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Disease Model Weights level 1 Model Weights level 2 Total cohort Total Prospective Total Positive stringent EHR label N(%) Total Positive broad EHR label N(%) Total positive in prospective set stringent N(%) Total positive in prospective set broad N(%) AUC stringent AUC broad False Positives based on stringent EHR labels False Positives based on broad EHR labels total predicted as positive Chart Review Top 100 all Chart Review Top 100 False Positives, how many truely have disease Estimated yearly new detection (of N yearly) AUC Average Precision
10ccs50:DiabMel w/cm model weights model weights 1531350 121195 27922(1.82%) 28473(1.86%) 2315(1.91%) 2368(1.95%) 0.74 0.74 2074 (of 121195) 2074 (of 121195) 0 high risk mrns high risk mrns 4385.3 to 4385.3(of 256259) 0.74 0.07
10ccs158.5:Chr ren fail stage 5+ model weights model weights 1636431 128865 1927(0.12%) 2097(0.13%) 156(0.12%) 164(0.13%) 0.82 0.82 134 (of 128865) 134 (of 128865) 0 high risk mrns high risk mrns 285.2 to 285.2(of 274273) 0.82 0.02
10ccs115:Aneurysm model weights model weights 1613299 127400 5713(0.35%) 6420(0.40%) 490(0.38%) 541(0.42%) 0.78 0.78 422 (of 127400) 422 (of 127400) 5 high risk mrns high risk mrns 896.7 to 896.7(of 270723) 0.78 0.02
10ccs116:Art embolism model weights model weights 1635440 129245 1168(0.07%) 1263(0.08%) 79(0.06%) 81(0.06%) 0.74 0.74 79 (of 129245) 79 (of 129245) 11 high risk mrns high risk mrns 167.7 to 167.7(of 274281) 0.74 0.00
10ccs127:COPD model weights model weights 1533488 121418 24415(1.59%) 26501(1.73%) 1995(1.64%) 2125(1.75%) 0.70 0.70 1779 (of 121418) 1779 (of 121418) 0 high risk mrns high risk mrns 3763.0 to 3763.0(of 256825) 0.70 0.04
10ccs142:Appendicitis model weights model weights 1640900 129199 1113(0.07%) 1161(0.07%) 100(0.08%) 104(0.08%) 0.56 0.57 83 (of 129199) 83 (of 129199) 35 high risk mrns high risk mrns 176.6 to 176.6(of 274886) 0.57 0.00
10ccs160:Urin stone model weights model weights 1589545 125575 12924(0.81%) 13671(0.86%) 970(0.77%) 1007(0.80%) 0.68 0.68 937 (of 125575) 937 (of 125575) 3 high risk mrns high risk mrns 1985.4 to 1985.4(of 266076) 0.68 0.02
10ccs171:Menstrual dx model weights model weights 1580629 124282 17767(1.12%) 18926(1.20%) 1576(1.27%) 1656(1.33%) 0.90 0.90 1218 (of 124282) 1218 (of 124282) 0 high risk mrns high risk mrns 2580.8 to 2580.8(of 263335) 0.90 0.09
10ccs172:Ovarian cyst model weights model weights 1630689 128275 972(0.06%) 2079(0.13%) 0(0.00%) 0(0.00%) nan nan 88 (of 128275) 88 (of 128275) 88 high risk mrns high risk mrns 187.1 to 187.1(of 272699) nan nan
10ccs173:Menopausl dx model weights model weights 1581394 124467 18074(1.14%) 20083(1.27%) 1310(1.05%) 1461(1.17%) 0.83 0.83 1331 (of 124467) 1331 (of 124467) 0 high risk mrns high risk mrns 2824.1 to 2824.1(of 264091) 0.83 0.06
