ETKDG.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## ETKDGv3"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Minitutorial to create some 2D and 3D representations of organic molecules"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "from rdkit import Chem\n",
    "from rdkit.Chem import AllChem"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1e39d624430>"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Upload a molecule from SMILES\n",
    "\n",
    "mol = Chem.MolFromSmiles('[H][C@]12CCCC[C@]11CCN(C)[C@H]2CC2=C1C=C(OC)C=C2')\n",
    "mol"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1e3b451f300>"
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Add H\n",
    "\n",
    "mol = Chem.AddHs(mol)\n",
    "mol"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1e3b451f300>"
      ]
     },
     "execution_count": 5,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# Apply ETKDG to generate 3D geometry\n",
    "\n",
    "AllChem.EmbedMolecule(mol, AllChem.ETKDGv3())\n",
    "mol"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1e3b451f8b0>"
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "Curcumin_SMILES = \"COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O\" #Add SMILES from Curcumin\n",
    "\n",
    "Curcumin = Chem.MolFromSmiles(Curcumin_SMILES) # Generate the molecule\n",
    "\n",
    "Curcumin = Chem.AddHs(Curcumin) #Add H\n",
    "\n",
    "AllChem.EmbedMolecule(Curcumin, AllChem.ETKDGv3()) # Generate the molecule\n",
    "\n",
    "Curcumin #Show results"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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gICA8PDwhIaGurk47kXQoJyenX79+AJYsWZKcnKzqXd41VVXs7Fn22Wds/nzm4KCYH21s2PHjLS2XLWu56OLCNm9mx46x48fZ1q3Mw6Plup9f78ikb7/9NoBt27YpXJ80aRKA06dP8xFUB7gBcY381GQ/OgY1JydHaQN5zfIvv/yi/svxhdKoJlVWVnI3cZ9++mlISMjTTz9tZmbWOqWamppOnTp17dq13377bWFhoXaiaquuro6rxZETCoVisXjhwoXh4eFpaWlNHd6Pd0Z5OUtIYGFhzM+PDRnCAJaczBhju3e35MoPPlC88ZfJ2LZtTCBgANuwQQMx8G337t0A/vznPytcDwwMBBAeHs5LVO0oKSkBYGFhoZH3AKVRXaeDafSzzz4D4OvrK7/S1NTE1RIFBgaKxWKDx89NsrW19fPzk0qlsbGx2pzoX7VqFYCRI0f+4x//WLp0qYuLi0KRk4WFxbRp0957772jR49qbI+rmzdZfT2rq2ODBzOAqV50yFasYAAzNmZ372rmpfmTkpICYNy4cQrXuT0cli5dyktU7YiOjgYwffp0jTwbpVFdJ0+jd+/erVVGfnKydtJoY2Mjt8PeTz/9pKpNRUVFQkJCWFiYn5/fwIED2/YHAwMDe7o88+TJkwKBQCQSpaSkyC8+fPgwISEhPDx84cKFYrFY8PiBa1ZWVjNmzJBKpdHR0XfVTG3HjrV0RdvZnaCoiAmFDGD//Kdar6UDampqDA0NhUKhwnhOYmIigIkTJ/IVmCobNmwAEBoaqpFnozSq6+RptEPaSaOHDh0C4OTk1Nzc3MkvuXHjBlf0LpFIFEZU+/fvL89cDzRXnllSUjJ06FAoG61rTWmRE+fdCRPUKnIKCmIAe+KJDppJJAxgL73UtSfXSU5OTgAyMjJaX6ysrBQIBP369WtoaOArMKVmzZoF4NixYxp5tj6SRnvD7vc2NjYCZcfVNjc3P3jwQGthcDv3vPfeewadPvHYwcHBwcFh0aJFAKqrqzMyMtLT05OSks6ePVtSUhIXFxcXFydvKZFI3N3dfXx8JkyY0PmXaI0x9uabb965c+eZZ57hdutRhet+zpgxg/vr9evXL1y4cOHChdTU1OdNTZGRgZgYxMQAgFCIsWPh6QkvL3h5QSyGsN03FbfP5rhxHcQ6bhySktArNuV0c3PLy8u7fPny+PHjT58+/dVXX9XV1Xl7e9vb29++fTs/P1++FIJ3jLG0tDQA8gI+0il85/Hu69LYaG1t7TPPPLN27drvvvuuJ+Z24uPjAQwePFgzU96MFRYWRkdHh4aGSiQShSP25Kszo6KiSkpKOv+c//znPwEMGjRIrX+B9oucRCLm7q68yInDzcUvXtzBq6xfzwA2ZEj349QZ3F63a9asOXfunLDNZ4yzs3NgYGB4eHhsbKxCean25efnQ9l6gW6j3mivkp6efubMmTNnznB/tbW15Xp2EonEw8ND/aNAucmlVatWaepUUTs7Ozs7O27xdVNTU15eXlJSUmJiYnp6em5ublJSUlJS0vbt2wHY2tpy34i7u7unpydXxtRWdnb2unXrAOzZs8fOzq77kRkawsUFLi5YtAgAampw8SIuXEBqKi5cwI0bSE+HfE/igQPh5QVPT0gkeO45AOB2j+6wN801kMm6H6fO4Ioi4uLivvzyy6amJhsbm4EDB967d6+xsbGysvLq1atXr16VN7azs3N5ZOzYsWKx2NLSUmuhpqamAuCKsTTr6aefVnpGJOsVu4n3lTTq5uZ24sSJ8+fPnz9/PiUlpbi4OCYmJiYmBoCxsfHEiRO9vb0nT548efLkYcOGdfXJ8/LyTp48aWpqqvRk2pkzZxYVFckzXdsJnA4JhULu54qrkrlz586FCxfS09PT09MTExO5zZm4zflFIpGrq6v89t/BwYF7hrq6ugULFtTW1q5cuXLu3Lld/QbbY2oKHx/4+LT8taICWVlIT0dSEs6eRUkJTp7EyZN45pmWNNq/f0uz9pWXA4C1tSZD5QmXRi9fvgxg5cqVO3bskI/JlJWV5eTk5Obm5uTkpKenX758uaioqKioKDY2Vv7ltra2Li4uYrGY+338+PHyrbg17sKFCwA8PT01/szaHF7Tvr6SRs3NzWfPns1tYAygoKCA69klJSVlZGScO3fu3Llz3ENcR1XeVzUxMenwyT/99FOZTLZkyZJBrc+ABACUlZWlpKQ8fPgwNzeXKyEcMmSIt7f3pEmTJk+e7OHh0Y0fCW5zEHlHNTs7Ozk5OSUl5fz58/n5+Vx65VoOHz7c29vb29v73LlzWVlZYrF427ZtXX25runfvyWrrl4NALdutfRSR49uaeDggPh4tOp/KceNij76GNBrhw8f5v4QEhLCrbOUs7a29vHx8ZF/CAFFRUVcVuV+v3TpUnFxcXFxsXyUHG0S68SJE01NTTUSKtcb7fbA6IMHDy4+kpGRcfHiRflDGRkZzs7Obb/k4cOHg3vBEbZ8jyp0n6bqRisrK+VFSAp5UKEISemXl5SUmJiYGBgY5Ofnt310zZo1IpFozpw5W7ZsCQgIUHjHGBoati567/wUvyqtC6pafy9WVlYCgaD92Xkt2buXAczQkLUzPltVxSwsGMA2bdJiZJonk8m4qTxDQ8OdO3d270kKCwtjY2O5WjR3d/e2n+uGhoYODg5+fn6hoaGRkZFpaWndG6BvaGgwMTERCASlnd7WoKysrJ06uYSEhD4yNkppVJG8CMnd3b0z1fJcnd28efOUPttbb73FPcnAgQO3b9/e0NDQztyRhYWFRCIJDQ3VQHkmYzKZLDc3d9++fcuXL5dIJNxLzJw5k+fjpB48YCYmDGDr1qlsExHBAGZgwK5d02JkGlZfXz9//nwA/fr10+DWoo2NjTdu3IiOjg4LC+MSa9vRcKFQ2DqxZmdnd2ZJEjdH385R5OzRzCf30mKxWOF1zc3N3d3duW4Bt/SZ0qiu08IqpoqKitjY2E2bNr3wwgsDBgxo/Y4RiUReXl4rV67kZgASExNVPUlOTo58MMHR0bH1T1RDQ0NaWpr8w1zhTdl6MX59fX33vgX5C+3atYurADUwMFi4cGFxcbE6T6iWv/6VAczIiMXFKXk0LY1ZWjKALVig9cg05uHDh8899xwAKyurM2fO9OhrNTQ0cIlVKpUGBASIxeK2kzkikUgsFgcEBEil0qioqOzs7La3Pjt37kSbdatc3uQqiG1tbRWelvvgl2/p3TZZUxrVdYmJiU5OTk5OTlVVVUobXL9+nWtwTUOdmsLCwqioKIVq+SFDhhgZGe3atav9D/zY2Fh5eaCvr69CMTanqKiIe8vOmDFDYbTLzMxM/n7t9mb7paWloaGhXOfFzMxMKpVqqjyra2pq2PjxLZn03XdZVhZraGBNTSwvj334ITMzYwBzcNDfPaHv3LkzYcIEAEOHDlX6H93T6uvrs7Ozo6Ki5Im1baGxkZGRPLFGR0ffuHHjjTfeALBp0yZ53mw7amlpadk6b3Y4DEVplLSnsrLy1KlTH330EbdlJ4AJEybEx8e38yVcl5B7axoYGAQEBLSzXF1+sAe3GF9h1IkbXggLC0tISOjqYvy8vDzuKF0A9vb2kZGRPJwLUlbGZs9+rODUwOCPP0skrKhI2yFpSEFBwVNPPQXAwcFBU5/f6qusrExJSdmzZ8+aNWuee+45peUoStd0DB48+Pnnn1+3bt2xY8cKCgq6+rqURkmnyGSyqKgo+dFMM2bMaH8MoXWX0NTUNDQ0tLKyssNX4YYXuD6CRhbjnzp1Sr7Jk5eXV1JSUme/YQ2KjWVvvsnGjGHW1szCgjk6sj//mf3wg5KifT2RlpbGfUx6eHh0aWWE9pWXl6elpUVGRoaGhvr5+Tk4OAgEAkNDQysrKw0evUVplHRBfX19eHg4N04qEokCAwPbnyO6deuW/PSRYcOGdTgmoKD1YnyRSNQ6q7ZejN/+lGtzc3NkZCS3xF4gEAQEBOjR2Xw6KD4+nnsDPPvss535aNQ1o0ePBqC04KTbcnNzjY2NjY2Nr1y5orRBZWUl1yBO6UC5nqA0qkn37t0LCgriBvitra3DwsLa36c5OTl58uTJXPpzd3f/9ddfu/Gi8uEFf39/hcEskUikauBYrqqqSiqVcjUDJiYmoaGher0POV++++477t/w9ddf17XdRjqJq7pPTU3lOxD9Q2lU83Jzc//0pz9xieypp55qv9iFGxN44oknuPZ+fn5qDqi1Lqjy9PTs5Ff99ttv8t6xnZ1dV3vHfZx8YVJQUJD6xb98mTlzJtqcd0I6g9JoT4mNjR33aB8jbh1RO42rq6vDwsJajwncu3dP/Ri6+iOdmpoqrzCdOHGibh5xoVNkMplUKuVGRaRSKd/hqIWbeNRgiWvfQWm0BzU2Nu7atWvIkCHywcf//ve/7bQvLCwMDAzkxgQGDBjQ4ZhAT2g7Y6ZqcoCwxsbad955xt5eKBR+/fXXfEejrmXLlgHYtWsX34HoH0qjPe7hw4fywcfOTM23U66vNTU1NT3RO+5VamrYnDkMqHN2Pqn6vAM9EhISAmDr1q18B6J/KI1qye3bt7s0+NiZcv2e1nrGjOsdq7mYqvcoLWVTpzKAWVsz1QvY9MuWLVsArGtnkS5RgdKoVqWkpHR+8LFL5fo9Rxd6x7qlqIi5uTGA2dmxy5f5jkZjuFP2Vq5cyXcg+