As Skyscraper was built to be used with RetroPie, the list of supported platforms is largely dictated by their naming scheme and list of platforms. Skyscraper will only rarely add platforms that aren't already on that list.
- 3DO
- Amiga (OCS, ECS, AGA, CD32, CDTV)
- Amstrad CPC
- Apple 2
- Arcade
- AstroCade
- Atari800
- Atari2600
- Atari5200
- Atari7800
- Atari Jaguar
- Atari Jaguar CD
- Atari Lynx
- Atari ST
- AtomisWave
- Coco (Tandy Colour Computer)
- ColecoVision
- Commodore 16/64/128
- Commodore Vic-20
- Daphne
- Dragon 32/64
- Dreamcast
- EasyRPG (RPG Maker 2000/2003 games)
- Emerson Arcadia 2001
- Fairchild Channel F
- Famicom Disk System
- FB Neo (formerly FB Alpha)
- Game Boy
- Game Boy Advance
- Game Boy Color
- GameCube
- Game & Watch
- Intellivision
- Mame
- Megadrive / Genesis
- MSX (MSX, MSX 2, MSX 2+, MSX Laserdisc)
- Naomi
- NeoGeo
- NeoGeo CD
- NeoGeo Pocket
- NeoGeo Pocket Color
- Nintendo 64
- Nintendo DS
- Nintendo Entertainment System
- Nintendo Switch
- Oric (Oric-1, Oric Atmos)
- PC
- PC-8800
- PC-9800
- PC-Engine / TurboGrafx-16
- PC-Engine CD / TurboGrafx-16 CD
- PC-FX
- Pico-8 (Virtual console)
- Playstation
- Playstation 2
- Playstation Portable
- Pokémon Mini
- Ports (For games ported to RaspBerry Pi)
- ScummVM (looks for PC or Amiga matches)
- Sega 32x
- Sega CD
- Sega Game Gear
- Sega Master System
- Sega Saturn
- Sega SG-1000
- Sharp X1
- Sharp X68000
- Steam (through Moonlight streaming)
- Super Nintendo
- TI-99/4A
- Thomson MO/TO
- TRS-80
- Vectrex
- Videopac (Oddysey 2)
- Virtual Boy
- Wii
- Wii U
- WonderSwan
- WonderSwan Color
- Z-Machine
- ZX81
- ZX Spectrum