diff --git a/browser/src/ConstraintTable/ConstraintTable.tsx b/browser/src/ConstraintTable/ConstraintTable.tsx index 87f18865e..5e3202158 100644 --- a/browser/src/ConstraintTable/ConstraintTable.tsx +++ b/browser/src/ConstraintTable/ConstraintTable.tsx @@ -68,7 +68,12 @@ const ConstraintTable = ({ datasetId, geneOrTranscript }: Props) => { if (geneOrTranscript.chrom === 'M') { if (isGene(geneOrTranscript)) { - return + return ( + + ) } return

Constraint is not available for mitochondrial transcripts

} diff --git a/browser/src/ConstraintTable/MitochondrialConstraintTable.tsx b/browser/src/ConstraintTable/MitochondrialConstraintTable.tsx index 15412a10e..cfe090faa 100644 --- a/browser/src/ConstraintTable/MitochondrialConstraintTable.tsx +++ b/browser/src/ConstraintTable/MitochondrialConstraintTable.tsx @@ -3,8 +3,10 @@ import { MitochondrialGeneConstraint, ProteinMitochondrialGeneConstraint, RNAMitochondrialGeneConstraint, + GeneTranscript, } from '../GenePage/GenePage' import { BaseTable, TooltipAnchor } from '@gnomad/ui' +import Link from '../Link' import { ConstraintHighlight } from './constraintMetrics' const isProteinMitochondrialGeneConstraint = ( @@ -138,45 +140,57 @@ const RNAConstraintMetrics = ({ constraint }: { constraint: RNAMitochondrialGene const MitochondrialConstraintTable = ({ constraint, + transcript, }: { constraint: MitochondrialGeneConstraint | null + transcript: GeneTranscript | null }) => { if (constraint === null) { return

Constraint is not available on this gene

} return ( - // @ts-expect-error - - - - Category - - {' '} - <> - {/* @ts-expect-error */} - - Expected - - - - - <> - {/* @ts-expect-error */} - - Observed - - - - Constraint metrics - - {' '} - {isProteinMitochondrialGeneConstraint(constraint) ? ( - - ) : ( - + <> + {/* @ts-expect-error */} + + + + Category + + {' '} + <> + {/* @ts-expect-error */} + + Expected + + + + + <> + {/* @ts-expect-error */} + + Observed + + + + Constraint metrics + + + {isProteinMitochondrialGeneConstraint(constraint) ? ( + + ) : ( + + )} + + {transcript !== null && ( + <> + Constraint metrics based on transcript{' '} + + {transcript.transcript_id}.{transcript.transcript_version} + + )} - + ) } diff --git a/browser/src/ConstraintTable/__snapshots__/ConstraintTable.spec.tsx.snap b/browser/src/ConstraintTable/__snapshots__/ConstraintTable.spec.tsx.snap index e3b24031b..fa4f87948 100644 --- a/browser/src/ConstraintTable/__snapshots__/ConstraintTable.spec.tsx.snap +++ b/browser/src/ConstraintTable/__snapshots__/ConstraintTable.spec.tsx.snap @@ -141,420 +141,468 @@ exports[`ConstraintTable with "exac" dataset selected with a minimal transcript `; exports[`ConstraintTable with "exac" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "exac" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + - 0.27 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "exac" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
-`; - -exports[`ConstraintTable with "exac" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + - + - - - - - - - - - - - - - - - - - - - - - - + + + + - -
- Category - - - + Expected + + - Expected - - - + Observed + + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - +
- 0.06 - - ) - -
-`; - -exports[`ConstraintTable with "exac" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` -

- Constraint is not available for mitochondrial transcripts -

+ Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; -exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected and gene with available constraint has no unexpected changes 1`] = ` +exports[`ConstraintTable with "exac" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` [ -
- - - - - - + + + - + - - - - + Observed + + + + + + + + + + + + + + + + + + + + + + + + + +
- Category - - - Expected SNVs - - +
+ Category + + + - - Observed SNVs - - + + - Constraint metrics - -
+ Constraint metrics +
+ Synonymous + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
+ Missense + + 0.34 + + 0.33 + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) +
+ pLoF + + 0.12 + + 0.11 + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) +
, + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] +`; + +exports[`ConstraintTable with "exac" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` +

