0,0,0,0,1,0,chromosome 17 open reading frame 58,C17orf58,1
+ENSG00000111752,0,0,0,0,1,0,polyhomeotic homolog 1,PHC1,1
+ENSG00000124614,0,0,0,0,1,0,ribosomal protein S10,RPS10,1
+ENSG00000275023,0,0,0,0,1,0,"MLLT6, PHD finger containing",MLLT6,1
+ENSG00000213235,0,0,0,0,1,0,eukaryotic translation elongation factor 1 alpha 1 pseudogene 16,EEF1A1P16,1
+ENSG00000249768,0,0,0,0,1,0,NA,NA,1
+ENSG00000167257,0,0,0,0,1,0,ring finger protein 214,RNF214,1
+ENSG00000168056,0,0,0,0,1,0,latent transforming growth factor beta binding protein 3,LTBP3,1
+ENSG00000254870,0,0,0,0,1,0,ATP6V1G2-DDX39B readthrough (NMD candidate),ATP6V1G2-DDX39B,1
+ENSG00000112182,0,0,0,0,1,0,BTB domain and CNC homolog 2,BACH2,1
+ENSG00000117410,0,0,0,0,1,0,ATPase H+ transporting V0 subunit b,ATP6V0B,1
+ENSG00000130939,0,0,0,0,1,0,ubiquitination factor E4B,UBE4B,1
+ENSG00000108349,0,0,0,0,1,0,CASC3 exon junction complex subunit,CASC3,1
+ENSG00000136536,0,0,0,0,1,0,membrane associated ring-CH-type finger 7,MARCHF7,1
+ENSG00000126005,0,0,0,0,1,0,MMP24 opposite strand,MMP24OS,1
+ENSG00000248527,0,0,0,0,1,0,MT-ATP6 pseudogene 1,MTATP6P1,1
+ENSG00000123213,0,0,0,0,1,0,neurolysin,NLN,1
+ENSG00000127616,0,0,0,0,1,0,"SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4",SMARCA4,1
+ENSG00000183978,0,0,0,0,1,0,cytochrome c oxidase assembly factor 3,COA3,1
+ENSG00000116560,0,0,0,0,1,0,splicing factor proline and glutamine rich,SFPQ,1
+ENSG00000129480,0,0,0,0,1,0,D-aminoacyl-tRNA deacylase 2,DTD2,1
+ENSG00000088367,0,0,0,0,1,0,erythrocyte membrane protein band 4.1 like 1,EPB41L1,1
+ENSG00000117713,0,0,0,0,1,0,AT-rich interaction domain 1A,ARID1A,1
+ENSG00000110066,0,0,0,0,1,0,lysine methyltransferase 5B,KMT5B,1
+ENSG00000185710,0,0,0,0,1,0,SMG1 pseudogene 4,SMG1P4,1
+ENSG00000132478,0,0,0,0,1,0,unk zinc finger,UNK,1
+ENSG00000184640,0,0,0,0,1,0,septin 9,SEPTIN9,1
+ENSG00000213018,0,0,0,0,1,0,NA,NA,1
+ENSG00000115053,0,0,0,0,1,0,nucleolin,NCL,1
+ENSG00000140995,0,0,0,0,1,0,differentially expressed in FDCP 8 homolog,DEF8,1
+ENSG00000130749,0,0,0,0,1,0,zinc finger CCCH-type containing 4,ZC3H4,1
+ENSG00000242221,0,0,0,0,1,0,pregnancy specific beta-1-glycoprotein 2,PSG2,1
+ENSG00000134884,0,0,0,0,1,0,arginine and glutamate rich 1,ARGLU1,1
+ENSG00000163382,0,0,0,0,1,0,"NAD(P)HX epimerase","NAXE",1
+ENSG00000188243,0,0,0,0,1,0,COMM domain containing 6,COMMD6,1
+ENSG00000175467,0,0,0,0,1,0,"spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP",SART1,1
+ENSG00000161328,0,0,0,0,1,0,leucine rich repeat containing 56,LRRC56,1
+ENSG00000225067,0,0,0,0,1,0,NA,NA,1
+ENSG00000146067,0,0,0,0,1,0,family with sequence similarity 193 member B,FAM193B,1
+ENSG00000170632,0,0,0,0,1,0,armadillo repeat containing 10,ARMC10,1
+ENSG00000182809,0,0,0,0,1,0,cysteine rich protein 2,CRIP2,1
+ENSG00000164405,0,0,0,0,1,0,ubiquinol-cytochrome c reductase complex III subunit VII,UQCRQ,1
+ENSG00000166197,0,0,0,0,1,0,nucleolar and coiled-body phosphoprotein 1,NOLC1,1
+ENSG00000178449,0,0,0,0,1,0,cytochrome c oxidase assembly factor COX14,COX14,1
+ENSG00000204923,0,0,0,0,1,0,F-box protein 48,FBXO48,1
+ENSG00000132388,0,0,0,0,1,0,ubiquitin conjugating enzyme E2 G1,UBE2G1,1
+ENSG00000227694,0,0,0,0,1,0,ribosomal protein L23a pseudogene 74,RPL23AP74,1
+ENSG00000260266,0,0,0,0,1,0,peptidylprolyl isomerase A pseudogene 46,PPIAP46,1
+ENSG00000111843,0,0,0,0,1,0,transmembrane protein 14C,TMEM14C,1
+ENSG00000169902,0,0,0,0,1,0,tyrosylprotein sulfotransferase 1,TPST1,1
+ENSG00000142039,0,0,0,0,1,0,coiled-coil domain containing 97,CCDC97,1
+ENSG00000177576,0,0,0,0,1,0,chromosome 18 open reading frame 32,C18orf32,1
+ENSG00000127540,0,0,0,0,1,0,"ubiquinol-cytochrome c reductase, complex III subunit XI",UQCR11,1
+ENSG00000177144,0,0,0,0,1,0,nudix hydrolase 4B,NUDT4B,1
+ENSG00000145833,0,0,0,0,1,0,DEAD-box helicase 46,DDX46,1
+ENSG00000168066,0,0,0,0,1,0,splicing factor 1,SF1,1
+ENSG00000181450,0,0,0,0,1,0,zinc finger protein 678,ZNF678,1
+ENSG00000112983,0,0,0,0,1,0,bromodomain containing 8,BRD8,1
+ENSG00000177464,0,0,0,0,1,0,G protein-coupled receptor 4,GPR4,1
+ENSG00000102390,0,0,0,0,1,0,polysaccharide biosynthesis domain containing 1,PBDC1,1
+ENSG00000229415,0,0,0,0,1,0,surfactant associated 3,SFTA3,1
+ENSG00000143294,0,0,0,0,1,0,proline rich mitotic checkpoint control factor,PRCC,1
+ENSG00000152240,0,0,0,0,1,0,HAUS augmin like complex subunit 1,HAUS1,1
+ENSG00000204060,0,0,0,0,1,0,forkhead box O6,FOXO6,1
+ENSG00000167632,0,0,0,0,1,0,trafficking protein particle complex subunit 9,TRAPPC9,1
+ENSG00000113845,0,0,0,0,1,0,translocase of inner mitochondrial membrane domain containing 1,TIMMDC1,1
+ENSG00000205937,0,0,0,0,1,0,RNA binding protein with serine rich domain 1,RNPS1,1
+ENSG00000143569,0,0,0,0,1,0,ubiquitin associated protein 2 like,UBAP2L,1
+ENSG00000102524,0,0,0,0,1,0,TNF superfamily member 13b,TNFSF13B,1
+ENSG00000134419,0,0,0,0,1,0,ribosomal protein S15a,RPS15A,1
+ENSG00000204370,0,0,0,0,1,0,succinate dehydrogenase complex subunit D,SDHD,1
+ENSG00000063177,0,0,0,0,1,0,ribosomal protein L18,RPL18,1
+ENSG00000132153,0,0,0,0,1,0,DExH-box helicase 30,DHX30,1
+ENSG00000147138,0,0,0,0,1,0,G protein-coupled receptor 174,GPR174,1
+ENSG00000146063,0,0,0,0,1,0,tripartite motif containing 41,TRIM41,1
+ENSG00000178980,0,0,0,0,1,0,selenoprotein W,SELENOW,1
+ENSG00000213420,0,0,0,0,1,0,glypican 2,GPC2,1
+ENSG00000103254,0,0,0,0,1,0,adenine nucleotide translocase lysine methyltransferase,ANTKMT,1
+ENSG00000053254,0,0,0,0,1,0,forkhead box N3,FOXN3,1
+ENSG00000168002,0,0,0,0,1,0,RNA polymerase II subunit G,POLR2G,1
+ENSG00000148337,0,0,0,0,1,0,CDKN1A interacting zinc finger protein 1,CIZ1,1
+ENSG00000197472,0,0,0,0,1,0,zinc finger protein 695,ZNF695,1
+ENSG00000142408,0,0,0,0,1,0,calcium voltage-gated channel auxiliary subunit gamma 8,CACNG8,1
+ENSG00000136573,0,0,0,0,1,0,"BLK proto-oncogene, Src family tyrosine kinase",BLK,1
+ENSG00000205544,0,0,0,0,1,0,transmembrane protein 256,TMEM256,1
+ENSG00000173559,0,0,0,0,1,0,nucleic acid binding protein 1,"NABP1",1
+ENSG00000203618,0,0,0,0,1,0,glycoprotein Ib platelet subunit beta,GP1BB,1
+ENSG00000188186,0,0,0,0,1,0,"late endosomal/lysosomal adaptor, MAPK and MTOR activator 4",LAMTOR4,1
+ENSG00000054523,0,0,0,0,1,0,kinesin family member 1B,KIF1B,1
+ENSG00000089050,0,0,0,0,1,0,"RB binding protein 9, serine hydrolase",RBBP9,1
+ENSG00000126698,0,0,0,0,1,0,DnaJ heat shock protein family (Hsp40) member C8,DNAJC8,1
+ENSG00000114455,0,0,0,0,1,0,HERV-H LTR-associating 2,HHLA2,1
+ENSG00000181873,0,0,0,0,1,0,iron-sulfur cluster assembly factor IBA57,IBA57,1
+ENSG00000135363,0,0,0,0,1,0,LIM domain only 2,LMO2,1
+ENSG00000197006,0,0,0,0,1,0,methyltransferase like 9,METTL9,1
+ENSG00000118900,0,0,0,0,1,0,ubinuclein 1,UBN1,1
+ENSG00000013619,0,0,0,0,1,0,mastermind like domain containing 1,MAMLD1,1
+ENSG00000180264,0,0,0,0,1,0,adhesion G protein-coupled receptor D2,ADGRD2,1
+ENSG00000106803,0,0,0,0,1,0,SEC61 translocon subunit beta,SEC61B,1
+ENSG00000005844,0,0,0,0,1,0,integrin subunit alpha L,ITGAL,1
+ENSG00000081154,0,0,0,0,1,0,PEST proteolytic signal containing nuclear protein,PCNP,1
+ENSG00000112293,0,0,0,0,1,0,glycosylphosphatidylinositol specific phospholipase D1,GPLD1,1
+ENSG00000198019,0,0,0,0,1,0,Fc fragment of IgG receptor Ib,FCGR1B,1
+ENSG00000164393,0,0,0,0,1,0,adhesion G protein-coupled receptor F2,ADGRF2,1
+ENSG00000279800,0,0,0,0,1,0,BCL2 associated transcription factor 1 pseudogene 2,BCLAF1P2,1
+ENSG00000224578,0,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein A1 pseudogene 48,HNRNPA1P48,1
+ENSG00000176208,0,0,0,0,1,0,ATPase family AAA domain containing 5,ATAD5,1
+ENSG00000126456,0,0,0,0,1,0,interferon regulatory factor 3,IRF3,1
+ENSG00000110025,0,0,0,0,1,0,sorting nexin 15,SNX15,1
+ENSG00000103507,0,0,0,0,1,0,branched chain keto acid dehydrogenase kinase,BCKDK,1
+ENSG00000172469,0,0,0,0,1,0,mannosidase endo-alpha,MANEA,1
+ENSG00000141252,0,0,0,0,1,0,VPS53 subunit of GARP complex,VPS53,1
+ENSG00000144566,0,0,0,0,1,0,"RAB5A, member RAS oncogene family",RAB5A,1
+ENSG00000203950,0,0,0,0,1,0,retrotransposon Gag like 8A,RTL8A,1
+ENSG00000124422,0,0,0,0,1,0,ubiquitin specific peptidase 22,USP22,1
+ENSG00000090266,0,0,0,0,1,0,"NADH:ubiquinone oxidoreductase subunit B2",NDUFB2,1
+ENSG00000143774,0,0,0,0,1,0,guanylate kinase 1,GUK1,1
+ENSG00000169221,0,0,0,0,1,0,TBC1 domain family member 10B,TBC1D10B,1
+ENSG00000143570,0,0,0,0,1,0,solute carrier family 39 member 1,SLC39A1,1
+ENSG00000167085,0,0,0,0,1,0,prohibitin,PHB,1
+ENSG00000214253,0,0,0,0,1,0,"fission, mitochondrial 1",FIS1,1
+ENSG00000136715,0,0,0,0,1,0,Sin3A associated protein 130,SAP130,1
+ENSG00000204568,0,0,0,0,1,0,mitochondrial ribosomal protein S18B,MRPS18B,1
+ENSG00000134453,0,0,0,0,1,0,RNA binding motif protein 17,RBM17,1
+ENSG00000183718,0,0,0,0,1,0,tripartite motif containing 52,TRIM52,1
+ENSG00000248592,0,0,0,0,1,0,STIMATE-MUSTN1 readthrough,STIMATE-MUSTN1,1
+ENSG00000163041,0,0,0,0,1,0,H3.3 histone A,H3-3A,1
+ENSG00000156795,0,0,0,0,1,0,N-terminal glutamine amidase 1,NTAQ1,1
+ENSG00000183161,0,0,0,0,1,0,FA complementation group F,FANCF,1
+ENSG00000276291,0,0,0,0,1,0,NA,NA,1
+ENSG00000178096,0,0,0,0,1,0,bolA family member 1,BOLA1,1
+ENSG00000100804,0,0,0,0,1,0,proteasome 20S subunit beta 5,PSMB5,1
+ENSG00000079308,0,0,0,0,1,0,tensin 1,TNS1,1
+ENSG00000173011,0,0,0,0,1,0,transcriptional adaptor 2B,TADA2B,1
+ENSG00000105223,0,0,0,0,1,0,phospholipase D family member 3,PLD3,1
+ENSG00000174780,0,0,0,0,1,0,signal recognition particle 72,SRP72,1
+ENSG00000198780,0,0,0,0,1,0,family with sequence similarity 169 member A,FAM169A,1
+ENSG00000107581,0,0,0,0,1,0,eukaryotic translation initiation factor 3 subunit A,EIF3A,1
+ENSG00000124469,0,0,0,0,1,0,CEA cell adhesion molecule 8,CEACAM8,1
+ENSG00000247627,0,0,0,0,1,0,MT-ND4 pseudogene 12,MTND4P12,1
+ENSG00000169964,0,0,0,0,1,0,transmembrane protein 42,TMEM42,1
+ENSG00000170315,0,0,0,0,1,0,ubiquitin B,UBB,1
+ENSG00000112941,0,0,0,0,1,0,terminal nucleotidyltransferase 4A,TENT4A,1
+ENSG00000143222,0,0,0,0,1,0,ubiquitin-fold modifier conjugating enzyme 1,UFC1,1
+ENSG00000143379,0,0,0,0,1,0,SET domain bifurcated histone lysine methyltransferase 1,SETDB1,1
+ENSG00000137393,0,0,0,0,1,0,ring finger protein 144B,RNF144B,1
+ENSG00000185215,0,0,0,0,1,0,TNF alpha induced protein 2,TNFAIP2,1
+ENSG00000077782,0,0,0,0,1,0,fibroblast growth factor receptor 1,FGFR1,1
+ENSG00000109113,0,0,0,0,1,0,"RAB34, member RAS oncogene family",RAB34,1
+ENSG00000125691,0,0,0,0,1,0,ribosomal protein L23,RPL23,1
+ENSG00000067704,0,0,0,0,1,0,"isoleucyl-tRNA synthetase 2, mitochondrial",IARS2,1
+ENSG00000055070,0,0,0,0,1,0,SUZ RNA binding domain containing 1,SZRD1,1
+ENSG00000181804,0,0,0,0,1,0,solute carrier family 9 member A9,SLC9A9,1
+ENSG00000198744,0,0,0,0,1,0,MT-CO3 pseudogene 12,MTCO3P12,1
+ENSG00000112706,0,0,0,0,1,0,interphotoreceptor matrix proteoglycan 1,IMPG1,1
+ENSG00000183346,0,0,0,0,1,0,ciliary associated calcium binding coiled-coil 1,CABCOCO1,1
+ENSG00000127184,0,0,0,0,1,0,cytochrome c oxidase subunit 7C,COX7C,1
+ENSG00000169740,0,0,0,0,1,0,zinc finger protein 32,ZNF32,1
+ENSG00000147403,0,0,0,0,1,0,ribosomal protein L10,RPL10,1
+ENSG00000136152,0,0,0,0,1,0,component of oligomeric golgi complex 3,COG3,1
+ENSG00000132792,0,0,0,0,1,0,catenin beta like 1,CTNNBL1,1
+ENSG00000152926,0,0,0,0,1,0,zinc finger protein 117,ZNF117,1
+ENSG00000152926,0,0,0,0,1,0,ERV3-1-ZNF117 readthrough,ERV3-1-ZNF117,1
+ENSG00000112992,0,0,0,0,1,0,nicotinamide nucleotide transhydrogenase,NNT,1
+ENSG00000168060,0,0,0,0,1,0,N-acetylated alpha-linked acidic dipeptidase like 1,"NAALADL1",1
+ENSG00000106244,0,0,0,0,1,0,PDGFA associated protein 1,PDAP1,1
+ENSG00000241890,0,0,0,0,1,0,ribosomal protein L13 pseudogene 4,RPL13P4,1
+ENSG00000111203,0,0,0,0,1,0,integrin alpha FG-GAP repeat containing 2,ITFG2,1
+ENSG00000070444,0,0,0,0,1,0,MAX network transcriptional repressor,MNT,1
+ENSG00000123739,0,0,0,0,1,0,phospholipase A2 group XIIA,PLA2G12A,1
+ENSG00000186106,0,0,0,0,1,0,ankyrin repeat domain 46,ANKRD46,1
+ENSG00000141298,0,0,0,0,1,0,slingshot protein phosphatase 2,SSH2,1
+ENSG00000173041,0,0,0,0,1,0,zinc finger protein 680,ZNF680,1
+ENSG00000213920,0,0,0,0,1,0,magnesium dependent phosphatase 1,MDP1,1
+ENSG00000233163,0,0,0,0,1,0,ribosomal protein S12 pseudogene 17,RPS12P17,1
+ENSG00000104964,0,0,0,0,1,0,"TLE family member 5, transcriptional modulator",TLE5,1
+ENSG00000177628,0,0,0,0,1,0,glucosylceramidase beta,GBA,1
+ENSG00000171863,0,0,0,0,1,0,ribosomal protein S7,RPS7,1
+ENSG00000241859,0,0,0,0,1,0,NA,NA,1
+ENSG00000124787,0,0,0,0,1,0,ribonuclease P/MRP subunit p40,RPP40,1
+ENSG00000111481,0,0,0,0,1,0,COPI coat complex subunit zeta 1,COPZ1,1
+ENSG00000049245,0,0,0,0,1,0,vesicle associated membrane protein 3,VAMP3,1
+ENSG00000089737,0,0,0,0,1,0,DEAD-box helicase 24,DDX24,1
+ENSG00000261740,0,0,0,0,1,0,BOLA2-SMG1P6 readthrough,BOLA2-SMG1P6,1
+ENSG00000205765,0,0,0,0,1,0,chromosome 5 open reading frame 51,C5orf51,1
+ENSG00000189337,0,0,0,0,1,0,"kazrin, periplakin interacting protein",KAZN,1
+ENSG00000099783,0,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein M,HNRNPM,1
+ENSG00000135709,0,0,0,0,1,0,KIAA0513,KIAA0513,1
+ENSG00000196832,0,0,0,0,1,0,olfactory receptor family 11 subfamily G member 2,OR11G2,1
+ENSG00000115317,0,0,0,0,1,0,HtrA serine peptidase 2,HTRA2,1
+ENSG00000237350,0,0,0,0,1,0,NA,NA,1
+ENSG00000135766,0,0,0,0,1,0,egl-9 family hypoxia inducible factor 1,EGLN1,1
+ENSG00000111361,0,0,0,0,1,0,eukaryotic translation initiation factor 2B subunit alpha,EIF2B1,1
+ENSG00000070814,0,0,0,0,1,0,treacle ribosome biogenesis factor 1,TCOF1,1
+ENSG00000061794,0,0,0,0,1,0,mitochondrial ribosomal protein S35,MRPS35,1
+ENSG00000142453,0,0,0,0,1,0,coactivator associated arginine methyltransferase 1,CARM1,1
+ENSG00000162613,0,0,0,0,1,0,far upstream element binding protein 1,FUBP1,1
+ENSG00000183742,0,0,0,0,1,0,MET transcriptional regulator MACC1,MACC1,1
+ENSG00000164967,0,0,0,0,1,0,ribonuclease P/MRP subunit p25 like,RPP25L,1
+ENSG00000141905,0,0,0,0,1,0,nuclear factor I C,NFIC,1
+ENSG00000106733,0,0,0,0,1,0,nicotinamide riboside kinase 1,NMRK1,1
+ENSG00000127922,0,0,0,0,1,0,SEM1 26S proteasome subunit,SEM1,1
+ENSG00000119559,0,0,0,0,1,0,chromosome 19 open reading frame 25,C19orf25,1
+ENSG00000178597,0,0,0,0,1,0,prosaposin like 1,PSAPL1,1
+ENSG00000278505,0,0,0,0,1,0,chromosome 17 open reading frame 78,C17orf78,1
+ENSG00000110665,0,0,0,0,1,0,chromosome 11 open reading frame 21,C11orf21,1
+ENSG00000135778,0,0,0,0,1,0,"nucleoside-triphosphatase, cancer-related",NTPCR,1
+ENSG00000188783,0,0,0,0,1,0,proline and arginine rich end leucine rich repeat protein,PRELP,1
+ENSG00000164587,0,0,0,0,1,0,ribosomal protein S14,RPS14,1
+ENSG00000164331,0,0,0,0,1,0,ankyrin repeat family A member 2,ANKRA2,1
+ENSG00000123349,0,0,0,0,1,0,prefoldin subunit 5,PFDN5,1
+ENSG00000011638,0,0,0,0,1,0,lipid droplet assembly factor 1,LDAF1,1
+ENSG00000037042,0,0,0,0,1,0,tubulin gamma 2,TUBG2,1
+ENSG00000170296,0,0,0,0,1,0,GABA type A receptor-associated protein,GABARAP,1
+ENSG00000225366,0,0,0,0,1,0,teratocarcinoma-derived growth factor 1 pseudogene 3,TDGF1P3,1
+ENSG00000227152,0,0,0,0,1,0,olfactory receptor family 2 subfamily T member 7,OR2T7,1
+ENSG00000135211,0,0,0,0,1,0,transmembrane protein 60,TMEM60,1
+ENSG00000235655,0,0,0,0,1,0,NA,NA,1
+ENSG00000077721,0,0,0,0,1,0,ubiquitin conjugating enzyme E2 A,UBE2A,1
+ENSG00000144063,0,0,0,0,1,0,"mal, T cell differentiation protein like",MALL,1
+ENSG00000186468,0,0,0,0,1,0,ribosomal protein S23,RPS23,1
+ENSG00000232938,0,0,0,0,1,0,ribosomal protein L23a pseudogene 87,RPL23AP87,1
+ENSG00000204576,0,0,0,0,1,0,proline rich 3,PRR3,1
+ENSG00000084731,0,0,0,0,1,0,kinesin family member 3C,KIF3C,1
+ENSG00000129968,0,0,0,0,1,0,"abhydrolase domain containing 17A, depalmitoylase",ABHD17A,1
+ENSG00000181524,0,0,0,0,1,0,RPL24 pseudogene 4,RPL24P4,1
+ENSG00000181126,0,0,0,0,1,0,"major histocompatibility complex, class I, V (pseudogene)",HLA-V,1
+ENSG00000243147,0,0,0,0,1,0,mitochondrial ribosomal protein L33,MRPL33,1
+ENSG00000213816,0,0,0,0,1,0,NA,NA,1
+ENSG00000183814,0,0,0,0,1,0,lin-9 DREAM MuvB core complex component,LIN9,1
+ENSG00000151779,0,0,0,0,1,0,NBAS subunit of NRZ tethering complex,NBAS,1
+ENSG00000100316,0,0,0,0,1,0,ribosomal protein L3,RPL3,1
+ENSG00000188766,0,0,0,0,1,0,sprouty related EVH1 domain containing 3,SPRED3,1
+ENSG00000066827,0,0,0,0,1,0,zinc finger and AT-hook domain containing,ZFAT,1
+ENSG00000008056,0,0,0,0,1,0,synapsin I,SYN1,1
+ENSG00000165672,0,0,0,0,1,0,peroxiredoxin 3,PRDX3,1
+ENSG00000233503,0,0,0,0,1,0,heterogeneous nuclear ribonucleoprotein L pseudogene 1,HNRNPLP1,1
+ENSG00000104808,0,0,0,0,1,0,dihydrodiol dehydrogenase,DHDH,1
+ENSG00000175595,0,0,0,0,1,0,"ERCC excision repair 4, endonuclease catalytic subunit",ERCC4,1
+ENSG00000170516,0,0,0,0,1,0,cytochrome c oxidase subunit 7B2,COX7B2,1
+ENSG00000143742,0,0,0,0,1,0,signal recognition particle 9,SRP9,1
+ENSG00000111653,0,0,0,0,1,0,inhibitor of growth family member 4,ING4,1
+ENSG00000111639,0,0,0,0,1,0,mitochondrial ribosomal protein L51,MRPL51,1
+ENSG00000163214,0,0,0,0,1,0,DExH-box helicase 57,DHX57,1
+ENSG00000092978,0,0,0,0,1,0,G-patch domain containing 2,GPATCH2,1
+ENSG00000122565,0,0,0,0,1,0,chromobox 3,CBX3,1
+ENSG00000160633,0,0,0,0,1,0,scaffold attachment factor B,SAFB,1
+ENSG00000166797,0,0,0,0,1,0,cytosolic iron-sulfur assembly component 2A,CIAO2A,1
+ENSG00000128274,0,0,0,0,1,0,"alpha 1,4-galactosyltransferase (P blood group)",A4GALT,1
+ENSG00000203761,0,0,0,0,1,0,NA,NA,1
+ENSG00000143947,0,0,0,0,1,0,ribosomal protein S27a,RPS27A,1
+ENSG00000089280,0,0,0,0,1,0,FUS RNA binding protein,FUS,1
+ENSG00000106153,0,0,0,0,1,0,coiled-coil-helix-coiled-coil-helix domain containing 2,CHCHD2,1
+ENSG00000081041,0,0,0,0,1,0,C-X-C motif chemokine ligand 2,CXCL2,1
+ENSG00000117280,0,0,0,0,1,0,"RAB29, member RAS oncogene family",RAB29,1
+ENSG00000164096,0,0,0,0,1,0,chromosome 4 open reading frame 3,C4orf3,1
+ENSG00000134698,0,0,0,0,1,0,argonaute RISC component 4,AGO4,1
+ENSG00000145354,0,0,0,0,1,0,CDGSH iron sulfur domain 2,CISD2,1
+ENSG00000145736,0,0,0,0,1,0,general transcription factor IIH subunit 2,GTF2H2,1
+ENSG00000145736,0,0,0,0,1,0,GTF2H2 family member C,GTF2H2C,1
+ENSG00000130811,0,0,0,0,1,0,eukaryotic translation initiation factor 3 subunit G,EIF3G,1
+ENSG00000110075,0,0,0,0,1,0,protein phosphatase 6 regulatory subunit 3,PPP6R3,1
+ENSG00000100354,0,0,0,0,1,0,trinucleotide repeat containing adaptor 6B,TNRC6B,1
+ENSG00000127022,0,0,0,0,1,0,calnexin,CANX,1
+ENSG00000180008,0,0,0,0,1,0,suppressor of cytokine signaling 4,SOCS4,1
+ENSG00000100650,0,0,0,0,1,0,serine and arginine rich splicing factor 5,SRSF5,1
+ENSG00000136379,0,0,0,0,1,0,"abhydrolase domain containing 17C, depalmitoylase",ABHD17C,1
+ENSG00000102245,0,0,0,0,1,0,CD40 ligand,CD40LG,1
+ENSG00000104687,0,0,0,0,1,0,glutathione-disulfide reductase,GSR,1
+ENSG00000148303,0,0,0,0,1,0,ribosomal protein L7a,RPL7A,1
+ENSG00000231584,0,0,0,0,1,0,"fumarylacetoacetate hydrolase domain containing 2C, pseudogene",FAHD2CP,1
+ENSG00000178385,0,0,0,0,1,0,pleckstrin homology domain containing M3,PLEKHM3,1
+ENSG00000108561,0,0,0,0,1,0,complement C1q binding protein,C1QBP,1
+ENSG00000184182,0,0,0,0,1,0,ubiquitin conjugating enzyme E2 F (putative),UBE2F,1
+ENSG00000277149,0,0,0,0,1,0,tRNA-yW synthesizing protein 1 homolog B,TYW1B,1
+ENSG00000154582,0,0,0,0,1,0,elongin C,ELOC,1
+ENSG00000101473,0,0,0,0,1,0,acyl-CoA thioesterase 8,ACOT8,1
+ENSG00000142541,0,0,0,0,1,0,ribosomal protein L13a,RPL13A,1
+ENSG00000118096,0,0,0,0,1,0,intraflagellar transport 46,IFT46,1
+ENSG00000158296,0,0,0,0,1,0,solute carrier family 13 member 3,SLC13A3,1
+ENSG00000122642,0,0,0,0,1,0,FKBP prolyl isomerase 9,FKBP9,1
+ENSG00000158201,0,0,0,0,1,0,"abhydrolase domain containing 3, phospholipase",ABHD3,1
+ENSG00000066027,0,0,0,0,1,0,protein phosphatase 2 regulatory subunit B'alpha,PPP2R5A,1
+ENSG00000156097,0,0,0,0,1,0,G protein-coupled receptor 61,GPR61,1
+ENSG00000179632,0,0,0,0,1,0,"MAF1 homolog, negative regulator of RNA polymerase III",MAF1,1
+ENSG00000243943,0,0,0,0,1,0,zinc finger protein 512,ZNF512,1
+ENSG00000172456,0,0,0,0,1,0,FGGY carbohydrate kinase domain containing,FGGY,1
+ENSG00000180776,0,0,0,0,1,0,zinc finger DHHC-type palmitoyltransferase 20,ZDHHC20,1
+ENSG00000106615,0,0,0,0,1,0,"Ras homolog, mTORC1 binding",RHEB,1
+ENSG00000100941,0,0,0,0,1,0,"pinin, desmosome associated protein",PNN,1
+ENSG00000155980,0,0,0,0,1,0,kinesin family member 5A,KIF5A,1
+ENSG00000104904,0,0,0,0,1,0,ornithine decarboxylase antizyme 1,OAZ1,1
+ENSG00000116288,0,0,0,0,1,0,Parkinsonism associated deglycase,PARK7,1
+ENSG00000277053,0,0,0,0,1,0,general transcription factor IIi pseudogene 1,GTF2IP1,1
+ENSG00000072501,0,0,0,0,1,0,structural maintenance of chromosomes 1A,SMC1A,1
+ENSG00000168291,0,0,0,0,1,0,pyruvate dehydrogenase E1 subunit beta,PDHB,1
+ENSG00000159147,0,0,0,0,1,0,DNA replication fork stabilization factor DONSON,DONSON,1
+ENSG00000198855,0,0,0,0,1,0,FIC domain protein adenylyltransferase,FICD,1
+ENSG00000049540,0,0,0,0,1,0,elastin,ELN,1
+ENSG00000099203,0,0,0,0,1,0,transmembrane p24 trafficking protein 1,TMED1,1
+ENSG00000111011,0,0,0,0,1,0,arginine and serine rich coiled-coil 2,RSRC2,1
+ENSG00000153253,0,0,0,0,1,0,sodium voltage-gated channel alpha subunit 3,SCN3A,1
+ENSG00000149972,0,0,0,0,1,0,contactin 5,CNTN5,1
+ENSG00000117118,0,0,0,0,1,0,succinate dehydrogenase complex iron sulfur subunit B,SDHB,1
+ENSG00000109846,0,0,0,0,1,0,crystallin alpha B,CRYAB,1
+ENSG00000173812,0,0,0,0,1,0,eukaryotic translation initiation factor 1,EIF1,1
+ENSG00000111057,0,0,0,0,1,0,keratin 18,KRT18,1
+ENSG00000136943,0,0,0,0,1,0,cathepsin V,CTSV,1
+ENSG00000073921,0,0,0,0,1,0,phosphatidylinositol binding clathrin assembly protein,PICALM,1
+ENSG00000100280,0,0,0,0,1,0,adaptor related protein complex 1 subunit beta 1,AP1B1,1
+ENSG00000145757,0,0,0,0,1,0,spermatogenesis associated 9,SPATA9,1
+ENSG00000164535,0,0,0,0,1,0,diacylglycerol lipase beta,DAGLB,1
+ENSG00000102316,0,0,0,0,1,0,MAGE family member D2,MAGED2,1
+ENSG00000182552,0,0,0,0,1,0,RWD domain containing 4,RWDD4,1
+ENSG00000135404,0,0,0,0,1,0,CD63 molecule,CD63,1
+ENSG00000139291,0,0,0,0,1,0,transmembrane protein 19,TMEM19,1
+ENSG00000112701,0,0,0,0,1,0,SUMO specific peptidase 6,SENP6,1
+ENSG00000284024,0,0,0,0,1,0,zinc finger and SCAN domain containing 29,LOC100421372,1
+ENSG00000140990,0,0,0,0,1,0,"NADH:ubiquinone oxidoreductase subunit B10",NDUFB10,1
+ENSG00000275111,0,0,0,0,1,0,zinc finger protein 2,ZNF2,1
+ENSG00000163001,0,0,0,0,1,0,cilia and flagella associated protein 36,CFAP36,1
+ENSG00000170142,0,0,0,0,1,0,ubiquitin conjugating enzyme E2 E1,UBE2E1,1
+ENSG00000106028,0,0,0,0,1,0,single stranded DNA binding protein 1,SSBP1,1
+ENSG00000136938,0,0,0,0,1,0,acidic nuclear phosphoprotein 32 family member B,ANP32B,1
+ENSG00000154114,0,0,0,0,1,0,tubulin folding cofactor E like,TBCEL,1
+ENSG00000225663,0,0,0,0,1,0,MAPK regulated corepressor interacting protein 1,MCRIP1,1
+ENSG00000239713,0,0,0,0,1,0,apolipoprotein B mRNA editing enzyme catalytic subunit 3G,APOBEC3G,1
+ENSG00000197894,0,0,0,0,1,0,"alcohol dehydrogenase 5 (class III), chi polypeptide",ADH5,1
+ENSG00000197043,0,0,0,0,1,0,annexin A6,ANXA6,1
+ENSG00000149084,0,0,0,0,1,0,hydroxysteroid 17-beta dehydrogenase 12,HSD17B12,1
+ENSG00000243989,0,0,0,0,1,0,aminoacylase 1,ACY1,1
+ENSG00000139168,0,0,0,0,1,0,zinc finger CCHC-type and RNA binding motif containing 1,ZCRB1,1
+ENSG00000269858,0,0,0,0,1,0,egl-9 family hypoxia inducible factor 2,EGLN2,1
+ENSG00000147724,0,0,0,0,1,0,family with sequence similarity 135 member B,FAM135B,1
+ENSG00000091138,0,0,0,0,1,0,solute carrier family 26 member 3,SLC26A3,1
+ENSG00000127445,0,0,0,0,1,0,"peptidylprolyl cis/trans isomerase, NIMA-interacting 1",PIN1,1
+ENSG00000148110,0,0,0,0,1,0,major facilitator superfamily domain containing 14B,MFSD14B,1
+ENSG00000167302,0,0,0,0,1,0,TEPSIN adaptor related protein complex 4 accessory protein,TEPSIN,1
+ENSG00000161970,0,0,0,0,1,0,ribosomal protein L26,RPL26,1
+ENSG00000180198,0,0,0,0,1,0,regulator of chromosome condensation 1,RCC1,1
+ENSG00000128591,0,0,0,0,1,0,filamin C,FLNC,1
+ENSG00000180747,0,0,0,0,1,0,SMG1 pseudogene 3,SMG1P3,1
+ENSG00000197579,0,0,0,0,1,0,"TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase",TOPORS,1
+ENSG00000197265,0,0,0,0,1,0,general transcription factor IIE subunit 2,GTF2E2,1
+ENSG00000184343,0,0,0,0,1,0,SRSF protein kinase 3,SRPK3,1
+ENSG00000188089,0,0,0,0,1,0,phospholipase A2 group IVE,PLA2G4E,1
+ENSG00000138459,0,0,0,0,1,0,solute carrier family 35 member A5,SLC35A5,1
+ENSG00000168806,0,0,0,0,1,0,leucine carboxyl methyltransferase 2,LCMT2,1
+ENSG00000158428,0,0,0,0,1,0,ciliogenesis associated TTC17 interacting protein,CATIP,1
+ENSG00000106302,0,0,0,0,1,0,hyaluronidase 4,HYAL4,1
+ENSG00000230359,0,0,0,0,1,0,triosephosphate isomerase 1 pseudogene 2,TPI1P2,1
+ENSG00000118473,0,0,0,0,1,0,SH3GL interacting endocytic adaptor 1,SGIP1,1
+ENSG00000119547,0,0,0,0,1,0,one cut homeobox 2,ONECUT2,1
+ENSG00000165376,0,0,0,0,1,0,claudin 2,CLDN2,1
+ENSG00000253251,0,0,0,0,1,0,shieldin complex subunit 3,SHLD3,1
+ENSG00000105248,0,0,0,0,1,0,YJU2 splicing factor homolog,YJU2,1
+ENSG00000145506,0,0,0,0,1,0,NKD inhibitor of WNT signaling pathway 2,NKD2,1
+ENSG00000104154,0,0,0,0,1,0,solute carrier family 30 member 4,SLC30A4,1
+ENSG00000151952,0,0,0,0,1,0,transmembrane protein 132D,TMEM132D,1
+ENSG00000230601,0,0,0,0,1,0,testis expressed 48,TEX48,1
+ENSG00000030110,0,0,0,0,1,0,BCL2 antagonist/killer 1,BAK1,1
+ENSG00000166845,0,0,0,0,1,0,chromosome 18 open reading frame 54,C18orf54,1
+ENSG00000119147,0,0,0,0,1,0,ECRG4 augurin precursor,ECRG4,1
+ENSG00000227835,0,0,0,0,1,0,NA,NA,1
+ENSG00000091972,0,0,0,0,1,0,CD200 molecule,CD200,1
+ENSG00000164919,0,0,0,0,1,0,cytochrome c oxidase subunit 6C,COX6C,1
+ENSG00000144655,0,0,0,0,1,0,cysteine and serine rich nuclear protein 1,CSRNP1,1
+ENSG00000172889,0,0,0,0,1,0,EGF like domain multiple 7,EGFL7,1
+ENSG00000137133,0,0,0,0,1,0,histidine triad nucleotide binding protein 2,HINT2,1
+ENSG00000100209,0,0,0,0,1,0,HscB mitochondrial iron-sulfur cluster cochaperone,HSCB,1
+ENSG00000269335,0,0,0,0,1,0,inhibitor of nuclear factor kappa B kinase regulatory subunit gamma,IKBKG,1
+ENSG00000161677,0,0,0,0,1,0,Josephin domain containing 2,JOSD2,1
+ENSG00000128052,0,0,0,0,1,0,kinase insert domain receptor,KDR,1
+ENSG00000171444,0,0,0,0,1,0,MCC regulator of WNT signaling pathway,MCC,1
+ENSG00000119227,0,0,0,0,1,0,phosphatidylinositol glycan anchor biosynthesis class Z,PIGZ,1
+ENSG00000104886,0,0,0,0,1,0,pleckstrin homology domain containing J1,PLEKHJ1,1
+ENSG00000182872,0,0,0,0,1,0,RNA binding motif protein 10,RBM10,1
+ENSG00000114204,0,0,0,0,1,0,serpin family I member 2,SERPINI2,1
+ENSG00000107819,0,0,0,0,1,0,sideroflexin 3,SFXN3,1
+ENSG00000215347,0,0,0,0,1,0,NA,NA,1
+ENSG00000139656,0,0,0,0,1,0,small integral membrane protein 2,SMIM2,1
+ENSG00000118707,0,0,0,0,1,0,TGFB induced factor homeobox 2,TGIF2,1
+ENSG00000154096,0,0,0,0,1,0,Thy-1 cell surface antigen,THY1,1
+ENSG00000153802,0,0,0,0,1,0,transmembrane serine protease 11D,TMPRSS11D,1
+ENSG00000162191,0,0,0,0,1,0,UBX domain protein 1,UBXN1,1
+ENSG00000095397,0,0,0,0,1,0,whirlin,WHRN,1
+ENSG00000126215,0,0,0,0,1,0,X-ray repair cross complementing 3,XRCC3,1
+ENSG00000205189,0,0,0,0,1,0,zinc finger and BTB domain containing 10,ZBTB10,1
+ENSG00000284283,0,0,0,0,0,1,NA,NA,1
+ENSG00000243232,0,0,0,0,0,1,"protocadherin alpha subfamily C, 2",PCDHAC2,1
+ENSG00000262583,0,0,0,0,0,1,NA,NA,1
+ENSG00000152217,0,0,0,0,0,1,SET binding protein 1,SETBP1,1
+ENSG00000170956,0,0,0,0,0,1,CEA cell adhesion molecule 3,CEACAM3,1
+ENSG00000184349,0,0,0,0,0,1,ephrin A5,EFNA5,1
+ENSG00000254430,0,0,0,0,0,1,olfactory receptor family 6 subfamily M member 3 pseudogene,OR6M3P,1
+ENSG00000268598,0,0,0,0,0,1,vomeronasal 1 receptor 80 pseudogene,VN1R80P,1
+ENSG00000169926,0,0,0,0,0,1,Kruppel like factor 13,KLF13,1
+ENSG00000138463,0,0,0,0,0,1,solute carrier family 49 member 4,SLC49A4,1
+ENSG00000120549,0,0,0,0,0,1,KIAA1217,KIAA1217,1
+ENSG00000233609,0,0,0,0,0,1,NA,NA,1
+ENSG00000161835,0,0,0,0,0,1,trafficking regulator and scaffold protein tamalin,TAMALIN,1
+ENSG00000169727,0,0,0,0,0,1,G protein pathway suppressor 1,GPS1,1
+ENSG00000099331,0,0,0,0,0,1,myosin IXB,MYO9B,1
+ENSG00000196072,0,0,0,0,0,1,biogenesis of lysosomal organelles complex 1 subunit 2,BLOC1S2,1
+ENSG00000130522,0,0,0,0,0,1,"JunD proto-oncogene, AP-1 transcription factor subunit",JUND,1
+ENSG00000103569,0,0,0,0,0,1,aquaporin 9,AQP9,1
+ENSG00000101974,0,0,0,0,0,1,ATPase phospholipid transporting 11C,ATP11C,1
+ENSG00000103126,0,0,0,0,0,1,axin 1,AXIN1,1
+ENSG00000146540,0,0,0,0,0,1,chromosome 7 open reading frame 50,C7orf50,1
+ENSG00000167130,0,0,0,0,0,1,dolichyldiphosphatase 1,DOLPP1,1
+ENSG00000124205,0,0,0,0,0,1,endothelin 3,EDN3,1
+ENSG00000164404,0,0,0,0,0,1,growth differentiation factor 9,GDF9,1
+ENSG00000176476,0,0,0,0,0,1,SAGA complex associated factor 29,SGF29,1
+ENSG00000172716,0,0,0,0,0,1,schlafen family member 11,SLFN11,1
diff --git a/results/tables/intersect_regions_by_sex_female.xlsx b/results/tables/intersect_regions_by_sex_female.xlsx
new file mode 100644
index 0000000000000000000000000000000000000000..316c8d103e12240f914d5f95c291d0bbb85bccaf
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z4a^7pA{AxkjK6~NTQ9uHFgz>;U_1sG_<zuIay?nkO?yk=2zxCHM@LH=xP!<~|2{5k
zYH9PcXBdA)ZO0EvYd4UUI$XPAZ(*+G2z0~AKcM!r2F4%Xf_`m{_LuF`bB3aU{@ZIm
zzm)M;Vt!oLF(vX#fBvnmpA|6vRtfZDGPJ*JA8$3X0!F9){9?u*?tp&Ig!Y&1BlG{v
v53U*C<tFF`BBy=OeIGEer7_DN-9W_c9|7L1!02OO-~mE4V0x<90OA1vn~kF9

