diff --git a/src/libraries/System.Memory/ref/System.Memory.cs b/src/libraries/System.Memory/ref/System.Memory.cs
index 53d3da5e0441c2..2aea6f21fe34a1 100644
--- a/src/libraries/System.Memory/ref/System.Memory.cs
+++ b/src/libraries/System.Memory/ref/System.Memory.cs
@@ -277,6 +277,7 @@ public static partial class MemoryExtensions
         public static bool ContainsAnyInRange<T>(this System.ReadOnlySpan<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
         public static bool ContainsAnyInRange<T>(this System.Span<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
+        public static bool ContainsAnyWhiteSpace(this System.ReadOnlySpan<char> span) { throw null; }
         public static void CopyTo<T>(this T[]? source, System.Memory<T> destination) { }
         public static void CopyTo<T>(this T[]? source, System.Span<T> destination) { }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
@@ -331,6 +332,7 @@ public static void CopyTo<T>(this T[]? source, System.Span<T> destination) { }
         public static int IndexOfAnyExceptInRange<T>(this System.ReadOnlySpan<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
         public static int IndexOfAnyExceptInRange<T>(this System.Span<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
+        public static int IndexOfAnyExceptWhiteSpace(this System.ReadOnlySpan<char> span) { throw null; }
         public static int IndexOf<T>(this System.ReadOnlySpan<T> span, System.ReadOnlySpan<T> value) where T : System.IEquatable<T>? { throw null; }
         public static int IndexOf<T>(this System.ReadOnlySpan<T> span, T value) where T : System.IEquatable<T>? { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
@@ -340,6 +342,7 @@ public static void CopyTo<T>(this T[]? source, System.Span<T> destination) { }
         public static int IndexOfAnyInRange<T>(this System.ReadOnlySpan<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
         public static int IndexOfAnyInRange<T>(this System.Span<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
+        public static int IndexOfAnyWhiteSpace(this System.ReadOnlySpan<char> span) { throw null; }
         public static bool IsWhiteSpace(this System.ReadOnlySpan<char> span) { throw null; }
         public static int LastIndexOf(this System.ReadOnlySpan<char> span, System.ReadOnlySpan<char> value, System.StringComparison comparisonType) { throw null; }
         public static int LastIndexOfAny<T>(this System.ReadOnlySpan<T> span, System.Buffers.SearchValues<T> values) where T : System.IEquatable<T>? { throw null; }
@@ -372,6 +375,7 @@ public static void CopyTo<T>(this T[]? source, System.Span<T> destination) { }
         public static int LastIndexOfAnyExceptInRange<T>(this System.ReadOnlySpan<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
         public static int LastIndexOfAnyExceptInRange<T>(this System.Span<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
+        public static int LastIndexOfAnyExceptWhiteSpace(this System.ReadOnlySpan<char> span) { throw null; }
         public static int LastIndexOf<T>(this System.ReadOnlySpan<T> span, System.ReadOnlySpan<T> value) where T : System.IEquatable<T>? { throw null; }
         public static int LastIndexOf<T>(this System.ReadOnlySpan<T> span, T value) where T : System.IEquatable<T>? { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
@@ -381,6 +385,7 @@ public static void CopyTo<T>(this T[]? source, System.Span<T> destination) { }
         public static int LastIndexOfAnyInRange<T>(this System.ReadOnlySpan<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
         public static int LastIndexOfAnyInRange<T>(this System.Span<T> span, T lowInclusive, T highInclusive) where T : System.IComparable<T> { throw null; }
+        public static int LastIndexOfAnyWhiteSpace(this System.ReadOnlySpan<char> span) { throw null; }
