diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index c487b0a17a288d..a36773a8e16d66 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -2,6 +2,8 @@
 
 ## Unreleased
 
+-   `ComboboxControl`: Add an `isLoading` prop to show a loading spinner ([#68990](https://github.com/WordPress/gutenberg/pull/68990))
+
 ## 29.3.0 (2025-01-29)
 
 ### Enhancements
diff --git a/packages/components/src/combobox-control/README.md b/packages/components/src/combobox-control/README.md
index 4089cf9c56e9b5..7a11c8b95fe2e9 100644
--- a/packages/components/src/combobox-control/README.md
+++ b/packages/components/src/combobox-control/README.md
@@ -39,6 +39,7 @@ function MyComboboxControl() {
 			label="Font Size"
 			value={ fontSize }
 			onChange={ setFontSize }
+			isLoading={ isLoading }
 			options={ filteredOptions }
 			onFilterValueChange={ ( inputValue ) =>
 				setFilteredOptions(
@@ -112,13 +113,20 @@ If the control is clicked, the dropdown will expand regardless of this prop.
 -   Required: No
 -   Default: `true`
 
-### placeholder
+#### placeholder
 
 If passed, the combobox input will show a placeholder string if no values are present.
 
 -   Type: `string`
 -   Required: No
 
+#### isLoading
+
+Show a spinner (and hide the suggestions dropdown) while data about the matching suggestions (ie the `options` prop) is loading
+
+-   Type: `Boolean`
+-   Required: No
+
 #### __experimentalRenderItem
 
 Custom renderer invoked for each option in the suggestion list. The render prop receives as its argument an object containing, under the `item` key, the single option's data (directly from the array of data passed to the `options` prop).
diff --git a/packages/components/src/combobox-control/index.tsx b/packages/components/src/combobox-control/index.tsx
index 28510c8653d02e..9c6bd2a4d75dd2 100644
--- a/packages/components/src/combobox-control/index.tsx
+++ b/packages/components/src/combobox-control/index.tsx
@@ -35,6 +35,7 @@ import type { TokenInputProps } from '../form-token-field/types';
 import { useDeprecated36pxDefaultSizeProp } from '../utils/use-deprecated-props';
 import { withIgnoreIMEEvents } from '../utils/with-ignore-ime-events';
 import { maybeWarnDeprecated36pxSize } from '../utils/deprecated-36px-size';
+import Spinner from '../spinner';
 
 const noop = () => {};
 
@@ -126,6 +127,7 @@ function ComboboxControl( props: ComboboxControlProps ) {
 		help,
 		allowReset = true,
 		className,
+		isLoading = false,
 		messages = {
 			selected: __( 'Item selected.' ),
 		},
@@ -362,6 +364,7 @@ function ComboboxControl( props: ComboboxControlProps ) {
 								onChange={ onInputChange }
 							/>
 						</FlexBlock>
+						{ isLoading && <Spinner /> }
 						{ allowReset && (
 							<Button
 								size="small"
@@ -375,7 +378,7 @@ function ComboboxControl( props: ComboboxControlProps ) {
 							/>
 						) }
 					</InputWrapperFlex>
-					{ isExpanded && (
+					{ isExpanded && ! isLoading && (
 						<SuggestionsList
 							instanceId={ instanceId }
 							// The empty string for `value` here is not actually used, but is
diff --git a/packages/components/src/combobox-control/style.scss b/packages/components/src/combobox-control/style.scss
index c8fd8a168c0fb7..558475f6bd522e 100644
--- a/packages/components/src/combobox-control/style.scss
+++ b/packages/components/src/combobox-control/style.scss
@@ -36,5 +36,8 @@ input.components-combobox-control__input[type="text"] {
 	&:focus-within {
 		@include input-style__focus();
 	}
-}
 
+	.components-spinner {
+		margin: 0;
+	}
+}
diff --git a/packages/components/src/combobox-control/types.ts b/packages/components/src/combobox-control/types.ts
index 470b38c35e2c8a..3398e9ee9a760e 100644
--- a/packages/components/src/combobox-control/types.ts
+++ b/packages/components/src/combobox-control/types.ts
@@ -86,4 +86,11 @@ export type ComboboxControlProps = Pick<
 	 * If passed, the combobox input will show a placeholder string if no values are present.
 	 */
 	placeholder?: string;
+	/**
+	 * Show a spinner (and hide the suggestions dropdown) while data
+	 * about the matching suggestions (ie the `options` prop) is loading
+	 *
+	 * @default false
+	 */
+	isLoading?: boolean;
 };