diff --git a/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.test.ts b/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.test.ts
new file mode 100644
index 0000000000000..61744b8455435
--- /dev/null
+++ b/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.test.ts
@@ -0,0 +1,61 @@
+/*
+ * Copyright Elasticsearch B.V. and/or licensed to Elasticsearch B.V. under one
+ * or more contributor license agreements. Licensed under the Elastic License
+ * 2.0; you may not use this file except in compliance with the Elastic License
+ * 2.0.
+ */
+
+import { createUserActionServiceMock } from '../../services/mocks';
+import { createMockClient } from '../metrics/test_utils/client';
+import { createCasesClientMockArgs } from '../mocks';
+import { getUsers } from './users';
+import { mockCases } from '../../mocks';
+import type { CaseResolveResponse } from '../../../common/types/api';
+import { getUserProfiles } from '../cases/utils';
+
+jest.mock('../cases/utils');
+
+const getUserProfilesMock = getUserProfiles as jest.Mock;
+
+describe('getUsers', () => {
+  const casesClient = createMockClient();
+
+  casesClient.cases.resolve.mockResolvedValue({
+    case: mockCases[0].attributes,
+  } as CaseResolveResponse);
+
+  const clientArgs = createCasesClientMockArgs();
+  const userActionService = createUserActionServiceMock();
+
+  userActionService.getUsers.mockResolvedValue({
+    participants: [
+      {
+        id: 'foo',
+        owner: 'bar',
+        user: { email: '', full_name: '', username: '', profile_uid: '' },
+      },
+      {
+        id: 'foo',
+        owner: 'bar',
+        user: { email: '', full_name: '', username: '', profile_uid: 'some_profile_id' },
+      },
+    ],
+    assignedAndUnassignedUsers: new Set([]),
+  });
+  getUserProfilesMock.mockResolvedValue(new Map());
+  clientArgs.services.userActionService = userActionService;
+
+  beforeEach(() => {
+    jest.clearAllMocks();
+  });
+
+  it('removes empty uids from getUserProfiles call', async () => {
+    await getUsers({ caseId: 'test-case' }, casesClient, clientArgs);
+
+    expect(getUserProfilesMock).toHaveBeenCalledWith(
+      expect.any(Object),
+      new Set(['some_profile_id']),
+      expect.any(String)
+    );
+  });
+});
diff --git a/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.ts b/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.ts
index cc189f987afe1..834a0bb0edb6b 100644
--- a/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.ts
+++ b/x-pack/platform/plugins/shared/cases/server/client/user_actions/users.ts
@@ -5,7 +5,7 @@
  * 2.0.
  */
 
-import { isString } from 'lodash';
+import { isEmpty, isString } from 'lodash';
 import type { UserProfileAvatarData, UserProfileWithAvatar } from '@kbn/user-profile-components';
 import type { GetCaseUsersResponse } from '../../../common/types/api';
 import { GetCaseUsersResponseRt } from '../../../common/types/api';
@@ -57,12 +57,14 @@ export const getUsers = async (
     const reporter = theCase.case.created_by;
     const reporterProfileIdAsArray = reporter.profile_uid != null ? [reporter.profile_uid] : [];
 
-    const userProfileUids = new Set([
-      ...assignedAndUnassignedUsers,
-      ...participantsUids,
-      ...assigneesUids,
-      ...reporterProfileIdAsArray,
-    ]);
+    const userProfileUids = new Set(
+      [
+        ...assignedAndUnassignedUsers,
+        ...participantsUids,
+        ...assigneesUids,
+        ...reporterProfileIdAsArray,
+      ].filter((uid) => !isEmpty(uid))
+    );
 
     const userProfiles = await getUserProfiles(securityStartPlugin, userProfileUids, 'avatar');