         public static bool Overlaps<T>(this System.ReadOnlySpan<T> span, System.ReadOnlySpan<T> other) { throw null; }
         public static bool Overlaps<T>(this System.ReadOnlySpan<T> span, System.ReadOnlySpan<T> other, out int elementOffset) { throw null; }
         [System.Runtime.CompilerServices.OverloadResolutionPriorityAttribute(-1)]
diff --git a/src/libraries/System.Memory/tests/ReadOnlySpan/WhiteSpace.cs b/src/libraries/System.Memory/tests/ReadOnlySpan/WhiteSpace.cs
new file mode 100644
index 00000000000000..09eb02983cf497
--- /dev/null
+++ b/src/libraries/System.Memory/tests/ReadOnlySpan/WhiteSpace.cs
@@ -0,0 +1,261 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+
+using System.Collections.Generic;
+using System.Runtime.InteropServices;
+using Xunit;
+
+namespace System.SpanTests
+{
+    public static partial class ReadOnlySpanTests
+    {
+        [Fact]
+        public static void IsWhiteSpace_True()
+        {
+            Assert.True(Span<char>.Empty.IsWhiteSpace());
+
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            Assert.True(CollectionsMarshal.AsSpan(chars).IsWhiteSpace());
+        }
+
+        [Fact]
+        public static void IsWhiteSpace_False()
+        {
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            var index = chars.Count;
+            chars.AddRange(chars.ToArray());
+            chars.Insert(index, ' ');
+            var span = CollectionsMarshal.AsSpan(chars);
+
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                {
+                    chars[index] = (char)i;
+                    Assert.False(span.IsWhiteSpace());
+                }
+            }
+        }
+
+        [Fact]
+        public static void ContainsAnyWhiteSpace_Found()
+        {
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            var index = chars.Count;
+            chars.AddRange(chars.ToArray());
+            chars.Insert(index, ' ');
+            var span = CollectionsMarshal.AsSpan(chars);
+
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                {
+                    chars[index] = (char)i;
+                    Assert.True(span.ContainsAnyWhiteSpace());
+                }
+            }
+        }
+
+        [Fact]
+        public static void ContainsAnyWhiteSpace_NotFound()
+        {
+            Assert.False(Span<char>.Empty.ContainsAnyWhiteSpace());
+
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            Assert.False(CollectionsMarshal.AsSpan(chars).ContainsAnyWhiteSpace());
+        }
+
+        [Fact]
+        public static void IndexOfAnyWhiteSpace_Found()
+        {
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            var index = chars.Count;
+            chars.AddRange(chars.ToArray());
+            chars.Insert(index, ' ');
+            chars.Insert(index, ' ');
+            var span = CollectionsMarshal.AsSpan(chars);
+
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                {
+                    chars[index] = (char)i;
+                    chars[index + 1] = (char)i;
+                    Assert.Equal(index, span.IndexOfAnyWhiteSpace());
+                }
+            }
+        }
+
+        [Fact]
+        public static void IndexOfAnyWhiteSpace_NotFound()
+        {
+            Assert.Equal(-1, Span<char>.Empty.IndexOfAnyWhiteSpace());
+
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            Assert.Equal(-1, CollectionsMarshal.AsSpan(chars).IndexOfAnyWhiteSpace());
+        }
+
+        [Fact]
+        public static void IndexOfAnyExceptWhiteSpace_Found()
+        {
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            var index = chars.Count;
+            chars.AddRange(chars.ToArray());
+            chars.Insert(index, ' ');
+            chars.Insert(index, ' ');
+            var span = CollectionsMarshal.AsSpan(chars);
+
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                {
+                    chars[index] = (char)i;