10ccs174:Fem infertil model weights model weights 1637468 128992 1816(0.11%) 2109(0.13%) 125(0.10%) 138(0.11%) 0.94 0.93 130 (of 128992) 130 (of 128992) 0 high risk mrns high risk mrns 276.4 to 276.4(of 274239) 0.93 0.01
10ccs186:DM in preg model weights model weights 1640495 129344 1329(0.08%) 1443(0.09%) 139(0.11%) 151(0.12%) 0.92 0.90 95 (of 129344) 95 (of 129344) 0 high risk mrns high risk mrns 201.8 to 201.8(of 274746) 0.90 0.02
renal failure (stage 5, esrd, dialysis, eGFR <15) model weights model weights 1630413 128514 3311(0.20%) 3559(0.22%) 275(0.21%) 293(0.23%) 0.79 0.79 251 (of 128514) 251 (of 128514) 0 high risk mrns high risk mrns 533.9 to 533.9(of 273355) 0.79 0.02
10ccs199:Ulcer skin model weights model weights 1628142 128542 4785(0.29%) 4926(0.30%) 383(0.30%) 395(0.31%) 0.82 0.82 336 (of 128542) 336 (of 128542) 0 high risk mrns high risk mrns 713.3 to 713.3(of 272883) 0.82 0.02
10ccs652 hyperactivity model weights model weights 1605486 126512 6682(0.42%) 6929(0.43%) 590(0.47%) 622(0.49%) 0.78 0.78 471 (of 126512) 471 (of 126512) 0 high risk mrns high risk mrns 999.7 to 999.7(of 268534) 0.78 0.02
10ccs654 lang and dev disorders model weights model weights 1625816 127960 3208(0.20%) 3456(0.21%) 348(0.27%) 366(0.29%) 0.91 0.91 210 (of 127960) 210 (of 127960) 0 high risk mrns high risk mrns 446.5 to 446.5(of 272066) 0.91 0.04
10ccs655 anxiety disorder model weights model weights 1623098 127890 2440(0.15%) 2971(0.18%) 267(0.21%) 308(0.24%) 0.84 0.83 183 (of 127890) 183 (of 127890) 0 high risk mrns high risk mrns 389.1 to 389.1(of 271922) 0.83 0.01
10ccs657 Major depressive disorder model weights model weights 1524078 120424 20291(1.33%) 23853(1.57%) 1740(1.44%) 2070(1.72%) 0.68 0.67 1256 (of 120424) 1256 (of 120424) 4 high risk mrns high risk mrns 2661.1 to 2661.1(of 255139) 0.67 0.04
10ccs658 personality disorders model weights model weights 1642109 129247 712(0.04%) 814(0.05%) 62(0.05%) 71(0.05%) 0.85 0.85 39 (of 129247) 39 (of 129247) 0 high risk mrns high risk mrns 83.0 to 83.0(of 275059) 0.85 0.01
10ccs659 Delusional disorders and Schizophrenia etc. model weights model weights 1634587 128758 2082(0.13%) 2222(0.14%) 197(0.15%) 214(0.17%) 0.75 0.75 137 (of 128758) 137 (of 128758) 0 high risk mrns high risk mrns 291.3 to 291.3(of 273805) 0.75 0.01
10ccs2603:E Codes: Fall model weights model weights 1593161 125275 17810(1.12%) 18640(1.17%) 1592(1.27%) 1631(1.30%) 0.74 0.74 1258 (of 125275) 1258 (of 125275) 0 high risk mrns high risk mrns 2674.3 to 2674.3(of 266309) 0.74 0.04