literal 0
HcmV?d00001

diff --git a/results/tables/intersect_regions_by_sex_male.csv b/results/tables/intersect_regions_by_sex_male.csv
new file mode 100644
index 0000000..248568e
--- /dev/null
+++ b/results/tables/intersect_regions_by_sex_male.csv
@@ -0,0 +1,464 @@
+gene,aINS_male,Cg25_male,dlPFC_male,Nac_male,OFC_male,Sub_male,GENENAME,SYMBOL,exclusive
+ENSG00000176956,1,0,0,0,0,1,lymphocyte antigen 6 family member H,LY6H,2
+ENSG00000178397,1,0,0,0,1,0,family with sequence similarity 220 member A,FAM220A,2
+ENSG00000133105,1,0,0,0,1,0,relaxin family peptide receptor 2,RXFP2,2
+ENSG00000112763,0,1,0,0,0,1,butyrophilin subfamily 2 member A1,BTN2A1,2
+ENSG00000214076,0,1,0,0,0,1,CPSF1 pseudogene 1,CPSF1P1,2
+ENSG00000006015,0,1,0,1,0,0,required for excision 1-B domain containing,REX1BD,2
+ENSG00000100191,0,1,0,1,0,0,solute carrier family 5 member 4,SLC5A4,2
+ENSG00000076248,0,1,0,0,0,1,uracil DNA glycosylase,UNG,2
+ENSG00000143630,0,0,1,1,0,0,hyperpolarization activated cyclic nucleotide gated potassium channel 3,HCN3,2
+ENSG00000114654,0,0,0,1,0,1,EF-hand and coiled-coil domain containing 1,EFCC1,2
+ENSG00000186350,1,0,0,0,0,0,retinoid X receptor alpha,RXRA,1
+ENSG00000151718,1,0,0,0,0,0,WW and C2 domain containing 2,WWC2,1
+ENSG00000008382,1,0,0,0,0,0,MPN domain containing,MPND,1
+ENSG00000157557,1,0,0,0,0,0,"ETS proto-oncogene 2, transcription factor",ETS2,1
+ENSG00000099364,1,0,0,0,0,0,F-box and leucine rich repeat protein 19,FBXL19,1
+ENSG00000241644,0,1,0,0,0,0,indolethylamine N-methyltransferase,INMT,1
+ENSG00000285607,0,1,0,0,0,0,NA,NA,1
+ENSG00000145779,0,1,0,0,0,0,TNF alpha induced protein 8,TNFAIP8,1
+ENSG00000104998,0,1,0,0,0,0,interleukin 27 receptor subunit alpha,IL27RA,1
+ENSG00000171792,0,1,0,0,0,0,RAD9-HUS1-RAD1 interacting nuclear orphan 1,RHNO1,1
+ENSG00000099917,0,1,0,0,0,0,mediator complex subunit 15,MED15,1
+ENSG00000237649,0,1,0,0,0,0,kinesin family member C1,KIFC1,1
+ENSG00000213569,0,1,0,0,0,0,NA,NA,1
+ENSG00000113460,0,1,0,0,0,0,biogenesis of ribosomes BRX1,BRIX1,1
+ENSG00000008323,0,1,0,0,0,0,pleckstrin homology and RhoGEF domain containing G6,PLEKHG6,1
+ENSG00000197380,0,1,0,0,0,0,dishevelled binding antagonist of beta catenin 3,DACT3,1
+ENSG00000128298,0,1,0,0,0,0,BAR/IMD domain containing adaptor protein 2 like 2,BAIAP2L2,1
+ENSG00000128000,0,1,0,0,0,0,zinc finger protein 780B,ZNF780B,1
+ENSG00000141499,0,1,0,0,0,0,WD repeat containing antisense to TP53,WRAP53,1
+ENSG00000184524,0,1,0,0,0,0,cell cycle exit and neuronal differentiation 1,CEND1,1
+ENSG00000146416,0,1,0,0,0,0,androgen induced 1,AIG1,1
+ENSG00000105143,0,1,0,0,0,0,solute carrier family 1 member 6,SLC1A6,1
+ENSG00000149925,0,1,0,0,0,0,"aldolase, fructose-bisphosphate A",ALDOA,1
+ENSG00000184897,0,1,0,0,0,0,H1.10 linker histone,H1-10,1
+ENSG00000131469,0,1,0,0,0,0,ribosomal protein L27,RPL27,1
+ENSG00000117013,0,1,0,0,0,0,potassium voltage-gated channel subfamily Q member 4,KCNQ4,1
+ENSG00000123329,0,1,0,0,0,0,Rho GTPase activating protein 9,ARHGAP9,1
+ENSG00000197121,0,1,0,0,0,0,post-GPI attachment to proteins inositol deacylase 1,PGAP1,1
+ENSG00000214274,0,1,0,0,0,0,angiogenin,ANG,1
+ENSG00000230097,0,1,0,0,0,0,NA,NA,1
+ENSG00000117425,0,1,0,0,0,0,patched 2,PTCH2,1
+ENSG00000114544,0,1,0,0,0,0,solute carrier family 41 member 3,SLC41A3,1
+ENSG00000237440,0,1,0,0,0,0,zinc finger protein 737,ZNF737,1
+ENSG00000197566,0,1,0,0,0,0,zinc finger protein 624,ZNF624,1
+ENSG00000083457,0,1,0,0,0,0,integrin subunit alpha E,ITGAE,1
+ENSG00000147604,0,1,0,0,0,0,ribosomal protein L7,RPL7,1
+ENSG00000114391,0,1,0,0,0,0,ribosomal protein L24,RPL24,1
+ENSG00000172361,0,1,0,0,0,0,cilia and flagella associated protein 53,CFAP53,1
+ENSG00000114204,0,1,0,0,0,0,serpin family I member 2,SERPINI2,1
+ENSG00000102804,0,1,0,0,0,0,TSC22 domain family member 1,TSC22D1,1
+ENSG00000174197,0,1,0,0,0,0,MAX dimerization protein MGA,MGA,1
+ENSG00000197050,0,1,0,0,0,0,zinc finger protein 420,ZNF420,1
+ENSG00000130224,0,1,0,0,0,0,leucine rich repeats and calponin homology domain containing 2,LRCH2,1
+ENSG00000167674,0,1,0,0,0,0,HDGF like 2,HDGFL2,1
+ENSG00000219507,0,1,0,0,0,0,NA,NA,1
+ENSG00000177954,0,1,0,0,0,0,ribosomal protein S27,RPS27,1
+ENSG00000180155,0,1,0,0,0,0,Ly6/neurotoxin 1,LYNX1,1
+ENSG00000147654,0,1,0,0,0,0,estrogen receptor binding site associated antigen 9,EBAG9,1
+ENSG00000198618,0,1,0,0,0,0,NA,NA,1
+ENSG00000070423,0,1,0,0,0,0,ring finger protein 126,RNF126,1
+ENSG00000163141,0,1,0,0,0,0,BCL2 interacting protein like,BNIPL,1
+ENSG00000133265,0,1,0,0,0,0,HSPA (Hsp70) binding protein 1,HSPBP1,1
+ENSG00000168453,0,1,0,0,0,0,HR lysine demethylase and nuclear receptor corepressor,HR,1
+ENSG00000205593,0,1,0,0,0,0,DENN domain containing 6B,DENND6B,1
+ENSG00000179855,0,1,0,0,0,0,GIPC PDZ domain containing family member 3,GIPC3,1
+ENSG00000176222,0,1,0,0,0,0,zinc finger protein 404,ZNF404,1
+ENSG00000132128,0,1,0,0,0,0,leucine rich repeat containing 41,LRRC41,1
+ENSG00000270800,0,1,0,0,0,0,RPS10-NUDT3 readthrough,RPS10-NUDT3,1
+ENSG00000157873,0,1,0,0,0,0,TNF receptor superfamily member 14,TNFRSF14,1
+ENSG00000154473,0,1,0,0,0,0,BUB3 mitotic checkpoint protein,BUB3,1
+ENSG00000172889,0,1,0,0,0,0,EGF like domain multiple 7,EGFL7,1
+ENSG00000138777,0,1,0,0,0,0,inorganic pyrophosphatase 2,PPA2,1
+ENSG00000198821,0,1,0,0,0,0,CD247 molecule,CD247,1
+ENSG00000115548,0,1,0,0,0,0,lysine demethylase 3A,KDM3A,1
+ENSG00000181804,0,1,0,0,0,0,solute carrier family 9 member A9,SLC9A9,1
+ENSG00000184863,0,1,0,0,0,0,RNA binding motif protein 33,RBM33,1
+ENSG00000122691,0,1,0,0,0,0,twist family bHLH transcription factor 1,TWIST1,1
+ENSG00000275048,0,1,0,0,0,0,BSND pseudogene 1,BSNDP1,1
+ENSG00000256310,0,1,0,0,0,0,NA,NA,1
+ENSG00000197748,0,1,0,0,0,0,cilia and flagella associated protein 43,CFAP43,1
+ENSG00000042753,0,1,0,0,0,0,adaptor related protein complex 2 subunit sigma 1,AP2S1,1
+ENSG00000138688,0,1,0,0,0,0,KIAA1109,KIAA1109,1
+ENSG00000118514,0,1,0,0,0,0,aldehyde dehydrogenase 8 family member A1,ALDH8A1,1
+ENSG00000013725,0,1,0,0,0,0,CD6 molecule,CD6,1
+ENSG00000168000,0,1,0,0,0,0,"BSCL2 lipid droplet biogenesis associated, seipin",BSCL2,1
+ENSG00000144278,0,1,0,0,0,0,polypeptide N-acetylgalactosaminyltransferase 13,GALNT13,1
+ENSG00000198794,0,1,0,0,0,0,secretory carrier membrane protein 5,SCAMP5,1
+ENSG00000133640,0,1,0,0,0,0,leucine rich repeats and IQ motif containing 1,LRRIQ1,1
+ENSG00000166165,0,1,0,0,0,0,creatine kinase B,CKB,1
+ENSG00000133067,0,1,0,0,0,0,leucine rich repeat containing G protein-coupled receptor 6,LGR6,1
+ENSG00000118412,0,1,0,0,0,0,caspase 8 associated protein 2,CASP8AP2,1
+ENSG00000187481,0,1,0,0,0,0,NA,NA,1
+ENSG00000139675,0,1,0,0,0,0,heterogeneous nuclear ribonucleoprotein A1 like 2,HNRNPA1L2,1
+ENSG00000215867,0,1,0,0,0,0,keratin 18 pseudogene 57,KRT18P57,1
+ENSG00000135315,0,1,0,0,0,0,centrosomal protein 162,CEP162,1
+ENSG00000065243,0,1,0,0,0,0,protein kinase N2,PKN2,1
+ENSG00000203855,0,1,0,0,0,0,NA,NA,1
+ENSG00000121989,0,1,0,0,0,0,activin A receptor type 2A,ACVR2A,1
+ENSG00000009694,0,1,0,0,0,0,teneurin transmembrane protein 1,TENM1,1
+ENSG00000177963,0,1,0,0,0,0,RIC8 guanine nucleotide exchange factor A,RIC8A,1
+ENSG00000220563,0,1,0,0,0,0,pyruvate kinase M1/2 pseudogene 3,PKMP3,1
+ENSG00000179611,0,1,0,0,0,0,diacylglycerol kinase zeta pseudogene 1,DGKZP1,1
+ENSG00000129317,0,1,0,0,0,0,pseudouridine synthase 7 like,PUS7L,1
+ENSG00000186577,0,1,0,0,0,0,small integral membrane protein 29,SMIM29,1
+ENSG00000164074,0,1,0,0,0,0,abhydrolase domain containing 18,ABHD18,1
+ENSG00000171944,0,1,0,0,0,0,olfactory receptor family 52 subfamily A member 5,OR52A5,1
+ENSG00000105223,0,1,0,0,0,0,phospholipase D family member 3,PLD3,1
+ENSG00000187416,0,1,0,0,0,0,LHFPL tetraspan subfamily member 3,LHFPL3,1
+ENSG00000168539,0,1,0,0,0,0,cholinergic receptor muscarinic 1,CHRM1,1
+ENSG00000167578,0,1,0,0,0,0,"RAB4B, member RAS oncogene family",RAB4B,1
+ENSG00000135766,0,1,0,0,0,0,egl-9 family hypoxia inducible factor 1,EGLN1,1
+ENSG00000075292,0,1,0,0,0,0,zinc finger protein 638,ZNF638,1
+ENSG00000143393,0,1,0,0,0,0,phosphatidylinositol 4-kinase beta,PI4KB,1
+ENSG00000166575,0,1,0,0,0,0,transmembrane protein 135,TMEM135,1
+ENSG00000235141,0,1,0,0,0,0,NA,NA,1
+ENSG00000267508,0,1,0,0,0,0,zinc finger protein 285,ZNF285,1
+ENSG00000172059,0,1,0,0,0,0,Kruppel like factor 11,KLF11,1
+ENSG00000149582,0,1,0,0,0,0,transmembrane protein 25,TMEM25,1
+ENSG00000181220,0,1,0,0,0,0,zinc finger protein 746,ZNF746,1
+ENSG00000071889,0,1,0,0,0,0,FAM3 metabolism regulating signaling molecule A,FAM3A,1
+ENSG00000136770,0,1,0,0,0,0,DnaJ heat shock protein family (Hsp40) member C1,DNAJC1,1
+ENSG00000153487,0,1,0,0,0,0,inhibitor of growth family member 1,ING1,1
+ENSG00000189127,0,1,0,0,0,0,ankyrin repeat domain 34B,ANKRD34B,1
+ENSG00000082805,0,1,0,0,0,0,ELKS/RAB6-interacting/CAST family member 1,ERC1,1
+ENSG00000203780,0,1,0,0,0,0,fibronectin type III and ankyrin repeat domains 1,FANK1,1
+ENSG00000115761,0,1,0,0,0,0,nucleolar protein 10,NOL10,1
+ENSG00000113356,0,1,0,0,0,0,RNA polymerase III subunit G,POLR3G,1
+ENSG00000116663,0,1,0,0,0,0,F-box protein 6,FBXO6,1
+ENSG00000196961,0,1,0,0,0,0,adaptor related protein complex 2 subunit alpha 1,AP2A1,1
+ENSG00000154479,0,1,0,0,0,0,cilia and flagella associated protein 210,CFAP210,1
+ENSG00000198478,0,1,0,0,0,0,SH3 domain binding glutamate rich protein like 2,SH3BGRL2,1
+ENSG00000236565,0,1,0,0,0,0,heterogeneous nuclear ribonucleoprotein A3 pseudogene 5,HNRNPA3P5,1
+ENSG00000172171,0,1,0,0,0,0,"transcription elongation factor, mitochondrial",TEFM,1
+ENSG00000142186,0,1,0,0,0,0,SCY1 like pseudokinase 1,SCYL1,1
+ENSG00000127580,0,1,0,0,0,0,WD repeat domain 24,WDR24,1
+ENSG00000215472,0,1,0,0,0,0,RPL17-C18orf32 readthrough,RPL17-C18orf32,1
+ENSG00000141580,0,1,0,0,0,0,WD repeat domain 45B,WDR45B,1
+ENSG00000185710,0,1,0,0,0,0,SMG1 pseudogene 4,SMG1P4,1
+ENSG00000177200,0,1,0,0,0,0,chromodomain helicase DNA binding protein 9,CHD9,1
+ENSG00000116251,0,1,0,0,0,0,ribosomal protein L22,RPL22,1
+ENSG00000138180,0,1,0,0,0,0,centrosomal protein 55,CEP55,1
+ENSG00000178015,0,1,0,0,0,0,G protein-coupled receptor 150,GPR150,1
+ENSG00000174516,0,1,0,0,0,0,pellino E3 ubiquitin protein ligase family member 3,PELI3,1
+ENSG00000170222,0,1,0,0,0,0,"ADP-ribose/CDP-alcohol diphosphatase, manganese dependent",ADPRM,1
+ENSG00000091831,0,1,0,0,0,0,estrogen receptor 1,ESR1,1
+ENSG00000180777,0,1,0,0,0,0,ankyrin repeat domain 30B,ANKRD30B,1
+ENSG00000172969,0,1,0,0,0,0,FSHD region gene 2 family member C,FRG2C,1
+ENSG00000070961,0,1,0,0,0,0,ATPase plasma membrane Ca2+ transporting 1,ATP2B1,1
+ENSG00000213047,0,1,0,0,0,0,DENN domain containing 1B,DENND1B,1
+ENSG00000109971,0,1,0,0,0,0,heat shock protein family A (Hsp70) member 8,HSPA8,1
+ENSG00000205609,0,1,0,0,0,0,eukaryotic translation initiation factor 3 subunit C like,EIF3CL,1
+ENSG00000074317,0,1,0,0,0,0,synuclein beta,SNCB,1
+ENSG00000196498,0,1,0,0,0,0,nuclear receptor corepressor 2,NCOR2,1
+ENSG00000164483,0,1,0,0,0,0,sterile alpha motif domain containing 3,SAMD3,1
+ENSG00000172809,0,1,0,0,0,0,ribosomal protein L38,RPL38,1
+ENSG00000084207,0,1,0,0,0,0,glutathione S-transferase pi 1,GSTP1,1
+ENSG00000152208,0,1,0,0,0,0,glutamate ionotropic receptor delta type subunit 2,GRID2,1
+ENSG00000153207,0,1,0,0,0,0,AT-hook containing transcription factor 1,AHCTF1,1
+ENSG00000130204,0,1,0,0,0,0,translocase of outer mitochondrial membrane 40,TOMM40,1
+ENSG00000135686,0,1,0,0,0,0,kelch like family member 36,KLHL36,1
+ENSG00000139200,0,1,0,0,0,0,PILR alpha associated neural protein,PIANP,1
+ENSG00000145826,0,1,0,0,0,0,leukocyte cell derived chemotaxin 2,LECT2,1
+ENSG00000163596,0,1,0,0,0,0,islet cell autoantigen 1 like,ICA1L,1
+ENSG00000242173,0,1,0,0,0,0,Rho GDP dissociation inhibitor gamma,ARHGDIG,1
+ENSG00000124172,0,1,0,0,0,0,ATP synthase F1 subunit epsilon,ATP5F1E,1
+ENSG00000184009,0,1,0,0,0,0,actin gamma 1,ACTG1,1
+ENSG00000140873,0,1,0,0,0,0,ADAM metallopeptidase with thrombospondin type 1 motif 18,ADAMTS18,1
+ENSG00000173567,0,1,0,0,0,0,adhesion G protein-coupled receptor F3,ADGRF3,1
+ENSG00000112414,0,1,0,0,0,0,adhesion G protein-coupled receptor G6,ADGRG6,1
+ENSG00000162618,0,1,0,0,0,0,adhesion G protein-coupled receptor L4,ADGRL4,1
+ENSG00000106624,0,1,0,0,0,0,AE binding protein 1,AEBP1,1
+ENSG00000057663,0,1,0,0,0,0,autophagy related 5,ATG5,1
+ENSG00000139044,0,1,0,0,0,0,"beta-1,4-N-acetyl-galactosaminyltransferase 3",B4GALNT3,1
+ENSG00000152611,0,1,0,0,0,0,calcyphosine like,CAPSL,1
+ENSG00000291173,0,1,0,0,0,0,NA,NA,1
+ENSG00000141570,0,1,0,0,0,0,chromobox 8,CBX8,1
+ENSG00000134057,0,1,0,0,0,0,cyclin B1,CCNB1,1
+ENSG00000107443,0,1,0,0,0,0,cyclin J,CCNJ,1
+ENSG00000116815,0,1,0,0,0,0,CD58 molecule,CD58,1
+ENSG00000166091,0,1,0,0,0,0,CKLF like MARVEL transmembrane domain containing 5,CMTM5,1
+ENSG00000102879,0,1,0,0,0,0,coronin 1A,CORO1A,1
+ENSG00000116133,0,1,0,0,0,0,24-dehydrocholesterol reductase,DHCR24,1
+ENSG00000134516,0,1,0,0,0,0,dedicator of cytokinesis 2,DOCK2,1
+ENSG00000100129,0,1,0,0,0,0,eukaryotic translation initiation factor 3 subunit L,EIF3L,1
+ENSG00000240445,0,1,0,0,0,0,forkhead box O3B,FOXO3B,1
+ENSG00000105255,0,1,0,0,0,0,fibronectin type III and SPRY domain containing 1,FSD1,1
+ENSG00000226124,0,1,0,0,0,0,formiminotransferase cyclodeaminase N-terminal like,FTCDNL1,1
+ENSG00000144591,0,1,0,0,0,0,GDP-mannose pyrophosphorylase A,GMPPA,1
+ENSG00000102241,0,1,0,0,0,0,HIV-1 Tat specific factor 1,HTATSF1,1
+ENSG00000110324,0,1,0,0,0,0,interleukin 10 receptor subunit alpha,IL10RA,1
+ENSG00000148943,0,1,0,0,0,0,"lin-7 homolog C, crumbs cell polarity complex component",LIN7C,1
+ENSG00000146006,0,1,0,0,0,0,leucine rich repeat transmembrane neuronal 2,LRRTM2,1
+ENSG00000168067,0,1,0,0,0,0,mitogen-activated protein kinase kinase kinase kinase 2,MAP4K2,1
+ENSG00000090971,0,1,0,0,0,0,N-acetyltransferase 14 (putative),"NAT14",1
+ENSG00000178685,0,1,0,0,0,0,poly(ADP-ribose) polymerase family member 10,PARP10,1
+ENSG00000174827,0,1,0,0,0,0,PDZ domain containing 1,PDZK1,1
+ENSG00000183571,0,1,0,0,0,0,pyroglutamyl-peptidase I like,PGPEP1L,1
+ENSG00000166428,0,1,0,0,0,0,phospholipase D family member 4,PLD4,1
+ENSG00000163932,0,1,0,0,0,0,protein kinase C delta,PRKCD,1
+ENSG00000204628,0,1,0,0,0,0,receptor for activated C kinase 1,RACK1,1
+ENSG00000117602,0,1,0,0,0,0,RCAN family member 3,RCAN3,1
+ENSG00000121039,0,1,0,0,0,0,retinol dehydrogenase 10,RDH10,1
+ENSG00000137275,0,1,0,0,0,0,receptor interacting serine/threonine kinase 1,RIPK1,1
+ENSG00000164610,0,1,0,0,0,0,RP9 pre-mRNA splicing factor,RP9,1
+ENSG00000149273,0,1,0,0,0,0,ribosomal protein S3,RPS3,1
+ENSG00000063015,0,1,0,0,0,0,seizure related 6 homolog,SEZ6,1
+ENSG00000167447,0,1,0,0,0,0,SMG8 nonsense mediated mRNA decay factor,SMG8,1
+ENSG00000250317,0,1,0,0,0,0,small integral membrane protein 20,SMIM20,1
+ENSG00000077312,0,1,0,0,0,0,small nuclear ribonucleoprotein polypeptide A,SNRPA,1
+ENSG00000162236,0,1,0,0,0,0,syntaxin 5,STX5,1
+ENSG00000132604,0,1,0,0,0,0,telomeric repeat binding factor 2,TERF2,1
+ENSG00000154096,0,1,0,0,0,0,Thy-1 cell surface antigen,THY1,1
+ENSG00000145107,0,1,0,0,0,0,transmembrane 4 L six family member 19,TM4SF19,1
+ENSG00000118271,0,1,0,0,0,0,transthyretin,TTR,1
+ENSG00000140367,0,1,0,0,0,0,ubiquitin conjugating enzyme E2 Q2,UBE2Q2,1
+ENSG00000167671,0,1,0,0,0,0,UBX domain protein 6,UBXN6,1
+ENSG00000111186,0,1,0,0,0,0,Wnt family member 5B,WNT5B,1
+ENSG00000198538,0,1,0,0,0,0,zinc finger protein 28,ZNF28,1
+ENSG00000170579,0,0,1,0,0,0,DLG associated protein 1,DLGAP1,1
+ENSG00000099960,0,0,1,0,0,0,solute carrier family 7 member 4,SLC7A4,1
+ENSG00000165874,0,0,1,0,0,0,shieldin complex subunit 2 pseudogene 1,SHLD2P1,1
+ENSG00000173598,0,0,1,0,0,0,nudix hydrolase 4,NUDT4,1
+ENSG00000100138,0,0,1,0,0,0,small nuclear ribonucleoprotein 13,SNU13,1
+ENSG00000141404,0,0,1,0,0,0,G protein subunit alpha L,GNAL,1
+ENSG00000152672,0,0,1,0,0,0,C-type lectin domain family 4 member F,CLEC4F,1
+ENSG00000167772,0,0,1,0,0,0,angiopoietin like 4,ANGPTL4,1
+ENSG00000185689,0,0,1,0,0,0,protein MGC87625,C6orf201,1
+ENSG00000147437,0,0,1,0,0,0,gonadotropin releasing hormone 1,GNRH1,1
+ENSG00000116962,0,0,1,0,0,0,nidogen 1,NID1,1
+ENSG00000163710,0,0,1,0,0,0,procollagen C-endopeptidase enhancer 2,PCOLCE2,1
+ENSG00000056487,0,0,1,0,0,0,PHD finger protein 21B,PHF21B,1
+ENSG00000174136,0,0,1,0,0,0,repulsive guidance molecule BMP co-receptor b,RGMB,1
+ENSG00000167550,0,0,1,0,0,0,RHEB like 1,RHEBL1,1
+ENSG00000116649,0,0,1,0,0,0,spermidine synthase,SRM,1
+ENSG00000283453,0,0,0,1,0,0,"primase 2B, pseudogene",PRIM2BP,1
+ENSG00000177051,0,0,0,1,0,0,F-box protein 46,FBXO46,1
+ENSG00000161939,0,0,0,1,0,0,RNASEK-C17orf49 readthrough,RNASEK-C17orf49,1
+ENSG00000172476,0,0,0,1,0,0,"RAB40A, member RAS oncogene family",RAB40A,1
+ENSG00000182601,0,0,0,1,0,0,heparan sulfate-glucosamine 3-sulfotransferase 4,HS3ST4,1
+ENSG00000277075,0,0,0,1,0,0,H2A clustered histone 8,H2AC8,1
+ENSG00000198658,0,0,0,1,0,0,NA,NA,1
+ENSG00000219814,0,0,0,1,0,0,ribosomal protein L23a pseudogene 47,RPL23AP47,1
+ENSG00000183807,0,0,0,1,0,0,family with sequence similarity 162 member B,FAM162B,1
+ENSG00000204287,0,0,0,1,0,0,"major histocompatibility complex, class II, DR alpha",HLA-DRA,1
+ENSG00000135114,0,0,0,1,0,0,2'-5'-oligoadenylate synthetase like,OASL,1
+ENSG00000184731,0,0,0,1,0,0,family with sequence similarity 110 member C,FAM110C,1
+ENSG00000273802,0,0,0,1,0,0,H2B clustered histone 8,H2BC8,1
+ENSG00000124208,0,0,0,1,0,0,PEDS1-UBE2V1 readthrough,PEDS1-UBE2V1,1
+ENSG00000181819,0,0,0,1,0,0,NA,NA,1
+ENSG00000221968,0,0,0,1,0,0,fatty acid desaturase 3,FADS3,1
+ENSG00000144550,0,0,0,1,0,0,copine family member 9,CPNE9,1
+ENSG00000132386,0,0,0,1,0,0,serpin family F member 1,SERPINF1,1
+ENSG00000166257,0,0,0,1,0,0,sodium voltage-gated channel beta subunit 3,SCN3B,1
+ENSG00000144868,0,0,0,1,0,0,transmembrane protein 108,TMEM108,1
+ENSG00000103245,0,0,0,1,0,0,cytosolic iron-sulfur assembly component 3,CIAO3,1
+ENSG00000162601,0,0,0,1,0,0,"Myb like, SWIRM and MPN domains 1",MYSM1,1
+ENSG00000178719,0,0,0,1,0,0,glutamate ionotropic receptor NMDA type subunit associated protein 1,GRINA,1
+ENSG00000132640,0,0,0,1,0,0,BTB domain containing 3,BTBD3,1
+ENSG00000174996,0,0,0,1,0,0,kinesin light chain 2,KLC2,1
+ENSG00000145715,0,0,0,1,0,0,RAS p21 protein activator 1,RASA1,1
+ENSG00000006283,0,0,0,1,0,0,calcium voltage-gated channel subunit alpha1 G,CACNA1G,1
+ENSG00000105711,0,0,0,1,0,0,sodium voltage-gated channel beta subunit 1,SCN1B,1
+ENSG00000157214,0,0,0,1,0,0,STEAP2 metalloreductase,STEAP2,1
+ENSG00000176697,0,0,0,1,0,0,brain derived neurotrophic factor,BDNF,1
+ENSG00000162300,0,0,0,1,0,0,zinc finger protein like 1,ZFPL1,1
+ENSG00000040608,0,0,0,1,0,0,reticulon 4 receptor,RTN4R,1
+ENSG00000179603,0,0,0,1,0,0,glutamate metabotropic receptor 8,GRM8,1
+ENSG00000162520,0,0,0,1,0,0,"syncoilin, intermediate filament protein",SYNC,1
+ENSG00000073849,0,0,0,1,0,0,"ST6 beta-galactoside alpha-2,6-sialyltransferase 1",ST6GAL1,1
+ENSG00000116991,0,0,0,1,0,0,signal induced proliferation associated 1 like 2,SIPA1L2,1
+ENSG00000165804,0,0,0,1,0,0,zinc finger protein 219,ZNF219,1
+ENSG00000205221,0,0,0,1,0,0,vitrin,VIT,1
+ENSG00000121064,0,0,0,1,0,0,serine carboxypeptidase 1,SCPEP1,1
+ENSG00000164294,0,0,0,1,0,0,glutathione peroxidase 8 (putative),GPX8,1
+ENSG00000105204,0,0,0,1,0,0,dual specificity tyrosine phosphorylation regulated kinase 1B,DYRK1B,1
+ENSG00000166558,0,0,0,1,0,0,solute carrier family 38 member 8,SLC38A8,1
+ENSG00000156097,0,0,0,1,0,0,G protein-coupled receptor 61,GPR61,1
+ENSG00000125656,0,0,0,1,0,0,caseinolytic mitochondrial matrix peptidase proteolytic subunit,CLPP,1
+ENSG00000176383,0,0,0,1,0,0,"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4",B3GNT4,1
+ENSG00000106689,0,0,0,1,0,0,LIM homeobox 2,LHX2,1
+ENSG00000203734,0,0,0,1,0,0,epithelial cell transforming 2 like,ECT2L,1
+ENSG00000153395,0,0,0,1,0,0,lysophosphatidylcholine acyltransferase 1,LPCAT1,1
+ENSG00000108219,0,0,0,1,0,0,tetraspanin 14,TSPAN14,1
+ENSG00000230601,0,0,0,1,0,0,testis expressed 48,TEX48,1
+ENSG00000143093,0,0,0,1,0,0,striatin interacting protein 1,STRIP1,1
+ENSG00000159110,0,0,0,1,0,0,interferon alpha and beta receptor subunit 2,IFNAR2,1
+ENSG00000143740,0,0,0,1,0,0,synaptosome associated protein 47,SNAP47,1
+ENSG00000117632,0,0,0,1,0,0,stathmin 1,STMN1,1
+ENSG00000277161,0,0,0,1,0,0,phosphatidylinositol glycan anchor biosynthesis class W,PIGW,1
+ENSG00000104341,0,0,0,1,0,0,lysosomal protein transmembrane 4 beta,LAPTM4B,1
+ENSG00000147457,0,0,0,1,0,0,charged multivesicular body protein 7,CHMP7,1
+ENSG00000148832,0,0,0,1,0,0,polyamine oxidase,PAOX,1
+ENSG00000265366,0,0,0,1,0,0,glutamate dehydrogenase 1 pseudogene 2,GLUD1P2,1
+ENSG00000178404,0,0,0,1,0,0,CEP295 N-terminal like,CEP295NL,1
+ENSG00000104976,0,0,0,1,0,0,small nuclear RNA activating complex polypeptide 2,SNAPC2,1
+ENSG00000238227,0,0,0,1,0,0,transmembrane protein 250,TMEM250,1
+ENSG00000198483,0,0,0,1,0,0,ankyrin repeat domain 35,ANKRD35,1
+ENSG00000106236,0,0,0,1,0,0,neuronal pentraxin 2,NPTX2,1
+ENSG00000160949,0,0,0,1,0,0,"tonsoku like, DNA repair protein",TONSL,1
+ENSG00000101333,0,0,0,1,0,0,phospholipase C beta 4,PLCB4,1
+ENSG00000248477,0,0,0,1,0,0,"NAIP pseudogene 3","NAIPP3",1
+ENSG00000250687,0,0,0,1,0,0,NA,NA,1
+ENSG00000008300,0,0,0,1,0,0,cadherin EGF LAG seven-pass G-type receptor 3,CELSR3,1
+ENSG00000185885,0,0,0,1,0,0,interferon induced transmembrane protein 1,IFITM1,1
+ENSG00000073150,0,0,0,1,0,0,pannexin 2,PANX2,1
+ENSG00000225973,0,0,0,1,0,0,PIGB opposite strand 1,PIGBOS1,1
+ENSG00000145757,0,0,0,1,0,0,spermatogenesis associated 9,SPATA9,1
+ENSG00000061492,0,0,0,1,0,0,Wnt family member 8A,WNT8A,1
+ENSG00000118972,0,0,0,0,1,0,fibroblast growth factor 23,FGF23,1
+ENSG00000149532,0,0,0,0,1,0,cleavage and polyadenylation specific factor 7,CPSF7,1
+ENSG00000134884,0,0,0,0,1,0,arginine and glutamate rich 1,ARGLU1,1
+ENSG00000188878,0,0,0,0,1,0,Fas binding factor 1,FBF1,1
+ENSG00000217128,0,0,0,0,1,0,folliculin interacting protein 1,FNIP1,1
+ENSG00000137411,0,0,0,0,1,0,"valyl-tRNA synthetase 2, mitochondrial",VARS2,1
+ENSG00000163016,0,0,0,0,1,0,ALMS1 pseudogene 1,ALMS1P1,1
+ENSG00000154358,0,0,0,0,1,0,"obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF",OBSCN,1
+ENSG00000188343,0,0,0,0,1,0,CBY1 interacting BAR domain containing 1,CIBAR1,1
+ENSG00000117153,0,0,0,0,1,0,kelch like family member 12,KLHL12,1
+ENSG00000104883,0,0,0,0,1,0,peroxisomal biogenesis factor 11 gamma,PEX11G,1
+ENSG00000239887,0,0,0,0,1,0,chromosome 1 open reading frame 226,C1orf226,1
+ENSG00000188089,0,0,0,0,1,0,phospholipase A2 group IVE,PLA2G4E,1
+ENSG00000174292,0,0,0,0,1,0,tyrosine kinase non receptor 1,TNK1,1
+ENSG00000159247,0,0,0,0,1,0,NA,NA,1
+ENSG00000185803,0,0,0,0,1,0,solute carrier family 52 member 2,SLC52A2,1
+ENSG00000140835,0,0,0,0,1,0,carbohydrate sulfotransferase 4,CHST4,1
+ENSG00000100601,0,0,0,0,1,0,"alkB homolog 1, histone H2A dioxygenase",ALKBH1,1
+ENSG00000215217,0,0,0,0,1,0,chromosome 5 open reading frame 49,C5orf49,1
+ENSG00000103326,0,0,0,0,1,0,calpain 15,CAPN15,1
+ENSG00000105479,0,0,0,0,1,0,outer dynein arm docking complex subunit 1,ODAD1,1
+ENSG00000248698,0,0,0,0,1,0,long intergenic non-protein coding RNA 1085,LINC01085,1
+ENSG00000125841,0,0,0,0,1,0,neurensin 2,NRSN2,1
+ENSG00000100300,0,0,0,0,1,0,translocator protein,TSPO,1
+ENSG00000128564,0,0,0,0,1,0,VGF nerve growth factor inducible,VGF,1
+ENSG00000160685,0,0,0,0,1,0,zinc finger and BTB domain containing 7B,ZBTB7B,1
+ENSG00000155511,0,0,0,0,0,1,glutamate ionotropic receptor AMPA type subunit 1,GRIA1,1
+ENSG00000183665,0,0,0,0,0,1,tRNA methyltransferase 12 homolog,TRMT12,1
+ENSG00000053438,0,0,0,0,0,1,neuronatin,NNAT,1
+ENSG00000185149,0,0,0,0,0,1,neuropeptide Y receptor Y2,NPY2R,1
+ENSG00000183287,0,0,0,0,0,1,collagen and calcium binding EGF domains 1,CCBE1,1
+ENSG00000119698,0,0,0,0,0,1,protein phosphatase 4 regulatory subunit 4,PPP4R4,1
+ENSG00000106069,0,0,0,0,0,1,chimerin 2,CHN2,1
+ENSG00000178163,0,0,0,0,0,1,zinc finger protein 518B,ZNF518B,1
+ENSG00000089847,0,0,0,0,0,1,ankyrin repeat domain 24,ANKRD24,1
+ENSG00000198046,0,0,0,0,0,1,zinc finger protein 667,ZNF667,1
+ENSG00000147041,0,0,0,0,0,1,synaptotagmin like 5,SYTL5,1
+ENSG00000220804,0,0,0,0,0,1,NA,NA,1
+ENSG00000128573,0,0,0,0,0,1,forkhead box P2,FOXP2,1
+ENSG00000185052,0,0,0,0,0,1,solute carrier family 24 member 3,SLC24A3,1
+ENSG00000211896,0,0,0,0,0,1,immunoglobulin heavy constant gamma 1 (G1m marker),IGHG1,1
+ENSG00000156140,0,0,0,0,0,1,ADAM metallopeptidase with thrombospondin type 1 motif 3,ADAMTS3,1
+ENSG00000215388,0,0,0,0,0,1,NA,NA,1
+ENSG00000146386,0,0,0,0,0,1,ABRA C-terminal like,ABRACL,1
+ENSG00000198563,0,0,0,0,0,1,DExD-box helicase 39B,DDX39B,1
+ENSG00000163491,0,0,0,0,0,1,NIMA related kinase 10,NEK10,1
+ENSG00000168538,0,0,0,0,0,1,trafficking protein particle complex subunit 11,TRAPPC11,1
+ENSG00000105518,0,0,0,0,0,1,transmembrane protein 205,TMEM205,1
+ENSG00000109689,0,0,0,0,0,1,stromal interaction molecule 2,STIM2,1
+ENSG00000068366,0,0,0,0,0,1,acyl-CoA synthetase long chain family member 4,ACSL4,1
+ENSG00000162066,0,0,0,0,0,1,amidohydrolase domain containing 2,AMDHD2,1
+ENSG00000028839,0,0,0,0,0,1,TATA-box binding protein like 1,TBPL1,1
+ENSG00000263142,0,0,0,0,0,1,"leucine rich repeat containing 37 member A17, pseudogene",LRRC37A17P,1
+ENSG00000119401,0,0,0,0,0,1,tripartite motif containing 32,TRIM32,1
+ENSG00000147400,0,0,0,0,0,1,centrin 2,CETN2,1
+ENSG00000181467,0,0,0,0,0,1,"RAP2B, member of RAS oncogene family",RAP2B,1
+ENSG00000151490,0,0,0,0,0,1,protein tyrosine phosphatase receptor type O,PTPRO,1
+ENSG00000162437,0,0,0,0,0,1,"ribonucleoprotein, PTB binding 2",RAVER2,1
+ENSG00000103047,0,0,0,0,0,1,transport and golgi organization 6 homolog,TANGO6,1
+ENSG00000130347,0,0,0,0,0,1,reticulon 4 interacting protein 1,RTN4IP1,1
+ENSG00000159685,0,0,0,0,0,1,coiled-coil-helix-coiled-coil-helix domain containing 6,CHCHD6,1
+ENSG00000136986,0,0,0,0,0,1,derlin 1,DERL1,1
+ENSG00000109466,0,0,0,0,0,1,kelch like family member 2,KLHL2,1
+ENSG00000175182,0,0,0,0,0,1,family with sequence similarity 131 member A,FAM131A,1
+ENSG00000059758,0,0,0,0,0,1,cyclin dependent kinase 17,CDK17,1
+ENSG00000140623,0,0,0,0,0,1,septin 12,SEPTIN12,1
+ENSG00000184307,0,0,0,0,0,1,zinc finger DHHC-type palmitoyltransferase 23,ZDHHC23,1
+ENSG00000154654,0,0,0,0,0,1,neural cell adhesion molecule 2,NCAM2,1
+ENSG00000115091,0,0,0,0,0,1,actin related protein 3,ACTR3,1
+ENSG00000163468,0,0,0,0,0,1,chaperonin containing TCP1 subunit 3,CCT3,1
+ENSG00000008083,0,0,0,0,0,1,jumonji and AT-rich interaction domain containing 2,JARID2,1
+ENSG00000164603,0,0,0,0,0,1,base methyltransferase of 25S rRNA 2 homolog,BMT2,1
+ENSG00000117069,0,0,0,0,0,1,"ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5",ST6GALNAC5,1
+ENSG00000239649,0,0,0,0,0,1,myeloid associated differentiation marker like (pseudogene),MYADML,1
+ENSG00000156414,0,0,0,0,0,1,tudor domain containing 9,TDRD9,1
+ENSG00000102078,0,0,0,0,0,1,solute carrier family 25 member 14,SLC25A14,1
+ENSG00000156261,0,0,0,0,0,1,chaperonin containing TCP1 subunit 8,CCT8,1
+ENSG00000174684,0,0,0,0,0,1,"beta-1,4-glucuronyltransferase 1",B4GAT1,1
+ENSG00000271207,0,0,0,0,0,1,MT-CO1 pseudogene 22,MTCO1P22,1
+ENSG00000131747,0,0,0,0,0,1,DNA topoisomerase II alpha,TOP2A,1
+ENSG00000219294,0,0,0,0,0,1,NA,NA,1
+ENSG00000198185,0,0,0,0,0,1,zinc finger protein 334,ZNF334,1
+ENSG00000071127,0,0,0,0,0,1,WD repeat domain 1,WDR1,1
+ENSG00000197859,0,0,0,0,0,1,ADAMTS like 2,ADAMTSL2,1
+ENSG00000105173,0,0,0,0,0,1,cyclin E1,CCNE1,1
+ENSG00000250982,0,0,0,0,0,1,NA,NA,1
+ENSG00000011009,0,0,0,0,0,1,lysophospholipase 2,LYPLA2,1
+ENSG00000047249,0,0,0,0,0,1,ATPase H+ transporting V1 subunit H,ATP6V1H,1
+ENSG00000121073,0,0,0,0,0,1,solute carrier family 35 member B1,SLC35B1,1
+ENSG00000157211,0,0,0,0,0,1,CUB domain containing protein 2,CDCP2,1
+ENSG00000213816,0,0,0,0,0,1,NA,NA,1
+ENSG00000102753,0,0,0,0,0,1,karyopherin subunit alpha 3,KPNA3,1
+ENSG00000170881,0,0,0,0,0,1,ring finger protein 139,RNF139,1
+ENSG00000117477,0,0,0,0,0,1,coiled-coil domain containing 181,CCDC181,1
+ENSG00000229184,0,0,0,0,0,1,ATP synthase peripheral stalk subunit d pseudogene 2,ATP5PDP2,1
+ENSG00000145050,0,0,0,0,0,1,mesencephalic astrocyte derived neurotrophic factor,MANF,1
+ENSG00000128595,0,0,0,0,0,1,calumenin,CALU,1
+ENSG00000206145,0,0,0,0,0,1,NA,NA,1
+ENSG00000242114,0,0,0,0,0,1,mitochondrial fission process 1,MTFP1,1
+ENSG00000160087,0,0,0,0,0,1,ubiquitin conjugating enzyme E2 J2,UBE2J2,1
+ENSG00000169976,0,0,0,0,0,1,splicing factor 3b subunit 5,SF3B5,1
+ENSG00000079689,0,0,0,0,0,1,"secretagogin, EF-hand calcium binding protein",SCGN,1
+ENSG00000242372,0,0,0,0,0,1,eukaryotic translation initiation factor 6,EIF6,1
+ENSG00000168036,0,0,0,0,0,1,catenin beta 1,CTNNB1,1
+ENSG00000270326,0,0,0,0,0,1,NA,NA,1
+ENSG00000133872,0,0,0,0,0,1,store-operated calcium entry associated regulatory factor,SARAF,1
+ENSG00000108256,0,0,0,0,0,1,nuclear FMR1 interacting protein 2,NUFIP2,1
+ENSG00000164080,0,0,0,0,0,1,RAD54 like 2,RAD54L2,1
+ENSG00000259330,0,0,0,0,0,1,InaF motif containing 2,INAFM2,1
+ENSG00000165905,0,0,0,0,0,1,LARGE xylosyl- and glucuronyltransferase 2,LARGE2,1
+ENSG00000277883,0,0,0,0,0,1,NA,NA,1
+ENSG00000117543,0,0,0,0,0,1,diphthamide biosynthesis 5,DPH5,1
+ENSG00000185272,0,0,0,0,0,1,RNA binding motif protein 11,RBM11,1
+ENSG00000189369,0,0,0,0,0,1,G1 to S phase transition 2,GSPT2,1
+ENSG00000114480,0,0,0,0,0,1,"1,4-alpha-glucan branching enzyme 1",GBE1,1
+ENSG00000154262,0,0,0,0,0,1,ATP binding cassette subfamily A member 6,ABCA6,1
+ENSG00000160973,0,0,0,0,0,1,forkhead box H1,FOXH1,1
+ENSG00000185187,0,0,0,0,0,1,single Ig and TIR domain containing,SIGIRR,1
+ENSG00000174567,0,0,0,0,0,1,golgi transport 1A,GOLT1A,1
+ENSG00000161960,0,0,0,0,0,1,eukaryotic translation initiation factor 4A1,EIF4A1,1
+ENSG00000108641,0,0,0,0,0,1,B9 domain containing 1,B9D1,1
+ENSG00000065183,0,0,0,0,0,1,WD repeat domain 3,WDR3,1
+ENSG00000189045,0,0,0,0,0,1,ankyrin repeat and death domain containing 1B,ANKDD1B,1
+ENSG00000059769,0,0,0,0,0,1,DnaJ heat shock protein family (Hsp40) member C25,DNAJC25,1
+ENSG00000163630,0,0,0,0,0,1,synaptoporin,SYNPR,1
+ENSG00000132463,0,0,0,0,0,1,G-rich RNA sequence binding factor 1,GRSF1,1
+ENSG00000116906,0,0,0,0,0,1,glyceronephosphate O-acyltransferase,GNPAT,1
+ENSG00000089169,0,0,0,0,0,1,rabphilin 3A,RPH3A,1
+ENSG00000125870,0,0,0,0,0,1,small nuclear ribonucleoprotein polypeptide B2,SNRPB2,1
+ENSG00000253729,0,0,0,0,0,1,"protein kinase, DNA-activated, catalytic subunit",PRKDC,1
+ENSG00000123496,0,0,0,0,0,1,interleukin 13 receptor subunit alpha 2,IL13RA2,1
+ENSG00000169282,0,0,0,0,0,1,potassium voltage-gated channel subfamily A regulatory beta subunit 1,KCNAB1,1
+ENSG00000165688,0,0,0,0,0,1,"peptidase, mitochondrial processing subunit alpha",PMPCA,1
+ENSG00000166128,0,0,0,0,0,1,"RAB8B, member RAS oncogene family",RAB8B,1
+ENSG00000274286,0,0,0,0,0,1,adrenoceptor alpha 2B,ADRA2B,1
+ENSG00000090097,0,0,0,0,0,1,poly(rC) binding protein 4,PCBP4,1
+ENSG00000145526,0,0,0,0,0,1,cadherin 18,CDH18,1
+ENSG00000141013,0,0,0,0,0,1,growth arrest specific 8,GAS8,1
+ENSG00000099331,0,0,0,0,0,1,myosin IXB,MYO9B,1
+ENSG00000221882,0,0,0,0,0,1,olfactory receptor family 3 subfamily A member 2,OR3A2,1
+ENSG00000143156,0,0,0,0,0,1,NME/NM23 family member 7,NME7,1
+ENSG00000164099,0,0,0,0,0,1,serine protease 12,PRSS12,1
+ENSG00000120500,0,0,0,0,0,1,arrestin 3,ARR3,1
+ENSG00000057294,0,0,0,0,0,1,plakophilin 2,PKP2,1
+ENSG00000144668,0,0,0,0,0,1,integrin subunit alpha 9,ITGA9,1
+ENSG00000186204,0,0,0,0,0,1,cytochrome P450 family 4 subfamily F member 12,CYP4F12,1
+ENSG00000115649,0,0,0,0,0,1,cyclin Pas1/PHO80 domain containing 1,CNPPD1,1
+ENSG00000184887,0,0,0,0,0,1,BTB domain containing 6,BTBD6,1
+ENSG00000177627,0,0,0,0,0,1,chromosome 12 open reading frame 54,C12orf54,1
+ENSG00000221986,0,0,0,0,0,1,myosin binding protein H like,MYBPHL,1
+ENSG00000227152,0,0,0,0,0,1,olfactory receptor family 2 subfamily T member 7,OR2T7,1
+ENSG00000205220,0,0,0,0,0,1,proteasome 20S subunit beta 10,PSMB10,1
+ENSG00000165480,0,0,0,0,0,1,spindle and kinetochore associated complex subunit 3,SKA3,1
+ENSG00000095970,0,0,0,0,0,1,triggering receptor expressed on myeloid cells 2,TREM2,1
+ENSG00000170703,0,0,0,0,0,1,tubulin tyrosine ligase like 6,TTLL6,1
diff --git a/results/tables/intersect_regions_by_sex_male.xlsx b/results/tables/intersect_regions_by_sex_male.xlsx
new file mode 100644
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diff --git a/results/tables/mdd_filtered.csv b/results/tables/mdd_filtered.csv
new file mode 100644
index 0000000..744c58f
--- /dev/null
+++ b/results/tables/mdd_filtered.csv
@@ -0,0 +1,52 @@
+,study_id,pubmed_id,publication_date,publication,title,author_fullname,author_orcid
+1,GCST90101808,35347114,2022-03-26,Transl Psychiatry,Genetics of age-at-onset in major depression.,Harder A,NA
+2,GCST90104443,35330412,2022-03-06,J Pers Med,Multi-Omics Characterization of Early- and Adult-Onset Major Depressive Disorder.,Grant CW,0000-0001-9342-2138
+3,GCST90104444,35330412,2022-03-06,J Pers Med,Multi-Omics Characterization of Early- and Adult-Onset Major Depressive Disorder.,Grant CW,0000-0001-9342-2138
+5,GCST005907,29728651,2018-04-27,Neuropsychopharmacology,"Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.",Li X,NA
+6,GCST005231,29317602,2018-01-10,Transl Psychiatry,Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.,Hall LS,0000-0002-0624-5303
+7,GCST005691,29495898,2018-03-02,Am J Psychiatry,Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.,Peterson RE,NA
+13,GCST009979,31969693,2020-01-23,Mol Psychiatry,Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.,Coleman JRI,NA
+15,GCST005230,29317602,2018-01-10,Transl Psychiatry,Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.,Hall LS,0000-0002-0624-5303
+17,GCST90058036,34586374,2021-09-29,JAMA Psychiatry,The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.,Giannakopoulou O,NA
+18,GCST005839,29700475,2018-04-26,Nat Genet,Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.,Wray NR,0000-0001-7421-3357
+20,GCST007342,30718901,2019-02-04,Nat Neurosci,Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.,Howard DM,0000-0002-6005-1972
+22,GCST010016,32231276,2020-03-30,Nat Genet,Minimal phenotyping yields genome-wide association signals of low specificity for major depression.,Cai N,0000-0001-7496-2075
+26,GCST90058033,34586374,2021-09-29,JAMA Psychiatry,The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.,Giannakopoulou O,NA
+27,GCST90058034,34586374,2021-09-29,JAMA Psychiatry,The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.,Giannakopoulou O,NA
+28,GCST90058037,34586374,2021-09-29,JAMA Psychiatry,The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.,Giannakopoulou O,NA
+38,GCST90058032,34586374,2021-09-29,JAMA Psychiatry,The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.,Giannakopoulou O,NA
+39,GCST90239706,34924174,2021-11-02,Biol Psychiatry,The Australian Genetics of Depression Study: New Risk Loci and Dissecting Heterogeneity Between Subtypes.,Mitchell BL,NA
+40,GCST90255679,36685848,2023-01-04,Front Genet,"GWAS of depression in 4,520 individuals from the Russian population highlights the role of <i>MAGI2</i> (<i>S-SCAM</i>) in the gut-brain axis.",Pinakhina D,NA
+42,GCST005902,29662059,2018-04-16,Nat Commun,Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.,Howard DM,0000-0002-6005-1972
+43,GCST005904,29662059,2018-04-16,Nat Commun,Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.,Howard DM,0000-0002-6005-1972
+44,GCST005903,29662059,2018-04-16,Nat Commun,Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.,Howard DM,0000-0002-6005-1972
+45,GCST005690,29495898,2018-03-02,Am J Psychiatry,Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.,Peterson RE,NA
+46,GCST005689,29495898,2018-03-02,Am J Psychiatry,Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.,Peterson RE,NA
+82,GCST90014430,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+83,GCST90014434,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+84,GCST90014432,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+85,GCST90014426,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+86,GCST90014428,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+87,GCST90014431,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+88,GCST90014435,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+89,GCST90014433,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+90,GCST90014427,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+91,GCST90014429,33541459,2021-02-05,BJPsych Open,Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.,Glanville KP,0000-0001-8321-9435
+164,GCST90096931,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+165,GCST90096932,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+166,GCST90096934,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+167,GCST90096935,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+168,GCST90096937,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+169,GCST90096938,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+170,GCST90096940,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+171,GCST90096941,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+172,GCST90096943,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+173,GCST90096944,34782712,2021-11-15,Mol Psychiatry,Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.,Thalamuthu A,NA
+226,GCST90058035,34586374,2021-09-29,JAMA Psychiatry,The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.,Giannakopoulou O,NA
+231,GCST90244040,35730328,2022-06-22,Eur Psychiatry,Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression.,Cheng B,NA
+232,GCST90244041,35730328,2022-06-22,Eur Psychiatry,Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression.,Cheng B,NA
+233,GCST90244042,35730328,2022-06-22,Eur Psychiatry,Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression.,Cheng B,NA
+234,GCST90244043,35730328,2022-06-22,Eur Psychiatry,Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression.,Cheng B,NA
+245,GCST012090,33479212,2021-01-21,Transl Psychiatry,Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.,Yao X,NA
+248,GCST012088,33479212,2021-01-21,Transl Psychiatry,Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.,Yao X,NA
+249,GCST012094,33483693,2021-01-22,Mol Psychiatry,Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy.,Clements CC,0000-0003-2278-6465
diff --git a/results/tables/number_of_samples.xlsx b/results/tables/number_of_samples.xlsx
new file mode 100644
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diff --git a/results/tx_enrich/go_terms.csv b/results/tx_enrich/go_terms.csv
new file mode 100644
index 0000000..ddc0a4d
--- /dev/null
+++ b/results/tx_enrich/go_terms.csv
@@ -0,0 +1,22 @@
+ID,Description,GeneRatio,BgRatio,pvalue,p.adjust,qvalue,geneID,Count,group
+GO:0030858,positive regulation of epithelial cell differentiation,3/25,64/18723,8.30298595424994e-5,0.04799125881556465,3.75e-02,PRKCH/NME2/PROM1,3,aINS_female
+GO:0002181,cytoplasmic translation,9/172,148/18723,9.284720354690927e-6,0.022459738537997355,2.17e-02,RPL27/RPL7/RPL24/RPS27/RPL22/EIF3CL/RPL38/EIF3L/RPS3,9,Cg25_male
+GO:0002181,cytoplasmic translation,20/354,148/18723,6.034935546363268e-12,1.8702265258179768e-8,1.78e-08,RPL36A/RPL27/RPS19/RPL39/RPS10/UNK/RPS15A/RPL18/EIF3A/RPL23/RPL10/RPS7/RPS14/RPS23/RPL3/RPS27A/EIF3G/RPL7A/RPL13A/RPL26,20,OFC_female
+GO:0000377,"RNA splicing, via transesterification reactions with bulged adenosine as nucleophile",21/354,320/18723,8.527948419500151e-7,7.696906681208437e-4,7.33e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
+GO:0000398,"mRNA splicing, via spliceosome",21/354,320/18723,8.527948419500151e-7,7.696906681208437e-4,7.33e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
+GO:0000375,"RNA splicing, via transesterification reactions",21/354,324/18723,1.0422977974782387e-6,7.696906681208437e-4,7.33e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
+GO:0022900,electron transport chain,15/354,175/18723,1.2418371541155916e-6,7.696906681208437e-4,7.33e-04,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/GBA/COX7B2/CHCHD2/GSR/PARK7/SDHB/NDUFB10/ADH5/COX6C,15,OFC_female
+GO:0022904,respiratory electron transport chain,12/354,114/18723,1.698069370239057e-6,8.770528297284729e-4,8.35e-04,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/GBA/CHCHD2/PARK7/SDHB/NDUFB10/COX6C,12,OFC_female
+GO:0009060,aerobic respiration,15/354,189/18723,3.252170243494876e-6,0.0014397822263700888,1.37e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/NNT/COX7B2/CHCHD2/PARK7/PDHB/SDHB/NDUFB10/COX6C,15,OFC_female
+GO:0045333,cellular respiration,16/354,230/18723,8.390432950595276e-6,0.0032502439642368448,3.09e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/NNT/GBA/COX7B2/CHCHD2/PARK7/PDHB/SDHB/NDUFB10/COX6C,16,OFC_female
+GO:0008380,RNA splicing,23/354,434/18723,9.56260978898458e-6,0.003292725304007024,3.13e-03,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/CTNNBL1/DDX39B/HNRNPM/FUS/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,23,OFC_female
+GO:0042773,ATP synthesis coupled electron transport,10/354,95/18723,1.2495335857215579e-5,0.003520276892864644,3.35e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/CHCHD2/PARK7/NDUFB10/COX6C,10,OFC_female
+GO:0042775,mitochondrial ATP synthesis coupled electron transport,10/354,95/18723,1.2495335857215579e-5,0.003520276892864644,3.35e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/CHCHD2/PARK7/NDUFB10/COX6C,10,OFC_female
+GO:0006119,oxidative phosphorylation,12/354,141/18723,1.5525975786513112e-5,0.004009583246867011,3.82e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/COX7B2/CHCHD2/PARK7/NDUFB10/COX6C,12,OFC_female
+GO:0022618,ribonucleoprotein complex assembly,15/354,220/18723,2.0326057552656432e-5,0.0048454194119755606,4.61e-03,RPS19/SART1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL13A/SRPK3/YJU2,15,OFC_female
+GO:0022613,ribonucleoprotein complex biogenesis,23/354,463/18723,2.6717121336838507e-5,0.0059140256444901815,5.63e-03,RPL27/RPS19/NOP56/SART1/NOLC1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS7/RPP40/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL7A/C1QBP/RPL13A/RPL26/SRPK3/YJU2,23,OFC_female
+GO:0071826,ribonucleoprotein complex subunit organization,15/354,227/18723,2.9313781484128114e-5,0.006056227254620868,5.76e-03,RPS19/SART1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL13A/SRPK3/YJU2,15,OFC_female
+GO:1903311,regulation of mRNA metabolic process,17/354,288/18723,3.71319720449354e-5,0.0071281511815515786,6.78e-03,SUPT5H/HNRNPA1/LARP1/NCL/SF1/RNPS1/POLR2G/TENT4A/HNRNPM/NBAS/SAFB/FUS/TNRC6B/C1QBP/TBRG4/SRPK3/RBM10,17,OFC_female
+GO:0019646,aerobic electron transport chain,9/354,87/18723,3.910247501980537e-5,0.0071281511815515786,6.78e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/PARK7/NDUFB10/COX6C,9,OFC_female
+GO:2001252,positive regulation of chromosome organization,8/354,82/18723,1.5920489566435716e-4,0.027409776203546822,2.61e-02,HNRNPA2B1/HNRNPA1/DNMT1/SFPQ/SETDB1/GTF2H2/SSBP1/SLX1A,8,OFC_female
+GO:1902253,regulation of intrinsic apoptotic signaling pathway by p53 class mediator,5/354,29/18723,1.9198597909498622e-4,0.031313923642913806,2.98e-02,MARCHF7/ARMC10/UBB/RPS7/RPL26,5,OFC_female
diff --git a/scripts/edger_diff_gene.R b/scripts/edger_diff_gene.R
index 529a3db..00ea839 100644
--- a/scripts/edger_diff_gene.R
+++ b/scripts/edger_diff_gene.R
@@ -34,6 +34,11 @@ y <- scaleOffset(y, norm_mat)
 design <- model.matrix(~ 0 + ph + rin + group, data = ann)
 colnames(design)[3:ncol(design)] <- gsub("group", "", colnames(design)[3:ncol(design)])
 