+                    chars[index + 1] = (char)i;
+                    Assert.Equal(index, span.IndexOfAnyExceptWhiteSpace());
+                }
+            }
+        }
+
+        [Fact]
+        public static void IndexOfAnyExceptWhiteSpace_NotFound()
+        {
+            Assert.Equal(-1, Span<char>.Empty.IndexOfAnyExceptWhiteSpace());
+
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            Assert.Equal(-1, CollectionsMarshal.AsSpan(chars).IndexOfAnyExceptWhiteSpace());
+        }
+
+        [Fact]
+        public static void LastIndexOfAnyWhiteSpace_Found()
+        {
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            var index = chars.Count;
+            chars.AddRange(chars.ToArray());
+            chars.Insert(index, ' ');
+            chars.Insert(index, ' ');
+            var span = CollectionsMarshal.AsSpan(chars);
+
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                {
+                    chars[index] = (char)i;
+                    chars[index + 1] = (char)i;
+                    Assert.Equal(index + 1, span.LastIndexOfAnyWhiteSpace());
+                }
+            }
+        }
+
+        [Fact]
+        public static void LastIndexOfAnyWhiteSpace_NotFound()
+        {
+            Assert.Equal(-1, Span<char>.Empty.LastIndexOfAnyWhiteSpace());
+
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            Assert.Equal(-1, CollectionsMarshal.AsSpan(chars).LastIndexOfAnyWhiteSpace());
+        }
+
+        [Fact]
+        public static void LastIndexOfAnyExceptWhiteSpace_Found()
+        {
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            var index = chars.Count;
+            chars.AddRange(chars.ToArray());
+            chars.Insert(index, ' ');
+            chars.Insert(index, ' ');
+            var span = CollectionsMarshal.AsSpan(chars);
+
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (!char.IsWhiteSpace((char)i))
+                {
+                    chars[index] = (char)i;
+                    chars[index + 1] = (char)i;
+                    Assert.Equal(index + 1, span.LastIndexOfAnyExceptWhiteSpace());
+                }
+            }
+        }
+
+        [Fact]
+        public static void LastIndexOfAnyExceptWhiteSpace_NotFound()
+        {
+            Assert.Equal(-1, Span<char>.Empty.LastIndexOfAnyExceptWhiteSpace());
+
+            List<char> chars = [];
+            for (int i = 0; i <= char.MaxValue; i++)
+            {
+                if (char.IsWhiteSpace((char)i))
+                    chars.Add((char)i);
+            }
+
+            Assert.Equal(-1, CollectionsMarshal.AsSpan(chars).LastIndexOfAnyExceptWhiteSpace());
+        }
+    }
+}
diff --git a/src/libraries/System.Memory/tests/System.Memory.Tests.csproj b/src/libraries/System.Memory/tests/System.Memory.Tests.csproj
index 38b40b284d1b25..933d3f34d31970 100644
--- a/src/libraries/System.Memory/tests/System.Memory.Tests.csproj
+++ b/src/libraries/System.Memory/tests/System.Memory.Tests.csproj
@@ -193,6 +193,7 @@
     <Compile Include="ReadOnlySpan\ToArray.cs" />
     <Compile Include="ReadOnlySpan\ToString.cs" />
     <Compile Include="ReadOnlySpan\ToUpperLower.cs" />
+    <Compile Include="ReadOnlySpan\WhiteSpace.cs" />
   </ItemGroup>
   <ItemGroup>
     <Compile Include="Memory\AsMemory.cs" />
diff --git a/src/libraries/System.Private.CoreLib/src/System/MemoryExtensions.Globalization.cs b/src/libraries/System.Private.CoreLib/src/System/MemoryExtensions.Globalization.cs
index 5b64d503b836b8..71cd0bcb2e0ee3 100644
--- a/src/libraries/System.Private.CoreLib/src/System/MemoryExtensions.Globalization.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/MemoryExtensions.Globalization.cs
@@ -14,15 +14,9 @@ public static partial class MemoryExtensions
         /// <summary>
         /// Indicates whether the specified span contains only white-space characters.
