diff --git a/src/design_patterns/negative_regulation.tsv b/src/design_patterns/negative_regulation.tsv
index eb5a1d4475..47802809f6 100644
--- a/src/design_patterns/negative_regulation.tsv
+++ b/src/design_patterns/negative_regulation.tsv
@@ -646,14 +646,11 @@ http://purl.obolibrary.org/obo/GO_2000961	negative regulation of cellooligosacch
 http://purl.obolibrary.org/obo/GO_2000937	negative regulation of cellotriose catabolic process	http://purl.obolibrary.org/obo/GO_2000894	cellotriose catabolic process
 http://purl.obolibrary.org/obo/GO_2000934	negative regulation of cellotriose metabolic process	http://purl.obolibrary.org/obo/GO_2000893	cellotriose metabolic process
 http://purl.obolibrary.org/obo/GO_1900286	negative regulation of cellotriose transport	http://purl.obolibrary.org/obo/GO_2001096	cellotriose transport
-http://purl.obolibrary.org/obo/GO_0031327	negative regulation of cellular biosynthetic process	http://purl.obolibrary.org/obo/GO_0044249	cellular biosynthetic process
-http://purl.obolibrary.org/obo/GO_0031330	negative regulation of cellular catabolic process	http://purl.obolibrary.org/obo/GO_0044248	cellular catabolic process
 http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization
 http://purl.obolibrary.org/obo/GO_0051245	negative regulation of cellular defense response	http://purl.obolibrary.org/obo/GO_0006968	cellular defense response
 http://purl.obolibrary.org/obo/GO_0002692	negative regulation of cellular extravasation	http://purl.obolibrary.org/obo/GO_0045123	cellular extravasation
 http://purl.obolibrary.org/obo/GO_2001030	negative regulation of cellular glucuronidation	http://purl.obolibrary.org/obo/GO_0052695	cellular glucuronidation
 http://purl.obolibrary.org/obo/GO_1900070	negative regulation of cellular hyperosmotic salinity response	http://purl.obolibrary.org/obo/GO_0071475	cellular hyperosmotic salinity response
-http://purl.obolibrary.org/obo/GO_0031324	negative regulation of cellular metabolic process	http://purl.obolibrary.org/obo/GO_0044237	cellular metabolic process
 http://purl.obolibrary.org/obo/GO_0032848	negative regulation of cellular pH reduction	http://purl.obolibrary.org/obo/GO_0051452	intracellular pH reduction
 http://purl.obolibrary.org/obo/GO_0048523	negative regulation of cellular process	http://purl.obolibrary.org/obo/GO_0009987	cellular process
 http://purl.obolibrary.org/obo/GO_1901856	negative regulation of cellular respiration	http://purl.obolibrary.org/obo/GO_0045333	cellular respiration
diff --git a/src/design_patterns/positive_regulation.tsv b/src/design_patterns/positive_regulation.tsv
index 18e5968d50..f667751e5a 100644
--- a/src/design_patterns/positive_regulation.tsv
+++ b/src/design_patterns/positive_regulation.tsv
@@ -648,14 +648,11 @@ http://purl.obolibrary.org/obo/GO_2000962	positive regulation of cellooligosacch
 http://purl.obolibrary.org/obo/GO_2000938	positive regulation of cellotriose catabolic process	http://purl.obolibrary.org/obo/GO_2000894	cellotriose catabolic process
 http://purl.obolibrary.org/obo/GO_2000935	positive regulation of cellotriose metabolic process	http://purl.obolibrary.org/obo/GO_2000893	cellotriose metabolic process
 http://purl.obolibrary.org/obo/GO_1900287	positive regulation of cellotriose transport	http://purl.obolibrary.org/obo/GO_2001096	cellotriose transport
-http://purl.obolibrary.org/obo/GO_0031328	positive regulation of cellular biosynthetic process	http://purl.obolibrary.org/obo/GO_0044249	cellular biosynthetic process
-http://purl.obolibrary.org/obo/GO_0031331	positive regulation of cellular catabolic process	http://purl.obolibrary.org/obo/GO_0044248	cellular catabolic process
 http://purl.obolibrary.org/obo/GO_0044089	positive regulation of cellular component biogenesis	http://purl.obolibrary.org/obo/GO_0044085	cellular component biogenesis
 http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization
 http://purl.obolibrary.org/obo/GO_0010186	positive regulation of cellular defense response	http://purl.obolibrary.org/obo/GO_0006968	cellular defense response