+ Constraint is not available for mitochondrial transcripts +

+`; + +exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected and gene with available constraint has no unexpected changes 1`] = ` +[ +
+ + + + + + + + + + + + + + + + + + + + + + + +
+ Category + + + Expected SNVs + + + + Observed SNVs + + + Constraint metrics + +
@@ -1284,367 +1332,415 @@ exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected with a minimal tr `; exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + 		+ + Observed + + + Constraint metrics +
+ RNA variant + + 22.2 + + 1.10 + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) +
, + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + - 0.27 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + - 0.06 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_cnv_r4" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -2427,367 +2523,415 @@ exports[`ConstraintTable with "gnomad_r2_1" dataset selected with a minimal tran `; exports[`ConstraintTable with "gnomad_r2_1" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - - + + - - - - - - - - - - - -
- Category - - - - Expected - - - +
- Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + - 0.27 - - ) - -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + - 0.06 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -3578,367 +3722,415 @@ exports[`ConstraintTable with "gnomad_r2_1_controls" dataset selected with a min `; exports[`ConstraintTable with "gnomad_r2_1_controls" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_controls" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - - + + - - - - - - - - - - - -
- Category - - - - Expected - - - +
- Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + - 0.27 - - ) - -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_controls" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_controls" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + + + Observed + + + Constraint metrics +
+ Synonymous + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
+ Missense + + 0.34 + + 0.33 + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) +
- 0.06 - - ) - -
+ pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_controls" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -4729,367 +4921,415 @@ exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a m `; exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - + + + + + + + + + + + +
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + + + Observed + + + Constraint metrics +
+ RNA variant + + 22.2 + + 1.10 + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) +
, + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] +`; + +exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` +[ + + + + + + + - -
+ Category + + + + Expected + + + + Observed + + - 0.27 - - ) - -
-`; - -exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + + + - + + + + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + + + Observed + + + Constraint metrics +
+ Synonymous + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- 0.06 - - ) - -
+ Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_cancer" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -5880,367 +6120,415 @@ exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mi `; exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - + + + + + + + + + + + + +
- Category - - - +
- Expected - - - + + + + Expected + + + + Observed + + + Constraint metrics +
+ RNA variant + + 22.2 + + 1.10 + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) +
, + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] +`; + +exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` +[ + + + + + + + - - - - - - - - - - + + + + - -
+ Category + + + + Expected + + + + Observed + + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - +
- 0.27 - - ) - -
-`; - -exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + + + + - + + + + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- Expected - - - + + 0.34 + + 0.33 + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - + + + + + + - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + + + Observed + + + Constraint metrics +
- 0.06 - - ) - -
+ Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_neuro" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -7031,367 +7319,415 @@ exports[`ConstraintTable with "gnomad_r2_1_non_topmed" dataset selected with a m `; exports[`ConstraintTable with "gnomad_r2_1_non_topmed" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_topmed" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + - 0.27 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_topmed" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_topmed" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - + - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + + + Observed + + - 0.06 - - ) - -
+ Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r2_1_non_topmed" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -8606,367 +8942,415 @@ exports[`ConstraintTable with "gnomad_r4" dataset selected with a minimal transc `; exports[`ConstraintTable with "gnomad_r4" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + - 0.27 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + - 0.06 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -9749,367 +10133,415 @@ exports[`ConstraintTable with "gnomad_r4_non_ukb" dataset selected with a minima `; exports[`ConstraintTable with "gnomad_r4_non_ukb" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4_non_ukb" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - + + + + + + - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + + + Observed + + + Constraint metrics +
- 0.27 - - ) - -
+ RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4_non_ukb" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4_non_ukb" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + + - -
- Category - - - +
- Expected - - - + + + + Expected + + + + Observed + + + Constraint metrics +
+ Synonymous + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + + 0.34 + + 0.33 + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) +
- 0.06 - - ) - -
+ pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_r4_non_ukb" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -10892,367 +11324,415 @@ exports[`ConstraintTable with "gnomad_sv_r2_1" dataset selected with a minimal t `; exports[`ConstraintTable with "gnomad_sv_r2_1" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - + - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + + + Observed + + - 0.27 - - ) - -
+ Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - + + + + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + + - -
- Category - - - +
- Expected - - - + + + + Expected + + + + Observed + + + Constraint metrics +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- 0.06 - - ) - -
+ Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -12043,367 +12523,415 @@ exports[`ConstraintTable with "gnomad_sv_r2_1_controls" dataset selected with a `; exports[`ConstraintTable with "gnomad_sv_r2_1_controls" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_controls" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - + Expected + + + - 0.27 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_controls" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_controls" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + + + + + + + + + - + + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + + - -
- Category - - - +
+ Category + + + + Expected + + + + Observed + + + Constraint metrics +
- Expected - - - + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + + 0.34 + + 0.33 + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) +
- 0.06 - - ) - -
+ pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_controls" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -13194,367 +13722,415 @@ exports[`ConstraintTable with "gnomad_sv_r2_1_non_neuro" dataset selected with a `; exports[`ConstraintTable with "gnomad_sv_r2_1_non_neuro" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_non_neuro" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + + - + + - - - - - - - - - - + + + + - -
- Category - - - +
- Expected - - - + + + + Expected + + + + Observed + + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - +
- 0.27 - - ) - -
+ RNA variant + + + 22.2 + + + 1.10 + + + o/e = + 0.33 + ( + 0.31 + - + + 0.27 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_non_neuro" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ + + Expected + + + + + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_non_neuro" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + + + + - + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + + - -
- Category - - - +
+ Category + + + + Expected + + + + Observed + + - Expected - - - +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- 0.06 - - ) - -
+ Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r2_1_non_neuro" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = ` @@ -14272,432 +14848,480 @@ exports[`ConstraintTable with "gnomad_sv_r4" dataset selected and transcript wit - + + 0 + + + + + + 1 + + + + + + +
+`; + +exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a minimal gene has no unexpected changes 1`] = ` +

