diff --git a/src/Rmain.cpp b/src/Rmain.cpp
index c9386fc..3459c65 100755
--- a/src/Rmain.cpp
+++ b/src/Rmain.cpp
@@ -3,7 +3,12 @@
 ///#ifdef _WIN32 //  Windows
 #if defined(_WIN32) && !defined(__MINGW32__) //  Windows and not MINGW
 #define cpuid(info, x)    __cpuidex(info, x, 0)
-#else //  GCC Intrinsics
+#elif defined(__ppc64__) || defined(__PPC64__) || defined(__s390x__) || defined(__aarch64__)
+void cpuid(int32_t out[4], int32_t x) {
+     // Just disable it as anything better is unimplemented.
+     out[0] = 0;
+}
+#else // GCC Intrinsics on x86_64
 #include <cpuid.h>
 void cpuid(int info[4], int InfoType){
   __cpuid_count(InfoType, 0, info[0], info[1], info[2], info[3]);
diff --git a/src/kmers.cpp b/src/kmers.cpp
index 651887b..5340055 100644
--- a/src/kmers.cpp
+++ b/src/kmers.cpp
@@ -1,6 +1,8 @@
 #include <stdlib.h>
 #include "dada.h"
+#if ! (defined(__ppc64__) || defined(__PPC64__) || defined(__s390x__) || defined(__aarch64__))
 #include "emmintrin.h"
+#endif
 // #if _WIN32
 // #include <intrin.h>
 // #endif
@@ -26,6 +28,15 @@ double kmer_dist(uint16_t *kv1, int len1, uint16_t *kv2, int len2, int k) {
   return (1. - dot);
 }
 
+// These should never be called, but the symbols will have to exist
+#if (defined(__ppc64__) || defined(__PPC64__) || defined(__s390x__) || defined(__aarch64__))
+double kmer_dist_SSEi(uint16_t *kv1, int len1, uint16_t *kv2, int len2, int k) {
+    return 0.0;
+}
+double kmer_dist_SSEi_8(uint8_t *kv1, int len1, uint8_t *kv2, int len2, int k) {
+    return 0.0;
+}
+#else
 // Computes kmer distance with SSE2 intrinsics.
 double kmer_dist_SSEi(uint16_t *kv1, int len1, uint16_t *kv2, int len2, int k) {
   size_t n_kmer = 1 << (2*k); // 4^k kmers
@@ -87,6 +98,8 @@ double kmer_dist_SSEi_8(uint8_t *kv1, int len1, uint8_t *kv2, int len2, int k) {
   dot = ((double) dotsum)/((len1 < len2 ? len1 : len2) - k + 1.);
   return (1. - dot);
 }
+#endif
+
 
 // Computes "kmer distance" with SSE2 intrinsics, based on ordered kmers (e.g. gapless align)
 // If different lengths, returns -1 (invalid)
@@ -106,6 +119,11 @@ double kord_dist(uint16_t *kord1, int len1, uint16_t *kord2, int len2, int k) {
   return (1. - dot);
 }
 
+#if (defined(__ppc64__) || defined(__PPC64__) || defined(__s390x__) || defined(__aarch64__))
+double kord_dist_SSEi(uint16_t *kord1, int len1, uint16_t *kord2, int len2, int k) {
+    return 0.0;
+}
+#else
 // Computes "kmer distance" with SSE2 intrinsics, based on ordered kmers (e.g. gapless align)
 // If different lengths, returns -1 (invalid)
 double kord_dist_SSEi(uint16_t *kord1, int len1, uint16_t *kord2, int len2, int k) {
@@ -138,6 +156,7 @@ double kord_dist_SSEi(uint16_t *kord1, int len1, uint16_t *kord2, int len2, int
   dot = ((double) dotsum)/((len1 < len2 ? len1 : len2) - k + 1.);
   return (1. - dot);
 }
+#endif
 
 void assign_kmer8(uint8_t *kvec8, const char *seq, int k) {  // Assumes a clean seq (just 1s,2s,3s,4s)
   int i, j, nti;