diff --git a/snuba/web/rpc/common/aggregation.py b/snuba/web/rpc/common/aggregation.py
index 228f3dd05a..5d248d51cd 100644
--- a/snuba/web/rpc/common/aggregation.py
+++ b/snuba/web/rpc/common/aggregation.py
@@ -40,13 +40,16 @@ class ExtrapolationMeta:
     avg_sampling_rate: float
 
     @staticmethod
-    def from_row(row_data: Dict[str, Any], column_label: str) -> "ExtrapolationMeta":
+    def from_row(
+        row_data: Dict[str, Any], column_label: str
+    ) -> "ExtrapolationMeta | None":
         """
         Computes the reliability and average sample rate for a column based on the extrapolation columns.
+        If the sample count is 0, we return None as we don't have any data to extrapolate.
         """
         confidence_interval = None
         average_sample_rate = 0
-        sample_count = None
+        sample_count = 0
         is_percentile = False
         percentile = 0.0
         granularity = 0.0
@@ -87,7 +90,10 @@ def from_row(row_data: Dict[str, Any], column_label: str) -> "ExtrapolationMeta"
                     sample_count = col_value
 
         reliability = Reliability.RELIABILITY_UNSPECIFIED
-        if confidence_interval is not None and sample_count is not None:
+        if confidence_interval is not None:
+            if sample_count == 0:
+                return None
+
             estimate = row_data[column_label]
             # relative confidence represents the ratio of the confidence interval to the estimate (by default it is the upper bound)
             if is_percentile:
diff --git a/snuba/web/rpc/v1/endpoint_time_series.py b/snuba/web/rpc/v1/endpoint_time_series.py
index 1b87017146..d263852fe2 100644
--- a/snuba/web/rpc/v1/endpoint_time_series.py
+++ b/snuba/web/rpc/v1/endpoint_time_series.py
@@ -173,14 +173,17 @@ def _convert_result_timeseries(
                 extrapolation_meta = ExtrapolationMeta.from_row(
                     row_data, timeseries.label
                 )
-                timeseries.data_points.append(
-                    DataPoint(
-                        data=row_data[timeseries.label],
-                        data_present=True,
-                        avg_sampling_rate=extrapolation_meta.avg_sampling_rate,
-                        reliability=extrapolation_meta.reliability,
+                if extrapolation_meta is not None:
+                    timeseries.data_points.append(
+                        DataPoint(
+                            data=row_data[timeseries.label],
+                            data_present=True,
+                            avg_sampling_rate=extrapolation_meta.avg_sampling_rate,
+                            reliability=extrapolation_meta.reliability,
+                        )
                     )
-                )
+                else:
+                    timeseries.data_points.append(DataPoint(data=0, data_present=False))
     return result_timeseries.values()
 
 
diff --git a/snuba/web/rpc/v1/endpoint_trace_item_table.py b/snuba/web/rpc/v1/endpoint_trace_item_table.py
index bcc3578257..7bece3f811 100644
--- a/snuba/web/rpc/v1/endpoint_trace_item_table.py
+++ b/snuba/web/rpc/v1/endpoint_trace_item_table.py
@@ -212,7 +212,8 @@ def _convert_results(
                 res[column_name].attribute_name = column_name
                 extrapolation_meta = ExtrapolationMeta.from_row(row, column_name)
                 if (
-                    extrapolation_meta.reliability
+                    extrapolation_meta is not None
+                    and extrapolation_meta.reliability
                     != Reliability.RELIABILITY_UNSPECIFIED
                 ):
                     res[column_name].reliabilities.append(
diff --git a/tests/web/rpc/test_aggregation.py b/tests/web/rpc/test_aggregation.py
index e582dd0edc..e6ba7e3c42 100644
--- a/tests/web/rpc/test_aggregation.py
+++ b/tests/web/rpc/test_aggregation.py
@@ -147,6 +147,7 @@ def test_get_extrapolation_meta(
     reliability: Reliability.ValueType,
 ) -> None:
     extrapolation_meta = ExtrapolationMeta.from_row(row_data, column_name)
+    assert extrapolation_meta is not None
     assert extrapolation_meta.avg_sampling_rate == average_sample_rate
     assert extrapolation_meta.reliability == reliability
 
diff --git a/tests/web/rpc/v1/test_endpoint_time_series/test_endpoint_time_series_extrapolation.py b/tests/web/rpc/v1/test_endpoint_time_series/test_endpoint_time_series_extrapolation.py
index f53c40aabd..a12ff4c226 100644
--- a/tests/web/rpc/v1/test_endpoint_time_series/test_endpoint_time_series_extrapolation.py
+++ b/tests/web/rpc/v1/test_endpoint_time_series/test_endpoint_time_series_extrapolation.py
@@ -301,6 +301,58 @@ def test_confidence_interval_zero_estimate(self) -> None:
             )
         ]
 
+    def test_confidence_interval_no_samples(self) -> None:
+        # store a a test metric with a value of 1, every second for an hour
+        granularity_secs = 120
+        query_duration = 3600
+        store_timeseries(
+            BASE_TIME,
+            1,
+            3600,
+            metrics=[DummyMetric("test_metric", get_value=lambda x: 0)],
+            measurements=[
+                DummyMeasurement("client_sample_rate", get_value=lambda s: 1)
+            ],
+        )
+
+        message = TimeSeriesRequest(
+            meta=RequestMeta(
+                project_ids=[1, 2, 3],
+                organization_id=1,
+                cogs_category="something",
+                referrer="something",
+                start_timestamp=Timestamp(seconds=int(BASE_TIME.timestamp())),
+                end_timestamp=Timestamp(
+                    seconds=int(BASE_TIME.timestamp() + query_duration)
+                ),
+            ),
+            aggregations=[
+                AttributeAggregation(
+                    aggregate=Function.FUNCTION_P50,
+                    key=AttributeKey(
+                        type=AttributeKey.TYPE_FLOAT, name="test_metric2"
+                    ),  # non-existent metric
+                    label="p50(test_metric2)",
+                    extrapolation_mode=ExtrapolationMode.EXTRAPOLATION_MODE_SAMPLE_WEIGHTED,
+                ),
+            ],
+            granularity_secs=granularity_secs,
+        )
+        response = EndpointTimeSeries().execute(message)
+        expected_buckets = [
+            Timestamp(seconds=int(BASE_TIME.timestamp()) + secs)
+            for secs in range(0, query_duration, granularity_secs)
+        ]
+        assert sorted(response.result_timeseries, key=lambda x: x.label) == [
+            TimeSeries(
+                label="p50(test_metric2)",
+                buckets=expected_buckets,
+                data_points=[
+                    DataPoint(data_present=False) for _ in range(len(expected_buckets))
+                ],
+            )
+        ]
+
     def test_count_unreliable(self) -> None:
         # store a a test metric with a value of 1, every second for an hour
         granularity_secs = 120