diff --git a/packages/components/CHANGELOG.md b/packages/components/CHANGELOG.md
index 74fe423a8b81c5..3d2ca92747d159 100644
--- a/packages/components/CHANGELOG.md
+++ b/packages/components/CHANGELOG.md
@@ -10,6 +10,7 @@
 
 -   `PaletteEdit`: Use consistent spacing and metrics. ([#61368](https://github.com/WordPress/gutenberg/pull/61368)).
 -   `FormTokenField`: Hide label when not defined ([#61336](https://github.com/WordPress/gutenberg/pull/61336)).
+-   `ComboboxControl`: supports disabled items ([#61294](https://github.com/WordPress/gutenberg/pull/61294)).
 -   Upgraded the @types/react and @types/react-dom packages ([#60796](https://github.com/WordPress/gutenberg/pull/60796)).
 
 ### Bug Fix
diff --git a/packages/components/src/combobox-control/README.md b/packages/components/src/combobox-control/README.md
index b84e01b7d6a077..fade4c66a796e3 100644
--- a/packages/components/src/combobox-control/README.md
+++ b/packages/components/src/combobox-control/README.md
@@ -77,7 +77,7 @@ If this property is added, a help text will be generated using help property as
 
 The options that can be chosen from.
 
--   Type: `Array<{ value: string, label: string }>`
+-   Type: `Array<{ value: string, label: string, disabled?: boolean }>`
 -   Required: Yes
 
 #### onFilterValueChange
diff --git a/packages/components/src/combobox-control/index.tsx b/packages/components/src/combobox-control/index.tsx
index 1bfcd430b3e905..b11a77b1dbdae6 100644
--- a/packages/components/src/combobox-control/index.tsx
+++ b/packages/components/src/combobox-control/index.tsx
@@ -78,10 +78,12 @@ const getIndexOfMatchingSuggestion = (
  * 	{
  * 		value: 'normal',
  * 		label: 'Normal',
+ * 		disabled: true,
  * 	},
  * 	{
  * 		value: 'large',
  * 		label: 'Large',
+ * 		disabled: false,
  * 	},
  * ];
  *
@@ -165,6 +167,10 @@ function ComboboxControl( props: ComboboxControlProps ) {
 	const onSuggestionSelected = (
 		newSelectedSuggestion: ComboboxControlOption
 	) => {
+		if ( newSelectedSuggestion.disabled ) {
+			return;
+		}
+
 		setValue( newSelectedSuggestion.value );
 		speak( messages.selected, 'assertive' );
 		setSelectedSuggestion( newSelectedSuggestion );
diff --git a/packages/components/src/combobox-control/stories/index.story.tsx b/packages/components/src/combobox-control/stories/index.story.tsx
index 9c0e5455ebc06c..e58f68277c916c 100644
--- a/packages/components/src/combobox-control/stories/index.story.tsx
+++ b/packages/components/src/combobox-control/stories/index.story.tsx
@@ -20,6 +20,17 @@ const countries = [
 	{ name: 'Albania', code: 'AL' },
 	{ name: 'Algeria', code: 'DZ' },
 	{ name: 'American Samoa', code: 'AS' },
+	{ name: 'Andorra', code: 'AD' },
+	{ name: 'Angola', code: 'AO' },
+	{ name: 'Anguilla', code: 'AI' },
+	{ name: 'Antarctica', code: 'AQ' },
+	{ name: 'Antigua and Barbuda', code: 'AG' },
+	{ name: 'Argentina', code: 'AR' },
+	{ name: 'Armenia', code: 'AM' },
+	{ name: 'Aruba', code: 'AW' },
+	{ name: 'Australia', code: 'AU' },
+	{ name: 'Austria', code: 'AT' },
+	{ name: 'Azerbaijan', code: 'AZ' },
 ];
 
 const meta: Meta< typeof ComboboxControl > = {
@@ -111,3 +122,20 @@ WithCustomRenderItem.args = {
 		);
 	},
 };
+
+/**
+ * You can disable options in the list
+ * by setting the `disabled` property to true
+ * for individual items in the option object.
+ */
+export const WithDisabledOptions = Template.bind( {} );
+const optionsWithDisabledOptions = countryOptions.map( ( option, index ) => ( {
+	...option,
+	disabled: index % 3 === 0, // Disable options at index 0, 3, 6, etc.
+} ) );
+
+WithDisabledOptions.args = {
+	allowReset: false,
+	label: 'Select a country',
+	options: optionsWithDisabledOptions,
+};
diff --git a/packages/components/src/combobox-control/types.ts b/packages/components/src/combobox-control/types.ts
index 6a32fb17e16c08..ae20170629873c 100644
--- a/packages/components/src/combobox-control/types.ts
+++ b/packages/components/src/combobox-control/types.ts
@@ -6,6 +6,7 @@ import type { BaseControlProps } from '../base-control/types';
 export type ComboboxControlOption = {
 	label: string;
 	value: string;
+	disabled?: boolean;
 	[ key: string ]: any;
 };
 
