diff --git a/backend/cellguide/pipeline/__init__.py b/backend/cellguide/pipeline/__init__.py
index b07a960e2126e..f768b0355a897 100644
--- a/backend/cellguide/pipeline/__init__.py
+++ b/backend/cellguide/pipeline/__init__.py
@@ -17,6 +17,12 @@
 from backend.cellguide.pipeline.ontology_tree import run as run_ontology_tree_pipeline
 from backend.cellguide.pipeline.source_collections import run as run_source_collections_pipeline
 from backend.common.utils.cloudfront import create_invalidation_for_cellguide_data
+from backend.common.utils.result_notification import (
+    format_failed_batch_issue_slack_alert,
+    gen_cg_pipeline_failure_message,
+    gen_cg_pipeline_success_message,
+    notify_slack,
+)
 
 logger = logging.getLogger(__name__)
 
@@ -55,8 +61,8 @@ def run_cellguide_pipeline():
         gpt_seo_output_directory=GPT_SEO_OUTPUT_DIRECTORY_FOLDERNAME,
     )
 
-    upload_cellguide_pipeline_output_to_s3(output_directory=output_directory)
-    upload_gpt_descriptions_to_s3(
+    output_path = upload_cellguide_pipeline_output_to_s3(output_directory=output_directory)
+    description_output_path = upload_gpt_descriptions_to_s3(
         gpt_output_directory=GPT_OUTPUT_DIRECTORY_FOLDERNAME,
         gpt_seo_output_directory=GPT_SEO_OUTPUT_DIRECTORY_FOLDERNAME,
     )
@@ -67,6 +73,8 @@ def run_cellguide_pipeline():
     # cleanup
     cleanup(output_directory=output_directory)
 
+    return output_path, description_output_path
+
 
 def upload_cellguide_pipeline_output_to_s3(*, output_directory: str):
     """
@@ -97,6 +105,10 @@ def upload_cellguide_pipeline_output_to_s3(*, output_directory: str):
     # this is used for custom cloudfront error handling
     s3_provider.upload_file("404", bucket, "404", {})
 
+    output_path = f"{bucket_path}{output_directory}"
+
+    return output_path
+
 
 def upload_gpt_descriptions_to_s3(*, gpt_output_directory: str, gpt_seo_output_directory: str) -> None:
     bucket_path = get_bucket_path()
@@ -113,6 +125,10 @@ def upload_gpt_descriptions_to_s3(*, gpt_output_directory: str, gpt_seo_output_d
         num_descriptions = len(glob(f"{src_directory}/*.json"))
         logger.info(f"Uploaded {num_descriptions} GPT descriptions to {bucket_path}{dst_directory}/")
 
+    description_output_path = f"{bucket_path}{dst_directory}/"
+
+    return description_output_path
+
 
 def cleanup(*, output_directory: str):
     logger.info(f"Cleaning up {output_directory} and other CellGuide pipeline outputs")
@@ -129,5 +145,14 @@ def cleanup(*, output_directory: str):
 
 
 if __name__ == "__main__":
-    run_cellguide_pipeline()
+    try:
+        output_path, description_output_path = run_cellguide_pipeline()
+        success_message = gen_cg_pipeline_success_message(output_path, description_output_path)
+        notify_slack(success_message)
+    except Exception as e:
+        logger.exception("Cell Guide Pipeline failed")
+        failure_message = format_failed_batch_issue_slack_alert(
+            gen_cg_pipeline_failure_message(f"Issue with Cell Guide pipeline run: {e}. See logs for more detail.")
+        )
+        notify_slack(failure_message)
     sys.exit()
diff --git a/backend/common/providers/crossref_provider.py b/backend/common/providers/crossref_provider.py
index 79c356729290c..7b996d93d9359 100644
--- a/backend/common/providers/crossref_provider.py
+++ b/backend/common/providers/crossref_provider.py
@@ -75,7 +75,8 @@ def _fetch_crossref_payload(self, doi):
             res.raise_for_status()
         except requests.RequestException as e:
             if e.response is not None and e.response.status_code == 404:
-                raise CrossrefDOINotFoundException from e
+                logging.warning(f"DOI {doi} not found, skipping.")
+                return None
             else:
                 raise CrossrefFetchException("Cannot fetch metadata from Crossref") from e
 
diff --git a/backend/common/utils/result_notification.py b/backend/common/utils/result_notification.py
index 3ca3d5c4bf3b1..c690be06a7d7a 100644
--- a/backend/common/utils/result_notification.py
+++ b/backend/common/utils/result_notification.py
@@ -106,3 +106,48 @@ def gen_wmg_pipeline_success_message(snapshot_path: str, dataset_count: int, cel
             },
         ]
     }
+
+
+def gen_cg_pipeline_success_message(output_path: str, description_output_path: str) -> dict:
+    return {
+        "blocks": [
+            {
+                "type": "header",
+                "text": {
+                    "type": "plain_text",
+                    "text": "CellGuide Pipeline Run Succeeded:tada: ",
+                    "emoji": True,
+                },
+            },
+            {
+                "type": "section",
+                "text": {
+                    "type": "mrkdwn",
+                    "text": f"\n* CellGuide snapshot stored in {output_path}"
+                    f"\n* GPT Descriptions can be found in {description_output_path}.",
+                },
+            },
+        ]
+    }
+
+
+def gen_cg_pipeline_failure_message(failure_info: str) -> dict:
+    return {
+        "blocks": [
+            {
+                "type": "header",
+                "text": {
+                    "type": "plain_text",
+                    "text": "CellGuide Pipeline Run FAILED:alert:",
+                    "emoji": True,
+                },
+            },
+            {
+                "type": "section",
+                "text": {
+                    "type": "mrkdwn",
+                    "text": f"CellGuide Pipeline failure @sc-oncall-eng \n{failure_info}",
+                },
+            },
+        ]
+    }
diff --git a/tests/unit/backend/common/test_crossref_provider.py b/tests/unit/backend/common/test_crossref_provider.py
index 20506dca8a111..980a966f03a2e 100644
--- a/tests/unit/backend/common/test_crossref_provider.py
+++ b/tests/unit/backend/common/test_crossref_provider.py
@@ -7,7 +7,6 @@
 from requests.models import HTTPError, Response
 
 from backend.common.providers.crossref_provider import (
-    CrossrefDOINotFoundException,
     CrossrefException,
     CrossrefFetchException,
     CrossrefParseException,
@@ -305,9 +304,9 @@ def test__provider_throws_exception_if_request_fails(self, mock_config, mock_get
 
     @patch("backend.common.providers.crossref_provider.requests.get")
     @patch("backend.common.providers.crossref_provider.CorporaConfig")
-    def test__provider_throws_exception_if_request_fails_with_404(self, mock_config, mock_get):
+    def test__provider_returns_none_on_404(self, mock_config, mock_get):
         """
-        Asserts a CrossrefFetchException if the GET request fails for any reason
+        Asserts that the function returns (None, None, None) if the GET request fails with a 404 status.
         """
         response_404 = Response()
         response_404.status_code = 404
@@ -315,8 +314,9 @@ def test__provider_throws_exception_if_request_fails_with_404(self, mock_config,
 
         provider = CrossrefProvider()
 
-        with self.assertRaises(CrossrefDOINotFoundException):
-            provider.fetch_metadata("test_doi")
+        result = provider.fetch_metadata("test_doi")
+
+        self.assertEqual(result, (None, None, None), "Expected None for a 404 response")
 
     @patch("backend.common.providers.crossref_provider.requests.get")
     @patch("backend.common.providers.crossref_provider.CorporaConfig")