10ccs15:Rctm/anus ca model weights model weights 1640794 129023 856(0.05%) 956(0.06%) 64(0.05%) 68(0.05%) 0.69 0.69 57 (of 129023) 57 (of 129023) 0 high risk mrns high risk mrns 121.5 to 121.5(of 274936) 0.69 0.00
dialysis model weights model weights 1633978 128965 2824(0.17%) 2992(0.18%) 245(0.19%) 256(0.20%) 0.74 0.74 206 (of 128965) 206 (of 128965) 0 high risk mrns high risk mrns 437.4 to 437.4(of 273853) 0.74 0.01
10ccs16:Liver/ibd ca model weights model weights 1641153 129284 752(0.05%) 788(0.05%) 51(0.04%) 51(0.04%) 0.75 0.75 61 (of 129284) 61 (of 129284) 11 high risk mrns high risk mrns 129.8 to 129.8(of 275056) 0.75 0.01
10ccs17:Pancreas can model weights model weights 1643059 129497 681(0.04%) 741(0.05%) 62(0.05%) 65(0.05%) 0.74 0.74 56 (of 129497) 56 (of 129497) 18 high risk mrns high risk mrns 119.0 to 119.0(of 275291) 0.74 0.00
10ccs22:Skin melanom model weights model weights 1629467 128563 2363(0.15%) 2491(0.15%) 182(0.14%) 185(0.14%) 0.73 0.72 160 (of 128563) 160 (of 128563) 0 high risk mrns high risk mrns 340.0 to 340.0(of 273202) 0.72 0.00
10ccs25:Uterus cancr model weights model weights 1637794 129025 1319(0.08%) 1464(0.09%) 127(0.10%) 133(0.10%) 0.81 0.81 107 (of 129025) 107 (of 129025) 0 high risk mrns high risk mrns 227.6 to 227.6(of 274494) 0.81 0.00
10ccs26:Cervix cancr model weights model weights 1631286 128354 4360(0.27%) 4843(0.30%) 374(0.29%) 411(0.32%) 0.85 0.85 300 (of 128354) 300 (of 128354) 0 high risk mrns high risk mrns 638.0 to 638.0(of 272972) 0.85 0.03
10ccs27:Ovary cancer model weights model weights 1639823 129059 863(0.05%) 918(0.06%) 66(0.05%) 72(0.06%) 0.77 0.78 54 (of 129059) 54 (of 129059) 0 high risk mrns high risk mrns 115.0 to 115.0(of 274832) 0.78 0.00
10ccs28:Fem genit ca model weights model weights 1641743 129399 715(0.04%) 725(0.04%) 50(0.04%) 48(0.04%) 0.78 0.78 55 (of 129399) 55 (of 129399) 0 high risk mrns high risk mrns 116.9 to 116.9(of 275093) 0.78 0.01
10ccs29:Prostate can model weights model weights 1617311 127850 3912(0.24%) 4435(0.27%) 308(0.24%) 342(0.27%) 0.94 0.94 278 (of 127850) 278 (of 127850) 0 high risk mrns high risk mrns 589.9 to 589.9(of 271288) 0.94 0.03
10ccs30:Testis cancr model weights model weights 1643341 129482 174(0.01%) 193(0.01%) 14(0.01%) 14(0.01%) 0.86 0.86 14 (of 129482) 14 (of 129482) 0 high risk mrns high risk mrns 29.8 to 29.8(of 275367) 0.86 0.00
10ccs31:Mal genit ca model weights model weights 1644472 129373 65(0.00%) 76(0.00%) 5(0.00%) 5(0.00%) 0.76 0.76 6 (of 129373) 6 (of 129373) 0 high risk mrns high risk mrns 12.8 to 12.8(of 275548) 0.76 0.00
10ccs14:Colon cancer model weights model weights 1632676 129070 2130(0.13%) 2431(0.15%) 165(0.13%) 192(0.15%) 0.77 0.77 148 (of 129070) 148 (of 129070) 0 high risk mrns high risk mrns 313.8 to 313.8(of 273653) 0.77 0.00
