diff --git a/library/src/main/kotlin/build/buf/connect/BidirectionalStreamInterface.kt b/library/src/main/kotlin/build/buf/connect/BidirectionalStreamInterface.kt
index 319eb8e9..0e7800ed 100644
--- a/library/src/main/kotlin/build/buf/connect/BidirectionalStreamInterface.kt
+++ b/library/src/main/kotlin/build/buf/connect/BidirectionalStreamInterface.kt
@@ -42,10 +42,36 @@ interface BidirectionalStreamInterface<Input, Output> {
     fun close()
 
     /**
-     * Determine if the underlying stream is closed.
+     * Determine if the underlying send and receive stream is closed.
      *
-     * @return true if the underlying stream is closed. If the stream is still open,
+     * @return true if the underlying send and receive stream is closed. If the stream is still open,
      *         this will return false.
      */
     fun isClosed(): Boolean
+
+    /**
+     * Close the send stream. No calls to [send] are valid after calling [sendClose].
+     */
+    fun sendClose()
+
+    /**
+     * Close the receive stream.
+     */
+    fun receiveClose()
+
+    /**
+     * Determine if the underlying client send stream is closed.
+     *
+     * @return true if the underlying client receive stream is closed. If the stream is still open,
+     *         this will return false.
+     */
+    fun isSendClosed(): Boolean
+
+    /**
+     * Determine if the underlying client receive stream is closed.
+     *
+     * @return true if the underlying client receive stream is closed. If the stream is still open,
+     *         this will return false.
+     */
+    fun isReceiveClosed(): Boolean
 }
diff --git a/library/src/main/kotlin/build/buf/connect/ClientOnlyStreamInterface.kt b/library/src/main/kotlin/build/buf/connect/ClientOnlyStreamInterface.kt
index 4513b786..9e0010f1 100644
--- a/library/src/main/kotlin/build/buf/connect/ClientOnlyStreamInterface.kt
+++ b/library/src/main/kotlin/build/buf/connect/ClientOnlyStreamInterface.kt
@@ -26,6 +26,13 @@ interface ClientOnlyStreamInterface<Input, Output> {
      */
     suspend fun send(input: Input): Result<Unit>
 
+    /**
+     * Receive a single response and close the stream.
+     *
+     * @return the single response [StreamResult].
+     */
+    suspend fun receiveAndClose(): StreamResult<Output>
+
     /**
      * Close the stream. No calls to [send] are valid after calling [close].
      */
diff --git a/library/src/main/kotlin/build/buf/connect/ServerOnlyStreamInterface.kt b/library/src/main/kotlin/build/buf/connect/ServerOnlyStreamInterface.kt
index be612bf9..ddd664c1 100644
--- a/library/src/main/kotlin/build/buf/connect/ServerOnlyStreamInterface.kt
+++ b/library/src/main/kotlin/build/buf/connect/ServerOnlyStreamInterface.kt
@@ -38,6 +38,17 @@ interface ServerOnlyStreamInterface<Input, Output> {
      */
     suspend fun send(input: Input): Result<Unit>
 
+    /**
+     * Send a request to the server over the stream and closes the request.
+     *
+     * Can only be called exactly one time when starting the stream.
+     *
+     * @param input The request message to send.
+     * @return [Result.success] on send success, [Result.failure] on
+     *         any sends which are not successful.
+     */
+    suspend fun sendAndClose(input: Input): Result<Unit>
+
     /**
      * Close the stream. No calls to [send] are valid after calling [close].
      */
diff --git a/library/src/main/kotlin/build/buf/connect/http/HTTPClientInterface.kt b/library/src/main/kotlin/build/buf/connect/http/HTTPClientInterface.kt
index 796b1f44..9e3d8df4 100644
--- a/library/src/main/kotlin/build/buf/connect/http/HTTPClientInterface.kt
+++ b/library/src/main/kotlin/build/buf/connect/http/HTTPClientInterface.kt
@@ -49,9 +49,11 @@ interface HTTPClientInterface {
 