ofSqLZpp1xf41r3jp999tnMzEztx6ATcnPZiBEMYGIxu32b72g0idvQ77XXXuM7EP1DaZQfbQcfe7RcXyPa7m/C+6EX2paaymxsGMAmTWK9brD4xIkTAGbPns13IPqH0iifeCnXV9ODBw9CQ0O5nVn43N9E+2JjW3ZB9ffv8nmo+oDbuXzy5Ml8B6J/KI3yLzc394UXXuCrXL97dGJ/E206cICJRAxgixYx/Vyk1KHc3FwAY8aM4TsQ/UNpVFfoQrl+V+nE/iZaEB7esgFVUJD+bpvSoeLiYmj0WNC+g9KoDuHK9bmp+U6W6y9dupRbhrhv3z5thfmYXr6/iUzGQkIYwAQCpgtHsPSkuro6AP369eM7EP1DaVTndLVcPyMjY8WKFfwu5e6d+5s0NrI33mjZXvqbb/iORhu4/8G+MtitOZRGdVTrqXl92SukV+1vUlXVsrG0uTn7+We+o9ES7q6CzwNm9BOlUZ12/vz5KVOm6NdeIQr7m/BSTqCuBw/YlCkMYEOGsLQ0vqPRHu4MZFV7gxJVKI3qOoWp+Q7L9XWBTCY7ePCgvb09F/PLL78cERGRmJjY4eanOuHmTebkxAA2ahTLy+M7Gq3iyunan94kbVEa1Q9dLdfXBTU1NVu2bDEwMJBvJm1oaCgWi+UH8OpiVr1/n9nZMYBNmMD63r0tt+r3xIkTfAeiZwSMMRA9cf/+/c2bN3/xxRfNzc3W1tahoaHBwcFtjynXHV999dWbb75pZ2c3e/bsixcvZmdnNzY2yh8VCoVjxoxxf2T8+PEmJiY9GE1lJeLjcfky7t+HkRHs7ODjA3d3KBxHvG4dkpPx/ffo378Hg9FJCxYs+Oabbw4fPvzaa6/xHYte4TuPky67dOnSjBkzuP++KVOmrFq16sCBA5o9QkcjmpqaHB0dARw8eJC70tDQwB13yp0ipfABoNBXrdbgSqH6erZ+fcvRzQq/nJ1ZTMxjjWUy1lc3slqxYgWAL7/8ku9A9Az1RvVVXFzc6tWr+/Xrl5GRwV2xtLQcN26cj4+PRCLx9vbmFr/3NJlMNnfu3Llz5y5ZskQoFLZ+6MiRI6+++qqDg0NeXp7CQ5y6urrMzMz09PT09PS0tLTc3Nympib5o0KhcNqUKbFPPgl3d3h4wNUVxsbdCbGmBnPm4NQpAPDwwJw5GDkStbXIykJUFO7dg4EBwsOxalV3nrx3Wbdu3SeffPLxxx//7W9/4zsWvcJ3Hifd19zcfO7cuU8++eTFF1+0tbVt/d8qEAgcHR0XLly4Y8eO1NTUnjtkrbCw0NXVdeTIkd7XKRAAAAiQSURBVG1fYuLEiejKbupt+6qzPTz+6DYKhUwsZgsXsvBwlpDAamo6G+LKlS1fvmeP4kNlZczPjwHM0JCdOdPZJ+y9tm7dCiAkJITvQPQMpVGdNmzYsP79+x86dEhVA09Pz/79+//9739njw6zk0qlM2bMMDU1bZ1VRSJRN86y7ySZTNZ2I9Qff/wRwNChQ7tdy11dXf17SgrbsYMtXszGjmWGho/djItEbMIE9pe/sJ07WWoqU7WlS14eEwgYwLZsUd6gro6JxQxgXl7di7M32bVrF4DAwEC+A9EzSm61iO4oLy+vrq5uaGhQ1aCysrKiooJbxmdnZ2dnZ+fv7w+gubn56tWr3P1yUlJSRkZGbm5ubm7u7t27AfTv39/T01Mikbi7u0+ZMmXgwIHqBCkQCEaMGKFwMSwsDEBISIhx9+7EAVNTU1MvL3h5tfy9sRH5+UhPb/l14QIyMpCRgT17AEAohKMj3N3/+MXNVu3dC8ZgbY01a5S/TL9+kEoxfz5SU5GZiUdbBPRNVlZWAMrLy/kORM9QGu2dDA0NXVxcXFxcFi1aBODhw4fcKGRSUtLZs2dLSkri4uLi4uK4xra2ttyIqru7u6enp/pT/6dPn05KSho4cCB3SppmiERwcYGLCxYtAoDqaly69EdWvXoVubnIzcWBAy2NjxzBvHk4cwYAZs1qb1zV3x8iERobceZMH0+j1tbWAMrKyvgORM9QGu0TLCwsfHx8fHx8Vq9eDaCoqEjeUU1KSiouLj569OjRo0cBiEQiV1dXLqW6u7vLd7zvko8//hhAcHCwubm5Zr+RP5iZQSLBo+VSaGhAVhYSE1uyal4eHBwAICcHAFxd23sqExM4OiInp6VxH0a90e6hNNoXtb79b2pqysvL41JqYmKifCiAazl06FAPDw8upUokkgEDBnT45KmpqXFxcZaWlm+//XbPfhutGRm13MtzqqpgYoKGBlRVAUCHoxaDBgFAaWlPhqgHKI12D6XRvk4oFLa+/a+srLx8+TKXUlNTU+/cuRMTExMTE8M1dnBwkHdUvby8uD3wFXBd0ZUrV3J3iPzgesHyMWWFAvu2uHqsVuVWfROl0e6hNEoeY2lpyd3+h4aG4tHtP5dV09PTCwoKCgoKDhw4AMDMzGz8+PHyNUjc7X9ubu6PP/5obGwcFBTE83cCwMQERkZoaEBlZQctKyoAwMpKC0HpMisrK4FAUF5ezhjjduoinUFpVA/861//io+PV/oQt2N5z2l9+9/Q0JCRkZGSkpKampqSknL9+nVuaJVrOWzYsEmTJhUUFMhksmXLlinUsfLmiSeQn4/8/PbaMNbS4NFxrX2WSCQyMzOrqqqqrq7uwXHtXofSqB44d+4cd9wYv4yMjCZNmjRp0iTur61v/8+fP19YWPjdd9/169fPwMCgsLCwuLhYJzLppEnIz2+Zr1clPb2lu+rtrZ2gdJmNjY2pqSml0S6hxaA6zdzcvLq6OigoyNfXV2mDt99+u7CwcNOmTRs2bNBybK0xxvLz81NTU8+ePbt///6GhgZzc/OQkJB3331XYSGAtv30E/z8ACA+HtOnK2+zZAkiI2Fri//+F8pGewnpAM/l/6RdZmZmaPecJScnJwCbNm3SYlAdyM/PDwgI4EbWhg0bxvMe+M3NzNWVAeypp5RvfHfsWMsyp08/1XpwOuHw4cP79u3LU72z6g8//LBv376LFy9qMyr9QmlUp+ljGuUo7NsfHx/PWyiZmczcnAHM3p59/TUrL2+5np/P1qxhQiED2LRpTH/PO1EPV1DRztYHrq6uANavX6/NqPSLAU+dYNLLTZo0KTExMSoqatSoURcvXvT19Z05c2Z2djYPobi6Ij4e9vb47TcsWQIrK1hbw8wMjo74xz/Q1IT/+R/89FPHRVGEqEBplPQU7rzlq1evhoeH9+/fPy4ubsKECcuXL7979662Q/H0RF4eIiLg64sBA1BejsZG2Ntj4UKcOoVjx8DvAC7Rc5RGSc8yMjJavXr1jRs3uErS3bt3jx49euPGjdx2KtpjYoKgIJw6hQcP0NiIhgbcvo39+6Fi7o6QzqM0SrRh4MCBERERWVlZAQEBVVVVH374oaOj4/79+xkvhSLK9pAmpNsojRLtcXZ2joqKiouLc3Nz++233xYvXswNofIdFyFqoY9lnfbLL780Nzdz0/FKHTx4sKamRn78sl549tlnL168ePDgwffff//ChQtTp0718/OLiIhw4PZkInyorq5+8OCB0oeam5u1HIz+4btUgPRdVVVVYWFhFhYWAIyMjIKCgsrKylo3+P333+fNmzdv3rzbt28rfYba2lquQUZGhlZC7oU6uYMMFTy1g1YxEZ5xq7D27t3b3Nw8YMCAkJCQv/71r9zeUVeuXBGLxQCysrLGjh3b9murqqq4LHzy5Mnnn39ey5H3DgMGDCgrKxs0aBD3L9lWYWFhQ0PD+vXrN2/erOXY9AWNjRKecSudUlNTp02bVlpa+v77748bN47bQ5pozZYtWwpUcHZ25js6XUdplOiEiRMnnj59+vvvv3dycsrPz3/llVe+/PJLvoMipFMojRIdMnfu3KysrF27djk7O7/66qt8h0NIp1AaJbpFJBIFBgbm5OR05sASQnQBpVGiiwwM6J1J9AbVjRI98MMPP6SlpbW9Xl9fr/1gCFFAaZTogfXr1/MdAiEqURoleuD1118fqOyQ5MbGxp07d2o/nt5k/PjxFRUVNjY2qhqIxWKhUDhs2DBtRqVfqPye6C4qvyd6gQbyCSFELZRGCSFELZRGCSFELZRGCSFELZRGCSFELZRGCSFELVQ3SnSXjY2NVCoFMHjwYKUNjIyMuAZPPvmkViMjpBWqGyWEELXQTT0hhKiF0ighhKiF0ighhKiF0ighhKiF0ighhKiF0ighhKjl/wG69QknrQX10wAAAbZ6VFh0cmRraXRQS0wgcmRraXQgMjAyNC4wMy4zAAB4nHu/b+09BiAQAGJGBggQheIGRjYGBSDNwsagAaSYWTggNBOMZnOAiBNN4zCHEUwzMJJLcwOdzsikwcTIrMDMosDCmsHEypbAxp7BxM6RwMGZwcTJpcDFrcHExaPAyZLAwMvAwMfAwM/AKsDAJsjALsTAIczAI8LgBPI+GwsnBzsbqzgbIyQ4wEEiqv8zwmF27by9z5dW2vfZszvs6eez01/eYzeb+au99+059gE3l+4rvdFln/fOa39/Tprd67dv9p634d0/8cqzfXa3u/fZlSTu7/v9eL/59D37f0XI79+XJ3nAN1vhwK75Gnsvd9/Yv2Kn2IHzB6fZRZhv3CdTMWn/gYufbXL2tNqpHMncrxi1xc7h1BX7uv3Gdg8m/7VtaeZ3UP/8ef/vsEL7yIsyDjdPtDsc091pa1PeY5fhE+tQqj1pf4v5Cvu15UkOf3MV7FsiXtgn7+ew39mxav/hLSIHfhmc3i9Rk7hfqC36wPIzMQfkV2vbyf/jPFDa63EgK8re3u1dkV3y99P7Z6Sdsm877eUgBgDkf5AOAl8mdQAAAll6VFh0TU9MIHJka2l0IDIwMjQuMDMuMwAAeJx9VMtu2zAQvPsr+AMROPvg4xjbQVMUsYE27T/03v9HZ6W43FwqiTJFDsnZ2VmfSlzfr99+/yn/Lr2eTqXU/zxzzvJLa62ntxKdcn758vVWLu/P58fI5f7z9v6jCOKpcX/GPr/f3x4jKJeim84qdZanutXedYxSt9kd0XkAhUDZABU3TkOnCHfepFuHLpyWe8E2YejKjhBuEjurcIktoO3AOqwrYr5P6RWxo3iVtKPzZM4D3kiIPXf0g60512NB2wEVbuk9emPUNmp5wtYHgHR8Dyg2nq7NA9pEzMlEqAY1SNARUNm8NrdDJAPaiOVtore+oPOAqpOYRCzTzHYmag3iC4l6EADlmSFkldmbxhoCa4ofOKKaUPB8buUhEcVrTUwkIYWaUqnurh4d0YHOtBFmNQMjSzx8Vh++Z9uomRJJRaWntFOy12LcQKUFsE4GP4+8q6XI4QQq1/c+xhEYJvXEptFLcqLtSNfhu5WatMYjsQ241JRNUn/lvCu9tOdQVWSOXWBR16zRIJQIH6QlH5kflatIidXiOaQZWI4baykMh9abeWxLi0FTkujwHQqaRIMrzU7HRPja+SQkPghMtdFLMGG6G+OkU1pP2r/crp8q8KjJ8/12XTUZt6zKi1tXgXGu2CojsPkqFn6UtgrC2PoyvbGNZWxjm8u8xoZsUewvJCtKvCDJcthHNHnLYpUnC+0RWbLKPuDJEftAS5kHeaOn/ILMMVISQe6YKVUge8kZCVr8zcpnneP78b/J/ukvyKcKLHajTO8AAAGYelRYdFNNSUxFUyByZGtpdCAyMDI0LjAzLjMAAHicbVG7bhtBDPyVlDJwWizfpA+p3DiV0xsuAlUCYthwXPrjM1ylkRDc3R7J4fAx+/z48vRw+P50d6LT4fnx5e4/J10yHpa3Dnzfvg5HGlaiteGfxL7JIE+PHUBNS9/mKOUQ2XioTc79iAgJgTOHGLOB687K+xwUZmIAiCUpwEFcuxipcjMmV7gQLHbiKfuRUcVmdqRUNTY0EAVo+xHTiLgAC8XTBkvgbZpNN+vsqYShN3TxooimqVZ1O/JwRRIPMqc1CcqIN82Z1agxqZBszDJUGsvERF1H5vReGRKQxT/o0iySiLC0iWJVBERYVjkWkyYRmmY2yYxiVlsQMZV2GvjF6hXFMZciDIFlx6wkvFSUYm4Au5OAU9StqDNVl1CMFN0FK0ymJUZgl1azwihzV1yBcLT0BaFKLvVEAyy1iNrW9VD1RUobAEzSegJn90gAScZ326/Pt9efH2/v93Oc//x4ff99Pp0/B937tZvXLt1kE9/4t/l17fM1/+svty2r3JKMbQEAAAAASUVORK5CYII=",
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1e3b451f840>"
