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GO:0033094 butane-1,4-diamine:2-oxoglutarate aminotransferase activity #25992

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sjm41 opened this issue Aug 30, 2023 · 0 comments
Closed
2 tasks done

GO:0033094 butane-1,4-diamine:2-oxoglutarate aminotransferase activity #25992

sjm41 opened this issue Aug 30, 2023 · 0 comments

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@sjm41
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sjm41 commented Aug 30, 2023

id: GO:0033094
name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O." [EC:2.6.1.82, GOC:mlg, RHEA:12268]
synonym: "PAT activity" RELATED []
synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82]
synonym: "putrescine transaminase activity" BROAD []
synonym: "putrescine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.82]
synonym: "putrescine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.82]
synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.82]
synonym: "YgjG" RELATED [EC:2.6.1.82]
xref: EC:2.6.1.82
xref: MetaCyc:PUTTRANSAM-RXN
xref: RHEA:12268
is_a: GO:0008483 ! transaminase activity

The EC:2.6.1.82 entry says:
Name: putrescine--2-oxoglutarate transaminase
Reaction: 2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate
Comment: The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline

The current RHEA:12268 xref describes the whole reaction:
RHEA:12268 | 2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate

while RHEA:23816 just describes the enzymatic part:
RHEA:23816 | 2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate

Suggest:

  • Change GO term name to match EC name ("putrescine--2-oxoglutarate transaminase activity")
  • Add the EC comment to the GO def.
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