 class Stream(
     private val onSend: (Buffer) -> Unit,
-    private val onClose: () -> Unit
+    private val onSendClose: () -> Unit = {},
+    private val onReceiveClose: () -> Unit = {}
 ) {
-    private val isClosed = AtomicReference(false)
+    private val isSendClosed = AtomicReference(false)
+    private val isReceiveClosed = AtomicReference(false)
 
     fun send(buffer: Buffer): Result<Unit> {
         if (isClosed()) {
@@ -65,13 +67,27 @@ class Stream(
         }
     }
 
-    fun close() {
-        if (!isClosed.getAndSet(true)) {
-            onClose()
+    fun sendClose() {
+        if (!isSendClosed.getAndSet(true)) {
+            onSendClose()
+        }
+    }
+
+    fun receiveClose() {
+        if (!isReceiveClosed.getAndSet(true)) {
+            onReceiveClose()
         }
     }
 
     fun isClosed(): Boolean {
-        return isClosed.get()
+        return isSendClosed() && isReceiveClosed()
+    }
+
+    fun isSendClosed(): Boolean {
+        return isSendClosed.get()
+    }
+
+    fun isReceiveClosed(): Boolean {
+        return isReceiveClosed.get()
     }
 }
diff --git a/library/src/main/kotlin/build/buf/connect/impl/BidirectionalStream.kt b/library/src/main/kotlin/build/buf/connect/impl/BidirectionalStream.kt
index e452e11c..f60841c5 100644
--- a/library/src/main/kotlin/build/buf/connect/impl/BidirectionalStream.kt
+++ b/library/src/main/kotlin/build/buf/connect/impl/BidirectionalStream.kt
@@ -45,10 +45,26 @@ internal class BidirectionalStream<Input, Output>(
     }
 
     override fun close() {
-        stream.close()
+        stream.sendClose()
     }
 
     override fun isClosed(): Boolean {
         return stream.isClosed()
     }
+
+    override fun sendClose() {
+        stream.sendClose()
+    }
+
+    override fun receiveClose() {
+        stream.receiveClose()
+    }
+
+    override fun isSendClosed(): Boolean {
+        return stream.isSendClosed()
+    }
+
+    override fun isReceiveClosed(): Boolean {
+        return stream.isReceiveClosed()
+    }
 }
diff --git a/library/src/main/kotlin/build/buf/connect/impl/ClientOnlyStream.kt b/library/src/main/kotlin/build/buf/connect/impl/ClientOnlyStream.kt
index 9e683c97..22489645 100644
--- a/library/src/main/kotlin/build/buf/connect/impl/ClientOnlyStream.kt
+++ b/library/src/main/kotlin/build/buf/connect/impl/ClientOnlyStream.kt
@@ -16,6 +16,7 @@ package build.buf.connect.impl
 
 import build.buf.connect.BidirectionalStreamInterface
 import build.buf.connect.ClientOnlyStreamInterface
+import build.buf.connect.StreamResult
 
 /**
  * Concrete implementation of [ClientOnlyStreamInterface].
@@ -27,6 +28,15 @@ internal class ClientOnlyStream<Input, Output>(
         return messageStream.send(input)
     }
 