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "Aspirin_SMILES = \"CC(=O)OC1=CC=CC=C1C(=O)O\" #Add SMILES from Aspirin\n",
    "\n",
    "Aspirin = Chem.MolFromSmiles(Aspirin_SMILES) # Generate the molecule\n",
    "\n",
    "Aspirin = Chem.AddHs(Aspirin)\n",
    "\n",
    "AllChem.EmbedMolecule(Aspirin, AllChem.ETKDGv3())\n",
    "\n",
    "Aspirin"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1e3b451fdf0>"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "Gingerol_SMILES = \"O=C(C[C@@H](O)CCCCC)CCc1cc(OC)c(O)cc1\"\n",
    "\n",
    "Gingerol = Chem.MolFromSmiles(Gingerol_SMILES)\n",
    "\n",
    "Gingerol = Chem.AddHs(Gingerol)\n",
    "\n",
    "AllChem.EmbedMolecule(Gingerol, AllChem.ETKDGv3())\n",
    "\n",
    "Gingerol"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [],
   "source": [
    "from rdkit.Chem import Draw"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<IPython.core.display.Image object>"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "smiles_list = [\"COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O\", \"CC(=O)OC1=CC=CC=C1C(=O)O\",\n",
    "               \"O=C(C[C@@H](O)CCCCC)CCc1cc(OC)c(O)cc1\"]\n",
    "\n",
    "mol_list = []\n",
    "\n",
    "for smiles in smiles_list:\n",
    "    mol = Chem.MolFromSmiles(smiles)\n",
    "    mol = Chem.AddHs(mol)\n",
    "    AllChem.EmbedMolecule(mol, AllChem. ETKDGv3())\n",
    "    mol_list.append(mol)\n",
    "    \n",
    "img = Draw.MolsToGridImage(mol_list) #not ETKDGv3\n",
    "img"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## 3D visualization using py3Dmol"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [],
   "source": [
    "from rdkit.Chem import rdDistGeom\n",
    "from rdkit.Chem import rdDepictor\n",
    "from IPython.display import Image\n",
    "import py3Dmol\n",
    "from rdkit.Chem.Draw import IPythonConsole"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "The previous molecules will be used for the example. The"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [],
   "source": [
    "ps = rdDistGeom.ETKDGv3() \n",
