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The default settings for --alignment-params are optimized for PacBio HiFi reads. You suggest increasing the gap-open values f and g for ONT reads with a higher indel error rate, but it's not clear what appropriate values would be. Would be great to have a set of optimized ONT default values.
The text was updated successfully, but these errors were encountered:
Hello. Thank you for using LongTR. I tested with values -1 for f and g instead of -10 and alignments seemed more accurate, but we did not systematically test different values. Please let me know if you have any other questions.
The default settings for
--alignment-params
are optimized for PacBio HiFi reads. You suggest increasing the gap-open values f and g for ONT reads with a higher indel error rate, but it's not clear what appropriate values would be. Would be great to have a set of optimized ONT default values.The text was updated successfully, but these errors were encountered: