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report.Rmd
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---
title: "DosePredict Report"
output:
html_document:
toc: true
theme: united
params:
AuthorParam: NA
CompoundParam: NA
Commentsenterd: NA
Modelname: NA
ModelParameters: NA
DosingParams: NA
SafetyParams: NA
EfficacyParams: NA
NCALimitsParams: NA
NCAtable1: NA
Efftable1: NA
SAFtable1: NA
Pkplot: NA
plotallNCA1: NA
plotSAFNCA1: NA
plotEFF1: NA
plotEFF2: NA
---
<style type="text/css">
h1.title {
font-size: 38px;
color: DarkRed;
text-align: center;
}
</style>
```{r global_options, include=FALSE}
knitr::opts_chunk$set(fig.width=12, fig.height=8, fig.path='Figs/',
echo=FALSE, warning=FALSE, message=FALSE)
```
__Date__: `r format(Sys.time(), ' %B %d, %Y')`
__Author__: `r params$AuthorParam`
__Compound ID__: `r params$CompoundParam`
__Run Comments__: `r params$Commentsenterd`
# Simulation Inputs:
## 1- Pharmacokinetic Input:
The __Pharmacokinetic model__ used is `r params$Modelname`.
The __Pharmacokinetic Parameters__ used in the simulations are:
```{r Pk Param, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$ModelParameters)
```
## 2- Dosing Input:
The __dosing infromation__ evaluated in the simulations are:
```{r Dosing, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$DosingParams)
```
## 3- Safety and Efficacy Targets:
The __Safety limits__ used in the simulations are:
```{r SafetyParams, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$SafetyParams)
```
And the __target efficacy concentration limit__ used is:
```{r Efficacy targets, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$EfficacyParams)
```
## 4- NCA Input:
The NCA calculations results are:
```{r NCA, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$NCAtable1, digits=4)
```
# Results:
## 1- Safety Calculations:
The safety calculations in relation to safety targets are:
```{r saf table, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$SAFtable1, digits=4)
```
## 2- Efficacy Calculations:
The efficacy calculations in relation to efficacy targets are:
```{r Eff table, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$Efftable1, digits=4)
```
## 3- NCA Calculations:
The NCA calculations were done within the below __NCA time frame__:
```{r NCA time fram, echo=F, warning=F}
# The `params` object is available in the document.
kable(params$NCALimitsParams)
```
# Plots:
## 1- Simulation Plot:
```{r , message = FALSE, echo = FALSE, warning=FALSE}
# The `params` object is available in the document.
ggplotly(params$Pkplot,session="knitr")
```
## 2- NCA Histograms:
```{r , message = FALSE, echo = FALSE, warning=FALSE}
# The `params` object is available in the document.
print(params$plotallNCA1)
#ggplotly(params$plotallNCA1,session="knitr")
```
## 3- Safety Histogram:
```{r , message = FALSE, echo = FALSE, warning=FALSE}
# The `params` object is available in the document.
#print(params$plotallNCA1)
ggplotly(params$plotSAFNCA1,session="knitr")
```
## 4- Efficacy Histograms:
```{r , message = FALSE, echo = FALSE, warning=FALSE}
# The `params` object is available in the document.
#print(params$plotallNCA1)
ggplotly(params$plotEFF1,session="knitr")
```
```{r , message = FALSE, echo = FALSE, warning=FALSE}
# The `params` object is available in the document.
#print(params$plotallNCA1)
ggplotly(params$plotEFF2,session="knitr")
```
END of REPORT