+# design <- model.matrix(~ 0 + ph + rin + region:phenotype:gender, data = ann)
+# colnames(design)[3:ncol(design)] <- sapply(strsplit(colnames(design)[3:ncol(design)], ":"), function(x) {
+#   paste(gsub("region", "", x[1]), gsub("phenotype", "", x[2]), gsub("gender", "", x[3]), sep = "_")
+# })
+
 ct <- makeContrasts(
   aINS_female = aINS_MDD_female-aINS_CTRL_female,
   aINS_male = aINS_MDD_male-aINS_CTRL_male,
@@ -50,17 +55,17 @@ ct <- makeContrasts(
   levels = design
 )
 
-# Filter low expression genes
+# Filter genes of low expression
 keep <- filterByExpr(y, group = y$samples$group)
 y <- y[keep,]
 
 # TMM normalization
-y <- calcNormFactors(y)
+# y <- calcNormFactors(y)
 
-# Estimate dispersions with  
+# Estimate dispersions with 'estimateGLMRobustDisp'
 y <- estimateGLMRobustDisp(y, design = design, verbose = T)
 
-# Fit
+# Fit model
 fit <- glmFit(y, design = design)
 
 # Extract results for each comparison
@@ -68,7 +73,7 @@ fit <- glmFit(y, design = design)
 # Summary dataframe
 map_df(comp, function(c) {
   
-  cat("Comparison: ", c)
+  cat("Comparison: ", c, )
   
   lrt <- glmLRT(fit, contrast = ct[, c])
   df <- topTags(lrt, n = Inf, adjust.method = "BH", p.value = 0.05)$table
diff --git a/scripts/gwas_intersections.R b/scripts/gwas_intersections.R
index 88c651b..91c9733 100644
--- a/scripts/gwas_intersections.R
+++ b/scripts/gwas_intersections.R
@@ -1,38 +1,82 @@
+
+# GWAS risk variants ------------------------------------------------------
+
 library(dplyr)
-library(readr)
-library(gwasrapidd)
+library(purrr)
 
-load("results/diff_exp/diff_df.rda")
+# Get studies related to 'major depressive disorder' and 'unipolar depression'.
+efo_id <- c(
+  unipolar_depression        = "EFO_0003761",
+  major_depressive_disorder  = "MONDO_0002009"
+)
+mdd_results <- get_studies(efo_id = efo_id, set_operation = "intersection") 
+
+mdd_filtered <- mdd_results@publications %>% 
+  filter(publication_date > "2018-01-01")
+
+# From the results above, we manually removed studies that involved different themes,
+# such as other psychiatric conditions. The results are shown in 'mdd_filtered.csv'
+mdd_filtered <- read.csv("results/tables/mdd_filtered.csv")
+studies <- unique(mdd_filtered$study_id)
+
+# Gather results from association and variation annotation from the GWAS Catalog.
+map_dfr(studies, function(study_id) {
+  
+  variants <- get_variants(study_id = study_id, set_operation = "intersection")
 
-get_study_variants <- function(study_id) {
+  variant_gc_data <- variants@genomic_contexts %>%
+    dplyr::select(variant_id, chromosome_name, chromosome_position)
+
+  variant_var_data <- variants@variants %>%
+    dplyr::select(variant_id, functional_class)
+
+  variant_data <- inner_join(variant_gc_data, variant_var_data, by = c("variant_id"))
   
-  variants <- get_variants(study_id = study_id)
+  associations <- get_associations(study_id = study_id, set_operation = "intersection")
   
-  var_ensg_ids <- variants@ensembl_ids
-  var_variantinfo <- variants@variants %>% 
-    select(variant_id, functional_class)
+  assoc_1 <- associations@risk_alleles %>% 
+    dplyr::select(association_id, variant_id, risk_allele, risk_frequency, genome_wide)
+  assoc_2 <- associations@associations %>% 
+    dplyr::select(association_id, pvalue, pvalue_description, range, beta_number, beta_direction)
+
+  associations_data <- reduce(list(assoc_1, assoc_2), inner_join, by = "association_id")
   
-  var_ensg_ids %>% 
-    left_join(var_variantinfo, by = "variant_id") %>% 
-    mutate(study = study_id)
+  associations_data
+
+  inner_join(associations_data, variant_data, by = "variant_id") %>% 
+    distinct()
   
-}
+}) -> res_gwas
 
-wray2018 <- 'GCST005839'
-howard2018 <- 'GCST005902'
-howard2019 <- 'GCST007342'
-hyde2016 <- 'GCST006041'
+# Filter alleles by their level of significance < 1e-6 
+chrom <- c(1:22, "X", "Y", "MT")
+res_gwas %>% 
+  filter(!is.na(risk_allele), pvalue < 1e-6, chromosome_name %in% chrom) -> risk_alleles
 
-studies <- c(wray2018, howard2018, howard2019, hyde2016)
+# Get ensembl variation information
+ensembl <- useEnsembl("snps", "hsapiens_snp")
 
-gwas_mdd <- lapply(studies, get_study_variants) %>% 
-  bind_rows()
+# Get the correct gene names associated to each variant.
+# This is important because the GWAS Catalog API doesn't provide consistent
+# information about the gene-variant annotation. 
+alleles <- unique(risk_alleles$variant_id)
 
-intersection <- diff_df %>% 
-  inner_join(gwas_mdd, by = c("gene" = "ensembl_id")) %>% 
-  unique()
+dict <- getBM(attributes = c("ensembl_gene_name", "refsnp_id"),
+              filters = "snp_filter",
+              values = alleles,
+              mart = ensembl)
 
-intersection %>% 
-  write_csv("results/tables/gwas_intersection.csv")
+# Join information from Ensembl variation
+risk_alleles <- risk_alleles %>% 
+  left_join(dict, by = c("variant_id" = "refsnp_id"))
+
+# Information about the risk alleles
+n_distinct(risk_alleles$variant_id)
+
+# Gather information of TAGs and genes annotated for risk alleles
+load("results/diff_exp/diff_df.rda")
+intersection <- inner_join(risk_alleles, diff_df, by = c("ensembl_gene_name" = "gene"))
 
+# Save 
 save(intersection, file = "results/diff_exp/gwas_intersections.rda")
+write.csv(intersection, file = "results/tables/gwas_intersection.csv", row.names = F, quote = F)
diff --git a/scripts/network.R b/scripts/network.R
index 7b9d019..b73f350 100644
--- a/scripts/network.R
+++ b/scripts/network.R
@@ -75,13 +75,13 @@ addGraph(rdp, g)
 # Using REDER, we selected the best visualization for our network.
 # Nodes and edges coordinates are saved as nodes2 and edges2 in 'results/networks' directory.
 
-# Plot network layoout ----------------------------------------------------
+# Plot network layout ----------------------------------------------------
 
-# nodes <- read_tsv("results/networks/nodes2")
-# edges <- read_delim("results/networks/edges2", delim = "\t")
+nodes <- read_tsv("results/networks/model_nodes.txt")
+edges <- read_delim("results/networks/model_edges.txt")
 
-nodes <- read_tsv("~/Área de trabalho/redes/v3/nodes4")
-edges <- read_delim("~/Área de trabalho/redes/v3/edges4", delim = "\t")
+# Import nodes coordinates determined by vivagraph
+layout <- read.csv("results/networks/layout.csv")
 
 # Mark nodes as GWAS
 nodes %<>% 
@@ -90,8 +90,8 @@ nodes %<>%
 # Plot
 g <- graph_from_data_frame(edges, nodes, directed = F)
 
-V(g)$x <- nodes$x
-V(g)$y <- nodes$y
+V(g)$x <- layout[,1]
+V(g)$y <- layout[,2]
 V(g)$size <- 1
 V(g)$a <- ifelse(V(g)$alias %in% unique(diff_df$hgnc_symbol[diff_df$type == "DGE"]), 1, 0)
 V(g)$b <- ifelse(V(g)$alias %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTE"]), 1, 0)
@@ -104,7 +104,7 @@ ggraph(g, x = x, y = y) +
     data = as_data_frame(g, "vertices") %>% filter(gwas == "gwas"),
     colour = NA,
     n = 5,
-    pie_scale = 1.3,
+    pie_scale = 0.5,
   show.legend = F) +
   geom_scatterpie(
     cols = c("a", "b", "c"),
@@ -113,18 +113,23 @@ ggraph(g, x = x, y = y) +
     pie_scale = 0.2,
     show.legend = F
   ) +
-  geom_node_text(aes(label = alias), size = 1.1, nudge_x = 10, nudge_y = 10) + 
+  geom_node_text(aes(label = alias), size = 1.1, nudge_x = 2, nudge_y = 4) + 
   #geom_node_label(aes(label = alias)) + 
   scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
   coord_fixed() +
   theme_graph() -> p
 
 # Save 
-svg(filename = "results/plots_paper/rede2.svg", height = 10, width = 10)
+
+if(!dir.exists("results/plots_paper/")) {
+  dir.create("results/plots_paper")
+}
+
+svg(filename = "results/plots_paper/network.svg", height = 10, width = 10)
 print(p)
 dev.off()
 
-# Percentage of total genes in the network: 43,72%%
+# Percentage of total genes in the network: 51,52%%
 n_distinct(nodes$alias) / n_distinct(diff_df$hgnc_symbol)
 
 
diff --git a/scripts/network_layout.R b/scripts/network_layout.R
new file mode 100644
index 0000000..2f60416
--- /dev/null
+++ b/scripts/network_layout.R
@@ -0,0 +1,16 @@
+
+# Create network layout with vivagraph ------------------------------------
+
+library(easylayout)
+
+# Organize main layout
+layout <- easylayout::vivagraph(g)
+
+# Pin unconnected nodes
+layout <- easylayout::vivagraph(g, layout = layout, pin_nodes = TRUE, pinned_cols = 9, pinned_rows = 10)
+
+# Save layout
+colnames(layout) <- c("x", "y")
+
+layout %>%
+  write.csv("results/networks/layout.csv", quote = F, row.names = F)
diff --git a/scripts/organize_dge_dte_after_filtering.R b/scripts/organize_dge_dte_after_filtering.R
index ac22cec..0ba17d8 100644
--- a/scripts/organize_dge_dte_after_filtering.R
+++ b/scripts/organize_dge_dte_after_filtering.R
@@ -16,7 +16,7 @@ imap_dfr(lrt_comp, function(x, y) {
         tibble::rownames_to_column("tx") %>% 
         mutate(tx = gsub("\\.+\\d+", "", tx),
                group = y) %>% 
-        select(tx, logFC, group)
+        dplyr::select(tx, logFC, group)
     return(df)
 }) -> logFC_tx
 
@@ -30,7 +30,7 @@ df_res_padj_tx_out_filtered <- anti_join(df_res_padj_tx, outliers_samples_dte, b
 load("results/diff_exp/edger_gene_rin_ph_diff.rda")
 df_res_padj_gene_out_filtered <- anti_join(df_edger_ph_rin_group_gene, outliers_samples_dge, by = c("gene", "group"))
 
-save(df_res_padj_gene_out_filtered, df_res_padj_tx_out_filtered, file = "df_res_dge_dte.rda")
+save(df_res_padj_gene_out_filtered, df_res_padj_tx_out_filtered, file = "results/diff_exp/df_res_dge_dte.rda")
 
 
 
diff --git a/scripts/outliers_edge_ppcseq_gene.R b/scripts/outliers_edge_ppcseq_gene.R
index 4744c10..3099470 100644
--- a/scripts/outliers_edge_ppcseq_gene.R
+++ b/scripts/outliers_edge_ppcseq_gene.R
@@ -22,6 +22,8 @@ counts <- txi$counts
 
 # Identify outliers genes in each comparison group
 
+ann$run <- rownames(ann)
+
 comp <- paste(rep(unique(ann$region), each = 2), unique(ann$gender), sep = "_")
 
 map(comp, function(c) {
diff --git a/scripts/plots.rmd b/scripts/plots.rmd
index 8741963..f469e59 100644
--- a/scripts/plots.rmd
+++ b/scripts/plots.rmd
@@ -13,6 +13,7 @@ Load required packages:
 ```{r, warning=FALSE, message=FALSE}
 library(tidyverse)
 library(patchwork)
+library(VennDiagram)
 library(UpSetR)
 library(ggnewscale)
 library(pals)
@@ -20,7 +21,7 @@ library(magrittr)
 library(ggh4x)
 library(AnnotationDbi)
 library(org.Hs.eg.db)
-library(xlsx)
+library(openxlsx)
 library(extrafont)
 library(VennDiagram)
 library(ggvenn)
@@ -151,7 +152,7 @@ df_plot %>%
 ggplot(aes(x = as.numeric(x_axis), y = n, fill = type)) +
   geom_bar(stat = "identity", position = "stack") +
   facet_grid(cols = vars(region)) + 
-  scale_y_continuous(name = "Number of transcriptionally altered genes", limits = c(0, 350), breaks = seq(0, 350, 50), minor_breaks = F) +
+  scale_y_continuous(name = "Number of transcriptionally altered genes", limits = c(0, 460), breaks = seq(0, 460, 50), minor_breaks = F) +
   #facet_zoom(x = x_axis %in% c("Female", "Male", "Intersection")) +
   scale_fill_manual(name = "", values = color_scale) +
   scale_x_continuous("",
@@ -263,8 +264,7 @@ df_plot2 <- bind_rows(tmp_1, tmp_2)
 df_plot2 %<>% 
   mutate(exclusive = factor(exclusive, 
                             levels = c("2", "3",
-                                       "4", "5",
-                                       "Exclusive")),
+                                       "4", "Exclusive")),
          sex = factor(sex, 
                       levels = c("female", "male"), labels = c("Female", "Male"))
         ) %>% 
@@ -283,9 +283,12 @@ df_plot2 %>%
   summarise(n_total = sum(n)) -> tmp_6
 
 # df_plot3 holds the number of genes in the intersection of females and males in each region
-df_plot3 <- inner_join(tmp_6, tmp_5, by = "region")
+df_plot3 <- left_join(tmp_6, tmp_5, by = "region")
 df_plot3 %<>% 
-  mutate(p_intersect = n_intersection/n_total)
+  mutate(
+    n_intersection = ifelse(is.na(n_intersection), 0, n_intersection),
+    p_intersect = n_intersection/n_total
+  )
 
 # Join exclusivity information and intersection information
 df_plot2 <- inner_join(df_plot2, df_plot3, by = c("region", "sex"))
@@ -299,10 +302,9 @@ df_plot2 <- inner_join(df_plot2, tmp7, by = "sex")
 
 # Define colors to each intersection
 cols_intersects <- c(
-  "2" = "grey80", 
-  "3" = "grey60", 
-  "4" = "grey40", 
-  "5" = "black",
+  "2" = "grey40", 
+  "3" = "grey80", 
+  "4" = "black",
   "Exclusive" = "#8a0cb1ff"
 )
 
@@ -434,7 +436,7 @@ lapply(c(
 })
 
 # Create dataframe with gwas infos
-df <- data.frame(hgnc_symbol = unique(gwas_intersections$gene_name), gwas = "gwas")
+df <- data.frame(hgnc_symbol = unique(gwas_intersections$hgnc_symbol), gwas = "gwas")
 
 # Join gwas info with intersections info
 tmp <- inner_join(genes_by_sex, diff_df, by = c("hgnc_symbol"))
@@ -484,35 +486,36 @@ ggsave("results/plots_paper/intersect_sex_by_gwas.png", width = 5, height = 4)
 load("results/important_variables/ann.rda")
 
 ann %>% 
+  rownames_to_column("run") %>% 
   dplyr::select(run, phenotype, gender, region) %>% 
   count(phenotype, gender, region, name = "number_of_samples") %>% 
   arrange(gender, region) %>% 
-  write.xlsx(file = "results/tables/number_of_samples.xlsx", row.names = F)
+  openxlsx::write.xlsx(file = "results/tables/number_of_samples.xlsx", rowNames = F)
 ```
 
 ## Supplementary Table 2
 
 ```{r}
 diff_df %>% 
-  write.xlsx(file = "results/tables/TAG.xlsx", row.names = F)
+  openxlsx::write.xlsx(file = "results/tables/TAG.xlsx", row.names = F)
 ```
 
 ## Supplementary Table 3
 
 ```{r}
 genes_by_group_female %>% 
-  write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Female_Intersections")
+  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Female_Intersections")
 
 genes_by_group_male %>% 
-  write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Male_Intersections",
+  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Male_Intersections",
              append = T)
 
 genes_by_sex %>% 
-  write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Sex_Intersections",
+  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Sex_Intersections",
              append = T)
 
 genes_by_regions %>% 
-  write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Regions_Intersections",
+  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Regions_Intersections",
              append = T)
 
 ```
@@ -530,7 +533,7 @@ tmp %>%
   # left_join(gene_name, by = c("genes" = "ENSEMBL")) %>% 
   unique() %>% 
   write_csv("results/tables/intersect_by_type_and_gwas.csv", quote_escape = "none") %>% 
-  write.xlsx(file = "results/tables/intersect_by_type_and_gwas.xlsx", row.names = F, showNA = F)
+  openxlsx::write.xlsx(file = "results/tables/intersect_by_type_and_gwas.xlsx", row.names = F, showNA = F)
 
 overlap_list(l_group_female) %>% 
   tibble::rownames_to_column("gene") %>% 
@@ -539,7 +542,7 @@ overlap_list(l_group_female) %>%
   arrange(desc(exclusive)) %>% 
   unique() %>% 
   write_csv("results/tables/intersect_regions_by_sex_female.csv", quote_escape = "none") %>% 
-  write.xlsx(file = "results/tables/intersect_regions_by_sex_female.xlsx", row.names = F, showNA = F)
+  openxlsx::write.xlsx(file = "results/tables/intersect_regions_by_sex_female.xlsx", row.names = F, showNA = F)
 
