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GPRuler has corrected grRules for 889 reactions (S5 File). Overall, the essential gene analysis was improved:
(where "V" stands for viable and "N" for non-viable after KO). So both true positives (0.789 -> 0.795) and true negatives (0.03 -> 0.039) increased. As part of that, grRules were defined for 267 reactions that previously had no grRule. These results should be validated and improvements should be included.
Suggested solution:
One could directly include the new grRules, but it would be good to have a closer inspection of the results first.
GPRuler used Yeast 8.3.4, so rerun their pipeline with Yeast 8.5.0.
Check if essentiality predictions worsened for any of the genes: those that were True Positive or True Negative in Yeast8 but False Negative or False Positive in GPRuler. Otherwise, the new grRules can probably be applied?
The text was updated successfully, but these errors were encountered:
Description of the issue:
GPRuler has corrected grRules for 889 reactions (S5 File). Overall, the essential gene analysis was improved:
(where "V" stands for viable and "N" for non-viable after KO). So both true positives (0.789 -> 0.795) and true negatives (0.03 -> 0.039) increased. As part of that, grRules were defined for 267 reactions that previously had no grRule. These results should be validated and improvements should be included.
Suggested solution:
One could directly include the new grRules, but it would be good to have a closer inspection of the results first.
GPRuler used Yeast 8.3.4, so rerun their pipeline with Yeast 8.5.0.
Check if essentiality predictions worsened for any of the genes: those that were True Positive or True Negative in Yeast8 but False Negative or False Positive in GPRuler. Otherwise, the new grRules can probably be applied?
The text was updated successfully, but these errors were encountered: