diff --git a/src/preamble.js b/src/preamble.js
index b256582a05589..4f4dc32dba0ca 100644
--- a/src/preamble.js
+++ b/src/preamble.js
@@ -603,8 +603,13 @@ function instrumentWasmTableWithAbort() {
 }
 #endif
 
+#if SINGLE_FILE
+// In SINGLE_FILE mode the wasm binary is encoded inline here as a data: URL.
+var wasmBinaryFile = '{{{ WASM_BINARY_FILE }}}';
+#else
+var wasmBinaryFile;
 function findWasmBinary() {
-#if EXPORT_ES6 && USE_ES6_IMPORT_META && !SINGLE_FILE && !AUDIO_WORKLET
+#if EXPORT_ES6 && USE_ES6_IMPORT_META && !AUDIO_WORKLET
   if (Module['locateFile']) {
 #endif
     var f = '{{{ WASM_BINARY_FILE }}}';
@@ -614,7 +619,7 @@ function findWasmBinary() {
     }
 #endif
     return f;
-#if EXPORT_ES6 && USE_ES6_IMPORT_META && !SINGLE_FILE && !AUDIO_WORKLET // In single-file mode, repeating WASM_BINARY_FILE would emit the contents again. For an Audio Worklet, we cannot use `new URL()`.
+#if EXPORT_ES6 && USE_ES6_IMPORT_META && !AUDIO_WORKLET // In single-file mode, repeating WASM_BINARY_FILE would emit the contents again. For an Audio Worklet, we cannot use `new URL()`.
   }
 #if ENVIRONMENT_MAY_BE_SHELL
   if (ENVIRONMENT_IS_SHELL)
@@ -624,8 +629,7 @@ function findWasmBinary() {
   return new URL('{{{ WASM_BINARY_FILE }}}', import.meta.url).href;
 #endif
 }
-
-var wasmBinaryFile;
+#endif
 
 function getBinarySync(file) {
   if (file == wasmBinaryFile && wasmBinary) {
@@ -1079,7 +1083,9 @@ function getWasmImports() {
   }
 #endif
 
+#if !SINGLE_FILE
   wasmBinaryFile ??= findWasmBinary();
+#endif
 
 #if WASM_ASYNC_COMPILATION
 #if RUNTIME_DEBUG