+ Constraint not available for this + gene +

+`; + +exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a minimal transcript has no unexpected changes 1`] = ` +

+ Constraint not available for this + transcript +

+`; + +exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` +[ + + + + + + + + + + + + + + + + + +
+ Category + + + + Expected + + + + Observed + + + Constraint metrics +
+ RNA variant + + 22.2 + + 1.10 + + o/e = + 0.33 + ( + 0.31 + - + 0.35 + ) +
, + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] +`; + +exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` +[ + + + + + + + + + + + + + + + -
+ Category + + + + Expected + + + + Observed + + + Constraint metrics +
+ RNA variant + + 22.2 + + 1.10 + + o/e = + 0.33 + ( + 0.31 + - + - - 0 - - - - - - 1 - - + 0.27 + + )
-
-`; - -exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a minimal gene has no unexpected changes 1`] = ` -

- Constraint not available for this - gene -

-`; - -exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a minimal transcript has no unexpected changes 1`] = ` -

- Constraint not available for this - transcript -

+ , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; -exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial RNA gene has no unexpected changes 1`] = ` - - - - - + + - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - 0.35 - ) -
-`; - -exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial RNA gene highlights upper LOF OE CI if below 0.27 1`] = ` - - - - - + - + - - - - - - - - - - + + + + - -
- Category - - - + Expected + + - Expected - - - + Observed + + - Observed - - - Constraint metrics -
- RNA variant - - 22.2 - - 1.10 - - o/e = - 0.33 - ( - 0.31 - - - +
- 0.27 - - ) - -
-`; - -exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial protein gene has no unexpected changes 1`] = ` - - - - - + + + + + - + + + + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - + + 0.23 + + 0.22 + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) +
- Expected - - - + + 0.34 + + 0.33 + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) +
- Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - 0.90 - ) -
+ pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + 0.90 + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial protein gene highlights upper LOF OE CI if below 0.058 1`] = ` - - - - - + + - - - - - - - - - - - - - - - - - - - - - - - - -
- Category - - - +
- Expected - - - + - Observed - - - Constraint metrics -
- Synonymous - - 0.23 - - 0.22 - - o/e = - 0.91 - ( - 0.80 - - - 0.95 - ) -
- Missense - - 0.34 - - 0.33 - - o/e = - 0.89 - ( - 0.80 - - - 0.99 - ) -
- pLoF - - 0.12 - - 0.11 - - o/e = - 0.79 - ( - 0.60 - - - + Expected + + + - 0.06 - - ) - -
+ + Observed + + + + Constraint metrics + + + + + + + Synonymous + + + 0.23 + + + 0.22 + + + o/e = + 0.91 + ( + 0.80 + - + 0.95 + ) + + + + + Missense + + + 0.34 + + + 0.33 + + + o/e = + 0.89 + ( + 0.80 + - + 0.99 + ) + + + + + pLoF + + + 0.12 + + + 0.11 + + + o/e = + 0.79 + ( + 0.60 + - + + 0.06 + + ) + + + + , + "Constraint metrics based on transcript", + " ", + + transcript-999 + . + 12.34.5 + , +] `; exports[`ConstraintTable with "gnomad_sv_r4" dataset selected with a mitochondrial transcript has no unexpected changes 1`] = `