diff --git a/src/wp-settings.php b/src/wp-settings.php
index 992c14026f88e..7c8413609eb5e 100644
--- a/src/wp-settings.php
+++ b/src/wp-settings.php
@@ -537,6 +537,16 @@
 // Load network activated plugins.
 if ( is_multisite() ) {
 	foreach ( wp_get_active_network_plugins() as $network_plugin ) {
+		/*
+		 * If the plugin is incompatible with this WordPress version,
+		 * skip loading the plugin.
+		 *
+		 * @since 6.5.0
+		 */
+		if ( ! $_is_plugin_compatible_with_wp( $network_plugin ) ) {
+			continue;
+		}
+
 		wp_register_plugin_realpath( $network_plugin );
 
 		$_wp_plugin_file = $network_plugin;