diff --git a/cel/BUILD.bazel b/cel/BUILD.bazel
index d3b9ae22..0c740dd8 100644
--- a/cel/BUILD.bazel
+++ b/cel/BUILD.bazel
@@ -30,6 +30,7 @@ go_library(
         "@org_golang_google_protobuf//reflect/protoreflect:go_default_library",
         "@org_golang_google_protobuf//reflect/protoregistry:go_default_library",
         "@org_golang_google_protobuf//types/descriptorpb:go_default_library",
+        "@org_golang_google_protobuf//types/dynamicpb:go_default_library",
         "@org_golang_google_genproto//googleapis/api/expr/v1alpha1:go_default_library",
     ],
     importpath = "github.com/google/cel-go/cel",
diff --git a/cel/cel_test.go b/cel/cel_test.go
index 7fdaa016..b5babe07 100644
--- a/cel/cel_test.go
+++ b/cel/cel_test.go
@@ -35,11 +35,13 @@ import (
 
 	"google.golang.org/protobuf/proto"
 	"google.golang.org/protobuf/reflect/protodesc"
+	"google.golang.org/protobuf/reflect/protoreflect"
 
 	proto2pb "github.com/google/cel-go/test/proto2pb"
 	proto3pb "github.com/google/cel-go/test/proto3pb"
 	exprpb "google.golang.org/genproto/googleapis/api/expr/v1alpha1"
 	descpb "google.golang.org/protobuf/types/descriptorpb"
+	dynamicpb "google.golang.org/protobuf/types/dynamicpb"
 )
 
 func Example() {
@@ -562,6 +564,68 @@ func TestDynamicProto(t *testing.T) {
 	}
 }
 
+func TestDynamicProto_Input(t *testing.T) {
+	b, err := ioutil.ReadFile("testdata/team.fds")
+	if err != nil {
+		t.Fatalf("ioutil.ReadFile() failed: %v", err)
+	}
+	var fds descpb.FileDescriptorSet
+	if err = proto.Unmarshal(b, &fds); err != nil {
+		t.Fatalf("proto.Unmarshal() failed: %v", err)
+	}
+	files := (&fds).GetFile()
+	fileCopy := make([]interface{}, len(files))
+	for i := 0; i < len(files); i++ {
+		fileCopy[i] = files[i]
+	}
+	pbFiles, err := protodesc.NewFiles(&fds)
+	if err != nil {
+		t.Fatalf("protodesc.NewFiles() failed: %v", err)
+	}
+	desc, err := pbFiles.FindDescriptorByName("cel.testdata.Mutant")
+	if err != nil {
+		t.Fatalf("pbFiles.FindDescriptorByName() could not find Mutant: %v", err)
+	}
+	msgDesc, ok := desc.(protoreflect.MessageDescriptor)
+	if !ok {
+		t.Fatalf("desc not convertible to MessageDescriptor: %T", desc)
+	}
+	wolverine := dynamicpb.NewMessage(msgDesc)
+	wolverine.ProtoReflect().Set(msgDesc.Fields().ByName("name"), protoreflect.ValueOfString("Wolverine"))
+	e, err := NewEnv(
+		// The following is identical to registering the FileDescriptorSet;
+		// however, it tests a different code path which aggregates individual
+		// FileDescriptorProto values together.
+		TypeDescs(fileCopy...),
+		Declarations(decls.NewVar("mutant", decls.NewObjectType("cel.testdata.Mutant"))),
+	)
+	if err != nil {
+		t.Fatalf("NewEnv() failed: %v", err)
+	}
+	src := `has(mutant.name) && mutant.name == 'Wolverine'`
+	ast, iss := e.Compile(src)
+	if iss.Err() != nil {
+		t.Fatalf("env.Compile(%s) failed: %v", src, iss.Err())
+	}
+	prg, err := e.Program(ast, EvalOptions(OptOptimize))
+	if err != nil {
+		t.Fatalf("env.Program() failed: %v", err)
+	}
+	out, _, err := prg.Eval(map[string]interface{}{
+		"mutant": wolverine,
+	})
+	if err != nil {
+		t.Fatalf("program.Eval() failed: %v", err)
+	}
+	obj, ok := out.(types.Bool)
+	if !ok {
+		t.Fatalf("unable to convert output to object: %v", out)
+	}
+	if obj != types.True {
+		t.Errorf("got %v, wanted true", out)
+	}
+}
+
 func TestGlobalVars(t *testing.T) {
 	mapStrDyn := decls.NewMapType(decls.String, decls.Dyn)
 	e, _ := NewEnv(
diff --git a/common/types/pb/type.go b/common/types/pb/type.go
index 64a56c70..c5060a46 100644
--- a/common/types/pb/type.go
+++ b/common/types/pb/type.go
@@ -198,7 +198,16 @@ func (fd *FieldDescription) Descriptor() protoreflect.FieldDescriptor {
 func (fd *FieldDescription) IsSet(target interface{}) bool {
 	switch v := target.(type) {
 	case proto.Message:
-		return v.ProtoReflect().Has(fd.desc)
+		pbRef := v.ProtoReflect()
+		pbDesc := pbRef.Descriptor()
+		if pbDesc == fd.desc.ContainingMessage() {
+			// When the target protobuf shares the same message descriptor instance as the field
+			// descriptor, use the cached field descriptor value.
+			return pbRef.Has(fd.desc)
+		}
+		// Otherwise, fallback to a dynamic lookup of the field descriptor from the target
+		// instance as an attempt to use the cached field descriptor will result in a panic.
+		return pbRef.Has(pbDesc.Fields().ByName(protoreflect.Name(fd.Name())))
 	default:
 		return false
 	}
@@ -215,7 +224,18 @@ func (fd *FieldDescription) GetFrom(target interface{}) (interface{}, error) {
 	if !ok {
 		return nil, fmt.Errorf("unsupported field selection target: (%T)%v", target, target)
 	}
-	fieldVal := v.ProtoReflect().Get(fd.desc).Interface()
+	pbRef := v.ProtoReflect()
+	pbDesc := pbRef.Descriptor()
+	var fieldVal interface{}
+	if pbDesc == fd.desc.ContainingMessage() {
+		// When the target protobuf shares the same message descriptor instance as the field
+		// descriptor, use the cached field descriptor value.
+		fieldVal = pbRef.Get(fd.desc).Interface()
+	} else {
+		// Otherwise, fallback to a dynamic lookup of the field descriptor from the target
+		// instance as an attempt to use the cached field descriptor will result in a panic.
+		fieldVal = pbRef.Get(pbDesc.Fields().ByName(protoreflect.Name(fd.Name()))).Interface()
+	}
 	switch fv := fieldVal.(type) {
 	// Fast-path return for primitive types.
 	case bool, []byte, float32, float64, int32, int64, string, uint32, uint64, protoreflect.List: