GO:0101020 estrogen 16-alpha-hydroxylase activity with no cross reference

[raymond91125]

See #28340.

GO:0101020 estrogen 16-alpha-hydroxylase activity lacks a published xref.

"The four major naturally occurring estrogens in women are estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4" (https://en.wikipedia.org/wiki/Estrogen). Thus, this activity may apply to 4 or more reactions, one for each estrogen substrate.

The super class activity is probably EC:1.14.14.1 unspecific monooxygenase , RHEA:17149, that is GO:0070330 aromatase activity, based on the the shared UniProt annotation of all genes annotated (EXP) with GO:0101020. RHEA:17149 has many specific reactions listed but those may not be exhaustive.

Some possible relevant RHEAs
RHEA:47204 estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47260 O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:47332 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
RHEA:53216 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

[raymond91125]

GO:0070330 aromatase activity is not XREF'ed to EC:1.14.14.1 anymore (#28295). There is now no exact match to EC:1.14.14.1.

[pgaudet]

hi @raymond91125

Please update definition and parent to match the RHEA reaction.

Thanks, Pascale