batch effort remove

[hengbingao]

Hi anders,

Very powerful and effective tools for single cell methylation data analysis, but I wonder if you have consider the batch efforts across different library, and how to remove batch effort through MethSCAn. I think it will be nice if you could supply some strategy which could help to remove batch efforts based on MethSCAn.

Kinds regards,
Hengbin

[LKremer]

Hi Hengbin,

this is a great question but unfortunately I don't have a satisfying answer. In principle it should be possible to adapt one of the many batch correction or integration methods from single-cell RNA-seq to single-cell methylation data. However I have never tried this, so I'm not sure how easy it would be. I will let you know if I ever find out how to do this!
Lukas