         /// </summary>
-        public static bool IsWhiteSpace(this ReadOnlySpan<char> span)
-        {
-            for (int i = 0; i < span.Length; i++)
-            {
-                if (!char.IsWhiteSpace(span[i]))
-                    return false;
-            }
-            return true;
-        }
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static bool IsWhiteSpace(this ReadOnlySpan<char> span) =>
+            !string.SearchValuesStorage.WhiteSpaceChars.ContainsAnyExcept(span);
 
         /// <summary>
         /// Returns a value indicating whether the specified <paramref name="value"/> occurs within the <paramref name="span"/>.
@@ -35,6 +29,16 @@ public static bool Contains(this ReadOnlySpan<char> span, ReadOnlySpan<char> val
             return IndexOf(span, value, comparisonType) >= 0;
         }
 
+        /// <summary>
+        /// Returns a value indicating whether the specified span contains <see cref="char.IsWhiteSpace(char)">any
+        /// white-space characters</see>, and returns <see langword="true"/> if found. If not found, returns
+        /// <see langword="false"/>.
+        /// </summary>
+        /// <param name="span">The source span.</param>
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static bool ContainsAnyWhiteSpace(this ReadOnlySpan<char> span) =>
+            string.SearchValuesStorage.WhiteSpaceChars.ContainsAny(span);
+
         /// <summary>
         /// Determines whether this <paramref name="span"/> and the specified <paramref name="other"/> span have the same characters
         /// when compared using the specified <paramref name="comparisonType"/> option.
@@ -149,6 +153,24 @@ public static int IndexOf(this ReadOnlySpan<char> span, ReadOnlySpan<char> value
             }
         }
 
+        /// <summary>
+        /// Reports the zero-based index of the first occurrence of <see cref="char.IsWhiteSpace(char)">any white-space
+        /// characters</see> in the current <paramref name="span"/>, or -1 if not founded.
+        /// </summary>
+        /// <param name="span">The source span.</param>
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static int IndexOfAnyWhiteSpace(this ReadOnlySpan<char> span) =>
+            string.SearchValuesStorage.WhiteSpaceChars.IndexOfAny(span);
+
+        /// <summary>
+        /// Reports the zero-based index of the first occurrence of <see cref="char.IsWhiteSpace(char)">any
+        /// non-white-space characters</see> in the current <paramref name="span"/>, or -1 if not founded.
+        /// </summary>
+        /// <param name="span">The source span.</param>
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static int IndexOfAnyExceptWhiteSpace(this ReadOnlySpan<char> span) =>
+            string.SearchValuesStorage.WhiteSpaceChars.IndexOfAnyExcept(span);
+
         /// <summary>
         /// Reports the zero-based index of the last occurrence of the specified <paramref name="value"/> in the current <paramref name="span"/>.
         /// </summary>
@@ -184,6 +206,24 @@ ref MemoryMarshal.GetReference(value),
             }
         }
 
+        /// <summary>
+        /// Reports the zero-based index of the last occurrence of <see cref="char.IsWhiteSpace(char)">any white-space
+        /// characters</see> in the current <paramref name="span"/>, or -1 if not founded.
+        /// </summary>
+        /// <param name="span">The source span.</param>
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static int LastIndexOfAnyWhiteSpace(this ReadOnlySpan<char> span) =>
+            string.SearchValuesStorage.WhiteSpaceChars.LastIndexOfAny(span);
+
+        /// <summary>
+        /// Reports the zero-based index of the last occurrence of <see cref="char.IsWhiteSpace(char)">any
+        /// non-white-space characters</see> in the current <paramref name="span"/>, or -1 if not founded.
+        /// </summary>
+        /// <param name="span">The source span.</param>
+        [MethodImpl(MethodImplOptions.AggressiveInlining)]
+        public static int LastIndexOfAnyExceptWhiteSpace(this ReadOnlySpan<char> span) =>
+            string.SearchValuesStorage.WhiteSpaceChars.LastIndexOfAnyExcept(span);
+
         /// <summary>
         /// Copies the characters from the source span into the destination, converting each character to lowercase,
         /// using the casing rules of the specified culture.