 http://purl.obolibrary.org/obo/GO_0002693	positive regulation of cellular extravasation	http://purl.obolibrary.org/obo/GO_0045123	cellular extravasation
 http://purl.obolibrary.org/obo/GO_2001031	positive regulation of cellular glucuronidation	http://purl.obolibrary.org/obo/GO_0052695	cellular glucuronidation
-http://purl.obolibrary.org/obo/GO_0031325	positive regulation of cellular metabolic process	http://purl.obolibrary.org/obo/GO_0044237	cellular metabolic process
 http://purl.obolibrary.org/obo/GO_0032849	positive regulation of cellular pH reduction	http://purl.obolibrary.org/obo/GO_0051452	intracellular pH reduction
 http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process	http://purl.obolibrary.org/obo/GO_0009987	cellular process
 http://purl.obolibrary.org/obo/GO_1901857	positive regulation of cellular respiration	http://purl.obolibrary.org/obo/GO_0045333	cellular respiration
diff --git a/src/design_patterns/regulation.tsv b/src/design_patterns/regulation.tsv
index 2b3789f770..873ce26e18 100644
--- a/src/design_patterns/regulation.tsv
+++ b/src/design_patterns/regulation.tsv
@@ -747,8 +747,6 @@ http://purl.obolibrary.org/obo/GO_2000960	regulation of cellooligosaccharide met
 http://purl.obolibrary.org/obo/GO_2000936	regulation of cellotriose catabolic process	http://purl.obolibrary.org/obo/GO_2000894	cellotriose catabolic process
 http://purl.obolibrary.org/obo/GO_2000933	regulation of cellotriose metabolic process	http://purl.obolibrary.org/obo/GO_2000893	cellotriose metabolic process
 http://purl.obolibrary.org/obo/GO_1900285	regulation of cellotriose transport	http://purl.obolibrary.org/obo/GO_2001096	cellotriose transport
-http://purl.obolibrary.org/obo/GO_0031326	regulation of cellular biosynthetic process	http://purl.obolibrary.org/obo/GO_0044249	cellular biosynthetic process
-http://purl.obolibrary.org/obo/GO_0031329	regulation of cellular catabolic process	http://purl.obolibrary.org/obo/GO_0044248	cellular catabolic process
 http://purl.obolibrary.org/obo/GO_0044087	regulation of cellular component biogenesis	http://purl.obolibrary.org/obo/GO_0044085	cellular component biogenesis
 http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization
 http://purl.obolibrary.org/obo/GO_0010185	regulation of cellular defense response	http://purl.obolibrary.org/obo/GO_0006968	cellular defense response
@@ -756,7 +754,6 @@ http://purl.obolibrary.org/obo/GO_0002691	regulation of cellular extravasation	h
 http://purl.obolibrary.org/obo/GO_2001029	regulation of cellular glucuronidation	http://purl.obolibrary.org/obo/GO_0052695	cellular glucuronidation
 http://purl.obolibrary.org/obo/GO_1900069	regulation of cellular hyperosmotic salinity response	http://purl.obolibrary.org/obo/GO_0071475	cellular hyperosmotic salinity response
 http://purl.obolibrary.org/obo/GO_0060341	regulation of cellular localization	http://purl.obolibrary.org/obo/GO_0051641	cellular localization
-http://purl.obolibrary.org/obo/GO_0031323	regulation of cellular metabolic process	http://purl.obolibrary.org/obo/GO_0044237	cellular metabolic process
 http://purl.obolibrary.org/obo/GO_0032847	regulation of cellular pH reduction	http://purl.obolibrary.org/obo/GO_0051452	intracellular pH reduction
 http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process	http://purl.obolibrary.org/obo/GO_0009987	cellular process
 http://purl.obolibrary.org/obo/GO_0043457	regulation of cellular respiration	http://purl.obolibrary.org/obo/GO_0045333	cellular respiration
diff --git a/src/design_patterns/regulation_by.tsv b/src/design_patterns/regulation_by.tsv
index b6186ae213..a47b3e6818 100644
--- a/src/design_patterns/regulation_by.tsv
+++ b/src/design_patterns/regulation_by.tsv
@@ -693,8 +693,6 @@ http://purl.obolibrary.org/obo/GO_2000960	regulation of cellooligosaccharide met
 http://purl.obolibrary.org/obo/GO_2000936	regulation of cellotriose catabolic process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_2000894	cellotriose catabolic process
