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Pandas is an open source Python library providing high-performance data structures and data analysis tools. Tkinter is the standard GUI toolkit for python. The pandastable library provides a Tkinter widget to the pandas DataFrame class that can be embedded in a Tkinter application. There is also a standalone application provided called DataExplore that integrates the table and plotting functions in a self-contained application.
There are many ways to work with DataFrame structures such as the IPython Notebook, but for non-programmers requiring an easier to use interface this may be of use.