 overlap_list(l_group_male) %>% 
   tibble::rownames_to_column("gene") %>% 
@@ -548,7 +551,7 @@ overlap_list(l_group_male) %>%
   arrange(desc(exclusive)) %>% 
   unique() %>% 
   write_csv("results/tables/intersect_regions_by_sex_male.csv", quote_escape = "none") %>% 
-  write.xlsx(file = "results/tables/intersect_regions_by_sex_male.xlsx", row.names = F, showNA = F)
+  openxlsx::write.xlsx(file = "results/tables/intersect_regions_by_sex_male.xlsx", row.names = F, showNA = F)
 
 ```
 

From c71b8e5bb1d7381e47f81f8c388e269ed3d9c0b2 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Wed, 3 May 2023 14:20:19 -0300
Subject: [PATCH 06/24] Biotype analysis redone beacuse of the new set TAGs

---
 scripts/enrichment.R         |  1 +
 scripts/summarise_biotypes.R | 67 +++++++++++++++++++++++-------------
 2 files changed, 45 insertions(+), 23 deletions(-)

diff --git a/scripts/enrichment.R b/scripts/enrichment.R
index 18628b6..4ff7329 100644
--- a/scripts/enrichment.R
+++ b/scripts/enrichment.R
@@ -84,6 +84,7 @@ transform_to_df <- function(enrichment, padj_cutoff = 0.05){
 save_df <- function(enrichment, file){
   enrichment %>%
     bind_rows() %>%
+    mutate(qvalue = scales::scientific(qvalue)) %>% 
     write_csv(file=file)
 }
 
diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index fc025a1..b000aef 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -1,21 +1,23 @@
 library(dplyr)
 library(purrr)
 library(ggplot2)
+library(patchwork)
+library(stringr)
 library(rtracklayer)
 library(GenomicFeatures)
 
-# 1. Carregando GTF ---------------------------------------
-gtf <- "./data/Homo_sapiens.GRCh38.97.chr_patch_hapl_scaff.gtf.gz"
+# 1. Load GTF ---------------------------------------
+gtf <- "./data/genome/Homo_sapiens.GRCh38.97.gtf.gz"
 
 gtf_data <- import(gtf)
 
-# 2. Lendo DGE/DTE e pegando os biotipos ---------------------------------------
+# 2. Import DGE and DTE results and get feature biotypes -------------
 load("./results/diff_exp/diff_df.rda")
 
 dge_genes <- diff_df %>%
   filter(type == "DGE")
 
-# 2.1. Pegando biotipo dos DGE ---------------------------------------
+# 2.1 Get DGE biotypes -----------------------------------------------
 dge_w_biotype <- gtf_data[, c("gene_id", "gene_biotype")] %>%
   as.data.frame() %>%
   filter(gene_id %in% dge_genes$gene) %>%
@@ -26,12 +28,12 @@ dge_w_biotype <- gtf_data[, c("gene_id", "gene_biotype")] %>%
 
 readr::write_csv(dge_w_biotype, "results/diff_exp/dge_w_biotype.csv")
 
-# 2.2. Pegando biotipo dos DTE ---------------------------------------
+# 2.2. Get DTE biotypes ----------------------------------------------
 load("./results/diff_exp/diff_tx_corrected.rda")
 
 dte_genes <- df_res_padj_tx %>%
   dplyr::select(txID, transcript, group) %>%
-  filter(transcript < 0.01)
+  filter(transcript < 0.05)
 
 dte_w_biotype <-
   gtf_data[, c("transcript_id", "transcript_biotype")] %>%
@@ -43,47 +45,66 @@ dte_w_biotype <-
   dplyr::select(transcript_id, transcript_biotype, group)
 
 readr::write_csv(dte_w_biotype, "results/diff_exp/dte_w_biotype.csv")
-
-# 2.3. Pegando biotipo dos DTU ---------------------------------------
+ 
+# 2.3. Get DTU biotypes ---------------------------------------------
 
 dtu_w_biotype <- readr::read_csv("results/ISA/dtu_w_biotype.csv")
 
-# 3. Plotando as porcentagens ---------------------------------------
-plot_biotype_bar <- function(data, id_col, n_col) {
+# Plot  ---------------------------------------
+plot_biotype_bar <- function(data, id_col, n_col, color) {
   
   id_col <- enquo(id_col)
   n_col <- enquo(n_col)
   
   data %>% 
     ggplot(aes(x = reorder(!!id_col, dplyr::desc(!!n_col)), y = !!n_col)) +
-    geom_col() +
-    scale_y_continuous(labels = scales::percent_format(scale = 1)) +
+    geom_col(fill = color) + 
+    scale_y_continuous(labels = scales::percent_format(scale = 1), name = "", limits = c(0, 100)) +
     coord_flip() +
-    labs(
-      y = "Porcentagem de Genes",
-      x = "Biotipo",
-    )
-  
+    theme_bw() +
+    theme(panel.grid.minor = element_blank(),
+          plot.margin = margin(-1, 0, -1, 0))
 }
 
 dge_plot <- dge_w_biotype %>% 
   group_by(gene_biotype) %>% 
   summarise(biotype_n = n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
   ungroup() %>% 
-  plot_biotype_bar(. , id_col = gene_biotype, n_col = biotype_n)
+  mutate(type = "DGE") %>% 
+  dplyr::rename(biotype = gene_biotype)
 
 dte_plot <- dte_w_biotype %>%
   group_by(transcript_biotype) %>%
   summarise(biotype_n = n() / length(unique(dte_w_biotype$transcript_id))* 100) %>%
   ungroup() %>%
-  plot_biotype_bar(., id_col = transcript_biotype, n_col = biotype_n)
+  mutate(type = "DTE") %>% 
+  dplyr::rename(biotype = transcript_biotype)
 
 dtu_plot <- dtu_w_biotype %>%
   group_by(iso_biotype) %>%
   summarise(biotype_n = n() / length(unique(dtu_w_biotype$isoform_id))* 100) %>%
   ungroup() %>%
-  plot_biotype_bar(., id_col = iso_biotype, n_col = biotype_n)
+  mutate(type = "DTU") %>%
+  dplyr::rename(biotype = iso_biotype)
+
+df_plot <- Reduce(bind_rows, list(dge_plot, dte_plot, dtu_plot))
+df_plot$biotype <- gsub("_", " ", df_plot$biotype)
+
+# Plot feature biotypes
+
+color_scale <- c("DGE" = "#0ac80aff", "DTE" = "#4f4affff", "DTU" = "#ff822fff")
+
+ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(biotype_n)), y = biotype_n, fill = type)) +
+  geom_col(show.legend = F) + 
+  scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
+  facet_wrap(nrow = 3, ncol = 1, facets = vars(type), scales = "free_y", strip.position = "right") +
+  scale_fill_manual(values = color_scale) + 
+  labs(x = "Feature biotypes", y = "% of feature biotype by the total features") +
+  coord_flip() +
+  theme_bw() +
+  theme(panel.grid.minor = element_blank()) -> biotype_plot
+
+
+# Save
+ggsave(biotype_plot, file = "results/plots_paper/biotype_plot.pdf", width = 7, height = 4)
 
-ggsave(dge_plot, filename = "results/diff_exp/dge_biotypes.pdf")
-ggsave(dte_plot, filename = "results/diff_exp/dte_biotypes.pdf")
-ggsave(dtu_plot, filename = "results/diff_exp/dtu_biotypes.pdf")

From 6c7b085742dbc3a702a1ffa588ca006f4544812f Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Fri, 5 May 2023 10:20:54 -0300
Subject: [PATCH 07/24] Added relationship of samples to each patient

---
 results/tables/patients_metadata.csv     | 266 +++++++++++++++++++++++
 scripts/create_metadata_patients_table.R |  44 ++++
 2 files changed, 310 insertions(+)
 create mode 100644 results/tables/patients_metadata.csv
 create mode 100644 scripts/create_metadata_patients_table.R

diff --git a/results/tables/patients_metadata.csv b/results/tables/patients_metadata.csv
new file mode 100644
index 0000000..6362dd8
--- /dev/null
+++ b/results/tables/patients_metadata.csv
@@ -0,0 +1,266 @@
+sample_id,ph,rin,pmi,age,group,gender,region,patients
+SRR6443679,6.57,7.2,32,49,MDD,male,nac,40
+SRR6443680,6.91,7.7,33.5,53,MDD,male,nac,51
+SRR5961796,6.49,7.9,12,47,CTRL,male,ofc,14
+SRR5961797,6,6.8,24,41,CTRL,male,ofc,17
+SRR5961798,6.67,7.1,29.5,31,CTRL,male,ofc,20
+SRR5961799,6.74,6.7,27.75,19,CTRL,male,ofc,23
+SRR5961800,6.42,7.7,19.5,46,CTRL,male,ofc,28
+SRR5961801,6.26,5.8,29.75,40,CTRL,male,ofc,32
+SRR5961802,6.57,7,32,49,MDD,male,ofc,40
+SRR5961803,6.68,7.8,18,33,CTRL,male,ofc,43
+SRR5961804,6.84,6.8,44.5,38,CTRL,male,ofc,45
+SRR5961805,6.91,8,33.5,53,MDD,male,ofc,51
+SRR5961806,6,4.8,19,39,MDD,male,ofc,56
+SRR5961807,6.75,7.5,24,55,CTRL,male,ofc,57
+SRR5961808,6.86,7.5,30,38,MDD,male,ofc,61
+SRR5961809,6.73,7.4,20,25,MDD,female,ofc,63
+SRR5961810,6.68,7.4,24,22,MDD,male,ofc,67
+SRR5961811,6.93,6.1,36,28,MDD,male,ofc,68
+SRR5961812,6.53,6.9,15,46,MDD,female,ofc,69
+SRR5961813,6.79,6.9,36,55,MDD,female,ofc,72
+SRR5961814,6.73,7.3,29.5,44,CTRL,female,ofc,74
+SRR5961815,6.96,5.7,27,29,MDD,male,ofc,84
+SRR5961816,6.93,8.8,32,68,MDD,male,ofc,93
+SRR5961817,6.37,6.8,18.5,39,MDD,male,ofc,105
+SRR5961818,6.81,7.8,49.5,40,MDD,female,ofc,111
+SRR5961819,6.95,6.5,50,63,MDD,male,ofc,113
+SRR5961820,6.55,6.2,56,25,MDD,female,ofc,114
+SRR5961821,6.77,8.3,28.5,54,MDD,female,ofc,117
+SRR5961822,6.56,7.9,49,48,MDD,male,ofc,120
+SRR5961823,6.85,6.8,56,67,MDD,male,ofc,124
+SRR5961824,6.83,6.1,59,46,CTRL,male,ofc,128
+SRR5961825,6.89,8.2,41,32,MDD,female,ofc,129
+SRR5961826,6.11,5.7,10,52,CTRL,male,ofc,150
+SRR5961827,6.5,8.5,2.5,55,MDD,female,ofc,153
+SRR5961828,6.4,6.8,7.5,79,CTRL,female,ofc,162
+SRR5961829,6.25,9.1,6.5,64,MDD,male,ofc,183
+SRR5961830,6.1,5.7,17,72,CTRL,female,ofc,189
+SRR5961831,6.7,6.7,12,41,MDD,female,ofc,198
+SRR5961832,6.4,8,4,29,CTRL,male,ofc,199
+SRR5961833,6.5,7.4,44,45,CTRL,female,ofc,201
+SRR5961834,6.5,8,17.5,48,MDD,female,ofc,205
+SRR5961835,7,8,106,82,CTRL,female,ofc,212
+SRR5961836,6.9,7.6,7.5,36,MDD,female,ofc,222
+SRR5961837,6.5,8.3,4.5,52,MDD,female,ofc,235
+SRR5961838,6.7,7.9,38,60,CTRL,female,ofc,236
+SRR5961839,7,6.1,2,22,CTRL,female,ofc,238
+SRR5961840,6.21,8.3,8.5,68,CTRL,female,ofc,242
+SRR5961841,6.27,7.3,3,59,MDD,female,ofc,246
+SRR5961842,6.76,7.4,23.5,59,CTRL,male,ofc,247
+SRR5961843,6.71,8.3,16,51,CTRL,female,ofc,249
+SRR5961844,6.49,7.8,12,47,CTRL,male,dlpfc,14
+SRR5961845,6,7.6,24,41,CTRL,male,dlpfc,17
+SRR5961846,6.67,6.9,29.5,31,CTRL,male,dlpfc,20
+SRR5961847,6.74,7.7,27.75,19,CTRL,male,dlpfc,23
+SRR5961848,6.42,7.7,19.5,46,CTRL,male,dlpfc,28
+SRR5961849,6.26,6.5,29.75,40,CTRL,male,dlpfc,32
+SRR5961850,6.57,7.8,32,49,MDD,male,dlpfc,40
+SRR5961851,6.68,7.2,18,33,CTRL,male,dlpfc,43
+SRR5961852,6.84,7.2,44.5,38,CTRL,male,dlpfc,45
+SRR5961853,6.91,7.7,33.5,53,MDD,male,dlpfc,51
+SRR5961854,6,6.6,19,39,MDD,male,dlpfc,56
+SRR5961855,6.75,7.2,24,55,CTRL,male,dlpfc,57
+SRR5961856,6.86,6.9,30,38,MDD,male,dlpfc,61
+SRR5961857,6.73,7.2,20,25,MDD,female,dlpfc,63
+SRR5961858,6.68,6.8,24,22,MDD,male,dlpfc,67
+SRR5961859,6.93,5.6,36,28,MDD,male,dlpfc,68
+SRR5961860,6.53,7.5,15,46,MDD,female,dlpfc,69
+SRR5961861,6.79,7.5,36,55,MDD,female,dlpfc,72
+SRR5961862,6.73,6.9,29.5,44,CTRL,female,dlpfc,74
+SRR5961863,6.96,7.6,27,29,MDD,male,dlpfc,84
+SRR5961864,6.93,8.8,32,68,MDD,male,dlpfc,93
+SRR5961865,6.37,7.6,18.5,39,MDD,male,dlpfc,105
+SRR5961866,6.81,6.7,49.5,40,MDD,female,dlpfc,111
+SRR5961867,6.95,7.4,50,63,MDD,male,dlpfc,113
+SRR5961868,6.55,7.1,56,25,MDD,female,dlpfc,114
+SRR5961869,6.77,7.7,28.5,54,MDD,female,dlpfc,117
+SRR5961870,6.56,7.7,49,48,MDD,male,dlpfc,120
+SRR5961871,6.85,7.2,56,67,MDD,male,dlpfc,124
+SRR5961872,6.83,8.2,59,46,CTRL,male,dlpfc,128
+SRR5961873,6.89,6.9,41,32,MDD,female,dlpfc,129
+SRR5961874,6.11,6.5,10,52,CTRL,male,dlpfc,150
+SRR5961875,6.5,7.5,2.5,55,MDD,female,dlpfc,153
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+SRR5961965,6.85,5.8,56,67,MDD,male,ains,124
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+SRR5961967,6.89,5.8,41,32,MDD,female,ains,129
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+SRR5961969,6.5,7.2,2.5,55,MDD,female,ains,153
+SRR5961970,6.4,5.2,7.5,79,CTRL,female,ains,162
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+SRR5961978,6.9,8,7.5,36,MDD,female,ains,222
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+SRR5961980,6.7,8.6,38,60,CTRL,female,ains,236
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+SRR5961982,6.21,8.4,8.5,68,CTRL,female,ains,242
+SRR5961983,6.27,8.3,3,59,MDD,female,ains,246
+SRR5961984,6.76,8.1,23.5,59,CTRL,male,ains,247
+SRR5961985,6.71,8.2,16,51,CTRL,female,ains,249
+SRR5961986,6.49,7.6,12,47,CTRL,male,nac,14
+SRR5961987,6,8,24,41,CTRL,male,nac,17
+SRR5961988,6.67,7.1,29.5,31,CTRL,male,nac,20
+SRR5961989,6.74,6.5,27.75,19,CTRL,male,nac,23
+SRR5961990,6.42,7.5,19.5,46,CTRL,male,nac,28
+SRR5961991,6.26,5.6,29.75,40,CTRL,male,nac,32
+SRR5961992,6.57,7.2,32,49,MDD,male,nac,40
+SRR5961993,6.68,7.8,18,33,CTRL,male,nac,43
+SRR5961994,6.84,5.9,44.5,38,CTRL,male,nac,45
+SRR5961995,6.91,7.7,33.5,53,MDD,male,nac,51
+SRR5961996,6,4.9,19,39,MDD,male,nac,56
+SRR5961997,6.75,4.4,24,55,CTRL,male,nac,57
+SRR5961998,6.86,7.7,30,38,MDD,male,nac,61
+SRR5961999,6.73,8.1,20,25,MDD,female,nac,63
+SRR5962000,6.68,8.4,24,22,MDD,male,nac,67
+SRR5962001,6.93,7.5,36,28,MDD,male,nac,68
+SRR5962002,6.53,8.4,15,46,MDD,female,nac,69
+SRR5962003,6.79,8,36,55,MDD,female,nac,72
+SRR5962004,6.73,7.2,29.5,44,CTRL,female,nac,74
+SRR5962005,6.96,7.7,27,29,MDD,male,nac,84
+SRR5962006,6.93,8.2,32,68,MDD,male,nac,93
+SRR5962007,6.37,7.5,18.5,39,MDD,male,nac,105
+SRR5962008,6.81,7.7,49.5,40,MDD,female,nac,111
+SRR5962009,6.95,7.8,50,63,MDD,male,nac,113
+SRR5962010,6.55,7.6,56,25,MDD,female,nac,114
+SRR5962011,6.77,8.7,28.5,54,MDD,female,nac,117
+SRR5962012,6.56,8.5,49,48,MDD,male,nac,120
+SRR5962013,6.85,8.3,56,67,MDD,male,nac,124
+SRR5962014,6.83,8.8,59,46,CTRL,male,nac,128
+SRR5962015,6.89,8.3,41,32,MDD,female,nac,129
+SRR5962016,6.11,6.8,10,52,CTRL,male,nac,150
+SRR5962017,6.5,7.7,2.5,55,MDD,female,nac,153
+SRR5962018,6.4,7.2,7.5,79,CTRL,female,nac,162
+SRR5962019,6.25,8.1,6.5,64,MDD,male,nac,183
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+SRR5962035,6,6.5,24,41,CTRL,male,sub,17
+SRR5962036,6.67,7.3,29.5,31,CTRL,male,sub,20
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+SRR5962047,6.53,7.7,15,46,MDD,female,sub,69
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+SRR5962060,6.89,7.7,41,32,MDD,female,sub,129
+SRR5962061,6.11,6.3,10,52,CTRL,male,sub,150
+SRR5962062,6.5,6.7,2.5,55,MDD,female,sub,153
+SRR5962063,6.25,7,6.5,64,MDD,male,sub,183
+SRR5962064,6.1,5.1,17,72,CTRL,female,sub,189
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+SRR5962066,6.4,6.4,4,29,CTRL,male,sub,199
+SRR5962067,6.5,6.4,44,45,CTRL,female,sub,201
+SRR5962068,6.5,7.7,17.5,48,MDD,female,sub,205
+SRR5962069,6.9,6.6,7.5,36,MDD,female,sub,222
+SRR5962070,6.5,7.7,4.5,52,MDD,female,sub,235
+SRR5962071,6.7,7.3,38,60,CTRL,female,sub,236
+SRR5962072,7,7.3,2,22,CTRL,female,sub,238
+SRR5962073,6.21,7.6,8.5,68,CTRL,female,sub,242
+SRR5962074,6.27,7.6,3,59,MDD,female,sub,246
+SRR5962075,6.76,7.2,23.5,59,CTRL,male,sub,247
+SRR5962076,6.71,8,16,51,CTRL,female,sub,249
diff --git a/scripts/create_metadata_patients_table.R b/scripts/create_metadata_patients_table.R
new file mode 100644
index 0000000..2f255be
--- /dev/null
+++ b/scripts/create_metadata_patients_table.R
@@ -0,0 +1,44 @@
+
+# Relate patients to their respective samples -----------------------------
+
+library(dplyr)
+library(tidyr)
+library(janitor)
+
+# Get organized metadata about each patient -------------------------------
+# This metadata comes from the supplementary material that can be found here:
+# http://neuroscience.mssm.edu/nestler/contecenter/Cohort%201%20Metadata.pdf
+patients <- read.csv("~/Downloads/Metadata.csv")
+
+# Organize data for further merge
+colnames(patients) <- make_clean_names(colnames(patients))
+patients <- patients %>% 
+  pivot_longer(cg25:sub, names_to = "region", values_to = "rin") %>% 
+  select(patients = samples, gender, region, group, age, pmi, ph, rin) %>% 
+  mutate(across(where(is.numeric), ~ as.character(.)),
+         gender = tolower(gender))
+
+# Get samples metadata ----------------------------------------------------
+
+ann <- read.csv("data/meta/SraRunTable.txt", stringsAsFactors = F, header = T)
+colnames(ann) <- tolower(colnames(ann))
+ann <- ann %>% 
+  dplyr::select(run, ph, rin, pmi, age, phenotype, gender, tissue, organism) %>% 
+  filter(organism == "Homo sapiens") %>% 
+  mutate(region = case_when(
+    tissue == "Orbitofrontal (OFC; BA11)" ~ "OFC",
+    tissue == "Dorsolateral prefrontal cortex (dlPFC; BA8/9)" ~ "dlPFC",
+    tissue == "Cingulate gyrus 25 (Cg25)" ~ "Cg25",
+    tissue == "Anterior Insula (aINS)" ~ "aINS",
+    tissue == "Nucleus Accumbens (Nac)" ~ "Nac",
+    tissue == "Subiculum (Sub)" ~ "Sub"
+  ),
+  region = tolower(region)) %>% 
+  dplyr::rename(sample_id = run) %>% 
+  dplyr::select(sample_id, ph, rin, pmi, age, group = phenotype, gender, region) %>% 
+  mutate(across(where(is.numeric), ~ as.character(.)))
+
+
+patients_metadata_table <- inner_join(ann, patients, by = c("gender", "group", "region", "ph", "rin", "pmi", "age"))
+
+write.csv(patients_metadata_table, file = "results/tables/patients_metadata.csv", quote = F, row.names = F)

From f95495f416c85fba7c0114d26943b5c7f3437260 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Mon, 8 May 2023 16:40:15 -0300
Subject: [PATCH 08/24] fix: added two genes df

---
 scripts/build_symreg_df.R | 51 +++++++++++++++++++++++++++++++++++++++
 1 file changed, 51 insertions(+)
 create mode 100644 scripts/build_symreg_df.R

diff --git a/scripts/build_symreg_df.R b/scripts/build_symreg_df.R
new file mode 100644
index 0000000..901aa2e
--- /dev/null
+++ b/scripts/build_symreg_df.R
@@ -0,0 +1,51 @@
+library(dplyr)
+
+load("results/diff_exp/diff_df.rda")
+
+load("results/txi/txi_gene.rda")
+
+load("results/important_variables/ann.rda")
+
+get_expr_from_gene_list <- function(genelist, symbol_list) {
+  txi$abundance[rownames(txi$abundance) %in% genelist,] %>%
+    t() %>%
+    as.data.frame() %>%
+    tibble::rownames_to_column() %>%
+    setNames(., c("run", symbol_list))
+}
+
+metadata <- ann %>%
+  mutate(phenotype_reg = ifelse(phenotype == "MDD", 1, 0),
+         run = rownames(.)) %>%
+  dplyr::select(-c(group))
+
+genes_interest <- diff_df %>%
+  filter(type == "DGE") %>%
+  dplyr::select(gene, hgnc_symbol) %>%
+  distinct()
+
+dge_tpms <-
+  get_expr_from_gene_list(genes_interest$gene, genes_interest$hgnc_symbol)
+
+full_data <- dge_tpms %>%
+  left_join(metadata, by = "run")
+
+selected_genes <- c("ATAT1", "DDX39B")
+
+two_genes_df <- diff_df %>%
+  filter(hgnc_symbol == selected_genes) %>%
+  dplyr::select(gene, hgnc_symbol) %>%
+  distinct()
+
+selected_tpms <-
+  get_expr_from_gene_list(two_genes_df$gene, selected_genes)
+
+two_gene_data <- selected_tpms %>%
+  left_join(metadata, by = "run")
+
+if(!dir.exists("results/sym_reg/")) {
+  dir.create("results/sym_reg/")
+}
+
+readr::write_tsv(two_gene_data, "results/sym_reg/selected_genes_for_reg.tsv")
+readr::write_tsv(full_data, "results/sym_reg/genes_for_reg.tsv")

From 53f5c14a9b82028adbeb20c5d873f85874d3572d Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 9 May 2023 11:20:48 -0300
Subject: [PATCH 09/24] chore: added new intersection tables, removed files
 saved in wrong places

---
 gwas_intersection.csv                         |  14 --
 remaining_samples.sh                          |  39 ------
 results/tables/TAG.xlsx                       | Bin 46822 -> 46822 bytes
 .../tables/intersect_by_type_and_gwas.xlsx    | Bin 61458 -> 61459 bytes
 .../intersect_regions_by_sex_female.xlsx      | Bin 46004 -> 46004 bytes
 .../tables/intersect_regions_by_sex_male.xlsx | Bin 33415 -> 33415 bytes
 results/tables/intersection_tables.xlsx       | Bin 32241 -> 32242 bytes
 results/tables/number_of_samples.xlsx         | Bin 6872 -> 6872 bytes
 scripts/teste                                 | 125 ++++++++++++++++++
 9 files changed, 125 insertions(+), 53 deletions(-)
 delete mode 100644 gwas_intersection.csv
 delete mode 100644 remaining_samples.sh
 create mode 100644 scripts/teste

diff --git a/gwas_intersection.csv b/gwas_intersection.csv
deleted file mode 100644
index 8359231..0000000
--- a/gwas_intersection.csv
+++ /dev/null
@@ -1,14 +0,0 @@
-association_id,variant_id,risk_allele,risk_frequency,genome_wide,pvalue,pvalue_description,range,beta_number,beta_direction,chromosome_name,chromosome_position,functional_class,ensembl_gene_name,hgnc_symbol,group,type
-41136253,rs58621819,T,0.2097,FALSE,2e-10,NA,[1.01-1.02],NA,NA,11,65547359,intron_variant,ENSG00000168056,LTBP3,OFC_female,DGE
-41136409,rs12923444,C,0.4375,FALSE,2e-24,NA,[1.02-1.03],NA,NA,16,21628389,intron_variant,ENSG00000197006,METTL9,OFC_female,DGE
-41135995,rs10789214,T,0.5661,FALSE,4e-10,NA,[1.009-1.018],NA,NA,1,66681134,intron_variant,ENSG00000118473,SGIP1,OFC_female,DTE
-41136026,rs17641524,C,0.7909,FALSE,8e-20,NA,[1.02-1.03],NA,NA,1,197735587,splice_region_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
-41136085,rs45510091,A,0.9472,FALSE,8e-21,NA,[1.037-1.057],NA,NA,4,122265238,intron_variant,ENSG00000138688,BLTP1,Cg25_male,DGE
-30547745,rs10127497,T,0.1382,FALSE,1e-08,NA,[0.0064-0.013],0.0097,increase,1,66584461,intron_variant,ENSG00000118473,SGIP1,OFC_female,DTE
-30547749,rs6679379,T,0.2875,FALSE,3e-08,NA,[0.0047-0.0097],0.0072,increase,1,66733473,non_coding_transcript_exon_variant,ENSG00000118473,SGIP1,OFC_female,DTE
-30547797,rs12118513,A,0.2148,FALSE,1e-07,NA,[0.0049-0.0103],0.0076,decrease,1,197547956,intron_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
-30547801,rs17641524,T,0.2086,FALSE,2e-07,NA,[0.0048-0.0102],0.0075,decrease,1,197735587,splice_region_variant,ENSG00000213047,DENND1B,Cg25_male,DTE
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-64732910,rs2894699,T,0.4305,FALSE,4e-09,NA,[0.017-0.033],0.024859993,decrease,7,114419101,intron_variant,ENSG00000128573,FOXP2,Sub_male,DGE
-64733014,rs7146581,T,0.2246,FALSE,2e-08,NA,[0.018-0.037],0.027423386,increase,14,102834735,intron_variant,ENSG00000131323,TRAF3,Nac_female,DTE
-64733043,rs2369818,T,0.4386,FALSE,3e-08,NA,[0.015-0.031],0.023054866,increase,16,21602688,intron_variant,ENSG00000197006,METTL9,OFC_female,DGE
diff --git a/remaining_samples.sh b/remaining_samples.sh
deleted file mode 100644
index a65496c..0000000
--- a/remaining_samples.sh
+++ /dev/null
@@ -1,39 +0,0 @@
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961862/SRR5961862_2.fastq.gz -o SRR5961862_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961863/SRR5961863_2.fastq.gz -o SRR5961863_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961864/SRR5961864_1.fastq.gz -o SRR5961864_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961864/SRR5961864_2.fastq.gz -o SRR5961864_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/008/SRR5961938/SRR5961938_2.fastq.gz -o SRR5961938_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961937/SRR5961937_1.fastq.gz -o SRR5961937_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961937/SRR5961937_2.fastq.gz -o SRR5961937_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961942/SRR5961942_1.fastq.gz -o SRR5961942_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961942/SRR5961942_2.fastq.gz -o SRR5961942_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961940/SRR5961940_1.fastq.gz -o SRR5961940_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961940/SRR5961940_2.fastq.gz -o SRR5961940_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961943/SRR5961943_1.fastq.gz -o SRR5961943_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961943/SRR5961943_2.fastq.gz -o SRR5961943_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961944/SRR5961944_1.fastq.gz -o SRR5961944_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961944/SRR5961944_2.fastq.gz -o SRR5961944_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961946/SRR5961946_1.fastq.gz -o SRR5961946_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961946/SRR5961946_2.fastq.gz -o SRR5961946_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961945/SRR5961945_1.fastq.gz -o SRR5961945_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961945/SRR5961945_2.fastq.gz -o SRR5961945_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961947/SRR5961947_1.fastq.gz -o SRR5961947_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961947/SRR5961947_2.fastq.gz -o SRR5961947_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/008/SRR5961948/SRR5961948_1.fastq.gz -o SRR5961948_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/008/SRR5961948/SRR5961948_2.fastq.gz -o SRR5961948_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/009/SRR5961949/SRR5961949_1.fastq.gz -o SRR5961949_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/009/SRR5961949/SRR5961949_2.fastq.gz -o SRR5961949_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961950/SRR5961950_1.fastq.gz -o SRR5961950_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/000/SRR5961950/SRR5961950_2.fastq.gz -o SRR5961950_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/001/SRR5961951/SRR5961951_1.fastq.gz -o SRR5961951_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/001/SRR5961951/SRR5961951_2.fastq.gz -o SRR5961951_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961952/SRR5961952_1.fastq.gz -o SRR5961952_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/002/SRR5961952/SRR5961952_2.fastq.gz -o SRR5961952_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/003/SRR5961953/SRR5961953_2.fastq.gz -o SRR5961953_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961954/SRR5961954_1.fastq.gz -o SRR5961954_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/004/SRR5961954/SRR5961954_2.fastq.gz -o SRR5961954_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961955/SRR5961955_1.fastq.gz -o SRR5961955_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/005/SRR5961955/SRR5961955_2.fastq.gz -o SRR5961955_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961956/SRR5961956_1.fastq.gz -o SRR5961956_1.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/006/SRR5961956/SRR5961956_2.fastq.gz -o SRR5961956_2.fastq.gz
-curl -L ftp://ftp.sra.ebi.ac.uk/vol1/fastq/SRR596/007/SRR5961957/SRR5961957_1.fastq.gz -o SRR5961957_1.fastq.gz
diff --git a/results/tables/TAG.xlsx b/results/tables/TAG.xlsx
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diff --git a/results/tables/intersect_by_type_and_gwas.xlsx b/results/tables/intersect_by_type_and_gwas.xlsx
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diff --git a/results/tables/intersect_regions_by_sex_female.xlsx b/results/tables/intersect_regions_by_sex_female.xlsx
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diff --git a/results/tables/intersect_regions_by_sex_male.xlsx b/results/tables/intersect_regions_by_sex_male.xlsx
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diff --git a/results/tables/intersection_tables.xlsx b/results/tables/intersection_tables.xlsx
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diff --git a/results/tables/number_of_samples.xlsx b/results/tables/number_of_samples.xlsx
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diff --git a/scripts/teste b/scripts/teste
new file mode 100644
index 0000000..9bd7ec1
--- /dev/null
+++ b/scripts/teste
@@ -0,0 +1,125 @@
+import feyn
+import pandas as pd
+from sklearn.model_selection import train_test_split
+
+
+def get_train_test_types(dataset, random_seed=1024, target="phenotype_reg"):
+    UNWANTED_COLUMNS_FOR_TRAINING = ["run", "phenotype"]
+    data = dataset[dataset.columns.difference(UNWANTED_COLUMNS_FOR_TRAINING)].dropna()
+
+    # Let's record the categorical data types in our dataset (note features will be treated as numerical by default).
+    stypes = {}
+    for f in data.columns:
+        if data[f].dtype == "object":
+            stypes[f] = "c"
+
+    # Split
+    train, test = train_test_split(
+        data, test_size=0.33, stratify=data[target], random_state=random_seed
+    )
+
+    return train, test, stypes
+
+
+def get_models(
+    training_data, stypes, priors, target="phenotype_reg", epochs=20, random_seed=1024
+):
+
+    ql = feyn.QLattice(random_seed=random_seed)
+    ql.update_priors(priors)
+
+    models = ql.auto_run(
+        data=training_data,
+        output_name=target,
+        kind="classification",
+        stypes=stypes,
+        n_epochs=epochs,
+    )
+
+    return models
+
+
+def save_model(model, train, test, filename):
+    model.plot(train, test, filename=f"results/sym_reg/{filename}_summary.html")
+    model.plot_signal(train, filename=f"results/sym_reg/{filename}_signal.svg")
+    model.save(f"results/sym_reg/{filename}_model.json")
+
+
+# From https://github.com/abzu-ai/QLattice-clinical-omics/blob/main/notebooks/functions.py
+def get_models_table(models, train, test, model_name):
+    model_list = []
+    auc_list_train = []
+    auc_list_test = []
+    bic_list = []
+    accuracy_train = []
+    accuracy_test = []
+    feat_list = []
+    function_list = []
+    loss_list = []
+    i = 0
+    for x in models:
+        model_list.append(str(i))
+        auc_list_train.append(str(x.roc_auc_score(train).round(2)))
+        auc_list_test.append(str(x.roc_auc_score(test).round(2)))
+        accuracy_train.append(str(x.accuracy_score(train).round(2)))
+        accuracy_test.append(str(x.accuracy_score(test).round(2)))
+        bic_list.append(str(x.bic.round(2)))
+        feat_list.append(len(x.features))
+        function_list.append(
+            x.sympify(symbolic_lr=False, symbolic_cat=True, include_weights=False)
+        )
+        loss_list.append(x.loss_value)
+        i += 1
+    df = pd.DataFrame(
+        list(
+            zip(
+                model_list,
+                auc_list_train,
+                auc_list_test,
+                accuracy_train,
+                accuracy_test,
+                bic_list,
+                feat_list,
+                function_list,
+                loss_list,
+            )
+        ),
+        columns=[
+            "Model",
+            "AUC Train",
+            "AUC Test",
+            "Accuracy Train",
+            "Accuracy Test",
+            "BIC",
+            "N. Features",
+            "Functional form",
+            "Loss",
+        ],
+    )
+
+    df.to_csv(f"results/sym_reg/{model_name}_table.csv", index=False)
+
+
+def run_models():
+
+    three_gene_data = pd.read_table("results/sym_reg/selected_genes_for_reg.tsv")
+    full_data = pd.read_table("results/sym_reg/genes_for_reg.tsv")
+
+    threeg_train, threeg_test, threeg_types = get_train_test_types(three_gene_data)
+    full_train, full_test, full_types = get_train_test_types(full_data)
+
+    threeg_priors = feyn.tools.estimate_priors(threeg_train, "phenotype_reg", floor=0.1)
+    full_priors = feyn.tools.estimate_priors(full_train, "phenotype_reg", floor=0.1)
+
+    threeg_models = get_models(threeg_train, threeg_types, threeg_priors)
+    full_models = get_models(full_train, full_types, full_priors)
+
+    get_models_table(threeg_models, threeg_train, threeg_test, "three_gene")
+    get_models_table(full_models, full_train, full_test, "all_genes")
+
+    save_model(threeg_models[0], threeg_train, threeg_test, "three_gene")
+    save_model(full_models[0], full_train, full_test, "all_genes")
+
+
+if __name__ == "__main__":
+    run_models()

From cb0336b503c47cd77ef87e82a7c70e8b557f6d54 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 9 May 2023 16:29:59 -0300
Subject: [PATCH 10/24] fix: replaced "gender" by sex on cumulative variance
 plot

---
 scripts/rank_variables.R | 44 +++++++++++++++++++++++++++++-----------
 1 file changed, 32 insertions(+), 12 deletions(-)

diff --git a/scripts/rank_variables.R b/scripts/rank_variables.R
index bdea6cc..199701a 100644
--- a/scripts/rank_variables.R
+++ b/scripts/rank_variables.R
@@ -13,6 +13,9 @@ library(RColorBrewer)
 # Load predicted metadata
 load("results/important_variables/ann_complete.rda")
 
+ann_complete <- ann_complete %>% 
+  dplyr::rename(sex = gender)
+
 # Organize predicted metadata
 ann_regression <- ann_complete
 ann_pca <- ann_complete
@@ -23,7 +26,8 @@ lapply(seq_along(ann_pca), function(i) {
 })
 ann_pca$phenotype <- factor(ann_pca$phenotype, levels = c("1", "2"), labels = c("CTRL", "MDD"))
 ann_pca$region <- sapply(strsplit(ann_pca$group, split = "_"), "[[", 1)
-ann_pca$gender <- factor(ann_pca$gender, levels = c("1", "2"), labels = c("female", "male"))
+ann_pca$sex <- factor(ann_pca$sex, levels = c("1", "2"), labels = c("female", "male"))
+
 
 rm("ann_complete")
 
@@ -77,16 +81,16 @@ p_kallisto <- pca(assay(vds), metadata = ann_regression)
 
 df <- data.frame(PC1 = p_kallisto$rotated[,1],
                  PC2 = p_kallisto$rotated[,2],
-                 gender = ann_pca$gender,
+                 sex = ann_pca$sex,
                  group = paste(ann_pca$region, ann_pca$phenotype, sep = "_"),
                  stringsAsFactors = F)
 cols <- brewer.paired(12)
 cols[11] <- "#e0e05cf8"
 names(cols) <- unique(df$group)[order(sapply(strsplit(unique(df$group), split = "_"), "[[", 1))]
-ggplot(df, aes(x = PC1, y = PC2, col = group, shape = gender)) +
+ggplot(df, aes(x = PC1, y = PC2, col = group, shape = sex)) +
   geom_point(size = 2.5) + 
   scale_color_manual(values = cols, name = "Group") +
-  scale_shape_manual(name = "Gender", values = c(15, 17), labels = c("female" = "Female", "male" = "Male")) +
+  scale_shape_manual(name = "Sex", values = c(15, 17), labels = c("female" = "Female", "male" = "Male")) +
   labs(x = paste0("PC1", " (", round(p_kallisto$variance[1], 2), "%)"),
        y = paste0("PC2", " (", round(p_kallisto$variance[2], 2), "%)")) +
   guides(colour = guide_legend(override.aes = list(size = 3)),
@@ -95,19 +99,34 @@ ggplot(df, aes(x = PC1, y = PC2, col = group, shape = gender)) +
   theme(legend.key.size = unit(10, units = "mm"),
         legend.text = element_text(size = 12),
         legend.title = element_text(size = 12))
-ggsave("results/rank_plots/pca_vst.pdf", width = 10, height = 7)
+
+if(!dir.exists("results/rank_plots/")) {
+  dir.create("results/rank_plots/")
+}
+
+ggsave(plot = last_plot(), "results/rank_plots/pca_vst.pdf", width = 10, height = 7)
+ggsave(plot = last_plot(), "results/rank_plots/pca_vst.png", width = 10, height = 7)
 
 # Screeplot
-pdf("results/rank_plots/screeplot_pca.pdf", width = 10, height = 7)
-screeplot(p_kallisto, vline = findElbowPoint(p_kallisto$variance), components = 1:20)
-dev.off()
+sc_plot <- screeplot(p_kallisto, vline = findElbowPoint(p_kallisto$variance), components = 1:20)
+ggsave(plot = sc_plot, file = "results/rank_plots/screeplot.pdf", width = 10, height = 7)
+ggsave(plot = sc_plot, file = "results/rank_plots/screeplot.png", width = 10, height = 7)
 
 # Eigenplot - spearman correlation between variables and principal components
-pdf("results/rank_plots/eigercorplot_kallisto.pdf", width = 10, height = 7)
+pdf(file = "results/rank_plots/eigencorplot.pdf", width = 10, height = 7)
+eigencorplot(p_kallisto, corFUN = "spearman",
+                         corUSE = 'pairwise.complete.obs',
+                         metavars = c("age", "alcool", "drugs",
+                                      "ph", "medication", "sex", 
+                                      "region", "pmi", "rin", "phenotype"))
+dev.off()
+
+png(file = "results/rank_plots/eigencorplot.png", width = 20, height = 14, units = "cm", res = 300)
 eigencorplot(p_kallisto, corFUN = "spearman",
              corUSE = 'pairwise.complete.obs',
-             metavars = c("age", "alcool", "drugs", "ph", "medication", 
-                          "gender", "region", "pmi", "rin", "phenotype"))
+             metavars = c("age", "alcool", "drugs",
+                          "ph", "medication", "sex", 
+                          "region", "pmi", "rin", "phenotype"))
 dev.off()
 
 # # Poisson distance - See similarities between regions
@@ -139,7 +158,7 @@ dev.off()
 
 # Rank variables by their correlation to each components ------------------
 vars <- c("age", "alcool", "drugs", "ph", "medication", "smoking",
-          "gender", "region", "pmi", "rin", "phenotype")
+          "sex", "region", "pmi", "rin", "phenotype")
 m_cor <- matrix(0, nrow = length(vars), ncol = length(p_kallisto$rotated))
 
 # Create correlation matrix
@@ -190,4 +209,5 @@ ggplot(df_vars, aes(x = vars, y = value, fill = factor(component))) +
         axis.text.y = element_text(size = 14),
         axis.title.y = element_text(size = 14))
 ggsave("results/rank_plots/rank_vars.pdf", width = 10, height = 7)
+ggsave("results/rank_plots/rank_vars.png", width = 10, height = 7, dpi = 300)
 

From d6eda291cbaa4f56e6593d674599490fc3db2e69 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 9 May 2023 16:40:31 -0300
Subject: [PATCH 11/24] chore: save upset plots as png

---
 scripts/intersection_analysis.R | 28 ++++++++++++++++++++++++++++
 1 file changed, 28 insertions(+)

diff --git a/scripts/intersection_analysis.R b/scripts/intersection_analysis.R
index b55520c..f49c9ef 100644
--- a/scripts/intersection_analysis.R
+++ b/scripts/intersection_analysis.R
@@ -22,19 +22,37 @@ l_type <- lapply(split(diff_df$gene, diff_df$type), unique)
 upset(fromList(l_type), text.scale = c(1.5, 2, 1, 1.5, 2, 3), point.size = 5, nintersects = NA)
 dev.off()
 
+png("results/intersects/genes_by_type.png",  width = 20, height = 14, units = "cm", res = 300)
+l_type <- lapply(split(diff_df$gene, diff_df$type), unique)
+upset(fromList(l_type), text.scale = c(1.5, 2, 1, 1.5, 2, 3), point.size = 5, nintersects = NA)
+dev.off()
+
 # By groups in each sex 
+
+# Female
 pdf("results/intersects/genes_by_group_female.pdf", height = 7, width = 15)
 l_group_female <- lapply(split(diff_df$gene[diff_df$sex == "female"], diff_df$group[diff_df$sex == "female"]), unique)
 upset(fromList(l_group_female), nsets = length(l_group_female),  text.scale = c(1.5, 1.5, 1, 1, 2, 2), 
       point.size = 3, nintersects = NA)
 dev.off()
 
+png("results/intersects/genes_by_group_female.png",  width = 20, height = 14, units = "cm", res = 300)
+upset(fromList(l_group_female), nsets = length(l_group_female),  text.scale = c(1.5, 1.5, 1, 1, 2, 2), 
+      point.size = 3, nintersects = NA)
+dev.off()
+
+# Male
 pdf("results/intersects/genes_by_group_male.pdf", height = 7, width = 15)
 l_group_male <- lapply(split(diff_df$gene[diff_df$sex == "male"], diff_df$group[diff_df$sex == "male"]), unique)
 upset(fromList(l_group_male), nsets = length(l_group_male), text.scale = c(1.5, 1.5, 1, 1, 2, 2), 
       point.size = 3, nintersects = NA)
 dev.off()
 
+png("results/intersects/genes_by_group_male.png",  width = 20, height = 14, units = "cm", res = 300)
+upset(fromList(l_group_male), nsets = length(l_group_male),  text.scale = c(1.5, 1.5, 1, 1, 2, 2), 
+      point.size = 3, nintersects = NA)
+dev.off()
+
 # By regions
 pdf("results/intersects/genes_by_regions.pdf", height = 7, width = 15)
 l_regions <- lapply(split(diff_df$gene, diff_df$region), unique)
@@ -42,12 +60,22 @@ upset(fromList(l_regions), nsets = length(l_regions), text.scale = c(1.5, 1.5, 1
       point.size = 3, nintersects = NA)
 dev.off()
 
+png("results/intersects/genes_by_region.png",  width = 20, height = 14, units = "cm", res = 300)
+upset(fromList(l_regions), nsets = length(l_regions),  text.scale = c(1.5, 1.5, 1, 1, 2, 2), 
+      point.size = 3, nintersects = NA)
+dev.off()
+
 # By sex
 pdf("results/intersects/genes_by_sex.pdf", height = 5, width = 10)
 l_sex <- lapply(split(diff_df$gene, diff_df$sex), unique)
 upset(fromList(l_sex), nsets = length(l_sex), text.scale = c(1.5, 2, 1, 1.5, 2, 3))
 dev.off()
 
+png("results/intersects/genes_by_sex.png",  width = 20, height = 14, units = "cm", res = 300)
+upset(fromList(l_sex), nsets = length(l_sex),  text.scale = c(1.5, 1.5, 1, 1, 2, 2), 
+      point.size = 3, nintersects = NA)
+dev.off()
+
 # Get the list of genes for each intersection
 get_intersect_genes <- function(ls) {
   tmp <- gplots::venn(ls, show.plot = F)

From 272bcfe179109dba3bcddb6e341ccc4059b71ac1 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 9 May 2023 16:42:37 -0300
Subject: [PATCH 12/24] chore: added chisq.test and fisher.test to biotype
 categories

---
 scripts/summarise_biotypes.R | 124 ++++++++++++++++++++++++++---------
 1 file changed, 94 insertions(+), 30 deletions(-)

diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index b000aef..b73b05d 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -24,7 +24,9 @@ dge_w_biotype <- gtf_data[, c("gene_id", "gene_biotype")] %>%
   dplyr::select(gene_id, gene_biotype) %>%
   right_join(dge_genes, by = c("gene_id" = "gene")) %>%
   distinct() %>% 
-  dplyr::select(gene_id, gene_biotype, group)
+  dplyr::select(gene_id, gene_biotype, group) %>% 
+  dplyr::rename(biotype = gene_biotype) %>% 
+  mutate(type = "DGE")
 
 readr::write_csv(dge_w_biotype, "results/diff_exp/dge_w_biotype.csv")
 
@@ -42,58 +44,47 @@ dte_w_biotype <-
   dplyr::select(transcript_id, transcript_biotype) %>%
   right_join(dte_genes, by = c("transcript_id" = "txID")) %>%
   distinct() %>% 
-  dplyr::select(transcript_id, transcript_biotype, group)
+  dplyr::select(transcript_id, transcript_biotype, group) %>% 
+  dplyr::rename(biotype = transcript_biotype) %>% 
+  mutate(type = "DTE")
 
 readr::write_csv(dte_w_biotype, "results/diff_exp/dte_w_biotype.csv")
  
 # 2.3. Get DTU biotypes ---------------------------------------------
 
 dtu_w_biotype <- readr::read_csv("results/ISA/dtu_w_biotype.csv")
+dtu_w_biotype <- dtu_w_biotype %>% 
+  dplyr::rename(biotype = iso_biotype) %>% 
+  mutate(type = "DTU")
 
-# Plot  ---------------------------------------
-plot_biotype_bar <- function(data, id_col, n_col, color) {
-  
-  id_col <- enquo(id_col)
-  n_col <- enquo(n_col)
-  
-  data %>% 
-    ggplot(aes(x = reorder(!!id_col, dplyr::desc(!!n_col)), y = !!n_col)) +
-    geom_col(fill = color) + 
-    scale_y_continuous(labels = scales::percent_format(scale = 1), name = "", limits = c(0, 100)) +
-    coord_flip() +
-    theme_bw() +
-    theme(panel.grid.minor = element_blank(),
-          plot.margin = margin(-1, 0, -1, 0))
-}
+
+# Plot for both sexes -----------------------------------------------------
 
 dge_plot <- dge_w_biotype %>% 
-  group_by(gene_biotype) %>% 
+  group_by(biotype) %>% 
   summarise(biotype_n = n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
   ungroup() %>% 
-  mutate(type = "DGE") %>% 
-  dplyr::rename(biotype = gene_biotype)
+  mutate(type = "DGE")
 
 dte_plot <- dte_w_biotype %>%
-  group_by(transcript_biotype) %>%
+  group_by(biotype) %>%
   summarise(biotype_n = n() / length(unique(dte_w_biotype$transcript_id))* 100) %>%
-  ungroup() %>%
-  mutate(type = "DTE") %>% 
-  dplyr::rename(biotype = transcript_biotype)
+  ungroup() %>% 
+  mutate(type = "DTE")
 
 dtu_plot <- dtu_w_biotype %>%
-  group_by(iso_biotype) %>%
+  group_by(biotype) %>%
   summarise(biotype_n = n() / length(unique(dtu_w_biotype$isoform_id))* 100) %>%
-  ungroup() %>%
-  mutate(type = "DTU") %>%
-  dplyr::rename(biotype = iso_biotype)
+  ungroup() %>% 
+  mutate(type = "DTU")
 
 df_plot <- Reduce(bind_rows, list(dge_plot, dte_plot, dtu_plot))
 df_plot$biotype <- gsub("_", " ", df_plot$biotype)
 
 # Plot feature biotypes
-
 color_scale <- c("DGE" = "#0ac80aff", "DTE" = "#4f4affff", "DTU" = "#ff822fff")
 
+# Female and male together
 ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(biotype_n)), y = biotype_n, fill = type)) +
   geom_col(show.legend = F) + 
   scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
@@ -104,7 +95,80 @@ ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(biotype_n)), y = biotype_n,
   theme_bw() +
   theme(panel.grid.minor = element_blank()) -> biotype_plot
 
-
 # Save
 ggsave(biotype_plot, file = "results/plots_paper/biotype_plot.pdf", width = 7, height = 4)
 
+
+# Plot for feature types for each sex -------------------------------------
+
+dge_plot <- dge_w_biotype %>% 
+  separate(group, into = c("region", "sex")) %>% 
+  group_by(biotype, sex) %>% 
+  summarise(biotype_n = n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
+  ungroup() %>% 
+  mutate(type = "DGE")
+
+dte_plot <- dte_w_biotype %>% 
+  separate(group, into = c("region", "sex")) %>% 
+  group_by(biotype, sex) %>% 
+  summarise(biotype_n = n() / length(unique(dte_w_biotype$transcript_id)) * 100) %>% 
+  ungroup() %>% 
+  mutate(type = "DTE")
+
+dtu_plot <- dtu_w_biotype %>% 
+  separate(group, into = c("region", "sex")) %>% 
+  group_by(biotype, sex) %>% 
+  summarise(biotype_n = n() / length(unique(dtu_w_biotype$isoform_id)) * 100) %>% 
+  ungroup() %>% 
+  mutate(type = "DTU")
+
+df_plot <- Reduce(bind_rows, list(dge_plot, dte_plot, dtu_plot))
+df_plot$biotype <- gsub("_", " ", df_plot$biotype)
+
+# Plot feature biotypes
+color_scale <- c("DGE" = "#0ac80aff", "DTE" = "#4f4affff", "DTU" = "#ff822fff")
+
+# Female and male together
+ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(biotype_n)), y = biotype_n, fill = type)) +
+  geom_col(show.legend = F) + 
+  scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
+  facet_grid(rows = vars(type), cols = vars(sex), scales = "free_y",
+             labeller = labeller(sex = as_labeller(c("female" = "Female", "male" = "Male")))) +
+  scale_fill_manual(values = color_scale) + 
+  labs(x = "Feature biotypes", y = "% of feature biotype by the total features") +
+  coord_flip() +
+  theme_bw() +
+  theme(panel.grid = element_blank()) -> biotype_plot_by_sex
+
+# Save
+ggsave(biotype_plot_by_sex, filename = "results/plots_paper/biotype_by_sexplot.pdf", width = 7, height = 4)
+
+# Test feature prevalence differences between female and male -------------
+
+biotypes_by_sex <- Reduce(bind_rows, list(
+  dge_w_biotype %>% dplyr::select(-gene_id), 
+  dte_w_biotype %>% dplyr::select(-transcript_id), 
+  dtu_w_biotype %>% dplyr::select(-isoform_id)))
+
+biotypes_by_sex %>% 
+  separate(group, into = c("region", "sex"), sep = "_") %>% 
+  arrange(type, biotype) %>% 
+  group_by(type) %>% 
+  group_map(~ {
+    cat(.y$type, sep = "\n")
+    cont_table <- table(.x$biotype, .x$sex)
+    return(fisher.test(cont_table))
+  }) -> biot_tests_fisher
+
+biotypes_by_sex %>% 
+  separate(group, into = c("region", "sex"), sep = "_") %>% 
+  arrange(type, biotype) %>% 
+  group_by(type) %>% 
+  group_map(~ {
+    cat(.y$type, sep = "\n")
+    cont_table <- table(.x$biotype, .x$sex)
+    return(chisq.test(cont_table))
+  }) -> biot_tests_chisq
+
+names(biot_tests_fisher) <- c("DGE", "DTE", "DTU")
+names(biot_tests_chisq) <- c("DGE", "DTE", "DTU")

From 727ac581ac06b7ae1e9ba35a8de155a54934e834 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Fri, 12 May 2023 19:54:49 -0300
Subject: [PATCH 13/24] feat: add networks by groups

---
 scripts/network_groups.R | 116 +++++++++++++++++++++++++++++++++++++++
 1 file changed, 116 insertions(+)
 create mode 100644 scripts/network_groups.R

diff --git a/scripts/network_groups.R b/scripts/network_groups.R
new file mode 100644
index 0000000..e72f4e3
--- /dev/null
+++ b/scripts/network_groups.R
@@ -0,0 +1,116 @@
+
+# Create individual networks ----------------------------------------------
+
+genes <- c("HNRNPA3", "DDX39B")
+i <- "aINS_female"
+
+diff_df_temp <- diff_df %>% 
+  select(hgnc_symbol, type) %>% 
+  filter(hgnc_symbol %in% genes) %>% 
+  distinct()
+
+int_temp <- int %>% 
+  filter(preferredName_A %in% diff_df_temp$hgnc_symbol, preferredName_B %in% diff_df_temp$hgnc_symbol)
+
+g <- graph_from_edgelist(as.matrix(int_temp[,c(1,2)]))
+
+lay <- create_layout(g, layout = "nicely")
+V(g)$x <- lay[,"x"]
+V(g)$y <- lay[,"y"]
+V(g)$a <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DGE"]), 1, 0)
+V(g)$b <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTE"]), 1, 0)
+V(g)$c <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTU"]), 1, 0)
+
+ggraph(g, x = x, y = y) +
+  geom_edge_link0(edge_color = "gray", alpha = 0.7, width = 0.2) +
+  geom_scatterpie(
+    data = as_data_frame(g, "vertices"),
+    cols = c("a", "b", "c"),
+    color = NA,
+    pie_scale = 4,
+    show.legend = F) +
+  geom_node_text(aes(label = name), size = 3,  nudge_x = 0.03, nudge_y = 0.03) + 
+  scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
+  coord_fixed() + 
+  theme_graph() 
+
+
+
+# -------------------------------------------------------------------------
+
+load("results/networks/graphs_by_group_wo_nbor.rda")
+
+make_graph_by_group <- function(genes, group_name, diff_df, int) {
+  
+  if(!is.null(genes)) {
+    
+    diff_df_temp <- diff_df %>% 
+      select(hgnc_symbol, type, group) %>% 
+      filter(hgnc_symbol %in% genes, group %in% group_name) %>% 
+      distinct()
+    
+    int_temp <- int %>% 
+      filter(preferredName_A %in% diff_df_temp$hgnc_symbol, preferredName_B %in% diff_df_temp$hgnc_symbol)
+    
+    g <- graph_from_edgelist(as.matrix(int_temp[,c(1,2)]))
+    
+    lay <- create_layout(g, layout = "nicely")
+    V(g)$x <- lay[,"x"]
+    V(g)$y <- lay[,"y"]
+    V(g)$a <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DGE"]), 1, 0)
+    V(g)$b <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTE"]), 1, 0)
+    V(g)$c <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTU"]), 1, 0)
+    
+    # buffer <- c(-2, 2)
+    # xlims <- ceiling(range(V(g)$x)) + buffer
+    # ylims <- ceiling(range(V(g)$y)) + buffer
+    
+    xlims <- ylims <- c(-50, 50)
+    
+    ggraph(g, x = x, y = y) +
+      geom_edge_link0(edge_color = "gray", alpha = 0.7, width = 0.2) +
+      geom_scatterpie(
+        data = as_data_frame(g, "vertices"),
+        cols = c("a", "b", "c"),
+        color = NA,
+        pie_scale = 0.5,
+        show.legend = F) +
+      geom_node_text(aes(label = name), size = 2,  nudge_x = 0.03, nudge_y = 0.03) + 
+      scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
+      coord_fixed() +
+      scale_x_continuous(limits = xlims) +
+      scale_y_continuous(limits = ylims) +
+      theme_graph() +
+      theme(
+        panel.border = element_rect(
+          colour = "#161616",
+          fill = NA,
+          linewidth = 1
+        )
+      ) -> plot_g
+    
+    return(plot_g)
+    
+  } else {
+    
+    return(NULL)
+  
+  }
+  
+}
+
+imap(graphs_by_group, ~ {
+  
+  make_graph_by_group(.x$genes_from_graph, .y, diff_df, int)
+
+}) %>% 
+  discard(is.null) -> ls_graphs
+
+design <- "ABCDEFGH"
+
+wrap_plots(
+  ls_graphs,
+  design = design,
+  nrow = 2,
+  ncol = 4
+)

From 6022dc7aba291b6b68973bf037fc7db5028c20f0 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Mon, 15 May 2023 09:38:48 -0300
Subject: [PATCH 14/24] fix: added packages to the renv project

---
 renv.lock                    | 472 +++++++++++++++++++++++++++++------
 scripts/gwas_intersections.R |   6 +-
 scripts/plots.rmd            |   2 +-
 scripts/teste                | 125 ----------
 4 files changed, 397 insertions(+), 208 deletions(-)
 delete mode 100644 scripts/teste

diff --git a/renv.lock b/renv.lock
index 5e7a305..ff44fe9 100644
--- a/renv.lock
+++ b/renv.lock
@@ -232,6 +232,30 @@
         "crayon"
       ]
     },
+    "ComplexHeatmap": {
+      "Package": "ComplexHeatmap",
+      "Version": "2.10.0",
+      "Source": "Bioconductor",
+      "git_url": "https://git.bioconductor.org/packages/ComplexHeatmap",
+      "git_branch": "RELEASE_3_14",
+      "git_last_commit": "170df82",
+      "git_last_commit_date": "2021-10-26",
+      "Hash": "964941c376127a2eccfb0d89d43442d2",
+      "Requirements": [
+        "GetoptLong",
+        "GlobalOptions",
+        "IRanges",
+        "RColorBrewer",
+        "circlize",
+        "clue",
+        "colorspace",
+        "digest",
+        "doParallel",
+        "foreach",
+        "matrixStats",
+        "png"
+      ]
+    },
     "DBI": {
       "Package": "DBI",
       "Version": "1.1.2",
@@ -518,6 +542,26 @@
         "XVector"
       ]
     },
+    "GetoptLong": {
+      "Package": "GetoptLong",
+      "Version": "1.0.5",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "61fac01c73abf03ac72e88dc3952c1e3",
+      "Requirements": [
+        "GlobalOptions",
+        "crayon",
+        "rjson"
+      ]
+    },
+    "GlobalOptions": {
+      "Package": "GlobalOptions",
+      "Version": "0.1.2",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "c3f7b221e60c28f5f3533d74c6fef024",
+      "Requirements": []
+    },
     "HDInterval": {
       "Package": "HDInterval",
       "Version": "0.2.2",
@@ -737,10 +781,10 @@
     },
     "Rcpp": {
       "Package": "Rcpp",
-      "Version": "1.0.7",
+      "Version": "1.0.10",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "dab19adae4440ae55aa8a9d238b246bb",
+      "Hash": "e749cae40fa9ef469b6050959517453c",
       "Requirements": []
     },
     "RcppArmadillo": {
@@ -766,10 +810,10 @@
     },
     "RcppParallel": {
       "Package": "RcppParallel",
-      "Version": "5.1.5",
+      "Version": "5.1.7",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "f3e94e34ff656a7c8336ce01207bc2b8",
+      "Hash": "a45594a00f5dbb073d5ec9f48592a08a",
       "Requirements": []
     },
     "RedeR": {
@@ -1196,19 +1240,27 @@
       "Hash": "0baa960e3b49c6176a4f42addcbacc59",
       "Requirements": []
     },
+    "brio": {
+      "Package": "brio",
+      "Version": "1.1.3",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "976cf154dfb043c012d87cddd8bca363",
+      "Requirements": []
+    },
     "broom": {
       "Package": "broom",
-      "Version": "0.7.11",
+      "Version": "1.0.4",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "e4487657db580ae1fe0f85237a88ff1f",
+      "Hash": "f62b2504021369a2449c54bbda362d30",
       "Requirements": [
         "backports",
         "dplyr",
         "ellipsis",
         "generics",
-        "ggplot2",
         "glue",
+        "lifecycle",
         "purrr",
         "rlang",
         "stringr",
@@ -1330,6 +1382,18 @@
         "backports"
       ]
     },
+    "circlize": {
+      "Package": "circlize",
+      "Version": "0.4.15",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "2bb47a2fe6ab009b1dcc5566d8c3a988",
+      "Requirements": [
+        "GlobalOptions",
+        "colorspace",
+        "shape"
+      ]
+    },
     "class": {
       "Package": "class",
       "Version": "7.3-19",
@@ -1356,6 +1420,37 @@
       "Hash": "ebaa97ac99cc2daf04e77eecc7b781d7",
       "Requirements": []
     },
+    "clock": {
+      "Package": "clock",
+      "Version": "0.6.1",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "db6b0e88fa092982ecf56322b47be0fe",
+      "Requirements": [
+        "cpp11",
+        "rlang",
+        "tzdb",
+        "vctrs"
+      ]
+    },
+    "clue": {
+      "Package": "clue",
+      "Version": "0.3-64",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "f013e45eb656a4bb17b39cb24827a51f",
+      "Requirements": [
+        "cluster"
+      ]
+    },
+    "cluster": {
+      "Package": "cluster",
+      "Version": "2.1.4",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "5edbbabab6ce0bf7900a74fd4358628e",
+      "Requirements": []
+    },
     "clusterProfiler": {
       "Package": "clusterProfiler",
       "Version": "4.2.1",
@@ -1415,6 +1510,14 @@
       "Hash": "0f22be39ec1d141fd03683c06f3a6e67",
       "Requirements": []
     },
+    "concatenate": {
+      "Package": "concatenate",
+      "Version": "1.0.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "94b165d30bf16386c2f096409d502463",
+      "Requirements": []
+    },
     "conquer": {
       "Package": "conquer",
       "Version": "1.2.1",
@@ -1531,6 +1634,16 @@
       "Hash": "fe1a3788cf243db3eca07ae661860793",
       "Requirements": []
     },
+    "diffobj": {
+      "Package": "diffobj",
+      "Version": "0.3.5",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "bcaa8b95f8d7d01a5dedfd959ce88ab8",
+      "Requirements": [
+        "crayon"
+      ]
+    },
     "digest": {
       "Package": "digest",
       "Version": "0.6.29",
@@ -1591,13 +1704,13 @@
     },
     "dplyr": {
       "Package": "dplyr",
-      "Version": "1.0.7",
+      "Version": "1.1.2",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "36f1ae62f026c8ba9f9b5c9a08c03297",
+      "Hash": "dea6970ff715ca541c387de363ff405e",
       "Requirements": [
         "R6",
-        "ellipsis",
+        "cli",
         "generics",
         "glue",
         "lifecycle",
@@ -1651,6 +1764,19 @@
         "proxy"
       ]
     },
+    "easylayout": {
+      "Package": "easylayout",
+      "Version": "0.1.0",
+      "Source": "GitHub",
+      "RemoteType": "github",
+      "RemoteHost": "api.github.com",
+      "RemoteRepo": "easylayout",
+      "RemoteUsername": "daniloimparato",
+      "RemoteRef": "dadamorais",
+      "RemoteSha": "fdb800aec4852dddcdaec11a4bae1dc1c5d770b9",
+      "Hash": "555092182283a7b6537406811f0053a6",
+      "Requirements": []
+    },
     "edgeR": {
       "Package": "edgeR",
       "Version": "3.36.0",
@@ -1991,10 +2117,10 @@
     },
     "generics": {
       "Package": "generics",
-      "Version": "0.1.1",
+      "Version": "0.1.3",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "3f6bcfb0ee5d671d9fd1893d2faa79cb",
+      "Hash": "15e9634c0fcd294799e9b2e929ed1b86",
       "Requirements": []
     },
     "ggdist": {
@@ -2073,20 +2199,22 @@
     },
     "ggplot2": {
       "Package": "ggplot2",
-      "Version": "3.3.5",
+      "Version": "3.4.2",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "d7566c471c7b17e095dd023b9ef155ad",
+      "Hash": "3a147ee02e85a8941aad9909f1b43b7b",
       "Requirements": [
         "MASS",
-        "digest",
+        "cli",
         "glue",
         "gtable",
         "isoband",
+        "lifecycle",
         "mgcv",
         "rlang",
         "scales",
         "tibble",
+        "vctrs",
         "withr"
       ]
     },
@@ -2189,10 +2317,10 @@
     },
     "glue": {
       "Package": "glue",
-      "Version": "1.6.0",
+      "Version": "1.6.2",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "b8bb7aaf248e45bac08ebed86f3a0aa4",
+      "Hash": "4f2596dfb05dac67b9dc558e5c6fba2e",
       "Requirements": []
     },
     "googledrive": {
@@ -2307,6 +2435,47 @@
       "Hash": "2ace6c4a06297d0b364e0444384a2b82",
       "Requirements": []
     },
+    "gwasrapidd": {
+      "Package": "gwasrapidd",
+      "Version": "0.99.12",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "56be6fbe33e1892fea54591d36881510",
+      "Requirements": [
+        "assertthat",
+        "concatenate",
+        "dplyr",
+        "glue",
+        "httr",
+        "jsonlite",
+        "lubridate",
+        "magrittr",
+        "pingr",
+        "plyr",
+        "progress",
+        "purrr",
+        "rlang",
+        "stringr",
+        "testthat",
+        "tibble",
+        "tidyr",
+        "urltools"
+      ]
+    },
+    "hardhat": {
+      "Package": "hardhat",
+      "Version": "1.3.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "b56b42c50bb7c76a683e8e61f415d828",
+      "Requirements": [
+        "cli",
+        "glue",
+        "rlang",
+        "tibble",
+        "vctrs"
+      ]
+    },
     "haven": {
       "Package": "haven",
       "Version": "2.4.3",
@@ -2495,6 +2664,27 @@
       "Hash": "64778782a89480e9a644f69aad9a2877",
       "Requirements": []
     },
+    "janitor": {
+      "Package": "janitor",
+      "Version": "2.2.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "5baae149f1082f466df9d1442ba7aa65",
+      "Requirements": [
+        "dplyr",
+        "hms",
+        "lifecycle",
+        "lubridate",
+        "magrittr",
+        "purrr",
+        "rlang",
+        "snakecase",
+        "stringi",
+        "stringr",
+        "tidyr",
+        "tidyselect"
+      ]
+    },
     "jquerylib": {
       "Package": "jquerylib",
       "Version": "0.1.4",
@@ -2599,11 +2789,12 @@
     },
     "lifecycle": {
       "Package": "lifecycle",
-      "Version": "1.0.1",
+      "Version": "1.0.3",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "a6b6d352e3ed897373ab19d8395c98d0",
+      "Hash": "001cecbeac1cff9301bdc3775ee46a86",
       "Requirements": [
+        "cli",
         "glue",
         "rlang"
       ]
@@ -2870,6 +3061,18 @@
         "askpass"
       ]
     },
+    "openxlsx": {
+      "Package": "openxlsx",
+      "Version": "4.2.5.2",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "c03b4c18d42da881fb8e15a085c2b9d6",
+      "Requirements": [
+        "Rcpp",
+        "stringi",
+        "zip"
+      ]
+    },
     "org.Hs.eg.db": {
       "Package": "org.Hs.eg.db",
       "Version": "3.14.0",
@@ -2963,21 +3166,30 @@
     },
     "pillar": {
       "Package": "pillar",
-      "Version": "1.6.4",
+      "Version": "1.9.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "60200b6aa32314ac457d3efbb5ccbd98",
+      "Hash": "15da5a8412f317beeee6175fbc76f4bb",
       "Requirements": [
         "cli",
-        "crayon",
-        "ellipsis",
         "fansi",
+        "glue",
         "lifecycle",
         "rlang",
         "utf8",
         "vctrs"
       ]
     },
+    "pingr": {
+      "Package": "pingr",
+      "Version": "2.0.1",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "e293e79be42ffd336d938937fd3017fb",
+      "Requirements": [
+        "processx"
+      ]
+    },
     "pkgbuild": {
       "Package": "pkgbuild",
       "Version": "1.3.1",
@@ -3003,6 +3215,23 @@
       "Hash": "01f28d4278f15c76cddbea05899c5d6f",
       "Requirements": []
     },
+    "pkgload": {
+      "Package": "pkgload",
+      "Version": "1.3.2",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "6b0c222c5071efe0f3baf3dae9aa40e2",
+      "Requirements": [
+        "cli",
+        "crayon",
+        "desc",
+        "fs",
+        "glue",
+        "rlang",
+        "rprojroot",
+        "withr"
+      ]
+    },
     "plogr": {
       "Package": "plogr",
       "Version": "0.2.0",
@@ -3087,6 +3316,14 @@
         "tidyr"
       ]
     },
+    "praise": {
+      "Package": "praise",
+      "Version": "1.0.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "a555924add98c99d2f411e37e7d25e9f",
+      "Requirements": []
+    },
     "prettyunits": {
       "Package": "prettyunits",
       "Version": "1.1.1",
@@ -3174,13 +3411,16 @@
     },
     "purrr": {
       "Package": "purrr",
-      "Version": "0.3.4",
+      "Version": "1.0.1",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "97def703420c8ab10d8f0e6c72101e02",
+      "Hash": "d71c815267c640f17ddbf7f16144b4bb",
       "Requirements": [
+        "cli",
+        "lifecycle",
         "magrittr",
-        "rlang"
+        "rlang",
+        "vctrs"
       ]
     },
     "quadprog": {
@@ -3218,14 +3458,6 @@
         "reshape2"
       ]
     },
-    "rJava": {
-      "Package": "rJava",
-      "Version": "1.0-6",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "0415819f6baa75d86d52483f7292b623",
-      "Requirements": []
-    },
     "ranger": {
       "Package": "ranger",
       "Version": "0.13.1",
@@ -3281,17 +3513,20 @@
     },
     "recipes": {
       "Package": "recipes",
-      "Version": "0.1.17",
+      "Version": "1.0.6",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "443951ef5d9e72a96405cbb0157bb1d4",
+      "Hash": "eb53ffc9674dc9a52c3a7e22d96d3f56",
       "Requirements": [
         "Matrix",
+        "cli",
+        "clock",
         "dplyr",
         "ellipsis",
         "generics",
         "glue",
         "gower",
+        "hardhat",
         "ipred",
         "lifecycle",
         "lubridate",
@@ -3483,10 +3718,10 @@
     },
     "rstudioapi": {
       "Package": "rstudioapi",
-      "Version": "0.13",
+      "Version": "0.14",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "06c85365a03fdaf699966cc1d3cf53ea",
+      "Hash": "690bd2acc42a9166ce34845884459320",
       "Requirements": []
     },
     "rsvd": {
@@ -3557,10 +3792,10 @@
     },
     "scales": {
       "Package": "scales",
-      "Version": "1.1.1",
+      "Version": "1.2.1",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "6f76f71042411426ec8df6c54f34e6dd",
+      "Hash": "906cb23d2f1c5680b8ce439b44c6fa63",
       "Requirements": [
         "R6",
         "RColorBrewer",
@@ -3568,6 +3803,7 @@
         "labeling",
         "lifecycle",
         "munsell",
+        "rlang",
         "viridisLite"
       ]
     },
@@ -3607,6 +3843,14 @@
         "scales"
       ]
     },
+    "shape": {
+      "Package": "shape",
+      "Version": "1.4.6",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "9067f962730f58b14d8ae54ca885509f",
+      "Requirements": []
+    },
     "shiny": {
       "Package": "shiny",
       "Version": "1.7.1",
@@ -3646,6 +3890,17 @@
         "Rcpp"
       ]
     },
+    "snakecase": {
+      "Package": "snakecase",
+      "Version": "0.11.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "4079070fc210c7901c0832a3aeab894f",
+      "Requirements": [
+        "stringi",
+        "stringr"
+      ]
+    },
     "snow": {
       "Package": "snow",
       "Version": "0.4-4",
@@ -3719,14 +3974,18 @@
     },
     "stringr": {
       "Package": "stringr",
-      "Version": "1.4.0",
+      "Version": "1.5.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "0759e6b6c0957edb1311028a49a35e76",
+      "Hash": "671a4d384ae9d32fc47a14e98bfa3dc8",
       "Requirements": [
+        "cli",
         "glue",
+        "lifecycle",
         "magrittr",
-        "stringi"
+        "rlang",
+        "stringi",
+        "vctrs"
       ]
     },
     "survival": {
@@ -3763,14 +4022,40 @@
       "Hash": "fd792ceac77f96b647fa8d6e1788969a",
       "Requirements": []
     },
+    "testthat": {
+      "Package": "testthat",
+      "Version": "3.1.7",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "7eb5fd202a61d2fb78af5869b6c08998",
+      "Requirements": [
+        "R6",
+        "brio",
+        "callr",
+        "cli",
+        "desc",
+        "digest",
+        "ellipsis",
+        "evaluate",
+        "jsonlite",
+        "lifecycle",
+        "magrittr",
+        "pkgload",
+        "praise",
+        "processx",
+        "ps",
+        "rlang",
+        "waldo",
+        "withr"
+      ]
+    },
     "tibble": {
       "Package": "tibble",
-      "Version": "3.1.6",
+      "Version": "3.2.1",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "8a8f02d1934dfd6431c671361510dd0b",
+      "Hash": "a84e2cc86d07289b3b6f5069df7a004c",
       "Requirements": [
-        "ellipsis",
         "fansi",
         "lifecycle",
         "magrittr",
@@ -3822,19 +4107,20 @@
     },
     "tidyr": {
       "Package": "tidyr",
-      "Version": "1.1.4",
+      "Version": "1.3.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "c8fbdbd9fcac223d6c6fe8e406f368e1",
+      "Hash": "e47debdc7ce599b070c8e78e8ac0cfcf",
       "Requirements": [
+        "cli",
         "cpp11",
         "dplyr",
-        "ellipsis",
         "glue",
         "lifecycle",
         "magrittr",
         "purrr",
         "rlang",
+        "stringr",
         "tibble",
         "tidyselect",
         "vctrs"
@@ -3842,16 +4128,17 @@
     },
     "tidyselect": {
       "Package": "tidyselect",
-      "Version": "1.1.1",
+      "Version": "1.2.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "7243004a708d06d4716717fa1ff5b2fe",
+      "Hash": "79540e5fcd9e0435af547d885f184fd5",
       "Requirements": [
-        "ellipsis",
+        "cli",
         "glue",
-        "purrr",
+        "lifecycle",
         "rlang",
-        "vctrs"
+        "vctrs",
+        "withr"
       ]
     },
     "tidytree": {
@@ -3947,6 +4234,16 @@
         "tidytree"
       ]
     },
+    "triebeard": {
+      "Package": "triebeard",
+      "Version": "0.3.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "847a9d113b78baca4a9a8639609ea228",
+      "Requirements": [
+        "Rcpp"
+      ]
+    },
     "tweenr": {
       "Package": "tweenr",
       "Version": "1.0.2",
@@ -4000,14 +4297,25 @@
     },
     "tzdb": {
       "Package": "tzdb",
-      "Version": "0.2.0",
+      "Version": "0.3.0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "5e069fb033daf2317bd628d3100b75c5",
+      "Hash": "b2e1cbce7c903eaf23ec05c58e59fb5e",
       "Requirements": [
         "cpp11"
       ]
     },
+    "urltools": {
+      "Package": "urltools",
+      "Version": "1.7.3",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "e86a704261a105f4703f653e05defa3e",
+      "Requirements": [
+        "Rcpp",
+        "triebeard"
+      ]
+    },
     "utf8": {
       "Package": "utf8",
       "Version": "1.2.2",
@@ -4038,13 +4346,14 @@
     },
     "vctrs": {
       "Package": "vctrs",
-      "Version": "0.3.8",
+      "Version": "0.6.2",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "ecf749a1b39ea72bd9b51b76292261f1",
+      "Hash": "a745bda7aff4734c17294bb41d4e4607",
       "Requirements": [
-        "ellipsis",
+        "cli",
         "glue",
+        "lifecycle",
         "rlang"
       ]
     },
@@ -4091,6 +4400,22 @@
         "withr"
       ]
     },
+    "waldo": {
+      "Package": "waldo",
+      "Version": "0.4.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "035fba89d0c86e2113120f93301b98ad",
+      "Requirements": [
+        "cli",
+        "diffobj",
+        "fansi",
+        "glue",
+        "rematch2",
+        "rlang",
+        "tibble"
+      ]
+    },
     "withr": {
       "Package": "withr",
       "Version": "2.5.0",
@@ -4107,27 +4432,6 @@
       "Hash": "e2e5fb1a74fbb68b27d6efc5372635dc",
       "Requirements": []
     },
-    "xlsx": {
-      "Package": "xlsx",
-      "Version": "0.6.5",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "d24d579f59a3b6da1e1cf4660425443e",
-      "Requirements": [
-        "rJava",
-        "xlsxjars"
-      ]
-    },
-    "xlsxjars": {
-      "Package": "xlsxjars",
-      "Version": "0.6.1",
-      "Source": "Repository",
-      "Repository": "CRAN",
-      "Hash": "4c4b3bc29a916f33f1298dd951133351",
-      "Requirements": [
-        "rJava"
-      ]
-    },
     "xml2": {
       "Package": "xml2",
       "Version": "1.3.3",
@@ -4160,6 +4464,14 @@
       "Hash": "922e11dcf40bb5dfcf3fe5e714d0dc35",
       "Requirements": []
     },
+    "zip": {
+      "Package": "zip",
+      "Version": "2.3.0",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "d98c94dacb7e0efcf83b0a133a705504",
+      "Requirements": []
+    },
     "zlibbioc": {
       "Package": "zlibbioc",
       "Version": "1.40.0",
diff --git a/scripts/gwas_intersections.R b/scripts/gwas_intersections.R
index 91c9733..51f0706 100644
--- a/scripts/gwas_intersections.R
+++ b/scripts/gwas_intersections.R
@@ -3,13 +3,15 @@
 
 library(dplyr)
 library(purrr)
+library(gwasrapidd)
+library(biomaRt)
 
 # Get studies related to 'major depressive disorder' and 'unipolar depression'.
 efo_id <- c(
   unipolar_depression        = "EFO_0003761",
   major_depressive_disorder  = "MONDO_0002009"
 )
-mdd_results <- get_studies(efo_id = efo_id, set_operation = "intersection") 
+mdd_results <- get_studies(efo_id = efo_id, set_operation = "intersection")
 
 mdd_filtered <- mdd_results@publications %>% 
   filter(publication_date > "2018-01-01")
@@ -39,7 +41,7 @@ map_dfr(studies, function(study_id) {
   assoc_2 <- associations@associations %>% 
     dplyr::select(association_id, pvalue, pvalue_description, range, beta_number, beta_direction)
 
-  associations_data <- reduce(list(assoc_1, assoc_2), inner_join, by = "association_id")
+  associations_data <- purrr::reduce(list(assoc_1, assoc_2), inner_join, by = "association_id")
   
   associations_data
 
diff --git a/scripts/plots.rmd b/scripts/plots.rmd
index f469e59..4aceaaf 100644
--- a/scripts/plots.rmd
+++ b/scripts/plots.rmd
@@ -412,7 +412,7 @@ diff_df %>%
     )
 
 ggsave("results/plots_paper/percentage_gt.pdf", height = 5, width = 10, device = cairo_pdf)
-ggsave("results/plots_paper/percentage_gt.png", height = 5, width = 10)
+ggsave("results/plots_paper/percentage_gt.png", height = 5, width = 10, dpi = 300)
 ```
 