 http://purl.obolibrary.org/obo/GO_2000933	regulation of cellotriose metabolic process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_2000893	cellotriose metabolic process
 http://purl.obolibrary.org/obo/GO_1900285	regulation of cellotriose transport	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_2001096	cellotriose transport
-http://purl.obolibrary.org/obo/GO_0031326	regulation of cellular biosynthetic process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0044249	cellular biosynthetic process
-http://purl.obolibrary.org/obo/GO_0031329	regulation of cellular catabolic process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0044248	cellular catabolic process
 http://purl.obolibrary.org/obo/GO_0044087	regulation of cellular component biogenesis	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0044085	cellular component biogenesis
 http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization
 http://purl.obolibrary.org/obo/GO_0010185	regulation of cellular defense response	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0006968	cellular defense response
@@ -702,7 +700,6 @@ http://purl.obolibrary.org/obo/GO_0002691	regulation of cellular extravasation	h
 http://purl.obolibrary.org/obo/GO_2001029	regulation of cellular glucuronidation	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0052695	cellular glucuronidation
 http://purl.obolibrary.org/obo/GO_1900069	regulation of cellular hyperosmotic salinity response	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0071475	cellular hyperosmotic salinity response
 http://purl.obolibrary.org/obo/GO_0060341	regulation of cellular localization	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0051641	cellular localization
-http://purl.obolibrary.org/obo/GO_0031323	regulation of cellular metabolic process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0044237	cellular metabolic process
 http://purl.obolibrary.org/obo/GO_0032847	regulation of cellular pH reduction	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0051452	intracellular pH reduction
 http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0009987	cellular process
 http://purl.obolibrary.org/obo/GO_0043457	regulation of cellular respiration	http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0045333	cellular respiration
diff --git a/src/ontology/imports/go-pattern-conformance.ttl b/src/ontology/imports/go-pattern-conformance.ttl
index af0cdea41b..34199f4216 100644
--- a/src/ontology/imports/go-pattern-conformance.ttl
+++ b/src/ontology/imports/go-pattern-conformance.ttl
@@ -13915,36 +13915,6 @@
 <http://purl.obolibrary.org/obo/GO_0031321> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/cc_assembly.yaml> .
 
 
-<http://purl.obolibrary.org/obo/GO_0031323> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> ,
-                                                                                  <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031324> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031325> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031326> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> ,
-                                                                                  <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031327> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031328> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031329> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/regulation.yaml> ,
-                                                                                  <http://purl.obolibrary.org/obo/go/patterns/regulation_by.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031330> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .
-
-
-<http://purl.obolibrary.org/obo/GO_0031331> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/positive_regulation.yaml> .
-
-
 <http://purl.obolibrary.org/obo/GO_0031333> <http://purl.org/dc/terms/conformsTo> <http://purl.obolibrary.org/obo/go/patterns/negative_regulation.yaml> .