diff --git a/packages/components/src/form-token-field/style.scss b/packages/components/src/form-token-field/style.scss
index 72a5b7929a7b04..57435a3f62ad26 100644
--- a/packages/components/src/form-token-field/style.scss
+++ b/packages/components/src/form-token-field/style.scss
@@ -181,4 +181,13 @@
 		background: $components-color-accent;
 		color: $white;
 	}
+
+	&[aria-disabled="true"] {
+		pointer-events: none;
+		color: $gray-600;
+
+		&.is-selected {
+			background-color: $components-color-accent-transparent-40;
+		}
+	}
 }
diff --git a/packages/components/src/form-token-field/suggestions-list.tsx b/packages/components/src/form-token-field/suggestions-list.tsx
index 328bbed9d4eb89..43a9b87c2030b3 100644
--- a/packages/components/src/form-token-field/suggestions-list.tsx
+++ b/packages/components/src/form-token-field/suggestions-list.tsx
@@ -19,7 +19,9 @@ const handleMouseDown: MouseEventHandler = ( e ) => {
 	e.preventDefault();
 };
 
-export function SuggestionsList< T extends string | { value: string } >( {
+export function SuggestionsList<
+	T extends string | { value: string; disabled?: boolean },
+>( {
 	selectedIndex,
 	scrollIntoView,
 	match,
@@ -103,10 +105,18 @@ export function SuggestionsList< T extends string | { value: string } >( {
 		>
 			{ suggestions.map( ( suggestion, index ) => {
 				const matchText = computeSuggestionMatch( suggestion );
+				const isSelected = index === selectedIndex;
+				const isDisabled =
+					typeof suggestion === 'object' && suggestion?.disabled;
+				const key =
+					typeof suggestion === 'object' && 'value' in suggestion
+						? suggestion?.value
+						: displayTransform( suggestion );
+
 				const className = clsx(
 					'components-form-token-field__suggestion',
 					{
-						'is-selected': index === selectedIndex,
+						'is-selected': isSelected,
 					}
 				);
 
@@ -134,16 +144,12 @@ export function SuggestionsList< T extends string | { value: string } >( {
 						id={ `components-form-token-suggestions-${ instanceId }-${ index }` }
 						role="option"
 						className={ className }
-						key={
-							typeof suggestion === 'object' &&
-							'value' in suggestion
-								? suggestion?.value
-								: displayTransform( suggestion )
-						}
+						key={ key }
 						onMouseDown={ handleMouseDown }
 						onClick={ handleClick( suggestion ) }
 						onMouseEnter={ handleHover( suggestion ) }
 						aria-selected={ index === selectedIndex }
+						aria-disabled={ isDisabled }
 					>
 						{ output }
 					</li>
diff --git a/packages/components/src/utils/theme-variables.scss b/packages/components/src/utils/theme-variables.scss
index 14e44f3ddc7d2f..8c8c2d8a5633f7 100644
--- a/packages/components/src/utils/theme-variables.scss
+++ b/packages/components/src/utils/theme-variables.scss
@@ -4,6 +4,10 @@
 // `--wp-admin-theme-color`. If the `--wp-admin-theme-color` variable is not
 // defined, fallback to the default theme color (WP blueberry).
 $components-color-accent: var(--wp-components-color-accent, var(--wp-admin-theme-color, #3858e9));
+
+// Define accent color transparent variants.
+$components-color-accent-transparent-40: rgba(var(--wp-components-color-accent--rgb, var(--wp-admin-theme-color--rgb)), 0.04);
+
 $components-color-accent-darker-10: var(--wp-components-color-accent-darker-10, var(--wp-admin-theme-color-darker-10, #2145e6));
 $components-color-accent-darker-20: var(--wp-components-color-accent-darker-20, var(--wp-admin-theme-color-darker-20, #183ad6));