 # Supplementary Figure 6
diff --git a/scripts/teste b/scripts/teste
deleted file mode 100644
index 9bd7ec1..0000000
--- a/scripts/teste
+++ /dev/null
@@ -1,125 +0,0 @@
-import feyn
-import pandas as pd
-from sklearn.model_selection import train_test_split
-
-
-def get_train_test_types(dataset, random_seed=1024, target="phenotype_reg"):
-    UNWANTED_COLUMNS_FOR_TRAINING = ["run", "phenotype"]
-    data = dataset[dataset.columns.difference(UNWANTED_COLUMNS_FOR_TRAINING)].dropna()
-
-    # Let's record the categorical data types in our dataset (note features will be treated as numerical by default).
-    stypes = {}
-    for f in data.columns:
-        if data[f].dtype == "object":
-            stypes[f] = "c"
-
-    # Split
-    train, test = train_test_split(
-        data, test_size=0.33, stratify=data[target], random_state=random_seed
-    )
-
-    return train, test, stypes
-
-
-def get_models(
-    training_data, stypes, priors, target="phenotype_reg", epochs=20, random_seed=1024
-):
-
-    ql = feyn.QLattice(random_seed=random_seed)
-    ql.update_priors(priors)
-
-    models = ql.auto_run(
-        data=training_data,
-        output_name=target,
-        kind="classification",
-        stypes=stypes,
-        n_epochs=epochs,
-    )
-
-    return models
-
-
-def save_model(model, train, test, filename):
-    model.plot(train, test, filename=f"results/sym_reg/{filename}_summary.html")
-    model.plot_signal(train, filename=f"results/sym_reg/{filename}_signal.svg")
-    model.save(f"results/sym_reg/{filename}_model.json")
-
-
-# From https://github.com/abzu-ai/QLattice-clinical-omics/blob/main/notebooks/functions.py
-def get_models_table(models, train, test, model_name):
-    model_list = []
-    auc_list_train = []
-    auc_list_test = []
-    bic_list = []
-    accuracy_train = []
-    accuracy_test = []
-    feat_list = []
-    function_list = []
-    loss_list = []
-    i = 0
-    for x in models:
-        model_list.append(str(i))
-        auc_list_train.append(str(x.roc_auc_score(train).round(2)))
-        auc_list_test.append(str(x.roc_auc_score(test).round(2)))
-        accuracy_train.append(str(x.accuracy_score(train).round(2)))
-        accuracy_test.append(str(x.accuracy_score(test).round(2)))
-        bic_list.append(str(x.bic.round(2)))
-        feat_list.append(len(x.features))
-        function_list.append(
-            x.sympify(symbolic_lr=False, symbolic_cat=True, include_weights=False)
-        )
-        loss_list.append(x.loss_value)
-        i += 1
-    df = pd.DataFrame(
-        list(
-            zip(
-                model_list,
-                auc_list_train,
-                auc_list_test,
-                accuracy_train,
-                accuracy_test,
-                bic_list,
-                feat_list,
-                function_list,
-                loss_list,
-            )
-        ),
-        columns=[
-            "Model",
-            "AUC Train",
-            "AUC Test",
-            "Accuracy Train",
-            "Accuracy Test",
-            "BIC",
-            "N. Features",
-            "Functional form",
-            "Loss",
-        ],
-    )
-
-    df.to_csv(f"results/sym_reg/{model_name}_table.csv", index=False)
-
-
-def run_models():
-
-    three_gene_data = pd.read_table("results/sym_reg/selected_genes_for_reg.tsv")
-    full_data = pd.read_table("results/sym_reg/genes_for_reg.tsv")
-
-    threeg_train, threeg_test, threeg_types = get_train_test_types(three_gene_data)
-    full_train, full_test, full_types = get_train_test_types(full_data)
-
-    threeg_priors = feyn.tools.estimate_priors(threeg_train, "phenotype_reg", floor=0.1)
-    full_priors = feyn.tools.estimate_priors(full_train, "phenotype_reg", floor=0.1)
-
-    threeg_models = get_models(threeg_train, threeg_types, threeg_priors)
-    full_models = get_models(full_train, full_types, full_priors)
-
-    get_models_table(threeg_models, threeg_train, threeg_test, "three_gene")
-    get_models_table(full_models, full_train, full_test, "all_genes")
-
-    save_model(threeg_models[0], threeg_train, threeg_test, "three_gene")
-    save_model(full_models[0], full_train, full_test, "all_genes")
-
-
-if __name__ == "__main__":
-    run_models()

From 24a193ac33500989e9172f4189ebe5e9b4d5fbcc Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Mon, 15 May 2023 17:25:43 -0300
Subject: [PATCH 15/24] fix: reorder exclusivity on the Fig. 2C

---
 scripts/plots.rmd | 5 +++--
 1 file changed, 3 insertions(+), 2 deletions(-)

diff --git a/scripts/plots.rmd b/scripts/plots.rmd
index 4aceaaf..1a6e530 100644
--- a/scripts/plots.rmd
+++ b/scripts/plots.rmd
@@ -299,11 +299,12 @@ tmp7 <- data.frame(sex = c("Female", "Male"),
                    xmax = c(1.35,2.35))
 
 df_plot2 <- inner_join(df_plot2, tmp7, by = "sex")
+df_plot2$exclusive <- factor(df_plot2$exclusive, levels = c("4", "3", "2", "Exclusive"))
 
 # Define colors to each intersection
 cols_intersects <- c(
-  "2" = "grey40", 
-  "3" = "grey80", 
+  "2" = "grey80", 
+  "3" = "grey40", 
   "4" = "black",
   "Exclusive" = "#8a0cb1ff"
 )

From cc1588a593653399f555da196e89fcc6305cc985 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Mon, 15 May 2023 17:26:23 -0300
Subject: [PATCH 16/24] feat: added biotype graphs for each sex and region

---
 scripts/summarise_biotypes.R | 65 +++++++++++++++++++++++++++++++++++-
 1 file changed, 64 insertions(+), 1 deletion(-)

diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index b73b05d..71ffefa 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -138,7 +138,8 @@ ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(biotype_n)), y = biotype_n,
   labs(x = "Feature biotypes", y = "% of feature biotype by the total features") +
   coord_flip() +
   theme_bw() +
-  theme(panel.grid = element_blank()) -> biotype_plot_by_sex
+  theme(panel.grid = element_blank(),
+        strip.background = element_rect(fill = "white")) -> biotype_plot_by_sex
 
 # Save
 ggsave(biotype_plot_by_sex, filename = "results/plots_paper/biotype_by_sexplot.pdf", width = 7, height = 4)
@@ -172,3 +173,65 @@ biotypes_by_sex %>%
 
 names(biot_tests_fisher) <- c("DGE", "DTE", "DTU")
 names(biot_tests_chisq) <- c("DGE", "DTE", "DTU")
+
+
+# Check biotypes by region in females -------------------------------------
+
+biotypes_by_sex %>% 
+  separate(group, into = c("region", "sex"), sep = "_") %>% 
+  arrange(type, biotype) %>% 
+  filter(sex == "female") %>%  
+  group_by(region, type) %>% 
+  mutate(n1 = n()) %>% 
+  ungroup() %>% 
+  group_by(biotype, type,region) %>% 
+  mutate(n2 = n(),
+         prop_by_region = (n2 / n1) * 100) %>% 
+  arrange(desc(type), desc(region)) %>% 
+  ungroup() %>% 
+  dplyr::select(biotype, region, type, prop_by_region) %>% 
+  distinct() -> biotypes_female
+
+ggplot(biotypes_female, aes(x = reorder(biotype, dplyr::desc(prop_by_region)), y = prop_by_region, fill = type)) +
+  geom_col(show.legend = F) + 
+  scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
+  facet_grid(rows = vars(region), cols = vars(type), scales = "free_y") +
+  scale_fill_manual(values = color_scale) + 
+  labs(x = "Feature biotypes", y = "% of feature biotype by the total features") +
+  coord_flip() +
+  theme_bw() +
+  theme(panel.grid = element_blank(),
+        strip.background = element_rect(fill = "white")) -> plot_biotypes_female
+
+ggsave(plot_biotypes_female, filename = "results/plots_paper/biotype_female.pdf",  width = 10, height = 7)
+
+
+# Check biotypes by region male -------------------------------------------
+
+biotypes_by_sex %>% 
+  separate(group, into = c("region", "sex"), sep = "_") %>% 
+  arrange(type, biotype) %>% 
+  filter(sex == "male") %>%  
+  group_by(region, type) %>% 
+  mutate(n1 = n()) %>% 
+  ungroup() %>% 
+  group_by(biotype, type,region) %>% 
+  mutate(n2 = n(),
+         prop_by_region = (n2 / n1) * 100) %>% 
+  arrange(desc(type), desc(region)) %>% 
+  ungroup() %>% 
+  dplyr::select(biotype, region, type, prop_by_region) %>% 
+  distinct() -> biotypes_male
+
+ggplot(biotypes_male, aes(x = reorder(biotype, dplyr::desc(prop_by_region)), y = prop_by_region, fill = type)) +
+  geom_col(show.legend = F) + 
+  scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
+  facet_grid(rows = vars(region), cols = vars(type), scales = "free_y") +
+  scale_fill_manual(values = color_scale) + 
+  labs(x = "Feature biotypes", y = "% of feature biotype by the total features") +
+  coord_flip() +
+  theme_bw() +
+  theme(panel.grid = element_blank(),
+        strip.background = element_rect(fill = "white")) -> plot_biotypes_male
+
+ggsave(plot_biotypes_male, filename = "results/plots_paper/biotype_male.pdf",  width = 10, height = 7)

From 3ba38ef75f511719b6c78db78677d6e79296b802 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 16 May 2023 14:45:30 -0300
Subject: [PATCH 17/24] fix: create network by sex and region

---
 scripts/network.R        |   2 +
 scripts/network_groups.R | 163 +++++++++++++++++++++++----------------
 2 files changed, 100 insertions(+), 65 deletions(-)

diff --git a/scripts/network.R b/scripts/network.R
index b73f350..ffde233 100644
--- a/scripts/network.R
+++ b/scripts/network.R
@@ -64,6 +64,8 @@ s_map %>%
   combinescores(evidences = c("escore", "ascore", "dscore"), confLevel = 0.4) %>% 
   unique() -> int
 
+save(int, file = "results/networks/int.rda")
+
 # RedeR
 
 # Here we select proper coordinates to our network
diff --git a/scripts/network_groups.R b/scripts/network_groups.R
index e72f4e3..130d56a 100644
--- a/scripts/network_groups.R
+++ b/scripts/network_groups.R
@@ -1,52 +1,24 @@
 
-# Create individual networks ----------------------------------------------
-
-genes <- c("HNRNPA3", "DDX39B")
-i <- "aINS_female"
-
-diff_df_temp <- diff_df %>% 
-  select(hgnc_symbol, type) %>% 
-  filter(hgnc_symbol %in% genes) %>% 
-  distinct()
-
-int_temp <- int %>% 
-  filter(preferredName_A %in% diff_df_temp$hgnc_symbol, preferredName_B %in% diff_df_temp$hgnc_symbol)
-
-g <- graph_from_edgelist(as.matrix(int_temp[,c(1,2)]))
+library(dplyr)
+library(tidyr)
+library(patchwork)
+library(ggplot2)
+library(ggraph)
 
-lay <- create_layout(g, layout = "nicely")
-V(g)$x <- lay[,"x"]
-V(g)$y <- lay[,"y"]
-V(g)$a <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DGE"]), 1, 0)
-V(g)$b <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTE"]), 1, 0)
-V(g)$c <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTU"]), 1, 0)
 
-ggraph(g, x = x, y = y) +
-  geom_edge_link0(edge_color = "gray", alpha = 0.7, width = 0.2) +
-  geom_scatterpie(
-    data = as_data_frame(g, "vertices"),
-    cols = c("a", "b", "c"),
-    color = NA,
-    pie_scale = 4,
-    show.legend = F) +
-  geom_node_text(aes(label = name), size = 3,  nudge_x = 0.03, nudge_y = 0.03) + 
-  scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
-  coord_fixed() + 
-  theme_graph() 
-
-
-
-# -------------------------------------------------------------------------
+# Create individual networks ----------------------------------------------
 
 load("results/networks/graphs_by_group_wo_nbor.rda")
+load("results/diff_exp/diff_df.rda")
+load("results/networks/int.rda")
 
-make_graph_by_group <- function(genes, group_name, diff_df, int) {
+make_graph_by_group <- function(genes, group_name, diff_df, int, nx = 0.3, ny = 0.3, ps = 0.5) {
   
   if(!is.null(genes)) {
     
     diff_df_temp <- diff_df %>% 
-      select(hgnc_symbol, type, group) %>% 
-      filter(hgnc_symbol %in% genes, group %in% group_name) %>% 
+      dplyr::select(hgnc_symbol, type, group) %>% 
+      dplyr::filter(hgnc_symbol %in% genes, group %in% group_name) %>% 
       distinct()
     
     int_temp <- int %>% 
@@ -54,18 +26,23 @@ make_graph_by_group <- function(genes, group_name, diff_df, int) {
     
     g <- graph_from_edgelist(as.matrix(int_temp[,c(1,2)]))
     
-    lay <- create_layout(g, layout = "nicely")
-    V(g)$x <- lay[,"x"]
-    V(g)$y <- lay[,"y"]
+    # lay <- create_layout(g, layout = "nicely")
+    # V(g)$x <- lay[,"x"]
+    # V(g)$y <- lay[,"y"]
     V(g)$a <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DGE"]), 1, 0)
     V(g)$b <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTE"]), 1, 0)
     V(g)$c <- ifelse(V(g)$name %in% unique(diff_df$hgnc_symbol[diff_df$type == "DTU"]), 1, 0)
     
+    layout <- easylayout::vivagraph(graphs_by_group[[group_name]]$graph, pin_nodes = FALSE)
+    layout <- easylayout::vivagraph(graphs_by_group[[group_name]]$graph, layout = layout, pin_nodes = TRUE, pinned_cols = 10, lcc_margin_left = 500)
+    V(g)$x <- layout[, 1]
+    V(g)$y <- layout[, 2]
+    
     # buffer <- c(-2, 2)
     # xlims <- ceiling(range(V(g)$x)) + buffer
     # ylims <- ceiling(range(V(g)$y)) + buffer
     
-    xlims <- ylims <- c(-50, 50)
+    #xlims <- ylims <- c(-50, 50)
     
     ggraph(g, x = x, y = y) +
       geom_edge_link0(edge_color = "gray", alpha = 0.7, width = 0.2) +
@@ -73,44 +50,100 @@ make_graph_by_group <- function(genes, group_name, diff_df, int) {
         data = as_data_frame(g, "vertices"),
         cols = c("a", "b", "c"),
         color = NA,
-        pie_scale = 0.5,
+        pie_scale = ps,
         show.legend = F) +
-      geom_node_text(aes(label = name), size = 2,  nudge_x = 0.03, nudge_y = 0.03) + 
+      geom_node_text(aes(label = name), size = 1,  nudge_x = nx, nudge_y = ny) + 
       scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
       coord_fixed() +
-      scale_x_continuous(limits = xlims) +
-      scale_y_continuous(limits = ylims) +
-      theme_graph() +
-      theme(
-        panel.border = element_rect(
-          colour = "#161616",
-          fill = NA,
-          linewidth = 1
-        )
-      ) -> plot_g
+      theme_void() +
+      theme(plot.margin = margin(3,1,1.5,3, "cm")) -> plot_g
     
     return(plot_g)
     
   } else {
     
     return(NULL)
-  
+    
   }
   
 }
 
 imap(graphs_by_group, ~ {
   
-  make_graph_by_group(.x$genes_from_graph, .y, diff_df, int)
-
+make_graph_by_group(.x$genes_from_graph, .y, diff_df, int)
+  
 }) %>% 
   discard(is.null) -> ls_graphs
 
-design <- "ABCDEFGH"
 
-wrap_plots(
-  ls_graphs,
-  design = design,
-  nrow = 2,
-  ncol = 4
-)
+design_female <- "
+AB
+CD
+EE
+EE
+"
+
+wrap_plots(ls_graphs[c(1,2,4,5,7)], design = design_female)
+ggsave("results/networks/ppi_female.pdf", height = 10, width = 10)
+
+
+# -------------------------------------------------------------------------
+
+make_graph_by_group(graphs_by_group$aINS_female$genes_from_graph, 
+                    group_name = "aINS_female",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.1, ny = 0.1)
+ggsave(filename = "results/networks/aINS_female.pdf", width = 5, height = 5)
+
+
+make_graph_by_group(graphs_by_group$Cg25_female$genes_from_graph, 
+                    group_name = "Cg25_female",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.1, ny = 0.1)
+ggsave(filename = "results/networks/Cg25_female.pdf", width = 5, height = 5)
+
+make_graph_by_group(graphs_by_group$dlPFC_female$genes_from_graph, 
+                    group_name = "dlPFC_female",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.1, ny = 0.1)
+ggsave(filename = "results/networks/dlPFC_female.pdf", width = 5, height = 5)
+
+make_graph_by_group(graphs_by_group$Nac_female$genes_from_graph, 
+                    group_name = "Nac_female",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.2, ny = 0.2)
+ggsave(filename = "results/networks/Nac_female.pdf", width = 5, height = 5)
+
+make_graph_by_group(graphs_by_group$OFC_female$genes_from_graph, 
+                    group_name = "OFC_female",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.2, ny = 0.2, ps = 0.3)
+ggsave(filename = "results/networks/OFC_female.pdf", width = 14, height = 14)
+
+###
+make_graph_by_group(graphs_by_group$Nac_male$genes_from_graph, 
+                    group_name = "Nac_male",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.2, ny = 0.2)
+ggsave(filename = "results/networks/Nac_male.pdf", width = 5, height = 5)
+
+make_graph_by_group(graphs_by_group$Cg25_male$genes_from_graph, 
+                    group_name = "Cg25_male",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.2, ny = 0.2, ps = 0.3)
+ggsave(filename = "results/networks/Cg25_male.pdf", width = 10, height = 10)
+
+
+make_graph_by_group(graphs_by_group$Sub_male$genes_from_graph, 
+                    group_name = "Sub_male",
+                    diff_df = diff_df,
+                    int = int,
+                    nx = 0.2, ny = 0.2)
+ggsave(filename = "results/networks/Sub_male.pdf", width = 7, height = 7)

From f153bc759ba32330b2a644ce4a791c2421ac7f09 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Wed, 17 May 2023 10:48:52 -0300
Subject: [PATCH 18/24] fix: corrected the proportions calculation for by sex
 plot

---
 scripts/summarise_biotypes.R | 50 +++++++++++++++++++++++++++++-------
 1 file changed, 41 insertions(+), 9 deletions(-)

diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index 71ffefa..a46ca96 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -1,5 +1,6 @@
 library(dplyr)
 library(purrr)
+library(tidyr)
 library(ggplot2)
 library(patchwork)
 library(stringr)
@@ -104,23 +105,29 @@ ggsave(biotype_plot, file = "results/plots_paper/biotype_plot.pdf", width = 7, h
 dge_plot <- dge_w_biotype %>% 
   separate(group, into = c("region", "sex")) %>% 
   group_by(biotype, sex) %>% 
-  summarise(biotype_n = n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
+  summarise(biotype_n = n()) %>% 
   ungroup() %>% 
-  mutate(type = "DGE")
+  group_by(sex) %>% 
+  mutate(prop = biotype_n / sum(biotype_n) * 100,
+         type = "DGE")
 
 dte_plot <- dte_w_biotype %>% 
   separate(group, into = c("region", "sex")) %>% 
   group_by(biotype, sex) %>% 
-  summarise(biotype_n = n() / length(unique(dte_w_biotype$transcript_id)) * 100) %>% 
+  summarise(biotype_n = n()) %>% 
   ungroup() %>% 
-  mutate(type = "DTE")
+  group_by(sex) %>% 
+  mutate(prop = biotype_n / sum(biotype_n) * 100,
+         type = "DTE")
 
 dtu_plot <- dtu_w_biotype %>% 
   separate(group, into = c("region", "sex")) %>% 
   group_by(biotype, sex) %>% 
-  summarise(biotype_n = n() / length(unique(dtu_w_biotype$isoform_id)) * 100) %>% 
+  summarise(biotype_n = n()) %>% 
   ungroup() %>% 
-  mutate(type = "DTU")
+  group_by(sex) %>% 
+  mutate(prop = biotype_n / sum(biotype_n) * 100,
+         type = "DTU")
 
 df_plot <- Reduce(bind_rows, list(dge_plot, dte_plot, dtu_plot))
 df_plot$biotype <- gsub("_", " ", df_plot$biotype)
@@ -129,7 +136,7 @@ df_plot$biotype <- gsub("_", " ", df_plot$biotype)
 color_scale <- c("DGE" = "#0ac80aff", "DTE" = "#4f4affff", "DTU" = "#ff822fff")
 
 # Female and male together
-ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(biotype_n)), y = biotype_n, fill = type)) +
+ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(prop)), y = prop, fill = type)) +
   geom_col(show.legend = F) + 
   scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
   facet_grid(rows = vars(type), cols = vars(sex), scales = "free_y",
@@ -158,7 +165,7 @@ biotypes_by_sex %>%
   group_map(~ {
     cat(.y$type, sep = "\n")
     cont_table <- table(.x$biotype, .x$sex)
-    return(fisher.test(cont_table))
+    return(list(fisher = fisher.test(cont_table), count_table = cont_table))
   }) -> biot_tests_fisher
 
 biotypes_by_sex %>% 
@@ -174,6 +181,31 @@ biotypes_by_sex %>%
 names(biot_tests_fisher) <- c("DGE", "DTE", "DTU")
 names(biot_tests_chisq) <- c("DGE", "DTE", "DTU")
 
+# Divide plot by protein coding and non-coding ----------------------------
+df_plot %>% 
+  mutate(
+    coding = case_when(
+      biotype == "protein coding" ~ "coding",
+      .default = "non-coding"
+  )) %>% 
+  group_by(coding, sex, type) %>% 
+  mutate(prop_coding = sum(prop))  %>%
+  dplyr::select(-biotype_n, -biotype, -prop) %>% 
+  unique() -> df_plot_coding
+
+ggplot(df_plot_coding, aes(x = reorder(coding, dplyr::desc(prop_coding)), y = prop_coding, fill = type)) +
+  geom_col(show.legend = F) + 
+  scale_y_continuous(labels = scales::percent_format(scale = 1), limits = c(0, 100)) +
+  facet_grid(rows = vars(type), cols = vars(sex), scales = "free_y",
+             labeller = labeller(sex = as_labeller(c("female" = "Female", "male" = "Male")))) +
+  scale_fill_manual(values = color_scale) + 
+  labs(x = "Feature biotypes", y = "% of feature biotype by the total features") +
+  coord_flip() +
+  theme_bw() +
+  theme(panel.grid = element_blank(),
+        strip.background = element_rect(fill = "white")) -> biotype_plot_coding
+
+ggsave(biotype_plot_coding, filename = "results/plots_paper/biotype_sex_coding.pdf", width = 7, height = 4)
 
 # Check biotypes by region in females -------------------------------------
 
@@ -184,7 +216,7 @@ biotypes_by_sex %>%
   group_by(region, type) %>% 
   mutate(n1 = n()) %>% 
   ungroup() %>% 
-  group_by(biotype, type,region) %>% 
+  group_by(biotype, type, region) %>% 
   mutate(n2 = n(),
          prop_by_region = (n2 / n1) * 100) %>% 
   arrange(desc(type), desc(region)) %>% 

From bd2c8945c5e5c665e1c31de9768cc249f617722f Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 30 May 2023 11:20:07 -0300
Subject: [PATCH 19/24] fix: added final touch

---
 scripts/summarise_biotypes.R | 3 +++
 1 file changed, 3 insertions(+)

diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index a46ca96..c3aecfd 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -267,3 +267,6 @@ ggplot(biotypes_male, aes(x = reorder(biotype, dplyr::desc(prop_by_region)), y =
         strip.background = element_rect(fill = "white")) -> plot_biotypes_male
 
 ggsave(plot_biotypes_male, filename = "results/plots_paper/biotype_male.pdf",  width = 10, height = 7)
+
+
+# -------------------------------------------------------------------------

From 6f90c81f010de6650580efd0c1ce54add3c24fa3 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Fri, 7 Jul 2023 17:32:00 -0300
Subject: [PATCH 20/24] Added Table 2 (gwas intersections)

---
 scripts/gwas_intersections.R | 10 ++++++++++
 1 file changed, 10 insertions(+)

diff --git a/scripts/gwas_intersections.R b/scripts/gwas_intersections.R
index 51f0706..66daf0a 100644
--- a/scripts/gwas_intersections.R
+++ b/scripts/gwas_intersections.R
@@ -5,6 +5,7 @@ library(dplyr)
 library(purrr)
 library(gwasrapidd)
 library(biomaRt)
+library(tidyr)
 
 # Get studies related to 'major depressive disorder' and 'unipolar depression'.
 efo_id <- c(
@@ -82,3 +83,12 @@ intersection <- inner_join(risk_alleles, diff_df, by = c("ensembl_gene_name" = "
 # Save 
 save(intersection, file = "results/diff_exp/gwas_intersections.rda")
 write.csv(intersection, file = "results/tables/gwas_intersection.csv", row.names = F, quote = F)
+
+# Create Supplementary Table 
+intersection %>% 
+  separate(group, into = c("region", "sex"), sep = "_") %>% 
+  dplyr::select(sex, region, hgnc_symbol, type, variant_id, functional_class, pvalue) %>% 
+  mutate(pvalue = as.character(scales::scientific(pvalue))) %>% 
+  arrange(sex, region) %>% 
+  write.csv("results/tables/table2_gwas.csv", row.names = F, quote = F)
+  

From 4c38efedf6a40e42e7ad1a58e7c368082bd16878 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 24 Oct 2023 13:28:10 -0300
Subject: [PATCH 21/24] fix: modifications after stageR correction

---
 scripts/diff_tx_correct.R    | 14 ++++++-------
 scripts/network.R            | 15 ++++++++------
 scripts/network_layout.R     |  6 ++++++
 scripts/plots.rmd            | 40 +++++++++++++++++-------------------
 scripts/summarise_biotypes.R | 26 +++++++++++------------
 5 files changed, 54 insertions(+), 47 deletions(-)

diff --git a/scripts/diff_tx_correct.R b/scripts/diff_tx_correct.R
index dea68a1..aea757d 100644
--- a/scripts/diff_tx_correct.R
+++ b/scripts/diff_tx_correct.R
@@ -5,7 +5,7 @@ library(stageR)
 library(GenomicFeatures)
 
 # Load TX data from differential expression
-load("results/diff_exp/tx_rin_ph_diff.rda")
+load("results/diff_exp/edger_tx_rin_ph_diff.rda")
 df_res <- df_edger_ph_rin_group_tx
 colnames(df_res)[1] <- "tx"
 
@@ -13,10 +13,10 @@ colnames(df_res)[1] <- "tx"
 df_res$tx <- gsub("\\.+\\d+", "", rownames(df_res))
 
 # Load transcript-gene info -----------------------------------------------
-# gtf <- "data/genome/Homo_sapiens.GRCh38.97.gtf.gz"
-# txdb.filename <- "data/genome/Homo_sapiens.GRCh38.97.gtf.sqlite"
-gtf <- "Homo_sapiens.GRCh38.97.gtf.gz"
-txdb.filename <- "Homo_sapiens.GRCh38.97.gtf.sqlite"
+gtf <- "data/genome/Homo_sapiens.GRCh38.97.gtf.gz"
+txdb.filename <- "data/genome/Homo_sapiens.GRCh38.97.gtf.sqlite"
+#gtf <- "Homo_sapiens.GRCh38.97.gtf.gz"
+#txdb.filename <- "Homo_sapiens.GRCh38.97.gtf.sqlite"
 
 # Load db
 txdb <- loadDb(txdb.filename)
@@ -72,7 +72,7 @@ for (i in 1:length(regions)) {
     
     # Get the corrected values
     padj <- getAdjustedPValues(stageRObj, order = TRUE, onlySignificantGenes = T)
-    padj <- padj[!padj$transcript == 0,]
+    # padj <- padj[!padj$transcript == 0,]
     
     if (nrow(padj) == 0) {
       ls_temp[[j]] <- NULL
@@ -93,7 +93,7 @@ if(!dir.exists("results/diff_exp/")) {
 }
 
 # Save results
-save(df_res_padj, file = "results/diff_exp/diff_tx_corrected.rda")
+save(df_res_padj_tx, file = "results/diff_exp/diff_tx_corrected.rda")
 
 
 
diff --git a/scripts/network.R b/scripts/network.R
index ffde233..886be1b 100644
--- a/scripts/network.R
+++ b/scripts/network.R
@@ -10,7 +10,7 @@ library(ggraph)
 library(magrittr)
 library(RedeR)
 
-# ------------------ GET GENES AND INTERACTIONS -------------------------
+# ------------------ GET GENES AND INTERACTIONS ---------------------------
 # Load diff genes table
 load("results/diff_exp/diff_df.rda")
 gwas_intersections <- read_csv("results/tables/gwas_intersection.csv")
@@ -82,6 +82,9 @@ addGraph(rdp, g)
 nodes <- read_tsv("results/networks/model_nodes.txt")
 edges <- read_delim("results/networks/model_edges.txt")
 
+nodes <- read_tsv("~/model_nodes.txt")
+edges <- read_delim("~/model_edges.txt")
+
 # Import nodes coordinates determined by vivagraph
 layout <- read.csv("results/networks/layout.csv")
 
@@ -115,7 +118,7 @@ ggraph(g, x = x, y = y) +
     pie_scale = 0.2,
     show.legend = F
   ) +
-  geom_node_text(aes(label = alias), size = 1.1, nudge_x = 2, nudge_y = 4) + 
+  geom_node_text(aes(label = alias), size = 0.9, nudge_x = 2, nudge_y = 4) + 
   #geom_node_label(aes(label = alias)) + 
   scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
   coord_fixed() +
@@ -131,7 +134,7 @@ svg(filename = "results/plots_paper/network.svg", height = 10, width = 10)
 print(p)
 dev.off()
 
-# Percentage of total genes in the network: 51,52%%
+# Percentage of total genes in the network: 51,24%
 n_distinct(nodes$alias) / n_distinct(diff_df$hgnc_symbol)
 
 
@@ -226,7 +229,7 @@ set_graph_params <- function(g, dict, f_ls) {
 
 l_groups <- map(split(diff_df$hgnc_symbol, diff_df$group), unique)
 
-graphs_by_group <- imap(l_groups, function(x, i){
+graphs_by_group <- imap(l_groups, function(x, i) {
   
   # CHANGE HERE IF YOU WANT FIRST NEIGHBORS
   # (also remember to change the path)
@@ -241,14 +244,14 @@ graphs_by_group <- imap(l_groups, function(x, i){
   # To set all gene labels, set diff_df instead of diff_temp
   g <- set_graph_params(g, dc, f_ls)
   
-  if(include_first_neighbors){
+  if(include_first_neighbors) {
     colors_list <- V(g)$pie
     degrees <- degree(g,v=V(g))
     filter <- !(paste(colors_list) == "c(1, 0, 0, 0)" & degrees == 1)
     g <- induced_subgraph(g, filter)
   }
   
-  if(length(V(g)$pie.color) != 0){
+  if(length(V(g)$pie.color) != 0) {
     pdf(paste0("results/networks/", i, ".pdf"), width = 10, height = 10)
     plot(g)
     dev.off()
diff --git a/scripts/network_layout.R b/scripts/network_layout.R
index 2f60416..7d90c3a 100644
--- a/scripts/network_layout.R
+++ b/scripts/network_layout.R
@@ -3,6 +3,12 @@
 
 library(easylayout)
 
+# Read igraph data
+load("results/networks/int.rda")
+
+# Create graph
+g <- graph_from_edgelist(as.matrix(int[,1:2]), directed = F)
+
 # Organize main layout
 layout <- easylayout::vivagraph(g)
 
diff --git a/scripts/plots.rmd b/scripts/plots.rmd
index 1a6e530..c79293d 100644
--- a/scripts/plots.rmd
+++ b/scripts/plots.rmd
@@ -62,7 +62,7 @@ diff_df %>%
   ggplot(aes(x = col, y = n, fill = type)) +
   geom_bar(position = "stack", stat = "identity") +
   labs(x = "", y = "Number of transcriptionally altered genes", fill = "") +
-  scale_y_continuous(limits = c(0, 1200), breaks = seq(0, 1200, 200)) + 
+  scale_y_continuous(limits = c(0, 1400), breaks = seq(0, 1400, 200)) + 
   scale_fill_manual(values = color_scale) + 
   theme_classic() + 
   theme(
@@ -152,7 +152,7 @@ df_plot %>%
 ggplot(aes(x = as.numeric(x_axis), y = n, fill = type)) +
   geom_bar(stat = "identity", position = "stack") +
   facet_grid(cols = vars(region)) + 
-  scale_y_continuous(name = "Number of transcriptionally altered genes", limits = c(0, 460), breaks = seq(0, 460, 50), minor_breaks = F) +
+  scale_y_continuous(name = "Number of transcriptionally altered genes", limits = c(0, 500), breaks = seq(0, 500, 50), minor_breaks = F) +
   #facet_zoom(x = x_axis %in% c("Female", "Male", "Intersection")) +
   scale_fill_manual(name = "", values = color_scale) +
   scale_x_continuous("",
@@ -181,7 +181,7 @@ diff_df %>%
   )) -> tmp8
 
 # Create list of genes in female, in male, and in both sexes
-l_genes <- split(tmp8$gene, tmp8$sex)
+l_genes <- split(tmp8$hgnc_symbol, tmp8$sex)
 
 # Plot Venn diagram
 cairo_pdf(file = "results/plots_paper/fig2B.pdf", width = 4, height = 4)
@@ -357,11 +357,8 @@ ggsave("results/plots_paper/fig2C_2.png", height = 4, width = 5, dpi = 300)
 
 ## Figure 3
 
-Enrichment plot was built as described in `enrichment.R` in `script` directory. 
+Figure 3 was produced on the biotype analysis, in the `summarise_biotypes.R` script.
 
-## Figure 4 and 5
-
-Figures 4 and 5 were built as described in `plot_dtu.R` in `script` directory.
 
 # Supplementary Figures
 
@@ -397,14 +394,15 @@ diff_df %>%
   ggplot(aes(x = sex, y = p_gt, fill = gt)) +
     geom_bar(stat = "identity") + 
     facet_grid(.~ region) +
-    scale_y_continuous(breaks = seq(0,1,0.2), 
-                       labels = scales::percent(seq(0,1,0.2))) +
+    scale_y_continuous(breaks = seq(0,1,0.25), 
+                       labels = scales::percent(seq(0,1,0.25))) +
     scale_x_discrete(labels = c("female" = expression("\u2640"), 
                                 "male" = expression("\u2642"))) +
     scale_fill_manual(values = c("G" = "#5E835Fff", "T" = "#85587C"),
                       labels = c("G" = "Genes", "T" = "Transcripts")) + 
     labs(x = "", y = "Pergentage of transcriptionally altered genes", fill = "") + 
     theme_bw() + 
+    geom_hline(yintercept = 0.5, lty = 2, lwd = 0.2) +
     theme(
       strip.background = element_rect(fill = "white"),
       axis.text.x = element_text(size = 15, colour = "black"),
@@ -489,7 +487,7 @@ load("results/important_variables/ann.rda")
 ann %>% 
   rownames_to_column("run") %>% 
   dplyr::select(run, phenotype, gender, region) %>% 
-  count(phenotype, gender, region, name = "number_of_samples") %>% 
+  dplyr::count(phenotype, gender, region, name = "number_of_samples") %>% 
   arrange(gender, region) %>% 
   openxlsx::write.xlsx(file = "results/tables/number_of_samples.xlsx", rowNames = F)
 ```
@@ -504,21 +502,21 @@ diff_df %>%
 ## Supplementary Table 3
 
 ```{r}
-genes_by_group_female %>% 
-  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Female_Intersections")
+wb <- createWorkbook()
+
+addWorksheet(wb, sheetName = "Female_Intersections")
+writeData(wb, sheet = "Female_Intersections", genes_by_group_female)
 
-genes_by_group_male %>% 
-  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Male_Intersections",
-             append = T)
+addWorksheet(wb, sheetName = "Male_Intersections")
+writeData(wb, sheet = "Male_Intersections", genes_by_group_male)
 
-genes_by_sex %>% 
-  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Sex_Intersections",
-             append = T)
+addWorksheet(wb, sheetName = "Sex_Intersections")
+writeData(wb, sheet = "Sex_Intersections", genes_by_sex)
 
-genes_by_regions %>% 
-  openxlsx::write.xlsx(file = "results/tables/intersection_tables.xlsx", row.names = F, sheetName = "Regions_Intersections",
-             append = T)
+addWorksheet(wb, sheetName = "Regions_Intersections")
+writeData(wb, sheet = "Regions_Intersections", genes_by_regions)
 
