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dWIZGenomics

The goal of dWIZGenomics is to provide the code used to reproduce the figures containing the genomic data for the publication "A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction"

Instructions

The figures can be reproduced by running the code in the vignettes. Install the package by following the next steps:

  1. Clone the repository
git clone https://github.com/Novartis/dWIZGenomics.git

  1. Download the data files available in the zenodo repository into the directory dWIZGenomics/inst/zenodoData

  2. Download the bigwig files from the GSE247096 entry into the directory dWIZGenomics/inst/bigwigs/GSE247096.

  3. Load the package via devtools::load_all(). Alternatively, you could also install the package but you would copy some large files (bigwigs) into your .libPaths()

  4. Run the code in the vignettes.