diff --git a/example/README.md b/example/README.md
index dac8f1408..5eae0e383 100644
--- a/example/README.md
+++ b/example/README.md
@@ -52,6 +52,7 @@ The following steps show how to trigger profile scan on device-simple:
 2. Trigger profile scan by sending POST request to DS endpoint: http://edgex-device-simple:59999/api/v3/profilescan with payload:
    ```json
    {
+     "apiVersion": "v3",
      "deviceName": "ProfileScan-Simple-Device",
      "profileName": "ProfileScan-Test-Profile"
    }
diff --git a/internal/application/callback.go b/internal/application/callback.go
index 7b9f9af87..d920627e6 100644
--- a/internal/application/callback.go
+++ b/internal/application/callback.go
@@ -53,6 +53,22 @@ func UpdateProfile(profileRequest requests.DeviceProfileRequest, dic *di.Contain
 	return nil
 }
 
+func DeleteProfile(profileName string, dic *di.Container) errors.EdgeX {
+	lc := bootstrapContainer.LoggingClientFrom(dic.Get)
+	if cache.CheckProfileNotUsed(profileName) {
+		err := cache.Profiles().RemoveByName(profileName)
+		if err != nil {
+			errMsg := fmt.Sprintf("failed to remove device profile %s", profileName)
+			return errors.NewCommonEdgeX(errors.KindServerError, errMsg, err)
+		}
+		lc.Debugf("profile %s is removed from cache", profileName)
+	} else {
+		lc.Warnf("received Profile Deletion System Event for %s, but the profile is still used by some devices", profileName)
+	}
+
+	return nil
+}
+
 func AddDevice(addDeviceRequest requests.AddDeviceRequest, dic *di.Container) errors.EdgeX {
 	device := dtos.ToDeviceModel(addDeviceRequest.Device)
 	lc := bootstrapContainer.LoggingClientFrom(dic.Get)
@@ -174,18 +190,6 @@ func DeleteDevice(name string, dic *di.Container) errors.EdgeX {
 		return errors.NewCommonEdgeX(errors.KindServerError, errMsg, err)
 	}
 
-	// a special case in which user updates the device profile after deleting all
-	// devices in metadata, the profile won't be correctly updated because metadata
-	// does not know which device service callback it needs to call. Remove the unused
-	// device profile in cache so that if it is updated in metadata, next time the
-	// device using it is added/updated, the cache can receive the updated one as well.
-	if device.ProfileName != "" && cache.CheckProfileNotUsed(device.ProfileName) {
-		edgexErr = cache.Profiles().RemoveByName(device.ProfileName)
-		if edgexErr != nil {
-			lc.Warn("failed to remove unused profile", edgexErr.DebugMessages())
-		}
-	}
-
 	return nil
 }
 
diff --git a/internal/controller/messaging/callback.go b/internal/controller/messaging/callback.go
index 4ce686e5f..dbed3dfea 100644
--- a/internal/controller/messaging/callback.go
+++ b/internal/controller/messaging/callback.go
@@ -30,8 +30,11 @@ func MetadataSystemEventsCallback(ctx context.Context, serviceBaseName string, d
 	deviceService := container.DeviceServiceFrom(dic.Get)
 	metadataSystemEventTopic := common.NewPathBuilder().EnableNameFieldEscape(configuration.Service.EnableNameFieldEscape).
 		SetPath(messageBusInfo.GetBaseTopicPrefix()).SetPath(common.MetadataSystemEventSubscribeTopic).SetNameFieldPath(deviceService.Name).SetPath("#").BuildPath()
-
-	lc.Infof("Subscribing to System Events on topic: %s", metadataSystemEventTopic)
+	profileDeleteSystemEventTopic := common.NewPathBuilder().EnableNameFieldEscape(configuration.Service.EnableNameFieldEscape).
+		SetPath(messageBusInfo.GetBaseTopicPrefix()).
+		SetPath(strings.Replace(common.MetadataSystemEventSubscribeTopic, "+/+", common.DeviceProfileSystemEventType+"/"+common.SystemEventActionDelete, 1)).
+		SetPath("#").BuildPath()
+	lc.Infof("Subscribing to System Events on topics: %s and %s", metadataSystemEventTopic, profileDeleteSystemEventTopic)
 
 	messages := make(chan types.MessageEnvelope, 1)
 	messageErrors := make(chan error, 1)
@@ -40,6 +43,10 @@ func MetadataSystemEventsCallback(ctx context.Context, serviceBaseName string, d
 			Topic:    metadataSystemEventTopic,
 			Messages: messages,
 		},
+		{
+			Topic:    profileDeleteSystemEventTopic,
+			Messages: messages,
+		},
 	}
 
 	// Must subscribe to provision watcher System Events separately when the service has an instance name. i.e. -i flag was used.
@@ -85,7 +92,11 @@ func MetadataSystemEventsCallback(ctx context.Context, serviceBaseName string, d
 				}
 
 				serviceName := container.DeviceServiceFrom(dic.Get).Name
-				if systemEvent.Owner != serviceName && systemEvent.Owner != serviceBaseName {
+				if systemEvent.Owner == common.CoreMetaDataServiceKey {
+					if systemEvent.Type != common.DeviceProfileSystemEventType && systemEvent.Action != common.SystemEventActionDelete {
+						lc.Errorf("only support device profile delete system events from owner %s", systemEvent.Owner)
+					}
+				} else if systemEvent.Owner != serviceName && systemEvent.Owner != serviceBaseName {
 					lc.Errorf("unmatched system event owner %s with service name %s", systemEvent.Owner, serviceName)
 					continue
 				}
@@ -155,8 +166,10 @@ func deviceProfileSystemEventAction(systemEvent dtos.SystemEvent, dic *di.Contai
 	switch systemEvent.Action {
 	case common.SystemEventActionUpdate:
 		err = application.UpdateProfile(requests.NewDeviceProfileRequest(deviceProfile), dic)
-	// there is no action needed for Device Profile Add and Delete in Device Service
-	case common.SystemEventActionAdd, common.SystemEventActionDelete:
+	case common.SystemEventActionDelete:
+		err = application.DeleteProfile(deviceProfile.Name, dic)
+	// there is no action needed for Device Profile Add in Device Service
+	case common.SystemEventActionAdd:
 		break
 	default:
 		return fmt.Errorf("unknown %s system event action %s", systemEvent.Type, systemEvent.Action)