+saveWorkbook(wb, "results/tables/intersection_tables.xlsx", overwrite = TRUE)
 ```
 
 
diff --git a/scripts/summarise_biotypes.R b/scripts/summarise_biotypes.R
index c3aecfd..e190429 100644
--- a/scripts/summarise_biotypes.R
+++ b/scripts/summarise_biotypes.R
@@ -63,19 +63,19 @@ dtu_w_biotype <- dtu_w_biotype %>%
 
 dge_plot <- dge_w_biotype %>% 
   group_by(biotype) %>% 
-  summarise(biotype_n = n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
+  dplyr::summarise(biotype_n = dplyr::n() / length(unique(dge_w_biotype$gene_id)) * 100) %>% 
   ungroup() %>% 
-  mutate(type = "DGE")
+  dplyr::mutate(type = "DGE")
 
 dte_plot <- dte_w_biotype %>%
   group_by(biotype) %>%
-  summarise(biotype_n = n() / length(unique(dte_w_biotype$transcript_id))* 100) %>%
+  summarise(biotype_n = dplyr::n() / length(unique(dte_w_biotype$transcript_id))* 100) %>%
   ungroup() %>% 
   mutate(type = "DTE")
 
 dtu_plot <- dtu_w_biotype %>%
   group_by(biotype) %>%
-  summarise(biotype_n = n() / length(unique(dtu_w_biotype$isoform_id))* 100) %>%
+  summarise(biotype_n = dplyr::n() / length(unique(dtu_w_biotype$isoform_id))* 100) %>%
   ungroup() %>% 
   mutate(type = "DTU")
 
@@ -105,7 +105,7 @@ ggsave(biotype_plot, file = "results/plots_paper/biotype_plot.pdf", width = 7, h
 dge_plot <- dge_w_biotype %>% 
   separate(group, into = c("region", "sex")) %>% 
   group_by(biotype, sex) %>% 
-  summarise(biotype_n = n()) %>% 
+  summarise(biotype_n = dplyr::n()) %>% 
   ungroup() %>% 
   group_by(sex) %>% 
   mutate(prop = biotype_n / sum(biotype_n) * 100,
@@ -114,7 +114,7 @@ dge_plot <- dge_w_biotype %>%
 dte_plot <- dte_w_biotype %>% 
   separate(group, into = c("region", "sex")) %>% 
   group_by(biotype, sex) %>% 
-  summarise(biotype_n = n()) %>% 
+  summarise(biotype_n = dplyr::n()) %>% 
   ungroup() %>% 
   group_by(sex) %>% 
   mutate(prop = biotype_n / sum(biotype_n) * 100,
@@ -123,7 +123,7 @@ dte_plot <- dte_w_biotype %>%
 dtu_plot <- dtu_w_biotype %>% 
   separate(group, into = c("region", "sex")) %>% 
   group_by(biotype, sex) %>% 
-  summarise(biotype_n = n()) %>% 
+  summarise(biotype_n = dplyr::n()) %>% 
   ungroup() %>% 
   group_by(sex) %>% 
   mutate(prop = biotype_n / sum(biotype_n) * 100,
@@ -149,7 +149,7 @@ ggplot(df_plot, aes(x = reorder(biotype, dplyr::desc(prop)), y = prop, fill = ty
         strip.background = element_rect(fill = "white")) -> biotype_plot_by_sex
 
 # Save
-ggsave(biotype_plot_by_sex, filename = "results/plots_paper/biotype_by_sexplot.pdf", width = 7, height = 4)
+ggsave(biotype_plot_by_sex, filename = "results/plots_paper/fig3.pdf", width = 7, height = 4)
 
 # Test feature prevalence differences between female and male -------------
 
@@ -165,7 +165,7 @@ biotypes_by_sex %>%
   group_map(~ {
     cat(.y$type, sep = "\n")
     cont_table <- table(.x$biotype, .x$sex)
-    return(list(fisher = fisher.test(cont_table), count_table = cont_table))
+    return(list(fisher = fisher.test(cont_table, simulate.p.value = T), count_table = cont_table))
   }) -> biot_tests_fisher
 
 biotypes_by_sex %>% 
@@ -214,10 +214,10 @@ biotypes_by_sex %>%
   arrange(type, biotype) %>% 
   filter(sex == "female") %>%  
   group_by(region, type) %>% 
-  mutate(n1 = n()) %>% 
+  mutate(n1 = dplyr::n()) %>% 
   ungroup() %>% 
   group_by(biotype, type, region) %>% 
-  mutate(n2 = n(),
+  mutate(n2 = dplyr::n(),
          prop_by_region = (n2 / n1) * 100) %>% 
   arrange(desc(type), desc(region)) %>% 
   ungroup() %>% 
@@ -245,10 +245,10 @@ biotypes_by_sex %>%
   arrange(type, biotype) %>% 
   filter(sex == "male") %>%  
   group_by(region, type) %>% 
-  mutate(n1 = n()) %>% 
+  mutate(n1 = dplyr::n()) %>% 
   ungroup() %>% 
   group_by(biotype, type,region) %>% 
-  mutate(n2 = n(),
+  mutate(n2 = dplyr::n(),
          prop_by_region = (n2 / n1) * 100) %>% 
   arrange(desc(type), desc(region)) %>% 
   ungroup() %>% 

From 22c0b94878c8296964dc95349f1ce6871db67d38 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 24 Oct 2023 13:31:19 -0300
Subject: [PATCH 22/24] fix: modified gitignore

---
 .gitignore                     |  3 +--
 results/tx_enrich/go_terms.csv | 41 +++++++++++++++++-----------------
 2 files changed, 21 insertions(+), 23 deletions(-)

diff --git a/.gitignore b/.gitignore
index 1aaeee8..ee121ee 100644
--- a/.gitignore
+++ b/.gitignore
@@ -20,5 +20,4 @@ renv/*
 slurm*
 run*
 data/*
-results/diff_exp/*
-results/ISA/
+results/*
diff --git a/results/tx_enrich/go_terms.csv b/results/tx_enrich/go_terms.csv
index ddc0a4d..4016f08 100644
--- a/results/tx_enrich/go_terms.csv
+++ b/results/tx_enrich/go_terms.csv
@@ -1,22 +1,21 @@
 ID,Description,GeneRatio,BgRatio,pvalue,p.adjust,qvalue,geneID,Count,group
-GO:0030858,positive regulation of epithelial cell differentiation,3/25,64/18723,8.30298595424994e-5,0.04799125881556465,3.75e-02,PRKCH/NME2/PROM1,3,aINS_female
-GO:0002181,cytoplasmic translation,9/172,148/18723,9.284720354690927e-6,0.022459738537997355,2.17e-02,RPL27/RPL7/RPL24/RPS27/RPL22/EIF3CL/RPL38/EIF3L/RPS3,9,Cg25_male
-GO:0002181,cytoplasmic translation,20/354,148/18723,6.034935546363268e-12,1.8702265258179768e-8,1.78e-08,RPL36A/RPL27/RPS19/RPL39/RPS10/UNK/RPS15A/RPL18/EIF3A/RPL23/RPL10/RPS7/RPS14/RPS23/RPL3/RPS27A/EIF3G/RPL7A/RPL13A/RPL26,20,OFC_female
-GO:0000377,"RNA splicing, via transesterification reactions with bulged adenosine as nucleophile",21/354,320/18723,8.527948419500151e-7,7.696906681208437e-4,7.33e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
-GO:0000398,"mRNA splicing, via spliceosome",21/354,320/18723,8.527948419500151e-7,7.696906681208437e-4,7.33e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
-GO:0000375,"RNA splicing, via transesterification reactions",21/354,324/18723,1.0422977974782387e-6,7.696906681208437e-4,7.33e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
-GO:0022900,electron transport chain,15/354,175/18723,1.2418371541155916e-6,7.696906681208437e-4,7.33e-04,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/GBA/COX7B2/CHCHD2/GSR/PARK7/SDHB/NDUFB10/ADH5/COX6C,15,OFC_female
-GO:0022904,respiratory electron transport chain,12/354,114/18723,1.698069370239057e-6,8.770528297284729e-4,8.35e-04,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/GBA/CHCHD2/PARK7/SDHB/NDUFB10/COX6C,12,OFC_female
-GO:0009060,aerobic respiration,15/354,189/18723,3.252170243494876e-6,0.0014397822263700888,1.37e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/NNT/COX7B2/CHCHD2/PARK7/PDHB/SDHB/NDUFB10/COX6C,15,OFC_female
-GO:0045333,cellular respiration,16/354,230/18723,8.390432950595276e-6,0.0032502439642368448,3.09e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/NNT/GBA/COX7B2/CHCHD2/PARK7/PDHB/SDHB/NDUFB10/COX6C,16,OFC_female
-GO:0008380,RNA splicing,23/354,434/18723,9.56260978898458e-6,0.003292725304007024,3.13e-03,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/CTNNBL1/DDX39B/HNRNPM/FUS/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,23,OFC_female
-GO:0042773,ATP synthesis coupled electron transport,10/354,95/18723,1.2495335857215579e-5,0.003520276892864644,3.35e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/CHCHD2/PARK7/NDUFB10/COX6C,10,OFC_female
-GO:0042775,mitochondrial ATP synthesis coupled electron transport,10/354,95/18723,1.2495335857215579e-5,0.003520276892864644,3.35e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/CHCHD2/PARK7/NDUFB10/COX6C,10,OFC_female
-GO:0006119,oxidative phosphorylation,12/354,141/18723,1.5525975786513112e-5,0.004009583246867011,3.82e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/COX7B2/CHCHD2/PARK7/NDUFB10/COX6C,12,OFC_female
-GO:0022618,ribonucleoprotein complex assembly,15/354,220/18723,2.0326057552656432e-5,0.0048454194119755606,4.61e-03,RPS19/SART1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL13A/SRPK3/YJU2,15,OFC_female
-GO:0022613,ribonucleoprotein complex biogenesis,23/354,463/18723,2.6717121336838507e-5,0.0059140256444901815,5.63e-03,RPL27/RPS19/NOP56/SART1/NOLC1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS7/RPP40/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL7A/C1QBP/RPL13A/RPL26/SRPK3/YJU2,23,OFC_female
-GO:0071826,ribonucleoprotein complex subunit organization,15/354,227/18723,2.9313781484128114e-5,0.006056227254620868,5.76e-03,RPS19/SART1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL13A/SRPK3/YJU2,15,OFC_female
-GO:1903311,regulation of mRNA metabolic process,17/354,288/18723,3.71319720449354e-5,0.0071281511815515786,6.78e-03,SUPT5H/HNRNPA1/LARP1/NCL/SF1/RNPS1/POLR2G/TENT4A/HNRNPM/NBAS/SAFB/FUS/TNRC6B/C1QBP/TBRG4/SRPK3/RBM10,17,OFC_female
-GO:0019646,aerobic electron transport chain,9/354,87/18723,3.910247501980537e-5,0.0071281511815515786,6.78e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/PARK7/NDUFB10/COX6C,9,OFC_female
-GO:2001252,positive regulation of chromosome organization,8/354,82/18723,1.5920489566435716e-4,0.027409776203546822,2.61e-02,HNRNPA2B1/HNRNPA1/DNMT1/SFPQ/SETDB1/GTF2H2/SSBP1/SLX1A,8,OFC_female
-GO:1902253,regulation of intrinsic apoptotic signaling pathway by p53 class mediator,5/354,29/18723,1.9198597909498622e-4,0.031313923642913806,2.98e-02,MARCHF7/ARMC10/UBB/RPS7/RPL26,5,OFC_female
+GO:0002181,cytoplasmic translation,9/173,148/18723,9.729058041215098e-6,0.02356377857582297,2.28e-02,RPL27/RPL7/RPL24/RPS27/RPL22/EIF3CL/RPL38/EIF3L/RPS3,9,Cg25_male
+GO:0002181,cytoplasmic translation,20/356,148/18723,6.686838989923526e-12,2.07492613857327e-8,1.98e-08,RPL36A/RPL27/RPS19/RPL39/RPS10/UNK/RPS15A/RPL18/EIF3A/RPL23/RPL10/RPS7/RPS14/RPS23/RPL3/RPS27A/EIF3G/RPL7A/RPL13A/RPL26,20,OFC_female
+GO:0000377,"RNA splicing, via transesterification reactions with bulged adenosine as nucleophile",21/356,320/18723,9.339644344838082e-7,8.266077207553366e-4,7.88e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
+GO:0000398,"mRNA splicing, via spliceosome",21/356,320/18723,9.339644344838082e-7,8.266077207553366e-4,7.88e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
+GO:0000375,"RNA splicing, via transesterification reactions",21/356,324/18723,1.1410381691315182e-6,8.266077207553366e-4,7.88e-04,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/DDX39B/HNRNPM/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,21,OFC_female
+GO:0022900,electron transport chain,15/356,175/18723,1.3319492761123696e-6,8.266077207553366e-4,7.88e-04,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/GBA/COX7B2/CHCHD2/GSR/PARK7/SDHB/NDUFB10/ADH5/COX6C,15,OFC_female
+GO:0022904,respiratory electron transport chain,12/356,114/18723,1.8004314065485603e-6,9.31123109086697e-4,8.87e-04,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/GBA/CHCHD2/PARK7/SDHB/NDUFB10/COX6C,12,OFC_female
+GO:0009060,aerobic respiration,15/356,189/18723,3.4832897535986416e-6,0.0015440925864880835,1.47e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/NNT/COX7B2/CHCHD2/PARK7/PDHB/SDHB/NDUFB10/COX6C,15,OFC_female
+GO:0045333,cellular respiration,16/356,230/18723,9.002683148259004e-6,0.003491915726130961,3.33e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/NNT/GBA/COX7B2/CHCHD2/PARK7/PDHB/SDHB/NDUFB10/COX6C,16,OFC_female
+GO:0008380,RNA splicing,23/356,434/18723,1.0475791849120676e-5,0.003611820234202384,3.44e-03,HNRNPA2B1/HNRNPA1/HNRNPH3/CASC3/SFPQ/NCL/SART1/DDX46/SF1/RNPS1/HNRNPA3/RBM17/CTNNBL1/DDX39B/HNRNPM/FUS/SRSF5/C1QBP/PNN/ZCRB1/SRPK3/YJU2/RBM10,23,OFC_female
+GO:0042773,ATP synthesis coupled electron transport,10/356,95/18723,1.311973119745828e-5,0.003700956900519367,3.53e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/CHCHD2/PARK7/NDUFB10/COX6C,10,OFC_female
+GO:0042775,mitochondrial ATP synthesis coupled electron transport,10/356,95/18723,1.311973119745828e-5,0.003700956900519367,3.53e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/CHCHD2/PARK7/NDUFB10/COX6C,10,OFC_female
+GO:0006119,oxidative phosphorylation,12/356,141/18723,1.6418404463433016e-5,0.004245525754169387,4.05e-03,COX3/UQCRQ/UQCR11/SDHD/ANTKMT/NDUFB2/COX7C/COX7B2/CHCHD2/PARK7/NDUFB10/COX6C,12,OFC_female
+GO:0022618,ribonucleoprotein complex assembly,15/356,220/18723,2.1703603179094842e-5,0.005180483128056254,4.94e-03,RPS19/SART1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL13A/SRPK3/YJU2,15,OFC_female
+GO:0022613,ribonucleoprotein complex biogenesis,23/356,463/18723,2.9182024528050987e-5,0.006467987293610158,6.16e-03,RPL27/RPS19/NOP56/SART1/NOLC1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS7/RPP40/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL7A/C1QBP/RPL13A/RPL26/SRPK3/YJU2,23,OFC_female
+GO:0071826,ribonucleoprotein complex subunit organization,15/356,227/18723,3.127877009566171e-5,0.006470534907122553,6.17e-03,RPS19/SART1/SF1/DHX30/EIF3A/RPL10/DDX39B/RPS14/RPL3/AGO4/EIF3G/SRSF5/RPL13A/SRPK3/YJU2,15,OFC_female
+GO:1903311,regulation of mRNA metabolic process,17/356,288/18723,3.984445672827929e-5,0.007456575510489551,7.11e-03,SUPT5H/HNRNPA1/LARP1/NCL/SF1/RNPS1/POLR2G/TENT4A/HNRNPM/NBAS/SAFB/FUS/TNRC6B/C1QBP/TBRG4/SRPK3/RBM10,17,OFC_female
+GO:0019646,aerobic electron transport chain,9/356,87/18723,4.085136438231465e-5,0.007456575510489551,7.11e-03,COX3/UQCRQ/UQCR11/SDHD/NDUFB2/COX7C/PARK7/NDUFB10/COX6C,9,OFC_female
+GO:2001252,positive regulation of chromosome organization,8/356,82/18723,1.6545126184103776e-4,0.02852195919404112,2.72e-02,HNRNPA2B1/HNRNPA1/DNMT1/SFPQ/SETDB1/GTF2H2/SSBP1/SLX1A,8,OFC_female
+GO:1902253,regulation of intrinsic apoptotic signaling pathway by p53 class mediator,5/356,29/18723,1.9707873358949942e-4,0.03218606896464299,3.07e-02,MARCHF7/ARMC10/UBB/RPS7/RPL26,5,OFC_female

From 3476857a004556e51b6341aae40b726b122b7671 Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Tue, 24 Oct 2023 13:40:06 -0300
Subject: [PATCH 23/24] fix: rebuilt ppi network after stageR correction

---
 results/networks/model_edges.txt | 5031 ++++++++++++++++--------------
 results/networks/model_nodes.txt | 1172 +++----
 2 files changed, 3265 insertions(+), 2938 deletions(-)

diff --git a/results/networks/model_edges.txt b/results/networks/model_edges.txt
index 493da78..bb85423 100644
--- a/results/networks/model_edges.txt
+++ b/results/networks/model_edges.txt
@@ -1,2408 +1,2709 @@
 node_a	node_b	weight
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\ No newline at end of file
diff --git a/results/networks/model_nodes.txt b/results/networks/model_nodes.txt
index 1c31085..bfebb0e 100644
--- a/results/networks/model_nodes.txt
+++ b/results/networks/model_nodes.txt
@@ -1,574 +1,600 @@
 node_id	alias	shape	size	color	x	y	weight
-0	VAMP3	ELLIPSE	20.0	#ffcccc	509.94	37.11	0.0
-1	VPS53	ELLIPSE	20.0	#ffcccc	426.1	192.06	0.0
-2	PICALM	ELLIPSE	20.0	#ffcccc	230.49	122.35	0.0
-3	STX5	ELLIPSE	20.0	#ffcccc	393.29	22.8	0.0
-4	SNAP47	ELLIPSE	20.0	#ffcccc	614.44	-72.34	0.0
-5	PKP2	ELLIPSE	20.0	#ffcccc	159.97	1087.33	0.0
-6	KRT18	ELLIPSE	20.0	#ffcccc	245.34	1330.12	0.0
-7	CTNNB1	ELLIPSE	20.0	#ffcccc	-50.61	641.73	0.0
-8	MRPS35	ELLIPSE	20.0	#ffcccc	-574.2	88.33	0.0
-9	C18orf32	ELLIPSE	20.0	#ffcccc	-374.66	156.25	0.0
-10	RPL17-C18orf32	ELLIPSE	20.0	#ffcccc	-356.15	151.35	0.0
-11	HSPBP1	ELLIPSE	20.0	#ffcccc	-384.98	32.64	0.0
-12	RPL10	ELLIPSE	20.0	#ffcccc	-434.24	113.75	0.0
-13	RPL3	ELLIPSE	20.0	#ffcccc	-423.12	105.81	0.0
-14	RPS15A	ELLIPSE	20.0	#ffcccc	-482.34	115.58	0.0
-15	RPL13A	ELLIPSE	20.0	#ffcccc	-398.99	137.44	0.0
-16	RPS23	ELLIPSE	20.0	#ffcccc	-447.4	84.53	0.0
-17	RPS14	ELLIPSE	20.0	#ffcccc	-422.63	114.01	0.0
-18	MRPL51	ELLIPSE	20.0	#ffcccc	-823.67	6.22	0.0
-19	RPL23	ELLIPSE	20.0	#ffcccc	-464.6	131.99	0.0
-20	MRPL33	ELLIPSE	20.0	#ffcccc	-536.2	31.95	0.0
-21	MRPS18B	ELLIPSE	20.0	#ffcccc	-755.64	-68.33	0.0
-22	TNS1	ELLIPSE	20.0	#ffcccc	198.61	163.5	0.0
-23	NOLC1	ELLIPSE	20.0	#ffcccc	-113.28	37.12	0.0
-24	ZYX	ELLIPSE	20.0	#ffcccc	102.54	277.44	0.0
-25	VCL	ELLIPSE	20.0	#ffcccc	197.34	409.57	0.0
-26	SLC22A4	ELLIPSE	20.0	#ffcccc	-372.04	1314.96	0.0
-27	PDZK1	ELLIPSE	20.0	#ffcccc	-309.8	1003.47	0.0
-28	PDRG1	ELLIPSE	20.0	#ffcccc	-853.72	-259.75	0.0
-29	PFDN5	ELLIPSE	20.0	#ffcccc	-582.8	61.1	0.0
-30	TENT4A	ELLIPSE	20.0	#ffcccc	377.05	635.17	0.0
-31	RAP1B	ELLIPSE	20.0	#ffcccc	213.46	753.07	0.0
-32	MYL12A	ELLIPSE	20.0	#ffcccc	311.35	551.81	0.0
-33	MANF	ELLIPSE	20.0	#ffcccc	310.85	282.86	0.0
-34	WDR1	ELLIPSE	20.0	#ffcccc	308.6	462.64	0.0
-35	ACTG1	ELLIPSE	20.0	#ffcccc	31.69	513.71	0.0
-36	HSCB	ELLIPSE	20.0	#ffcccc	-1323.18	-47.82	0.0
-37	PMPCA	ELLIPSE	20.0	#ffcccc	-1017.7	-5.2	0.0
-38	SDHB	ELLIPSE	20.0	#ffcccc	-1193.7	2.41	0.0
-39	PNN	ELLIPSE	20.0	#ffcccc	-514.15	-416.36	0.0
-40	RSRC2	ELLIPSE	20.0	#ffcccc	-559.77	-767.95	0.0
-41	HNRNPM	ELLIPSE	20.0	#ffcccc	-501.53	-142.98	0.0
-42	HNRNPA2B1	ELLIPSE	20.0	#ffcccc	-497.34	-31.06	0.0
-43	HNRNPH3	ELLIPSE	20.0	#ffcccc	-509.73	-237.95	0.0
-44	ARGLU1	ELLIPSE	20.0	#ffcccc	-440.35	-528.75	0.0
-45	CASC3	ELLIPSE	20.0	#ffcccc	-575.95	-364.05	0.0
-46	RNPS1	ELLIPSE	20.0	#ffcccc	-479.22	-215.29	0.0
-47	ACOT8	ELLIPSE	20.0	#ffcccc	-1113.99	-338.3	0.0
-48	PEX7	ELLIPSE	20.0	#ffcccc	-571.71	-3.56	0.0
-49	PAOX	ELLIPSE	20.0	#ffcccc	-1332.14	-483.08	0.0
-50	GNPAT	ELLIPSE	20.0	#ffcccc	-1298.08	-372.22	0.0
-51	STAG2	ELLIPSE	20.0	#ffcccc	-69.8	282.64	0.0
-52	JUND	ELLIPSE	20.0	#ffcccc	139.51	337.95	0.0
-53	HIST1H2AC	ELLIPSE	20.0	#ffcccc	-450.77	410.11	0.0
-54	ESR1	ELLIPSE	20.0	#ffcccc	-250.49	409.03	0.0
-55	TERF2	ELLIPSE	20.0	#ffcccc	69.31	84.0	0.0
-56	CCNB1	ELLIPSE	20.0	#ffcccc	-101.73	114.82	0.0
-57	SMC1A	ELLIPSE	20.0	#ffcccc	-39.57	213.34	0.0
-58	CORO1A	ELLIPSE	20.0	#ffcccc	576.31	339.4	0.0
-59	CD37	ELLIPSE	20.0	#ffcccc	826.98	303.89	0.0
-60	POC1A	ELLIPSE	20.0	#ffcccc	304.83	106.23	0.0
-61	DOCK2	ELLIPSE	20.0	#ffcccc	765.82	541.39	0.0
-62	ACTR3	ELLIPSE	20.0	#ffcccc	153.72	439.95	0.0
-63	MGA	ELLIPSE	20.0	#ffcccc	-805.98	752.7	0.0
-64	BOLA2-SMG1P6	ELLIPSE	20.0	#ffcccc	-632.98	819.41	0.0
-65	CBX3	ELLIPSE	20.0	#ffcccc	-630.48	392.63	0.0
-66	GSR	ELLIPSE	20.0	#ffcccc	-1507.04	233.54	0.0
-67	PDHB	ELLIPSE	20.0	#ffcccc	-1010.36	183.82	0.0
-68	GSTP1	ELLIPSE	20.0	#ffcccc	-1814.53	254.78	0.0
-69	TLE5	ELLIPSE	20.0	#ffcccc	197.9	863.38	0.0
-70	SNAPC2	ELLIPSE	20.0	#ffcccc	-750.74	632.84	0.0
-71	GTF2E2	ELLIPSE	20.0	#ffcccc	-770.68	351.95	0.0
-72	POLR2G	ELLIPSE	20.0	#ffcccc	-604.01	243.7	0.0
-73	POLR3G	ELLIPSE	20.0	#ffcccc	-551.14	931.8	0.0
-74	RABAC1	ELLIPSE	20.0	#ffcccc	348.67	1315.69	0.0
-75	NTAQ1	ELLIPSE	20.0	#ffcccc	457.58	1541.3	0.0
-76	RAB5A	ELLIPSE	20.0	#ffcccc	156.37	951.26	0.0
-77	CHN2	ELLIPSE	20.0	#ffcccc	-1305.43	-649.3	0.0
-78	KMT5B	ELLIPSE	20.0	#ffcccc	-1145.65	-467.04	0.0
-79	FIS1	ELLIPSE	20.0	#ffcccc	-1492.47	559.55	0.0
-80	MAF1	ELLIPSE	20.0	#ffcccc	-1219.87	511.76	0.0
-81	SEC61B	ELLIPSE	20.0	#ffcccc	-261.69	142.38	0.0
-82	RPS10-NUDT3	ELLIPSE	20.0	#ffcccc	-424.02	215.48	0.0
-83	RPS7	ELLIPSE	20.0	#ffcccc	-377.69	118.45	0.0
-84	RACK1	ELLIPSE	20.0	#ffcccc	-353.77	196.08	0.0
-85	RPL7	ELLIPSE	20.0	#ffcccc	-375.1	89.32	0.0
-86	RPS10	ELLIPSE	20.0	#ffcccc	-459.13	61.65	0.0
-87	RPS27A	ELLIPSE	20.0	#ffcccc	-321.64	305.85	0.0
-88	CANX	ELLIPSE	20.0	#ffcccc	-247.66	349.25	0.0
-89	RPS19	ELLIPSE	20.0	#ffcccc	-333.85	131.23	0.0
-90	RPL18	ELLIPSE	20.0	#ffcccc	-377.83	198.52	0.0
-91	RPL24	ELLIPSE	20.0	#ffcccc	-486.16	160.42	0.0
-92	RPS27	ELLIPSE	20.0	#ffcccc	-441.76	146.67	0.0
-93	RPL38	ELLIPSE	20.0	#ffcccc	-455.56	183.86	0.0
-94	RPL22	ELLIPSE	20.0	#ffcccc	-389.12	215.99	0.0
-95	RPL7A	ELLIPSE	20.0	#ffcccc	-431.34	47.63	0.0
-96	RPL36A	ELLIPSE	20.0	#ffcccc	-493.84	179.17	0.0
-97	RPL26	ELLIPSE	20.0	#ffcccc	-503.66	125.42	0.0
-98	RPL39	ELLIPSE	20.0	#ffcccc	-551.56	128.01	0.0
-99	RPL27	ELLIPSE	20.0	#ffcccc	-527.45	106.57	0.0
-100	UBE2J2	ELLIPSE	20.0	#ffcccc	-30.13	267.8	0.0
-101	SFXN3	ELLIPSE	20.0	#ffcccc	-1218.11	-58.67	0.0
-102	UQCRQ	ELLIPSE	20.0	#ffcccc	-853.91	78.17	0.0
-103	NUFIP2	ELLIPSE	20.0	#ffcccc	-594.53	164.76	0.0
-104	C1QBP	ELLIPSE	20.0	#ffcccc	-631.76	-160.99	0.0
-105	HSPA8	ELLIPSE	20.0	#ffcccc	-302.84	172.4	0.0
-106	UBAP2L	ELLIPSE	20.0	#ffcccc	-804.28	153.92	0.0
-107	GRSF1	ELLIPSE	20.0	#ffcccc	-941.54	-297.07	0.0
-108	MAGED2	ELLIPSE	20.0	#ffcccc	-303.2	-616.17	0.0
-109	NOP56	ELLIPSE	20.0	#ffcccc	-333.69	22.22	0.0
-110	SSBP1	ELLIPSE	20.0	#ffcccc	-642.76	-85.54	0.0
-111	NME2	ELLIPSE	20.0	#ffcccc	-448.9	-18.74	0.0
-112	GP1BB	ELLIPSE	20.0	#ffcccc	-802.67	-532.91	0.0
-113	TOMM40	ELLIPSE	20.0	#ffcccc	-771.97	-165.62	0.0
-114	DDX39B	ELLIPSE	20.0	#ffcccc	-455.53	-100.09	0.0
-115	CHCHD2	ELLIPSE	20.0	#ffcccc	-1008.83	-84.1	0.0
-116	SNU13	ELLIPSE	20.0	#ffcccc	-423.64	4.53	0.0
-117	PHB1	ELLIPSE	20.0	#ffcccc	-689.94	35.61	0.0
-118	TMEM97	ELLIPSE	20.0	#ffcccc	-100.93	-626.81	0.0
-119	GUK1	ELLIPSE	20.0	#ffcccc	-163.69	-492.3	0.0
-120	JADE1	ELLIPSE	20.0	#ffcccc	-1084.1	-112.03	0.0
-121	YJU2	ELLIPSE	20.0	#ffcccc	-837.04	-402.14	0.0
-122	ING4	ELLIPSE	20.0	#ffcccc	-995.51	325.08	0.0
-123	ZPR1	ELLIPSE	20.0	#ffcccc	-9.26	134.15	0.0
-124	WDR3	ELLIPSE	20.0	#ffcccc	-240.35	16.59	0.0
-125	UBE4B	ELLIPSE	20.0	#ffcccc	177.83	268.94	0.0
-126	UFC1	ELLIPSE	20.0	#ffcccc	44.67	299.09	0.0
-127	IL10RA	ELLIPSE	20.0	#ffcccc	754.55	764.59	0.0
-128	ITGAL	ELLIPSE	20.0	#ffcccc	517.5	834.15	0.0
-129	GLI1	ELLIPSE	20.0	#ffcccc	-326.13	682.9	0.0
-130	SEM1	ELLIPSE	20.0	#ffcccc	-234.68	598.31	0.0
-131	PSMB5	ELLIPSE	20.0	#ffcccc	-308.58	549.26	0.0
-132	PSMB10	ELLIPSE	20.0	#ffcccc	-263.6	535.75	0.0
-133	UBB	ELLIPSE	20.0	#ffcccc	-308.94	360.94	0.0
-134	PTCH2	ELLIPSE	20.0	#ffcccc	-403.19	1066.49	0.0
-135	SUFU	ELLIPSE	20.0	#ffcccc	-351.24	574.7	0.0
-136	ITFG2	ELLIPSE	20.0	#ffcccc	-1357.53	713.25	0.0
-137	BTN2A1	ELLIPSE	20.0	#ffcccc	-1554.82	819.72	0.0
-138	WDR24	ELLIPSE	20.0	#ffcccc	-1270.09	735.0	0.0
-139	ATP6V0B	ELLIPSE	20.0	#ffcccc	-1166.07	613.91	0.0
-140	ATP6V1H	ELLIPSE	20.0	#ffcccc	-1078.9	610.79	0.0
-141	BMT2	ELLIPSE	20.0	#ffcccc	-1287.82	696.35	0.0
-142	RHEB	ELLIPSE	20.0	#ffcccc	-1313.32	633.36	0.0
-143	LAMTOR4	ELLIPSE	20.0	#ffcccc	-1245.99	594.86	0.0
-144	NDUFB10	ELLIPSE	20.0	#ffcccc	-979.88	61.27	0.0
-145	GPLD1	ELLIPSE	20.0	#ffcccc	1667.31	110.5	0.0
-146	PIGW	ELLIPSE	20.0	#ffcccc	1771.44	106.85	0.0
-147	EIF1B	ELLIPSE	20.0	#ffcccc	-461.54	204.48	0.0
-148	EIF3L	ELLIPSE	20.0	#ffcccc	-326.62	38.81	0.0
-149	EIF1	ELLIPSE	20.0	#ffcccc	-425.81	171.06	0.0
-150	RPS3	ELLIPSE	20.0	#ffcccc	-402.31	77.49	0.0
-151	EIF3CL	ELLIPSE	20.0	#ffcccc	-321.2	75.75	0.0
-152	EIF3C	ELLIPSE	20.0	#ffcccc	-321.93	109.18	0.0
-153	EIF3A	ELLIPSE	20.0	#ffcccc	-326.9	166.65	0.0
-154	EIF3G	ELLIPSE	20.0	#ffcccc	-394.5	77.46	0.0
-155	TTC31	ELLIPSE	20.0	#ffcccc	-334.42	-398.69	0.0
-156	TCEANC2	ELLIPSE	20.0	#ffcccc	-883.1	513.21	0.0
-157	SUPT5H	ELLIPSE	20.0	#ffcccc	-696.58	607.17	0.0
-158	TBPL1	ELLIPSE	20.0	#ffcccc	-913.67	370.93	0.0
-159	KPNA3	ELLIPSE	20.0	#ffcccc	-1071.76	378.91	0.0
-160	TADA2B	ELLIPSE	20.0	#ffcccc	-620.98	300.36	0.0
-161	YEATS2	ELLIPSE	20.0	#ffcccc	-690.31	346.4	0.0
-162	FGF23	ELLIPSE	20.0	#ffcccc	-178.94	646.11	0.0
-163	MET	ELLIPSE	20.0	#ffcccc	-24.55	788.5	0.0
-164	KDR	ELLIPSE	20.0	#ffcccc	-223.35	819.77	0.0
-165	FGFR1	ELLIPSE	20.0	#ffcccc	-180.7	738.99	0.0
-166	SLC35B1	ELLIPSE	20.0	#ffcccc	630.9	243.92	0.0
-167	TFG	ELLIPSE	20.0	#ffcccc	601.53	-147.67	0.0
-168	GRIA1	ELLIPSE	20.0	#ffcccc	514.81	-58.83	0.0
-169	ACVR2A	ELLIPSE	20.0	#ffcccc	104.26	1479.42	0.0
-170	MAGI2	ELLIPSE	20.0	#ffcccc	93.52	1238.44	0.0
-171	TWIST1	ELLIPSE	20.0	#ffcccc	-95.22	788.59	0.0
-172	FOXO3	ELLIPSE	20.0	#ffcccc	-158.06	865.26	0.0
-173	PLA2G12A	ELLIPSE	20.0	#ffcccc	971.22	792.9	0.0
-174	PEDS1-UBE2V1	ELLIPSE	20.0	#ffcccc	743.95	698.69	0.0
-175	PLD4	ELLIPSE	20.0	#ffcccc	880.22	785.73	0.0
-176	PLD3	ELLIPSE	20.0	#ffcccc	938.07	853.85	0.0
-177	LPCAT1	ELLIPSE	20.0	#ffcccc	1047.64	848.59	0.0
-178	SNRPA	ELLIPSE	20.0	#ffcccc	-574.27	-244.76	0.0
-179	MFAP1	ELLIPSE	20.0	#ffcccc	-577.14	-196.35	0.0
-180	HNRNPA3	ELLIPSE	20.0	#ffcccc	-534.15	-100.72	0.0
-181	MBNL2	ELLIPSE	20.0	#ffcccc	-684.44	-622.04	0.0
-182	FMC1-LUC7L2	ELLIPSE	20.0	#ffcccc	-684.51	-486.33	0.0
-183	CTNNBL1	ELLIPSE	20.0	#ffcccc	-445.23	-179.6	0.0
-184	FUBP1	ELLIPSE	20.0	#ffcccc	-555.03	-64.46	0.0
-185	HNRNPA1	ELLIPSE	20.0	#ffcccc	-502.11	1.64	0.0
-186	RBM17	ELLIPSE	20.0	#ffcccc	-486.54	-368.44	0.0
-187	SF1	ELLIPSE	20.0	#ffcccc	-537.95	-217.15	0.0
-188	SFPQ	ELLIPSE	20.0	#ffcccc	-419.46	-124.53	0.0
-189	SART1	ELLIPSE	20.0	#ffcccc	-641.45	-363.58	0.0
-190	SF3B5	ELLIPSE	20.0	#ffcccc	-670.38	-137.05	0.0
-191	SNRPB2	ELLIPSE	20.0	#ffcccc	-618.06	-273.76	0.0
-192	ATP5F1E	ELLIPSE	20.0	#ffcccc	-895.75	229.43	0.0
-193	MT-CO3	ELLIPSE	20.0	#ffcccc	-1099.23	126.5	0.0
-194	PPA2	ELLIPSE	20.0	#ffcccc	-1088.49	531.2	0.0
-195	UQCR11	ELLIPSE	20.0	#ffcccc	-1067.87	183.05	0.0
-196	NDUFB2	ELLIPSE	20.0	#ffcccc	-943.76	124.45	0.0
-197	COX6C	ELLIPSE	20.0	#ffcccc	-1030.7	95.87	0.0
-198	COX7C	ELLIPSE	20.0	#ffcccc	-746.18	121.49	0.0
-199	CLPP	ELLIPSE	20.0	#ffcccc	-1501.41	-67.07	0.0
-200	DNAJC8	ELLIPSE	20.0	#ffcccc	-498.07	-312.41	0.0
-201	HTATSF1	ELLIPSE	20.0	#ffcccc	-768.73	-416.11	0.0
-202	DDX46	ELLIPSE	20.0	#ffcccc	-679.14	-392.08	0.0
-203	RAB40A	ELLIPSE	20.0	#ffcccc	-523.68	618.43	0.0
-204	RAB8B	ELLIPSE	20.0	#ffcccc	87.23	799.16	0.0
-205	CCT3	ELLIPSE	20.0	#ffcccc	-314.18	-25.23	0.0
-206	HLA-DRA	ELLIPSE	20.0	#ffcccc	249.25	406.39	0.0
-207	KCNH2	ELLIPSE	20.0	#ffcccc	-537.66	320.11	0.0
-208	PIN1	ELLIPSE	20.0	#ffcccc	-217.32	562.25	0.0
-209	NCOR2	ELLIPSE	20.0	#ffcccc	-322.34	623.59	0.0
-210	PPP2R5A	ELLIPSE	20.0	#ffcccc	-2.39	585.36	0.0
-211	PRKCD	ELLIPSE	20.0	#ffcccc	-265.33	779.62	0.0
-212	AXIN1	ELLIPSE	20.0	#ffcccc	-124.18	645.8	0.0
-213	IRF3	ELLIPSE	20.0	#ffcccc	-144.55	435.93	0.0
-214	JPT2	ELLIPSE	20.0	#ffcccc	292.0	-366.88	0.0
-215	STMN1	ELLIPSE	20.0	#ffcccc	52.83	-136.77	0.0
-216	MAP2K3	ELLIPSE	20.0	#ffcccc	110.18	610.62	0.0
-217	SIPA1L2	ELLIPSE	20.0	#ffcccc	507.75	1035.82	0.0
-218	BDNF	ELLIPSE	20.0	#ffcccc	-89.66	897.5	0.0
-219	SLX1A	ELLIPSE	20.0	#ffcccc	-739.57	915.35	0.0
-220	ERCC4	ELLIPSE	20.0	#ffcccc	-550.31	553.85	0.0
-221	TUBG2	ELLIPSE	20.0	#ffcccc	1.45	-499.79	0.0
-222	TOPORS	ELLIPSE	20.0	#ffcccc	126.35	-531.26	0.0
-223	BLOC1S2	ELLIPSE	20.0	#ffcccc	18.76	-618.87	0.0
-224	KIFC1	ELLIPSE	20.0	#ffcccc	192.42	-325.97	0.0
-225	NME7	ELLIPSE	20.0	#ffcccc	-246.25	-467.49	0.0
-226	CIAO3	ELLIPSE	20.0	#ffcccc	1823.11	-100.05	0.0
-227	CIAO2A	ELLIPSE	20.0	#ffcccc	1765.2	-180.64	0.0
-228	MLLT6	ELLIPSE	20.0	#ffcccc	479.78	344.95	0.0
-229	ZC3H4	ELLIPSE	20.0	#ffcccc	-391.98	-621.77	0.0
-230	CLP1	ELLIPSE	20.0	#ffcccc	-407.44	-223.42	0.0
-231	DFFA	ELLIPSE	20.0	#ffcccc	-275.99	-345.67	0.0
-232	MYSM1	ELLIPSE	20.0	#ffcccc	-320.65	481.01	0.0
-233	MPND	ELLIPSE	20.0	#ffcccc	-341.39	377.47	0.0
-234	CCT8	ELLIPSE	20.0	#ffcccc	-296.71	48.13	0.0
-235	EIF6	ELLIPSE	20.0	#ffcccc	-458.53	35.41	0.0
-236	EIF4A1	ELLIPSE	20.0	#ffcccc	-375.12	18.21	0.0
-237	FUS	ELLIPSE	20.0	#ffcccc	-551.96	74.89	0.0
-238	LARP1	ELLIPSE	20.0	#ffcccc	-400.03	-41.46	0.0
-239	ARID1A	ELLIPSE	20.0	#ffcccc	-347.87	445.27	0.0
-240	DHX30	ELLIPSE	20.0	#ffcccc	-745.29	-205.83	0.0
-241	HNRNPA1L2	ELLIPSE	20.0	#ffcccc	-623.66	-198.44	0.0
-242	RXRA	ELLIPSE	20.0	#ffcccc	-507.58	566.14	0.0
-243	SAFB	ELLIPSE	20.0	#ffcccc	-427.19	-71.5	0.0
-244	SMARCA4	ELLIPSE	20.0	#ffcccc	-400.24	362.53	0.0
-245	IARS2	ELLIPSE	20.0	#ffcccc	-1141.02	-166.69	0.0
-246	H3-3A	ELLIPSE	20.0	#ffcccc	-735.16	544.72	0.0
-247	FBXL19	ELLIPSE	20.0	#ffcccc	-634.27	600.78	0.0
-248	SUV39H1	ELLIPSE	20.0	#ffcccc	-676.86	560.85	0.0
-249	TONSL	ELLIPSE	20.0	#ffcccc	-957.03	602.71	0.0
-250	SGF29	ELLIPSE	20.0	#ffcccc	-757.03	314.2	0.0
-251	ING1	ELLIPSE	20.0	#ffcccc	-1013.98	836.37	0.0
-252	UBN1	ELLIPSE	20.0	#ffcccc	-1032.93	777.54	0.0
-253	SETDB1	ELLIPSE	20.0	#ffcccc	-836.41	678.34	0.0
-254	H2BC8	ELLIPSE	20.0	#ffcccc	-505.25	453.05	0.0
-255	CARM1	ELLIPSE	20.0	#ffcccc	-492.36	683.14	0.0
-256	H2AC8	ELLIPSE	20.0	#ffcccc	-757.85	407.74	0.0
-257	BRD8	ELLIPSE	20.0	#ffcccc	-673.88	510.15	0.0
-258	TP63	ELLIPSE	20.0	#ffcccc	-458.37	629.39	0.0
-259	DERPC	ELLIPSE	20.0	#ffcccc	376.13	-114.16	0.0
-260	WRAP53	ELLIPSE	20.0	#ffcccc	-10.93	-55.45	0.0
-261	PPP6R3	ELLIPSE	20.0	#ffcccc	243.03	-113.82	0.0
-262	BTG1	ELLIPSE	20.0	#ffcccc	-65.56	1185.9	0.0
-263	CCNJ	ELLIPSE	20.0	#ffcccc	104.07	-20.34	0.0
-264	DNMT1	ELLIPSE	20.0	#ffcccc	-511.48	406.84	0.0
-265	PRKDC	ELLIPSE	20.0	#ffcccc	-317.8	281.59	0.0
-266	CNPPD1	ELLIPSE	20.0	#ffcccc	142.95	67.76	0.0
-267	STIL	ELLIPSE	20.0	#ffcccc	103.96	-95.77	0.0
-268	CDK17	ELLIPSE	20.0	#ffcccc	155.37	1.04	0.0
-269	UBE2E1	ELLIPSE	20.0	#ffcccc	-125.97	268.57	0.0
-270	RCC1	ELLIPSE	20.0	#ffcccc	-725.29	277.94	0.0
-271	CENPU	ELLIPSE	20.0	#ffcccc	11.99	-9.35	0.0
-272	SKA3	ELLIPSE	20.0	#ffcccc	166.26	-112.29	0.0
-273	CEP55	ELLIPSE	20.0	#ffcccc	27.84	-209.66	0.0
-274	LIN9	ELLIPSE	20.0	#ffcccc	92.58	30.63	0.0
-275	CCNE1	ELLIPSE	20.0	#ffcccc	-88.23	162.77	0.0
-276	TOP2A	ELLIPSE	20.0	#ffcccc	-20.22	79.7	0.0
-277	ARHGAP9	ELLIPSE	20.0	#ffcccc	986.04	514.46	0.0
-278	CD247	ELLIPSE	20.0	#ffcccc	517.11	550.45	0.0
-279	OASL	ELLIPSE	20.0	#ffcccc	-395.62	268.8	0.0
-280	IFITM1	ELLIPSE	20.0	#ffcccc	-141.52	552.5	0.0
-281	LMO2	ELLIPSE	20.0	#ffcccc	-327.4	-206.84	0.0
-282	MAPRE2	ELLIPSE	20.0	#ffcccc	-97.57	-182.51	0.0
-283	HTRA2	ELLIPSE	20.0	#ffcccc	464.37	641.46	0.0
-284	TRAF3	ELLIPSE	20.0	#ffcccc	176.98	517.41	0.0
-285	COG3	ELLIPSE	20.0	#ffcccc	713.09	65.31	0.0
-286	COPZ1	ELLIPSE	20.0	#ffcccc	1046.86	25.22	0.0
-287	TBRG4	ELLIPSE	20.0	#ffcccc	-996.07	-488.98	0.0
-288	MARCHF7	ELLIPSE	20.0	#ffcccc	-685.86	-788.31	0.0
-289	PCNP	ELLIPSE	20.0	#ffcccc	-608.31	-461.39	0.0
-290	BLK	ELLIPSE	20.0	#ffcccc	-235.97	1046.38	0.0
-291	EFNA5	ELLIPSE	20.0	#ffcccc	-152.69	952.11	0.0
-292	RASA1	ELLIPSE	20.0	#ffcccc	-262.76	872.48	0.0
-293	DERL1	ELLIPSE	20.0	#ffcccc	-112.47	330.97	0.0
-294	UBXN1	ELLIPSE	20.0	#ffcccc	-91.52	216.89	0.0
-295	RNF139	ELLIPSE	20.0	#ffcccc	-114.52	471.47	0.0
-296	NGLY1	ELLIPSE	20.0	#ffcccc	21.66	360.87	0.0
-297	HINT2	ELLIPSE	20.0	#ffcccc	-961.49	0.01	0.0
-298	RIPK1	ELLIPSE	20.0	#ffcccc	-24.0	467.83	0.0
-299	MAP4K2	ELLIPSE	20.0	#ffcccc	267.76	654.0	0.0
-300	UBE2V1	ELLIPSE	20.0	#ffcccc	-45.92	395.21	0.0
-301	IKBKG	ELLIPSE	20.0	#ffcccc	-46.96	532.37	0.0
-302	CHRNA1	ELLIPSE	20.0	#ffcccc	221.97	-992.49	0.0
-303	CHRM1	ELLIPSE	20.0	#ffcccc	278.94	-837.28	0.0
-304	CACNG8	ELLIPSE	20.0	#ffcccc	618.52	91.9	0.0
-305	WNT8A	ELLIPSE	20.0	#ffcccc	-3.36	866.61	0.0
-306	DVL1	ELLIPSE	20.0	#ffcccc	-131.39	750.81	0.0
-307	PPP4R4	ELLIPSE	20.0	#ffcccc	347.78	935.66	0.0
-308	USP22	ELLIPSE	20.0	#ffcccc	-565.76	386.87	0.0
-309	SAP130	ELLIPSE	20.0	#ffcccc	-684.38	433.4	0.0
-310	KCNAB1	ELLIPSE	20.0	#ffcccc	-813.1	291.93	0.0
-311	KCNQ4	ELLIPSE	20.0	#ffcccc	-553.32	212.79	0.0
-312	SCPEP1	ELLIPSE	20.0	#ffcccc	-1390.49	591.36	0.0
-313	GAPVD1	ELLIPSE	20.0	#ffcccc	32.38	967.04	0.0
-314	FBXO6	ELLIPSE	20.0	#ffcccc	-93.85	-92.97	0.0
-315	GBA1	ELLIPSE	20.0	#ffcccc	-76.33	-44.98	0.0
-316	FKBP9	ELLIPSE	20.0	#ffcccc	-148.39	-57.82	0.0
-317	PCBP4	ELLIPSE	20.0	#ffcccc	109.04	726.43	0.0
-318	DNAJC5G	ELLIPSE	20.0	#ffcccc	-1010.42	-677.28	0.0
-319	ITGAE	ELLIPSE	20.0	#ffcccc	321.91	819.09	0.0
-320	ITGA9	ELLIPSE	20.0	#ffcccc	426.91	791.68	0.0
-321	MED15	ELLIPSE	20.0	#ffcccc	-795.46	573.36	0.0
-322	ANGPTL4	ELLIPSE	20.0	#ffcccc	-667.9	760.63	0.0
-323	UNK	ELLIPSE	20.0	#ffcccc	-213.97	438.57	0.0
-324	ANP32B	ELLIPSE	20.0	#ffcccc	65.16	144.32	0.0
-325	MYO9B	ELLIPSE	20.0	#ffcccc	463.84	489.29	0.0
-326	AP2S1	ELLIPSE	20.0	#ffcccc	212.42	211.34	0.0
-327	BAIAP2L2	ELLIPSE	20.0	#ffcccc	436.56	98.02	0.0
-328	SGIP1	ELLIPSE	20.0	#ffcccc	476.04	158.37	0.0
-329	AP1B1	ELLIPSE	20.0	#ffcccc	141.22	195.23	0.0
-330	AP2A1	ELLIPSE	20.0	#ffcccc	265.41	177.42	0.0
-331	WDR76	ELLIPSE	20.0	#ffcccc	-182.39	-426.84	0.0
-332	GABARAP	ELLIPSE	20.0	#ffcccc	-678.67	951.22	0.0
-333	PLCB4	ELLIPSE	20.0	#ffcccc	-145.62	1002.2	0.0
-334	KIF1B	ELLIPSE	20.0	#ffcccc	366.26	-538.17	0.0
-335	KIF3C	ELLIPSE	20.0	#ffcccc	450.41	-561.15	0.0
-336	KIF5A	ELLIPSE	20.0	#ffcccc	482.89	-487.05	0.0
-337	KLC2	ELLIPSE	20.0	#ffcccc	402.0	-471.99	0.0
-338	IFT46	ELLIPSE	20.0	#ffcccc	432.98	-648.89	0.0
-339	CPSF7	ELLIPSE	20.0	#ffcccc	-641.81	-308.07	0.0
-340	SRSF5	ELLIPSE	20.0	#ffcccc	-462.99	-271.19	0.0
-341	GAS8	ELLIPSE	20.0	#ffcccc	-862.58	1092.79	0.0
-342	FLNC	ELLIPSE	20.0	#ffcccc	635.36	956.01	0.0
-343	SRP9	ELLIPSE	20.0	#ffcccc	-497.63	58.11	0.0
-344	ALDH8A1	ELLIPSE	20.0	#ffcccc	-624.41	1526.4	0.0
-345	ANG	ELLIPSE	20.0	#ffcccc	-588.52	1307.57	0.0
-346	ZCRB1	ELLIPSE	20.0	#ffcccc	-735.09	5.72	0.0
-347	SNRNP25	ELLIPSE	20.0	#ffcccc	-850.48	-39.65	0.0
-348	TMEM19	ELLIPSE	20.0	#ffcccc	1683.35	-376.41	0.0
-349	BSCL2	ELLIPSE	20.0	#ffcccc	1625.83	-294.62	0.0
-350	UBE2Q2	ELLIPSE	20.0	#ffcccc	-98.33	405.89	0.0
-351	UBE2G1	ELLIPSE	20.0	#ffcccc	-124.51	367.9	0.0
-352	UBE2F	ELLIPSE	20.0	#ffcccc	35.74	411.93	0.0
-353	UBE2E2	ELLIPSE	20.0	#ffcccc	-72.63	344.11	0.0
-354	UBE2A	ELLIPSE	20.0	#ffcccc	-189.86	300.05	0.0
-355	SEPTIN12	ELLIPSE	20.0	#ffcccc	1634.7	-459.12	0.0
-356	TMEM250	ELLIPSE	20.0	#ffcccc	1708.11	-533.87	0.0
-357	SEPTIN9	ELLIPSE	20.0	#ffcccc	1607.92	-560.85	0.0
-358	CISD2	ELLIPSE	20.0	#ffcccc	-1347.82	59.48	0.0
-359	SLC25A45	ELLIPSE	20.0	#ffcccc	-1242.96	-146.51	0.0
-360	PARK7	ELLIPSE	20.0	#ffcccc	-455.75	266.77	0.0
-361	APOBEC3G	ELLIPSE	20.0	#ffcccc	-944.2	209.06	0.0
-362	CHCHD6	ELLIPSE	20.0	#ffcccc	-1086.52	-176.09	0.0
-363	SDHD	ELLIPSE	20.0	#ffcccc	-1245.94	39.37	0.0
-364	TIMMDC1	ELLIPSE	20.0	#ffcccc	-1196.41	99.17	0.0
-365	CFAP45	ELLIPSE	20.0	#ffcccc	-1099.31	1204.49	0.0
-366	CBX8	ELLIPSE	20.0	#ffcccc	-847.75	402.77	0.0
-367	H1-10	ELLIPSE	20.0	#ffcccc	-1023.88	495.96	0.0
-368	JARID2	ELLIPSE	20.0	#ffcccc	-835.44	545.24	0.0
-369	CASP8AP2	ELLIPSE	20.0	#ffcccc	-1123.51	470.87	0.0
-370	CETN2	ELLIPSE	20.0	#ffcccc	-616.65	494.07	0.0
-371	PHC1	ELLIPSE	20.0	#ffcccc	-914.62	442.65	0.0
-372	CCDC97	ELLIPSE	20.0	#ffcccc	-920.98	-428.42	0.0
-373	SCYL1	ELLIPSE	20.0	#ffcccc	1215.19	50.32	0.0
-374	CACNA1G	ELLIPSE	20.0	#ffcccc	983.73	-126.32	0.0
-375	GRID2	ELLIPSE	20.0	#ffcccc	708.94	-82.63	0.0
-376	EPB41L1	ELLIPSE	20.0	#ffcccc	732.98	-29.72	0.0
-377	PRCC	ELLIPSE	20.0	#ffcccc	-675.93	-875.59	0.0
-378	RBM10	ELLIPSE	20.0	#ffcccc	-607.75	-564.74	0.0
-379	FANCF	ELLIPSE	20.0	#ffcccc	-409.86	555.53	0.0
-380	EGLN1	ELLIPSE	20.0	#ffcccc	-741.05	477.79	0.0
-381	CHMP7	ELLIPSE	20.0	#ffcccc	-428.27	503.25	0.0
-382	CHMP6	ELLIPSE	20.0	#ffcccc	-475.72	504.99	0.0
-383	GTF2H2	ELLIPSE	20.0	#ffcccc	-566.3	441.83	0.0
-384	COMMD6	ELLIPSE	20.0	#ffcccc	-557.27	694.0	0.0
-385	TRIM32	ELLIPSE	20.0	#ffcccc	-160.83	391.57	0.0
-386	BUB3	ELLIPSE	20.0	#ffcccc	-256.76	-31.66	0.0
-387	GPS1	ELLIPSE	20.0	#ffcccc	-454.27	448.88	0.0
-388	ELOC	ELLIPSE	20.0	#ffcccc	-623.69	455.52	0.0
-389	RPP40	ELLIPSE	20.0	#ffcccc	-287.62	84.19	0.0
-390	SPRED3	ELLIPSE	20.0	#ffcccc	-278.07	649.87	0.0
-391	KLHL12	ELLIPSE	20.0	#ffcccc	-358.7	787.16	0.0
-392	LGR6	ELLIPSE	20.0	#ffcccc	-165.59	505.39	0.0
-393	XRCC3	ELLIPSE	20.0	#ffcccc	-11.23	328.31	0.0
-394	JOSD2	ELLIPSE	20.0	#ffcccc	-217.58	500.87	0.0
-395	ANXA6	ELLIPSE	20.0	#ffcccc	-299.94	1199.91	0.0
-396	GPR174	ELLIPSE	20.0	#ffcccc	662.33	731.19	0.0
-397	INPPL1	ELLIPSE	20.0	#ffcccc	410.76	863.49	0.0
-398	P2RX7	ELLIPSE	20.0	#ffcccc	826.89	891.08	0.0
-399	CD40LG	ELLIPSE	20.0	#ffcccc	540.77	649.33	0.0
-400	GRAP2	ELLIPSE	20.0	#ffcccc	571.77	491.77	0.0
-401	GNRH1	ELLIPSE	20.0	#ffcccc	380.45	-1094.33	0.0
-402	CCK	ELLIPSE	20.0	#ffcccc	396.41	-942.94	0.0
-403	EDN3	ELLIPSE	20.0	#ffcccc	314.25	-1004.38	0.0
-404	LIN7C	ELLIPSE	20.0	#ffcccc	758.0	-984.35	0.0
-405	SYN1	ELLIPSE	20.0	#ffcccc	651.68	-911.09	0.0
-406	HSD17B12	ELLIPSE	20.0	#ffcccc	-990.53	-239.08	0.0
-407	DNAJC1	ELLIPSE	20.0	#ffcccc	-232.15	96.99	0.0
-408	GSPT2	ELLIPSE	20.0	#ffcccc	-317.04	-83.0	0.0
-409	TM7SF2	ELLIPSE	20.0	#ffcccc	1357.53	-2853.57	0.0
-410	DHCR24	ELLIPSE	20.0	#ffcccc	1386.83	-2751.1	0.0
-411	ITM2B	ELLIPSE	20.0	#ffcccc	383.53	402.63	0.0
-412	DONSON	ELLIPSE	20.0	#ffcccc	153.89	-165.18	0.0
-413	NBAS	ELLIPSE	20.0	#ffcccc	1209.84	-29.9	0.0
-414	SETBP1	ELLIPSE	20.0	#ffcccc	-848.41	944.83	0.0
-415	ADAMTS18	ELLIPSE	20.0	#ffcccc	1471.0	249.48	0.0
-416	ADAMTS3	ELLIPSE	20.0	#ffcccc	1573.78	235.98	0.0
-417	ADAMTSL2	ELLIPSE	20.0	#ffcccc	1534.97	331.72	0.0
-418	SCN3A	ELLIPSE	20.0	#ffcccc	1134.92	-162.24	0.0
-419	SCN3B	ELLIPSE	20.0	#ffcccc	1163.38	-233.54	0.0
-420	SCN1B	ELLIPSE	20.0	#ffcccc	1084.62	-249.37	0.0
-421	PLA2G4E	ELLIPSE	20.0	#ffcccc	969.96	746.43	0.0
-422	ABCA6	ELLIPSE	20.0	#ffcccc	-178.8	1188.82	0.0
-423	ODF1	ELLIPSE	20.0	#ffcccc	-113.55	-398.3	0.0
-424	BRIX1	ELLIPSE	20.0	#ffcccc	-370.56	-1.0	0.0
-425	TSC22D1	ELLIPSE	20.0	#ffcccc	527.88	1685.35	0.0
-426	SLC6A1	ELLIPSE	20.0	#ffcccc	559.13	-879.37	0.0
-427	CPNE6	ELLIPSE	20.0	#ffcccc	446.34	-850.97	0.0
-428	SNCB	ELLIPSE	20.0	#ffcccc	489.26	-777.33	0.0
-429	LY6H	ELLIPSE	20.0	#ffcccc	514.8	-950.19	0.0
-430	SYNPR	ELLIPSE	20.0	#ffcccc	463.28	-906.72	0.0
-431	GPC2	ELLIPSE	20.0	#ffcccc	1439.41	-455.41	0.0
-432	HS3ST4	ELLIPSE	20.0	#ffcccc	1538.41	-425.22	0.0
-433	TAMALIN	ELLIPSE	20.0	#ffcccc	-54.73	-3002.12	0.0
-434	MARCHF2	ELLIPSE	20.0	#ffcccc	-111.81	-2915.62	0.0
-435	NCL	ELLIPSE	20.0	#ffcccc	-358.91	-36.72	0.0
-436	UBXN6	ELLIPSE	20.0	#ffcccc	13.3	-283.55	0.0
-437	TRAPPC9	ELLIPSE	20.0	#ffcccc	584.72	-6.18	0.0
-438	DNAI3	ELLIPSE	20.0	#ffcccc	-1386.84	1602.48	0.0
-439	CCDC114	ELLIPSE	20.0	#ffcccc	-1306.88	1286.89	0.0
-440	FABP1	ELLIPSE	20.0	#ffcccc	-500.64	899.08	0.0
-441	RGL1	ELLIPSE	20.0	#ffcccc	-578.92	853.18	0.0
-442	CHD9	ELLIPSE	20.0	#ffcccc	-508.81	745.51	0.0
-443	ADH5	ELLIPSE	20.0	#ffcccc	-1966.95	314.33	0.0
-444	NOL10	ELLIPSE	20.0	#ffcccc	-302.19	6.75	0.0
-445	NKD2	ELLIPSE	20.0	#ffcccc	-75.29	1089.86	0.0
-446	RP9	ELLIPSE	20.0	#ffcccc	-781.89	-698.68	0.0
-447	RPP25L	ELLIPSE	20.0	#ffcccc	-204.84	-97.44	0.0
-448	PRDX3	ELLIPSE	20.0	#ffcccc	-1119.41	-52.8	0.0
-449	CKB	ELLIPSE	20.0	#ffcccc	-766.85	207.79	0.0
-450	ALDOA	ELLIPSE	20.0	#ffcccc	-689.6	201.15	0.0
-451	RNF214	ELLIPSE	20.0	#ffcccc	4920.51	367.34	0.0
-452	SMG8	ELLIPSE	20.0	#ffcccc	4829.13	415.96	0.0
-453	NABP1	ELLIPSE	20.0	#ffcccc	-1047.62	303.07	0.0
-454	TMEM256	ELLIPSE	20.0	#ffcccc	-1356.88	-103.81	0.0
-455	RAB29	ELLIPSE	20.0	#ffcccc	-1464.03	-125.37	0.0
-456	TMEM14C	ELLIPSE	20.0	#ffcccc	-1355.44	-190.38	0.0
-457	TPST1	ELLIPSE	20.0	#ffcccc	690.52	-2926.02	0.0
-458	EIF2B1	ELLIPSE	20.0	#ffcccc	638.2	-3015.99	0.0
-459	OR52A5	ELLIPSE	20.0	#ffcccc	-78.11	-850.71	0.0
-460	GNAL	ELLIPSE	20.0	#ffcccc	4.07	-733.22	0.0
-461	OAZ1	ELLIPSE	20.0	#ffcccc	-237.51	682.85	0.0
-462	SRP72	ELLIPSE	20.0	#ffcccc	-628.06	114.07	0.0
-463	PBDC1	ELLIPSE	20.0	#ffcccc	-791.57	-100.67	0.0
-464	LCMT2	ELLIPSE	20.0	#ffcccc	522.83	1137.87	0.0
-465	LPAR4	ELLIPSE	20.0	#ffcccc	163.54	-830.83	0.0
-466	GMPPA	ELLIPSE	20.0	#ffcccc	-805.0	1347.64	0.0
-467	FNIP1	ELLIPSE	20.0	#ffcccc	-1108.72	794.41	0.0
-468	TBC1D25	ELLIPSE	20.0	#ffcccc	-848.8	1197.4	0.0
-469	ATG5	ELLIPSE	20.0	#ffcccc	-767.97	1222.51	0.0
-470	VSNL1	ELLIPSE	20.0	#ffcccc	587.36	-731.89	0.0
-471	CEND1	ELLIPSE	20.0	#ffcccc	603.51	-807.59	0.0
-472	TYW1B	ELLIPSE	20.0	#ffcccc	-26.75	-346.42	0.0
-473	FTSJ1	ELLIPSE	20.0	#ffcccc	-270.75	-173.16	0.0
-474	PUS7L	ELLIPSE	20.0	#ffcccc	-229.25	-159.5	0.0
-475	DPH5	ELLIPSE	20.0	#ffcccc	-156.79	7.54	0.0
-476	ELP2	ELLIPSE	20.0	#ffcccc	-126.85	-233.48	0.0
-477	DDX24	ELLIPSE	20.0	#ffcccc	-254.28	-74.11	0.0
-478	B4GAT1	ELLIPSE	20.0	#ffcccc	1513.79	-252.17	0.0
-479	PRELP	ELLIPSE	20.0	#ffcccc	1590.31	-175.91	0.0
-480	LARGE2	ELLIPSE	20.0	#ffcccc	1438.77	-326.64	0.0
-481	RHNO1	ELLIPSE	20.0	#ffcccc	-786.47	870.73	0.0
-482	RPH3A	ELLIPSE	20.0	#ffcccc	255.57	1075.48	0.0
-483	KCTD2	ELLIPSE	20.0	#ffcccc	-482.67	1119.02	0.0
-484	KLHL2	ELLIPSE	20.0	#ffcccc	-518.68	999.36	0.0
-485	ATAD5	ELLIPSE	20.0	#ffcccc	228.92	271.1	0.0
-486	DLGAP1	ELLIPSE	20.0	#ffcccc	175.04	1464.42	0.0
-487	RAB4B	ELLIPSE	20.0	#ffcccc	91.28	1088.8	0.0
-488	CFAP299	ELLIPSE	20.0	#ffcccc	-1140.87	1366.33	0.0
-489	ECT2L	ELLIPSE	20.0	#ffcccc	427.32	-292.97	0.0
-490	B3GNT4	ELLIPSE	20.0	#ffcccc	1665.18	-101.31	0.0
-491	KDM3A	ELLIPSE	20.0	#ffcccc	-278.4	588.33	0.0
-492	GTF3A	ELLIPSE	20.0	#ffcccc	-386.22	626.23	0.0
-493	PELI3	ELLIPSE	20.0	#ffcccc	162.29	584.42	0.0
-494	OR10K2	ELLIPSE	20.0	#ffcccc	83.59	-864.42	0.0
-495	PHF21B	ELLIPSE	20.0	#ffcccc	-552.84	779.12	0.0
-496	RTN4IP1	ELLIPSE	20.0	#ffcccc	458.29	258.23	0.0
-497	SRPK3	ELLIPSE	20.0	#ffcccc	-502.31	-479.67	0.0
-498	PRKCH	ELLIPSE	20.0	#ffcccc	-291.94	1519.81	0.0
-499	ADRA2B	ELLIPSE	20.0	#ffcccc	-283.04	1272.3	0.0
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-501	TENM1	ELLIPSE	20.0	#ffcccc	1536.75	-49.59	0.0
-502	OR3A2	ELLIPSE	20.0	#ffcccc	-125.85	-802.98	0.0
-503	OR11G2	ELLIPSE	20.0	#ffcccc	-29.94	-879.54	0.0
-504	OR2T7	ELLIPSE	20.0	#ffcccc	29.62	-884.97	0.0
-505	TRAPPC11	ELLIPSE	20.0	#ffcccc	800.87	-132.57	0.0
-506	LIPA	ELLIPSE	20.0	#ffcccc	1424.5	-2652.47	0.0
-507	EBAG9	ELLIPSE	20.0	#ffcccc	-35.49	705.69	0.0
-508	ADA	ELLIPSE	20.0	#ffcccc	-174.99	-139.57	0.0
-509	ZNF385A	ELLIPSE	20.0	#ffcccc	305.48	995.22	0.0
-510	IFNAR2	ELLIPSE	20.0	#ffcccc	265.92	345.39	0.0
-511	TREM2	ELLIPSE	20.0	#ffcccc	826.95	472.66	0.0
-512	ARL4C	ELLIPSE	20.0	#ffcccc	-464.87	782.74	0.0
-513	TNRC6B	ELLIPSE	20.0	#ffcccc	-388.19	724.82	0.0
-514	AGO4	ELLIPSE	20.0	#ffcccc	-367.03	490.07	0.0
-515	CDH18	ELLIPSE	20.0	#ffcccc	139.37	890.55	0.0
-516	ADGRA2	ELLIPSE	20.0	#ffcccc	94.22	946.2	0.0
-517	CRYAB	ELLIPSE	20.0	#ffcccc	108.66	529.92	0.0
-518	MAP3K15	ELLIPSE	20.0	#ffcccc	966.02	622.33	0.0
-519	TNFSF13B	ELLIPSE	20.0	#ffcccc	648.98	598.03	0.0
-520	STIM2	ELLIPSE	20.0	#ffcccc	1160.07	642.18	0.0
-521	LRRC41	ELLIPSE	20.0	#ffcccc	-743.52	765.77	0.0
-522	BTBD6	ELLIPSE	20.0	#ffcccc	-782.21	1106.95	0.0
-523	ARID5A	ELLIPSE	20.0	#ffcccc	-630.0	710.83	0.0
-524	DPM3	ELLIPSE	20.0	#ffcccc	-868.85	1583.89	0.0
-525	ETS2	ELLIPSE	20.0	#ffcccc	-405.25	863.21	0.0
-526	COA3	ELLIPSE	20.0	#ffcccc	-1382.2	170.47	0.0
-527	COX14	ELLIPSE	20.0	#ffcccc	-1233.32	160.61	0.0
-528	COX7B2	ELLIPSE	20.0	#ffcccc	-1061.27	57.5	0.0
-529	NTPCR	ELLIPSE	20.0	#ffcccc	-370.59	-466.8	0.0
-530	DYRK1B	ELLIPSE	20.0	#ffcccc	667.49	1195.57	0.0
-531	EGLN2	ELLIPSE	20.0	#ffcccc	-1059.51	694.7	0.0
-532	VARS2	ELLIPSE	20.0	#ffcccc	-1021.66	-181.25	0.0
-533	SMIM20	ELLIPSE	20.0	#ffcccc	-876.02	-488.09	0.0
-534	NAXE	ELLIPSE	20.0	#ffcccc	1467.31	-504.84	0.0
-535	GBE1	ELLIPSE	20.0	#ffcccc	1530.93	-585.56	0.0
-536	DOLPP1	ELLIPSE	20.0	#ffcccc	-905.83	1732.78	0.0
-537	PI4KB	ELLIPSE	20.0	#ffcccc	-117.47	1323.8	0.0
-538	BCKDK	ELLIPSE	20.0	#ffcccc	-903.28	783.05	0.0
-539	TMED5	ELLIPSE	20.0	#ffcccc	59.45	1155.17	0.0
-540	WNT5B	ELLIPSE	20.0	#ffcccc	-3.1	1039.35	0.0
-541	ADGRL4	ELLIPSE	20.0	#ffcccc	1656.84	321.66	0.0
-542	CD63	ELLIPSE	20.0	#ffcccc	1737.63	264.0	0.0
-543	PLEKHG6	ELLIPSE	20.0	#ffcccc	183.56	-436.93	0.0
-544	FOXO6	ELLIPSE	20.0	#ffcccc	-122.45	1209.79	0.0
-545	FOXP4	ELLIPSE	20.0	#ffcccc	-1526.93	-2312.8	0.0
-546	FOXP2	ELLIPSE	20.0	#ffcccc	-1449.27	-2375.33	0.0
-547	BAK1	ELLIPSE	20.0	#ffcccc	-1037.07	-429.15	0.0
-548	LYPLA2	ELLIPSE	20.0	#ffcccc	-1494.12	2.79	0.0
-549	KAZN	ELLIPSE	20.0	#ffcccc	406.24	1163.51	0.0
-550	ERC1	ELLIPSE	20.0	#ffcccc	255.74	933.92	0.0
-551	SRM	ELLIPSE	20.0	#ffcccc	-621.43	-3.22	0.0
-552	TCOF1	ELLIPSE	20.0	#ffcccc	173.74	-245.45	0.0
-553	RAD54L2	ELLIPSE	20.0	#ffcccc	-890.72	890.85	0.0
-554	C7orf50	ELLIPSE	20.0	#ffcccc	-191.38	-275.47	0.0
-555	ZRSR2P1	ELLIPSE	20.0	#ffcccc	-490.23	-725.97	0.0
-556	BTBD3	ELLIPSE	20.0	#ffcccc	-927.86	1313.17	0.0
-557	CLDN3	ELLIPSE	20.0	#ffcccc	1436.95	-807.27	0.0
-558	CLDN2	ELLIPSE	20.0	#ffcccc	1519.17	-742.7	0.0
-559	CTSV	ELLIPSE	20.0	#ffcccc	576.86	418.2	0.0
-560	SOCS4	ELLIPSE	20.0	#ffcccc	-940.81	699.4	0.0
-561	GPX8	ELLIPSE	20.0	#ffcccc	-1971.46	217.8	0.0
-562	NFIC	ELLIPSE	20.0	#ffcccc	-332.24	1113.28	0.0
-563	MAMLD1	ELLIPSE	20.0	#ffcccc	-387.27	992.89	0.0
-564	ZNF638	ELLIPSE	20.0	#ffcccc	-751.71	-2670.28	0.0
-565	SENP6	ELLIPSE	20.0	#ffcccc	-824.3	-2602.69	0.0
-566	RWDD4	ELLIPSE	20.0	#ffcccc	-895.47	-193.19	0.0
-567	ATP2B1	ELLIPSE	20.0	#ffcccc	37.45	707.27	0.0
-568	ZNF746	ELLIPSE	20.0	#ffcccc	-189.29	-356.66	0.0
-569	HSPB6	ELLIPSE	20.0	#ffcccc	381.07	707.71	0.0
-570	CALU	ELLIPSE	20.0	#ffcccc	1405.8	-594.06	0.0
-571	SARS2	ELLIPSE	20.0	#ffcccc	1470.02	-669.57	0.0
-572	CIC	ELLIPSE	20.0	#ffcccc	-965.79	907.27	0.0
+0	HSPB6	ELLIPSE	2.5	#ffcccc	496.75	683.82	0.0
+1	CRYAB	ELLIPSE	2.5	#ffcccc	342.36	550.18	0.0
+2	TARBP1	ELLIPSE	2.5	#ffcccc	633.25	351.66	0.0
+3	BRIX1	ELLIPSE	2.5	#ffcccc	627.0	197.84	0.0
+4	DDX24	ELLIPSE	2.5	#ffcccc	681.49	177.02	0.0
+5	RPL26	ELLIPSE	2.5	#ffcccc	552.51	160.54	0.0
+6	RPL3	ELLIPSE	2.5	#ffcccc	509.95	124.3	0.0
+7	RPL13A	ELLIPSE	2.5	#ffcccc	519.98	149.72	0.0
+8	RPL23	ELLIPSE	2.5	#ffcccc	538.14	85.03	0.0
+9	WDR3	ELLIPSE	2.5	#ffcccc	487.3	172.58	0.0
+10	PUS7L	ELLIPSE	2.5	#ffcccc	472.13	330.16	0.0
+11	VAMP3	ELLIPSE	2.5	#ffcccc	412.52	-46.29	0.0
+12	BAIAP2L2	ELLIPSE	2.5	#ffcccc	204.48	-311.68	0.0
+13	FAM169A	ELLIPSE	2.5	#ffcccc	73.31	59.37	0.0
+14	MYO9B	ELLIPSE	2.5	#ffcccc	756.11	366.87	0.0
+15	PKN2	ELLIPSE	2.5	#ffcccc	937.28	39.21	0.0
+16	SGIP1	ELLIPSE	2.5	#ffcccc	125.02	-130.87	0.0
+17	RPS27A	ELLIPSE	2.5	#ffcccc	615.57	33.37	0.0
+18	UBB	ELLIPSE	2.5	#ffcccc	626.83	19.71	0.0
+19	AP2S1	ELLIPSE	2.5	#ffcccc	314.35	-227.4	0.0
+20	AP2A1	ELLIPSE	2.5	#ffcccc	203.23	-130.96	0.0
+21	VPS53	ELLIPSE	2.5	#ffcccc	935.48	145.85	0.0
+22	PICALM	ELLIPSE	2.5	#ffcccc	388.37	-245.14	0.0
+23	SNAP47	ELLIPSE	2.5	#ffcccc	-99.93	-78.59	0.0
+24	STX5	ELLIPSE	2.5	#ffcccc	197.61	-157.35	0.0
+25	PKP2	ELLIPSE	2.5	#ffcccc	1043.25	260.57	0.0
+26	BRD8	ELLIPSE	2.5	#ffcccc	870.25	151.45	0.0
+27	MRPS35	ELLIPSE	2.5	#ffcccc	712.68	21.06	0.0
+28	RPS15A	ELLIPSE	2.5	#ffcccc	582.59	92.09	0.0
+29	HSPBP1	ELLIPSE	2.5	#ffcccc	454.44	115.2	0.0
+30	RPL10	ELLIPSE	2.5	#ffcccc	652.08	121.61	0.0
+31	RPL17-C18orf32	ELLIPSE	2.5	#ffcccc	635.53	179.34	0.0
+32	RPS14	ELLIPSE	2.5	#ffcccc	545.79	38.23	0.0
+33	MRPL51	ELLIPSE	2.5	#ffcccc	499.24	-204.14	0.0
+34	RPS23	ELLIPSE	2.5	#ffcccc	596.1	64.52	0.0
+35	MRPL33	ELLIPSE	2.5	#ffcccc	654.52	6.6	0.0
+36	MRPS18B	ELLIPSE	2.5	#ffcccc	779.94	-109.39	0.0
+37	FAP	ELLIPSE	2.5	#ffcccc	-206.35	52.27	0.0
+38	THY1	ELLIPSE	2.5	#ffcccc	-151.3	105.64	0.0
+39	PDRG1	ELLIPSE	2.5	#ffcccc	279.93	285.67	0.0
+40	HSPA8	ELLIPSE	2.5	#ffcccc	475.32	-8.42	0.0
+41	CCT3	ELLIPSE	2.5	#ffcccc	592.58	-7.56	0.0
+42	CCT8	ELLIPSE	2.5	#ffcccc	558.79	-20.07	0.0
+43	PFDN5	ELLIPSE	2.5	#ffcccc	424.85	130.43	0.0
+44	VCL	ELLIPSE	2.5	#ffcccc	325.49	-182.78	0.0
+45	MANF	ELLIPSE	2.5	#ffcccc	532.44	518.94	0.0
+46	TFG	ELLIPSE	2.5	#ffcccc	55.92	20.94	0.0
+47	MYL7	ELLIPSE	2.5	#ffcccc	493.75	-598.73	0.0
+48	MYL12A	ELLIPSE	2.5	#ffcccc	784.75	-567.38	0.0
+49	WDR1	ELLIPSE	2.5	#ffcccc	195.33	236.96	0.0
+50	RAP1B	ELLIPSE	2.5	#ffcccc	122.38	-356.43	0.0
+51	ACTG1	ELLIPSE	2.5	#ffcccc	451.83	-265.46	0.0
+52	CTNNB1	ELLIPSE	2.5	#ffcccc	514.08	47.32	0.0
+53	TMED1	ELLIPSE	2.5	#ffcccc	222.25	526.13	0.0
+54	ZFPL1	ELLIPSE	2.5	#ffcccc	1150.94	6.13	0.0
+55	HSCB	ELLIPSE	2.5	#ffcccc	579.7	-400.45	0.0
+56	SARS2	ELLIPSE	2.5	#ffcccc	237.86	-360.55	0.0
+57	PMPCA	ELLIPSE	2.5	#ffcccc	215.51	-207.64	0.0
+58	IARS2	ELLIPSE	2.5	#ffcccc	519.6	-24.56	0.0
+59	TOMM40	ELLIPSE	2.5	#ffcccc	688.37	-512.59	0.0
+60	SDHB	ELLIPSE	2.5	#ffcccc	373.29	-209.01	0.0
+61	ALKBH1	ELLIPSE	2.5	#ffcccc	912.32	211.97	0.0
+62	CLP1	ELLIPSE	2.5	#ffcccc	155.61	-181.96	0.0
+63	PNN	ELLIPSE	2.5	#ffcccc	240.37	-225.31	0.0
+64	SNU13	ELLIPSE	2.5	#ffcccc	481.27	26.84	0.0
+65	RSRC2	ELLIPSE	2.5	#ffcccc	342.83	-673.66	0.0
+66	LSM2	ELLIPSE	2.5	#ffcccc	389.2	-140.96	0.0
+67	HNRNPM	ELLIPSE	2.5	#ffcccc	306.49	18.67	0.0
+68	SART1	ELLIPSE	2.5	#ffcccc	189.98	-89.84	0.0
+69	FUS	ELLIPSE	2.5	#ffcccc	361.93	-112.0	0.0
+70	HNRNPH3	ELLIPSE	2.5	#ffcccc	451.15	-65.22	0.0
+71	HNRNPA2B1	ELLIPSE	2.5	#ffcccc	370.74	24.16	0.0
+72	ARGLU1	ELLIPSE	2.5	#ffcccc	-214.29	-31.88	0.0
+73	SNRPA	ELLIPSE	2.5	#ffcccc	210.84	-21.54	0.0
+74	CASC3	ELLIPSE	2.5	#ffcccc	32.93	-146.12	0.0
+75	RNPS1	ELLIPSE	2.5	#ffcccc	246.94	-102.7	0.0
+76	ACOT8	ELLIPSE	2.5	#ffcccc	773.88	461.21	0.0
+77	STAG2	ELLIPSE	2.5	#ffcccc	569.69	-397.29	0.0
+78	JUND	ELLIPSE	2.5	#ffcccc	414.39	-373.49	0.0
+79	CCNB1	ELLIPSE	2.5	#ffcccc	701.15	81.9	0.0
+80	H2AC8	ELLIPSE	2.5	#ffcccc	558.68	-162.1	0.0
+81	HIST1H2AC	ELLIPSE	2.5	#ffcccc	583.13	-136.71	0.0
+82	TERF2	ELLIPSE	2.5	#ffcccc	512.61	-478.1	0.0
+83	ESR1	ELLIPSE	2.5	#ffcccc	445.94	-195.53	0.0
+84	SMC1A	ELLIPSE	2.5	#ffcccc	651.57	-275.21	0.0
+85	CORO1A	ELLIPSE	2.5	#ffcccc	877.2	191.0	0.0
+86	ITGAL	ELLIPSE	2.5	#ffcccc	385.38	-489.37	0.0
+87	ARHGAP9	ELLIPSE	2.5	#ffcccc	709.26	617.96	0.0
+88	ACTR3	ELLIPSE	2.5	#ffcccc	385.3	181.68	0.0
+89	POC1A	ELLIPSE	2.5	#ffcccc	777.24	274.1	0.0
+90	CAPN15	ELLIPSE	2.5	#ffcccc	782.02	498.09	0.0
+91	RNF126	ELLIPSE	2.5	#ffcccc	365.22	415.18	0.0
+92	MGA	ELLIPSE	2.5	#ffcccc	228.15	110.92	0.0
+93	RNASEK-C17orf49	ELLIPSE	2.5	#ffcccc	718.08	614.74	0.0
+94	COG3	ELLIPSE	2.5	#ffcccc	523.12	-324.64	0.0
+95	CBX3	ELLIPSE	2.5	#ffcccc	687.66	-85.84	0.0
+96	AQP9	ELLIPSE	2.5	#ffcccc	959.77	-61.21	0.0
+97	FGGY	ELLIPSE	2.5	#ffcccc	443.72	569.12	0.0
+98	GSR	ELLIPSE	2.5	#ffcccc	370.54	-302.42	0.0
+99	IBA57	ELLIPSE	2.5	#ffcccc	161.17	-692.07	0.0
+100	PDHB	ELLIPSE	2.5	#ffcccc	390.13	106.84	0.0
+101	GSTP1	ELLIPSE	2.5	#ffcccc	1071.64	92.44	0.0
+102	GPX8	ELLIPSE	2.5	#ffcccc	893.33	-291.58	0.0
+103	SNAPC2	ELLIPSE	2.5	#ffcccc	677.3	-324.43	0.0
+104	SUPT5H	ELLIPSE	2.5	#ffcccc	521.66	-79.9	0.0
+105	GTF2E2	ELLIPSE	2.5	#ffcccc	866.24	-159.51	0.0
+106	POLR3G	ELLIPSE	2.5	#ffcccc	964.47	-105.04	0.0
+107	RABAC1	ELLIPSE	2.5	#ffcccc	-165.84	-65.63	0.0
+108	NTAQ1	ELLIPSE	2.5	#ffcccc	201.35	-428.96	0.0
+109	TRIM32	ELLIPSE	2.5	#ffcccc	203.83	164.25	0.0
+110	FIS1	ELLIPSE	2.5	#ffcccc	296.75	664.49	0.0
+111	UBXN6	ELLIPSE	2.5	#ffcccc	396.54	592.96	0.0
+112	MYBPHL	ELLIPSE	2.5	#ffcccc	923.98	-663.0	0.0
+113	SEC61B	ELLIPSE	2.5	#ffcccc	497.38	192.28	0.0
+114	TEX48	ELLIPSE	2.5	#ffcccc	667.42	112.87	0.0
+115	UBE2J2	ELLIPSE	2.5	#ffcccc	422.17	298.46	0.0
+116	SRP72	ELLIPSE	2.5	#ffcccc	509.51	267.15	0.0
+117	SRP9	ELLIPSE	2.5	#ffcccc	523.81	212.29	0.0
+118	RPS10-NUDT3	ELLIPSE	2.5	#ffcccc	647.87	82.85	0.0
+119	RPS7	ELLIPSE	2.5	#ffcccc	583.11	112.49	0.0
+120	RPS19	ELLIPSE	2.5	#ffcccc	600.87	84.59	0.0
+121	RPS3	ELLIPSE	2.5	#ffcccc	545.1	54.3	0.0
+122	RACK1	ELLIPSE	2.5	#ffcccc	522.35	72.17	0.0
+123	RPL36A	ELLIPSE	2.5	#ffcccc	638.6	159.59	0.0
+124	RPS10	ELLIPSE	2.5	#ffcccc	557.18	91.72	0.0
+125	RPS27	ELLIPSE	2.5	#ffcccc	594.2	148.48	0.0
+126	RPL24	ELLIPSE	2.5	#ffcccc	607.46	131.87	0.0
+127	RPL7	ELLIPSE	2.5	#ffcccc	538.11	140.23	0.0
+128	RPL38	ELLIPSE	2.5	#ffcccc	490.9	133.47	0.0
+129	RPL22	ELLIPSE	2.5	#ffcccc	603.24	210.78	0.0
+130	RPL18	ELLIPSE	2.5	#ffcccc	573.93	60.88	0.0
+131	RPL7A	ELLIPSE	2.5	#ffcccc	554.1	125.75	0.0
+132	RPL27	ELLIPSE	2.5	#ffcccc	490.92	94.66	0.0
+133	RPL39	ELLIPSE	2.5	#ffcccc	580.09	163.73	0.0
+134	SFXN3	ELLIPSE	2.5	#ffcccc	525.73	-752.19	0.0
+135	UQCRQ	ELLIPSE	2.5	#ffcccc	272.83	-241.02	0.0
+136	NUFIP2	ELLIPSE	2.5	#ffcccc	718.45	-47.05	0.0
+137	C1QBP	ELLIPSE	2.5	#ffcccc	553.33	-224.14	0.0
+138	NOP56	ELLIPSE	2.5	#ffcccc	566.36	-53.12	0.0
+139	UBAP2L	ELLIPSE	2.5	#ffcccc	351.68	-377.77	0.0
+140	GP1BB	ELLIPSE	2.5	#ffcccc	1029.84	471.85	0.0
+141	WDR76	ELLIPSE	2.5	#ffcccc	679.89	132.73	0.0
+142	SSBP1	ELLIPSE	2.5	#ffcccc	627.24	-49.26	0.0
+143	MAGED2	ELLIPSE	2.5	#ffcccc	-46.65	-363.07	0.0
+144	CHCHD2	ELLIPSE	2.5	#ffcccc	569.69	-606.92	0.0
+145	PHB1	ELLIPSE	2.5	#ffcccc	412.13	-81.07	0.0
+146	TMEM97	ELLIPSE	2.5	#ffcccc	17.89	-635.85	0.0
+147	GUK1	ELLIPSE	2.5	#ffcccc	151.08	11.94	0.0
+148	JADE1	ELLIPSE	2.5	#ffcccc	-85.84	190.69	0.0
+149	YJU2	ELLIPSE	2.5	#ffcccc	-81.66	-132.88	0.0
+150	ING4	ELLIPSE	2.5	#ffcccc	155.51	117.36	0.0
+151	ZPR1	ELLIPSE	2.5	#ffcccc	-59.65	17.66	0.0
+152	IL10RA	ELLIPSE	2.5	#ffcccc	-66.63	-81.51	0.0
+153	GLI1	ELLIPSE	2.5	#ffcccc	779.93	-208.28	0.0
+154	SEM1	ELLIPSE	2.5	#ffcccc	548.81	-141.83	0.0
+155	PSMB10	ELLIPSE	2.5	#ffcccc	567.24	-99.28	0.0
+156	PSMB5	ELLIPSE	2.5	#ffcccc	587.87	-80.0	0.0
+157	SUFU	ELLIPSE	2.5	#ffcccc	821.8	-176.27	0.0
+158	ITFG2	ELLIPSE	2.5	#ffcccc	532.39	189.58	0.0
+159	BTN2A1	ELLIPSE	2.5	#ffcccc	895.81	-411.21	0.0
+160	ATP6V1H	ELLIPSE	2.5	#ffcccc	355.8	-11.3	0.0
+161	ATP6V0B	ELLIPSE	2.5	#ffcccc	402.13	73.56	0.0
+162	RHEB	ELLIPSE	2.5	#ffcccc	363.59	447.27	0.0
+163	LAMTOR4	ELLIPSE	2.5	#ffcccc	310.8	243.46	0.0
+164	BMT2	ELLIPSE	2.5	#ffcccc	466.87	374.52	0.0
+165	WDR24	ELLIPSE	2.5	#ffcccc	157.14	220.54	0.0
+166	NME2	ELLIPSE	2.5	#ffcccc	534.42	-32.01	0.0
+167	MEA1	ELLIPSE	2.5	#ffcccc	10.54	123.13	0.0
+168	GPLD1	ELLIPSE	2.5	#ffcccc	239.39	205.77	0.0
+169	LY6H	ELLIPSE	2.5	#ffcccc	-38.62	-370.22	0.0
+170	CPM	ELLIPSE	2.5	#ffcccc	1123.81	94.0	0.0
+171	CNTN5	ELLIPSE	2.5	#ffcccc	-212.09	-99.69	0.0
+172	PIGW	ELLIPSE	2.5	#ffcccc	796.5	558.58	0.0
+173	EIF1B	ELLIPSE	2.5	#ffcccc	680.27	-1.3	0.0
+174	EIF3L	ELLIPSE	2.5	#ffcccc	548.58	-8.51	0.0
+175	EIF3CL	ELLIPSE	2.5	#ffcccc	718.2	80.71	0.0
+176	EIF3C	ELLIPSE	2.5	#ffcccc	665.33	158.22	0.0
+177	EIF1	ELLIPSE	2.5	#ffcccc	707.07	130.48	0.0
+178	EIF3A	ELLIPSE	2.5	#ffcccc	629.05	124.29	0.0
+179	EIF3G	ELLIPSE	2.5	#ffcccc	514.98	96.94	0.0
+180	TCEANC2	ELLIPSE	2.5	#ffcccc	770.05	-591.89	0.0
+181	POLR2G	ELLIPSE	2.5	#ffcccc	592.0	-162.66	0.0
+182	TTR	ELLIPSE	2.5	#ffcccc	-191.16	30.43	0.0
+183	ITM2B	ELLIPSE	2.5	#ffcccc	-67.36	444.46	0.0
+184	TBPL1	ELLIPSE	2.5	#ffcccc	996.45	-3.45	0.0
+185	GTF2H2	ELLIPSE	2.5	#ffcccc	824.3	-88.41	0.0
+186	CCNE1	ELLIPSE	2.5	#ffcccc	655.1	-137.16	0.0
+187	FGF23	ELLIPSE	2.5	#ffcccc	926.16	39.73	0.0
+188	MET	ELLIPSE	2.5	#ffcccc	676.9	-154.48	0.0
+189	KDR	ELLIPSE	2.5	#ffcccc	851.97	247.61	0.0
+190	FGFR1	ELLIPSE	2.5	#ffcccc	886.37	106.3	0.0
+191	GRIA1	ELLIPSE	2.5	#ffcccc	210.47	-270.12	0.0
+192	TRAPPC9	ELLIPSE	2.5	#ffcccc	310.94	651.01	0.0
+193	TRAF3	ELLIPSE	2.5	#ffcccc	305.63	-244.55	0.0
+194	TWIST1	ELLIPSE	2.5	#ffcccc	702.54	-654.01	0.0
+195	FOXO3	ELLIPSE	2.5	#ffcccc	349.48	-170.42	0.0
+196	PLA2G12A	ELLIPSE	2.5	#ffcccc	555.06	-417.85	0.0
+197	PEDS1-UBE2V1	ELLIPSE	2.5	#ffcccc	707.02	-147.37	0.0
+198	PLD4	ELLIPSE	2.5	#ffcccc	861.61	-433.07	0.0
+199	PLD3	ELLIPSE	2.5	#ffcccc	1007.86	-317.48	0.0
+200	LPCAT1	ELLIPSE	2.5	#ffcccc	1042.63	-160.24	0.0
+201	SRPK3	ELLIPSE	2.5	#ffcccc	424.63	423.89	0.0
+202	SAFB	ELLIPSE	2.5	#ffcccc	177.68	33.06	0.0
+203	RBM10	ELLIPSE	2.5	#ffcccc	242.95	-134.97	0.0
+204	MBNL2	ELLIPSE	2.5	#ffcccc	-252.34	74.55	0.0
+205	FUBP1	ELLIPSE	2.5	#ffcccc	174.64	-98.22	0.0
+206	RBM17	ELLIPSE	2.5	#ffcccc	51.09	-85.72	0.0
+207	CTNNBL1	ELLIPSE	2.5	#ffcccc	281.85	-80.39	0.0
+208	MFAP1	ELLIPSE	2.5	#ffcccc	180.47	-145.75	0.0
+209	HNRNPA3	ELLIPSE	2.5	#ffcccc	204.24	69.56	0.0
+210	SF1	ELLIPSE	2.5	#ffcccc	277.26	-127.12	0.0
+211	HNRNPA1	ELLIPSE	2.5	#ffcccc	374.07	-0.46	0.0
+212	FMC1-LUC7L2	ELLIPSE	2.5	#ffcccc	-93.92	-115.27	0.0
+213	DDX39B	ELLIPSE	2.5	#ffcccc	340.73	-34.8	0.0
+214	DDX46	ELLIPSE	2.5	#ffcccc	52.88	-202.01	0.0
+215	SFPQ	ELLIPSE	2.5	#ffcccc	162.58	-2.73	0.0
+216	SNRPB2	ELLIPSE	2.5	#ffcccc	144.87	-42.35	0.0
+217	SF3B5	ELLIPSE	2.5	#ffcccc	238.26	33.32	0.0
+218	ATP5F1E	ELLIPSE	2.5	#ffcccc	373.36	-291.05	0.0
+219	SMARCA4	ELLIPSE	2.5	#ffcccc	614.81	-223.27	0.0
+220	JARID2	ELLIPSE	2.5	#ffcccc	486.48	-152.8	0.0
+221	PPA2	ELLIPSE	2.5	#ffcccc	423.13	-201.03	0.0
+222	COX6C	ELLIPSE	2.5	#ffcccc	308.41	-158.97	0.0
+223	NDUFB10	ELLIPSE	2.5	#ffcccc	204.82	-92.67	0.0
+224	UQCR11	ELLIPSE	2.5	#ffcccc	165.26	-302.77	0.0
+225	COX7C	ELLIPSE	2.5	#ffcccc	437.33	-68.95	0.0
+226	CLPP	ELLIPSE	2.5	#ffcccc	331.26	-95.18	0.0
+227	TBRG4	ELLIPSE	2.5	#ffcccc	315.86	-509.92	0.0
+228	GRSF1	ELLIPSE	2.5	#ffcccc	838.05	-84.51	0.0
+229	HINT2	ELLIPSE	2.5	#ffcccc	-55.81	129.46	0.0
+230	PIN1	ELLIPSE	2.5	#ffcccc	122.36	90.8	0.0
+231	CCDC97	ELLIPSE	2.5	#ffcccc	100.49	355.24	0.0
+232	DNAJC8	ELLIPSE	2.5	#ffcccc	194.05	-36.2	0.0
+233	HTATSF1	ELLIPSE	2.5	#ffcccc	127.8	-182.22	0.0
+234	CANX	ELLIPSE	2.5	#ffcccc	489.56	-182.45	0.0
+235	HLA-DRA	ELLIPSE	2.5	#ffcccc	226.85	-38.8	0.0
+236	HLA-DQB2	ELLIPSE	2.5	#ffcccc	271.76	33.47	0.0
+237	KCNH2	ELLIPSE	2.5	#ffcccc	26.31	-180.7	0.0
+238	CISD2	ELLIPSE	2.5	#ffcccc	-22.11	32.97	0.0
+239	PRKCD	ELLIPSE	2.5	#ffcccc	298.07	-83.71	0.0
+240	NCOR2	ELLIPSE	2.5	#ffcccc	393.84	-55.69	0.0
+241	IRF3	ELLIPSE	2.5	#ffcccc	352.65	120.45	0.0
+242	JPT2	ELLIPSE	2.5	#ffcccc	964.41	-688.34	0.0
+243	STMN1	ELLIPSE	2.5	#ffcccc	564.26	-531.67	0.0
+244	VGF	ELLIPSE	2.5	#ffcccc	1175.25	-16.07	0.0
+245	AP1B1	ELLIPSE	2.5	#ffcccc	339.71	-185.54	0.0
+246	RAB5A	ELLIPSE	2.5	#ffcccc	46.07	-434.85	0.0
+247	RAB8B	ELLIPSE	2.5	#ffcccc	-201.18	15.14	0.0
+248	SIPA1L2	ELLIPSE	2.5	#ffcccc	75.04	-665.27	0.0
+249	ABHD17A	ELLIPSE	2.5	#ffcccc	86.24	455.71	0.0
+250	ABHD17C	ELLIPSE	2.5	#ffcccc	986.11	186.32	0.0
+251	SLX1A	ELLIPSE	2.5	#ffcccc	595.01	-276.17	0.0
+252	FANCF	ELLIPSE	2.5	#ffcccc	738.77	-400.79	0.0
+253	XRCC3	ELLIPSE	2.5	#ffcccc	389.58	144.81	0.0
+254	ERCC4	ELLIPSE	2.5	#ffcccc	769.79	-296.41	0.0
+255	TUBG2	ELLIPSE	2.5	#ffcccc	398.0	382.74	0.0
+256	TOPORS	ELLIPSE	2.5	#ffcccc	-41.26	480.19	0.0
+257	BLOC1S2	ELLIPSE	2.5	#ffcccc	-60.83	-14.91	0.0
+258	NME7	ELLIPSE	2.5	#ffcccc	702.29	33.34	0.0
+259	CIAO3	ELLIPSE	2.5	#ffcccc	1028.09	456.21	0.0
+260	CIAO2A	ELLIPSE	2.5	#ffcccc	1141.78	261.49	0.0
+261	MLLT6	ELLIPSE	2.5	#ffcccc	19.4	147.4	0.0
+262	ZC3H4	ELLIPSE	2.5	#ffcccc	-130.8	-534.83	0.0
+263	UBXN1	ELLIPSE	2.5	#ffcccc	602.54	371.63	0.0
+264	EIF4A1	ELLIPSE	2.5	#ffcccc	571.06	183.68	0.0
+265	TOMM34	ELLIPSE	2.5	#ffcccc	-260.87	162.24	0.0
+266	DHX30	ELLIPSE	2.5	#ffcccc	536.59	-307.77	0.0
+267	LARP1	ELLIPSE	2.5	#ffcccc	895.13	-380.74	0.0
+268	SRSF5	ELLIPSE	2.5	#ffcccc	121.72	11.09	0.0
+269	ARID1A	ELLIPSE	2.5	#ffcccc	674.61	-408.19	0.0
+270	NCL	ELLIPSE	2.5	#ffcccc	408.11	99.74	0.0
+271	H2BC8	ELLIPSE	2.5	#ffcccc	781.04	63.63	0.0
+272	YEATS2	ELLIPSE	2.5	#ffcccc	707.68	-198.2	0.0
+273	TADA2B	ELLIPSE	2.5	#ffcccc	585.85	-223.9	0.0
+274	PPP6R3	ELLIPSE	2.5	#ffcccc	26.05	-472.62	0.0
+275	WRAP53	ELLIPSE	2.5	#ffcccc	500.89	-343.74	0.0
+276	EIF6	ELLIPSE	2.5	#ffcccc	570.59	223.52	0.0
+277	BTG1	ELLIPSE	2.5	#ffcccc	73.64	-629.9	0.0
+278	AHCTF1	ELLIPSE	2.5	#ffcccc	853.1	461.18	0.0
+279	UBE2E1	ELLIPSE	2.5	#ffcccc	472.94	48.64	0.0
+280	CDK17	ELLIPSE	2.5	#ffcccc	1148.17	-458.07	0.0
+281	PPP2R5A	ELLIPSE	2.5	#ffcccc	611.67	291.27	0.0
+282	DNMT1	ELLIPSE	2.5	#ffcccc	696.75	-180.77	0.0
+283	LIN9	ELLIPSE	2.5	#ffcccc	849.73	310.87	0.0
+284	KIFC1	ELLIPSE	2.5	#ffcccc	638.56	41.64	0.0
+285	CENPU	ELLIPSE	2.5	#ffcccc	628.64	367.35	0.0
+286	BUB3	ELLIPSE	2.5	#ffcccc	454.72	149.76	0.0
+287	SKA3	ELLIPSE	2.5	#ffcccc	305.97	312.41	0.0
+288	CEP55	ELLIPSE	2.5	#ffcccc	521.59	448.26	0.0
+289	TOP2A	ELLIPSE	2.5	#ffcccc	558.75	351.26	0.0
+290	OASL	ELLIPSE	2.5	#ffcccc	549.38	229.74	0.0
+291	FBXL19	ELLIPSE	2.5	#ffcccc	349.32	359.3	0.0
+292	LMO2	ELLIPSE	2.5	#ffcccc	182.41	-255.71	0.0
+293	MAPRE2	ELLIPSE	2.5	#ffcccc	283.54	616.33	0.0
+294	HTRA2	ELLIPSE	2.5	#ffcccc	-64.45	-583.01	0.0
+295	OR13C9	ELLIPSE	2.5	#ffcccc	265.48	533.68	0.0
+296	GNAL	ELLIPSE	2.5	#ffcccc	160.62	-85.54	0.0
+297	CTSV	ELLIPSE	2.5	#ffcccc	41.42	196.03	0.0
+298	DERL1	ELLIPSE	2.5	#ffcccc	707.74	334.6	0.0
+299	SLC35B1	ELLIPSE	2.5	#ffcccc	710.08	485.03	0.0
+300	NGLY1	ELLIPSE	2.5	#ffcccc	352.2	346.7	0.0
+301	RNF139	ELLIPSE	2.5	#ffcccc	1008.23	-74.25	0.0
+302	RIPK1	ELLIPSE	2.5	#ffcccc	363.21	14.63	0.0
+303	UBE2V1	ELLIPSE	2.5	#ffcccc	287.78	149.16	0.0
+304	ELOC	ELLIPSE	2.5	#ffcccc	736.89	14.47	0.0
+305	IKBKG	ELLIPSE	2.5	#ffcccc	433.35	-25.83	0.0
+306	GUCA1C	ELLIPSE	2.5	#ffcccc	-236.31	-201.74	0.0
+307	PI4KB	ELLIPSE	2.5	#ffcccc	307.65	259.06	0.0
+308	GYS2	ELLIPSE	2.5	#ffcccc	1047.32	284.07	0.0
+309	GMPPA	ELLIPSE	2.5	#ffcccc	842.24	329.83	0.0
+310	GBE1	ELLIPSE	2.5	#ffcccc	973.32	361.61	0.0
+311	PPP4R4	ELLIPSE	2.5	#ffcccc	445.43	549.09	0.0
+312	WNT8A	ELLIPSE	2.5	#ffcccc	520.63	520.71	0.0
+313	DVL1	ELLIPSE	2.5	#ffcccc	541.2	242.29	0.0
+314	CACNG8	ELLIPSE	2.5	#ffcccc	592.85	-152.14	0.0
+315	AXIN1	ELLIPSE	2.5	#ffcccc	428.62	78.05	0.0
+316	USP22	ELLIPSE	2.5	#ffcccc	670.26	-95.27	0.0
+317	SAP130	ELLIPSE	2.5	#ffcccc	829.17	-211.9	0.0
+318	SGF29	ELLIPSE	2.5	#ffcccc	519.22	-13.6	0.0
+319	KPNA3	ELLIPSE	2.5	#ffcccc	-252.88	-70.05	0.0
+320	RCC1	ELLIPSE	2.5	#ffcccc	258.74	368.74	0.0
+321	SLC30A4	ELLIPSE	2.5	#ffcccc	544.23	-499.53	0.0
+322	C19orf25	ELLIPSE	2.5	#ffcccc	-10.17	-15.85	0.0
+323	KCNAB1	ELLIPSE	2.5	#ffcccc	-35.36	278.5	0.0
+324	MAF1	ELLIPSE	2.5	#ffcccc	616.6	79.04	0.0
+325	CARM1	ELLIPSE	2.5	#ffcccc	318.08	-44.43	0.0
+326	GAPVD1	ELLIPSE	2.5	#ffcccc	101.57	-310.12	0.0
+327	FBXO6	ELLIPSE	2.5	#ffcccc	648.16	-330.58	0.0
+328	GBA1	ELLIPSE	2.5	#ffcccc	700.56	-282.97	0.0
+329	FKBP9	ELLIPSE	2.5	#ffcccc	442.44	-147.26	0.0
+330	PCBP4	ELLIPSE	2.5	#ffcccc	-17.31	-206.58	0.0
+331	KCNQ4	ELLIPSE	2.5	#ffcccc	482.51	219.98	0.0
+332	ITGAE	ELLIPSE	2.5	#ffcccc	56.53	-632.14	0.0
+333	ITGA9	ELLIPSE	2.5	#ffcccc	294.12	-715.67	0.0
+334	MED15	ELLIPSE	2.5	#ffcccc	449.86	28.34	0.0
+335	ANGPTL4	ELLIPSE	2.5	#ffcccc	195.31	173.92	0.0
+336	RXRA	ELLIPSE	2.5	#ffcccc	354.21	-195.72	0.0
+337	CD247	ELLIPSE	2.5	#ffcccc	332.25	294.76	0.0
+338	KRT18	ELLIPSE	2.5	#ffcccc	216.79	636.9	0.0
+339	CETN2	ELLIPSE	2.5	#ffcccc	644.93	-78.9	0.0
+340	PRKDC	ELLIPSE	2.5	#ffcccc	675.41	33.99	0.0
+341	ADGRL4	ELLIPSE	2.5	#ffcccc	275.6	625.95	0.0
+342	PLCB4	ELLIPSE	2.5	#ffcccc	580.8	310.82	0.0
+343	EFNA5	ELLIPSE	2.5	#ffcccc	1032.53	-133.77	0.0
+344	BDNF	ELLIPSE	2.5	#ffcccc	993.24	-142.84	0.0
+345	KIF1B	ELLIPSE	2.5	#ffcccc	941.47	-71.62	0.0
+346	NBAS	ELLIPSE	2.5	#ffcccc	617.88	-277.98	0.0
+347	KIF3C	ELLIPSE	2.5	#ffcccc	850.31	-300.19	0.0
+348	KIF5A	ELLIPSE	2.5	#ffcccc	788.14	-253.15	0.0
+349	KLC2	ELLIPSE	2.5	#ffcccc	835.98	18.39	0.0
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+351	TP63	ELLIPSE	2.5	#ffcccc	1011.79	168.96	0.0
+352	RPH3A	ELLIPSE	2.5	#ffcccc	213.27	492.14	0.0
+353	FLNC	ELLIPSE	2.5	#ffcccc	233.33	-620.57	0.0
+354	PCNP	ELLIPSE	2.5	#ffcccc	602.22	-744.8	0.0
+355	ALDH8A1	ELLIPSE	2.5	#ffcccc	-126.66	-454.02	0.0
+356	APOC4-APOC2	ELLIPSE	2.5	#ffcccc	406.55	-468.64	0.0
+357	ZCRB1	ELLIPSE	2.5	#ffcccc	667.24	294.44	0.0
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+384	RIC8A	ELLIPSE	2.5	#ffcccc	803.88	301.71	0.0
+385	COPZ1	ELLIPSE	2.5	#ffcccc	260.13	-549.36	0.0
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+387	GRID2	ELLIPSE	2.5	#ffcccc	184.58	-400.9	0.0
+388	CACNA1G	ELLIPSE	2.5	#ffcccc	1038.38	-36.05	0.0
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+395	NKD2	ELLIPSE	2.5	#ffcccc	1049.24	323.28	0.0
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+402	LGR6	ELLIPSE	2.5	#ffcccc	36.1	233.72	0.0
+403	CHMP6	ELLIPSE	2.5	#ffcccc	794.85	-39.43	0.0
+404	KLHL12	ELLIPSE	2.5	#ffcccc	461.84	69.62	0.0
+405	CHMP7	ELLIPSE	2.5	#ffcccc	832.34	115.39	0.0
+406	GNPAT	ELLIPSE	2.5	#ffcccc	995.4	118.15	0.0
+407	EGLN1	ELLIPSE	2.5	#ffcccc	466.22	197.22	0.0
+408	GSPT2	ELLIPSE	2.5	#ffcccc	650.61	225.18	0.0
+409	GPS1	ELLIPSE	2.5	#ffcccc	847.36	50.65	0.0
+410	COMMD6	ELLIPSE	2.5	#ffcccc	755.61	169.53	0.0
+411	PARK7	ELLIPSE	2.5	#ffcccc	653.95	169.01	0.0
+412	UBE2F	ELLIPSE	2.5	#ffcccc	1009.33	188.17	0.0
+413	IZUMO4	ELLIPSE	2.5	#ffcccc	708.79	-536.13	0.0
+414	USP38	ELLIPSE	2.5	#ffcccc	1045.41	-322.39	0.0
+415	MYSM1	ELLIPSE	2.5	#ffcccc	665.0	-109.46	0.0
+416	UBE2E2	ELLIPSE	2.5	#ffcccc	473.77	273.47	0.0
+417	NOL10	ELLIPSE	2.5	#ffcccc	730.21	150.97	0.0
+418	UBE2A	ELLIPSE	2.5	#ffcccc	337.27	141.56	0.0
+419	JOSD2	ELLIPSE	2.5	#ffcccc	543.06	392.59	0.0
+420	ADGRG7	ELLIPSE	2.5	#ffcccc	335.94	-459.93	0.0
+421	RASA1	ELLIPSE	2.5	#ffcccc	951.4	-368.66	0.0
+422	TAF11L4	ELLIPSE	2.5	#ffcccc	1162.87	-50.2	0.0
+423	KCTD2	ELLIPSE	2.5	#ffcccc	471.03	-321.67	0.0
+424	LIN7C	ELLIPSE	2.5	#ffcccc	411.39	-597.1	0.0
+425	SYN1	ELLIPSE	2.5	#ffcccc	703.41	-690.62	0.0
+426	HSD17B12	ELLIPSE	2.5	#ffcccc	-201.11	182.97	0.0
+427	DHCR24	ELLIPSE	2.5	#ffcccc	-18.3	-147.46	0.0
+428	OAZ1	ELLIPSE	2.5	#ffcccc	709.32	-223.62	0.0
+429	TRIM52	ELLIPSE	2.5	#ffcccc	605.91	8.02	0.0
+430	TM7SF2	ELLIPSE	2.5	#ffcccc	-267.6	-47.32	0.0
+431	HAUS1	ELLIPSE	2.5	#ffcccc	85.44	-263.85	0.0
+432	CEP162	ELLIPSE	2.5	#ffcccc	475.87	-724.87	0.0
+433	SCN3A	ELLIPSE	2.5	#ffcccc	817.48	-548.71	0.0
+434	SCN3B	ELLIPSE	2.5	#ffcccc	789.06	-430.87	0.0
+435	SCN1B	ELLIPSE	2.5	#ffcccc	941.74	-243.21	0.0
+436	PLA2G4E	ELLIPSE	2.5	#ffcccc	1087.65	-396.36	0.0
+437	ABCA6	ELLIPSE	2.5	#ffcccc	-177.7	240.6	0.0
+438	ODF1	ELLIPSE	2.5	#ffcccc	1191.08	132.92	0.0
+439	GPC2	ELLIPSE	2.5	#ffcccc	755.79	-31.69	0.0
+440	HS3ST4	ELLIPSE	2.5	#ffcccc	-32.95	-333.02	0.0
+441	MARCHF7	ELLIPSE	2.5	#ffcccc	1023.15	442.17	0.0
+442	UBE4B	ELLIPSE	2.5	#ffcccc	891.9	407.9	0.0
+443	DNAI3	ELLIPSE	2.5	#ffcccc	501.39	-754.43	0.0
+444	CCDC114	ELLIPSE	2.5	#ffcccc	726.23	-269.7	0.0
+445	FABP1	ELLIPSE	2.5	#ffcccc	395.65	-343.34	0.0
+446	RGL1	ELLIPSE	2.5	#ffcccc	166.23	-448.42	0.0
+447	CHD9	ELLIPSE	2.5	#ffcccc	239.23	-255.47	0.0
+448	SNCB	ELLIPSE	2.5	#ffcccc	984.96	-550.37	0.0
+449	DNAJC5G	ELLIPSE	2.5	#ffcccc	829.53	-385.75	0.0
+450	ADH5	ELLIPSE	2.5	#ffcccc	950.57	507.76	0.0
+451	MCC	ELLIPSE	2.5	#ffcccc	750.38	76.35	0.0
+452	RPP25L	ELLIPSE	2.5	#ffcccc	296.95	-181.19	0.0
+453	NOLC1	ELLIPSE	2.5	#ffcccc	271.99	49.37	0.0
+454	ENOX2	ELLIPSE	2.5	#ffcccc	840.13	-542.42	0.0
+455	RPP40	ELLIPSE	2.5	#ffcccc	331.48	45.47	0.0
+456	INPPL1	ELLIPSE	2.5	#ffcccc	-144.67	118.83	0.0
+457	GRAP2	ELLIPSE	2.5	#ffcccc	-34.92	1.27	0.0
+458	PRDX3	ELLIPSE	2.5	#ffcccc	229.24	168.93	0.0
+459	CKB	ELLIPSE	2.5	#ffcccc	334.03	510.62	0.0
+460	ALDOA	ELLIPSE	2.5	#ffcccc	824.88	464.59	0.0
+461	PPFIBP2	ELLIPSE	2.5	#ffcccc	575.44	-703.05	0.0
+462	KAZN	ELLIPSE	2.5	#ffcccc	826.94	-586.78	0.0
+463	MARCHF2	ELLIPSE	2.5	#ffcccc	617.74	543.82	0.0
+464	TMEM256	ELLIPSE	2.5	#ffcccc	597.39	-332.25	0.0
+465	RAB29	ELLIPSE	2.5	#ffcccc	779.94	-654.52	0.0
+466	TMEM14C	ELLIPSE	2.5	#ffcccc	838.23	58.41	0.0
+467	TONSL	ELLIPSE	2.5	#ffcccc	-10.57	-277.47	0.0
+468	H1-10	ELLIPSE	2.5	#ffcccc	1139.25	-234.86	0.0
+469	CHRM1	ELLIPSE	2.5	#ffcccc	70.38	233.63	0.0
+470	EDN3	ELLIPSE	2.5	#ffcccc	920.71	100.42	0.0
+471	LPAR4	ELLIPSE	2.5	#ffcccc	-193.25	-58.63	0.0
+472	GABARAP	ELLIPSE	2.5	#ffcccc	783.31	295.59	0.0
+473	FNIP1	ELLIPSE	2.5	#ffcccc	490.14	310.83	0.0
+474	TBC1D25	ELLIPSE	2.5	#ffcccc	501.72	556.76	0.0
+475	ATG5	ELLIPSE	2.5	#ffcccc	1100.27	-256.32	0.0
+476	LCMT2	ELLIPSE	2.5	#ffcccc	-4.28	-540.72	0.0
+477	ZNF302	ELLIPSE	2.5	#ffcccc	-150.48	134.4	0.0
+478	B4GAT1	ELLIPSE	2.5	#ffcccc	654.53	475.96	0.0
+479	PRELP	ELLIPSE	2.5	#ffcccc	645.32	714.28	0.0
+480	LARGE2	ELLIPSE	2.5	#ffcccc	651.74	-487.15	0.0
+481	FTSJ1	ELLIPSE	2.5	#ffcccc	583.77	277.04	0.0
+482	RHNO1	ELLIPSE	2.5	#ffcccc	642.9	-656.21	0.0
+483	ZNF746	ELLIPSE	2.5	#ffcccc	198.31	-547.04	0.0
+484	KLHL2	ELLIPSE	2.5	#ffcccc	324.78	217.62	0.0
+485	ATAD5	ELLIPSE	2.5	#ffcccc	-97.61	-174.66	0.0
+486	DNAJC1	ELLIPSE	2.5	#ffcccc	277.34	320.15	0.0
+487	RAB4B	ELLIPSE	2.5	#ffcccc	1058.39	38.64	0.0
+488	ECT2L	ELLIPSE	2.5	#ffcccc	511.29	-581.37	0.0
+489	CFAP45	ELLIPSE	2.5	#ffcccc	1075.9	12.64	0.0
+490	CFAP53	ELLIPSE	2.5	#ffcccc	992.26	102.94	0.0
+491	CNPPD1	ELLIPSE	2.5	#ffcccc	558.43	-598.64	0.0
+492	STIL	ELLIPSE	2.5	#ffcccc	167.53	532.78	0.0
+493	B3GNT4	ELLIPSE	2.5	#ffcccc	243.99	594.14	0.0
+494	KDM3A	ELLIPSE	2.5	#ffcccc	600.3	-555.8	0.0
+495	FAM3A	ELLIPSE	2.5	#ffcccc	-65.27	490.07	0.0
+496	SNX15	ELLIPSE	2.5	#ffcccc	250.84	697.5	0.0
+497	DNAJC25	ELLIPSE	2.5	#ffcccc	188.39	329.68	0.0
+498	PELI3	ELLIPSE	2.5	#ffcccc	-81.64	398.5	0.0
+499	CD6	ELLIPSE	2.5	#ffcccc	-4.7	301.21	0.0
+500	CD40LG	ELLIPSE	2.5	#ffcccc	420.1	-293.14	0.0
+501	ZYX	ELLIPSE	2.5	#ffcccc	-57.34	26.27	0.0
+502	TBC1D10B	ELLIPSE	2.5	#ffcccc	-161.02	-253.3	0.0
+503	DPH5	ELLIPSE	2.5	#ffcccc	-57.25	-454.25	0.0
+504	RTN4IP1	ELLIPSE	2.5	#ffcccc	129.09	463.22	0.0
+505	COA3	ELLIPSE	2.5	#ffcccc	331.05	276.93	0.0
+506	PRKCH	ELLIPSE	2.5	#ffcccc	12.79	-528.9	0.0
+507	ADRA2B	ELLIPSE	2.5	#ffcccc	413.14	-688.04	0.0
+508	ADGRG6	ELLIPSE	2.5	#ffcccc	-244.42	264.01	0.0
+509	OR3A2	ELLIPSE	2.5	#ffcccc	-219.19	-442.99	0.0
+510	OR2T5	ELLIPSE	2.5	#ffcccc	-71.59	-166.96	0.0
+511	OR11G2	ELLIPSE	2.5	#ffcccc	450.02	688.45	0.0
+512	OR10K2	ELLIPSE	2.5	#ffcccc	163.09	-647.49	0.0
+513	OR52A5	ELLIPSE	2.5	#ffcccc	650.63	-571.45	0.0
+514	OR9A4	ELLIPSE	2.5	#ffcccc	1027.78	-221.06	0.0
+515	TRAPPC11	ELLIPSE	2.5	#ffcccc	447.67	701.38	0.0
+516	CLDN2	ELLIPSE	2.5	#ffcccc	1048.82	-451.4	0.0
+517	CLDN3	ELLIPSE	2.5	#ffcccc	1043.11	269.29	0.0
+518	WHRN	ELLIPSE	2.5	#ffcccc	82.85	588.25	0.0
+519	LIPA	ELLIPSE	2.5	#ffcccc	39.18	-408.27	0.0
+520	EBAG9	ELLIPSE	2.5	#ffcccc	-18.18	377.51	0.0
+521	ZNF385A	ELLIPSE	2.5	#ffcccc	-108.21	270.99	0.0
+522	TREM2	ELLIPSE	2.5	#ffcccc	-129.0	157.41	0.0
+523	IFNAR2	ELLIPSE	2.5	#ffcccc	-197.99	144.43	0.0
+524	FOXO6	ELLIPSE	2.5	#ffcccc	629.17	676.58	0.0
+525	ARL4C	ELLIPSE	2.5	#ffcccc	-44.34	-266.55	0.0
+526	HNRNPA1L2	ELLIPSE	2.5	#ffcccc	-86.29	-2.7	0.0
+527	MAP3K15	ELLIPSE	2.5	#ffcccc	128.81	-694.14	0.0
+528	TNFSF13B	ELLIPSE	2.5	#ffcccc	372.91	-455.35	0.0
+529	ANP32B	ELLIPSE	2.5	#ffcccc	907.23	-599.04	0.0
+530	MAGI2	ELLIPSE	2.5	#ffcccc	549.78	663.35	0.0
+531	ZNF512	ELLIPSE	2.5	#ffcccc	658.47	-407.18	0.0
+532	TNFRSF14	ELLIPSE	2.5	#ffcccc	-78.29	-524.95	0.0
+533	BTBD6	ELLIPSE	2.5	#ffcccc	378.31	513.14	0.0
+534	LRRC41	ELLIPSE	2.5	#ffcccc	1176.22	112.88	0.0
+535	AADACL2	ELLIPSE	2.5	#ffcccc	61.09	557.45	0.0
+536	CFAP43	ELLIPSE	2.5	#ffcccc	6.48	629.0	0.0
+537	ADGB	ELLIPSE	2.5	#ffcccc	349.62	674.22	0.0
+538	SLFN11	ELLIPSE	2.5	#ffcccc	-162.65	-209.92	0.0
+539	ARID5A	ELLIPSE	2.5	#ffcccc	-247.87	-61.97	0.0
+540	FOXH1	ELLIPSE	2.5	#ffcccc	8.13	-185.35	0.0
+541	TGIF2	ELLIPSE	2.5	#ffcccc	953.26	-88.6	0.0
+542	ING1	ELLIPSE	2.5	#ffcccc	1099.21	-137.98	0.0
+543	EIF2B1	ELLIPSE	2.5	#ffcccc	1126.41	-38.26	0.0
+544	AMDHD2	ELLIPSE	2.5	#ffcccc	1015.9	-37.03	0.0
+545	DPM3	ELLIPSE	2.5	#ffcccc	312.26	310.86	0.0
+546	ETS2	ELLIPSE	2.5	#ffcccc	915.4	-391.34	0.0
+547	ERC1	ELLIPSE	2.5	#ffcccc	1157.91	179.64	0.0
+548	AC098614	ELLIPSE	2.5	#ffcccc	471.8	418.07	0.0
+549	DOCK2	ELLIPSE	2.5	#ffcccc	977.19	205.81	0.0
+550	COX7B2	ELLIPSE	2.5	#ffcccc	249.52	-449.94	0.0
+551	NTPCR	ELLIPSE	2.5	#ffcccc	543.83	-551.68	0.0
+552	EGLN2	ELLIPSE	2.5	#ffcccc	610.35	678.43	0.0
+553	HDGFL2	ELLIPSE	2.5	#ffcccc	586.23	550.31	0.0
+554	VARS2	ELLIPSE	2.5	#ffcccc	112.4	227.12	0.0
+555	SMIM20	ELLIPSE	2.5	#ffcccc	-178.01	415.06	0.0
+556	C5orf49	ELLIPSE	2.5	#ffcccc	970.14	128.28	0.0
+557	SPAG6	ELLIPSE	2.5	#ffcccc	770.52	203.92	0.0
+558	NAXE	ELLIPSE	2.5	#ffcccc	965.21	-345.44	0.0
+559	DOLPP1	ELLIPSE	2.5	#ffcccc	88.08	419.98	0.0
+560	VSNL1	ELLIPSE	2.5	#ffcccc	567.28	661.97	0.0
+561	MID1IP1	ELLIPSE	2.5	#ffcccc	925.74	-511.3	0.0
+562	BCKDK	ELLIPSE	2.5	#ffcccc	831.87	435.67	0.0
+563	TMED5	ELLIPSE	2.5	#ffcccc	839.19	556.01	0.0
+564	WNT5B	ELLIPSE	2.5	#ffcccc	381.2	626.58	0.0
+565	PLEKHG6	ELLIPSE	2.5	#ffcccc	1035.01	406.42	0.0
+566	NUDT8	ELLIPSE	2.5	#ffcccc	-189.8	-338.25	0.0
+567	RAB40A	ELLIPSE	2.5	#ffcccc	906.86	557.83	0.0
+568	FOXP4	ELLIPSE	2.5	#ffcccc	209.31	379.05	0.0
+569	FOXP2	ELLIPSE	2.5	#ffcccc	268.98	-543.84	0.0
+570	MAMLD1	ELLIPSE	2.5	#ffcccc	155.6	-336.67	0.0
+571	BAK1	ELLIPSE	2.5	#ffcccc	1002.73	-584.21	0.0
+572	LYPLA2	ELLIPSE	2.5	#ffcccc	86.19	-482.04	0.0
+573	PRR3	ELLIPSE	2.5	#ffcccc	11.97	-613.59	0.0
+574	SRM	ELLIPSE	2.5	#ffcccc	217.42	-612.31	0.0
+575	TCOF1	ELLIPSE	2.5	#ffcccc	-87.97	-309.68	0.0
+576	GTF3A	ELLIPSE	2.5	#ffcccc	1101.28	-350.02	0.0
+577	DHX57	ELLIPSE	2.5	#ffcccc	1107.09	-182.41	0.0
+578	CDH18	ELLIPSE	2.5	#ffcccc	793.31	-538.98	0.0
+579	BTBD3	ELLIPSE	2.5	#ffcccc	-135.55	252.43	0.0
+580	CAPSL	ELLIPSE	2.5	#ffcccc	859.4	370.42	0.0
+581	CFAP299	ELLIPSE	2.5	#ffcccc	1104.58	-33.93	0.0
+582	CIC	ELLIPSE	2.5	#ffcccc	516.23	556.01	0.0
+583	RBM33	ELLIPSE	2.5	#ffcccc	986.18	610.51	0.0
+584	ZNF638	ELLIPSE	2.5	#ffcccc	690.16	-659.05	0.0
+585	SENP6	ELLIPSE	2.5	#ffcccc	330.67	-677.62	0.0
+586	SAMD3	ELLIPSE	2.5	#ffcccc	462.57	633.75	0.0
+587	MCRIP1	ELLIPSE	2.5	#ffcccc	383.19	-753.76	0.0
+588	TMEM25	ELLIPSE	2.5	#ffcccc	20.8	583.91	0.0
+589	NFIC	ELLIPSE	2.5	#ffcccc	565.94	-708.15	0.0
+590	C17orf58	ELLIPSE	2.5	#ffcccc	1015.97	-332.33	0.0
+591	NABP1	ELLIPSE	2.5	#ffcccc	88.5	538.3	0.0
+592	ADGRA2	ELLIPSE	2.5	#ffcccc	916.08	-374.11	0.0
+593	KIAA0513	ELLIPSE	2.5	#ffcccc	1054.89	469.97	0.0
+594	ELP2	ELLIPSE	2.5	#ffcccc	894.36	-337.98	0.0
+595	SYNPR	ELLIPSE	2.5	#ffcccc	400.03	635.7	0.0
+596	SLC6A1	ELLIPSE	2.5	#ffcccc	827.23	588.5	0.0
+597	PARP10	ELLIPSE	2.5	#ffcccc	261.13	-623.2	0.0
+598	SOCS4	ELLIPSE	2.5	#ffcccc	1032.54	-251.82	0.0
\ No newline at end of file

From 831b88e4573320b809a3160de489c0586a775d6e Mon Sep 17 00:00:00 2001
From: Iara Souza <iaradsouza1@gmail.com>
Date: Wed, 8 May 2024 14:02:05 -0300
Subject: [PATCH 24/24] fix: changed the figure 1 and 3

---
 scripts/metadata.R |  4 ++++
 scripts/network.R  | 11 ++++-------
 scripts/plots.rmd  | 40 ++++++++++++++++++++++++++++++++++++++--
 3 files changed, 46 insertions(+), 9 deletions(-)

diff --git a/scripts/metadata.R b/scripts/metadata.R
index 3a672e1..7e85ed0 100644
--- a/scripts/metadata.R
+++ b/scripts/metadata.R
@@ -27,12 +27,16 @@ ann$rin <- scale(ann$rin)[,1]
 rownames(ann) <- ann$sample_id
 ann$sample_id <- NULL
 
+# Keep the full dataframe
+ann_full <- ann
+
 # Remove samples "SRR5961961" and "SRR5961809" that appeared as outliers on robust pca analysis
 ann <- ann %>%
   filter(!(rownames(ann) %in% c("SRR5961961", "SRR5961809")))
 
 # Save (this metadata will be used in all future models)
 save(ann, file = "results/important_variables/ann.rda")
+save(ann_full, file = "results/important_variables/ann_full.rda")
 
   
 
diff --git a/scripts/network.R b/scripts/network.R
index 886be1b..34eefc4 100644
--- a/scripts/network.R
+++ b/scripts/network.R
@@ -82,9 +82,6 @@ addGraph(rdp, g)
 nodes <- read_tsv("results/networks/model_nodes.txt")
 edges <- read_delim("results/networks/model_edges.txt")
 
-nodes <- read_tsv("~/model_nodes.txt")
-edges <- read_delim("~/model_edges.txt")
-
 # Import nodes coordinates determined by vivagraph
 layout <- read.csv("results/networks/layout.csv")
 
@@ -109,16 +106,16 @@ ggraph(g, x = x, y = y) +
     data = as_data_frame(g, "vertices") %>% filter(gwas == "gwas"),
     colour = NA,
     n = 5,
-    pie_scale = 0.5,
+    pie_scale = 0.9,
   show.legend = F) +
   geom_scatterpie(
     cols = c("a", "b", "c"),
     data = as_data_frame(g, "vertices") %>% filter(gwas == "not_gwas"),
     colour = NA,
-    pie_scale = 0.2,
+    pie_scale = 0.3,
     show.legend = F
   ) +
-  geom_node_text(aes(label = alias), size = 0.9, nudge_x = 2, nudge_y = 4) + 
+  #geom_node_text(aes(label = alias), size = 1.7, nudge_x = 2, nudge_y = 4) + 
   #geom_node_label(aes(label = alias)) + 
   scale_fill_manual(values = c("#0ac80aff", "#4f4affff", "#ff822fff")) +
   coord_fixed() +
@@ -130,7 +127,7 @@ if(!dir.exists("results/plots_paper/")) {
   dir.create("results/plots_paper")
 }
 
-svg(filename = "results/plots_paper/network.svg", height = 10, width = 10)
+pdf(file = "~/Área de Trabalho/network.pdf", height = 15, width = 15)
 print(p)
 dev.off()
 
diff --git a/scripts/plots.rmd b/scripts/plots.rmd
index c79293d..5f81e80 100644
--- a/scripts/plots.rmd
+++ b/scripts/plots.rmd
@@ -355,9 +355,45 @@ ggsave("results/plots_paper/fig2C_2.png", height = 4, width = 5, dpi = 300)
 