10ccs32:Bladder cncr model weights model weights 1637255 128868 1358(0.08%) 1469(0.09%) 112(0.09%) 114(0.09%) 0.83 0.82 109 (of 128868) 109 (of 128868) 0 high risk mrns high risk mrns 232.1 to 232.1(of 274398) 0.82 0.01
10ccs33:Kidny/rnl ca model weights model weights 1636525 129058 1175(0.07%) 1233(0.08%) 95(0.07%) 95(0.07%) 0.74 0.74 91 (of 129058) 91 (of 129058) 0 high risk mrns high risk mrns 193.5 to 193.5(of 274369) 0.74 0.00
10ccs35:Brain/ns can model weights model weights 1635601 129154 969(0.06%) 1127(0.07%) 78(0.06%) 89(0.07%) 0.65 0.65 75 (of 129154) 75 (of 129154) 0 high risk mrns high risk mrns 159.3 to 159.3(of 274312) 0.65 0.00
10ccs36:Thyroid cncr model weights model weights 1632392 129008 1721(0.11%) 1914(0.12%) 140(0.11%) 153(0.12%) 0.70 0.70 121 (of 129008) 121 (of 129008) 0 high risk mrns high risk mrns 256.6 to 256.6(of 273616) 0.70 0.00
10ccs40:Mult myeloma model weights model weights 1640535 129358 644(0.04%) 737(0.04%) 57(0.04%) 60(0.05%) 0.79 0.79 38 (of 129358) 38 (of 129358) 2 high risk mrns high risk mrns 80.8 to 80.8(of 274939) 0.79 0.00
10ccs44:Neoplsm unsp model weights model weights 1554965 122825 22878(1.47%) 24893(1.60%) 1683(1.37%) 1788(1.46%) 0.68 0.68 1635 (of 122825) 1635 (of 122825) 1 high risk mrns high risk mrns 3462.2 to 3462.2(of 260089) 0.68 0.04
10ccs56:Cystic fibro model weights model weights 1644049 129723 67(0.00%) 110(0.01%) 7(0.01%) 10(0.01%) 0.71 0.71 3 (of 129723) 3 (of 129723) 0 high risk mrns high risk mrns 6.4 to 6.4(of 275489) 0.71 0.00
10ccs59:Anemia model weights model weights 1478421 117282 34922(2.36%) 39372(2.66%) 2985(2.55%) 3357(2.86%) 0.68 0.67 2392 (of 117282) 2392 (of 117282) 2 high risk mrns high risk mrns 5051.7 to 5051.7(of 247692) 0.67 0.06
10ccs79:Parkinson-s model weights model weights 1634353 128676 1795(0.11%) 1975(0.12%) 158(0.12%) 168(0.13%) 0.82 0.83 127 (of 128676) 127 (of 128676) 11 high risk mrns high risk mrns 270.4 to 270.4(of 273994) 0.83 0.01
10ccs80:MS model weights model weights 1631900 128890 891(0.05%) 1022(0.06%) 85(0.07%) 92(0.07%) 0.65 0.65 65 (of 128890) 65 (of 128890) 1 high risk mrns high risk mrns 138.0 to 138.0(of 273595) 0.65 0.02
10ccs24:Breast cancr model weights model weights 1566584 124260 8772(0.56%) 9692(0.62%) 719(0.58%) 763(0.61%) 0.82 0.83 675 (of 124260) 675 (of 124260) 0 high risk mrns high risk mrns 1428.1 to 1428.1(of 262898) 0.83 0.03
10ccs83:Epilepsy/cnv model weights model weights 1596655 126297 5170(0.32%) 5477(0.34%) 460(0.36%) 481(0.38%) 0.67 0.67 375 (of 126297) 375 (of 126297) 0 high risk mrns high risk mrns 797.0 to 797.0(of 268412) 0.67 0.01
10ccs88:Glaucoma model weights model weights 1616479 126981 9691(0.60%) 10432(0.65%) 733(0.58%) 793(0.62%) 0.68 0.68 677 (of 126981) 677 (of 126981) 0 high risk mrns high risk mrns 1440.6 to 1440.6(of 270206) 0.68 0.01