    "ps.clearConfs= False #The previous conformations formed will not be deleted\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "        </div>\n",
       "<script>\n",
       "\n",
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       "  $3Dmolpromise = loadScriptAsync('https://cdnjs.cloudflare.com/ajax/libs/3Dmol/2.4.0/3Dmol-min.js');\n",
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       "viewer_1727295732511586.zoomTo();\n",
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       "viewer_1727295732511586.render();\n",
       "});\n",
       "</script>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "cid = rdDistGeom.EmbedMolecule(Aspirin,ps)\n",
    "\n",
    "v = py3Dmol.view(width=300,height=300) #adjust the size\n",
    "# v.removeAllModels() #Clear the visual screen,\n",
    "IPythonConsole.addMolToView(Aspirin,v,confId=cid)\n",
    "v.zoomTo()\n",
    "v.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "</script>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "ps = rdDistGeom.ETKDGv3() \n",
    "ps.clearConfs= False #The previous conformations formed will not be deleted\n",
    "cid = rdDistGeom.EmbedMolecule(Curcumin,ps)\n",
    "\n",
    "v = py3Dmol.view(width=300,height=300) #adjust the size\n",
    "v.removeAllModels() #Clear the visual screen,\n",
    "IPythonConsole.addMolToView(Curcumin,v,confId=cid)\n",
    "v.zoomTo()\n",
    "v.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
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       "\tviewer_1727295761735499.setStyle({\"stick\": {}});\n",
       "\tviewer_1727295761735499.zoomTo();\n",
       "viewer_1727295761735499.render();\n",
       "});\n",
       "</script>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "ps = rdDistGeom.ETKDGv3() \n",
    "ps.clearConfs= False \n",
    "cid = rdDistGeom.EmbedMolecule(Gingerol,ps)\n",
    "\n",
    "v = py3Dmol.view(width=300,height=300) #adjust the size\n",
    "v.removeAllModels() #Clear the visual screen,\n",
    "IPythonConsole.addMolToView(Gingerol,v,confId=cid)\n",
    "v.zoomTo()\n",
    "v.show()"
   ]
  }
 ],
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