 ```
 
-## Figure 3
+# Figure 3
 
-Figure 3 was produced on the biotype analysis, in the `summarise_biotypes.R` script.
+```{r}
+# Load enrichment data
+load("results/tx_enrich/go_terms_tx_by_group.rda")
+
+# Create a dataframe with results from OFC (female) and CG25 (male) enrichment
+df_enrich <- bind_rows(enriched_df_diff[["OFC_female"]], enriched_df_diff[["Cg25_male"]])
+
+# Parse gene ratio column
+df_enrich <- df_enrich %>%  mutate(
+  n_tag = as.numeric(sapply(strsplit(GeneRatio, split = "\\/"), "[[", 2)),
+  GeneRatio = as.numeric(Count) / n_tag
+)
+
+# Plot
+df_enrich %>% 
+  ggplot(aes(x = fct_reorder2(Description, -p.adjust, -Count), y = GeneRatio, size = Count, col = p.adjust)) +
+  geom_point() +
+  facet_grid(rows = vars(group), scales = "free_y", space = "free_y",
+             labeller = as_labeller(c(
+               "Cg25_male" = "Cg25 (male)",
+               "OFC_female" = "OFC (female)"
+             ))) +
+  force_panelsizes(rows = c(0.17, 1)) +
+  scale_color_continuous(limits = c(0, 0.05), breaks = seq(0, 0.05, 0.01)) +
+  labs(x = "", y = "Gene ratio", color = "FDR", size = "Intersection") +
+  coord_flip() + 
+  theme_bw() +
+  theme(axis.text.y = element_text(size = 9),
+        strip.text.y = element_text(size = 9))
+
+ggsave(filename = "results/plots_paper/fig3.pdf", width = 9, height = 6)
+ggsave(filename = "results/plots_paper/fig3.png", width = 9, height = 6)
+```
+
+## Figure 4
+
+Figure 4 was produced on the biotype analysis, in the `summarise_biotypes.R` script.
 
 
 # Supplementary Figures