10ccs89:Blindness model weights model weights 1588156 124505 21177(1.33%) 22471(1.41%) 2060(1.65%) 2157(1.73%) 0.67 0.66 1421 (of 124505) 1421 (of 124505) 0 high risk mrns high risk mrns 3015.9 to 3015.9(of 264248) 0.66 0.04
10ccs158:Chr ren fail model weights model weights 1598995 126496 10950(0.68%) 11998(0.75%) 965(0.76%) 1044(0.83%) 0.83 0.83 748 (of 126496) 748 (of 126496) 0 high risk mrns high risk mrns 1585.6 to 1585.6(of 268151) 0.83 0.05
10ccs157:Ac renl fail model weights model weights 1624603 127891 7767(0.48%) 8183(0.50%) 688(0.54%) 709(0.55%) 0.86 0.86 522 (of 127891) 522 (of 127891) 0 high risk mrns high risk mrns 1110.6 to 1110.6(of 272109) 0.86 0.04
10ccs653: Alzheimers and Dementia model weights model weights 1613092 127351 8174(0.51%) 8855(0.55%) 714(0.56%) 758(0.60%) 0.83 0.83 577 (of 127351) 577 (of 127351) 0 high risk mrns high risk mrns 1225.7 to 1225.7(of 270526) 0.83 0.05
10ccs96:Hrt valve dx model weights model weights 1461375 117733 34244(2.34%) 35235(2.41%) 2902(2.46%) 2925(2.48%) 0.73 0.73 2507 (of 117733) 2507 (of 117733) 1 high risk mrns high risk mrns 5266.4 to 5266.4(of 247317) 0.73 0.06
10ccs99:Htn complicn model weights model weights 1592414 125969 14713(0.92%) 15109(0.95%) 1096(0.87%) 1136(0.90%) 0.84 0.84 980 (of 125969) 980 (of 125969) 0 high risk mrns high risk mrns 2077.9 to 2077.9(of 267089) 0.84 0.06
10ccs101:Coron athero model weights model weights 1467389 117946 27215(1.85%) 29216(1.99%) 2316(1.96%) 2453(2.08%) 0.82 0.81 2003 (of 117946) 2003 (of 117946) 9 high risk mrns high risk mrns 4221.9 to 4221.9(of 248608) 0.81 0.07
10ccs103:Pulm hart dx model weights model weights 1606256 127158 7439(0.46%) 8906(0.55%) 428(0.34%) 443(0.35%) 0.77 0.77 567 (of 127158) 567 (of 127158) 0 high risk mrns high risk mrns 1200.9 to 1200.9(of 269318) 0.77 0.01
10ccs100:Acute MI model weights model weights 1616118 127670 4350(0.27%) 5201(0.32%) 492(0.39%) 534(0.42%) 0.85 0.84 301 (of 127670) 301 (of 127670) 0 high risk mrns high risk mrns 640.0 to 640.0(of 271469) 0.84 0.03
10ccs107:Cardia arrst model weights model weights 1642723 129304 777(0.05%) 875(0.05%) 74(0.06%) 83(0.06%) 0.78 0.76 58 (of 129304) 58 (of 129304) 15 high risk mrns high risk mrns 123.5 to 123.5(of 275269) 0.76 0.00
10ccs108:chf;nonhp model weights model weights 1595524 126305 10738(0.67%) 11254(0.71%) 930(0.74%) 962(0.76%) 0.88 0.88 774 (of 126305) 774 (of 126305) 0 high risk mrns high risk mrns 1643.5 to 1643.5(of 268199) 0.88 0.06
10ccs109:Acute CVD model weights model weights 1613529 127279 8624(0.53%) 8561(0.53%) 746(0.59%) 728(0.57%) 0.78 0.78 654 (of 127279) 654 (of 127279) 0 high risk mrns high risk mrns 1389.5 to 1389.5(of 270413) 0.78 0.02