+    override suspend fun receiveAndClose(): StreamResult<Output> {
+        val resultChannel = messageStream.resultChannel()
+        try {
+            return resultChannel.receive()
+        } finally {
+            resultChannel.cancel()
+        }
+    }
+
     override fun close() {
         messageStream.close()
     }
diff --git a/library/src/main/kotlin/build/buf/connect/impl/ProtocolClient.kt b/library/src/main/kotlin/build/buf/connect/impl/ProtocolClient.kt
index de857d7e..fd66e091 100644
--- a/library/src/main/kotlin/build/buf/connect/impl/ProtocolClient.kt
+++ b/library/src/main/kotlin/build/buf/connect/impl/ProtocolClient.kt
@@ -192,18 +192,27 @@ class ProtocolClient(
             channel.send(result)
         }
         continuation.invokeOnCancellation {
-            httpStream.close()
+            httpStream.sendClose()
+            httpStream.receiveClose()
+        }
+        val stream = Stream(
+            onSend = { buffer ->
+                httpStream.send(streamFunc.requestBodyFunction(buffer))
+            },
+            onReceiveClose = {
+                httpStream.receiveClose()
+            },
+            onSendClose = {
+                httpStream.sendClose()
+            }
+        )
+        channel.invokeOnClose {
+            // Receive channel is closed so the stream's receive will be closed.
+            stream.receiveClose()
         }
         continuation.resume(
             BidirectionalStream(
-                Stream(
-                    onSend = { buffer ->
-                        httpStream.send(streamFunc.requestBodyFunction(buffer))
-                    },
-                    onClose = {
-                        httpStream.close()
-                    }
-                ),
+                stream,
                 requestCodec,
                 channel
             )
diff --git a/library/src/main/kotlin/build/buf/connect/impl/ServerOnlyStream.kt b/library/src/main/kotlin/build/buf/connect/impl/ServerOnlyStream.kt
index 92538ff4..4199d0e8 100644
--- a/library/src/main/kotlin/build/buf/connect/impl/ServerOnlyStream.kt
+++ b/library/src/main/kotlin/build/buf/connect/impl/ServerOnlyStream.kt
@@ -29,6 +29,14 @@ internal class ServerOnlyStream<Input, Output>(
         return messageStream.resultChannel()
     }
 
+    override suspend fun sendAndClose(input: Input): Result<Unit> {
+        return try {
+            messageStream.send(input)
+        } finally {
+            messageStream.close()
+        }
+    }
+
     override suspend fun send(input: Input): Result<Unit> {
         return messageStream.send(input)
     }
diff --git a/okhttp/src/main/kotlin/build/buf/connect/okhttp/OkHttpStream.kt b/okhttp/src/main/kotlin/build/buf/connect/okhttp/OkHttpStream.kt
index 08eb8b62..b786d7b1 100644
--- a/okhttp/src/main/kotlin/build/buf/connect/okhttp/OkHttpStream.kt
+++ b/okhttp/src/main/kotlin/build/buf/connect/okhttp/OkHttpStream.kt
@@ -48,7 +48,8 @@ internal fun OkHttpClient.initializeStream(
     request: HTTPRequest,
     onResult: suspend (StreamResult<Buffer>) -> Unit
 ): Stream {
-    val isClosed = AtomicBoolean(false)
+    val isSendClosed = AtomicBoolean(false)
+    val isReceiveClosed = AtomicBoolean(false)
     val duplexRequestBody = PipeDuplexRequestBody(request.contentType.toMediaType())
     val builder = Request.Builder()
         .url(request.url)
@@ -60,23 +61,21 @@ internal fun OkHttpClient.initializeStream(
     }
     val callRequest = builder.build()
     val call = newCall(callRequest)
-    call.enqueue(ResponseCallback(onResult, isClosed))
+    call.enqueue(ResponseCallback(onResult, isSendClosed))
     return Stream(
         onSend = { buffer ->
-            if (!isClosed.get()) {
+            if (!isSendClosed.get()) {
                 duplexRequestBody.forConsume(buffer)
             }
         },
-        onClose = {
-            try {
-                isClosed.set(true)
-                call.cancel()
-                duplexRequestBody.close()
-            } catch (_: Throwable) {
-                // No-op
-            }
+        onSendClose = {
+            isSendClosed.set(true)
+            duplexRequestBody.close()
         }
-    )
+    ) {
+        isReceiveClosed.set(true)
+        call.cancel()
+    }
 }
 
 private class ResponseCallback(